Research
In addition to pharmacogenetics and Epilepsy research, Sir Pirmohamed is a member of:
• Drug Safety
• NW England MRC Fellowship Scheme in Clinical Pharmacology and Therapeutics
Research groups
Research grants
Clinical Lecturer position in Clinical Pharmacology & Therapeutics
LABCORP DRUG DEVELOPMENT (UK)
September 2020 - August 2024
An Adaptive-design Randomised Trial of Baclofen in the Treatment of Alcohol Use Disorder in Patients with Liver Cirrhosis
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
October 2021 - March 2027
Medicines Data Resource
HEALTH DATA RESEARCH UK - HDRUK (UK)
April 2022 - March 2023
Genomic Medicine Service Alliance (GMSA)
MANCHESTER UNIVERSITY NHS FOUNDATION TRUST (UK)
March 2020 - August 2025
Two-way risk communication mobile application versus traditional methods of adverse drug reaction reporting in Uganda: a randomized controlled trial
MEDICAL RESEARCH COUNCIL
January 2022 - January 2025
Provision of a MassArray Mass-spectrometry based multiplex genotyping platform (Agena Biosciences).
MEDICAL RESEARCH COUNCIL
July 2023 - June 2025
The organisation and diffusion of translational research: Can cardiovascular medicine learn from oncology? Case studies of pharmacogenomics in the NHS
ECONOMIC AND SOCIAL RESEARCH COUNCIL
September 2022 - August 2025
Understanding adverse drug reactions of dolutegravir and isoniazid in HIV-positive Ugandans: incidence, risk factors, management and patient-reporting
MEDICAL RESEARCH COUNCIL
January 2023 - December 2027
Personalising renal function monitoring and interventions in people living with heart failure: RENAL-HF (RENAL-HF)
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
February 2022 - July 2027
Improving the utility of dihydropyrimidine dehydrogenase genetic testing in the NHS
NHS RACE AND HEALTH OBSERVATORY (UK)
April 2022 - October 2025
A personalised approach to manage adverse reactions to CFTR modulator therapy in patients with cystic fibrosis
MEDICAL RESEARCH COUNCIL
November 2022 - October 2025
Centre for Drug Safety (CDSS) (funding for salaries)
LIVERPOOL UNIVERSITY HOSPITALS NHS FOUNDATION TRUST (UK)
May 2020 - March 2022
Pharmacogenetics of Steroid-Induced Glaucoma
FIGHT FOR SIGHT (UK)
January 2020 - April 2025
Better Care Northern Partnership
HEALTH DATA RESEARCH UK - HDRUK (UK)
May 2020 - March 2028
NIHR ARC 2 national social care implementation projects
DEPARTMENT OF HEALTH & SOCIAL CARE (UK), LCCG - LIVERPOOL CLINICAL COMMISSIONING GROUP (UK)
October 2019 - March 2026
Accelerating Research & Development for Advanced Therapies (ARDAT)
BAYER AG (GERMANY), EUROPEAN COMMISSION
November 2020 - October 2025
Postdoctoral Fellowship - Dr Richard Turner
HEALTH EDUCATION ENGLAND (UK)
February 2018 - July 2023
Pharmacogenetics & Stratified Medicine Network
PRECISION MEDICINE CATAPULT LIMITED (UK)
October 2016 - September 2017
Warfarin Global Health Research Group (WarPATH)
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
June 2017 - August 2022
Support for the Pharmacology Research Portfolio
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
April 2019 - March 2020
A new generation of Crystallographic detector for Multi-user Barkla X-ray laboratory
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
July 2017 - July 2018
A multimodal imaging platform with real-time super-resolution for research across the life sciences
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
May 2018 - April 2019
Alcohol dependence and associated disease: determinants, pathogenesis and treatment (Andrew Thompson)
MEDICAL RESEARCH COUNCIL
February 2018 - September 2021
Immune-checkpoint therapy in non-small cell lung carcinoma: molecular characterisation of tumour microenvironment to improve anti-PD1/PD-L1 drug class.
