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Munir Pirmohamed

Professor Sir Munir Pirmohamed
MB ChB (Hons), MRCP, PhD, FRCP, FRCP(E), FBPharmacolS

Professor (Clin,Hcc)
Pharmacology & Therapeutics
Part of
Institute of Systems, Molecular & Integrative Biology
Faculty of Health and Life Sciences

Contact

Munirp@liverpool.ac.uk

http://liv.ac.uk/pharmacogenetics/

+44 (0)151 794 5549

Publications

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2024

To DRESS, or Not to DRESS, That Is the Question

Pirmohamed, M. (2024). To DRESS, or Not to DRESS, That Is the Question. The Journal of Allergy and Clinical Immunology: In Practice, 12(11), 3014-3015. doi:10.1016/j.jaip.2024.08.048

DOI
10.1016/j.jaip.2024.08.048
Journal article

Patient preferences for using remote care technology in heart failure: A discrete choice experiment (Preprint)

DOI
10.2196/preprints.68022
Preprint

Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers

DOI
10.22541/au.172216154.44094109/v1
Preprint

Urine metabolomics signature reveals novel determinants of adrenal suppression in children taking inhaled corticosteroids to control asthma symptoms.

Tran, D. T., Chen, Y., Zheng, Y., Hecker, J., Hawcutt, D. B., Pirmohamed, M., . . . Dahlin, A. (2024). Urine metabolomics signature reveals novel determinants of adrenal suppression in children taking inhaled corticosteroids to control asthma symptoms.. Immunity, inflammation and disease, 12(7), e1315. doi:10.1002/iid3.1315

DOI
10.1002/iid3.1315
Journal article

P111 Immuno-pathological characteristics associated with immune-checkpoint inhibitor colitis

Swaminathan, M., Luchian, A., Ressel, L., Burdak-Rothkamm, S., Sacco, J., Pirmohamed, M., & Mark Pritchard, D. (2024). P111 Immuno-pathological characteristics associated with immune-checkpoint inhibitor colitis. In Poster Presentations (pp. A117-A118). BMJ Publishing Group Ltd and British Society of Gastroenterology. doi:10.1136/gutjnl-2024-bsg.193

DOI
10.1136/gutjnl-2024-bsg.193
Conference Paper

P140 Investigating circulating miRNAs as diagnostic and prognostic biomarkers of immune checkpoint inhibitor-related colitis

Swaminathan, M., Olsson-Brown, A., Sacco, J., Pirmohamed, M., Parker, J., Yachi, P., & Mark Pritchard, D. (2024). P140 Investigating circulating miRNAs as diagnostic and prognostic biomarkers of immune checkpoint inhibitor-related colitis. In Poster Presentations (pp. A137-A138). BMJ Publishing Group Ltd and British Society of Gastroenterology. doi:10.1136/gutjnl-2024-bsg.222

DOI
10.1136/gutjnl-2024-bsg.222
Conference Paper

Genetic Determinants of Thiazide-Induced Hyperuricemia, Hyperglycemia, and Urinary Electrolyte Disturbances - A Genome-Wide Evaluation of the UK Biobank.

Asiimwe, I. G., Walker, L., Sofat, R., Jorgensen, A. L., Pirmohamed, M., & Multimorbidity Mechanism and Therapeutic Research Collaborative (MMTRC). (2024). Genetic Determinants of Thiazide-Induced Hyperuricemia, Hyperglycemia, and Urinary Electrolyte Disturbances - A Genome-Wide Evaluation of the UK Biobank.. Clinical pharmacology and therapeutics. doi:10.1002/cpt.3229

DOI
10.1002/cpt.3229
Journal article

Cancer pharmacogenomics

Pirmohamed, S. M. (2024). Cancer pharmacogenomics. Pathology, 56, S22. doi:10.1016/j.pathol.2023.12.085

DOI
10.1016/j.pathol.2023.12.085
Journal article

Preventing adverse drug reactions

Pirmohamed, S. M. (2024). Preventing adverse drug reactions. Pathology, 56, S18-S19. doi:10.1016/j.pathol.2023.12.073

DOI
10.1016/j.pathol.2023.12.073
Journal article

Chapter 40 Pharmacogenomics in cardiovascular disease

Turner, R. M., & Pirmohamed, M. (2024). Chapter 40 Pharmacogenomics in cardiovascular disease. In Diagnostic Molecular Pathology (pp. 623-642). Elsevier. doi:10.1016/b978-0-12-822824-1.00001-8

DOI
10.1016/b978-0-12-822824-1.00001-8
Chapter

Glycolysis: An early marker for vancomycin-specific T-cell activation.

Gardner, J., Hammond, S., Jensen, R., Gibson, A., Krantz, M. S., Ardern-Jones, M., . . . Naisbitt, D. J. (2024). Glycolysis: An early marker for vancomycin-specific T-cell activation.. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 54(1), 21-33. doi:10.1111/cea.14423

DOI
10.1111/cea.14423
Journal article

Patients with <scp>naproxen‐induced</scp> liver injury display T‐cell memory responses toward an oxidative (S)‐<scp>O‐Desmethyl</scp> Naproxen metabolite but not the acyl glucuronide

Thomson, P., Fragkas, N., Kafu, L. M., Aithal, G. P., Lucena, M. I., Terracciano, L., . . . Naisbitt, D. J. (n.d.). Patients with <scp>naproxen‐induced</scp> liver injury display T‐cell memory responses toward an oxidative (S)‐<scp>O‐Desmethyl</scp> Naproxen metabolite but not the acyl glucuronide. Allergy. doi:10.1111/all.15830

DOI
10.1111/all.15830
Journal article

Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-Desmethyl Naproxen metabolite but not the acyl glucuronide

Thomson, P., Fragkas, N., Kafu, L. M., Aithal, G. P., Lucena, M. I., Terracciano, L., . . . Naisbitt, D. J. (2023). Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-Desmethyl Naproxen metabolite but not the acyl glucuronide. In ALLERGY. doi:10.1111/all.15830

DOI
10.1111/all.15830
Conference Paper

Pharmacogenetics for the prescriber

Pirmohamed, M. (2024). Pharmacogenetics for the prescriber. Medicine, 52(1), 11-14. doi:10.1016/j.mpmed.2023.10.002

DOI
10.1016/j.mpmed.2023.10.002
Journal article

Response to the comment on: Exploring the impact of design criteria for reference sets on performance evaluation of signal detection algorithms: The case of drug-drug interactions.

Kontsioti, E., Maskell, S., & Pirmohamed, M. (2024). Response to the comment on: Exploring the impact of design criteria for reference sets on performance evaluation of signal detection algorithms: The case of drug-drug interactions.. Pharmacoepidemiology and drug safety, 33(1), e5731. doi:10.1002/pds.5731

DOI
10.1002/pds.5731
Journal article

2023

<i>DPYD</i>genetic polymorphisms in non-European patients with severe fluoropyrimidine-related toxicity: A systematic review

DOI
10.1101/2023.12.11.23299813
Preprint

TNF-α induced extracellular release of keratinocyte high-mobility group box 1 in Stevens-Johnson syndrome/toxic epidermal necrolysis: Biomarker and putative mechanism of pathogenesis

Nwikue, G., Olsson-Brown, A., Aboheimed, N., Yip, V., Jolly, C., Luchian, A., . . . Carr, D. F. (2023). TNF-α induced extracellular release of keratinocyte high-mobility group box 1 in Stevens-Johnson syndrome/toxic epidermal necrolysis: Biomarker and putative mechanism of pathogenesis. JOURNAL OF DERMATOLOGY, 50(9), 1129-1139. doi:10.1111/1346-8138.16847

DOI
10.1111/1346-8138.16847
Journal article

The PREPARE study: benefits of pharmacogenetic testing are unclear - Authors' reply.

Swen, J. J., Manson, L. E. N., Böhringer, S., Pirmohamed, M., & Guchelaar, H. -J. (2023). The PREPARE study: benefits of pharmacogenetic testing are unclear - Authors' reply.. Lancet (London, England), 401(10391), 1851-1852. doi:10.1016/s0140-6736(23)00852-8

DOI
10.1016/s0140-6736(23)00852-8
Journal article

Increasing trend in hospitalisation due to adverse drug reactions: can we stem the tide?

