Publications
2024
Stratified analyses refine association between TLR7 rare variants and severe COVID-19.
Boos, J., van der Made, C. I., Ramakrishnan, G., Coughlan, E., Asselta, R., Löscher, B. -S., . . . Ludwig, K. U. (2024). Stratified analyses refine association between TLR7 rare variants and severe COVID-19.. HGG advances, 5(4), 100323. doi:10.1016/j.xhgg.2024.100323
Statistical analysis plan for the biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2) study: An international randomised controlled multicentre trial.
von Groote, T., Danzer, M. F., Meersch, M., Zarbock, A., Gerß, J., & BigpAK-2 study group. (2024). Statistical analysis plan for the biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2) study: An international randomised controlled multicentre trial.. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 26(2), 80-86. doi:10.1016/j.ccrj.2024.03.001
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease.
Liew, F., Efstathiou, C., Fontanella, S., Richardson, M., Saunders, R., Swieboda, D., . . . ISARIC investigators. (2024). Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease.. Nature immunology, 25(4), 607-621. doi:10.1038/s41590-024-01778-0
Correction: Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL).
Pickkers, P., Angus, D. C., Bass, K., Bellomo, R., van den Berg, E., Bernholz, J., . . . REVIVAL investigators. (2024). Correction: Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL).. Intensive care medicine, 50(4), 614-615. doi:10.1007/s00134-024-07357-z
The association of premorbid conditions with 6-month mortality in acutely admitted ICU patients over 80 years.
de Lange, D. W., Soliman, I. W., Leaver, S., Boumendil, A., Haas, L. E. M., Watson, X., . . . VIP2 study group. (2024). The association of premorbid conditions with 6-month mortality in acutely admitted ICU patients over 80 years.. Annals of intensive care, 14(1), 46. doi:10.1186/s13613-024-01246-w
An International Survey of the Management of Atrial Fibrillation in Critically Unwell Patients.
Johnston, B. W., Udy, A. A., McAuley, D. F., Mogk, M., Welters, I. D., & Sibley, S. (2024). An International Survey of the Management of Atrial Fibrillation in Critically Unwell Patients.. Critical care explorations, 6(4), e1069. doi:10.1097/cce.0000000000001069
Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis.
Vaara, S. T., Serpa Neto, A., Bellomo, R., Adhikari, N. K. J., Dreyfuss, D., Gallagher, M., . . . STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Investigators . (2024). Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis.. Critical care explorations, 6(2), e1053. doi:10.1097/cce.0000000000001053
Guidance to inform research recruitment processes for studies involving critically ill patients
Woolfall, K., Paddock, K., Watkins, M., Kearney, A., Neville, K., Frith, L., . . . Young, B. (2023). Guidance to inform research recruitment processes for studies involving critically ill patients. JOURNAL OF THE INTENSIVE CARE SOCIETY. doi:10.1177/17511437231197293
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
RECOVERY Collaborative Group., Horby, P. W., Peto, L., Staplin, N., Campbell, M., Pessoa-Amorim, G., . . . Landray, M. J. (2024). Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.. Nature communications, 15(1), 924. doi:10.1038/s41467-023-43644-x
Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial.
RECOVERY Collaborative Group. (2024). Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial.. The Lancet. Child & adolescent health, S2352-4642(23)00316-4. doi:10.1016/s2352-4642(23)00316-4
Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)
Pickkers, P., Angus, D. C., Bass, K., Bellomo, R., van den Berg, E., Bernholz, J., . . . Hite, D. (2024). Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL). Intensive Care Medicine. doi:10.1007/s00134-023-07271-w
2023
Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19.
Sidhu, J. K., Siggins, M. K., Liew, F., Russell, C. D., Uruchurtu, A. S. S., Davis, C., . . . ISARIC4C investigators. (2023). Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19.. The Journal of infectious diseases, 230(1), e17-e29. doi:10.1093/infdis/jiad590
Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19.
Sidhu, J. K., Siggins, M. K., Liew, F., Russell, C. D., Uruchurtu, A. S. S., Davis, C., . . . ISARIC4C investigators. (2023). Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19.. The Journal of infectious diseases, jiad590. doi:10.1093/infdis/jiad590
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2023). Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 14(1), 8487. doi:10.1038/s41467-023-42320-4
Landiolol and Organ Failure in Patients With Septic Shock: The STRESS-L Randomized Clinical Trial.
Whitehouse, T., Hossain, A., Perkins, G. D., Gordon, A. C., Bion, J., Young, D., . . . STRESS-L Collaborators. (2023). Landiolol and Organ Failure in Patients With Septic Shock: The STRESS-L Randomized Clinical Trial.. JAMA, 330(17), 1641-1652. doi:10.1001/jama.2023.20134
Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial.
Wald, R., Gaudry, S., da Costa, B. R., Adhikari, N. K. J., Bellomo, R., Du, B., . . . STARRT-AKI Investigators. (2023). Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial.. Intensive care medicine, 49(11), 1305-1316. doi:10.1007/s00134-023-07211-8
Is your study acronym someone else's intellectual property?
Waite, A. A., Rogers, H., Winskill, S., & Welters, I. D. (2023). Is your study acronym someone else's intellectual property?. Journal of the Intensive Care Society, 24(3 Suppl), 61. doi:10.1177/17511437221121713
Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
RECOVERY Collaborative Group. (2023). Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.. The lancet. Diabetes & endocrinology, S2213-8587(23)00253-X. doi:10.1016/s2213-8587(23)00253-x
PIM-COVID study: protocol for a multicentre, longitudinal study measuring the psychological impact of surviving an intensive care admission due to COVID-19 on patients in the UK
Waite, A. A. C., Johnston, B. W., Boyle, A. J., Cherry, M. G., Fisher, P., Brown, S. L., . . . Welters, I. D. (2023). PIM-COVID study: protocol for a multicentre, longitudinal study measuring the psychological impact of surviving an intensive care admission due to COVID-19 on patients in the UK. BMJ OPEN, 13(9). doi:10.1136/bmjopen-2023-071730
Metabolomic analysis of exhaled breath can rule out ventilator-associated pneumonia (VAP) in critically ill patients
Ahmed, W., White, I., Van Oort, P., Rattray, N., Docherty, C., Bannard-Smith, J., . . . Fowler, S. (2023). Metabolomic analysis of exhaled breath can rule out ventilator-associated pneumonia (VAP) in critically ill patients. In Molecular pathology and functional genomics (pp. PA2963). European Respiratory Society. doi:10.1183/13993003.congress-2023.pa2963
Metabolomics of blood plasma from critically ill patients with suspected ventilator-associated pneumonia
Ahmed, W., Burke, A., Gotts, N., Van Oort, P., Bannard-Smith, J., Morton, B., . . . Fowler, S. (2023). Metabolomics of blood plasma from critically ill patients with suspected ventilator-associated pneumonia. In Molecular pathology and functional genomics (pp. PA2962). European Respiratory Society. doi:10.1183/13993003.congress-2023.pa2962
Study protocol: A systematic review and meta-analysis regarding the influence of coagulopathy and immune activation on new onset atrial fibrillation in patients with sepsis.
Downes, M., Welters, I. D., & Johnston, B. W. (2023). Study protocol: A systematic review and meta-analysis regarding the influence of coagulopathy and immune activation on new onset atrial fibrillation in patients with sepsis.. PloS one, 18(9), e0290963. doi:10.1371/journal.pone.0290963
A second update on mapping the human genetic architecture of COVID-19.
COVID-19 Host Genetics Initiative. (2023). A second update on mapping the human genetic architecture of COVID-19.. Nature, 621(7977), E7-E26. doi:10.1038/s41586-023-06355-3
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (vol 617, pg 764, 2023)
Pairo-Castineira, E., Rawlik, K., Bretherick, A. D., Qi, T., Wu, Y., Nassiri, I., . . . Baillie, J. K. (2023). GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (vol 617, pg 764, 2023). NATURE. doi:10.1038/s41586-023-06383-z
Who to escalate during a pandemic? A retrospective observational study about decision-making during the COVID-19 pandemic in the UK.
Beresford, S., Tandon, A., Farina, S., Johnston, B., Crews, M., & Welters, I. D. (2023). Who to escalate during a pandemic? A retrospective observational study about decision-making during the COVID-19 pandemic in the UK.. Emergency medicine journal : EMJ, emermed-2022-212505. doi:10.1136/emermed-2022-212505
Analysis of exhaled breath to identify critically ill patients with ventilator-associated pneumonia
Felton, T. W., Ahmed, W., White, I. R., van Oort, P., Rattray, N. J. W., Docherty, C., . . . Fowler, S. J. (2023). Analysis of exhaled breath to identify critically ill patients with ventilator-associated pneumonia. ANAESTHESIA, 78(6), 712-721. doi:10.1111/anae.15999
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
Pairo-Castineira, E., Rawlik, K., Bretherick, A. D., Qi, T., Wu, Y., Nassiri, I., . . . Baillie, J. K. (2023). GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. NATURE, 617(7962), 764-+. doi:10.1038/s41586-023-06034-3
Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cells (REALIST-COVID Trial): A Multicentre, Randomised, Controlled Trial.
Gorman, E. A., Rynne, J., Gardiner, H. J., Rostron, A. J., Bannard-Smith, J., Bentley, A. M., . . . O'Kane, C. M. (2023). Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cells (REALIST-COVID Trial): A Multicentre, Randomised, Controlled Trial.. American journal of respiratory and critical care medicine. doi:10.1164/rccm.202302-0297oc
Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial
Horby, P. W., Emberson, J. R., Basnyat, B., Campbell, M., Peto, L., Pessoa-Amorim, G., . . . Landray, M. J. (2023). Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial. LANCET, 401(10387), 1499-1507. doi:10.1016/S0140-6736(23)00510-X
Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study.
Pham, T., Heunks, L., Bellani, G., Madotto, F., Aragao, I., Beduneau, G., . . . WEAN SAFE Investigators. (2023). Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study.. The Lancet. Respiratory medicine, 11(5), 465-476. doi:10.1016/s2213-2600(22)00449-0
Development of Core Outcome Sets for trials on the management of Atrial fiBrillAtion in Critically Unwell patientS (COS-ABACUS): a protocol
Johnston, B., Hill, R. A., Blackwood, B., Lip, G. Y. H., & Welters, I. D. (2023). Development of Core Outcome Sets for trials on the management of Atrial fiBrillAtion in Critically Unwell patientS (COS-ABACUS): a protocol. BMJ open, 13(4), e067257. doi:10.1136/bmjopen-2022-067257
The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.
Goldswain, H., Dong, X., Penrice-Randal, R., Alruwaili, M., Shawli, G. T., Prince, T., . . . Hiscox, J. A. (2023). The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.. Genome biology, 24(1), 47. doi:10.1186/s13059-023-02881-5
Correction: Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial.
Bagshaw, S. M., Neto, A. S., Smith, O., Weir, M., Qiu, H., Du, B., . . . STARRT-AKI Investigators. (2023). Correction: Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial.. Intensive care medicine, 49(3), 381-383. doi:10.1007/s00134-023-06976-2
SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination
Liew, F., Talwar, S., Cross, A., Willett, B. J., Scott, S., Logan, N., . . . Openshaw, P. J. M. (2023). SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. EBIOMEDICINE, 87. doi:10.1016/j.ebiom.2022.104402
Sepsis-induced coagulopathy is associated with new episodes of atrial fibrillation in patients admitted to critical care in sinus rhythm
Ortega-Martorell, S., Olier, I., Johnston, B. W., & Welters, I. D. (2023). Sepsis-induced coagulopathy is associated with new episodes of atrial fibrillation in patients admitted to critical care in sinus rhythm. FRONTIERS IN MEDICINE, 10. doi:10.3389/fmed.2023.1230854
2022
Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study
Amado-Rodríguez, L., Rodríguez-Garcia, R., Bellani, G., Pham, T., Fan, E., Madotto, F., . . . Schomer, A. (2022). Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study. Journal of Intensive Care, 10(1). doi:10.1186/s40560-022-00648-x
Learning from stakeholders to inform good practice guidance on consent to research in intensive care units: a mixed-methods study.
Paddock, K., Woolfall, K., Kearney, A., Pattison, N., Frith, L., Gamble, C., . . . Young, B. (2022). Learning from stakeholders to inform good practice guidance on consent to research in intensive care units: a mixed-methods study.. BMJ open, 12(11), e066149. doi:10.1136/bmjopen-2022-066149
REPAIR OF ACUTE RESPIRATORY DISTRESS SYNDROME IN COVID-19 BY STROMAL CELLS (REALIST-COVID TRIAL): 1 YEAR FOLLOW UP FOR SAFETY AND PULMONARY DYSFUNCTION
Gardiner, H. J., Gorman, E. A., Rostron, A. J., Shankar-Hari, M., Bannard-Smith, J., Bentley, A. M., . . . O'Kane, C. M. (2022). REPAIR OF ACUTE RESPIRATORY DISTRESS SYNDROME IN COVID-19 BY STROMAL CELLS (REALIST-COVID TRIAL): 1 YEAR FOLLOW UP FOR SAFETY AND PULMONARY DYSFUNCTION. In THORAX Vol. 77 (pp. A30). doi:10.1136/thorax-2022-BTSabstracts.50
Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study
Vink, E., Davis, C., MacLean, A., Pascall, D., McDonald, S. E., Gunson, R., . . . Ho, A. (2022). Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. OPEN FORUM INFECTIOUS DISEASES, 9(11). doi:10.1093/ofid/ofac531
Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.
Siggins, M. K., Davies, K., Fellows, R., Thwaites, R. S., Baillie, J. K., Semple, M. G., . . . ISARIC4C Investigators. (2022). Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.. Immunology. doi:10.1111/imm.13585
Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number
Keeling, M. J., Dyson, L., Guyver-Fletcher, G., Holmes, A., Semple, M. G., Tildesley, M. J., & Hill, E. M. (2022). Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number. STATISTICAL METHODS IN MEDICAL RESEARCH, 31(9), 1716-1737. doi:10.1177/09622802211070257
Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis
Horby, P. W., Emberson, J. R., Mafham, M., Campbell, M., Peto, L., Pessoa-Amorim, G., . . . Landray, M. J. (2022). Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis. LANCET, 400(10349), 359-368. Retrieved from https://www.webofscience.com/
Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19
Norris, T., Razieh, C., Zaccardi, F., Yates, T., Islam, N., Gillies, C. L., . . . Khunti, K. (2022). Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19. HEART, 108(15), 1200-1208. doi:10.1136/heartjnl-2021-320047
In-Hospital Mortality of Sepsis Differs Depending on the Origin of Infection: An Investigation of Predisposing Factors.