MEDICAL RESEARCH COUNCIL
August 2017 - February 2021
MRC Innovation Fellowship (Boyd)
MEDICAL RESEARCH COUNCIL
August 2017 - May 2021
The role of transporters in the uptake of AV-101
VISTAGEN THERAPEUTICS, INC (USA)
September 2017 - February 2023
UK pharmacogentics and stratified medicine network
NORTHERN HEALTH SCIENCE ALLIANCE LIMITED (UK)
October 2016 - September 2018
Support for the Pharmacogenetics and Stratified Medicine Network
NHS ENGLAND (UK)
October 2017 - October 2018
Magic Study
ALDER HEY CHILDREN'S CHARITY (UK)
March 2017 - February 2018
Bench Fees - Wedad Alhassan K Mawkili - 201309650
ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)
February 2018 - September 2021
Support for the Pharmacogenetics and Stratified Medicine Network
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
November 2017 - July 2019
PGX Network Sponsorship
UCB BIOPHARMA SPRL (BELGIUM), UCB PHARMA LTD (UK)
October 2016 - September 2018
Can the SAVSNET informatics systems be used to improve signal identification and reporting of adverse drug reactions?
DEPARTMENT FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS (UK)
February 2019 - October 2022
UK pharmacogenetics and stratified medicine network
ACADEMIC HEALTH SCIENCE NETWORK NW COAST (NWCAHSN) (UK)
October 2016 - September 2017
Exploring the interaction of gut microbiome, genetic and immunological factors in gastrointestinal toxicity of immune checkpoint inhibitors.
MEDICAL RESEARCH COUNCIL
February 2018 - March 2021
Support for the Pharmacogenetics and Stratified Medicine Network
BRISTOL-MYERS SQUIBB PHARMACEUTICALS LTD (UK)
March 2018 - August 2018
Personalised Medicine Approaches for Space Exploration
EUROPEAN SPACE AGENCY (FRANCE)
April 2018 - September 2022
Development of screening approaches to assess to intrinsic immunogenicity of drugs and novel chemicals
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
March 2018 - May 2021
Systems pharmacology approaches to drug-induced hypersensitivity reactions
MALAYSIAN GOVERNMENT (MALAYSIA)
March 2015 - February 2018
Developing personalised renal function monitoring (CLAHRC)
LIVERPOOL HEART AND CHEST NHS FOUNDATION TRUST (UK)
April 2015 - December 2018
Drug induced liver injury due to tuberculosis treatment: predictive biomarkers and genetic associations
DEPARTMENT FOR BUSINESS, INNOVATION AND SKILLS (UK)
March 2015 - September 2019
Ubiquitous Pharmacogenomics (U-PGx): Making actionable pharmacogenomic data and effective treatment optimization accessible to every European citizen.
EUROPEAN COMMISSION
January 2016 - December 2021
Bench Fees for Gospel Nwikue.
RIVERS STATE SUSTAINABLE DEVELOPMENT AGENCY (NIGERIA)
February 2015 - January 2018
Liverpool Health Genomics Laboratory
LIVERPOOL HEALTH PARTNERS (UK)
March 2015 - February 2018
North West England MRC Fellowship Scheme in Clinical Pharmacology and Therapeutics
ELI LILLY AND COMPANY LTD (UK), MEDICAL RESEARCH COUNCIL, NOVARTIS PHARMACEUTICALS UK LTD (UK), ROCHE PRODUCTS LTD (UK), UCB PHARMA LTD (UK)
May 2016 - June 2025
2014 allocation - Wellcome ISSF non clinical fellowships
WELLCOME TRUST (UK)
May 2015 - October 2018
Identification of efficacy predictors for clopidogrel using integrated systems pharmacology approach
DEPARTMENT FOR BUSINESS, INNOVATION AND SKILLS (UK)
February 2016 - July 2018
A prospective investigation of β-lactam allergy in patients with cystic fibrosis to define drug immunogenicity
CYSTIC FIBROSIS TRUST (UK)
December 2011 - August 2016
A pragmatic randomised controlled trial comparing the effectiveness and cost effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of Standard And New Antiepileptic Drugs (SANAD-II)
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
June 2012 - November 2019
The response of the liver to chemical stress, a molecular and proteomic investigation of paracetamol-induced hepatotoxicity.