Walker, L. E., & Pirmohamed, M. (2023). Increasing trend in hospitalisation due to adverse drug reactions: can we stem the tide?. Drug and therapeutics bulletin, 61(6), 87-91. doi:10.1136/dtb.2022.000050

DOI
10.1136/dtb.2022.000050
Journal article

TNF-α-Mediated Keratinocyte Expression and Release of Matrix Metalloproteinase 9: Putative Mechanism of Pathogenesis in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

Olsson-Brown, A., Yip, V., Ogiji, E. D., Jolly, C., Ressel, L., Sharma, A., . . . Carr, D. F. (2023). TNF-α-Mediated Keratinocyte Expression and Release of Matrix Metalloproteinase 9: Putative Mechanism of Pathogenesis in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 143(6), 1023-+. doi:10.1016/j.jid.2022.11.024

DOI
10.1016/j.jid.2022.11.024
Journal article

Facilitators and Barriers to Uptake of the Med Safety Mobile App for Adverse Drug Reaction Reporting by Health Workers in Uganda: A Qualitative Study

Kiguba, R., Zakumumpa, H., Ndagije, H. B., Mwebaza, N., Ssenyonga, R., Tregunno, P., . . . Pirmohamed, M. (2023). Facilitators and Barriers to Uptake of the Med Safety Mobile App for Adverse Drug Reaction Reporting by Health Workers in Uganda: A Qualitative Study. DRUG SAFETY. doi:10.1007/s40264-023-01303-6

DOI
10.1007/s40264-023-01303-6
Journal article

Characterization of Drug-Specific CD4+T-Cells Reveals Possible Roles of HLA Class II in the Pathogenesis of Carbamazepine Hypersensitivity Reactions

Jaruthamsophon, K., Thomson, P. J., Hammond, S., Zhang, E., Alfirevic, A., Sukasem, C., . . . Pirmohamed, M. (2023). Characterization of Drug-Specific CD4+T-Cells Reveals Possible Roles of HLA Class II in the Pathogenesis of Carbamazepine Hypersensitivity Reactions. CHEMICAL RESEARCH IN TOXICOLOGY. doi:10.1021/acs.chemrestox.2c00414

DOI
10.1021/acs.chemrestox.2c00414
Journal article

A "Bundle of Care" to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study

Jorgensen, A. L., Orrell, C., Waitt, C., Toh, C. -H., Sekaggya-Wiltshire, C., Hughes, D. A., . . . Pirmohamed, M. (2023). A "Bundle of Care" to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study. JMIR RESEARCH PROTOCOLS, 12. doi:10.2196/46710

DOI
10.2196/46710
Journal article

A “Bundle of Care” to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study (Preprint)

DOI
10.2196/preprints.46710
Preprint

Combinations of medicines in patients with polypharmacy aged 65-100 in primary care: Large variability in risks of adverse drug related and emergency hospital admissions.

Fahmi, A., Wong, D., Walker, L., Buchan, I., Pirmohamed, M., Sharma, A., . . . van Staa, T. P. (2023). Combinations of medicines in patients with polypharmacy aged 65-100 in primary care: Large variability in risks of adverse drug related and emergency hospital admissions.. PloS one, 18(2), e0281466. doi:10.1371/journal.pone.0281466

DOI
10.1371/journal.pone.0281466
Journal article

A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study.

Swen, J. J., van der Wouden, C. H., Manson, L. E., Abdullah-Koolmees, H., Blagec, K., Blagus, T., . . . Ubiquitous Pharmacogenomics Consortium. (2023). A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study.. Lancet (London, England), 401(10374), 347-356. doi:10.1016/s0140-6736(22)01841-4

DOI
10.1016/s0140-6736(22)01841-4
Journal article

Clinical Relevance of Drug-Drug Interactions With Antibiotics as Listed in a National Medication Formulary: Results From Two Large Population-Based Case-Control Studies in Patients Aged 65-100 Years Using Linked English Primary Care and Hospital Data

van Staa, T. P., Pirmohamed, M., Sharma, A., Buchan, I., & Ashcroft, D. M. (2023). Clinical Relevance of Drug-Drug Interactions With Antibiotics as Listed in a National Medication Formulary: Results From Two Large Population-Based Case-Control Studies in Patients Aged 65-100 Years Using Linked English Primary Care and Hospital Data. CLINICAL PHARMACOLOGY & THERAPEUTICS, 113(2), 423-434. doi:10.1002/cpt.2807

DOI
10.1002/cpt.2807
Journal article

Genome-wide analyses of platinum-induced ototoxicity in childhood cancer patients: Results of GO-CAT and United Kingdom MAGIC consortia.

Hurkmans, E. G. E., Klumpers, M. J., Dello Russo, C., De Witte, W., Guchelaar, H. -J., Gelderblom, H., . . . Te Loo, D. M. W. M. (2023). Genome-wide analyses of platinum-induced ototoxicity in childhood cancer patients: Results of GO-CAT and United Kingdom MAGIC consortia.. Frontiers in pharmacology, 13, 980309. doi:10.3389/fphar.2022.980309

DOI
10.3389/fphar.2022.980309
Journal article

<i>CYP3A</i> genetic variation and taxane-induced peripheral neuropathy: a systematic review, meta-analysis, and candidate gene study (vol 14, 1178421, 2023)

Mcevoy, L., Cliff, J., Carr, D. F., Jorgensen, A., Lord, R., & Pirmohamed, M. (2023). <i>CYP3A</i> genetic variation and taxane-induced peripheral neuropathy: a systematic review, meta-analysis, and candidate gene study (vol 14, 1178421, 2023). FRONTIERS IN PHARMACOLOGY, 14. doi:10.3389/fphar.2023.1274075

DOI
10.3389/fphar.2023.1274075
Journal article

A genome-wide association study of plasma concentrations of warfarin enantiomers and metabolites in sub-Saharan Black-African patients

Asiimwe, I., Zhang, E., Jorgensen, A., & Pirmohamed, M. (2023). A genome-wide association study of plasma concentrations of warfarin enantiomers and metabolites in sub-Saharan Black-African patients. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 89 (pp. 1248-1249). Retrieved from https://www.webofscience.com/

Conference Paper

A genome-wide association study of stable warfarin dose in sub-Saharan African patients

Asiimwe, I., Zhang, E., Jorgensen, A., & Pirmohamed, M. (2023). A genome-wide association study of stable warfarin dose in sub-Saharan African patients. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 89 (pp. 1249). Retrieved from https://www.webofscience.com/

Conference Paper

Blood group as a clinical risk factor in peptic ulcer disease: UK biobank analysis

McEvoy, L., Pirmohamed, M., Carr, D., & Jorgensen, A. (2023). Blood group as a clinical risk factor in peptic ulcer disease: UK biobank analysis. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 89 (pp. 1243). Retrieved from https://www.webofscience.com/

Conference Paper

Clinical Risk Factors in Peptic Ulcer Disease: UK Biobank Analysis

McEvoy, L., Pirmohamed, M., Carr, D., & Jorgensen, A. (2023). Clinical Risk Factors in Peptic Ulcer Disease: UK Biobank Analysis. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 180 (pp. 276). Retrieved from https://www.webofscience.com/

Conference Paper

Developing a warfarin dosing algorithm in patients with mechanical heart valves

Zhang, E., Stewart, A., Jorgensen, A., McEvoy, L., Carracedo, A. D., Foster, T., . . . Pirmohamed, M. (2023). Developing a warfarin dosing algorithm in patients with mechanical heart valves. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 89 (pp. 1249-1250). Retrieved from https://www.webofscience.com/

Conference Paper

Exploration of genetic risk factors associated with <i>Clostridium difficile</i> infection and nosocomial diarrhoea

Zhang, E., Miyajima, F., Carracedo, A. D., Thompson, A., & Pirmohamed, M. (2023). Exploration of genetic risk factors associated with <i>Clostridium difficile</i> infection and nosocomial diarrhoea. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 89 (pp. 1242-1243). Retrieved from https://www.webofscience.com/

Conference Paper

Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study

Kuan, V., Denaxas, S., Patalay, P., Nitsch, D., Mathur, R., Gonzalez-Izquierdo, A., . . . MMTRC. (2023). Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study. LANCET DIGITAL HEALTH, 5(1), E16-E27. doi:10.1016/S2589-7500(22)00187-X

DOI
10.1016/S2589-7500(22)00187-X
Journal article

Pharmacogenetics of taxane-induced peripheral neuropathy: A candidate gene study

McEvoy, L., Pirmohamed, M., Carr, D., Cliff, J., & Lord, R. (2023). Pharmacogenetics of taxane-induced peripheral neuropathy: A candidate gene study. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 89 (pp. 1243-1244). Retrieved from https://www.webofscience.com/

Conference Paper

Pharmacogenomics in cardiovascular disease

Turner, R. M., & Pirmohamed, M. (2024). Pharmacogenomics in cardiovascular disease. In Diagnostic Molecular Pathology (pp. 623-642). Elsevier. doi:10.1016/b978-0-12-822824-1.00001-8

DOI
10.1016/b978-0-12-822824-1.00001-8
Chapter

2022

The role of pharmacogenomics in contemporary cardiovascular therapy: a position statement from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy (vol 8, pg 85, 2022)

Magavern, E. F., Kaski, J. C., Turner, R. M., Drexel, H., Janmohamed, A., Scourfield, A., . . . Caulfield, M. J. (2022). The role of pharmacogenomics in contemporary cardiovascular therapy: a position statement from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy (vol 8, pg 85, 2022). EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY, 9(1), 116. doi:10.1093/ehjcvp/pvac038

DOI
10.1093/ehjcvp/pvac038
Journal article

A genome-wide association study of plasma concentrations of warfarin enantiomers and metabolites in sub-Saharan black-African patients.

Asiimwe, I. G., Blockman, M., Cohen, K., Cupido, C., Hutchinson, C., Jacobson, B., . . . Pirmohamed, M. (2022). A genome-wide association study of plasma concentrations of warfarin enantiomers and metabolites in sub-Saharan black-African patients.. Frontiers in pharmacology, 13, 967082. doi:10.3389/fphar.2022.967082

DOI
10.3389/fphar.2022.967082
Journal article

Effectiveness of the Med Safety mobile application in improving adverse drug reaction reporting by healthcare professionals in Uganda: a protocol for a pragmatic cluster-randomised controlled trial

Kiguba, R., Mwebaza, N., Ssenyonga, R., Ndagije, H. B., Nambasa, V., Katureebe, C., . . . Pirmohamed, M. (2022). Effectiveness of the Med Safety mobile application in improving adverse drug reaction reporting by healthcare professionals in Uganda: a protocol for a pragmatic cluster-randomised controlled trial. BMJ OPEN, 12(7). doi:10.1136/bmjopen-2022-061725

DOI
10.1136/bmjopen-2022-061725
Journal article

COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records.