Pieroni, M., Olier, I., Ortega-Martorell, S., Johnston, B. W., & Welters, I. D. (2022). In-Hospital Mortality of Sepsis Differs Depending on the Origin of Infection: An Investigation of Predisposing Factors.. Frontiers in medicine, 9, 915224. doi:10.3389/fmed.2022.915224
Whole-genome sequencing reveals host factors underlying critical COVID-19
Kousathanas, A., Pairo-Castineira, E., Rawlik, K., Stuckey, A., Odhams, C. A., Walker, S., . . . Baillie, J. K. (2022). Whole-genome sequencing reveals host factors underlying critical COVID-19. NATURE, 607(7917), 97-+. doi:10.1038/s41586-022-04576-6
PROcalcitonin and NEWS2 evaluation for Timely identification of sepsis and Optimal use of antibiotics in the emergency department (PRONTO protocol for a multicentre, open-label, randomised controlled trial
Euden, J., Thomas-Jones, E., Aston, S., Brookes-Howell, L., Carman, J., Carrol, E., . . . French, N. (2022). PROcalcitonin and NEWS2 evaluation for Timely identification of sepsis and Optimal use of antibiotics in the emergency department (PRONTO protocol for a multicentre, open-label, randomised controlled trial. BMJ OPEN, 12(6). doi:10.1136/bmjopen-2022-063424
Can Beta-D-Glucan testing as part of the diagnostic pathway for invasive fungal infection reduce anti-fungal treatment costs?
Hamilton, D. O., Lambe, T., Howard, A., Crossey, P., Hughes, J., Duarte, R., & Welters, I. D. (2022). Can Beta-D-Glucan testing as part of the diagnostic pathway for invasive fungal infection reduce anti-fungal treatment costs?. MEDICAL MYCOLOGY, 60(5). doi:10.1093/mmy/myac034
Development of a Risk Prediction Model for New Episodes of Atrial Fibrillation in Medical-Surgical Critically Ill Patients Using the AmsterdamUMCdb.
Ortega-Martorell, S., Pieroni, M., Johnston, B. W., Olier, I., & Welters, I. D. (2022). Development of a Risk Prediction Model for New Episodes of Atrial Fibrillation in Medical-Surgical Critically Ill Patients Using the AmsterdamUMCdb.. Frontiers in cardiovascular medicine, 9, 897709. doi:10.3389/fcvm.2022.897709
Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cell Administration (REALIST-COVID) Phase 2 Randomised Controlled Trial
Gorman, E., McAuley, D. F., Rostron, A. J., Shankar-Hari, M., Bannard-Smith, J., Bentley, A. M., . . . O'Kane, C. M. (2022). Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cell Administration (REALIST-COVID) Phase 2 Randomised Controlled Trial. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 205. Retrieved from https://www.webofscience.com/
Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study
Millar, J. E., Neyton, L., Seth, S., Dunning, J., Merson, L., Murthy, S., . . . Baillie, J. K. (2022). Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-08032-3
A Retrospective Observational Study of Anticoagulation Practices in Critically ill Patients with Atrial Fibrillation Admitted to the Intensive Care Unit
Johnston, B., Miller, N., Welters, I., Waite, A., Hampden-Martin, A., & Waugh, V. (2022). A Retrospective Observational Study of Anticoagulation Practices in Critically ill Patients with Atrial Fibrillation Admitted to the Intensive Care Unit. Journal of Intensive Care Medicine. doi:10.1177/08850666221092997
Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19 A Randomized Clinical Trial
Bradbury, C. A., Lawler, P. R., Stanworth, S. J., McVerry, B. J., McQuilten, Z., Higgins, A. M., . . . Gordon, A. C. (2022). Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19 A Randomized Clinical Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 327(13), 1247-1259. doi:10.1001/jama.2022.2910
Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study
Narhi, F., Moonesinghe, S. R., Shenkin, S. D., Drake, T. M., Mulholland, R. H., Donegan, C., . . . Docherty, A. B. (2022). Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. LANCET DIGITAL HEALTH, 4(4). Retrieved from https://www.webofscience.com/
Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis.
Maddali, M. V., Churpek, M., Pham, T., Rezoagli, E., Zhuo, H., Zhao, W., . . . LUNG SAFE Investigators and the ESICM Trials Group. (2022). Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis.. The Lancet. Respiratory medicine, 10(4), 367-377. doi:10.1016/s2213-2600(21)00461-6
Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Horby, P. W., Mafham, M., Peto, L., Campbell, M., Pessoa-Amorim, G., Spata, E., . . . Landray, M. J. (2022). Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. LANCET, 399(10325), 665-676. Retrieved from https://www.webofscience.com/
Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19 The RECOVERY-RS Randomized Clinical Trial
Perkins, G. D., Ji, C., Connolly, B. A., Couper, K., Lall, R., Baillie, J. K., . . . McAuley, D. F. (2022). Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19 The RECOVERY-RS Randomized Clinical Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 327(6), 546-558. doi:10.1001/jama.2022.0028
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (2022). SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. Cell, 185(3), 467-484.e15. doi:10.1016/j.cell.2021.12.046
Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies.
Pisani, L., Algera, A. G., Neto, A. S., Azevedo, L., Pham, T., Paulus, F., . . . PRoVENT-iMiC study investigators. (2022). Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies.. The Lancet. Global health, 10(2), e227-e235. doi:10.1016/s2214-109x(21)00485-x
Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Horby, P. W., Pessoa-Amorim, G., Staplin, N., Emberson, J. R., Campbell, M., Spata, E., . . . Landray, M. J. (2022). Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. LANCET, 399(10320), 143-151. doi:10.1016/S0140-6736(21)01825-0
Multicentre evaluation of two multiplex PCR platforms for the rapid microbiological investigation of nosocomial pneumonia in UK ICUs: the INHALE WP1 study.
Enne, V. I., Aydin, A., Baldan, R., Owen, D. R., Richardson, H., Ricciardi, F., . . . INHALE WP1 Study Group. (2022). Multicentre evaluation of two multiplex PCR platforms for the rapid microbiological investigation of nosocomial pneumonia in UK ICUs: the INHALE WP1 study.. Thorax, 77(12), 1220-1228. doi:10.1136/thoraxjnl-2021-216990
Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol
Knight, S. R., Gupta, R. K., Ho, A., Pius, R., Buchan, I., Carson, G., . . . Harrison, E. M. (2022). Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. THORAX, 77(6), 606-615. doi:10.1136/thoraxjnl-2021-217629
2021
Mapping the human genetic architecture of COVID-19
Niemi, M. E. K., Karjalainen, J., Daly, M., Ganna, A., Mehtonen, J., Cordioli, M., . . . Dopazo, X. (2021). Mapping the human genetic architecture of COVID-19. NATURE, 600(7889), 472-+. doi:10.1038/s41586-021-03767-x
Management of new onset atrial fibrillation in critically unwell adult patients: a systematic review and narrative synthesis
Johnston, B. W., Chean, C. S., Duarte, R., Hill, R., Blackwood, B., McAuley, D. F., & Welters, I. D. (2021). Management of new onset atrial fibrillation in critically unwell adult patients: a systematic review and narrative synthesis. British Journal of Anaesthesia. doi:10.1016/j.bja.2021.11.016
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.
Fallerini, C., Picchiotti, N., Baldassarri, M., Zguro, K., Daga, S., Fava, F., . . . Furini, S. (2021). Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.. Human genetics, 141(1), 147-173. doi:10.1007/s00439-021-02397-7
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells
de, S. T. I., Liu, G., Lindsey, B. B., Dong, D., Moore, S. C., Hsu, N. S., . . . Dong, T. (2021). The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. ISCIENCE, 24(11). doi:10.1016/j.isci.2021.103353
Standard- versus intermediate-dose enoxaparin for anti-factor Xa guided thromboprophylaxis in critically ill patients with COVID-19
Hamilton, D. O., Main-Ian, A., Tebbutt, J., Thrasher, M., Waite, A., & Welters, I. (2021). Standard- versus intermediate-dose enoxaparin for anti-factor Xa guided thromboprophylaxis in critically ill patients with COVID-19. THROMBOSIS JOURNAL, 19(1). doi:10.1186/s12959-021-00337-z
Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19 A Randomized Clinical Trial
Estcourt, L. J., Turgeon, A. F., McQuilten, Z. K., McVerry, B. J., Al-Beidh, F., Annane, D., . . . Shankar-Hari, M. (2021). Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19 A Randomized Clinical Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 326(17), 1690-1702. doi:10.1001/jama.2021.18178
A prenylated dsRNA sensor protects against severe COVID-19
Wickenhagen, A., Sugrue, E., Lytras, S., Kuchi, S., Noerenberg, M., Turnbull, M. L., . . . Wilson, S. J. (2021). A prenylated dsRNA sensor protects against severe COVID-19. SCIENCE, 374(6567). doi:10.1126/science.abj3624
Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study
Hurst, E. A., Mellanby, R. J., Handel, I., Griffith, D. M., Rossi, A. G., Walsh, T. S., . . . Russell, C. D. (2021). Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study. BMJ OPEN, 11(10). doi:10.1136/bmjopen-2021-055435
Management and outcomes in critically ill nonagenarian versus octogenarian patients
Bruno, R. R., Wernly, B., Kelm, M., Boumendil, A., Morandi, A., Andersen, F. H., . . . Jung, C. (2021). Management and outcomes in critically ill nonagenarian versus octogenarian patients. BMC GERIATRICS, 21(1). doi:10.1186/s12877-021-02476-4
Strategies to enhance recruitment and consent to intensive care studies: a qualitative study with researchers and patient-public involvement contributors
Paddock, K., Woolfall, K., Frith, L., Watkins, M., Gamble, C., Welters, I., & Young, B. (2021). Strategies to enhance recruitment and consent to intensive care studies: a qualitative study with researchers and patient-public involvement contributors. BMJ OPEN, 11(9). doi:10.1136/bmjopen-2020-048193
Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure The REST Randomized Clinical Trial
McNamee, J. J., Gillies, M. A., Barrett, N. A., Perkins, G. D., Tunnicliffe, W., Young, D., . . . McAuley, D. F. (2021). Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure The REST Randomized Clinical Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 326(11), 1013-1023. doi:10.1001/jama.2021.13374
Frailty is associated with long-term outcome in patients with sepsis who are over 80 years old: results from an observational study in 241 European ICUs
Haas, L. E. M., Boumendil, A., Flaatten, H., Guidet, B., Ibarz, M., Jung, C., . . . de Lange, D. W. (2021). Frailty is associated with long-term outcome in patients with sepsis who are over 80 years old: results from an observational study in 241 European ICUs. AGE AND AGEING, 50(5), 1719-1727. doi:10.1093/ageing/afab036
Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19
Goligher, E. C., Bradbury, C. A., McVerry, B. J., Lawler, P. R., Berger, J. S., Gong, M. N., . . . Zhong, Y. (2021). Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. NEW ENGLAND JOURNAL OF MEDICINE, 385(9), 777-789. doi:10.1056/NEJMoa2103417
Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19
Lawler, P. R., Golighe, E. C., Berge, J. S., Neal, M. D., McVerry, B. J., Nicolau, J. C., . . . Zampieri, F. G. (2021). Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. NEW ENGLAND JOURNAL OF MEDICINE, 385(9), 790-802. doi:10.1056/NEJMoa2105911
Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study
Russell, C. D., Fairfield, C. J., Drake, T. M., Turtle, L., Seaton, R. A., Wootton, D. G., . . . Ho, A. (2021). Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. LANCET MICROBE, 2(8), E354-E365. doi:10.1016/S2666-5247(21)00090-2
Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial
Arabi, Y. M., Gordon, A. C., Derde, L. P. G., Nichol, A. D., Murthy, S., Al Beidh, F., . . . Webb, S. A. (2021). Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial. INTENSIVE CARE MEDICINE, 47(8), 867-886. doi:10.1007/s00134-021-06448-5
Pressure injury prediction models for critically-ill patients should consider both the case-mix and local factors.
Deschepper, M., Labeau, S. O., Waegeman, W., Blot, S. I., DecubICUs study Team., & European Society of Intensive Care Medicine (ESICM) Trials Group collaborators. (2021). Pressure injury prediction models for critically-ill patients should consider both the case-mix and local factors.. Intensive & critical care nursing, 65, 103033. doi:10.1016/j.iccn.2021.103033
Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study
Drake, T. M., Riad, A. M., Fairfield, C. J., Egan, C., Knight, S. R., Pius, R., . . . Semple, M. G. (2021). Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. LANCET, 398(10296), 223-237. Retrieved from https://www.webofscience.com/
Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK
Docherty, A., Mulholland, R., Lone, N. I., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . Semple, M. (2021). Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 773-785. doi:10.1016/S2213-2600(21)00175-2
Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.
Drake, T. M., Fairfield, C. J., Pius, R., Knight, S. R., Norman, L., Girvan, M., . . . ISARIC4C Investigators. (2021). Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.. The Lancet. Rheumatology, 3(7), e498-e506. doi:10.1016/s2665-9913(21)00104-1
Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort
Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., . . . Khunti, K. (2021). Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort. OBESITY, 29(7), 1223-1230. doi:10.1002/oby.23178
Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study
Fronczek, J., Polok, K., de Lange, D. W., Jung, C., Beil, M., Rhodes, A., . . . Szczeklik, W. (2021). Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study. CRITICAL CARE, 25(1). doi:10.1186/s13054-021-03632-3
Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK
Bloom, C. I., Drake, T. M., Docherty, A. B., Lipworth, B. J., Johnston, S. L., Nguyen-Van-Tam, J. S., . . . Openshaw, P. J. M. (2021). Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 699-711. doi:10.1016/S2213-2600(21)00013-8
Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England
Leclerc, Q. J., Fuller, N. M., Keogh, R. H., Diaz-Ordaz, K., Sekula, R., Semple, M. G., . . . Knight, G. M. (2021). Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England. BMC HEALTH SERVICES RESEARCH, 21(1). doi:10.1186/s12913-021-06509-x
Provision of critical care for the elderly in Europe: a retrospective comparison of national healthcare frameworks in intensive care units.
