Publications
Selected publications
- AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis (Journal article - 2019)
- A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance (Journal article - 2017)
- Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7 (Journal article - 2016)
- Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides (Journal article - 2019)
- A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile (Journal article - 2016)
- Antimalarial activity of primaquine operates via a two-step biochemical relay (Journal article - 2019)
- Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives (Journal article - 2021)
- Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid (Journal article - 2021)
- Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205 (Journal article - 2021)
- Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in <i>Plasmodium falciparum</i>. (Journal article - 2024)
2024
Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in <i>Plasmodium falciparum</i>.
Lisauskaitė, M., Nixon, G. L., Woodley, C. M., Berry, N. G., Coninckx, A., Qie, L. C., . . . O'Neill, P. M. (2024). Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in <i>Plasmodium falciparum</i>.. RSC chemical biology, 5(1), 19-29. doi:10.1039/d3cb00109a
2023
Thiazolide Prodrug Esters and Derived Peptides: Synthesis and Activity.
Stachulski, A. V., Rossignol, J. -F., Pate, S., Taujanskas, J., Iggo, J. A., Aerts, R., . . . O'Neill, P. M. (2023). Thiazolide Prodrug Esters and Derived Peptides: Synthesis and Activity.. ACS bio & med chem Au, 3(4), 327-334. doi:10.1021/acsbiomedchemau.2c00083
Transformation of the Manufacturing Process from Discovery to Kilogram Scale for AWZ1066S: A Highly Specific Anti-Wolbachia Drug Candidate for a Short-Course Treatment of Filariasis
Hong, W. D., O'Neill, P. M., Taylor, M. J., Turner, J. D., Ward, S. A., Gusovsky, F., . . . Khile, A. S. (2023). Transformation of the Manufacturing Process from Discovery to Kilogram Scale for AWZ1066S: A Highly Specific Anti-Wolbachia Drug Candidate for a Short-Course Treatment of Filariasis. ORGANIC PROCESS RESEARCH & DEVELOPMENT. doi:10.1021/acs.oprd.2c00167
Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis
Jeffreys, L. N., Ardrey, A., Hafiz, T. A., Dyer, L. -A., Warman, A. J., Mosallam, N., . . . Biagini, G. A. (2023). Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis. ACS INFECTIOUS DISEASES. doi:10.1021/acsinfecdis.2c00283
2022
Recent Advances of DprE1 Inhibitors against<i> Mycobacterium</i><i> tuberculosis:</i> Computational Analysis of Physicochemical and ADMET Properties
Amado, P. S. M., Woodley, C., Cristiano, M. L. S., & O'Neill, P. M. (2022). Recent Advances of DprE1 Inhibitors against<i> Mycobacterium</i><i> tuberculosis:</i> Computational Analysis of Physicochemical and ADMET Properties. ACS OMEGA. doi:10.1021/acsomega.2c05307
Design, Synthesis, and Study of a Novel RXPA380-Proline Hybrid (RXPA380-P) as an Antihypertensive Agent
Abdou, M. M., Dong, D., O'Neill, P. M., Amigues, E., & Matziari, M. (2022). Design, Synthesis, and Study of a Novel RXPA380-Proline Hybrid (RXPA380-P) as an Antihypertensive Agent. ACS OMEGA, 7(39), 35035-35043. doi:10.1021/acsomega.2c03813
2021
Machine learning-Predicting Ames mutagenicity of small molecules
Chu, C. S. M., Simpson, J. D., O'Neill, P. M., & Berry, N. G. (2021). Machine learning-Predicting Ames mutagenicity of small molecules. JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 109. doi:10.1016/j.jmgm.2021.108011
Artemisinin inspired synthetic endoperoxide drug candidates: Design, synthesis, and mechanism of action studies
Woodley, C. M., Amado, P. S. M., Cristiano, M. L. S., & O'Neill, P. M. (2021). Artemisinin inspired synthetic endoperoxide drug candidates: Design, synthesis, and mechanism of action studies. MEDICINAL RESEARCH REVIEWS, 41(6), 3062-3095. doi:10.1002/med.21849
Synthesis, antiviral activity, preliminary pharmacokinetics and structural parameters of thiazolide amine salts
Stachulski, A. V., Rossignol, J. -F., Pate, S., Taujanskas, J., Robertson, C. M., Aerts, R., . . . O'Neill, P. M. (2021). Synthesis, antiviral activity, preliminary pharmacokinetics and structural parameters of thiazolide amine salts. FUTURE MEDICINAL CHEMISTRY, 13(20). doi:10.4155/fmc-2021-0055
Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis
McGillan, P., Berry, N. G., Nixon, G. L., Leung, S. C., Webborn, P. J. H., Wenlock, M. C., . . . O’Neill, P. M. (2021). Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis. ACS Medicinal Chemistry Letters, 12(9), 1421-1426. doi:10.1021/acsmedchemlett.1c00216
Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid
Amado, P. S. M., Frija, L. M. T., Coelho, J. A. S., O’Neill, P. M., & Cristiano, M. L. S. (2021). Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid. The Journal of Organic Chemistry, 86(15), 10608-10620. doi:10.1021/acs.joc.1c01258
Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid
Amado, P. S. M., Frija, L. M. T., Coelho, J. A. S., O'Neill, P. M., & Cristiano, M. L. S. (2021). Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid. JOURNAL OF ORGANIC CHEMISTRY, 86(15), 10608-10620. doi:10.1021/acs.joc.1c01258
Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205
Woodley, C. M., Nixon, G. L., Basilico, N., Parapini, S., Hong, W. D., Ward, S. A., . . . O'Neill, P. M. (2021). Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205. ACS MEDICINAL CHEMISTRY LETTERS, 12(7), 1077-1085. doi:10.1021/acsmedchemlett.1c00031
Anti-Wolbachia drugs for filariasis
Johnston, K. L., Hong, W. D., Turner, J. D., O'Neill, P. M., Ward, S. A., & Taylor, M. J. (2021). Anti-Wolbachia drugs for filariasis. TRENDS IN PARASITOLOGY, 37(12), 1068-1081. doi:10.1016/j.pt.2021.06.004
Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives
Amporndanai, K., Meng, X., Shang, W., Jin, Z., Zhao, Y., Rao, Z., . . . Rogers, M. (2021). Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-23313-7
Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis
Rajoli, R. K. R., Pertinez, H., Arshad, U., Box, H., Tatham, L., Curley, P., . . . Owen, A. (2021). Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(4), 2078-2088. doi:10.1111/bcp.14619
2020
Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis
Amporndanai, K., Rogers, M., Watanabe, S., Yamanaka, K., O'Neill, P. M., & Hasnain, S. S. (2020). Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis. EBIOMEDICINE, 59. doi:10.1016/j.ebiom.2020.102980
Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter <i>Trypanosoma brucei</i>
Alghamdi, A. H., Munday, J. C., Campagnaro, G. D., Gurvic, D., Svensson, F., Okpara, C. E., . . . De Koning, H. P. (2020). Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter <i>Trypanosoma brucei</i>. ELIFE, 9. doi:10.7554/eLife.56416
Prioritisation of Anti-SARS-Cov-2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics.
Arshad, U., Pertinez, H., Box, H., Tatham, L., Rajoli, R. K., Curley, P., . . . Owen, A. (2020). Prioritisation of Anti-SARS-Cov-2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics.. Clinical pharmacology and therapeutics. doi:10.1002/cpt.1909
Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis.