Thygesen, J. H., Tomlinson, C., Hollings, S., Mizani, M. A., Handy, A., Akbari, A., . . . Longitudinal Health and Wellbeing COVID-19 National Core Study and the CVD-COVID-UK/COVID-IMPACT Consortium. (2022). COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records.. The Lancet. Digital health, 4(7), e542-e557. doi:10.1016/s2589-7500(22)00091-7

DOI
10.1016/s2589-7500(22)00091-7
Journal article

Pharmacogenomics decision support in the U-PGx project: Results and advice from clinical implementation across seven European countries.

Blagec, K., Swen, J. J., Koopmann, R., Cheung, K. -C., Crommentuijn-van Rhenen, M., Holsappel, I., . . . Ubiquitous Pharmacogenomics Consortium. (2022). Pharmacogenomics decision support in the U-PGx project: Results and advice from clinical implementation across seven European countries.. PloS one, 17(6), e0268534. doi:10.1371/journal.pone.0268534

DOI
10.1371/journal.pone.0268534
Journal article

GENOME WIDE ANALYSIS IDENTIFIES POTENTIAL MECHANISMS OF NON-ALCOHOLIC FATTY LIVER DISEASE

Ho, B., Thompson, A., Jorgensen, A., & Pirmohamed, M. (2022). GENOME WIDE ANALYSIS IDENTIFIES POTENTIAL MECHANISMS OF NON-ALCOHOLIC FATTY LIVER DISEASE. In GUT Vol. 71 (pp. A14-A15). doi:10.1136/gutjnl-2022-BSG.25

DOI
10.1136/gutjnl-2022-BSG.25
Conference Paper

T-cell-mediated hypersensitivity to lumacaftor and ivacaftor in cystic fibrosis

Semic-Jusufagic, A., Ogese, M. O., Edwards, C., Wilkinson, M., Nissenbaum, C., Lee, T., . . . Naisbitt, D. J. (2022). T-cell-mediated hypersensitivity to lumacaftor and ivacaftor in cystic fibrosis. PEDIATRIC ALLERGY AND IMMUNOLOGY, 33(6). doi:10.1111/pai.13815

DOI
10.1111/pai.13815
Journal article

Socioeconomic and health factors related to polypharmacy and medication management: analysis of a Household Health Survey in North West Coast England

Downing, J., Taylor, R., Mountain, R., Barr, B., Daras, K., Comerford, T., . . . Alfirevic, A. (2022). Socioeconomic and health factors related to polypharmacy and medication management: analysis of a Household Health Survey in North West Coast England. BMJ Open, 12(5), e054584. doi:10.1136/bmjopen-2021-054584

DOI
10.1136/bmjopen-2021-054584
Journal article

A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers (vol 76, pg 275, 2022)

Whitfield, J. B., Schwantes-An, T. -H., Darlay, R., Aithal, G. P., Atkinson, S. R., Bataller, R., . . . Seth, D. (2022). A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers (vol 76, pg 275, 2022). JOURNAL OF HEPATOLOGY, 76(5), 1244-1245. doi:10.1016/j.jhep.2022.02.011

DOI
10.1016/j.jhep.2022.02.011
Journal article

Similarity and Consistency Assessment of Three Major Online Drug-Drug Interaction Resources

Kontsioti, E., Maskell, S., Bensalem, A., Dutta, B., & Pirmohamed, M. (2022). Similarity and Consistency Assessment of Three Major Online Drug-Drug Interaction Resources. British Journal of Clinical Pharmacology. doi:10.1111/bcp.15341

DOI
10.1111/bcp.15341
Journal article

DEVELOPMENT OF THE ANTICHOLINERGIC MEDICATION INDEX (ACMI)

Best, K., Alderson, S., Alldred, D., Bonnet, L., Buchan, I., Butters, O., . . . Clegg, A. (2022). DEVELOPMENT OF THE ANTICHOLINERGIC MEDICATION INDEX (ACMI). In AGE AND AGEING Vol. 51. doi:10.1093/ageing/afac035.825

DOI
10.1093/ageing/afac035.825
Conference Paper

T CELL-MEDIATED HYPERSENSITIVITY TO LUMACAFTOR AND IVACAFTOR IN CYSTIC FIBROSIS

Semic-Jusufagic, A., Ogese, M., Edwards, C., Wilkinson, M., Nissenbaum, C., Lee, T., . . . Naisbitt, D. (2022). T CELL-MEDIATED HYPERSENSITIVITY TO LUMACAFTOR AND IVACAFTOR IN CYSTIC FIBROSIS. doi:10.22541/au.164672762.25283352/v1

DOI
10.22541/au.164672762.25283352/v1
Journal article

Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity

Hammond, S., Olsson-Brown, A., Grice, S., Gibson, A., Gardner, J., Castrejon-Flores, J. L., . . . Naisbitt, D. J. (2022). Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity. TOXICOLOGICAL SCIENCES, 186(1), 58-69. doi:10.1093/toxsci/kfab144

DOI
10.1093/toxsci/kfab144
Journal article

Challenges in cardiovascular pharmacogenomics implementation: a viewpoint from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy

Magavern, E. F., Kaski, J. C., Turner, R. M., Drexel, H., Janmohamed, A., Scourfield, A., . . . Caulfield, M. J. (2022). Challenges in cardiovascular pharmacogenomics implementation: a viewpoint from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy. EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY, 8(1), 100-103. doi:10.1093/ehjcvp/pvab063

DOI
10.1093/ehjcvp/pvab063
Journal article

The role of pharmacogenomics in contemporary cardiovascular therapy: a position statement from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy

Magavern, E. F., Kaski, J. C., Turner, R. M., Drexel, H., Janmohamed, A., Scourfield, A., . . . Caulfield, M. J. (2022). The role of pharmacogenomics in contemporary cardiovascular therapy: a position statement from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy. EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY, 8(1), 85-99. doi:10.1093/ehjcvp/pvab018

DOI
10.1093/ehjcvp/pvab018
Journal article

2.15 Pharmacogenomics of Anti-Cancer Drugs

Carr, D. F., Turner, R. M., & Pirmohamed, M. (2022). 2.15 Pharmacogenomics of Anti-Cancer Drugs. In Comprehensive Pharmacology (pp. 311-325). Elsevier. doi:10.1016/b978-0-12-820472-6.00159-6

DOI
10.1016/b978-0-12-820472-6.00159-6
Chapter

Direct oral anticoagulants (DOAC), therapeutic drug monitoring and creatinine clearance

Bula, M., Simms, C., Ablett, C., Ahmed, M., Tempany, J., Tsakiroglou, M., & Pirmohamed, M. (2022). Direct oral anticoagulants (DOAC), therapeutic drug monitoring and creatinine clearance. In EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY Vol. 78 (pp. S145-S146). Retrieved from https://www.webofscience.com/

Conference Paper

Opportunities for de-prescribing in a tertiary UK hospital

Cole, C., Pirmohamed, M., & Tsakiroglou, M. (2022). Opportunities for de-prescribing in a tertiary UK hospital. In EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY Vol. 78 (pp. S67). Retrieved from https://www.webofscience.com/

Conference Paper

Pharmacogenetics of Cutaneous Adverse Drug Reactions

Yip, V. L. M., & Pirmohamed, M. (2022). Pharmacogenetics of Cutaneous Adverse Drug Reactions. In Updates in Clinical Dermatology (pp. 3-34). Springer International Publishing. doi:10.1007/978-3-031-09388-3_1

DOI
10.1007/978-3-031-09388-3_1
Chapter

Pharmacogenomics of Anti-Cancer Drugs

Carr, D. F., Turner, R. M., & Pirmohamed, M. (2022). Pharmacogenomics of Anti-Cancer Drugs. In Comprehensive Pharmacology (pp. 311-325). Elsevier. doi:10.1016/b978-0-12-820472-6.00159-6

DOI
10.1016/b978-0-12-820472-6.00159-6
Chapter

Stable warfarin dose prediction in sub-Saharan African patients: A machine-learning approach and external validation of a clinical dose-initiation algorithm

Asiimwe, I. G., Blockman, M., Cohen, K., Cupido, C., Hutchinson, C., Jacobson, B., . . . Pirmohamed, M. (2022). Stable warfarin dose prediction in sub-Saharan African patients: A machine-learning approach and external validation of a clinical dose-initiation algorithm. CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 11(1), 20-29. doi:10.1002/psp4.12740

DOI
10.1002/psp4.12740
Journal article

The identification of adverse drug reactions in medical hospital admissions: A one month prospective analysis

Osanlou, R., Walker, L., & Pirmohamed, M. (2022). The identification of adverse drug reactions in medical hospital admissions: A one month prospective analysis. In EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY Vol. 78 (pp. S26-S27). Retrieved from https://www.webofscience.com/

Conference Paper

2021

Development of an Adverse Event Reporting Button for a Veterinary Practice Management System

Davies, H., Smyth, S., Noble, P. J., Pinchbeck, G., Diesel, G., Pirmohamed, M., & Killick, D. (2021). Development of an Adverse Event Reporting Button for a Veterinary Practice Management System. In DRUG SAFETY Vol. 44 (pp. 1461-1462). Retrieved from https://www.webofscience.com/

Conference Paper

Corrigendum to 'SJS/TEN 2019: From science to translation' [J. Dermatol. Sci. 98/1 (2020) 2-12].