Wernly, B., Beil, M., Bruno, R. R., Binnebössel, S., Kelm, M., Sigal, S., . . . VIP2 study group. (2021). Provision of critical care for the elderly in Europe: a retrospective comparison of national healthcare frameworks in intensive care units.. BMJ open, 11(6), e046909. doi:10.1136/bmjopen-2020-046909
Going viral: misinformation in the time of COVID-19
Going viral: misinformation in the time of COVID-19 (2021). LANCET RHEUMATOLOGY, 3(6), E393. doi:10.1016/S2665-9913(21)00104-1
Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study
Pham, T., Pesenti, A., Bellani, G., Rubenfeld, G., Fan, E., Bugedo, G., . . . Laffey, J. G. (2021). Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study. EUROPEAN RESPIRATORY JOURNAL, 57(6). doi:10.1183/13993003.03317-2020
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
Horby, P. W., Landray, M. J., & Grp, R. E. C. O. V. E. R. Y. C. (2021). Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. LANCET, 397(10289), 2049-2059. doi:10.1016/S0140-6736(21)00897-7
Natural history, trajectory, and management of mechanically ventilated COVID-19 patients in the United Kingdom
Patel, B. V., Haar, S., Handslip, R., Auepanwiriyakul, C., Lee, T. M. -L., Patel, S., . . . Faisal, A. A. (2021). Natural history, trajectory, and management of mechanically ventilated COVID-19 patients in the United Kingdom. INTENSIVE CARE MEDICINE, 47(5), 549-565. doi:10.1007/s00134-021-06389-z
Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Horby, P. W., & Landray, M. J. (2021). Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. LANCET, 397(10285), 1637-1645. Retrieved from https://www.webofscience.com/
Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19
Gordon, A. C., Al-Beidh, F., Rowan, K. M., Nichol, A. D., Arabi, Y. M., Annane, D., . . . Derde, L. P. G. (2021). Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. NEW ENGLAND JOURNAL OF MEDICINE, 384(16), 1491-1502. doi:10.1056/NEJMoa2100433
Death in hospital following ICU discharge: insights from the LUNG SAFE study
Madotto, F., McNicholas, B., Rezoagli, E., Tai, P., Laffey, J. G., & Bellani, G. (2021). Death in hospital following ICU discharge: insights from the LUNG SAFE study. CRITICAL CARE, 25(1). doi:10.1186/s13054-021-03465-0
A Systematic Review of Anticoagulation Strategies for Patients With Atrial Fibrillation in Critical Care.
Nelson, A. J., Johnston, B. W., Waite, A. A. C., Lemma, G., & Welters, I. D. (2021). A Systematic Review of Anticoagulation Strategies for Patients With Atrial Fibrillation in Critical Care.. Thrombosis and Haemostasis. doi:10.1055/a-1477-3760
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study.
Labeau, S. O., Afonso, E., Benbenishty, J., Blackwood, B., Boulanger, C., Brett, S. J., . . . European Society of Intensive Care Medicine (ESICM) Trials Group Collaborators. (2021). Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study.. Intensive care medicine, 47(4), 503-520. doi:10.1007/s00134-020-06327-5
Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study
Gupta, R. K., Harrison, E. M., Ho, A., Docherty, A. B., Knight, S. R., van Smeden, M., . . . Noursadeghi, M. (2021). Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(4), 349-359. doi:10.1016/S2213-2600(20)30559-2
Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial
Shehabi, Y., Neto, A. S., Howe, B. D., Bellomo, R., Arabi, Y. M., Bailey, M., . . . Webb, S. A. (2021). Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial. INTENSIVE CARE MEDICINE, 47(4), 455-466. doi:10.1007/s00134-021-06356-8
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
Labeau, S. O., Afonso, E., Benbenishty, J., Blackwood, B., Boulanger, C., Brett, S. J., . . . Blot, S. I. (2021). Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study. INTENSIVE CARE MEDICINE, 47(2), 160-169. doi:10.1007/s00134-020-06234-9
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity
Thomson, E. C., Rosen, L. E., Shepherd, J. G., Spreafico, R., Filipe, A. D. S., Wojcechowskyj, J. A., . . . Snell, G. (2021). Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. CELL, 184(5), 1171-+. doi:10.1016/j.cell.2021.01.037
Genetic mechanisms of critical illness in COVID-19
Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A. D., Rawlik, K., Pasko, D., . . . Baillie, J. K. (2021). Genetic mechanisms of critical illness in COVID-19. NATURE, 591(7848), 92-+. doi:10.1038/s41586-020-03065-y
Retraction notice to “Normothermic versus hypothermic cardiopulmonary bypass: do changes in coagulation differ?” [ 62 (1996) 130-135]
Boldt, J., Knothe, C., Welters, I., Dapper, F. L., & Hempelmann, G. (2021). Retraction notice to “Normothermic versus hypothermic cardiopulmonary bypass: do changes in coagulation differ?” [ 62 (1996) 130-135]. The Annals of Thoracic Surgery, 111(3), e229. doi:10.1016/j.athoracsur.2021.01.004
Temporal changes in the epidemiology, management, and outcome from acute respiratory distress syndrome in European intensive care units: a comparison of two large cohorts.
Sakr, Y., François, B., Solé-Violan, J., Kotfis, K., Jaschinski, U., Estella, A., . . . SOAP and ICON Investigators. (2021). Temporal changes in the epidemiology, management, and outcome from acute respiratory distress syndrome in European intensive care units: a comparison of two large cohorts.. Critical care (London, England), 25(1), 87. doi:10.1186/s13054-020-03455-8
Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Horby, P. W., Roddick, A., Spata, E., Staplin, N., Emberson, J., Pessoa-Amorim, G., . . . Yates, H. (2021). Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. LANCET, 397(10274), 605-612. doi:10.1016/S0140-6736(21)00149-5
Point of care ultrasound in acutely breathless patients-A qualitative study of the enablers and challenges in a teaching hospital in Kenya
Kagima, J. W., Masheti, S. A., Mbaiyani, C. W., Munubi, A. Z., Ringwald, B., Meme, H. K., . . . Rylance, J. (n.d.). Point of care ultrasound in acutely breathless patients-A qualitative study of the enablers and challenges in a teaching hospital in Kenya. Journal of the Pan African Thoracic Society, 2, 130-139. doi:10.25259/jpats_24_2021
Reduced exposure to vasopressors through permissive hypotension to reduce mortality in critically ill peoble aged 65 and over; the 65 RCT
Mouncey, P. R., Richards-Belle, A., Thomas, K., Harrison, D. A., Sadique, M. Z., Grieve, R. D., . . . Rowan, K. M. (2021). Reduced exposure to vasopressors through permissive hypotension to reduce mortality in critically ill peoble aged 65 and over; the 65 RCT. HEALTH TECHNOLOGY ASSESSMENT, 25(14), I-+. doi:10.3310/hta25140
2020
Hypercoagulopathy in Severe COVID-19: Implications for Acute Care.
Waite, A. A. C., Hamilton, D. O., Pizzi, R., Ageno, W., & Welters, I. D. (2020). Hypercoagulopathy in Severe COVID-19: Implications for Acute Care.. Thrombosis and Haemostasis, 120(12), 1654-1667. doi:10.1055/s-0040-1721487
Natural history, trajectory, and management of mechanically ventilated COVID-19 patients in the United Kingdom
Letter by Hamilton et al Regarding Article, "Comparison of Venous Thromboembolism Risks Between COVID-19 Pneumonia and Community-Acquired Pneumonia Patients"
Hamilton, D. O., Waite, A. A. C., & Welters, I. D. (2020). Letter by Hamilton et al Regarding Article, "Comparison of Venous Thromboembolism Risks Between COVID-19 Pneumonia and Community-Acquired Pneumonia Patients". ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 40(11), E309-E310. doi:10.1161/ATVBAHA.120.315235
Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020
Thompson, C. P., Grayson, N. E., Paton, R. S., Bolton, J. S., Lourenco, J., Penman, B. S., . . . Simmonds, P. (2020). Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. EUROSURVEILLANCE, 25(42), 33-41. doi:10.2807/1560-7917.ES.2020.25.42.2000685
Anticoagulation strategies in critical care for the treatment of atrial fibrillation: a protocol for a systematic review and meta-analysis
Johnston, B., Nelson, A., Waite, A. C., Lemma, G., & Welters, I. (2020). Anticoagulation strategies in critical care for the treatment of atrial fibrillation: a protocol for a systematic review and meta-analysis. BMJ OPEN, 10(10). doi:10.1136/bmjopen-2020-037591
Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.
Drake, T. M., Docherty, A. B., Harrison, E. M., Quint, J. K., Adamali, H., Agnew, S., . . . ISARIC4C Investigators. (2020). Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.. Am J Respir Crit Care Med. doi:10.1164/rccm.202007-2794OC
Does the type of volume therapy influence endothelial-related coagulation in the critically ill? (Retraction of Vol 75, Pg 740, 1995)
Boldt, J., Heesen, M., Welters, I., Padberg, W., Martin, K., & Hempelmann, G. (2020). Does the type of volume therapy influence endothelial-related coagulation in the critically ill? (Retraction of Vol 75, Pg 740, 1995). BRITISH JOURNAL OF ANAESTHESIA, 125(3), 415. doi:10.1016/j.bja.2020.07.034
More research is required to understand factors influencing antibiotic prescribing in complex conditions like suspected ventilator-associated pneumonia
Hellyer, T. P., McAuley, D. F., Walsh, T. S., Anderson, N., Morris, A. C., Singh, S., . . . Simpson, A. J. (2020). More research is required to understand factors influencing antibiotic prescribing in complex conditions like suspected ventilator-associated pneumonia. ANNALS OF TRANSLATIONAL MEDICINE, 8(13). doi:10.21037/atm-20-3701
Early elevation in plasma high-sensitivity troponin T and morbidity after elective noncardiac surgery: prospective multicentre observational cohort study
Ackland, G. L., Abbott, T. E. F., Jones, T. F., Leuwer, M., & Pearse, R. M. (2020). Early elevation in plasma high-sensitivity troponin T and morbidity after elective noncardiac surgery: prospective multicentre observational cohort study. BRITISH JOURNAL OF ANAESTHESIA, 124(5), 535-543. doi:10.1016/j.bja.2020.02.003
The clinical relevance of oliguria in the critically ill patient: analysis of a large observational database
Vincent, J. -L., Ferguson, A., Pickkers, P., Jakob, S. M., Jaschinski, U., Almekhlafi, G. A., . . . Sakr, Y. (2020). The clinical relevance of oliguria in the critically ill patient: analysis of a large observational database. CRITICAL CARE, 24(1). doi:10.1186/s13054-020-02858-x
The whole blood phagocytosis assay: a clinically relevant test of neutrophil function and dysfunction in community-acquired pneumonia
Reine, J., Rylance, J., Ferreira, D. M., Pennington, S. H., Welters, I. D., Parker, R., & Morton, B. (2020). The whole blood phagocytosis assay: a clinically relevant test of neutrophil function and dysfunction in community-acquired pneumonia. BMC RESEARCH NOTES, 13(1). doi:10.1186/s13104-020-05034-0
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: insights from the LUNG SAFE study
Madotto, F., Rezoagli, E., Tai, P., Schmidt, M., McNicholas, B., Protti, A., . . . Laffey, J. G. (2020). Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: insights from the LUNG SAFE study. CRITICAL CARE, 24(1). doi:10.1186/s13054-020-2826-6
40th International Symposium on Intensive Care & Emergency Medicine : Brussels, Belgium. 24-27 March 2020.
40th International Symposium on Intensive Care & Emergency Medicine : Brussels, Belgium. 24-27 March 2020. (2020). In Critical care (London, England) Vol. 24 (pp. 87). doi:10.1186/s13054-020-2772-3
The whole blood phagocytosis assay: a clinically relevant test of neutrophil function and dysfunction in community-acquired pneumonia
Reiné, J., Rylance, J., Ferreira, D., Pennington, S., Welters, I. D., Parker, R., & Morton, B. (2020). The whole blood phagocytosis assay: a clinically relevant test of neutrophil function and dysfunction in community-acquired pneumonia. doi:10.21203/rs.2.24645/v2
Multiple organ dysfunction after trauma
Cole, E., Gillespie, S., Vulliamy, P., Brohi, K., Akkad, H., Apostolidou, K., . . . Welters, I. (2020). Multiple organ dysfunction after trauma. BRITISH JOURNAL OF SURGERY, 107(4), 402-412. doi:10.1002/bjs.11361
A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit.
Abrams, S., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2020). A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit.. Clinical medicine (London, England), 20(Suppl 2), s114-s115. doi:10.7861/clinmed.20-2-s114
The whole blood phagocytosis assay: a clinically relevant test of neutrophil function and dysfunction in community-acquired pneumonia
Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation
Hellyer, T. P., McAuley, D. F., Walsh, T. S., Anderson, N., Morris, A. C., Singh, S., . . . Simpson, A. J. (2020). Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation. LANCET RESPIRATORY MEDICINE, 8(2), 182-191. doi:10.1016/S2213-2600(19)30367-4
The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study
Guidet, B., de Lange, D. W., Boumendil, A., Leaver, S., Watson, X., Boulanger, C., . . . Flaatten, H. (2020). The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study. INTENSIVE CARE MEDICINE, 46(1), 57-69. doi:10.1007/s00134-019-05853-1
2019
The use of hand held ultrasound devices to measure muscle architecture – a comparison to standard ultrasound using healthy volunteers.
Turton, P., Hay, R., & Welters, I. D. M. (2019). The use of hand held ultrasound devices to measure muscle architecture – a comparison to standard ultrasound using healthy volunteers.. Poster session presented at the meeting of ICS State of the Art Meeting 2018. London.
A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies
Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2019). A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies. In BLOOD Vol. 134. Retrieved from https://www.webofscience.com/
A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies
Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2019). A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies. In BLOOD Vol. 134. doi:10.1182/blood-2019-128493
Protocol for a systematic review and network meta-analysis of the management of new onset atrial fibrillation in critically unwell adult patients
Johnston, B. W., Hill, R., Duarte, R., Chean, C. S., McAuley, D. F., Blackwood, B., . . . Welters, I. D. (2019). Protocol for a systematic review and network meta-analysis of the management of new onset atrial fibrillation in critically unwell adult patients. SYSTEMATIC REVIEWS, 8(1). doi:10.1186/s13643-019-1149-7
A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients
Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M., Lane, S., Welters, I. D., . . . Toh, C. -H. (2019). A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients. American journal of respiratory and critical care medicine, 200(07), 869-880. doi:10.1164/rccm.201811-2111oc
Impact of Early Acute Kidney Injury on Management and Outcome in Patients With Acute Respiratory Distress Syndrome: A Secondary Analysis of a Multicenter Observational Study
McNicholas, B. A., Rezoagli, E., Pham, T., Madotto, F., Guiard, E., Fanelli, V., . . . Laffey, J. G. (2019). Impact of Early Acute Kidney Injury on Management and Outcome in Patients With Acute Respiratory Distress Syndrome: A Secondary Analysis of a Multicenter Observational Study. CRITICAL CARE MEDICINE, 47(9), 1216-1225. doi:10.1097/CCM.0000000000003832
Assessment of peripheral muscle thickness and architecture in healthy volunteers using hand-held ultrasound devices; a comparison study with standard ultrasound
Turton, P., Hay, R., & Welters, I. (2019). Assessment of peripheral muscle thickness and architecture in healthy volunteers using hand-held ultrasound devices; a comparison study with standard ultrasound. BMC MEDICAL IMAGING, 19(1). doi:10.1186/s12880-019-0373-x
Early Sedation with Dexmedetomidine in Critically Ill Patients
Shehabi, Y., Howe, B. D., Bellomo, R., Arabi, Y. M., Bailey, M., Bass, F. E., . . . Webb, S. A. (2019). Early Sedation with Dexmedetomidine in Critically Ill Patients. NEW ENGLAND JOURNAL OF MEDICINE, 380(26), 2506-2517. doi:10.1056/NEJMoa1904710
Heart rate variability: Measurement and emerging use in critical care medicine
Johnston, B., Barrett-Jolley, R., Krige, A., & Welters, I. D. M. (2019). Heart rate variability: Measurement and emerging use in critical care medicine. Journal of the Intensive Care Society. doi:10.1177/1751143719853744
Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial
Peden, C. J., Stephens, T., Martin, G., Kahan, B. C., Thomson, A., Rivett, K., . . . Pearse, R. M. (2019). Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial. LANCET, 393(10187), 2213-2221. doi:10.1016/S0140-6736(18)32521-2
Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy The SCARLET Randomized Clinical Trial
Vincent, J. -L., Francois, B., Zabolotskikh, I., Daga, M. K., Lascarrou, J. -B., Kirov, M. Y., . . . Kayanoki, T. (2019). Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy The SCARLET Randomized Clinical Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 321(20), 1993-2002. doi:10.1001/jama.2019.5358
The influence of acute preoperative plasmapheresis on coagulation tests, fibrinolysis, blood loss and transfusion requirements in cardiac surgery (Retraction of Vol 11, Pg 557, 1997)
Menges, T., Welters, I., Wagner, R. -M., Boldt, J., Dapper, F., & Hempelmann, G. (2019). The influence of acute preoperative plasmapheresis on coagulation tests, fibrinolysis, blood loss and transfusion requirements in cardiac surgery (Retraction of Vol 11, Pg 557, 1997). EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 55(5), 1024. doi:10.1093/ejcts/ezz079
Sepsis-associated coagulopathy and the association of platelet count with mortality
Welters, I. D. M., Waite, A., Alhamdi, Y., Abrams, S., Toh, C., Iqbal, R., & Venugopal, N. (2019). Sepsis-associated coagulopathy and the association of platelet count with mortality. In Critical Care Vol. 23, Suppl 2 (pp. 146). Brussels: Springer Nature.