Rajoli, R. K., Pertinez, H., Arshad, U., Box, H., Tatham, L., Curley, P., . . . Owen, A. (2020). Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis.. medRxiv : the preprint server for health sciences. doi:10.1101/2020.05.01.20087130
Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy
Chantadul, V., Wright, G. S. A., Amporndanai, K., Shahid, M., Antonyuk, S. V., Washbourn, G., . . . Hasnain, S. S. (2020). Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy. COMMUNICATIONS BIOLOGY, 3(1). doi:10.1038/s42003-020-0826-3
2019
Synthesis of MeBmt and related derivatives via syn-selective ATH-DKR
Rolt, A., O'Neill, P. M., Liang, T. J., & Stachulski, A. V. (2019). Synthesis of MeBmt and related derivatives via syn-selective ATH-DKR. RSC ADVANCES, 9(69), 40336-40339. doi:10.1039/c9ra08256e
Antimalarial activity of primaquine operates via a two-step biochemical relay
Camarda, G., Jirawatcharadech, P., Priestley, R. S., Saif, A., March, S., Wong, M. H. L., . . . Biagini, G. A. (2019). Antimalarial activity of primaquine operates via a two-step biochemical relay. NATURE COMMUNICATIONS, 10. doi:10.1038/s41467-019-11239-0
Control and regulation of S‐Adenosylmethionine biosynthesis by the regulatory β subunit and quinolone‐based compounds
Panmanee, J., Bradley-Clarke, J., Mato, J. M., O'Neill, P. M., Antonyuk, S. V., & Hasnain, S. S. (2019). Control and regulation of S‐Adenosylmethionine biosynthesis by the regulatory β subunit and quinolone‐based compounds. The Federation of European Biochemical Societies (FEBS) Journal, 286(11), 2135-2154. doi:10.1111/febs.14790
Phosphinic acids: current status and potential for drug discovery
Abdou, M. M., O'Neill, P. M., Amigues, E., & Matziari, M. (2019). Phosphinic acids: current status and potential for drug discovery. DRUG DISCOVERY TODAY, 24(3), 916-929. doi:10.1016/j.drudis.2018.11.016
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis
Hong, W. D., Benayoud, F., Nixon, G. L., Ford, L., Johnston, K. L., Clare, R. H., . . . O'Neill, P. M. (2019). AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(4), 1414-1419. doi:10.1073/pnas.1816585116
Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides
Clare, R. H., Bardelle, C., Harper, P., Hong, W. D., Borjesson, U., Johnston, K. L., . . . Ward, S. A. (2019). Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides. NATURE COMMUNICATIONS, 10. doi:10.1038/s41467-018-07826-2
A NEW RAPID ACTING ANTI-WOLBACHIA DRUG FOR ONCHOCERCIASIS AND LYMPHATIC FILARIASIS
Hong, W. D., Johnston, K. L., Berry, N. G., Gusovsky, F., Heming-Way, J., Turner, J. D., . . . O'Neill, P. M. (2019). A NEW RAPID ACTING ANTI-WOLBACHIA DRUG FOR ONCHOCERCIASIS AND LYMPHATIC FILARIASIS. In TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE Vol. 113 (pp. S4). Retrieved from https://www.webofscience.com/
2018
Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties
David Hong, W., Leung, S. C., Amporndanai, K., Davies, J., Priestley, R. S., Nixon, G. L., . . . O'Neill, P. M. (2018). Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties. ACS Medicinal Chemistry Letters, 9(12), 1205-1210. doi:10.1021/acsmedchemlett.8b00371
α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy
Wong, S. Q., Pontifex, M. G., Phelan, M. M., Pidathala, C., Kraemer, B. C., Barclay, J. W., . . . Morgan, A. (2018). α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy. Neurobiology of disease, 118, 40-54. doi:10.1016/j.nbd.2018.06.013
Study of the antimalarial activity of 4-aminoquinoline compounds against chloroquine-sensitive and chloroquine-resistant parasite strains
Lawrenson, A. S., Cooper, D. L., O'Neill, P. M., & Berry, N. G. (2018). Study of the antimalarial activity of 4-aminoquinoline compounds against chloroquine-sensitive and chloroquine-resistant parasite strains. JOURNAL OF MOLECULAR MODELING, 24(9). doi:10.1007/s00894-018-3755-z
Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria
O' Neill, P. M., Stocks, P. A., Sabbani, S., Roberts, N. L., Amewu, R. K., Shore, E. R., . . . Ward, S. A. (2018). Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria. BIOORGANIC & MEDICINAL CHEMISTRY, 26(11), 2996-3005. doi:10.1016/j.bmc.2018.05.006
The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation
Capper, M. J., Wright, G. S. A., Barbieri, L., Luchinat, E., Mercatelli, E., McAlary, L., . . . Hasnain, S. S. (2018). The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation. NATURE COMMUNICATIONS, 9. doi:10.1038/s41467-018-04114-x
Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus
Stachulski, A. V., Santoro, M. G., Piacentini, S., Belardo, G., La Frazia, S., Pidathala, C., . . . Rossignol, J. -F. (2018). Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus. FUTURE MEDICINAL CHEMISTRY, 10(8), 851-862. doi:10.4155/fmc-2017-0217
X-ray and cryo-EM structures of inhibitor-bound cytochrome bc1 complexes for structure-based drug discovery
Amporndanai, K., Johnson, R. M., O'Neill, P., Fishwick, C. W. G., Jamson, A. H., Rawson, S., . . . Hasnain, S. (2018). X-ray and cryo-EM structures of inhibitor-bound cytochrome bc1 complexes for structure-based drug discovery. IUCrJ, 5(Pt 2), 200-210. doi:10.1107/S2052252518001616
2017
Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library
Johnston, K. L., Cook, D. A. N., Berry, N. G., Hong, W. D., Clare, R. H., Goddard, M., . . . Taylor, M. J. (2017). Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library. SCIENCE ADVANCES, 3(09). doi:10.1126/sciadv.aao1551
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
O'Neill, P. M., Amewu, R. K., Charman, S. A., Sabbani, S., Gnädig, N. F., Straimer, J., . . . Ward, S. A. (2017). A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance. Nature Communications, 8. doi:10.1038/ncomms15159
Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis.
Hong, W. D., Gibbons, P. D., Leung, S. C., Amewu, R., Stocks, P. A., Stachulski, A. V., . . . Nixon, G. L. (2017). Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis.. Journal of medicinal chemistry, 60(9), 3703-3726. doi:10.1021/acs.jmedchem.6b01718
2016
Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD
Price, K. E., Armstrong, C. M., Imlay, L. S., Hodge, D. M., Pidathala, C., Roberts, N. J., . . . Odom John, A. R. (2016). Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD. Scientific Reports, 6. doi:10.1038/srep36777
Corrigendum: Water-Assisted Nitrile Oxide Cycloadditions: Synthesis of Isoxazoles and Stereoselective Syntheses of Isoxazolines and 1,2,4-Oxadiazoles.
Kesornpun, C., Aree, T., Mahidol, C., Ruchirawat, S., & Kittakoop, P. (2016). Corrigendum: Water-Assisted Nitrile Oxide Cycloadditions: Synthesis of Isoxazoles and Stereoselective Syntheses of Isoxazolines and 1,2,4-Oxadiazoles.. Angewandte Chemie (International ed. in English), 55(36), 10548. doi:10.1002/anie.201607026
Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action
Fernandez-Alvaro, E., Hong, W. D., Nixon, G. L., O'Neil, P. M., & Calderon, F. (2016). Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action. JOURNAL OF MEDICINAL CHEMISTRY, 59(12), 5587-5603. doi:10.1021/acs.jmedchem.5b01485
A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile
Ismail, H. M., Barton, V. E., Panchana, M., Charoensutthivarakul, S., Biagini, G. A., Ward, S. A., & O'Neill, P. M. (2016). A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 55(22), 6401-6405. doi:10.1002/anie.201512062
A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.
Ismail, H. M., Barton, V. E., Panchana, M., Charoensutthivarakul, S., Biagini, G. A., Ward, S. A., & O'Neill, P. M. (2016). A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.. Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 128(22), 6511-6515. doi:10.1002/ange.201512062
Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites
Wong, M. H. L., Bryan, H. K., Copple, I. M., Jenkins, R. E., Chiu, P. H., Bibby, J., . . . Park, B. K. (2016). Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites. JOURNAL OF MEDICINAL CHEMISTRY, 59(6), 2396-2409. doi:10.1021/acs.jmedchem.5b01292
Small Molecule Inhibitors of Cyclophilin D To Protect Mitochondrial Function as a Potential Treatment for Acute Pancreatitis
Shore, E. R., Awais, M., Kershaw, N. M., Gibson, R. R., Pandalanen, S., Latawiec, D., . . . Sutton, R. (2016). Small Molecule Inhibitors of Cyclophilin D To Protect Mitochondrial Function as a Potential Treatment for Acute Pancreatitis. JOURNAL OF MEDICINAL CHEMISTRY, 59(06), 2596-2611. doi:10.1021/acs.jmedchem.5b01801
Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7
Ismail, H. M., Barton, V., Phanchana, M., Charoensutthivarakul, S., Wong, M. H. L., Hemingway, J., . . . Ward, S. A. (2016). Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(8), 2080-2085. doi:10.1073/pnas.1600459113
2015
Quinolone-Hydroxyquinoline Tautomerism in Quinolone 3-Esters. Preserving the 4-Oxoquinoline Structure To Retain Antimalarial Activity
Horta, P., Kus, N., Henriques, M. S. C., Paixao, J. A., Coelho, L., Nogueira, F., . . . Santos Cristiano, M. L. (2015). Quinolone-Hydroxyquinoline Tautomerism in Quinolone 3-Esters. Preserving the 4-Oxoquinoline Structure To Retain Antimalarial Activity. JOURNAL OF ORGANIC CHEMISTRY, 80(24), 12244-12257. doi:10.1021/acs.joc.5b02169
Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney
Shelton, L. M., Lister, A., Walsh, J., Jenkins, R. E., Wong, M. H. L., Rowe, C., . . . Copple, I. M. (2015). Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney. KIDNEY INTERNATIONAL, 88(06), 1261-1273. doi:10.1038/ki.2015.286
Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation
Naisbitt, D., Yang, E. L., Alhaidari, M., Berry, N., Lawrenson, A. S., Farrell, J., . . . Park, B. (2015). Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation. AIDS, 29(18), 2385-2395. doi:10.1097/QAD.0000000000000867
A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle
O'Neill, P. M., & Ward, S. A. (2015). A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54(46), 13504-13506. doi:10.1002/anie.201507264
Synthesis, structural and conformational analysis, and IR spectra of ethyl 4-chloro-7-iodoquinoline-3-carboxylate
Horta, P. C., Henriques, M. S. C., Kus, N., Paixao, J. A., O'Neill, P. M., Cristiano, M. L. S., & Fausto, R. (2015). Synthesis, structural and conformational analysis, and IR spectra of ethyl 4-chloro-7-iodoquinoline-3-carboxylate. TETRAHEDRON, 71(40), 7583-7592. doi:10.1016/j.tet.2015.07.076
Carbamoyl triazoles, Known Serine Protease Inhibitors, are a potent New Class of Antimalarial
O'Neill, P., McConville, M., Fernandez-molina, J., Angulo-Barturen, I., Bahamontes, N. R., Ballell-Pages, L., . . . Calderon, F. (2015). Carbamoyl triazoles, Known Serine Protease Inhibitors, are a potent New Class of Antimalarial. Journal of Medicinal Chemistry, 58(16), 6448-6455. doi:10.1021/acs.jmedchem.5b00434
From hybrid compounds to targeted drug delivery in antimalarial therapy
Oliveira, R., Miranda, D., Magalhaes, J., Capela, R., Perry, M. J., O'Neill, P. M., . . . Lopes, F. (2015). From hybrid compounds to targeted drug delivery in antimalarial therapy. BIOORGANIC & MEDICINAL CHEMISTRY, 23(16), 5120-5130. doi:10.1016/j.bmc.2015.04.017
2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties
Charoensutthivarakul, S., Hong, W. D., Leung, S. C., Gibbons, P. D., Bedingfield, P. T. P., Nixon, G. L., . . . O'Neill, P. M. (2015). 2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties. MEDCHEMCOMM, 6(7), 1252-1259. doi:10.1039/c5md00062a
<i>Plasmodium</i> IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target
Imlay, L. S., Armstrong, C. M., Masters, M. C., Li, T., Price, K. E., Edwards, R. L., . . . Odom, A. R. (2015). <i>Plasmodium</i> IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target. ACS INFECTIOUS DISEASES, 1(4), 157-167. doi:10.1021/id500047s
Inhibitors of the Plasmodium Mitochondrial Respiratory Chain
Nixon, G. L., Ward, S. A., O’Neill, P. M., & Biagini, G. A. (2014). Inhibitors of the Plasmodium Mitochondrial Respiratory Chain. In Encyclopedia of Malaria (pp. 1-18). Springer New York. doi:10.1007/978-1-4614-8757-9_15-1
Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1
Capper, M., O'Neill, P., Fisher, N., Strange, R., Moss, D., Ward, S., . . . Antonyuk, S. (2015). Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1. Proceedings of the National Academy of Sciences of the United States of America, 112(3), 755-760. doi:10.1073/pnas.1416611112
2014
Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications
Walsh, J., Jenkins, R. E., Wong, M., Olayanju, A., Powell, H., Copple, I., . . . Park, B. K. (2014). Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications. JOURNAL OF PROTEOMICS, 108, 171-187. doi:10.1016/j.jprot.2014.05.007
Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials.