WELLCOME TRUST (UK)
September 2001 - September 2005
Genetic predisposition to clozapine agranulocytosis
MERSEY CARE NHS FOUNDATION TRUST (UK)
March 2011 - March 2019
North West Coast CLAHRC
DEPARTMENT OF HEALTH & SOCIAL CARE (UK), LCCG - LIVERPOOL CLINICAL COMMISSIONING GROUP (UK), MERSEY CARE NHS FOUNDATION TRUST (UK)
January 2014 - June 2021
PhD Studentship.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
October 2004 - September 2007
NHS informatics support to improve research recruitment
THE CHESHIRE AND MERSEYSIDE COMPREHENSIVE LOCAL RESEARCH NETWORK (UK)
January 2013 - March 2014
The role of multidrug transporters in causing pharmacoresistance in epilepsy
MEDICAL RESEARCH COUNCIL
January 2010 - January 2013
Chemical, clinical and molecular aspects of adverse drug reactions in man.
WELLCOME TRUST (UK)
January 1999 - August 2001
Psoriasis stratification to optimise relevant therapy (PSORT)
MEDICAL RESEARCH COUNCIL
September 2014 - May 2021
The Interactions Between Clostridium Difficile, Intestinal Microbiota and the Host Response in Hospitalised Patients.
MEDICAL RESEARCH COUNCIL
September 2012 - March 2018
Fighting Drug Failure (Marie Curie Fellowship)
EUROPEAN COMMISSION
October 2009 - September 2013
Phase IIa, randomised, open label, controlled trial of rostuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis (PROteKT)
THE MOULTON CHARITABLE FOUNDATION (UK)
June 2014 - January 2018
North of England Pharmacology Research Programme
THE CHESHIRE AND MERSEYSIDE COMPREHENSIVE LOCAL RESEARCH NETWORK (UK)
May 2011 - June 2015
Genetic mechanisms of HIV-related lipodystrophy.
MEDICAL RESEARCH COUNCIL
October 2002 - September 2005
Folate Augmentation of Treatment - Evaluation for Depression: a randomised controlled trial (FoIATED).
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
October 2006 - June 2011
The immunological response consequences of metabolic drug activation by dendritic cells.
WELLCOME TRUST (UK)
April 2006 - April 2009
Designing and analysing multi-arm multi-stage clinical trials with one or more endpoints
MEDICAL RESEARCH COUNCIL
September 2012 - June 2016
TAILoR (TelmisArtan and InsuLin Resistance in HIV): A dose-ranging Phase II randomised open trial of telmistartan as a strategy for the reduction of insulin resistance in HIV-positive individuals on Combination Antiretroviral Therapy (CART)
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
January 2012 - February 2020
Genetics of non-steroidal anti-inflammatory drugs (NSAIDs)-induced peptic ulceration: a genome wide association study.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
July 2010 - June 2011
Utilisation of the COTOX trial to study the biological mechanisms of co-trimoxazole hypersensitivity in HIV disease.
MEDICAL RESEARCH COUNCIL
January 1999 - January 2002
Mechanisms of toxicity of protease inhibitions.
AVERT (UK)
October 1998 - September 2001
Exploring oxidative stress pathways in epilepsy
REPUBLIC OF IRAQ MINISTRY OF EDUCATION🚩
October 2014 - September 2017
Randomisation within the database: a feasibility trial evaluating the comparative effects of statins in a research network of general practices RETRO-PRO
WELLCOME TRUST (UK)
January 2010 - December 2017
Non-Attrition HAART nanoparticle therapies for HIV/AIDS Drug Delivery
ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL
May 2009 - October 2012
Bench Fees for Azizan Binti Ab Ghani
MINISTRY OF HEALTH MALAYSIA (MALAYSIA)
September 2010 - August 2014
Hepatoxicity of antituberculosis drugs: An investigation of mechanisms.