A narrative review of diaphragm ultrasound to predict weaning from mechanical ventilation: where are we and where are we heading?
Welters, I., Turton, P., & ALAidarous, S. (2019). A narrative review of diaphragm ultrasound to predict weaning from mechanical ventilation: where are we and where are we heading?. The Ultrasound Journal. doi:10.1186/s13089-019-0117-8
Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome Insights from the LUNG SAFE Study
Tai, P., Neto, A. S., Pelosi, P., Laffey, J. G., De Haro, C., Angel Lorente, J., . . . Veljovic, M. (2019). Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome Insights from the LUNG SAFE Study. ANESTHESIOLOGY, 130(2), 263-283. doi:10.1097/ALN.0000000000002508
Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study*
van Haren, F., Pham, T., Brochard, L., Bellani, G., Laffey, J., Dres, M., . . . McAuley, D. (2019). Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study*. CRITICAL CARE MEDICINE, 47(2), 229-238. doi:10.1097/CCM.0000000000003519
2018
A survey of current attitudes to diaphragm ultrasound in the prediction of successful respiratory weaning.
Turton, P., & Welters, I. D. M. (2018). A survey of current attitudes to diaphragm ultrasound in the prediction of successful respiratory weaning.. Poster session presented at the meeting of Unknown Conference.
Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database
Boyle, A. J., Madotto, F., Laffey, J. G., Bellani, G., Tai, P., Pesenti, A., . . . McAuley, D. F. (2018). Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database. CRITICAL CARE, 22. doi:10.1186/s13054-018-2158-y
Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial
Calfee, C. S., Delucchi, K. L., Sinha, P., Matthay, M. A., Hackett, J., Shankar-Hari, M., . . . McAuley, D. F. (2018). Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. LANCET RESPIRATORY MEDICINE, 6(9), 691-698. doi:10.1016/S2213-2600(18)30177-2
Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries
Abe, T., Madotto, F., Pham, T., Nagata, I., Uchida, M., Tamiya, N., . . . Laffey, J. G. (2018). Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries. CRITICAL CARE, 22. doi:10.1186/s13054-018-2126-6
Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database
Cortegiani, A., Madotto, F., Gregoretti, C., Bellani, G., Laffey, J. G., Pham, T., . . . Grasselli, G. (2018). Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database. CRITICAL CARE, 22. doi:10.1186/s13054-018-2079-9
Outcomes in Patients with Vasodilatory Shock and Renal Replacement Therapy Treated with Intravenous Angiotensin II
Tumlin, J. A., Murugan, R., Deane, A. M., Ostermann, M., Busse, L. W., Ham, K. R., . . . Treatment, A. I. I. (2018). Outcomes in Patients with Vasodilatory Shock and Renal Replacement Therapy Treated with Intravenous Angiotensin II. CRITICAL CARE MEDICINE, 46(6), 949-957. doi:10.1097/CCM.0000000000003092
Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study
Madotto, F., Tai, P., Bellani, G., Bos, L. D., Simonis, F. D., Fan, E., . . . Laffey, J. G. (2018). Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study. INTENSIVE CARE MEDICINE, 44(5), 564-577. doi:10.1007/s00134-018-5152-6
Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP)
Vincent, J. -L., Lefrant, J. -Y., Kotfis, K., Nanchal, R., Martin-Loeches, I., Wittebole, X., . . . Sakr, Y. (2018). Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP). INTENSIVE CARE MEDICINE, 44(3), 337-344. doi:10.1007/s00134-017-5043-2
Angiotensin II for the Treatment of Vasodilatory Shock
Hemmy, D. (2018). Angiotensin II for the Treatment of Vasodilatory Shock. The Journal of Emergency Medicine, 54(1), 138-139. doi:10.1016/j.jemermed.2017.11.005
International survey on the perioperative management of pulmonary endarterectomy: the perfusion perspective
Stanzel, R. D. P., Gehron, J., Wolff, M., Striegl, N., Roth, P., Boedeker, R. -H., . . . Scheffler, M. (2018). International survey on the perioperative management of pulmonary endarterectomy: the perfusion perspective. PERFUSION-UK, 33(1), 53-61. doi:10.1177/0267659117724865
Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study (vol 42, pg 1865, 2016)
Laffey, J. G., Bellani, G., Pham, T., Fan, E., Madotto, F., Bajwa, E. K., . . . Pesenti, A. (2018). Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study (vol 42, pg 1865, 2016). INTENSIVE CARE MEDICINE, 44(1), 157-165. doi:10.1007/s00134-017-4981-z
2017
Current practice in the management of new-onset atrial fibrillation in critically ill patients: A UK-wide survey
Chean, C. S., McAuley, D. F., Gordon, A., & welters. (2017). Current practice in the management of new-onset atrial fibrillation in critically ill patients: A UK-wide survey. PeerJ.
Angiotensin II for the Treatment of Vasodilatory Shock
Khanna, A., English, S. W., Wang, X. S., Ham, K., Tumlin, J., Szerlip, H., . . . Deane, A. M. (2017). Angiotensin II for the Treatment of Vasodilatory Shock. NEW ENGLAND JOURNAL OF MEDICINE, 377(5), 419-430. doi:10.1056/NEJMoa1704154
Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study
Laffey, J. G., Madotto, F., Bellani, G., Pham, T., Fan, E., Brochard, L., . . . Pesenti, A. (2017). Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study. LANCET RESPIRATORY MEDICINE, 5(8), 627-638. doi:10.1016/S2213-2600(17)30213-8
Oxygen exchange and C-reactive protein predict safe discharge in patients with H1N1 influenza
Morton, B., Nweze, K., O'Connor, J., Turton, P., Joekes, E., Blakey, J. D., & Welters, I. D. (2017). Oxygen exchange and C-reactive protein predict safe discharge in patients with H1N1 influenza. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 110(4), 227-232. doi:10.1093/qjmed/hcw176
A case report: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS)
Welters, I. D. M. (2017, March 21). A case report: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). In Critical Care Vol. 21 (pp. P207). Brussels: BioMed Central.
A case report: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS)
Wall, R., & Welters, I. (2017, March 21). A case report: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). In Critical Care Vol. 21 (pp. P207). Brussels: BioMed Central.
Ascertaining correct placement of nasogastric tubes: a single-centre experience
Paisley, C., Patrick-Heselton, J., Mogk, M., Humphreys, J., & Welters, I. (2017). Ascertaining correct placement of nasogastric tubes: a single-centre experience. In Critical Care Vol. 21 (pp. P469). Brussels.
37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3)
Rob, D., Špunda, R., Lindner, J., Šmalcová, J., Šmíd, O., Kovárník, T., . . . Doyle, B. (2017). 37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3). Critical Care, 21(S1). doi:10.1186/s13054-017-1630-4
37th International Symposium on Intensive Care and Emergency Medicine (part 3 of 3)
Von Seth, M., Hillered, L., Otterbeck, A., Hanslin, K., Larsson, A., Sjölin, J., . . . O’Flynn, J. (2017). 37th International Symposium on Intensive Care and Emergency Medicine (part 3 of 3). Critical Care, 21(S1). doi:10.1186/s13054-017-1629-x
Elevated Circulating Histones Associate With Multiple Organ Dysfunction Syndromes in Acute Pancreatitis
Liu, T., Huang, W., Abrams, S., Wang, L., Szatmary, P., Alhamdi, Y., . . . Sutton, R. (2016). Elevated Circulating Histones Associate With Multiple Organ Dysfunction Syndromes in Acute Pancreatitis. PANCREAS, 45(10), 1520. Retrieved from https://www.webofscience.com/
Higher Fluid Balance Increases the Risk of Death From Sepsis: Results From a Large International Audit
Sakr, Y., Birri, P. N. R., Kotfis, K., Nanchal, R., Shah, B., Kluge, S., . . . Vincent, J. -L. (2017). Higher Fluid Balance Increases the Risk of Death From Sepsis: Results From a Large International Audit. CRITICAL CARE MEDICINE, 45(3), 386-394. doi:10.1097/CCM.0000000000002189
37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3) : Brussels, Belgium. 21-24 March 2017
Rob, D., Špunda, R., Lindner, J., Šmalcová, J., Šmíd, O., Kovárník, T., . . . Doyle, B. (2017). 37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3) : Brussels, Belgium. 21-24 March 2017. Critical care (London, England), 21(Suppl 1).
37th International Symposium on Intensive Care and Emergency Medicine (part 3 of 3) : Brussels, Belgium. 21-24 March 2017
37th International Symposium on Intensive Care and Emergency Medicine (part 3 of 3) : Brussels, Belgium. 21-24 March 2017 (2017). Critical care (London, England), 21(Suppl 1).
Noninvasive Ventilation of Patients with Acute Respiratory Distress Syndrome Insights from the LUNG SAFE Study
Bellani, G., Laffey, J. G., Tai, P., Madotto, F., Fan, E., Brochard, L., . . . Pesenti, A. (2017). Noninvasive Ventilation of Patients with Acute Respiratory Distress Syndrome Insights from the LUNG SAFE Study. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 195(1), 67-77. doi:10.1164/rccm.201606-1306OC
2016
Human limb skeletal muscle wasting and architectural remodeling during five to ten days intubation and ventilation in critical care - an observational study using ultrasound
Turton, P., Hay, R., Taylor, J., McPhee, J., & Welters, I. (2016). Human limb skeletal muscle wasting and architectural remodeling during five to ten days intubation and ventilation in critical care - an observational study using ultrasound. BMC ANESTHESIOLOGY, 16. doi:10.1186/s12871-016-0269-z
Epidemiological characteristics, practice of ventilation, and clinical outcome in patients at risk of acute respiratory distress syndrome in intensive care units from 16 countries (PRoVENT): an international, multicentre, prospective study.
Neto, A. S., Barbas, C. S. V., Simonis, F. D., Artigas-Raventós, A., Canet, J., Determann, R. M., . . . PROVE Network investigators. (2016). Epidemiological characteristics, practice of ventilation, and clinical outcome in patients at risk of acute respiratory distress syndrome in intensive care units from 16 countries (PRoVENT): an international, multicentre, prospective study.. The Lancet. Respiratory medicine, 4(11), 882-893. doi:10.1016/s2213-2600(16)30305-8
ESICM LIVES 2016: part one: Milan, Italy. 1-5 October 2016.
Bos, L., Schouten, L., van Vught, L., Wiewel, M., Ong, D., Cremer, O., . . . Weber, V. (2016). ESICM LIVES 2016: part one: Milan, Italy. 1-5 October 2016.. Intensive care medicine experimental, 4(Suppl 1), 1-203. doi:10.1186/s40635-016-0098-x
ESICM LIVES 2016: part one : Milan, Italy. 1-5 October 2016.
Bos, L., Schouten, L., van Vught, L., Wiewel, M., Ong, D., Cremer, O., . . . Weber, V. (2016). ESICM LIVES 2016: part one : Milan, Italy. 1-5 October 2016.. Intensive care medicine experimental, 4(Suppl 1), 27. doi:10.1186/s40635-016-0098-x
ESICM LIVES 2016: part three : Milan, Italy. 1-5 October 2016.
Velasquez, T., Mackey, G., Lusk, J., Kyle, U. G., Fontenot, T., Marshall, P., . . . Echeverri, J. E. (2016). ESICM LIVES 2016: part three : Milan, Italy. 1-5 October 2016.. Intensive care medicine experimental, 4(Suppl 1), 28. doi:10.1186/s40635-016-0100-7
ESICM LIVES 2016: part three : Milan, Italy. 1–5 October 2016
Velasquez, T., Mackey, G., Lusk, J., Kyle, U. G., Fontenot, T., Marshall, P., . . . Echeverri, J. E. (2016). ESICM LIVES 2016: part three : Milan, Italy. 1–5 October 2016. Intensive care medicine experimental, 4(Suppl 1).
Circulating Histone Concentrations Differentially Affect the Predominance of Left or Right Ventricular Dysfunction in Critical Illness
Alhamdi, Y., Zi, M., Abrams, S., Liu, T., Su, D., Welters, I., . . . Toh, C. -H. (2016). Circulating Histone Concentrations Differentially Affect the Predominance of Left or Right Ventricular Dysfunction in Critical Illness. Critical Care Medicine, 44(05), e278-e288. doi:10.1097/CCM.0000000000001413
36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016.
36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. (2016). Critical care (London, England), 20(Suppl 2), 94. doi:10.1186/s13054-016-1208-6
Accuracy of mortality prediction models in acute versus acute-on-chronic liver failure in the intensive care setting
Milinis, K., Cooper, M., Williams, G. R., McCarron, E., Simants, S., Patanwala, I., & Welters. (2016). Accuracy of mortality prediction models in acute versus acute-on-chronic liver failure in the intensive care setting. In Critical Care Vol. 20 (pp. P276). Brussels: BioMed Central.
