Skip to main content
What types of page to search?

Alternatively use our A-Z index.

Paul O'Neill

Professor Paul O'Neill
BSc Hons PhD CChem MRSC

Contact

P.M.Oneill01@liverpool.ac.uk

Medicinal Chemistry Group

+44 (0)151 794 1133

+44 (0)151 794 3553

Professional Activities

Conference Roles

  • From artemisinin to tetraoxane-based antimalarial drug candidates, by Invitation (25th Annual Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), Liverpool John Moore's University, 2017)
  • Antimalarial Peroxide Probe and Candidate Synthesis, Keynote/Plenary by Invitation (Peakdale molecular 'synthesis in drug discovery and development' 4th symposium, Liverpool Hope University, 2016)
  • From artemisinin to a tetraoxane-based antimalarial drug candidate that circumvents K13- dependent clinical artemisinin resistance , Keynote/Plenary by Invitation (Bioactive Natural Products: translating promise into practice, at St Catherine’s College, Oxford University, 2016)
  • Endoperoxide Antimalarial Drug Development and Mechanism of Action, by Invitation (New Horizons and Emerging Biomedical Challenges for Biophysics, University of Liverpool, 2016)
  • A tetraoxane-based antimalarial drug candidate that circumvents PfKelch 13-dependent artemisinin resistance, Keynote/Plenary by Invitation (13th Asia Pacific Federation of Pharmacologists (APFP) 2016, Bangkok Thailand, 2016)
  • E209, A Novel Tetraoxane Antimalarial Candidate, by Invitation (SCI Academic Drug Discovery 3, London, 2015)
  • From Synthetic Endoperoxide Drug Candidates to Dual Acting Peroxide Based Hybrids, by Invitation (Shanghai Institution of Organic Chemistry, Shanghai, China, 2014)
  • Third Generation Tetraoxane Antimalarials, by Invitation (Institution of Biomedical Sciences, Fudan, University, Shanghai, China, 2014)
  • Development of a new generation of antimalaria lead quinolones targeting the mitochondrial respiratory pathway for the treatment and prophylaxis of uncomplicated malaria, Keynote/Plenary by Invitation (London School of Tropical medicine Hygiene, Emerging Paradigms in Anti-infective Drug Design, 17th Sept, , 2012)
  • Antimalarial Drug Discovery at the University of Liverpool, by Invitation (3rd Annual Georgia Nanotechnology & Infectious Diseases Symposium, Mercer University, Atlanta , USA, 2012)
  • From Candidate Selection of Synthetic Peroxides to Lead Optimisation of Quinolone Inhibitors of PfNDH2, by Invitation (UCL (London) Dept Seminar, 2012)
  • Antimalarial Drug Discovery at Liverpool, by Invitation (GSK Tres Cantos,Madrid, Spain, 2012)
  • Antimalarial Tetraoxanes; Candidate selection and back-up programme, by Invitation (EU FP6, 2011)
  • Drug Development of 1,2,4,5-Teraoxanes, by Invitation (RSC British High Commission, 2011)
  • From candidate selection of the first Tetraoxane Drug Candidate RKA 182 to the Discovery of Picomola, Keynote/Plenary by Invitation (RSC, London School of Tropical Medicine and Hygiene, 2010)
  • Antimalarial Drug Discovery at the University of Liverpool, by Invitation (Pfizer, Sandwich, Kent, 2010)
  • From candidate selection of the first Tetraoxane Drug Candidate RKA 182 and Appropriate Back-ups, Keynote/Plenary by Invitation (EFMC Sponsored 2nd National Conference on Medicinal Chemistry, Coimbra, Portugal, 2010)
  • Update on Tetraoxane Drug Development, by Invitation (St Georges Hospital, London, 2010)
  • Synthesis in Medicinal Chemistry, Keynote/Plenary by Invitation (Peakdale Molecular Symposium, Manchester, 2010)
  • Medicinal Chemistry of Quinoline and Peroxide Antimalarials, by Invitation (Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, 31077 Toulouse Cedex 4, France, 2010)
  • Antimalarial Drug Discovery in Academia; Discovery of Isoquine, FAQ4 and RKA182 , Keynote/Plenary by Invitation (British High Commission and RSC , Singapore, 2010)
  • Antimalarial Drug Discovery in Academia , Keynote/Plenary by Invitation (1st RSC China-UK Symposium on Medicinal Chemistry, Shanghai, China, 2009)
  • Synthetic Approaches to Endoperoxide Antimalarials, by Invitation (SCI Conference orgnaised by the SCI Young Chemists Panel , 2009)
  • Selection of RKA 182 as the first tetraoxane antimalarial drug candidate , Keynote/Plenary by Invitation (Keystone Symposia, Breckenridge Colorado, USA, 2009)
  • From the Natural Herb Qinghaosu (Artemisinin) to Orally Active Synthetic Endoperoxide Antima, by Invitation (University of Bangor, 2008)
  • Antimalarial Chemotherapy In the 21st Century; Advances in Drugs Targeting the Hemoglobin Degradatio, by Invitation (University of Warwick, 2008)
  • Advances in the Medicinal Chemistry of 4-Aminoquinolines, by Invitation (ACS Conference , Boston, 2007)
  • From the Natural Herb Extract Quinghaosu (Artemisinin) to Orally Active Synthetic Endoperoxide Antim, by Invitation (ESB, 2007)
  • Recent Advances in the Development of Drugs Targeting the Hemoglobin Degradation Pathway, Keynote/Plenary by Invitation (ACS Medicinal Chemistry & Bioorganic Chemistry Foundation, 2007)
  • Evidence for a Common Iron Dependent Mechanism of Action for Diverse Endoperoxide Antimalarials, by Invitation (EU COST, 2006)
  • A 4-Aminoquinoline Antimalarial for the 21st Century , by Invitation ((IUPHAR) Congress of Pharmacology, 2006)
  • The Drug Hybrid Approach to Antimalarial Chemotherapy, by Invitation (ISSX, 2006)
  • Toward a 21st Century Replacement for Chloroquine and Amodiaquine , by Invitation (EU COST Initiative, 2005)

Examination Roles

  • University of Glasgow, PhD (2016)
  • Imperial College London, PhD (2015)
  • University of East Anglia, PhD (2015)
  • University of Cape Town South Africa, PhD (2014)
  • University of Leeds, PhD (2013)
  • Imperial College, University of London, UK, PhD (2012)
  • Imperial College, University of London, UK, PhD (2011)
  • University of Dublin, PhD (2011)
  • University of Cape Town South Africa, PhD (2010)
  • University of Montpellier (France), PhD (2010)
  • University of Montpellier (France), PhD (2010)
  • University of Manchester, PhD (2007)

Organisations I have been associated with

  • Eisai (2014 - present)
  • AWOL (LSTM) (2014 - present)
  • Astra Zeneca (2014 - present)
  • Abbvie (2015 - present)
  • Open Lab Foundation (GSK) (Tres Cantos) (2015 - 2016)
  • GSK (2010 - 2015)
  • Bayer (2006 - 2010)

Professional Body Memberships

  • American Chemical Society (ACS Division of Organic Chemistry, 2007 - 2010)
  • Royal Society of Chemistry (Member, 2002 - 2010)