Oliveira, R., Guedes, R. C., Meireles, P., Albuquerque, I. S., Gonçalves, L. M., Pires, E., . . . Lopes, F. (2014). Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials.. Journal of medicinal chemistry, 57(11), 4916-4923. doi:10.1021/jm5004528
Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities
Miranda, D., Capela, R., Albuquerque, I. S., Meireles, P., Paiva, I., Nogueira, F., . . . Lopes, F. (2014). Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities. ACS MEDICINAL CHEMISTRY LETTERS, 5(2), 108-112. doi:10.1021/ml4002985
4-bromopropofol decreases action potential generation in spinal neurons by inducing a glycine receptor-mediated tonic conductance
Eckle, V. S., Grasshoff, C., Mirakaj, V., O'Neill, P. M., Berry, N. G., Leuwer, M., & Antkowiak, B. (2014). 4-bromopropofol decreases action potential generation in spinal neurons by inducing a glycine receptor-mediated tonic conductance. BRITISH JOURNAL OF PHARMACOLOGY, 171(24), 5790-5801. doi:10.1111/bph.12880
Novel inhibitors of the Plasmodium falciparum electron transport chain
Stocks, P. A., Barton, V., Antoine, T., Biagini, G. A., Ward, S. A., & O'Neill, P. M. (2014). Novel inhibitors of the Plasmodium falciparum electron transport chain. PARASITOLOGY, 141(1), 50-65. doi:10.1017/S0031182013001571
Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential
Antoine, T., Fisher, N., Amewu, R., ONeill, P. M., Ward, S. A., & Biagini, G. A. (2014). Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 69(4), 1005-1016. doi:10.1093/jac/dkt486
2013
Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles.
Elliott, E. -C., Maggs, J. L., Park, B. K., O'Neill, P. M., & Stachulski, A. V. (2013). Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles.. Organic & biomolecular chemistry, 11(48), 8426-8434. doi:10.1039/c3ob41252k
Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions
Ismail, H. M., O'Neill, P. M., Hong, D. W., Finn, R. D., Henderson, C. J., Wright, A. T., . . . Paine, M. J. I. (2013). Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(49), 19766-19771. doi:10.1073/pnas.1320185110
Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers
Amewu, R. K., Chadwick, J., Hussain, A., Panda, S., Rinki, R., Janneh, O., . . . O'Neill, P. M. (2013). Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers. BIOORGANIC & MEDICINAL CHEMISTRY, 21(23), 7392-7397. doi:10.1016/j.bmc.2013.09.047
An Endoperoxide-Based Hybrid Approach to Deliver Falcipain Inhibitors Inside Malaria Parasites
Oliveira, R., Newton, A. S., Guedes, R. C., Miranda, D., Amewu, R. K., Srivastava, A., . . . Moreira, R. (2013). An Endoperoxide-Based Hybrid Approach to Deliver Falcipain Inhibitors Inside Malaria Parasites. CHEMMEDCHEM, 8(9), 1528-1536. doi:10.1002/cmdc.201300202
Targeting the mitochondrial electron transport chain of <i>Plasmodium falciparum</i>: new strategies towards the development of improved antimalarials for the elimination era
Nixon, G. L., Pidathala, C., Shone, A. E., Antoine, T., Fisher, N., O'Neill, P. M., . . . Biagini, G. A. (2013). Targeting the mitochondrial electron transport chain of <i>Plasmodium falciparum</i>: new strategies towards the development of improved antimalarials for the elimination era. FUTURE MEDICINAL CHEMISTRY, 5(13), 1573-1591. doi:10.4155/fmc.13.180
Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells
Bell, C. C., Castelazo, A. S., Yang, E. L., Maggs, J. L., Jeankins, R. E., Tugwood, J., . . . Park, B. K. (2013). Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells. CHEMICAL RESEARCH IN TOXICOLOGY, 26(7), 1064-1072. doi:10.1021/tx400041v
Antimalarial pharmacology and therapeutics of atovaquone
Nixon, G. L., Moss, D. M., Shone, A. E., Lalloo, D. G., Fisher, N., O'Neill, P. M., . . . Biagini, G. A. (2013). Antimalarial pharmacology and therapeutics of atovaquone. Journal of Antimicrobial Chemotherapy, 68(5), 977-985. doi:10.1093/jac/dks504
Antimalarial pharmacology and therapeutics of atovaquone
Nixon, G. L., Moss, D. M., Shone, A. E., Lalloo, D. G., Fisher, N., O'Neill, P. M., . . . Biagini, G. A. (2013). Antimalarial pharmacology and therapeutics of atovaquone. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 68(5), 977-985. doi:10.1093/jac/dks504
Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation
La Pensee, L., Sabbani, S., Sharma, R., Bhamra, I., Shore, E., Chadwick, A. E., . . . O'Neill, P. M. (2013). Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation. CHEMMEDCHEM, 8(5), 709-718. doi:10.1002/cmdc.201200536
Antitubercular pharmacodynamics of phenothiazines
Warman, A. J., Rito, T. S., Fisher, N. E., Moss, D. M., Berry, N. G., O'Neill, P. M., . . . Biagini, G. A. (2013). Antitubercular pharmacodynamics of phenothiazines. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 68(4), 869-880. doi:10.1093/jac/dks483
Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation
La Pensée, L., Sabbani, S., Sharma, R., Bhamra, I., Shore, E., Chadwick, A. E., . . . O'Neill, P. M. (2013). Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation. ChemMedChem, 8(5), 709-718.
X-ray Crystallography and Computational Docking for the Detection and Development of Protein-Ligand Interactions
Kershaw, N. M., Wright, G. S. A., Sharma, R., Antonyuk, S. V., Strange, R. W., Berry, N. G., . . . Hasnain, S. S. (2013). X-ray Crystallography and Computational Docking for the Detection and Development of Protein-Ligand Interactions. CURRENT MEDICINAL CHEMISTRY, 20(4), 569-575. Retrieved from https://www.webofscience.com/
2012
Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials
Copple, I. M., Mercer, A. E., Firman, J., Donegan, G., Herpers, B., Wong, M. H. L., . . . Park, B. K. (2012). Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials. MOLECULAR MEDICINE, 18(7), 1045-1055. doi:10.2119/molmed.2012.00154
HDQ, a Potent Inhibitor of <i>Plasmodium falciparum</i> Proliferation, Binds to the Quinone Reduction Site of the Cytochrome <i>bc</i><sub>1</sub> Complex
Vallieres, C., Fisher, N., Antoine, T., Al-Helal, M., Stocks, P., Berry, N. G., . . . Meunier, B. (2012). HDQ, a Potent Inhibitor of <i>Plasmodium falciparum</i> Proliferation, Binds to the Quinone Reduction Site of the Cytochrome <i>bc</i><sub>1</sub> Complex. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 56(7), 3739-3747. doi:10.1128/AAC.00486-12
Generation of quinolone antimalarials targeting the <i>Plasmodium falciparum</i> mitochondrial respiratory chain for the treatment and prophylaxis of malaria
Biagini, G. A., Fisher, N., Shone, A. E., Mubaraki, M. A., Srivastava, A., Hill, A., . . . Ward, S. A. (2012). Generation of quinolone antimalarials targeting the <i>Plasmodium falciparum</i> mitochondrial respiratory chain for the treatment and prophylaxis of malaria. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(21), 8298-8303. doi:10.1073/pnas.1205651109
Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods
Sharma, R., Lawrenson, A. S., Fisher, N. E., Warman, A. J., Shone, A. E., Hill, A., . . . Berry, N. G. (2012). Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods. JOURNAL OF MEDICINAL CHEMISTRY, 55(7), 3144-3154. doi:10.1021/jm3001482
The MEP pathway and the development of inhibitors as potential anti-infective agents
Hale, I., O'Neill, P. M., Berry, N. G., Odom, A., & Sharma, R. (2012). The MEP pathway and the development of inhibitors as potential anti-infective agents. MEDCHEMCOMM, 3(4), 418-433. doi:10.1039/c2md00298a
Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression.