Comparison of mortality prediction scoring systems in patients with cirrhosis admitted to general intensive care unit
Cooper, M., Milinis, K., Williams, G., McCarron, E., Simants, S., Patanwala, I., & Welters, I. (2016). Comparison of mortality prediction scoring systems in patients with cirrhosis admitted to general intensive care unit. In Critical Care Vol. 20 (pp. P388). Brussels: BioMed Central.
Disseminated intravascular coagulation (dic) is underdiagnosed in critically ill patients: do we need d-dimer measurements?
Iqbal, R., Alhamdi, Y., Venugopal, N., Abrams, S., Downey, C., Toh, C. H., & Welters, I. D. M. (2016). Disseminated intravascular coagulation (dic) is underdiagnosed in critically ill patients: do we need d-dimer measurements?. In Critical Care Vol. 20 (pp. P127). Brussels: BioMed Central.
Ketamine for analgosedation in severe hypoxic respiratory failure
Lee, S. D., Williams, K., & Welters, I. (2016). Ketamine for analgosedation in severe hypoxic respiratory failure. In Critical Care Vol. 20 (pp. P378). Brussels: BioMed Central.
Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries
Bellani, G., Laffey, J. G., Pham, T., Fan, E., Brochard, L., Esteban, A., . . . Pesenti, A. (2016). Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA: Journal of the American Medical Association, 315(8), 788-800. doi:10.1001/jama.2016.0291
36th International Symposium on Intensive Care and Emergency Medicine (vol 20, 94, 2016)
Iqbal, R., Alhamdi, Y., Venugopal, N., Abrams, S., Downey, C., Toh, C. H., & Welters, I. D. (2016). 36th International Symposium on Intensive Care and Emergency Medicine (vol 20, 94, 2016). CRITICAL CARE, 20. doi:10.1186/s13054-016-1358-6
AUGMENTED PASSIVE IMMUNOTHERAPY WITH P4 PEPTIDE IMPROVES PHAGOCYTE ACTIVITY IN SEVERE SEPSIS
Morton, B., Mitsi, E., Pennington, S. H., Reine, J., Wright, A. D., Parker, R., . . . Gordon, S. B. (2016). AUGMENTED PASSIVE IMMUNOTHERAPY WITH P4 PEPTIDE IMPROVES PHAGOCYTE ACTIVITY IN SEVERE SEPSIS. SHOCK, 46(6), 635-641. doi:10.1097/SHK.0000000000000715
Early prediction of major clinical outcomes of patients with acute pancreatitis by circulating histones
Liu, T., Huang, W., Szatmary, P., Abrams, S. T., Greenhalf, W., Welters, I., . . . Toh, C. H. (2016). Early prediction of major clinical outcomes of patients with acute pancreatitis by circulating histones. Pancreatology, 16(1), S34. doi:10.1016/j.pan.2015.12.107
2015
Lipopolysaccharide induces a downregulation of adiponectin receptors in-vitro and in-vivo
Hall, A., Leuwer, M., Trayhurn, P., & Welters, I. D. (2015). Lipopolysaccharide induces a downregulation of adiponectin receptors in-vitro and in-vivo. PEERJ, 3. doi:10.7717/peerj.1428
Exploring the translational disconnect between the murine and human inflammatory response: analysis of LPS dose-response relationship in murine versus human cell lines and implications for translation into murine models of sepsis.
McCarron, E. P., Williams, D. P., Antoine, D. J., Kipar, A., Lemm, J., Stehr, S., & Welters, I. D. (2015). Exploring the translational disconnect between the murine and human inflammatory response: analysis of LPS dose-response relationship in murine versus human cell lines and implications for translation into murine models of sepsis.. Journal of Inflammation Research, 8, 201-209. doi:10.2147/JIR.S89097
Circulating histones are major mediators of cardiac injury in patients with sepsis
Alhamdi, Y., Abrams, S. T., Cheng, Z., Jing, S., Su, D., Liu, Z., . . . Toh,, C. -H. (2015). Circulating histones are major mediators of cardiac injury in patients with sepsis. Critical Care Medicine, 43(10), 2094-2103. doi:10.1097/CCM.0000000000001162
Equipment-related critical incidents in a general intensive care unit
King, A. T., Wenstone, R., Morrison, J., Cloherty, L., & Welters, I. D. (2015). Equipment-related critical incidents in a general intensive care unit. Intensive care medicine experimental, 3(Suppl 1).
Low serum phosphate is not diagnostic for refeeding syndrome in critical care
Venugopal, N., Turner, P., Kolamunnage-Dono, R., Downey, C., & Welters, I. D. (2015). Low serum phosphate is not diagnostic for refeeding syndrome in critical care. Intensive care medicine experimental, 3(Suppl 1).
Retrospective consent in critical care: how achievable is it?
Carins, A., Shaw, D., Wright, A., Pearsons, D., Strong, A., Toh, C. H., & Welters, I. D. (2015). Retrospective consent in critical care: how achievable is it?. Intensive care medicine experimental, 3(Suppl 1).
Severe hypophosphatemia in the critically ill: are we replacing enough?
Millwood Hargrave, J., Agarwal, K., Ahmed, A., Toh, C. -H., Downey, C., & Welters, I. D. (2015). Severe hypophosphatemia in the critically ill: are we replacing enough?. Intensive care medicine experimental, 3(Suppl 1).
The fice course and qualification - experience from the cheshire and merseyside group
Dudziak, J., Bolton, N., McNeil, G., Paul, V., Raithatha, A., Rogers, G., . . . Tridente, A. (2015). The fice course and qualification - experience from the cheshire and merseyside group. Intensive care medicine experimental, 3(Suppl 1).
The fice course and qualification - experience from the cheshire and merseyside group.
Dudziak, J., Bolton, N., McNeil, G., Paul, V., Raithatha, A., Rogers, G., . . . Tridente, A. (2015). The fice course and qualification - experience from the cheshire and merseyside group.. Intensive care medicine experimental, 3(Suppl 1), A610. doi:10.1186/2197-425x-3-s1-a610
Time course and clinical relevance of thrombocytopenia in critical illness
Venugopal, N., Abrams, S., Alhamdi, Y., Downey, C., Toh, C. H., & Welters, I. D. (2015). Time course and clinical relevance of thrombocytopenia in critical illness. Intensive care medicine experimental, 3(Suppl 1).
doi:10.1186/2197-425x-3-s1-a85
The effect of the anticoagulation regimen on endothelial-related coagulation in cardiac surgery patients (Retraction of vol 50, pg 954, 1995)
Boldt, J., Schindler, E., Welters, I., Wittstock, M., Stertmann, W. A., & Hempelmann, G. (2015). The effect of the anticoagulation regimen on endothelial-related coagulation in cardiac surgery patients (Retraction of vol 50, pg 954, 1995). ANAESTHESIA, 70(9), 1104. doi:10.1111/anae.13188
CONFOCAL ENDOMICROSCOPY DEMONSTRATES INCREASED INTESTINAL PERMEABILITY AND GUT DYSFUNCTION IN PATIENTS WITH ACUTE AND CHRONIC PANCREATITIS
Bharucha, S., Geraghty, J., Duckworth, C., Armstrong, J., Szatmary, P., Winn, S., . . . Sutton, R. (2015). CONFOCAL ENDOMICROSCOPY DEMONSTRATES INCREASED INTESTINAL PERMEABILITY AND GUT DYSFUNCTION IN PATIENTS WITH ACUTE AND CHRONIC PANCREATITIS. In GUT Vol. 64 (pp. A307). doi:10.1136/gutjnl-2015-309861.663
Circulating histones contribute to acute respiratory distress syndrome in acute pancreatitis
Liu, T., Abrams, S., Szatmary, P., Cheng, Z., Huang, W., Ou, X., . . . Toh, C. -H. (2015). Circulating histones contribute to acute respiratory distress syndrome in acute pancreatitis. Pancreatology, 15(3), S63. doi:10.1016/j.pan.2015.05.242
Performance of influenza-specific triage tools in an H1N1-positive cohort: P/F ratio better predicts the need for mechanical ventilation and critical care admission
Morton, B., Tang, L., Gale, R., Kelly, M., Robertson, H., Mogk, M., . . . Welters, I. (2015). Performance of influenza-specific triage tools in an H1N1-positive cohort: P/F ratio better predicts the need for mechanical ventilation and critical care admission. British Journal of Anaesthesia, 114(6), 927-933. doi:10.1093/bja/aev042
760 Confocal Endomicroscopy Demonstrates Increased Intestinal Permeability and Gut Dysfunction in Patients With Acute and Chronic Pancreatitis
Bharucha, S., Geraghty, J., Duckworth, C. A., Armstrong, J., Szatmary, P., Winn, S. A., . . . Sutton, R. (2015). 760 Confocal Endomicroscopy Demonstrates Increased Intestinal Permeability and Gut Dysfunction in Patients With Acute and Chronic Pancreatitis. Gastroenterology, 148(4), S-145. doi:10.1016/s0016-5085(15)30495-9
Circulating histones disturb intracellular calcium homeostasis and cause calcium overload to induce cardiovascular abnormalities in sepsis
Alhamdi, Y., Abrams, S. T., Zi, M., Welters, I., Cartwright, E. J., Wang, G., & Toh, C. -H. (2015). Circulating histones disturb intracellular calcium homeostasis and cause calcium overload to induce cardiovascular abnormalities in sepsis. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13, 159. Retrieved from https://www.webofscience.com/
Developing a laboratory-based score to predict mortality in patients admitted to the ICU
Iqbal, A., Welters, I., Kolamunnage-Dona, R., Toh, C., & Downey, C. (2015). Developing a laboratory-based score to predict mortality in patients admitted to the ICU. Critical care (London, England), 19(Suppl 1), P547. doi:10.1186/cc14627
Effect of prolonged critical care admissions on upper and lower limb muscle architecture
Turton, P., Hay, R., Taylor, J. K., Little, J., McPhee, J., & Welters, I. (2015). Effect of prolonged critical care admissions on upper and lower limb muscle architecture. Critical care (London, England), 19(Suppl 1), P473. doi:10.1186/cc14553
Equipment-related critical incidents in a general intensive care unit
King, A. T., Wenstone, R., Morrison, J., Cloherty, L., & Welters, I. D. (2015). Equipment-related critical incidents in a general intensive care unit. Intensive Care Medicine Experimental, 3(S1). doi:10.1186/2197-425x-3-s1-a70
Low serum phosphate is not diagnostic for refeeding syndrome in critical care
Venugopal, N., Turner, P., Kolamunnage-Dono, R., Downey, C., & Welters, I. D. (2015). Low serum phosphate is not diagnostic for refeeding syndrome in critical care. Intensive Care Medicine Experimental, 3(S1). doi:10.1186/2197-425x-3-s1-a282
doi:10.1186/2197-425x-3-s1-a138
doi:10.1186/2197-425x-3-s1-a913
2014
Simvastatin in the acute respiratory distress syndrome.
McAuley, D. F., Laffey, J. G., O'Kane, C. M., Perkins, G. D., Mullan, B., Trinder, T. J., . . . Irish Critical Care Trials Group. (2014). Simvastatin in the acute respiratory distress syndrome.. The New England journal of medicine, 371(18), 1695-1703. doi:10.1056/nejmoa1403285
Myocardial Injury after Noncardiac Surgery A Large, International, Prospective Cohort Study Establishing Diagnostic Criteria, Characteristics, Predictors, and 30-day Outcomes
Botto, F., Alonso-Coello, P., Chan, M. T. V., Carlos Villar, J., Xavier, D., Srinathan, S., . . . Wildes, T. (2014). Myocardial Injury after Noncardiac Surgery A Large, International, Prospective Cohort Study Establishing Diagnostic Criteria, Characteristics, Predictors, and 30-day Outcomes. ANESTHESIOLOGY, 120(3), 564-578. doi:10.1097/ALN.0000000000000113
Circulating anti-inflammatory adipokines High Molecular Weight Adiponectin and Zinc-α2-glycoprotein (ZAG) are inhibited in early sepsis, but increase with clinical recovery: a pilot study
Welters, I. D., Bing, C., Ding, C., Leuwer, M., & Hall, A. M. (2014). Circulating anti-inflammatory adipokines High Molecular Weight Adiponectin and Zinc-α2-glycoprotein (ZAG) are inhibited in early sepsis, but increase with clinical recovery: a pilot study. BMC ANESTHESIOLOGY, 14. doi:10.1186/1471-2253-14-124
Endogenous morphine-6-glucuronide (M6G) is present in the plasma of patients: Validation of a specific anti-M6G antibody for clinical and basic research
Laux-Biehlmann, A., Chung, H., Mouheiche, J., Veriepe, J., Delalande, F., Lamshoeft, M., . . . Garnero, P. (2014). Endogenous morphine-6-glucuronide (M6G) is present in the plasma of patients: Validation of a specific anti-M6G antibody for clinical and basic research. BIOFACTORS, 40(1), 113-120. doi:10.1002/biof.1107
2013
Assessment and clinical course of hypocalcemia in critical illness
Steele, T., Kolamunnage-Dona, R., Downey, C., Toh, C. -H., & Welters, I. (2013). Assessment and clinical course of hypocalcemia in critical illness. CRITICAL CARE, 17(3). doi:10.1186/cc12756
Intensive care admission after cardiac arrest: cardiac versus noncardiac causes and consequences for treatment
Hargreaves, T., Kingston, H., Crews, M., Mogk, M., & Welters, I. (2013). Intensive care admission after cardiac arrest: cardiac versus noncardiac causes and consequences for treatment. Critical Care, 17(S2). doi:10.1186/cc12245
Albumin-adjusted calcium concentration should not be used to identify hypocalcaemia in critical illness
Steele, T., Kolamunnage-Dona, R., Downey, C., Toh, C., & Welters, I. (2013). Albumin-adjusted calcium concentration should not be used to identify hypocalcaemia in critical illness. Critical care (London, England), 17(Suppl 2), P446. doi:10.1186/cc12384
Correspondence Regarding: BIS Monitoring in Intensive Care
Hampshire, P. A., Guha, A. K., Poole, L. A., Welters, I. D., & Murphy, J. (2013). Correspondence Regarding: BIS Monitoring in Intensive Care. Journal of the Intensive Care Society, 14(4), 366-367. doi:10.1177/175114371301400428
Exploring the translational disconnect between the murine and human inflammatory response: analysis of the dose-response relationship of LPS and NFκB activation in murine and human immune cells.
McCarron, E. P., Welters, I., Williams, D., Antoine, D., & Kipar, A. (2013). Exploring the translational disconnect between the murine and human inflammatory response: analysis of the dose-response relationship of LPS and NFκB activation in murine and human immune cells.. Critical care (London, England), 17(Suppl 2), P18. doi:10.1186/cc11956
Intensive care admission after cardiac arrest: cardiac versus noncardiac causes and consequences for treatment
Hargreaves, T., Kingston, H., Crews, M., Mogk, M., & Welters, I. (2013). Intensive care admission after cardiac arrest: cardiac versus noncardiac causes and consequences for treatment. Critical care (London, England), 17(Suppl 2), P307.
