Research
I am chairing the Critical Care Research Group with members based at the University of Liverpool and at the Royal Liverpool Intensive Care Unit. This group participates and leads in a wide range of cross-specialty research activities within infection, cardiovascular dysfunction and long-term outcomes of critical illness. Our portfolio includes early and late phase clinical trials, bench-to-bedside projects, systematic reviews, observational studies and advanced data analysis.
I am a member of the Liverpool Centre for Cardiovascular Science, where I bring in my experience as intensivist and cardiac anaesthetist to study risk factors, diagnosis and management of cardiac dysfunction and, more specifically, arrhythmias in critically ill patients. Spanning the gap between clinical and experimental work, I use different approaches to define the risk profiles for arrhythmias in critically ill patients: 1. We analyse large databases to identify clinical phenotypes and risk factors for new onset arrhythmias (Collaboration with Liverpool John Moores University). 2. I am Chief Investigator for a large observational studies on perioperative cardiovascular dysfunction. 3. In collaboration with basic researchers at the University I investigate the relationship between novel and established biomarkers and occurrence of arrhythmias, coagulopathy and cardiovascular dysfunction. 4. As part of a clinical research project with commercial partners and data scientists we explore novel monitoring techniques and Machine Learning to diagnose arrhythmias as early as possible, ideally before they become clinically relevant.
I am interested in identifying the best possible therapies for arrhythmias not only in acute illness, but also during a patient's recovery period. Cardiovascular dysfunction together with muscle wasting and mental health impact on functional status and quality of life. Therefore, our group's research stream on long-term outcomes of critical illness aims to describe and prevent psychological sequelae and functional impairment after life-threatening infection.
Research grants
From evidence to guidance on patient recruitment to clinical research in intensive care units.
ECONOMIC AND SOCIAL RESEARCH COUNCIL
September 2016 - May 2020
A prospective study of the aPTT waveform and lipoprotein-complexed C reactive protein assays in the early diagnosis and prognosis of sepsis
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
July 2011 - December 2012
The Role of Circulating Histones in the Cardiac Dysfunction of Sepsis.
BRITISH HEART FOUNDATION (UK)
September 2014 - August 2016
Bridging and accelerating the translation of novel scientific findings for health and wealth gain
MEDICAL RESEARCH COUNCIL
March 2014 - August 2015
Research collaborations
Prof. Bridget Young
Perspectives (PERSPectives on Enhancing Consent and recruiTment in IntensiVe carE Studies)
The PERSPECTIVES project aims to explore the views of multiple stakeholders on recruitment and consent methods in research studies performed in Critical Care.