Fisher, N., Abd Majid, R., Antoine, T., Al-Helal, M., Warman, A. J., Johnson, D. J., . . . Biagini, G. A. (2012). Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression.. The Journal of biological chemistry, 287(13), 9731-9741. doi:10.1074/jbc.m111.324319
Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2)
Pidathala, C., Amewu, R., Pacorel, B., Nixon, G. L., Gibbons, P., Hong, W. D., . . . O'Neill, P. M. (2012). Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2). JOURNAL OF MEDICINAL CHEMISTRY, 55(5), 1831-1843. doi:10.1021/jm201179h
Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2)
Leung, S. C., Gibbons, P., Amewu, R., Nixon, G. L., Pidathala, C., Hong, W. D., . . . O'Neill, P. M. (2012). Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2). JOURNAL OF MEDICINAL CHEMISTRY, 55(5), 1844-1857. doi:10.1021/jm201184h
Examination of the Cytotoxic and Embryotoxic Potential, and Underlying Mechanisms, of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials
Copple, I., Chadwick, A., Firman, J., Donegan, G., Herpers, B., Wong, M. H. L., . . . Park, K. (2012). Examination of the Cytotoxic and Embryotoxic Potential, and Underlying Mechanisms, of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials. Molecular Medicine, 18, 1045-1055.
Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain
Shone, A. E., Fisher, N., Mubaraki, M. A., Srivastava, A., Hill, A., Antoine, T., . . . Berry, N. (2012). Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain. Proceedings of the National Academy of Sciences of the United States of America, (109), 8298-8303.
HDQ, A Potent Inhibitor Of Plasmodium Falciparum Proliferation Binds To The Qi Site Of The Bc1 Complex
Vallières, C., Fisher, N., Antoine, T., Al-Helal, M., Stocks, P., Berry, N. G., . . . Meunier, B. (2012). HDQ, A Potent Inhibitor Of Plasmodium Falciparum Proliferation Binds To The Qi Site Of The Bc1 Complex. Antimicrobial Agents and Chemotherapy, 56, 3739-3747.
HDQ, a Potent Inhibitor of Plasmodium falciparum Proliferation, Binds to the Quinone Reduction Site of the Cytochrome bc(1) Complex
Vallieres,, C., Fisher,, N., Antoine,, T., Al-Helal,, M., Stocks,, P., Berry,, N. G., . . . Meunier,, B. (2012). HDQ, a Potent Inhibitor of Plasmodium falciparum Proliferation, Binds to the Quinone Reduction Site of the Cytochrome bc(1) Complex. Antimicrobial Agents and Chemotherapy, 56, 3739-3747.
The development of quinolone esters as novel antimalarial agents targeting the <i>Plasmodium falciparum bc</i><sub>1</sub> protein complex
Cowley, R., Leung, S., Fisher, N., Al-Helal, M., Berry, N. G., Lawrenson, A. S., . . . O'Neill, P. M. (2012). The development of quinolone esters as novel antimalarial agents targeting the <i>Plasmodium falciparum bc</i><sub>1</sub> protein complex. MEDCHEMCOMM, 3(1), 39-44. doi:10.1039/c1md00183c
2011
Convenient syntheses of benzo-fluorinated dibenz[b,f]azepines: rearrangements of isatins, acridines, and indoles.
Elliott, E. -C., Bowkett, E. R., Maggs, J. L., Bacsa, J., Park, B. K., Regan, S. L., . . . Stachulski, A. V. (2011). Convenient syntheses of benzo-fluorinated dibenz[b,f]azepines: rearrangements of isatins, acridines, and indoles.. Organic letters, 13(20), 5592-5595. doi:10.1021/ol202318w
Comparison of the Reactivity of Antimalarial 1,2,4,5-Tetraoxanes with 1,2,4-Trioxolanes in the Presence of Ferrous Iron Salts, Heme, and Ferrous Iron Salts/Phosphatidylcholine
Bousejra-El Garah, F., Wong, M. H. -L., Amewu, R. K., Muangnoicharoen, S., Maggs, J. L., Stigliani, J. -L., . . . O'Neill, P. M. (2011). Comparison of the Reactivity of Antimalarial 1,2,4,5-Tetraoxanes with 1,2,4-Trioxolanes in the Presence of Ferrous Iron Salts, Heme, and Ferrous Iron Salts/Phosphatidylcholine. JOURNAL OF MEDICINAL CHEMISTRY, 54(19), 6443-6455. doi:10.1021/jm200768h
Antimalarial Mannoxanes: Hybrid Antimalarial Drugs with Outstanding Oral Activity Profiles and A Potential Dual Mechanism of Action
Chadwick, J., Amewu, R. K., Marti, F., Bousejra-El Garah, F., Sharma, R., Berry, N. G., . . . O'Neill, P. M. (2011). Antimalarial Mannoxanes: Hybrid Antimalarial Drugs with Outstanding Oral Activity Profiles and A Potential Dual Mechanism of Action. CHEMMEDCHEM, 6(8), 1357-1361. doi:10.1002/cmdc.201100196
Cytochrome P450 6M2 from the malaria vector <i>Anopheles gambiae</i> metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed
Stevenson, B. J., Bibby, J., Pignatelli, P., Muangnoicharoen, S., O'Neill, P. M., Lian, L. -Y., . . . Paine, M. J. I. (2011). Cytochrome P450 6M2 from the malaria vector <i>Anopheles gambiae</i> metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed. INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 41(7), 492-502. doi:10.1016/j.ibmb.2011.02.003
Second generation analogues of RKA182: synthetic tetraoxanes with outstanding <i>in vitro</i> and <i>in vivo</i> antimalarial activities
Marti, F., Chadwick, J., Amewu, R. K., Burrell-Saward, H., Srivastava, A., Ward, S. A., . . . O'Neill, P. M. (2011). Second generation analogues of RKA182: synthetic tetraoxanes with outstanding <i>in vitro</i> and <i>in vivo</i> antimalarial activities. MEDCHEMCOMM, 2(7), 661-665. doi:10.1039/c1md00102g
The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials
Mercer, A. E., Copple, I. M., Maggs, J. L., O'Neill, P. M., & Park, B. K. (2011). The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(2), 987-996. doi:10.1074/jbc.M110.144188
Antimalarial Mannoxanes: Hybrid Antimalarial Drugs with Outstanding Oral Activity Profiles and A Potential Dual Mechanism of Action
Chadwick, J., Amewu, R. K., Marti, F., Bousejra-El Garah, F., Sharma, R., Berry, N. G., . . . O'Neill, P. M. (2011). Antimalarial Mannoxanes: Hybrid Antimalarial Drugs with Outstanding Oral Activity Profiles and A Potential Dual Mechanism of Action. Chemmedchem, 6, 1357-1361.
Convenient Syntheses of Benzo-Fluorinated Dibenz[b,f]azepines: Rearrangements of Isatins, Acridines, and Indoles
Elliott, E. C., Bowkett, E. R., Maggs, J. L., Bacsa, J., Park, B. K., Regan, S. L., . . . Stachulski, A. V. (2011). Convenient Syntheses of Benzo-Fluorinated Dibenz[b,f]azepines: Rearrangements of Isatins, Acridines, and Indoles. Organic Letters, 13, 5592-5595.
Identification of new antimalarial leads by use of virtual screening against cytochrome bc(1)
Rodrigues, T., Moreira, R., Gut, J., Rosenthal, P. J., O'Neill, P. M., Biagini, G. A., . . . Guedes, R. C. (2011). Identification of new antimalarial leads by use of virtual screening against cytochrome bc(1). Bioorganic & Medicinal Chemistry, 19, 6302-6308.
Second generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities
Marti,, F., Chadwick,, J., Amewu,, R. K., Burrell-Saward,, H., Srivastava,, A., Ward,, S. A., . . . O'Neill,, P. M. (2011). Second generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities. Medchemcomm, 2(661-66).
Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues
Berger, O., Kaniti, A., van Ba, C. T., Vial, H., Ward, S. A., Biagini, G. A., . . . O'Neill, P. M. (2011). Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues. Chemmedchem, 6, 2094-2108.
The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials
Mercer, A. E., Copple, I. M., Maggs, J. L., O'Neill, P. M., & Park, B. K. (2011). The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials. Journal of Biological Chemistry, 286, 987-996.
2010
Endoperoxide Carbonyl Falcipain 2/3 Inhibitor Hybrids: Toward Combination Chemotherapy of Malaria through a Single Chemical Entity
Gibbons, P., Verissimo, E., Araujo, N. C., Barton, V., Nixon, G. L., Amewu, R. K., . . . O'Neill, P. M. (2010). Endoperoxide Carbonyl Falcipain 2/3 Inhibitor Hybrids: Toward Combination Chemotherapy of Malaria through a Single Chemical Entity. JOURNAL OF MEDICINAL CHEMISTRY, 53(22), 8202-8206. doi:10.1021/jm1009567
Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins
O'Neill, P. M., Amewu, R. K., Nixon, G. L., ElGarah, F. B., Mungthin, M., Chadwick, J., . . . Ward, S. A. (2010). Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 49(33), 5693-5697. doi:10.1002/anie.201001026
A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of <i>Plasmodium falciparum</i>
Fisher, N., Hill, A., Mbekeani, A., Shone, A., Nixon, G., Stocks, P., . . . Biagini, G. A. (2010). A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of <i>Plasmodium falciparum</i>. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1797, 80. doi:10.1016/j.bbabio.2010.04.241
Rationale design of biotinylated antimalarial endoperoxide carbon centered radical prodrugs for applications in proteomics.