2012
Comparison of serum and lithium-heparinate plasma for the accurate measurements of endogenous and exogenous morphine concentrations
Laux-Biehlmann, A., Graefe, N., Mouheiche, J., Stuber, D., Welters, I. D., Delalande, F., . . . Goumon, Y. (2012). Comparison of serum and lithium-heparinate plasma for the accurate measurements of endogenous and exogenous morphine concentrations. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 74(2), 381-383. doi:10.1111/j.1365-2125.2012.04199.x
Association Between Postoperative Troponin Levels and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery (vol 307, pg 2295, 2012)
Devereaux, P. J. (2012). Association Between Postoperative Troponin Levels and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery (vol 307, pg 2295, 2012). JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 307(24), 2590. doi:10.1001/jama.2012.6889
Error in Viewpoint in: Statin Therapy for Healthy Men Identified as ‘Increased Risk,’
Error in Viewpoint in: Statin Therapy for Healthy Men Identified as ‘Increased Risk,’ (2012). JAMA, 307(24), 2590. doi:10.1001/jama.2012.6832
Outcome of faecal peritonitis in the ICU
Sayer, J., Simpson, G., Mccrossan, L., & Welters, I. (2012). Outcome of faecal peritonitis in the ICU. Critical Care, 16(S1). doi:10.1186/cc11005
Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery.
Vascular Events In Noncardiac Surgery Patients Cohort Evaluation., Devereaux, P. J., Chan, M. T., Alonso-Coello, P., Walsh, M., Berwanger, O., . . . Yusuf, S. (2012). Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery.. JAMA, 307(21), 2295-2304.
Central venous catheter placement: where is the end of the line?
Tizard, K., & Welters, I. (2012). Central venous catheter placement: where is the end of the line?. Critical care (London, England), 16(Suppl 1), P208. doi:10.1186/cc10815
Echocardiography in the ICU: an audit of 3 years practice
Hall, A., Walker, J., & Welters, I. (2012). Echocardiography in the ICU: an audit of 3 years practice. Critical care (London, England), 16(Suppl 1), P192. doi:10.1186/cc10799
Liver failure secondary to alcoholic liver disease carries a worse prognosis than other aetiologies of liver failure: retrospective analysis of routine biochemical markers in critically ill patients with liver failure
McCarron, E., & Welters, I. (2012). Liver failure secondary to alcoholic liver disease carries a worse prognosis than other aetiologies of liver failure: retrospective analysis of routine biochemical markers in critically ill patients with liver failure. Critical care (London, England), 16(Suppl 1), P391. doi:10.1186/cc10998
Outcome of faecal peritonitis in the ICU
Sayer, J., Simpson, G., Mccrossan, L., & Welters, I. (2012). Outcome of faecal peritonitis in the ICU. Critical care (London, England), 16(Suppl 1), P398.
2011
Major sources of critical incidents in intensive care
Welters, I. D., Gibson, J., Mogk, M., & Wenstone, R. (2011). Major sources of critical incidents in intensive care. CRITICAL CARE, 15(5). doi:10.1186/cc10474
The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis
Perez-Casal, M., Thompson, V., Downey, C., Welters, I., Wyncoll, D., Thachil, J., & Toh, C. H. (2011). The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis. CRITICAL CARE, 15(4). doi:10.1186/cc10356
Pyruvate: immunonutritional effects on neutrophil intracellular amino or alpha-keto acid profiles and reactive oxygen species production
Mathioudakis, D., Engel, J., Welters, I. D., Dehne, M. G., Matejec, R., Harbach, H., . . . Muhling, J. (2011). Pyruvate: immunonutritional effects on neutrophil intracellular amino or alpha-keto acid profiles and reactive oxygen species production. AMINO ACIDS, 40(4), 1077-1090. doi:10.1007/s00726-010-0731-z
Bispectral index monitoring reduces sedative and vasopressor requirements during percutaneous tracheostomy
Hampshire, P., Guha, A., Welters, I., Murphy, J., & Poole, L. (2011). Bispectral index monitoring reduces sedative and vasopressor requirements during percutaneous tracheostomy. Critical care (London, England), 15(Suppl 1), P348. doi:10.1186/cc9768
Continuous <i>S</i>-(+)- ketamine administration during elective coronary artery bypass graft surgery attenuates pro-inflammatory cytokine response during and after cardiopulmonary bypass
Welters, I. D., Feurer, M. -K., Preiss, V., Mueller, M., Scholz, S., Kwapisz, M., . . . Neuhaeuser, C. (2011). Continuous <i>S</i>-(+)- ketamine administration during elective coronary artery bypass graft surgery attenuates pro-inflammatory cytokine response during and after cardiopulmonary bypass. BRITISH JOURNAL OF ANAESTHESIA, 106(2), 172-179. doi:10.1093/bja/aeq341
Hemodynamic Actions of Corticotropin-Releasing Hormone and Proopiomelanocortin Derivatives in Septic Patients
Matejec, R., Loecke, G., Kayser, F., Lichtenstern, C., Weigand, M. A., Welters, I. D., . . . Harbach, H. -W. (2011). Hemodynamic Actions of Corticotropin-Releasing Hormone and Proopiomelanocortin Derivatives in Septic Patients. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 57(1), 94-102. doi:10.1097/FJC.0b013e3181fffe00
Investigation and management of hypocalcaemia amongst critically ill patients
Carins, A., Mogk, M., & Welters, I. D. (2011). Investigation and management of hypocalcaemia amongst critically ill patients. Critical care (London, England), 15(Suppl 1), P370. doi:10.1186/cc9790
Reply from the authors
Welters, I. D., & Neuhäuser, C. (2011). Reply from the authors. British Journal of Anaesthesia, 107(5), 813-814. doi:10.1093/bja/aer321
The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis
Pérez-Casal, M., Thompson, V., Downey, C., Welters, I., Wyncoll, D., Thachil, J., & Toh, C. H. (n.d.). The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis. Critical Care, 15(4). doi:10.1186/cc10356
2010
Ketamine Inhibits Transcription Factors Activator Protein 1 and Nuclear Factor-κB, Interleukin-8 Production, as well as CD11b and CD16 Expression: Studies in Human Leukocytes and Leukocytic Cell Lines
Welters, I. D., Hafer, G., Menzebach, A., Muehling, J., Neuhaeuser, C., Browning, P., & Goumon, Y. (2010). Ketamine Inhibits Transcription Factors Activator Protein 1 and Nuclear Factor-κB, Interleukin-8 Production, as well as CD11b and CD16 Expression: Studies in Human Leukocytes and Leukocytic Cell Lines. ANESTHESIA AND ANALGESIA, 110(3), 934-941. doi:10.1213/ANE.0b013e3181c95cfa
Endogenous Morphine Levels Are Increased in Sepsis: A Partial Implication of Neutrophils
Glattard, E., Welters, I. D., Lavaux, T., Muller, A. H., Laux, A., Zhang, D., . . . Goumon, Y. (2010). Endogenous Morphine Levels Are Increased in Sepsis: A Partial Implication of Neutrophils. PLOS ONE, 5(1). doi:10.1371/journal.pone.0008791
Effects of α-ketoglutarate on neutrophil intracellular amino and α-keto acid profiles and ROS production
Muehling, J., Tussing, F., Nickolaus, K. A., Matejec, R., Henrich, M., Harbach, H., . . . Heidt, M. C. (2010). Effects of α-ketoglutarate on neutrophil intracellular amino and α-keto acid profiles and ROS production. AMINO ACIDS, 38(1), 167-177. doi:10.1007/s00726-008-0224-5
LB035 NUTRITION AND TRACE ELEMENTS IN INTENSIVE CARE UNIT ACQUIRED WEAKNESS
Strang, R., Turner, P., Shenkin, A., Mogk, M., & Welters, I. (2010). LB035 NUTRITION AND TRACE ELEMENTS IN INTENSIVE CARE UNIT ACQUIRED WEAKNESS. Clinical Nutrition Supplements, 5(2), 208-209. doi:10.1016/s1744-1161(10)70547-0
2009
Hemodynamic effects of dobutamine and dopexamine after cardiopulmonary bypass in pediatric cardiac surgery*
Kwapisz, M. M., Neuhaeuser, C., Scholz, S., Welters, I. D., Loehr, T., Koch, T., . . . Mueller, M. (2009). Hemodynamic effects of dobutamine and dopexamine after cardiopulmonary bypass in pediatric cardiac surgery*. PEDIATRIC ANESTHESIA, 19(9), 862-871. doi:10.1111/j.1460-9592.2009.03101.x
Endotoxaemia leads to major increases in inflammatory adipokine gene expression in white adipose tissue of mice
Leuwer, M., Welters, I., Marx, G., Rushton, A., Bao, H., Hunter, L., & Trayhurn, P. (2009). Endotoxaemia leads to major increases in inflammatory adipokine gene expression in white adipose tissue of mice. Pflügers Archiv - European Journal of Physiology, 457(4), 731-741. doi:10.1007/s00424-008-0564-8
Endotoxaemia leads to major increases in inflammatory adipokine gene expression in white adipose tissue of mice
Leuwer, M., Welters, I., Marx, G., Rushton, A., Bao, H., Hunter, L., & Trayhurn, P. (2009). Endotoxaemia leads to major increases in inflammatory adipokine gene expression in white adipose tissue of mice. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 457(4), 731-741. doi:10.1007/s00424-008-0564-8
Chapter 10 General anesthetics and therapeutic gases
Welters, I. D., & Leuwer, M. (2009). Chapter 10 General anesthetics and therapeutic gases. In Unknown Book (Vol. 31, pp. 217-229). Elsevier. doi:10.1016/s0378-6080(09)03110-9
General anesthetics and therapeutic gases
Welters, I. D., & Leuwer, M. (2009). General anesthetics and therapeutic gases. In SIDE EFFECTS OF DRUGS ANNUAL: A WORLDWIDE YEARLY SURVEY OF NEW DATA AND TRENDS IN ADVERSE DRUG REACTIONS (Vol. 31, pp. 217-229). doi:10.1016/S0378-6080(09)03110-9
Intracellular alpha-keto acid quantification by fluorescence-HPLC
Fuchs, M., Engel, J., Campos, M., Matejec, R., Henrich, M., Harbach, H., . . . Muehling, J. (2009). Intracellular alpha-keto acid quantification by fluorescence-HPLC. AMINO ACIDS, 36(1), 1-11. doi:10.1007/s00726-008-0033-x
2008
Can biochemical markers be used to predict the rate of achieving tight glycaemic control in critically ill adults?
Turner, P., Sanusi, A., Perry, B., Shenkin, A., & Welters, I. (2008). Can biochemical markers be used to predict the rate of achieving tight glycaemic control in critically ill adults?. Proceedings of the Nutrition Society, 67(OCE3). doi:10.1017/s0029665100591356
Can biochemical markers be used to predict the rate of achieving tight glycaemic control in critically ill adults?
Turner, P., Sanusi, A., Perry, B., Shenkin, A., & Welters, I. (2008). Can biochemical markers be used to predict the rate of achieving tight glycaemic control in critically ill adults?. Proceedings of the Nutrition Society, 67(OCE3). doi:10.1017/s0029665108007829
Which mechanisms are involved in taurine-dependent granulocytic immune response or amino- and α-keto acid homeostasis?
Muelling, J., Nickolaus, K. A., Matejec, R., Langefeld, T. W., Harbach, H., Engel, J., . . . Hempelmann, G. (2008). Which mechanisms are involved in taurine-dependent granulocytic immune response or amino- and α-keto acid homeostasis?. AMINO ACIDS, 34(2), 257-270. doi:10.1007/s00726-007-0497-0
10 General anesthetics and therapeutic gases
Welters, I. D., & Leuwer, M. (2008). 10 General anesthetics and therapeutic gases. In Side Effects of Drugs Annual (Vol. 30, pp. 137-151). doi:10.1016/S0378-6080(08)00010-X
Comparison of S-(+)-ketamine- with sufentanil-based anaesthesia for elective coronary artery bypass graft surgery:: effect on troponin T levels
Neuhaeuser, C., Preiss, V., Feurer, M. -K., Mueller, M., Scholz, S., Kwapisz, M., . . . Welters, I. D. (2008). Comparison of S-(+)-ketamine- with sufentanil-based anaesthesia for elective coronary artery bypass graft surgery:: effect on troponin T levels. BRITISH JOURNAL OF ANAESTHESIA, 100(6), 765-771. doi:10.1093/bja/aen095
General anesthetics and therapeutic gases
Welters, I. D., & Leuwer, M. (2008). General anesthetics and therapeutic gases. In SIDE EFFECTS OF DRUGS ANNUAL 30: A WORLDWIDE YEARLY SURVEY OF NEW DATA AND TRENDS IN ADVERSE DRUG REACTIONS AND INTERACTIONS (Vol. 30, pp. 137-151). doi:10.1016/S0378-6080(08)00010-X
Response of proopiomelanocortin and gonado- or lactotroph systems to in-vitro fertilisation procedures stress
Harbach, H., Antrecht, K., Boedeker, R. -H., Brenck, F., Gips, H., Hempelmann, G., . . . Zygmunt, M. (2008). Response of proopiomelanocortin and gonado- or lactotroph systems to in-vitro fertilisation procedures stress. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 141(2), 137-142. doi:10.1016/j.ejogrb.2008.08.001
Response to delivery stress is not mediated by beta-endorphin (1-31)
Harbach, H., Antrecht, K., Boedeker, R. -H., Hempelmann, G., Markart, P., Matejec, R., . . . Zygmunt, M. (2008). Response to delivery stress is not mediated by beta-endorphin (1-31). EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 136(1), 39-45. doi:10.1016/j.ejogrb.2007.02.004
2007
Functional significance of ACTH and β-endorphin for the proopiomelanocortin and immune response to stress
Harbach, H., Hempelmann, G., Matejec, R., Langefeld, T. W., Menzebach, A., & Welters, I. D. (2007). Functional significance of ACTH and β-endorphin for the proopiomelanocortin and immune response to stress. Anasthesiologie und Intensivmedizin, 48(11), 592-603.