MEDICAL RESEARCH COUNCIL
May 2001 - April 2004
Inflammatory bowel disease in children
CROHNS IN CHILDHOOD RESEARCH ASSOCIATION (UK)
December 2013 - February 2017
Prospective registry of inflammatory bowel diseases
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
September 2010 - August 2011
Variability in response to warfarin: a prospective analysis of pharmacogenetic and environmental factors.
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
September 2004 - October 2009
The role of transporter proteins in the efficacy of imatinib and newer tyrosine kinase inhibitors in chronic myeloid leukaemia.
KAY KENDALL LEUKAEMIA FUND (UK)
June 2008 - June 2013
Adverse Drug Reactions in Children.
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
December 2007 - April 2013
Pharmacogenetics of Methadone response
NATIONAL HEALTH AND MEDICAL RESEARCH COUNCIL (AUSTRALIA)
September 2010 - February 2013
Department of Health Sponsored chair in pharmacogenetics.
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
September 2007 - March 2019
Investigation into the role of mycobacterial antigens in early mortality in patients treated for TB.
WELLCOME TRUST (UK)
November 2005 - December 2010
MerseyBeat - Best Evidence, Application and Translation of research
LIVERPOOL PRIMARY CARE TRUST (UK)
March 2008 - September 2019
A pharmacogenomic approach to coumarin anticoagulant therapy (PACT)
EUROPEAN COMMISSION
October 2008 - March 2013
Paediatric Pharmacology studies
ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)
July 2014 - June 2017
Applying innovative technologies to improve the benefit-risk ratio of drugs: developing a national resource underpinned by the infrastructure of the MRC Centre for Drug Safety Science
MEDICAL RESEARCH COUNCIL
April 2015 - March 2016
EURIPIDES - EUropean Research initiative to develop Imaging Probes for early In-vivo Diagnosis and Evaluation of response to therapeutic Substances
EUROPEAN COMMISSION
February 2008 - January 2013
The role of peripheral and liver-associated T lymphocytes in pathogenesis of alcholic liver disease.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
May 2004 - October 2005
Epidemiology of adverse drug reactions in hospitals.
MEDICINES CONTROL AGENCY
April 2001 - November 2003
The Role of Multidrug Transporters in causing Pharmacoresistance in Epilepsy
MEDICAL RESEARCH COUNCIL
January 2013 - August 2013
Investigation into the mechanisms of lamotrigine cutaneous toxicity.
MACMILLAN CANCER SUPPORT (UK)
February 1998 - March 2001
Genetic markers for carbamazepine-induced hypersensitivty syndrome
EPILEPSY RESEARCH INSTITUTE UK (UK)
June 2012 - November 2013
P-glycoprotein and efficacy of imatinib (Glivec).
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
June 2002 - October 2003
Liverpool Health Partners - Drugs Theme Project Manager
LIVERPOOL HEALTH PARTNERS (UK)
April 2013 - September 2015
Effects of NRTIs on adipose function.
PENNINE ACUTE HOSPITALS NHS TRUST (UK)
January 2006 - June 2009
An investigation of the functional and regulatory role of GST-PI during chemical stress.
WELLCOME TRUST (UK)
September 2000 - April 2004
Effects within HAART on markers of adipose function.
PENNINE ACUTE HOSPITALS NHS TRUST (UK)
December 2005 - June 2009
Pharmacogenetics of antimicrobial drug-induced liver injury.
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
October 2004 - April 2008
Pharmacogenetics of GABAergic mechanisms of benefit and harm in epilepsy.
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
February 2005 - November 2010
North West Hub for Trial Methodology Research (NWHTMR)
MEDICAL RESEARCH COUNCIL
October 2008 - August 2014
Clerical assistant to work on EU-PACT study
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
July 2012 - March 2013
WEB-RADR
EUROPEAN COMMISSION
September 2014 - August 2017
Pharmacogenetics of NSAIDs
DELTA STATE UNIVERSITY (NIGERIA)
October 2011 - September 2014
Drugs used in the treatment of alcohol dependency – a UK wide drug utilisation study
MERSEY CARE NHS FOUNDATION TRUST (UK)
July 2012 - September 2015
Clostridium difficile infection – developing biomarkers of pathogenicity and disease relapse
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
March 2010 - March 2011
A retrospective cohort study of children and young people taking warfarin at Alder Hey
CHILDRENS RESEARCH FUND (UK)
January 2010 - December 2010
Development and implementation of a model to improve alcohol services in primary and secondary care.