Barton, V., Ward, S. A., Chadwick, J., Hill, A., & O'Neill, P. M. (2010). Rationale design of biotinylated antimalarial endoperoxide carbon centered radical prodrugs for applications in proteomics.. Journal of medicinal chemistry, 53(11), 4555-4559. doi:10.1021/jm100201j
Synthesis, <i>in vitro</i> and <i>in vivo</i> antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared <i>via</i> thiol-olefin co-oxygenation (TOCO) of allylic alcohols
Amewu, R., Gibbons, P., Mukhtar, A., Stachulski, A. V., Ward, S. A., Hall, C., . . . O'Neill, P. M. (2010). Synthesis, <i>in vitro</i> and <i>in vivo</i> antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared <i>via</i> thiol-olefin co-oxygenation (TOCO) of allylic alcohols. ORGANIC & BIOMOLECULAR CHEMISTRY, 8(9), 2068-2077. doi:10.1039/b924319d
Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in <i>Plasmodium falciparum</i> and HL-60 cancer cell lines
Chadwick, J., Jones, M., Mercer, A. E., Stocks, P. A., Ward, S. A., Park, B. K., & O'Neill, P. M. (2010). Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in <i>Plasmodium falciparum</i> and HL-60 cancer cell lines. BIOORGANIC & MEDICINAL CHEMISTRY, 18(7), 2586-2597. doi:10.1016/j.bmc.2010.02.035
Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.
Pacorel, B., Leung, S. C., Stachulski, A. V., Davies, J., Vivas, L., Lander, H., . . . O'Neill, P. M. (2010). Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.. Journal of medicinal chemistry, 53(2), 633-640. doi:10.1021/jm901216v
Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives
Castrejon, J. L., Lavergne, S. N., El-Sheikh, A., Farrell, J., Maggs, J. L., Sabbani, S., . . . Naisbitt, D. J. (2010). Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives. CHEMICAL RESEARCH IN TOXICOLOGY, 23(1), 184-192. doi:10.1021/tx900329b
A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of Plasmodium falciparum
Fisher, N., Hill, A., Mbekeani, A., Shone, A., Nixon, G., Stocks, P., . . . Biagini, G. A. (2010). A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of Plasmodium falciparum. Biochimica Et Biophysica Acta-Bioenergetics, 1797, 80.
Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH:quinone oxidoreductase
Biagini, G. A., Hill, A., Mbekeani, A., Shone, A., Nixon, G., Stocks, P., . . . Ward, S. A. (2010). Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH:quinone oxidoreductase. Malaria journal, 9(Suppl 2), O4. doi:10.1186/1475-2875-9-s2-o4
Diastereoselective schenck ene reaction of singlet oxygen with chiral allylic alcohols; access to enantiomerically enriched 1,2,4-trioxanes
Sabbani, S., La Pensee, L., Bacsa, J., Hedenstrom, E., & O'Neill, P. M. (2010). Diastereoselective schenck ene reaction of singlet oxygen with chiral allylic alcohols; access to enantiomerically enriched 1,2,4-trioxanes. Tetrahedron, 65, 8531-8537.
Inhibiting Plasmodium cytochrome bc(1): a complex issue
Barton, V., Fisher, N., Biagini, G. A., Ward, S. A., & O'Neill, P. M. (2010). Inhibiting Plasmodium cytochrome bc(1): a complex issue. Current Opinion in Chemical Biology, 14, 440-446.
Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates
Araujo, N. C. P., Barton, V., Jones, M., Stocks, P. A., Ward, S. A., Davies, J., . . . O'Neill, P. M. (2010). Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates. Bioorganic & Medicinal Chemistry Letters, 19, 2038.
Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols
Amewu, R., Gibbons, P., Mukhtar, A., Stachulski, A. V., Ward, S. A., Hall, C., . . . O'Neill, P. M. (2010). Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols. Organic & Biomolecular Chemistry, 8, 2068-2077.
The Molecular Mechanism of Action of Artemisinin-The Debate Continues
O'Neill, P. M., Barton, V. E., & Ward, S. A. (2010). The Molecular Mechanism of Action of Artemisinin-The Debate Continues. Molecules, 15, 1705-1721.
The type II NADH: Quinone oxidoreductase of Mycobacterium tuberculosis: A novel drug target for an age-old problem
Warman, A. J., Rito, T., Fisher, N., Berry, N. G., O'Neill, P. M., Ward, S. A., & Biagini, G. A. (2010). The type II NADH: Quinone oxidoreductase of Mycobacterium tuberculosis: A novel drug target for an age-old problem. Biochimica Et Biophysica Acta-Bioenergetics, 1797, 117-118.
2009
Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4′-Fluoro and 4′-Chloro Analogues of Amodiaquine. Identification of a Suitable "Back-Up" Compound for <i>N-tert</i>-Butyl Isoquine
O'Neill, P. M., Shone, A. E., Stanford, D., Nixon, G., Asadollahy, E., Park, B. K., . . . Ward, S. A. (2009). Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4′-Fluoro and 4′-Chloro Analogues of Amodiaquine. Identification of a Suitable "Back-Up" Compound for <i>N-tert</i>-Butyl Isoquine. JOURNAL OF MEDICINAL CHEMISTRY, 52(7), 1828-1844. doi:10.1021/jm8012757
Antitumour and antimalarial activity of artemisinin-acridine hybrids
Jones, M., Mercer, A. E., Stocks, P. A., La Pensee, L. J. I., Cosstick, R., Park, B. K., . . . O'Neill, P. M. (2009). Antitumour and antimalarial activity of artemisinin-acridine hybrids. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(7), 2033-2037. doi:10.1016/j.bmcl.2009.02.028
Antitumour and antimalarial activity of artemisinin–acridine hybrids
Jones, M., Mercer, A. E., Stocks, P. A., La Pensée, L. J. I., Cosstick, R., Park, B. K., . . . O’Neill, P. M. (2009). Antitumour and antimalarial activity of artemisinin–acridine hybrids. Bioorganic & Medicinal Chemistry Letters, 19(7), 2033-2037. doi:10.1016/j.bmcl.2009.02.028
Candidate Selection and Preclinical Evaluation of <i>N</i>-<i>tert</i>-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century
O'Neill, P. M., Park, B. K., Shone, A. E., Maggs, J. L., Roberts, P., Stocks, P. A., . . . Ward, S. A. (2009). Candidate Selection and Preclinical Evaluation of <i>N</i>-<i>tert</i>-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century. JOURNAL OF MEDICINAL CHEMISTRY, 52(5), 1408-1415. doi:10.1021/jm8012618
Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against <i>P-falciparum</i> malaria parasites and HL-60 cancer cells
Chadwick, J., Mercer, A. E., Park, B. K., Cosstick, R., & O'Neill, P. M. (2009). Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against <i>P-falciparum</i> malaria parasites and HL-60 cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY, 17(3), 1325-1338. doi:10.1016/j.bmc.2008.12.017
Antitumour and antimalarial activity of artemisinin-acridine hybrids
Jones, M., Mercer, A. E., Stocks, P. A., La Pensee, L. J., Cosstick, R., Park, B. K., . . . O'Neill, P. M. (2009). Antitumour and antimalarial activity of artemisinin-acridine hybrids. Bioorganic & Medicinal Chemistry Letters, 19, 2033-2037.
Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials.
Davis, C. B., Bambal, R., Moorthy, G. S., Hugger, E., Xiang, H., Park, B. K., . . . Ward, S. A. (2009). Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials.. Journal of pharmaceutical sciences, 98(1), 362-377. doi:10.1002/jps.21469
Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P-falciparum malaria parasites and HL-60 cancer cells
Chadwick, J., Mercer, A. E., Park, B. K., Cosstick, R., & O'Neill, P. M. (2009). Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P-falciparum malaria parasites and HL-60 cancer cells. Bioorganic & Medicinal Chemistry, 17, 1325-1338.