Chang, W. -C., Abe, R., Anderson, P., Anderson, W., Ardern-Jones, M. R., Beachkofsky, T. M., . . . Carleton, B. C. (2021). Corrigendum to 'SJS/TEN 2019: From science to translation' [J. Dermatol. Sci. 98/1 (2020) 2-12].. J Dermatol Sci, 104(2), 146-147. doi:10.1016/j.jdermsci.2021.09.008

DOI
10.1016/j.jdermsci.2021.09.008
Journal article

Developing and Validating a Clinical Warfarin Dose-Initiation Model for Black-African Patients in South Africa and Uganda (vol 109, pg 1564, 2021)

Asiimwe, I. G., Waitt, C., Sekaggya-Wiltshire, C., Hutchinson, C., Okello, E., Zhang, E. J., . . . Pirmohamed, M. (2021). Developing and Validating a Clinical Warfarin Dose-Initiation Model for Black-African Patients in South Africa and Uganda (vol 109, pg 1564, 2021). CLINICAL PHARMACOLOGY & THERAPEUTICS, 110(5), 1402. doi:10.1002/cpt.2395

DOI
10.1002/cpt.2395
Journal article

SJS/TEN 2019: From science to translation (vol 98, pg 2, 2020)

Chang, W. -C., Abe, R., Anderson, P., Anderson, W., Ardern-Jones, M. R., Beachkofsky, T. M., . . . Carleton, B. C. (2021). SJS/TEN 2019: From science to translation (vol 98, pg 2, 2020). JOURNAL OF DERMATOLOGICAL SCIENCE, 104(2), 146-147. doi:10.1016/j.jdermsci.2021.09.008

DOI
10.1016/j.jdermsci.2021.09.008
Journal article

HLA Allele-Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction.

Jaruthamsophon, K., Thomson, P. J., Sukasem, C., Naisbitt, D. J., & Pirmohamed, M. (2021). HLA Allele-Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction.. Annual review of pharmacology and toxicology, 62, 509-529. doi:10.1146/annurev-pharmtox-052120-014115

DOI
10.1146/annurev-pharmtox-052120-014115
Journal article

Deciphering Adverse Drug Reactions: <i>In Vitro</i> Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01

Ogese, M. O., Lister, A., Gardner, J., Meng, X., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2021). Deciphering Adverse Drug Reactions: <i>In Vitro</i> Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01. TOXICOLOGICAL SCIENCES, 183(1), 139-153. doi:10.1093/toxsci/kfab084

DOI
10.1093/toxsci/kfab084
Journal article

Development of an in vitro model of drug-induced toxic epidermal necrosis

DICKINSON, A. M., AHMED, S., CARR, D. F., OLSSON-BROWN, A., & PIRMOHAMED, M. (n.d.). Development of an in vitro model of drug-induced toxic epidermal necrosis. Unknown Journal, p-174. doi:10.14869/toxpt.48.1.0_p-174

DOI
10.14869/toxpt.48.1.0_p-174
Journal article

AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment: an update to the structured summary of a study protocol for a randomised platform trial letter

Griffiths, G. O., FitzGerald, R., Jaki, T., Corkhill, A., Reynolds, H., Ewings, S., . . . Khoo, S. (2021). AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment: an update to the structured summary of a study protocol for a randomised platform trial letter. TRIALS, 22(1). doi:10.1186/s13063-021-05458-4

DOI
10.1186/s13063-021-05458-4
Journal article

HLA-DQB1 6672G&gt;C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry

Konte, B., Walters, J. T. R., Rujescu, D., Legge, S. E., Pardinas, A. F., Cohen, D., . . . Giegling, I. (2021). HLA-DQB1 6672G&gt;C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry. TRANSLATIONAL PSYCHIATRY, 11(1). doi:10.1038/s41398-021-01322-w

DOI
10.1038/s41398-021-01322-w
Journal article

Warfarin dosing algorithms: A systematic review

Asiimwe, I. G., Zhang, E. J., Osanlou, R., Jorgensen, A. L., & Pirmohamed, M. (2021). Warfarin dosing algorithms: A systematic review. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(4), 1717-1729. doi:10.1111/bcp.14608

DOI
10.1111/bcp.14608
Journal article

A call for the appropriate application of clinical pharmacological principles in the search for safe and efficacious COVID-19 (SARS-COV-2) treatments

Baker, E. H., Gnjidic, D., Kirkpatrick, C. M. J., Pirmohamed, M., Wright, D. F. B., & Zecharia, A. Y. (2021). A call for the appropriate application of clinical pharmacological principles in the search for safe and efficacious COVID-19 (SARS-COV-2) treatments. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(3), 707-711. doi:10.1111/bcp.14416

DOI
10.1111/bcp.14416
Journal article

Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex

Patel, W., Rimmer, L., Smith, M., Moss, L., Smith, M. A., Snodgrass, H. R., . . . Dickens, D. (2021). Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex. MOLECULAR PHARMACEUTICS, 18(1), 113-123. doi:10.1021/acs.molpharmaceut.0c00727

DOI
10.1021/acs.molpharmaceut.0c00727
Journal article

Clinical and pharmacogenetic determinants of tenofovir-induced renal toxicity in HIV positive patients in Zambia

Hamachila, A., Pushpakom, S., Jorgensen, A., & Pirmohamed, M. (2021). Clinical and pharmacogenetic determinants of tenofovir-induced renal toxicity in HIV positive patients in Zambia. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 87 (pp. 4889). Retrieved from https://www.webofscience.com/

Conference Paper

Cutaneous expression of matrix metalloproteinase 9 in SJS/TEN: Putative role in the pathogenesis of epidermal detachment and possible therapeutic target

Carr, D., Olsson-Brown, A., Yip, V., & Pirmohamed, M. (2021). Cutaneous expression of matrix metalloproteinase 9 in SJS/TEN: Putative role in the pathogenesis of epidermal detachment and possible therapeutic target. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 87 (pp. 1621-1622). Retrieved from https://www.webofscience.com/

Conference Paper

Probenecid increases the concentration of 7-chlorokynurenic acid derived from the prodrug 4-chlorokynurenine within the prefrontal cortex

Patel, W., Rimmer, L., Smith, M., Moss, L., Smith, M., Snodgrass, R., . . . Dickens, D. (2021). Probenecid increases the concentration of 7-chlorokynurenic acid derived from the prodrug 4-chlorokynurenine within the prefrontal cortex. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 178 (pp. 463). Retrieved from https://www.webofscience.com/

Conference Paper

2020

Examining the uptake of predictive BRCA testing in the UK; findings and implications

Martin, A., Downing, J., Collins, B., Godman, B., Alfirevic, A., Greenhalgh, L., & Pirmohamed, M. (2020). Examining the uptake of predictive BRCA testing in the UK; findings and implications. European Journal of Human Genetics, 2020. doi:10.1038/s41431-020-00783-9

DOI
10.1038/s41431-020-00783-9
Journal article

Multimorbidity, polypharmacy, and drug-drug-gene interactions following a non-ST elevation acute coronary syndrome: analysis of a multicentre observational study

Turner, R. M., de Koning, E. M., Fontana, V., Thompson, A., & Pirmohamed, M. (2020). Multimorbidity, polypharmacy, and drug-drug-gene interactions following a non-ST elevation acute coronary syndrome: analysis of a multicentre observational study. BMC MEDICINE, 18(1). doi:10.1186/s12916-020-01827-z

DOI
10.1186/s12916-020-01827-z
Journal article

Safety perspectives on presently considered drugs for the treatment of COVID‐19

Penman, S. L., Kiy, R. T., Jensen, R. L., Beoku‐Betts, C., Alfirevic, A., Back, D., . . . Chadwick, A. E. (n.d.). Safety perspectives on presently considered drugs for the treatment of COVID‐19. British Journal of Pharmacology. doi:10.1111/bph.15204

DOI
10.1111/bph.15204
Journal article

Beyond corticosteroids for the management of patients with cutaneous immune-related adverse events secondary to immune checkpoint inhibitors

Yip, V., Olsson-Brown, A., Carr, D., Pirmohamed, M., & Hindle, E. (2020). Beyond corticosteroids for the management of patients with cutaneous immune-related adverse events secondary to immune checkpoint inhibitors. In BRITISH JOURNAL OF DERMATOLOGY Vol. 183 (pp. 136). Retrieved from https://www.webofscience.com/

Conference Paper

Obesity, Diabetes, Coffee, Tea, and Cannabis Use Alter Risk for Alcohol-Related Cirrhosis in 2 Large Cohorts of High-Risk Drinkers.

Whitfield, J. B., Masson, S., Liangpunsakul, S., Mueller, S., Aithal, G. P., Eyer, F., . . . GenomALC Consortium. (2020). Obesity, Diabetes, Coffee, Tea, and Cannabis Use Alter Risk for Alcohol-Related Cirrhosis in 2 Large Cohorts of High-Risk Drinkers.. The American journal of gastroenterology. doi:10.14309/ajg.0000000000000833

DOI
10.14309/ajg.0000000000000833
Journal article

Study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost-effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of standard and new antiepileptic drugs (SANAD-II).