Morphine inhibits AP-1 activity and CD 14 expression in leukocytes by a nitric oxide and opioid receptor-dependent mechanism
Welters, I. D., Menzebach, A., Goumon, Y., Langefeld, T. W., Harbach, H., Muehling, J., . . . Stefano, G. B. (2007). Morphine inhibits AP-1 activity and CD 14 expression in leukocytes by a nitric oxide and opioid receptor-dependent mechanism. EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 24(11), 958-965. doi:10.1017/S026502150700083X
Pathways involved in alanyl-glutamine-induced changes in neutrophil amino- and α-keto acid homeostasis or immunocompetence
Muehling, J., Burchert, D., Langefeld, T. W., Matejec, R., Harbach, H., Engel, J., . . . Hempelmann, G. (2007). Pathways involved in alanyl-glutamine-induced changes in neutrophil amino- and α-keto acid homeostasis or immunocompetence. AMINO ACIDS, 33(3), 511-524. doi:10.1007/s00726-006-0395-x
Communication with patients during ward rounds on the intensive care unit: a prospective, observational, semiblind study
Francis, K., Langhor, D., Walker, J., & Welters, I. (2007). Communication with patients during ward rounds on the intensive care unit: a prospective, observational, semiblind study. Critical care (London, England), 11(Suppl 2), P498.
Intensive insulin therapy and indications for intensive care admission
Sanusi, A., Welters, I., Shenkin, A., Turner, P., & Perry, B. (2007). Intensive insulin therapy and indications for intensive care admission. Critical care (London, England), 11(Suppl 2), P135.
Intravenous anesthesia with S-(+)-ketamine for 'on-pump' coronary artery bypass surgery: hemodynamic profile and effect on troponin T levels
Neuhaeuser, C., Preiss, V., Mueller, M., Scholz, S., Kwapizs, M., & Welters, I. (2007). Intravenous anesthesia with S-(+)-ketamine for 'on-pump' coronary artery bypass surgery: hemodynamic profile and effect on troponin T levels. Critical care (London, England), 11(Suppl 2), P431.
2006
Effect of Isoflurane on echocardiographic left-ventricular relaxation indices in patients with diastolic dysfunction due to concentric hypertrophy and ischemic heart disease
Neuhaeuser, C., Mueller, M., Welters, I., Scholz, S., & Kwapisz, M. M. (2006). Effect of Isoflurane on echocardiographic left-ventricular relaxation indices in patients with diastolic dysfunction due to concentric hypertrophy and ischemic heart disease. JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 20(4), 509-514. doi:10.1053/j.jvca.2006.01.018
Nitric oxide and polyamine pathway-dependent modulation of neutrophil free amino- and α-keto acid profiles or host defense capability
Muehling, J., Engel, J., Halabi, M., Mueller, M., Fuchs, M., Kruell, M., . . . Hempelmann, G. (2006). Nitric oxide and polyamine pathway-dependent modulation of neutrophil free amino- and α-keto acid profiles or host defense capability. AMINO ACIDS, 31(1), 11-26. doi:10.1007/s00726-006-0273-6
Performance and customization of 4 prognostic models for postoperative onset of nausea and vomiting in ear, nose, and throat surgery
Engel, J. M., Junger, A., Hartmann, B., Little, S., Schnoebel, R., Mann, V., . . . Hempelmann, G. (2006). Performance and customization of 4 prognostic models for postoperative onset of nausea and vomiting in ear, nose, and throat surgery. JOURNAL OF CLINICAL ANESTHESIA, 18(4), 256-263. doi:10.1016/j.jclinane.2005.10.003
Thiopentone reduces neutrophil receptor expression
Welters, I., Hafer, G., Muehling, J., Engel, J., & Hempelmann, G. (2006). Thiopentone reduces neutrophil receptor expression. European Journal of Anaesthesiology, 23(Supplement 37), 150-151. doi:10.1097/00003643-200606001-00540
Identification of morphine-6-glucuronide in chromaffin cell secretory granules
Goumon, Y., Muller, A., Glattard, E., Marban, C., Gasnier, C., Strub, J. M., . . . Metz-Boutigue, M. H. (2006). Identification of morphine-6-glucuronide in chromaffin cell secretory granules. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(12), 8082-8089. doi:10.1074/jbc.M502298200
Comparison of three scoring systems in medical intensive care patients
Welters, I. D., Röhrig, R., Sander, O., Mogk, M., & Sparenborg, H. (2006). Comparison of three scoring systems in medical intensive care patients. Intensive Care Med, 32(Suppl.), S59.
2005
Alterations in neutrophil (PMN) free intracellular alpha-keto acid profiles and immune functions induced by L-alanyl-L-glutamine, arginine or taurine
Mühling, J., Nickolaus, K. A., Halabi, M., Fuchs, M., Krüll, M., Engel, J., . . . Hempelmann, G. (2005). Alterations in neutrophil (PMN) free intracellular alpha-keto acid profiles and immune functions induced by L-alanyl-L-glutamine, arginine or taurine. AMINO ACIDS, 29(3), 289-300. doi:10.1007/s00726-005-0223-8
Activation of Granulocytes and Antiproteases in open heart surgery
Welters, I. D., Hirsch, J., Menzebach, A., Hempelmann, G., & Müller, M. (2005). Activation of Granulocytes and Antiproteases in open heart surgery. ANASTHESIOLOGIE INTENSIVMEDIZIN NOTFALLMEDIZIN SCHMERZTHERAPIE, 40(3), 164-172. doi:10.1055/s-2005-861042
Benzodiazepine receptor-dependent modulation of neutrophil (PMN) free amino- and α-keto acid profiles or immune functions
Mühling, J., Gonter, J., Nickolaus, K. A., Matejec, R., Welters, I. D., Wolff, M., . . . Hempelmann, G. (2005). Benzodiazepine receptor-dependent modulation of neutrophil (PMN) free amino- and α-keto acid profiles or immune functions. AMINO ACIDS, 28(1), 85-98. doi:10.1007/s00726-004-0136-y
Impact of prolonged elevated heart rate on incidence of major cardiac events in critically ill patients with a high risk of cardiac complications
Sander, O., Welters, I. D., Foëk, P., & Sear, J. W. (2005). Impact of prolonged elevated heart rate on incidence of major cardiac events in critically ill patients with a high risk of cardiac complications. CRITICAL CARE MEDICINE, 33(1), 81-88. doi:10.1097/01.CCM.0000150028.64264.14
Morphine inhibits AP-1 nuclear binding in human leukocytes
Welters, I. D., Menzebach, A., Engel, J., Mühling, J., & Hempelmann, G. (2005). Morphine inhibits AP-1 nuclear binding in human leukocytes. Intensive Care Med, 31, S72.
2004
Effects of ornithine on neutrophil (PMN) free amino acid and α-keto acid profiles and immune functions <i>in vitro</i>
Mühling, J., Fuchs, M., Campos, M., Gonter, J., Sablotzki, A., Engel, J., . . . Hempelmann, G. (2004). Effects of ornithine on neutrophil (PMN) free amino acid and α-keto acid profiles and immune functions <i>in vitro</i>. AMINO ACIDS, 27(3-4), 313-319. doi:10.1007/s00726-004-0126-0
ACE inhibitors enalaprilat and quinaprilat inhibit monocyte surface receptor expression
Welters, I. D., Reyher, C., Hafer, G., Hempelmann, G., Menzebach, A., Müller, M., & Heidt, M. C. (2004). ACE inhibitors enalaprilat and quinaprilat inhibit monocyte surface receptor expression. European Journal of Anaesthesiology, 21(Supplement 33), 7. doi:10.1097/00003643-200406001-00017
Inhaled iloprost in the management of pulmonary hypertension in infants undergoing congenital heart surgery
Mueller, M., Neuhaeuser, C., Noest, R., Akintuerk, H., Welters, I., & Hempelmann, G. (2004). Inhaled iloprost in the management of pulmonary hypertension in infants undergoing congenital heart surgery. European Journal of Anaesthesiology, 21(Supplement 33), 3. doi:10.1097/00003643-200406001-00006
Morphine inhibits complement receptor expression, phagocytosis and oxidative burst by a nitric oxide dependant mechanism
Menzebach, A., Hirsch, J., Nöst, R., Mogk, M., Hempelmann, G., & Welters, I. D. (2004). Morphine inhibits complement receptor expression, phagocytosis and oxidative burst by a nitric oxide dependant mechanism. ANASTHESIOLOGIE INTENSIVMEDIZIN NOTFALLMEDIZIN SCHMERZTHERAPIE, 39(4), 204-211. doi:10.1055/s-2004-814389
The hippocampal cholinergic neurostimulating peptide, the N-terminal fragment of the secreted phosphatidylethanolamine-binding protein, possesses a new biological activity on cardiac physiology
Goumon, Y., Angelone, T., Schoentgen, F. O., Chasserot-Golaz, S., Almas, B., Fukami, M. M., . . . Metz-Boutigue, M. H. (2004). The hippocampal cholinergic neurostimulating peptide, the N-terminal fragment of the secreted phosphatidylethanolamine-binding protein, possesses a new biological activity on cardiac physiology. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(13), 13054-13064. doi:10.1074/jbc.M308533200
2003
Effects of endogenous and synthetic opioid peptides on neutrophil function <i>in vitro</i>
Menzebach, A., Hirsch, J., Hempelmann, G., & Welters, I. D. (2003). Effects of endogenous and synthetic opioid peptides on neutrophil function <i>in vitro</i>. BRITISH JOURNAL OF ANAESTHESIA, 91(4), 546-550. doi:10.1093/bja/aeg219
Is immunomodulation by opioid drugs of clinical relevance?
Welters, I. D. (2003). Is immunomodulation by opioid drugs of clinical relevance?. CURRENT OPINION IN ANESTHESIOLOGY, 16(5), 509-513. doi:10.1097/00001503-200310000-00011
Indicators of erythrocyte damage after microwave warming of packed red blood cells
Hirsch, J., Menzebach, A., Welters, I. D., Dietrich, G. V., Katz, N., & Hempelmann, G. (2003). Indicators of erythrocyte damage after microwave warming of packed red blood cells. CLINICAL CHEMISTRY, 49(5), 792-799. doi:10.1373/49.5.792
Opioids and immunosuppression. Clinical relevance?
Welters, I. (2003). Opioids and immunosuppression. Clinical relevance?. ANAESTHESIST, 52(5), 442-452. doi:10.1007/s00101-003-0506-y
Temperature course and distribution during plasma heating with a microwave device
Hirsch, J., Bach, R., Menzebach, A., Welters, I. D., Dietrich, G. V., & Hempelmann, G. (2003). Temperature course and distribution during plasma heating with a microwave device. ANAESTHESIA, 58(5), 444-447. doi:10.1046/j.1365-2044.2003.03086.x
2001
Inhibitory effects of S-(-) and R-(+) bupivacaine on neutrophil function
Welters, I. D., Menzebach, A., Langefeld, T. W., Menzebach, M., & Hempelmann, G. (2001). Inhibitory effects of S-(-) and R-(+) bupivacaine on neutrophil function. ACTA ANAESTHESIOLOGICA SCANDINAVICA, 45(5), 570-575. doi:10.1034/j.1399-6576.2001.045005570.x
Influence of colloid fluids on polymorphonuclear granulocyte function <i>in vivo</i>
Engel, J. M., Welters, I., Rupp, M., Langefeld, T., Ruwoldt, R., Menges, T., & Hempelmann, G. (2001). Influence of colloid fluids on polymorphonuclear granulocyte function <i>in vivo</i>. ACTA ANAESTHESIOLOGICA SCANDINAVICA, 45(3), 385-389. doi:10.1034/j.1399-6576.2001.045003385.x
2000
Processing of proenkephalin-A in bovine chromaffin cells - Identification of natural derived fragments by N-terminal sequencing and matrix-assisted laser desorption ionization-time of flight mass spectrometry
Goumon, Y., Lugardon, K., Gadroy, P., Strub, J. M., Welters, I. D., Stefano, G. B., . . . Metz-Boutigue, M. H. (2000). Processing of proenkephalin-A in bovine chromaffin cells - Identification of natural derived fragments by N-terminal sequencing and matrix-assisted laser desorption ionization-time of flight mass spectrometry. JOURNAL OF BIOLOGICAL CHEMISTRY, 275(49), 38355-38362. doi:10.1074/jbc.M007557200
Morphine suppresses complement receptor expression, phagocytosis, and respiratory burst in neutrophils by a nitric oxide and μ<sub>3</sub> opiate receptor-dependent mechanism
Welters, I. D., Menzebach, A., Goumon, Y., Langefeld, T. W., Teschemacher, H., Hempelmann, G., & Stefano, G. B. (2000). Morphine suppresses complement receptor expression, phagocytosis, and respiratory burst in neutrophils by a nitric oxide and μ<sub>3</sub> opiate receptor-dependent mechanism. JOURNAL OF NEUROIMMUNOLOGY, 111(1-2), 139-145. doi:10.1016/S0165-5728(00)00401-X
Endogenous morphine
Stefano, G. B., Goumon, Y., Casares, F., Cadet, P., Fricchione, G. L., Rialas, C., . . . Bianchi, E. (2000). Endogenous morphine. TRENDS IN NEUROSCIENCES, 23(9), 436-442. doi:10.1016/S0166-2236(00)01611-8
<i>Ascaris suum</i>, an intestinal parasite, produces morphine
Goumon, Y., Casares, F., Pryor, S., Ferguson, L., Brownawell, B., Cadet, P., . . . Stefano, G. B. (2000). <i>Ascaris suum</i>, an intestinal parasite, produces morphine. JOURNAL OF IMMUNOLOGY, 165(1), 339-343. doi:10.4049/jimmunol.165.1.339
Estradiol-stimulated nitric oxide release in human granulocytes is dependent on intracellular calcium transients: evidence of a cell surface estrogen receptor.
Stefano, G. B., Cadet, P., Breton, C., Goumon, Y., Prevot, V., Dessaint, J. P., . . . Salzet, M. (2000). Estradiol-stimulated nitric oxide release in human granulocytes is dependent on intracellular calcium transients: evidence of a cell surface estrogen receptor.. Blood, 95(12), 3951-3958.