2008
Piperidine dispiro-1,2,4-trioxane analogues
Sabbani, S., Stocks, P. A., Ellis, G. L., Davies, J., Hedenstrom, E., Ward, S. A., & O'Neill, P. M. (2008). Piperidine dispiro-1,2,4-trioxane analogues. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(21), 5804-5808. doi:10.1016/j.bmcl.2008.09.052
Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors
Verissimo, E., Berry, N., Gibbons, P., Cristiano, M. L. S., Rosenthal, P. J., Gut, J., . . . O'Neill, P. M. (2008). Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(14), 4210-4214. doi:10.1016/j.bmcl.2008.05.068
Stimulation of nitroso sulfamethoxazole-specific T-cells with structurally-related hydroxylamine and nitroso metabolites
Castrejon, J. L., Farrell, J., O'neill, P. M., Park, B. K., & Naisbitt, D. J. (2008). Stimulation of nitroso sulfamethoxazole-specific T-cells with structurally-related hydroxylamine and nitroso metabolites. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 65(6), 997. Retrieved from https://www.webofscience.com/
Acridinediones:: Selective and potent inhibitors of the malaria parasite mitochondrial <i>bc</i><sub>1</sub> complex
Biagini, G. A., Fisher, N., Berry, N., Stocks, P. A., Meunier, B., Williams, D. P., . . . Ward, S. A. (2008). Acridinediones:: Selective and potent inhibitors of the malaria parasite mitochondrial <i>bc</i><sub>1</sub> complex. MOLECULAR PHARMACOLOGY, 73(5), 1347-1355. doi:10.1124/mol.108.045120
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles
Ellis, G. L., Amewu, R., Sabbani, S., Stocks, P. A., Shone, A., Stanford, D., . . . O'Neill, P. M. (2008). Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles. JOURNAL OF MEDICINAL CHEMISTRY, 51(7), 2170-2177. doi:10.1021/jm701435h
An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity
Ellis, G. L., Amewu, R., Hall, C., Rimmer, K., Ward, S. A., & O’Neill, P. M. (2008). An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity. Bioorganic & Medicinal Chemistry Letters, 18(5), 1720-1724. doi:10.1016/j.bmcl.2008.01.053
An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity
Ellis, G. L., Amewu, R., Hall, C., Rimmer, K., Ward, S. A., & O'Neill, P. M. (2008). An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(5), 1720-1724. doi:10.1016/j.bmcl.2008.01.053
Piperidine dispiro-1,2,4-trioxane analogues
Sabbani, S., Stocks, P. A., Ellis, G. L., Davies, J., Hedenstrom, E., Ward, S. A., & O'Neill, P. M. (2008). Piperidine dispiro-1,2,4-trioxane analogues. Bioorganic & Medicinal Chemistry Letters, 18, 5804-5808.
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles
Ellis, G. L., Amewu, R., Sabbani, S., Stocks, P. A., Shone, A., Stanford, D., . . . O'Neill, P. M. (2008). Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles. Journal of Medicinal Chemistry, 51, 2170-2177.
2007
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs
Stocks, P. A., Bray, P. G., Barton, V. E., Al-Helal, M., Jones, M., Araujo, N. C., . . . O'Neill, P. M. (2007). Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 46(33), 6278-6283. doi:10.1002/anie.200604697
Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds
Mercer, A. E., Maggs, J. L., Sun, X. -M., Cohen, G. M., Chadwick, J., O'Neill, P. M., & Park, B. K. (2007). Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds. JOURNAL OF BIOLOGICAL CHEMISTRY, 282(13), 9372-9382. doi:10.1074/jbc.M610375200
Back matter
Back matter (2007). Organic & Biomolecular Chemistry, 5(4), 708. doi:10.1039/b701157c
Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs
Stocks, P. A., Bray, P. G., Barton, V., Al-Helal, M., Jones, M., Araujo, N. C., . . . O'Neill, P. (2007). Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs. Angewandte Chemie International Edition, 46(33), 6278-6283. doi:10.1002/anie.200604697
2006
Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin
Amewu, R., Stachulski, A. V., Ward, S. A., Berry, N. G., Bray, P. G., Davies, J., . . . O'Neill, P. M. (2006). Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin. ORGANIC & BIOMOLECULAR CHEMISTRY, 4(24), 4431-4436. doi:10.1039/b613565j
Anticancer activity of artemisinin-derived trioxanes
Posner, G. H., D'Angelo, J., O'Neill, P. M., & Mercer, A. (2006). Anticancer activity of artemisinin-derived trioxanes. EXPERT OPINION ON THERAPEUTIC PATENTS, 16(12), 1665-1672. doi:10.1517/13543776.16.12.1665
Synthesis of 1,2,4-trioxepanes via application of thiol-olefin Co-oxygenation methodology
Amewu, R., Stachulski, A. V., Berry, N. G., Ward, S. A., Davies, J., Labat, G., . . . O'Neill, P. M. (2006). Synthesis of 1,2,4-trioxepanes via application of thiol-olefin Co-oxygenation methodology. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(23), 6124-6130. doi:10.1016/j.bmcl.2006.08.098
PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.
Bray, P. G., Mungthin, M., Hastings, I. M., Biagini, G. A., Saidu, D. K., Lakshmanan, V., . . . Ward, S. A. (2006). PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.. Molecular microbiology, 62(1), 238-251. doi:10.1111/j.1365-2958.2006.05368.x
Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria.
Biagini, G. A., Viriyavejakul, P., O'neill, P. M., Bray, P. G., & Ward, S. A. (2006). Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria.. Antimicrobial agents and chemotherapy, 50(5), 1841-1851. doi:10.1128/aac.50.5.1841-1851.2006
A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs
O'Neill, P. M., Ward, S. A., Berry, N. G., Jeyadevan, J. P., Biagini, G. A., Asadollaly, E., . . . Bray, P. G. (2006). A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs. CURRENT TOPICS IN MEDICINAL CHEMISTRY, 6(5), 479-507. doi:10.2174/156802606776743147
Lewis acid catalysed rearrangements of unsaturated bicyclic [2.2.n] endoperoxides in the presence of vinyl silanes; access to novel Fenozan BO-7 analogues
O'Neill, P. M., Rawe, S. L., Storr, R. C., Ward, S. A., & Posner, G. H. (2006). Lewis acid catalysed rearrangements of unsaturated bicyclic [2.2.n] endoperoxides in the presence of vinyl silanes; access to novel Fenozan BO-7 analogues. Tetrahedron Letters, 46, 3029-3032.
2005
Current development portfolio for antimalarial therapies
Biagini, G. A., O'Neill, P. M., & Bray, P. G. (2005). Current development portfolio for antimalarial therapies. Current Opinion in Pharmacology, 5, 473-478.
Enantiomeric 1,2,4-Trioxanes Display Equivalent In Vitro Antimalarial Activity Versus Plasmodium falciparum Malaria Parasites: Implications for the Molecular Mechanism of Action of the Artemisinins
O'Neill, P. M., Rawe, S. L., Borstnik, K., Miller, A., Storr, R. C., Ward, S. A., . . . Posner, G. H. (2005). Enantiomeric 1,2,4-Trioxanes Display Equivalent In Vitro Antimalarial Activity Versus Plasmodium falciparum Malaria Parasites: Implications for the Molecular Mechanism of Action of the Artemisinins. ChemBiochem, 6, 2048-2054.
Quinolines and artemisinin: Chemistry, biology and history
Bray, P. G., Ward, S. A., & O'Neill, P. M. (2005). Quinolines and artemisinin: Chemistry, biology and history. CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, 295, 3-38.
The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents
O'Neill, P. M. (2005). The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents. Expert Opinion On Investigational Drugs, 14(9), 1117-1128.
2004
Design and synthesis of endoperoxide antimalarial prodrug models.
O'Neill, P. M., Stocks, P. A., Pugh, M. D., Araujo, N. C., Korshin, E. E., Bickley, J. F., . . . Bachi, M. D. (2004). Design and synthesis of endoperoxide antimalarial prodrug models.. Angewandte Chemie (International ed. in English), 43(32), 4193-4197. doi:10.1002/anie.200453859
Hepatocellular bioactivation and cytotoxicity of the synthetic endoperoxide antimalarial arteflene.
Maggs, J. L., Bishop, L. P. D., Batty, K. T., Dodd, C. C., Ilett, K. F., O'Neill, P. M., . . . Kevin Park, B. (2004). Hepatocellular bioactivation and cytotoxicity of the synthetic endoperoxide antimalarial arteflene.. Chemico-biological interactions, 147(2), 173-184. doi:10.1016/j.cbi.2003.12.005
Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10β-(2-hydroxyethyl)deoxoartemisinin
Jeyadevan, J. P., Bray, P. G., Chadwick, J., Mercer, A. E., Byrne, A., Ward, S. A., . . . O'Neill, P. M. (2004). Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10β-(2-hydroxyethyl)deoxoartemisinin. JOURNAL OF MEDICINAL CHEMISTRY, 47(5), 1290-1298. doi:10.1021/jm030974c
Antimalarial and Antitumor Evaluation of Novel C-10 Non-Acetal Dimers of 10β-(2-Hydroxyethyl)deoxoartemisinin
Jeyadevan, J. P., Bray, P. G., Chadwick, J., Mercer, A. E., Byrne, A., Ward, S. A., . . . O'Neill, P. M. (2004). Antimalarial and Antitumor Evaluation of Novel C-10 Non-Acetal Dimers of 10β-(2-Hydroxyethyl)deoxoartemisinin. Journal of Medicinal Chemistry, 47(5), 1290-1298. doi:10.1021/jm030974c
A medicinal chemistry perspective on artemisinin and related endoperoxides
O'Neill, P. M., & Posner, G. H. (2004). A medicinal chemistry perspective on artemisinin and related endoperoxides. Journal Of Medicinal Chemistry, 47(12), 2945-2964.
Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore
O'Neill, P. M., Mukhtar, A., Ward, S. A., Bickley, J. F., Davies, J., Bachi, M. D., & Stocks, P. A. (2004). Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore. Organic Letters, 6(18), 3035-3038.
Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial chugs
Biagini, G. A., Pasini, E. M., Hughes, R., De Koning, H. P., Vial, H. J., O'Neill, P. M., . . . Bray, P. G. (2004). Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial chugs. Blood, 104(10), 3372-3377.
Knowledge of the proposed chemical mechanism of action and cytochrome P450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides
Posner, G. H., & O'Neill, P. M. (2004). Knowledge of the proposed chemical mechanism of action and cytochrome P450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides. Accounts Of Chemical Research, 37(6), 397-404.