Balabanova, S., Taylor, C., Sills, G., Burnside, G., Plumpton, C., Smith, P. E. M., . . . Marson, A. G. (2020). Study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost-effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of standard and new antiepileptic drugs (SANAD-II).. BMJ open, 10(8), e040635. doi:10.1136/bmjopen-2020-040635

DOI
10.1136/bmjopen-2020-040635
Journal article

Generating evidence for precision medicine: considerations made by the Ubiquitous Pharmacogenomics Consortium when designing and operationalizing the PREPARE study

van der Wouden, C. H., Bohringer, S., Cecchin, E., Cheung, K. -C., Lucia Davila-Fajardo, C., Deneer, V. H. M., . . . Consor, U. P. (2020). Generating evidence for precision medicine: considerations made by the Ubiquitous Pharmacogenomics Consortium when designing and operationalizing the PREPARE study. Pharmacogenetics and Genomics, 30(6), 131-144. doi:10.1097/FPC.0000000000000405

DOI
10.1097/FPC.0000000000000405
Journal article

Molecular medicine and genetics

Mirza, N. S., & Pirmohamed, M. (2020). Molecular medicine and genetics. In Medicine for MRCP (pp. 37-56). Oxford University Press. doi:10.1093/med/9780198779506.003.0002

DOI
10.1093/med/9780198779506.003.0002
Chapter

Genetic Association of Co‐Trimoxazole‐Induced Severe Cutaneous Adverse Reactions Is Phenotype‐Specific: HLA Class I Genotypes and Haplotypes

Sukasem, C., Pratoomwun, J., Satapornpong, P., Klaewsongkram, J., Rerkpattanapipat, T., Rerknimitr, P., . . . Pirmohamed, M. (2020). Genetic Association of Co‐Trimoxazole‐Induced Severe Cutaneous Adverse Reactions Is Phenotype‐Specific: HLA Class I Genotypes and Haplotypes. Clinical Pharmacology and Therapeutics. doi:10.1002/cpt.1915

DOI
10.1002/cpt.1915
Journal article

Has the introduction of direct oral anticoagulants (DOACs) in England increased emergency admissions for bleeding conditions? A longitudinal ecological study

Alfirevic, A., Downing, J., Daras, K., Comerford, T., Pirmohamed, M., & Barr, B. (2020). Has the introduction of direct oral anticoagulants (DOACs) in England increased emergency admissions for bleeding conditions? A longitudinal ecological study. BMJ Open, 10(5). doi:10.1136/bmjopen-2019-033357

DOI
10.1136/bmjopen-2019-033357
Journal article

TAILoR (TelmisArtan and InsuLin Resistance in Human Immunodeficiency Virus [HIV]): An Adaptive-design, Dose-ranging Phase IIb Randomized Trial of Telmisartan for the Reduction of Insulin Resistance in HIV-positive Individuals on Combination Antiretroviral Therapy

Pushpakom, S. P., Kolamunnage-Dona, R., Taylor, C., Foster, T., Spowart, C., Garcia-Finana, M., . . . Pirmohamed, M. (n.d.). TAILoR (TelmisArtan and InsuLin Resistance in Human Immunodeficiency Virus [HIV]): An Adaptive-design, Dose-ranging Phase IIb Randomized Trial of Telmisartan for the Reduction of Insulin Resistance in HIV-positive Individuals on Combination Antiretroviral Therapy. Clinical Infectious Diseases. doi:10.1093/cid/ciz589

DOI
10.1093/cid/ciz589
Journal article

Su1185 IMMUNE CHECKPOINT INHIBITOR-RELATED COLITIS ASSESSMENT AND PROGNOSIS: CAN UCEIS, MAYO AND NANCY INDEX SCORING POINT THE WAY?

Cheung, V. T., Gupta, T., Olsson-Brown, A. C., Subramanian, S., Sasson, S. C., Heseltine, J., . . . Brain, O. (2020). Su1185 IMMUNE CHECKPOINT INHIBITOR-RELATED COLITIS ASSESSMENT AND PROGNOSIS: CAN UCEIS, MAYO AND NANCY INDEX SCORING POINT THE WAY?. Gastroenterology, 158(6). doi:10.1016/s0016-5085(20)32033-3

DOI
10.1016/s0016-5085(20)32033-3
Journal article

A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis (vol 10, 1796, 2020)

McWilliam, S. J., Rosala-Hallas, A., Jones, A. P., Shaw, V., Greenhalf, W., Jaki, T., . . . Pirmohamed, M. (2020). A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis (vol 10, 1796, 2020). SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-61783-9

DOI
10.1038/s41598-020-61783-9
Journal article

Characterization of Circulating Clostridium difficile Strains, Host Response and Intestinal Microbiome in Hospitalized Children With Diarrhea

Lees, E. A., Carrol, E. D., Ellaby, N. A. F., Roberts, P., Corless, C. E., Lenzi, L., . . . Pirmohamed, M. (2020). Characterization of Circulating Clostridium difficile Strains, Host Response and Intestinal Microbiome in Hospitalized Children With Diarrhea. The Pediatric infectious disease journal, 39(3), 221-228. doi:10.1097/inf.0000000000002559

DOI
10.1097/inf.0000000000002559
Journal article

HLA-DQB1 6672 G&gt;C is associated with the risk of clozapine-induced agranulocytosis in individuals of European ancestry

Konte, B., Walters, J. T., Giegling, I., Legge, S., Pardina, A. F., Cohen, D., . . . Rujescu, D. (2020). HLA-DQB1 6672 G&gt;C is associated with the risk of clozapine-induced agranulocytosis in individuals of European ancestry. In PHARMACOPSYCHIATRY Vol. 53 (pp. 88). doi:10.1055/s-0039-3403016

DOI
10.1055/s-0039-3403016
Conference Paper

A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis.

McWilliam, S. J., Rosala-Hallas, A., Jones, A. P., Shaw, V., Greenhalf, W., Jaki, T., . . . Pirmohamed, M. (2020). A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis.. Scientific reports, 10(1). doi:10.1038/s41598-020-58790-1

DOI
10.1038/s41598-020-58790-1
Journal article

P272 Immune checkpoint inhibitor-related colitis assessment and prognosis: can inflammatory bowel disease scoring point the way?

Cheung, V. T. F., Gupta, T., Olsson-Brown, A., Subramanian, S., Sasson, S. C., Heseltine, J., . . . Brain, O. (2020). P272 Immune checkpoint inhibitor-related colitis assessment and prognosis: can inflammatory bowel disease scoring point the way?. Journal of Crohn's and Colitis, 14(Supplement_1), S286-S288. doi:10.1093/ecco-jcc/jjz203.401

DOI
10.1093/ecco-jcc/jjz203.401
Journal article

IMMUNE CHECKPOINT INHIBITOR-RELATED COLITIS ASSESSMENT AND PROGNOSIS: CAN UCEIS, MAYO AND NANCY INDEX SCORING POINT THE WAY?

Cheung, V. T., Gupta, T., Olsson-Brown, A. C., Subramanian, S., Sasson, S. C., Heseltine, J., . . . Brain, O. (2020). IMMUNE CHECKPOINT INHIBITOR-RELATED COLITIS ASSESSMENT AND PROGNOSIS: CAN UCEIS, MAYO AND NANCY INDEX SCORING POINT THE WAY?. In GASTROENTEROLOGY Vol. 158 (pp. S535-S536). Retrieved from https://www.webofscience.com/

Conference Paper

Investigating the clinical factors and comedications associated with circulating levels of atorvastatin and its major metabolites in secondary prevention

Turner, R. M., Fontana, V., FitzGerald, R., Morris, A. P., & Pirmohamed, M. (2020). Investigating the clinical factors and comedications associated with circulating levels of atorvastatin and its major metabolites in secondary prevention. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 86(1), 62-74. doi:10.1111/bcp.14133

DOI
10.1111/bcp.14133
Journal article

S1.1 - Warfarin: A paradigm for individualized dosing

Pirmohamed, M. (2020). S1.1 - Warfarin: A paradigm for individualized dosing. Drug Metabolism and Pharmacokinetics, 35(1), S6. doi:10.1016/j.dmpk.2020.04.288

DOI
10.1016/j.dmpk.2020.04.288
Journal article

The antidepressant AV-101 is a substrate for LAT1 (SLC7A5) at the blood-brain barrier

Patel, W., Smith, M., Snodgrass, R., Pirmohamed, M., Alfirevic, A., & Dickens, D. (2020). The antidepressant AV-101 is a substrate for LAT1 (SLC7A5) at the blood-brain barrier. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 177 (pp. 2621-2622). Retrieved from https://www.webofscience.com/

Conference Paper

WARFARIN: A PARADIGM FOR INDIVIDUALIZED DOSING

Pirmohamed, M. (2020). WARFARIN: A PARADIGM FOR INDIVIDUALIZED DOSING. In DRUG METABOLISM AND PHARMACOKINETICS Vol. 35 (pp. S6). Retrieved from https://www.webofscience.com/

Conference Paper

2019

Genomewide Association Study of Statin‐Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink

Carr, D. (2019). Genomewide Association Study of Statin‐Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink. Clinical Pharmacology and Therapeutics, 106(6), 1353-1361. doi:10.1002/cpt.1557

DOI
10.1002/cpt.1557
Journal article

Prescribing in liver disease

Doogue, M., Martin, J., Miners, J., & Somogyi, A. (2009). Prescribing in liver disease. AUSTRALIAN PRESCRIBER, 32(5), 120. Retrieved from https://www.webofscience.com/