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
September 1998 - May 2001
Platelet polymorphism study.
BLACKPOOL VICTORIA HOSPITAL NHS TRUST (UK)
October 2006 - September 2007
Epilepsy Pharmacogenomics: delivering biomarkers for clinical use (EpiPGX)
EUROPEAN COMMISSION
October 2011 - September 2016
NIHR Senior Investigator Award
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
April 2008 - March 2020
Pharmacogenetics of statin-induced muscle toxicity: Exploration using the UK general practice research database (GRPD).
MEDICAL RESEARCH COUNCIL
March 2009 - February 2013
The Pharmacology of Nevirapine in Malawian Patients: Implications for Dosing and Understanding of Hypersensitivity Reactions.
WELLCOME TRUST (UK)
September 2006 - October 2009
Definition of chemical and immunological signals associated with the development of contact dermatitis.
BRITISH SKIN FOUNDATION (UK)
January 2006 - December 2008
Metformin and genetic polymorphisms of organic cation transporters.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
May 2005 - December 2008
Quantitative high-throughput proteomics for biomedical research.
MEDICAL RESEARCH COUNCIL
March 2005 - March 2008
Cost-effectiveness of pre-prescription pharmacogenetic testing for irinotecan.
NATIONAL ASSEMBLY FOR WALES (UK)
February 2007 - September 2008
Do transporter proteins contribute to clinical resistance to imatinib in chronic myeloid leukaemia? A combined study in Liverpool and Glasgow, correlating transporter expression and function with imatinib uptake and efflux.
LEUKAEMIA RESEARCH FUND
August 2004 - June 2008
SANAD and MESS-Linked DNA bank and relational database.
WELLCOME TRUST (UK)
June 2004 - May 2005
NIHR Portfolio Pharmacology studies
THE CHESHIRE AND MERSEYSIDE COMPREHENSIVE LOCAL RESEARCH NETWORK (UK)
February 2012 - March 2014
SAFE-T
EUROPEAN COMMISSION
January 2011 - June 2015
Cell culture laboratory.
WELLCOME TRUST (UK)
June 2000 - April 2001
Investigation of the role of ABCB5 in corticosteroid transport and response in IBD
NAT ASSOC FOR COLITIS & CROHNS DISEASE (UK)
November 2009 - February 2012
PREDICTION-ADR: Personalisation of tREatment In Cardiovascular disease through next generation sequencing in Adverse Drug Reactions
EUROPEAN COMMISSION
September 2013 - February 2017
Antiepileptic drug transport at the blood-brain barrier; more than just P-glycoprotein
EPILEPSY RESEARCH INSTITUTE UK (UK)
October 2010 - September 2014
Individual susceptibility to Clostridium Difficile Toxin Disease.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
January 2000 - August 2004
PAMPERS - Paediatric Accelerator Mass Spectrometry Evaluation Research Study
INSTYTUT FARMACEUTYCZNY (POLAND), MEDICAL RESEARCH COUNCIL
September 2011 - December 2014
High Throughput Sequencing Hub for the North of England
MEDICAL RESEARCH COUNCIL
September 2009 - December 2012
BRC safety of antimicrobials theme.
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
September 2007 - March 2012
Andrew Swale - NIHR fellowship
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
April 2012 - September 2013
Support for the Pharmacology Research Portfolio
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
August 2014 - March 2018
Research collaborations
Drs Panos Deloukas/Alison Coffey
Wellcome Trust Sanger Institute
Large scale genotyping on pharmacogenetics projects
Dr Michael Johnson
Imperial College of Science, Technology
Collaboration on epilepsy pharmacogenetics, and collection of DNA samples from epielpsy patients