Morphine inbibits NF-κB nuclear binding in human neutrophils and monocytes by a nitric oxide-dependent mechanism
Welters, I. D., Menzebach, A., Goumon, Y., Cadet, P., Menges, T., Hughes, T. K., . . . Stefano, G. B. (2000). Morphine inbibits NF-κB nuclear binding in human neutrophils and monocytes by a nitric oxide-dependent mechanism. ANESTHESIOLOGY, 92(6), 1677-1684. doi:10.1097/00000542-200006000-00027
Antagonism of LPS and IFN-γ induced iNOS expression in human atrial endothelia by morphine, anandamide, and estrogen
Fimiani, C., Magazine, H., Welters, I. D., Bilfinger, T. V., Salsano, F., Tonnesen, E., & Stefano, G. B. (2000). Antagonism of LPS and IFN-γ induced iNOS expression in human atrial endothelia by morphine, anandamide, and estrogen. ACTA PHARMACOLOGICA SINICA, 21(5), 405-409. Retrieved from https://www.webofscience.com/
Cell-surface estrogen receptors mediate calcium-dependent nitric oxide release in human endothelia
Stefano, G. B., Prevot, V., Beauvillain, J. C., Cadet, P., Fimiani, C., Welters, I., . . . Bilfinger, T. V. (2000). Cell-surface estrogen receptors mediate calcium-dependent nitric oxide release in human endothelia. CIRCULATION, 101(13), 1594-1597. doi:10.1161/01.CIR.101.13.1594
Basal nitric oxide limits immune, nervous and cardiovascular excitation: human endothelia express a mu opiate receptor
Stefano, G. B., Goumon, Y., Bilfinger, T. V., Welters, I. D., & Cadet, P. (2000). Basal nitric oxide limits immune, nervous and cardiovascular excitation: human endothelia express a mu opiate receptor. PROGRESS IN NEUROBIOLOGY, 60(6), 513-530. doi:10.1016/S0301-0082(99)00038-6
Reduction of Postoperative Nausea and Vomiting by Dimenhydrinate Suppositories after Strabismus Surgery in Children
Welters, I. D., Menges, T., Gräf, M., Beikirch, C., Menzebach, A., & Hempelmann, G. (2000). Reduction of Postoperative Nausea and Vomiting by Dimenhydrinate Suppositories after Strabismus Surgery in Children. Anesthesia & Analgesia, 90(2), 311-314. doi:10.1213/00000539-200002000-00013
Postoperative nausea and vomiting after Faden operation
Welters, I. D., Graef, M., Menges, T., Beikirch, C., Kaufmann, H., & Hempelmann, G. (2000). Postoperative nausea and vomiting after Faden operation. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 238(1), 59-63. doi:10.1007/s004170050010
Influence of kolloids on neutrophil function
Welters, I. D., Spangenberg, U., Menzebach, A., Engel, J., Menges, T., Langefeld, T. W., & Hempelmann, G. (2000). Influence of kolloids on neutrophil function. ANAESTHESIST, 49(3), 196-201. doi:10.1007/s001010050814
NF-κB, nitric oxide and opiate signaling
Welters, I. D., Fimiani, C., Bilfinger, T. V., & Stefano, G. B. (2000). NF-κB, nitric oxide and opiate signaling. MEDICAL HYPOTHESES, 54(2), 263-268. doi:10.1054/mehy.1999.0032
Reduction of postoperative nausea and vomiting by dimenhydrinate suppositories after strabismus surgery in children
Welters, I. D., Menges, T., Gräf, M., Beikirch, C., Menzebach, A., & Hempelmann, G. (2000). Reduction of postoperative nausea and vomiting by dimenhydrinate suppositories after strabismus surgery in children. ANESTHESIA AND ANALGESIA, 90(2), 311-314. doi:10.1097/00000539-200002000-00013
1999
Estradiol coupling to human monocyte nitric oxide release is dependent on intracellular calcium transients: Evidence for an estrogen surface receptor
Stefano, G. B., Prevot, V., Beauvillain, J. C., Fimiani, C., Welters, I., Cadet, P., . . . Bilfinger, T. V. (1999). Estradiol coupling to human monocyte nitric oxide release is dependent on intracellular calcium transients: Evidence for an estrogen surface receptor. JOURNAL OF IMMUNOLOGY, 163(7), 3758-3763. Retrieved from https://www.webofscience.com/
Changes in blood lymphocyte populations after multiple trauma: Association with posttraumatic complications
Menges, T., Engel, J., Welters, I., Wagner, R. M., Little, S., Ruwoldt, R., . . . Hempelmann, G. (1999). Changes in blood lymphocyte populations after multiple trauma: Association with posttraumatic complications. CRITICAL CARE MEDICINE, 27(4), 733-740. doi:10.1097/00003246-199904000-00026
1998
Thrombin generation and activation of the thrombomodulin protein C system in open heart surgery depend on the underlying cardiac disease
Welters, I., Menges, T., Ballesteros, M., Knothe, C., Ruwoldt, R., Görlach, G., & Hempelmann, G. (1998). Thrombin generation and activation of the thrombomodulin protein C system in open heart surgery depend on the underlying cardiac disease. THROMBOSIS RESEARCH, 92(1), 1-9. doi:10.1016/S0049-3848(98)00095-4
Acute phase and opsonin response in cardiac surgery patients: influence of underlying cardiac disease
Welters, I., Menges, T., Ballesteros, M., Sablotzki, A., Goerlach, G., & Hempelmann, G. (1998). Acute phase and opsonin response in cardiac surgery patients: influence of underlying cardiac disease. PERFUSION-UK, 13(6), 447-454. doi:10.1177/026765919801300608
1997
Development of an algorithm for optimising plasmapheresis filters
Dietrich, G. V., Heinbuch, G., Welters, I., Menges, T., & Hempelmann, G. (1997). Development of an algorithm for optimising plasmapheresis filters. Infusionstherapie und Transfusionsmedizin, 24(4), 307.
Effect of intravascular volume load after induction of anaesthesia on oxygen consumption in cardiac surgery patients
Ballesteros, M., Welters, I., Boldt, J., Zickmann, B., Knothe, C., & Hempelmann, G. (1997). Effect of intravascular volume load after induction of anaesthesia on oxygen consumption in cardiac surgery patients. In British Journal of Anaesthesia Vol. 79 (pp. 10).
Plasma levels of immunoinhibitory cytokines interleukin-10 and transforming growth factor-beta in patients undergoing coronary artery bypass grafting
Sablotzki, A., Welters, I., Lehmann, N., Menges, T., Gorlach, G., Dehne, M., & Hempelmann, G. (1997). Plasma levels of immunoinhibitory cytokines interleukin-10 and transforming growth factor-beta in patients undergoing coronary artery bypass grafting. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 11(4), 763-768. doi:10.1016/S1010-7940(97)01154-8
ASSOCIATION OF A BI-ALLELIC NCOI POLYMORPHISM WITHIN THE TNF LOCUS WITH THE PROGNOSIS AND OUTCOME OF SEVERELY INJURED TRAUMA PATIENTS
Menges, T., Gronau, S., Kostrezewa, M., Welters, I., Little, S. G., Wagner, R. M., . . . Hempelmann, G. (1997). ASSOCIATION OF A BI-ALLELIC NCOI POLYMORPHISM WITHIN THE TNF LOCUS WITH THE PROGNOSIS AND OUTCOME OF SEVERELY INJURED TRAUMA PATIENTS. Shock, 7(Supplement), 17. doi:10.1097/00024382-199703001-00070
The influence of acute preoperative plasmapheresis on coagulation tests, fibrinolysis, blood loss and transfusion requirements in cardiac surgery (Retracted article. See vol. 55, pg. 1024, 2019)
Menges, T., Welters, I., Wagner, R. M., Boldt, J., Dapper, F., & Hempelmann, G. (1997). The influence of acute preoperative plasmapheresis on coagulation tests, fibrinolysis, blood loss and transfusion requirements in cardiac surgery (Retracted article. See vol. 55, pg. 1024, 2019). EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 11(3), 557-563. doi:10.1016/S1010-7940(96)01093-7
Alterations of the cytokine network in patients undergoing cardiopulmonary bypass
Sablotzki, A., Dehne, M., Welters, I., Menges, T., Lehmann, N., Goerlach, G., . . . Hempelmann, G. (1997). Alterations of the cytokine network in patients undergoing cardiopulmonary bypass. PERFUSION-UK, 12(6), 393-403. doi:10.1177/026765919701200608
Can albumin reduce platelet damage during extracorporeal circulation?
Welters, I., Menges, T., Zickmann, B., Knothe, C., & Hempelmann, G. (1997). Can albumin reduce platelet damage during extracorporeal circulation?. In British Journal of Anaesthesia Vol. 79 (pp. 36).
Concentration of cefamandole in plasma and tissues of patients undergoing cardiac surgery: The influence of different cefamandole dosage
Menges, T., Sablotzki, A., Welters, I., Wagner, R. M., Zickmann, B., Gronau, S., . . . Hempelmann, G. (1997). Concentration of cefamandole in plasma and tissues of patients undergoing cardiac surgery: The influence of different cefamandole dosage. JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 11(5), 565-570. doi:10.1016/S1053-0770(97)90005-7
Thrombin generation and protein C activation in cardiac surgery patients
Welters, I., Menges, T., Knothe, C., Ballesteros, M., & Hempelmann, G. (1997). Thrombin generation and protein C activation in cardiac surgery patients. In British Journal of Anaesthesia Vol. 79 (pp. 11).
1996
Free Papers
Emmanuel, G., Carranza, S., Vettichira, S., Paradis, M., Lie, T., Kessler, P., . . . Vanderkelen, A. (1996). Free Papers. Intensive Care Medicine, 22(S3), S339-S344. doi:10.1007/bf03216428
Changes of neopterin, soluble interleukin-2 receptor, interleukin-2 and interleukin-6 in patients undergoing coronary artery bypass grafting
Sablotzki, A., Welters, I., Menges, T., Lehmann, N., Gorlach, G., Hehrlein, F. W., & Hempelmann, G. (1996). Changes of neopterin, soluble interleukin-2 receptor, interleukin-2 and interleukin-6 in patients undergoing coronary artery bypass grafting. Cor Europaeum - European Journal of Cardiac Interventions, 5(3), 106-109.
Influence of long-term continuous intravenous administration of pentoxifylline on endothelial-related coagulation in critically ill patients
Boldt, J., Muller, M., Heyn, S., Welters, I., & Hempelmann, G. (1996). Influence of long-term continuous intravenous administration of pentoxifylline on endothelial-related coagulation in critically ill patients. CRITICAL CARE MEDICINE, 24(6), 940-946. doi:10.1097/00003246-199606000-00011
Normothermic versus hypothermic cardiopulmonary bypass: Do changes in coagulation differ? (Retracted article. See vol. 111, 2021)
Boldt, J., Knothe, C., Welters, I., Dapper, F. L., & Hempelmann, G. (1996). Normothermic versus hypothermic cardiopulmonary bypass: Do changes in coagulation differ? (Retracted article. See vol. 111, 2021). ANNALS OF THORACIC SURGERY, 62(1), 130-135. doi:10.1016/0003-4975(96)00239-1
The role the protein C-thrombomodulin system and fibrinolysis during cardiovascular surgery: Influence of acute preoperative plasmapheresis
Menges, T., Wagner, R. M., Welters, I., Ruwoldt, R., Boldt, J., & Hempelmann, G. (1996). The role the protein C-thrombomodulin system and fibrinolysis during cardiovascular surgery: Influence of acute preoperative plasmapheresis. JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 10(4), 482-489. doi:10.1016/S1053-0770(05)80009-6
1995
[Effect of controlled hypotension using sodium nitroprusside on platelet aggregation].
Heesen, M., Dietrich, G. V., Wirth, R., Ballesteros, M., Welters, I., & Hempelmann, G. (1995). [Effect of controlled hypotension using sodium nitroprusside on platelet aggregation].. Revista espanola de anestesiologia y reanimacion, 42(8), 320-323.
DOES THE TYPE OF VOLUME THERAPY INFLUENCE ENDOTHELIAL-RELATED COAGULATION IN THE CRITICALLY ILL (Retracted article. See vol. 125, pg. 415, 2020)
BOLDT, J., HEESEN, M., WELTERS, I., PADBERG, W., MARTIN, K., & HEMPELMANN, G. (1995). DOES THE TYPE OF VOLUME THERAPY INFLUENCE ENDOTHELIAL-RELATED COAGULATION IN THE CRITICALLY ILL (Retracted article. See vol. 125, pg. 415, 2020). BRITISH JOURNAL OF ANAESTHESIA, 75(6), 740-746. doi:10.1093/bja/75.6.740
ENDOTHELIAL-RELATED COAGULATION IN CARDIAC-SURGERY (Retracted article. See vol. 125, pg. 415, 2020)
BOLDT, J., SCHINDLER, E., KNOTHE, C., WELTERS, I., STERTMANN, W. A., & HEMPELMANN, G. (1995). ENDOTHELIAL-RELATED COAGULATION IN CARDIAC-SURGERY (Retracted article. See vol. 125, pg. 415, 2020). BRITISH JOURNAL OF ANAESTHESIA, 74(2), 174-179. doi:10.1093/bja/74.2.174
THE EFFECT OF THE ANTICOAGULATION REGIMEN ON ENDOTHELIAL-RELATED COAGULATION IN CARDIAC-SURGERY PATIENTS (Retracted article. See vol. 70, pg. 1104, 2015)
BOLDT, J., SCHINDLER, E., WELTERS, I., WITTSTOCK, M., STERTMANN, W. A., & HEMPELMANN, G. (1995). THE EFFECT OF THE ANTICOAGULATION REGIMEN ON ENDOTHELIAL-RELATED COAGULATION IN CARDIAC-SURGERY PATIENTS (Retracted article. See vol. 70, pg. 1104, 2015). ANAESTHESIA, 50(11), 954-960. doi:10.1111/j.1365-2044.1995.tb05927.x
1994
Intracranial bleeding and hemostasis. Improved management of patients with intracranial bleeding by measurements of activation products of coagulation and its control
Menges, T., Lessen, V. A., Welters, I., Wagner, R. M., Ruwoldt, R., Boldt, J., & Hempelmann, G. (1994). Intracranial bleeding and hemostasis. Improved management of patients with intracranial bleeding by measurements of activation products of coagulation and its control. Infusionstherapie und Transfusionsmedizin, 21(4), 244-250.
INTRACRANIAL BLEEDING AND HEMOSTASIS - IMPROVED MANAGEMENT OF PATIENTS WITH INTRACRANIAL BLEEDING BY MEASUREMENTS OF ACTIVATION PRODUCTS OF COAGULATION AND ITS CONTROL
MENGES, T., VONLESSEN, A., WELTERS, I., WAGNER, R. M., RUWOLDT, R., BOLDT, J., & HEMPELMANN, G. (1994). INTRACRANIAL BLEEDING AND HEMOSTASIS - IMPROVED MANAGEMENT OF PATIENTS WITH INTRACRANIAL BLEEDING BY MEASUREMENTS OF ACTIVATION PRODUCTS OF COAGULATION AND ITS CONTROL. INFUSIONSTHERAPIE UND TRANSFUSIONSMEDIZIN, 21(4), 244-250. Retrieved from https://www.webofscience.com/
1993
THE INFLUENCE OF DIFFERENT METHODS OF AUTOLOGOUS BLOOD-TRANSFUSION ON PLASMA-LEVELS OF ANTIBIOTICS - STUDY OF THE CEPHALOSPORINE CEFAMANDOLE
MENGES, T., BOLDT, J., SCHOLZ, K., WAGNER, R. M., RUWOLDT, R., WELTERS, I., & HEMPELMANN, G. (1993). THE INFLUENCE OF DIFFERENT METHODS OF AUTOLOGOUS BLOOD-TRANSFUSION ON PLASMA-LEVELS OF ANTIBIOTICS - STUDY OF THE CEPHALOSPORINE CEFAMANDOLE. ANAESTHESIST, 42(8), 509-515. Retrieved from https://www.webofscience.com/