Journal article

Implementation of pharmacogenomics in the clinic

Pirmohamed, M. (2018). Implementation of pharmacogenomics in the clinic. In EUROPEAN JOURNAL OF HUMAN GENETICS Vol. 26 (pp. 31). Retrieved from https://www.webofscience.com/

Conference Paper

Adverse drug reaction causality assessment tools for drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: room for improvement (vol 75, pg 1135, 2019)

Goldman, J. L., Chung, W. -H., Lee, B. R., Chen, C. -B., Lu, C. -W., Hoetzenecker, W., . . . Pirmohamed, M. (2019). Adverse drug reaction causality assessment tools for drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: room for improvement (vol 75, pg 1135, 2019). EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 75(9), 1331. doi:10.1007/s00228-019-02710-4

DOI
10.1007/s00228-019-02710-4
Journal article

Trends in <i>BRCA</i> testing and socioeconomic deprivation

Martin, A. P., Pedra, G., Downing, J., Collins, B., Godman, B., Alfirevic, A., . . . Greenhalgh, K. L. (2019). Trends in <i>BRCA</i> testing and socioeconomic deprivation. EUROPEAN JOURNAL OF HUMAN GENETICS, 27(9), 1351-1360. doi:10.1038/s41431-019-0424-3

DOI
10.1038/s41431-019-0424-3
Journal article

ADVERSE DRUG REACTION CAUSALITY ASSESSMENT TOOLS FOR DRUG-INDUCED STEVENS-JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS: ROOM FOR IMPROVEMENT.

Goldman, J. L., Chung, W. -H., Lee, B. R., Chen, C. -B., Lu, C. -W., Hoetzenecker, W., . . . Pirmohamed, M. (2019). Adverse drug reaction causality assessment tools for drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: room for improvement. In EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY Vol. 75 (pp. 1135-1141). doi:10.1007/s00228-019-02670-9

Conference Paper

Cutaneous toxicity from immune checkpoint inhibitors: experience from a specialist dermatology unit

Yip, V., Hindle, E., Olsson-Brown, A., & Pirmohamed, M. (2019). Cutaneous toxicity from immune checkpoint inhibitors: experience from a specialist dermatology unit. In BRITISH JOURNAL OF DERMATOLOGY Vol. 181 (pp. 69). Retrieved from https://www.webofscience.com/

Conference Paper

Nilotinib-induced metabolic dysfunction: insights from a translational study using in vitro adipocyte models and patient cohorts

Sadiq, S., Owen, E., Foster, T., Knight, K., Wang, L., Pirmohamed, M., . . . Pushpakom, S. (2019). Nilotinib-induced metabolic dysfunction: insights from a translational study using in vitro adipocyte models and patient cohorts. Leukemia, 33, 1810-1814. doi:10.1038/s41375-018-0337-0

DOI
10.1038/s41375-018-0337-0
Journal article

Serum and blister-fluid elevation and decreased epidermal content of high-mobility group box 1 protein in drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis

Carr, D. F., Wang, C. -W., Bellon, T., Ressel, L., Nwikue, G., Shrivastava, V., . . . Pirmohamed, M. (2019). Serum and blister-fluid elevation and decreased epidermal content of high-mobility group box 1 protein in drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis. BRITISH JOURNAL OF DERMATOLOGY, 181(1), 166-174. doi:10.1111/bjd.17610

DOI
10.1111/bjd.17610
Journal article

ALCOHOL RELATED BRAIN INJURY IN ALCOHOL USE DISORDER PATIENTS ATTENDING A UK SECONDARY CARE HOSPITAL

Richardson, P., Pirmohamed, M., Owens, L., & Thompson, A. (2019). ALCOHOL RELATED BRAIN INJURY IN ALCOHOL USE DISORDER PATIENTS ATTENDING A UK SECONDARY CARE HOSPITAL. In ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Vol. 43 (pp. 186A). Retrieved from https://www.webofscience.com/

Conference Paper

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy (Retraction of Vol 127, Pg 2118, 2017)

Walker, L. E., Frigerio, F., Ravizza, T., Ricci, E., Tse, K., Jenkins, R. E., . . . Pirmohamed, M. (2019). Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy (Retraction of Vol 127, Pg 2118, 2017). JOURNAL OF CLINICAL INVESTIGATION, 129(5), 2166. doi:10.1172/JCI129285

DOI
10.1172/JCI129285
Journal article

What are the social predictors of accident and emergency attendance in disadvantaged neighbourhoods? Results from a cross-sectional household health survey in the north west of England

Giebel, C., McIntyre, J. C., Daras, K., Gabbay, M., Downing, J., Pirmohamed, M., . . . Barr, B. (2019). What are the social predictors of accident and emergency attendance in disadvantaged neighbourhoods? Results from a cross-sectional household health survey in the north west of England. BMJ Open, 9(1). doi:10.1136/bmjopen-2018-022820

DOI
10.1136/bmjopen-2018-022820
Journal article

CAN GENOTYPING PREDICT RISK OF ALCOHOL-RELATED CIRRHOSIS IN HIGH-RISK DRINKERS?

Whitfield, J., Schwantes-An, T. -H., Cordell, H. J., Darlay, R., Masson, S., Liangpunsakul, S., . . . Seth, D. (2019). CAN GENOTYPING PREDICT RISK OF ALCOHOL-RELATED CIRRHOSIS IN HIGH-RISK DRINKERS?. In HEPATOLOGY Vol. 70 (pp. 171A-172A). Retrieved from https://www.webofscience.com/

Conference Paper

CD8+Tcell integrin α4β7expression: a potential predictor of severity and steroid sensitivity in checkpoint inhibitor induced colitis

Olsson-Brown, A., Sacco, J., Olsson-Brown, A., Olsson-Brown, A., Cachinho, S., Jolly, C., . . . Pirmohamed, M. (2019). CD8+Tcell integrin α4β7expression: a potential predictor of severity and steroid sensitivity in checkpoint inhibitor induced colitis. In JOURNAL FOR IMMUNOTHERAPY OF CANCER Vol. 7. Retrieved from https://www.webofscience.com/

Conference Paper

Cutaneous toxicity from immune checkpoint inhibitors: experience from a specialist dermatology unit

Yip, V., Hindle, E., Olsson-Brown, A., & Pirmohamed, M. (2019). Cutaneous toxicity from immune checkpoint inhibitors: experience from a specialist dermatology unit. In BRITISH JOURNAL OF DERMATOLOGY Vol. 181 (pp. 136). Retrieved from https://www.webofscience.com/

Conference Paper

Drug-induced liver injury associated with Antituberculosis and/or antiretroviral therapy: A case series from a prospective registry in the Western cape, South Africa

Gunter, H. M., Allie, S., Stewart, A., Pirmohamed, M., & Cohen, K. (2019). Drug-induced liver injury associated with Antituberculosis and/or antiretroviral therapy: A case series from a prospective registry in the Western cape, South Africa. In PHARMACOEPIDEMIOLOGY AND DRUG SAFETY Vol. 28 (pp. 576-577). Retrieved from https://www.webofscience.com/

Conference Paper

HLA-DQB1 6672G&gt;C INFLUENCES THE RISK OF CLOZAPINE-INDUCED AGRANULOCYTOSIS IN INDIVIDUALS OF EUROPEAN ANCESTRY

Konte, B., Walters, J., Giegling, I., Legge, S., Cohen, D., Pirmohamed, M., . . . Rujescu, D. (2019). HLA-DQB1 6672G&gt;C INFLUENCES THE RISK OF CLOZAPINE-INDUCED AGRANULOCYTOSIS IN INDIVIDUALS OF EUROPEAN ANCESTRY. In EUROPEAN NEUROPSYCHOPHARMACOLOGY Vol. 29 (pp. S866). doi:10.1016/j.euroneuro.2017.08.154

DOI
10.1016/j.euroneuro.2017.08.154
Conference Paper

META-ANALYSIS OF CLOZAPINE-ASSOCIATED NEUTROPENIA AND AGRANULOCYTOSIS

Konte, B., Walters, J. T., Giegling, I., Legge, S., Pardinas, A. F., Cohen, D., . . . Rujescu, D. (2019). META-ANALYSIS OF CLOZAPINE-ASSOCIATED NEUTROPENIA AND AGRANULOCYTOSIS. In EUROPEAN NEUROPSYCHOPHARMACOLOGY Vol. 29 (pp. 1320-1321). doi:10.1016/j.euroneuro.2018.08.466

DOI
10.1016/j.euroneuro.2018.08.466
Conference Paper

Precision Medicine

Pirmohamed, M. (2019). Precision Medicine. In JOURNAL OF PATHOLOGY Vol. 248 (pp. S4). Retrieved from https://www.webofscience.com/

Conference Paper

REPLICATION OF TWO INDEPENDENT LOCI IN HLA-DQB1 AND HLA-B CONTRIBUTING TO THE RISK OF CLOZAPINE-INDUCED AGRANULOCYTOSIS

Konte, B., Giegling, I., Legge, S., Cohen, D., Pirmohamed, M., Tiihonen, J., . . . Rujescu, D. (2019). REPLICATION OF TWO INDEPENDENT LOCI IN HLA-DQB1 AND HLA-B CONTRIBUTING TO THE RISK OF CLOZAPINE-INDUCED AGRANULOCYTOSIS. In EUROPEAN NEUROPSYCHOPHARMACOLOGY Vol. 29 (pp. S939). doi:10.1016/j.euroneuro.2017.08.282