Medicinal chemistry - A worthy adversary for malaria
O'Neill, P. M. (2004). Medicinal chemistry - A worthy adversary for malaria. Nature, 430(7002), 838-839.
T-cell recognition of carbamazepine and carbamazepine metabolites
Naisbitt, D. J., Wu, Y., Farrell, J., O'Neill, P. M., Pirmohamed, M., & Park, B. K. (2004). T-cell recognition of carbamazepine and carbamazepine metabolites. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 57(5), 669. Retrieved from https://www.webofscience.com/
2003
Isoquine and related amodiaquine analogues: A new generation of improved 4-aminoquinoline antimalarials
O'Neill, P. M., Mukhtar, A., Stocks, P. A., Randle, L. E., Hindley, S., Ward, S. A., . . . Park, B. K. (2003). Isoquine and related amodiaquine analogues: A new generation of improved 4-aminoquinoline antimalarials. JOURNAL OF MEDICINAL CHEMISTRY, 46(23), 4933-4945. doi:10.1021/jm030796n
Antimalarial chemotherapy: young guns or back to the future?
Biagini, G. A., O'Neill, P. M., Nzila, A., Ward, S. A., & Bray, P. G. (2003). Antimalarial chemotherapy: young guns or back to the future?. Trends in parasitology, 19(11), 479-487. doi:10.1016/j.pt.2003.09.011
Artemisinins target the SERCA of Plasmodium falciparum.
Eckstein-Ludwig, U., Webb, R. J., Van Goethem, I. D. A., East, J. M., Lee, A. G., Kimura, M., . . . Krishna, S. (2003). Artemisinins target the SERCA of Plasmodium falciparum.. Nature, 424(6951), 957-961. doi:10.1038/nature01813
Co(thd)(2): a superior catalyst for aerobic epoxidation and hydroperoxysilylation of unactivated alkenes: application to the synthesis of spiro-1,2,4-trioxanes
O'Neill, P. M., Hindley, S., Pugh, M. D., Davies, J., Bray, P. G., Park, B. K., . . . Stocks, P. A. (2003). Co(thd)(2): a superior catalyst for aerobic epoxidation and hydroperoxysilylation of unactivated alkenes: application to the synthesis of spiro-1,2,4-trioxanes. Tetrahedron Letters, 44(44), 8135-8138.
2002
Anti-malarial compounds
Ward, S. A., O'Neill, P. M., & Park, B. K. (2002). Anti-malarial compounds.
Mechanism-based design of parasite-targeted artemisinin derivatives: Synthesis and antimalarial activity of new diamine containing analogues
Hindley, S., Ward, S. A., Storr, R. C., Searle, N. L., Bray, P. G., Park, B. K., . . . O'Neill, P. M. (2002). Mechanism-based design of parasite-targeted artemisinin derivatives: Synthesis and antimalarial activity of new diamine containing analogues. Journal Of Medicinal Chemistry, 45(5), 1052-1063.
Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum
Stocks, P. A., Raynes, K. J., Bray, P. G., Park, B. K., O'Neill, P. M., & Ward, S. A. (2002). Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum. Journal Of Medicinal Chemistry, 45(23), 4975-4983.
2001
Erratum: Optimisation of the allylsilane approach to C-10 deoxo carba analogues of dihydroartemisinin - Synthesis and in vitro antimalarial activity of new, metabolically stable C-10 analogues (Journal of the Chemical Society. Perkin Transactions 1 (2001) (2682))
O'Neill, P. M., Pugh, M., Stachulski, A. V., Ward, S. A., Davies, J., & Park, B. K. (2001). Erratum: Optimisation of the allylsilane approach to C-10 deoxo carba analogues of dihydroartemisinin - Synthesis and in vitro antimalarial activity of new, metabolically stable C-10 analogues (Journal of the Chemical Society. Perkin Transactions 1 (2001) (2682)). Journal of the Chemical Society. Perkin Transactions 1, (23), 3214.
Optimisation of the allylsilane approach to C-10 deoxo carba analogues of dihydroartemisinin: synthesis and in vitro antimalarial activity of new, metabolically stable C-10 analogues
O'Neill, P. M., Pugh, M., Stachulski, A. V., Ward, S. A., Davies, J., & Park, B. K. (2001). Optimisation of the allylsilane approach to C-10 deoxo carba analogues of dihydroartemisinin: synthesis and in vitro antimalarial activity of new, metabolically stable C-10 analogues. Journal of the Chemical Society, Perkin Transactions 1, (20), 2682-2689. doi:10.1039/b104340b
Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite.
O'Neill, P. M., Scheinmann, F., Stachulski, A. V., Maggs, J. L., & Park, B. K. (2001). Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite.. Journal of medicinal chemistry, 44(9), 1467-1470. doi:10.1021/jm001061a
Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin.
O'Neill, P. M., Miller, A., Bishop, L. P., Hindley, S., Maggs, J. L., Ward, S. A., . . . Park, B. K. (2001). Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin.. Journal of medicinal chemistry, 44(1), 58-68. doi:10.1021/jm000987f
Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite
O'Neill, P. M., Scheinmann, F., Stachulski, A. V., Maggs, J. L., & Park, B. K. (2001). Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite. Journal Of Medicinal Chemistry, 44(9), 1467-1470.
Meta
Park, B. K., Kitteringham, N. R., & O'Neill, P. M. (2001). Meta. Annual Review Of Pharmacology And Toxicology, 41, 443-470.
Regioselective Mukaiyama hydroperoxysilylation of 2-alkyl- or 2-aryl-prop-2-en-1-ols: application to a new synthesis of 1,2,4-trioxanes
O'Neill, P. M., Pugh, M., Davies, J., Ward, S. A., & Park, B. K. (2001). Regioselective Mukaiyama hydroperoxysilylation of 2-alkyl- or 2-aryl-prop-2-en-1-ols: application to a new synthesis of 1,2,4-trioxanes. Tetrahedron Letters, 42(27), 4569-4571.
2000
4-Aminoquinolines as antimalarials
Raynes, K. J., Ward, S. A., O'Neill, P. M., Stocks, P., & Park, B. K. (2000). 4-Aminoquinolines as antimalarials.
Biliary metabolites of beta-artemether in rats: Biotransformations of an antimalarial endoperoxide
Maggs, J. L., Bishop, L. P. D., Edwards, G., O'Neill, P. M., Ward, S. A., Winstanley, P. A., & Park, B. K. (2000). Biliary metabolites of beta-artemether in rats: Biotransformations of an antimalarial endoperoxide. Drug Metabolism And Disposition, 28(2), 209-217.
Biomimetic Fe(II)-mediated degradation of arteflene (Ro-42-1611). The first EPR spin-trapping evidence for the previously postulated secondary carbon-centered cyclohexyl radical
O'Neill, P. M., Bishop, L. P. D., Searle, N. L., Maggs, J. L., Storr, R. C., Ward, S. A., . . . Mabbs, F. (2000). Biomimetic Fe(II)-mediated degradation of arteflene (Ro-42-1611). The first EPR spin-trapping evidence for the previously postulated secondary carbon-centered cyclohexyl radical. Journal Of Organic Chemistry, 65(5), 1578-1582.
1999
Application of the TMSOTfAgClO4 activator system to the synthesis of novel, potent, C-10 phenoxy derivatives of dihydroartemisinin
O'Neill, P. M., Miller, A., Ward, S. A., Park, B. K., Scheinmann, F., & Stachulski, A. V. (1999). Application of the TMSOTfAgClO4 activator system to the synthesis of novel, potent, C-10 phenoxy derivatives of dihydroartemisinin. Tetrahedron Letters, 40(51), 9129-9132. doi:10.1016/s0040-4039(99)01891-2
Asymmetric syntheses of enantiomeric 3-p-fluorophenyl 1,2,4-trioxane analogues of the antimalarial artemisinin
O'Neill, P. M., Miller, A., Bickley, J. F., Scheinmann, F., Chang, H. O., & Posner, G. H. (1999). Asymmetric syntheses of enantiomeric 3-p-fluorophenyl 1,2,4-trioxane analogues of the antimalarial artemisinin. Tetrahedron Letters, 40(51), 9133-9136.
Metabolism of the antimalarial endoperoxide Ro 42-1611 (arteflene) in the rat: Evidence for endoperoxide bioactivation
Bishop, L. P. D., Maggs, J. L., O'Neill, P. M., & Park, B. K. (1999). Metabolism of the antimalarial endoperoxide Ro 42-1611 (arteflene) in the rat: Evidence for endoperoxide bioactivation. Journal Of Pharmacology And Experimental Therapeutics, 289(1), 511-520.
New 4-aminoquinoline mannich base antimalarials. 1. Effect of an alkyl substituent in the 5 '-position of the 4 '-hydroxyanilino side chain
Raynes, K. J., Stocks, P. A., O'Neill, P. M., Park, B. K., & Ward, S. A. (1999). New 4-aminoquinoline mannich base antimalarials. 1. Effect of an alkyl substituent in the 5 '-position of the 4 '-hydroxyanilino side chain. Journal Of Medicinal Chemistry, 42(15), 2747-2751.
Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether
O'Neill, P. M., Searle, N. L., Kan, K. W., Storr, R. C., Maggs, J. L., Ward, S. A., . . . Park, B. K. (1999). Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether. Journal Of Medicinal Chemistry, 42(26), 5487-5493.
