Research
Medicinal Chemistry of Anti-Infectives
Chemical Biology
Synthetic Organic Chemistry
Research groups
Research grants
Lead Optimisation of a Series of Antimalarial Plasmepsin IX/X Betahydroxyethylamine Based Inhibitors
MEDICAL RESEARCH COUNCIL
February 2024 - January 2026
Development of non-covalent binders to SOD1 with scope for developing as PROTAC degraders of SOD1 for the treatment of MND
MOTOR NEURONE DISEASE ASSOCIATION (UK)
October 2023 - January 2027
Phase II Clinical Development of AWZ1066S, a Small Molecule anti-Wolbachia Candidate Macrofilaricide Drug
GLOBAL HEALTH INNOVATIVE TECHNOLOGY FUND - GHIT (JAPAN)
October 2022 - September 2024
Defining the two-step relay mechanism of action of the 8-aminoquinolines: A precondition for optimal combination therapies for relapse malaria
MEDICAL RESEARCH COUNCIL
September 2021 - September 2024
Drug discovery to inhibit cyclophilin D as a treatment for acute pancreatitis
LAP RESEARCH (UK)
September 2022 - August 2024
Design and development of novel SOD1 degraders for the treatment of Motor Neurone Disease
ROYAL SOCIETY OF CHEMISTRY (UK)
September 2022 - August 2023
An anti-Wolbachia azaquinazoline small molecule as a preventative drug candidate for veterinary heartworm disease
ROYAL VETERINARY COLLEGE(UK)
November 2021 - September 2022
Optimisation of the Antimalarial and DMPK Properties of A Series of Plasmepsin IX/X Beta-hydroxyethylamine Based Inhibitors
LIVERPOOL SCHOOL OF TROPICAL MEDICINE (UK)
March 2021 - August 2022
New combination therapy against MDR TB targeting the respiratory chain
MEDICAL RESEARCH COUNCIL
March 2019 - February 2022
LSTM MRC-CiC Determining the potency of hybrid antibiotics, informed by collateral sensitivity networks, against a panel of susceptible and resistant clinical Escherichia coli isolates.
LIVERPOOL SCHOOL OF TROPICAL MEDICINE (UK)
October 2018 - October 2019
Development of Small Molecule Inhibitors of the Mitochondrial Electron Transport Chain of Plasmodium falciparum
DEPARTMENT FOR BUSINESS, ENERGY AND INDUSTRIAL STRATEGY (BEIS) (UK)
March 2018 - January 2021
Pre-Clinical Development of small molecule anti-Wolbachia candidate macrofilaricide drug
MEDICAL RESEARCH COUNCIL
September 2018 - September 2020
A new generation of Crystallographic detector for Multi-user Barkla X-ray laboratory
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
July 2017 - July 2018
Rational Design, Synthesis and Biological Evaluation of Benzimidazoles Towards a Novel Therapy Selectively Targeting C. neoformans beta-tubulin
MEDICAL RESEARCH COUNCIL
July 2016 - December 2019
Positive Allosteric Modulators of Strychnine-Sensitive Glycine Receptors – A New Concept in Treating Chronic Pain
MEDICAL RESEARCH COUNCIL
September 2012 - February 2015
A new drug target against Malaria
LEVERHULME TRUST (UK)
June 2006 - May 2009
Resistant Breaking Insecticides - Project New Pyrethroids
BAYER CORPORATION (USA)
December 2007 - December 2011
Synthesis and Biomimetic Chemistry of Novel Antimalarial Endoperoxide Cysteine Protease Inhibitor (ECPI) Pro-Drugs.
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
September 2000 - August 2003
400 MHz NMR Spectrometer.
ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL
March 2000 - February 2003
Alternative complex 1 as a drug target in malaria
WELLCOME TRUST (UK)
December 2008 - September 2011
Lead Series Development & Optimisation af a New Drug Against Active and Latent Tuberculosis.
MEDICAL RESEARCH COUNCIL
October 2011 - March 2014
Defining the mechanism of action of the 8-aminoquinolines: A pre-requisite to rationally designed safe antimalarials for the elimination era
MEDICAL RESEARCH COUNCIL
August 2014 - December 2016
University of Liverpool Institutional Discipline Bridging.
MEDICAL RESEARCH COUNCIL
October 2003 - October 2006
Quantitative high-throughput proteomics for biomedical research.
MEDICAL RESEARCH COUNCIL
March 2005 - March 2008
Synthesis and biological evaluation of primaquine metabolites: implications of safety and efficacy
MEDICINES FOR MALARIA VENTURE (SWITZERLAND)
July 2014 - July 2015
Cloning and characterisation of enzymes required for the in vitro synthesis of the antimalarial artemisinin.
MEDICAL RESEARCH COUNCIL
September 2002 - August 2003
Probing the molecular mechanism of action of novel antimalarial falcipain 2 inhibitor endoperoxide pro-drugs in isolated parasite digestive vacuoles.
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
March 2005 - February 2008
Development of New Drugs for the Treatment of Malaria (ANTIMAL)
EUROPEAN COMMISSION
December 2005 - May 2011
TCAMS triazole series as potential serine protease inhibitors.
TRES CANTOS OPEN LAB FOUNDATION (UK)
October 2012 - September 2014
Bridging and accelerating the translation of novel scientific findings for health and wealth gain
MEDICAL RESEARCH COUNCIL
March 2014 - August 2015
KEL09/13 - Molecular design and chemoinformatics: A combined approach to novel molecules
ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL
December 2010 - March 2012
Towards a 21st Century Replacement for the 4-Aminoquinoline Chloroquine
ROYAL SOCIETY (CHARITABLE)
July 2006
Co(II)L2 Mediated Catalytic Aerobic Asymmetric Peroxysilylation and Hydration of Unactivated Alkenes.
ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL
November 2000 - October 2002