DOI
10.1016/j.euroneuro.2017.08.282
Conference Paper

TRENDS AND UPTAKE OF PREDICTIVE <i>BRCA</i> TESTING

Martin, A., Pedra, G., Downing, J., Godman, B., Alfirevic, A., Greenhalgh, K. L., & Pirmohamed, M. (2019). TRENDS AND UPTAKE OF PREDICTIVE <i>BRCA</i> TESTING. In VALUE IN HEALTH Vol. 22 (pp. S428). Retrieved from https://www.webofscience.com/

Conference Paper

2018

MECHANISMS OF CHEMOTHERAPY-INDUCED DIARRHOEA

French, S., Davies, A., & Pirmohamed, M. (2018). MECHANISMS OF CHEMOTHERAPY-INDUCED DIARRHOEA. In GUT Vol. 67 (pp. A159). doi:10.1136/gutjnl-2018-BSGAbstracts.315

DOI
10.1136/gutjnl-2018-BSGAbstracts.315
Conference Paper

Identification of a novel locus associated with asthma treatment response with inhaled corticosteroids in African-admixed children

Hernandez-Pacheco, N., Farzan, N., Vijverberg, S., Francis, B., Schieck, M., Pirmohamed, M., . . . Pino-Yanes, M. (2018). Identification of a novel locus associated with asthma treatment response with inhaled corticosteroids in African-admixed children. In EUROPEAN JOURNAL OF HUMAN GENETICS Vol. 26 (pp. 693-694). Retrieved from https://www.webofscience.com/

Conference Paper

Trastuzumab uptake in HER2-positive breast cancer patients: a systematic review and meta-analysis of observational studies

Martin, A. P., Downing, J., Cochrane, M., Collins, B., Francis, B., Haycox, A., . . . Pirmohamed, M. (2018). Trastuzumab uptake in HER2-positive breast cancer patients: a systematic review and meta-analysis of observational studies. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 130, 92-107. doi:10.1016/j.critrevonc.2018.07.012

DOI
10.1016/j.critrevonc.2018.07.012
Journal article

Development, validation and application of a novel HPLC-MS/MS method for the quantification of atorvastatin, bisoprolol and clopidogrel in a large cardiovascular patient cohort.

Turner, R. M., Fontana, V., Bayliss, M., Whalley, S., Castelazo, A. S., & Pirmohamed, M. (2018). Development, validation and application of a novel HPLC-MS/MS method for the quantification of atorvastatin, bisoprolol and clopidogrel in a large cardiovascular patient cohort. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 159, 272-281. doi:10.1016/j.jpba.2018.06.062

DOI
10.1016/j.jpba.2018.06.062
Journal article

New uses for old drugs

Pantziarka, P., Pirmohamed, M., & Mirza, N. (2018). New uses for old drugs. BMJ-BRITISH MEDICAL JOURNAL, 361. doi:10.1136/bmj.k2701

DOI
10.1136/bmj.k2701
Journal article

WITHDRAWN: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers.

Francis, B., Clarke, J. I., Walker, L. E., Brillant, N., Jorgensen, A. L., Park, B. K., . . . Antoine, D. J. (2018). WITHDRAWN: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers.. Journal of hepatology, S0168-8278(18)32042-7. doi:10.1016/j.jhep.2018.04.024

DOI
10.1016/j.jhep.2018.04.024
Journal article

Clinical Pharmacogenetics Implementation Consortium Guideline for <i>HLA</i> Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update

Phillips, E. J., Sukasem, C., Whirl-Carrillo, M., Mueller, D. J., Dunnenberger, H. M., Chantratita, W., . . . Pirmohamed, M. (2018). Clinical Pharmacogenetics Implementation Consortium Guideline for <i>HLA</i> Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update. CLINICAL PHARMACOLOGY & THERAPEUTICS, 103(4), 574-581. doi:10.1002/cpt.1004

DOI
10.1002/cpt.1004
Journal article

Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity

Usui, T., Faulkner, L., Farrell, J., French, N. S., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2018). Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity. CHEMICAL RESEARCH IN TOXICOLOGY, 31(3), 165-167. doi:10.1021/acs.chemrestox.8b00030

DOI
10.1021/acs.chemrestox.8b00030
Journal article

Direct oral anticoagulants versus warfarin: is new always better than the old? (vol 5, e000712, 2018)

Burn, J., & Pirmohamed, M. (2018). Direct oral anticoagulants versus warfarin: is new always better than the old? (vol 5, e000712, 2018). OPEN HEART, 5(1). doi:10.1136/openhrt-2017-000712corr1

DOI
10.1136/openhrt-2017-000712corr1
Journal article

The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017)

Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2018). The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1951. doi:10.4049/jimmunol.1800019

DOI
10.4049/jimmunol.1800019
Journal article

Two distinct clinical trajectories of inflammatory thyroiditis evoked by checkpoint blockade in malignant melanoma.

Olsson-Brown, A. C., Lord, R., Sacco, J. J., Coles, M. C., Wagg, J., & Pirmohamed, M. (2018). Two distinct clinical trajectories of inflammatory thyroiditis evoked by checkpoint blockade in malignant melanoma.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 36. doi:10.1200/JCO.2018.36.5_suppl.131

DOI
10.1200/JCO.2018.36.5_suppl.131
Conference Paper

A Genome-Wide Association Study of Methotrexate-Pneumonitis in Rheumatoid Arthritis: Results from the Pneumonitis Study Consortium

Bluett, J., Owen, S. -A., Massey, J., Plant, D., Pirmohamed, M., Verstappen, S. M. M., & Barton, A. (2018). A Genome-Wide Association Study of Methotrexate-Pneumonitis in Rheumatoid Arthritis: Results from the Pneumonitis Study Consortium. In ARTHRITIS & RHEUMATOLOGY Vol. 68. Retrieved from http://gateway.webofknowledge.com/

Conference Paper

Pharmacogenetics and Pharmacogenomics in Cardiovascular Medicine and Surgery

Turner, R. M., & Pirmohamed, S. M. (2018). Pharmacogenetics and Pharmacogenomics in Cardiovascular Medicine and Surgery. In Cardiovascular Genetics and Genomics (pp. 119-172). Springer International Publishing. doi:10.1007/978-3-319-66114-8_5

DOI
10.1007/978-3-319-66114-8_5
Chapter

Effects of Common Antiepileptic Drugs on Biomarkers of Oxidative Stress in a Human Neuroblastoma Cell Line

Al-Mosawi, R., Marson, A., Pirmohamed, M., & Sills, G. (2018). Effects of Common Antiepileptic Drugs on Biomarkers of Oxidative Stress in a Human Neuroblastoma Cell Line. In EPILEPSIA Vol. 59 (pp. S39). Retrieved from https://www.webofscience.com/

Conference Paper

IMPLEMENTING PRE-EMPTIVE PHARMACOGENOMIC TESTING FOR A PANEL OF PHARMACOGENES IN THE PREPARE STUDY (U-PGx CONSORTIUM): RESULTS FROM THE FIRST 1,000 PATIENTS.

van der Wouden, C. H., Davila-Fajardo, C., Dolzan, V., Patrinos, G. P., Pirmohamed, M., Sunder-Plassmann, G., . . . Guchelaar, H. -J. (2018). IMPLEMENTING PRE-EMPTIVE PHARMACOGENOMIC TESTING FOR A PANEL OF PHARMACOGENES IN THE PREPARE STUDY (U-PGx CONSORTIUM): RESULTS FROM THE FIRST 1,000 PATIENTS.. In CLINICAL PHARMACOLOGY & THERAPEUTICS Vol. 103 (pp. S13). Retrieved from https://www.webofscience.com/

Conference Paper

Identification of a PTPN22 Missense Variant As a General Genetic Risk Factor for Drug-Induced Liver Injury

Watkins, P. B., Nicoletti, P., Cirulli, E., Abramson, K., Andrade, R. J., Bjornsson, E., . . . Aithal, G. P. (2018). Identification of a PTPN22 Missense Variant As a General Genetic Risk Factor for Drug-Induced Liver Injury. In HEPATOLOGY Vol. 68 (pp. 25A). Retrieved from https://www.webofscience.com/

Conference Paper

Pharmacogenetics of Adverse Drug Reactions

Osanlou, O., Pirmohamed, M., & Daly, A. K. (2018). Pharmacogenetics of Adverse Drug Reactions. In PHARMACOGENETICS (Vol. 83, pp. 155-190). doi:10.1016/bs.apha.2018.03.002

DOI
10.1016/bs.apha.2018.03.002
Chapter

The Prescribable Drugs with Efficacy in Experimental Epilepsies (PDE3) Database for Drug Repurposing Research in Epilepsy

Sivapalarajah, S., Krishnakumar, M., Bickerstaffe, H., Chan, Y., Clarkson, J., Hampden-Martin, A., . . . Mirza, N. (2018). The Prescribable Drugs with Efficacy in Experimental Epilepsies (PDE3) Database for Drug Repurposing Research in Epilepsy. In EPILEPSIA Vol. 59 (pp. S70-S71). Retrieved from https://www.webofscience.com/

Conference Paper

The unexpected challenges of immunotherapy

Olsson-Brown, A. C., Guinan, T. J., Mckay, M., Chow, S., Lord, R., Pirmohamed, M., & Sacco, J. J. (2018). The unexpected challenges of immunotherapy. In ANNALS OF ONCOLOGY Vol. 29 (pp. 20). Retrieved from https://www.webofscience.com/

Conference Paper

2017

HLA-A 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome-wide association study.