1998
Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs
Naisbitt, D. J., Williams, D. P., O'Neill, P. M., Maggs, J. L., Willock, D. J., Pirmohamed, M., & Park, B. K. (1998). Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs. CHEMICAL RESEARCH IN TOXICOLOGY, 11(12), 1586-1595. doi:10.1021/tx980148k
Safety assessment of peroxide antimalarials: clinical and chemical perspectives
Park, B. K., O'Neill, P. M., Maggs, J. L., & Pirmohamed, M. (1998). Safety assessment of peroxide antimalarials: clinical and chemical perspectives. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 46(6), 521-529. doi:10.1046/j.1365-2125.1998.00838.x
4-aminoquinolines - Past, present, and future: A chemical perspective
O'Neill, P. M., Bray, P. G., Hawley, S. R., Ward, S. A., & Park, B. K. (1998). 4-aminoquinolines - Past, present, and future: A chemical perspective. Pharmacology & Therapeutics, 77(1), 29-58.
A carbonyl oxide route to antimalarial yingzhaosu A analogues: Synthesis and antimalarial activity
O'Neill, P. M., Searle, N. L., Raynes, K. J., Maggs, J. L., Ward, S. A., Storr, R. C., . . . Posner, G. H. (1998). A carbonyl oxide route to antimalarial yingzhaosu A analogues: Synthesis and antimalarial activity. Tetrahedron Letters, 39(33), 6065-6068.
Effect of disposition of Mannich antimalarial agents on their pharmacology and toxicology
Ruscoe, J. E., Tingle, M. D., O'Neill, P. M., Ward, S. A., & Park, B. K. (1998). Effect of disposition of Mannich antimalarial agents on their pharmacology and toxicology. Antimicrobial Agents And Chemotherapy, 42(9), 2410-2416.
Relationship between antimalarial drug activity, accumulation, and inhibition of heme polymerization in Plasmodium falciparum in vitro
Hawley, S. R., Bray, P. G., Mungthin, M., Atkinson, J. D., O'Neill, P. M., & Ward, S. A. (1998). Relationship between antimalarial drug activity, accumulation, and inhibition of heme polymerization in Plasmodium falciparum in vitro. Antimicrobial Agents And Chemotherapy, 42(3), 682-686.
Synthesis of the 8-aminoquinoline antimalarial 5-fluoroprimaquine
O'Neill, P. M., Storr, R. C., & Park, B. K. (1998). Synthesis of the 8-aminoquinoline antimalarial 5-fluoroprimaquine. Tetrahedron, 54(18), 4615-4622.
The biliary metabolites of beta-artemether, an endoperoxide antimalarial
Bell, J. O., Edwards, G., Maggs, J. L., Bishop, L. P., O'Neill, P. M., Ward, S. A., . . . Park, B. K. (1998). The biliary metabolites of beta-artemether, an endoperoxide antimalarial. British Journal Of Pharmacology, 124.
1997
The rat biliary metabolites of dihydroartemisinin, an antimalarial endoperoxide
Maggs, J. L., Madden, S., Bishop, L. P., ONeill, P. M., & Park, B. K. (1997). The rat biliary metabolites of dihydroartemisinin, an antimalarial endoperoxide. Drug Metabolism and Disposition, 25(10), 1200-1204.
The biomimetic iron-mediated degradation of arteflene (Ro-42-1611),an endoperoxide antimalarial: Implications for the mechanism of antimalarial activity
O'Neill, P. M., Bishop, L. P., Searle, N. L., Maggs, J. L., Ward, S. A., Bray, P. G., . . . Kevin Park, B. (1997). The biomimetic iron-mediated degradation of arteflene (Ro-42-1611),an endoperoxide antimalarial: Implications for the mechanism of antimalarial activity. Tetrahedron Letters, 38(24), 4263-4266. doi:10.1016/s0040-4039(97)00874-5
Disposition of amodiaquine and related antimalarial agents in human neutrophils: Implications for drug design
Naisbitt, D. J., Ruscoe, J. E., Williams, D., ONeill, P. M., Pirmohamed, M., & Park, B. K. (1997). Disposition of amodiaquine and related antimalarial agents in human neutrophils: Implications for drug design. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 280(2), 884-893. Retrieved from https://www.webofscience.com/
Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues.
O'Neill, P. M., Willock, D. J., Hawley, S. R., Bray, P. G., Storr, R. C., Ward, S. A., & Park, B. K. (1997). Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues.. Journal of medicinal chemistry, 40(4), 437-448. doi:10.1021/jm960370r
1996
Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of benzylamino and alkylamino ether analogues of artemisinin.
O'Neill, P. M., Bishop, L. P., Storr, R. C., Hawley, S. R., Maggs, J. L., Ward, S. A., & Park, B. K. (1996). Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of benzylamino and alkylamino ether analogues of artemisinin.. Journal of medicinal chemistry, 39(22), 4511-4514. doi:10.1021/jm9604944
The role of drug accumulation in 4-aminoquinoline antimalarial potency - The influence of structural substitution and physicochemical properties
Hawley, S. R., Bray, P. G., ONeill, P. M., Park, B. K., & Ward, S. A. (1996). The role of drug accumulation in 4-aminoquinoline antimalarial potency - The influence of structural substitution and physicochemical properties. Biochemical Pharmacology, 52(5), 723-733.
Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity.
Naisbitt, D. J., ONeill, P. M., Pirmohamed, M., & Park, B. K. (1996). Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 6(13), 1511-1516. doi:10.1016/S0960-894X(96)00260-0
The effect of fluorine substitution on the antimalarial activity of tebuquine
ONeill, P. M., Hawley, S. R., Storr, R. C., Ward, S. A., & Park, B. K. (1996). The effect of fluorine substitution on the antimalarial activity of tebuquine. Bioorganic and Medicinal Chemistry Letters, 6(4), 391-392.
Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component
Hawley, S. R., Bray, P. G., ONeill, P. M., Naisbitt, D. J., Park, B. K., & Ward, S. A. (1996). Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 40(10), 2345-2349. doi:10.1128/AAC.40.10.2345
1995
THE EFFECT OF FLUORINE SUBSTITUTION ON THE HAEMOTOXICITY OF PRIMAQUINE
ONEILL, P. M., TINGLE, M. D., MAHMUD, R., STORR, R. C., WARD, S. A., & PARK, B. K. (1995). THE EFFECT OF FLUORINE SUBSTITUTION ON THE HAEMOTOXICITY OF PRIMAQUINE. Bioorganic and Medicinal Chemistry Letters, 5(20), 2309-2314.
The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: chemical mechanisms and the effects of fluorine substitution.
Tingle, M. D., Jewell, H., Maggs, J. L., O'Neill, P. M., & Park, B. K. (1995). The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: chemical mechanisms and the effects of fluorine substitution.. Biochemical pharmacology, 50(7), 1113-1119. doi:10.1016/0006-2952(95)00236-s
Quinoline Analogues of Ortho-Quinodimethane
White, L. (1995). Quinoline Analogues of Ortho-Quinodimethane. Tetrahedron Letters, 36(33), 5983-5986. doi:10.1016/00404-0399(50)1159f-
THE EFFECT OF CHEMICAL SUBSTITUTION ON THE METABOLIC-ACTIVATION, METABOLIC DETOXICATION, AND PHARMACOLOGICAL ACTIVITY OF AMODIAQUINE IN THE MOUSE
RUSCOE, J. E., JEWELL, H., MAGGS, J. L., ONEILL, P. M., STORR, R. C., WARD, S. A., & PARK, B. K. (1995). THE EFFECT OF CHEMICAL SUBSTITUTION ON THE METABOLIC-ACTIVATION, METABOLIC DETOXICATION, AND PHARMACOLOGICAL ACTIVITY OF AMODIAQUINE IN THE MOUSE. Journal of Pharmacology and Experimental Therapeutics, 273(1), 393-404.
Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine.
Jewell, H., Maggs, J. L., Harrison, A. C., O'Neill, P. M., Ruscoe, J. E., & Park, B. K. (1995). Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine.. Xenobiotica; the fate of foreign compounds in biological systems, 25(2), 199-217. doi:10.3109/00498259509061845
1994
The effect of fluorine substitution on the metabolism and antimalarial activity of amodiaquine.
O'Neill, P. M., Harrison, A. C., Storr, R. C., Hawley, S. R., Ward, S. A., & Park, B. K. (1994). The effect of fluorine substitution on the metabolism and antimalarial activity of amodiaquine.. Journal of medicinal chemistry, 37(9), 1362-1370. doi:10.1021/jm00035a017
1993
The effect of fluorine substitution on the physicochemical properties and the analgesic activity of paracetamol.
Barnard, S., Storr, R. C., O'Neill, P. M., & Park, B. K. (1993). The effect of fluorine substitution on the physicochemical properties and the analgesic activity of paracetamol.. The Journal of pharmacy and pharmacology, 45(8), 736-744. doi:10.1111/j.2042-7158.1993.tb07099.x
2-Methyl-5,6-dimethylenepyrimidin-4-one: A Novel Diene
Tomé, A. C., O'Neill, P. M., Storr, R. C., & Cavaleiro, J. A. S. (1993). 2-Methyl-5,6-dimethylenepyrimidin-4-one: A Novel Diene. Synlett, 1993(05), 347-348. doi:10.1055/s-1993-22450
1992
Heterocyclic fused 2,5-dihydrothiophene S,S-dioxides as precursors to heterocyclic o-quinodimethanes
Chaloner, L. M., Crew, A. P. A., O'Neill, P. M., Storr, R. C., & Yelland, M. (1992). Heterocyclic fused 2,5-dihydrothiophene S,S-dioxides as precursors to heterocyclic o-quinodimethanes. Tetrahedron, 48(37), 8101-8116. doi:10.1016/s0040-4020(01)80480-4