Bluett, J., Owen, S. -A., Massey, J., Alfirevic, A., Pirmohamed, M., Plant, D., . . . Barton, A. (2017). HLA-A 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome-wide association study. ANNALS OF THE RHEUMATIC DISEASES, 76(12). doi:10.1136/annrheumdis-2017-211512

DOI
10.1136/annrheumdis-2017-211512
Journal article

The molecular genetics of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis

Cliff, J., Jorgensen, A. L., Lord, R., Azam, F., Cossar, L., Carr, D. F., & Pirmohamed, M. (2017). The molecular genetics of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 120, 127-140. doi:10.1016/j.critrevonc.2017.09.009

DOI
10.1016/j.critrevonc.2017.09.009
Journal article

Mechanisms of Chemotherapy-Induced Diarrhoea

French, S., Davies, A., & Pirmohamed, M. (2017). Mechanisms of Chemotherapy-Induced Diarrhoea. In DRUG SAFETY Vol. 40 (pp. 1025-1026). Retrieved from https://www.webofscience.com/

Conference Paper

Beyond co-occurrence-based ADR detection from Social Media

Bollegala, D., Maskell, S., & Pirmohamed, M. (2017). Beyond co-occurrence-based ADR detection from Social Media. Poster session presented at the meeting of Unknown Conference. Retrieved from https://www.webofscience.com/

Poster

Whole exome sequencing in individuals with statin-induced myopathy

Bloch, K. M., Carr, D., Pirmohamed, M., Morris, A., Maroteau, C., Eriksson, N., . . . Alfirevic, A. (2017). Whole exome sequencing in individuals with statin-induced myopathy. In DRUG SAFETY Vol. 40 (pp. 1026). Retrieved from https://www.webofscience.com/

Conference Paper

Multiple HLA B*57 alleles, sharing the amino acid residue Valine(97), are associated with drug-induced liver injury due to flucloxacillin in a European population.

Nicoletti, P., Aithal, G. P., Coulthard, S., Andrade, R., Einar, B. S., Dillon, J., . . . Daly, A. K. (2017). Multiple HLA B*57 alleles, sharing the amino acid residue Valine<SUP>97</SUP>, are associated with drug-induced liver injury due to flucloxacillin in a European population.. In HEPATOLOGY Vol. 66 (pp. 25A-26A). Retrieved from https://www.webofscience.com/

Conference Paper

Genome-wide association study of asthma exacerbations in European children treated with inhaled corticosteroids

Vijverberg, S. J. H., Hernandez-Pacheco, N., Farzan, N., Francis, B., Flores, C., Schieck, M., . . . Maitland-Van der Zee, A. -H. (2017). Genome-wide association study of asthma exacerbations in European children treated with inhaled corticosteroids. In EUROPEAN RESPIRATORY JOURNAL Vol. 50. doi:10.1183/1393003.congress-2017.PA1817

DOI
10.1183/1393003.congress-2017.PA1817
Conference Paper

THE PROTEKT STUDY - A PHASE IIA, RANDOMISED, CONTROLLED, OPEN-LABEL TRIAL OF ROSUVASTATIN FOR THE PREVENTION OF AMINOGLYCOSIDE-INDUCED KIDNEY TOXICITY IN CHILDREN WITH CYSTIC FIBROSIS

McWilliam, S. J., Antoine, D. J., Rosala-Hallas, A., Jones, A., MacLean, C., Prayle, A., . . . Pirmohamed, M. (2017). THE PROTEKT STUDY - A PHASE IIA, RANDOMISED, CONTROLLED, OPEN-LABEL TRIAL OF ROSUVASTATIN FOR THE PREVENTION OF AMINOGLYCOSIDE-INDUCED KIDNEY TOXICITY IN CHILDREN WITH CYSTIC FIBROSIS. In PEDIATRIC PULMONOLOGY Vol. 52 (pp. S353). Indiana Convention Center, Indianapolis, Indiana. doi:10.1002/ppul.23840

DOI
10.1002/ppul.23840
Conference Paper

17q21 gene variation increases the risk of exacerbations in asthmatic children treated with inhaled corticosteroids: A meta-analysis in the multi-ethnic pica consortium

Farzan, N., Vijverberg, S. J., Hernandez-Pacheco, N., Berce, V., Burchard, E. G., Canino, G., . . . Maitland-Van der Zee, A. H. (2017). 17q21 gene variation increases the risk of exacerbations in asthmatic children treated with inhaled corticosteroids: A meta-analysis in the multi-ethnic pica consortium. In ALLERGY Vol. 72 (pp. 269-270). Retrieved from https://www.webofscience.com/

Conference Paper

A PROSPECTIVE OPEN COHORT STUDY EXAMINING THE EFFECTIVENESS OF BACLOFEN IN AUD PATIENTS ATTENDING A JOINT LIVER AND ALCOHOL TREATMENT CLINIC

Owens, L., Thompson, A., Rose, A., Pirmohamed, M., Gilmore, I., & Richardson, P. (2016). A PROSPECTIVE OPEN COHORT STUDY EXAMINING THE EFFECTIVENESS OF BACLOFEN IN AUD PATIENTS ATTENDING A JOINT LIVER AND ALCOHOL TREATMENT CLINIC. In ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Vol. 40 (pp. 275A). Retrieved from https://www.webofscience.com/

Conference Paper

A prospective cohort study examining the effectiveness of baclofen in the maintenance of abstinence in alcohol use disorder patients attending a joint liver and alcohol treatment clinic

Owens, L., Thompson, A., Rose, A., Gilmore, I., Pirmohamed, M., & Richardson, P. (2017). A prospective cohort study examining the effectiveness of baclofen in the maintenance of abstinence in alcohol use disorder patients attending a joint liver and alcohol treatment clinic. Alcohol, 62, 11-15. doi:10.1016/j.alcohol.2016.12.005

DOI
10.1016/j.alcohol.2016.12.005
Journal article

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients

Yip, V. L. M., Meng, X., Maggs, J. L., Jenkins, R., Marlot, P., Marson, A., . . . Pirmohamed, M. (2017). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients. Chemical Research in Toxicology, 30(7), 1419-1435. doi:10.1021/acs.chemrestox.7b00063

DOI
10.1021/acs.chemrestox.7b00063
Journal article

Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium (vol 101, pg 341, 2017)

van der Wouden, C. H., Cambon-Thomsen, A., Cecchin, E., Cheung, K. C., Davila-Fajardo, C. L., Deneer, V. H., . . . Guchelaar, H. -J. (2017). Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium (vol 101, pg 341, 2017). CLINICAL PHARMACOLOGY & THERAPEUTICS, 102(1), 152. doi:10.1002/cpt.725

DOI
10.1002/cpt.725
Journal article

Stroke Pharmacogenetics

Walker, L. E., Stewart, A., & Pirmohamed, S. M. (2017). Stroke Pharmacogenetics. In P. Sharma, & J. F. Meschia (Eds.), Stroke Genetics (pp. 327-410). Springer. doi:10.1007/978-3-319-56210-0_17

DOI
10.1007/978-3-319-56210-0_17
Chapter

Causality Patterns for Detecting Adverse Drug Reactions From Social Media: Text Mining Approach (Preprint)

Bollegala, D., Maskell, S., Sloane, R., Hajne, J., & Pirmohamed, M. (2017). Causality Patterns for Detecting Adverse Drug Reactions From Social Media: Text Mining Approach (Preprint). doi:10.2196/preprints.8214

DOI
10.2196/preprints.8214
Journal article

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Standard Reporting and Evaluation Guidelines: Results of a National Institutes of Health Working Group.

Maverakis, E., Wang, E. A., Shinkai, K., Mahasirimongkol, S., Margolis, D. J., Avigan, M., . . . Cheng, M. Y. (2017). Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Standard Reporting and Evaluation Guidelines Results of a National Institutes of Health Working Group. JAMA DERMATOLOGY, 153(6), 587-592. doi:10.1001/jamadermatol.2017.0160

DOI
10.1001/jamadermatol.2017.0160
Journal article

17q21 Gene Variance Increases The Risk Of Exacerbations In Asthmatic Children Treated With Inhaled Corticosteroids: A Meta-Analysis In The Pica Consortium

Farzan, N., Vijverberg, S., Hernandez-Pacheco, N., Berce, V., Burchard, E. G., Canino, G., . . . Maitland-van Der Zee, A. -H. (2017). 17q21 Gene Variance Increases The Risk Of Exacerbations In Asthmatic Children Treated With Inhaled Corticosteroids: A Meta-Analysis In The Pica Consortium. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 195. Washington DC. Retrieved from http://gateway.webofknowledge.com/

Conference Paper

Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-wide Association Study.

Nicoletti, P., Aithal, G. P., Bjornsson, E. S., Andrade, R. J., Sawle, A., Arrese, M., . . . Daly, A. K. (2017). Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-wide Association Study.. Gastroenterology, 152(5), 1078-1089. doi:10.1053/j.gastro.2016.12.016

DOI
10.1053/j.gastro.2016.12.016
Journal article

Genome-Wide Association Study of Nevirapine Hypersensitivity in a sub-Saharan African HIV-infected Population

Carr, D. F., Bourgeois, S., Chaponda, M., Takeshita, L., Morris, A., Cornejo Castro, E. M., . . . Pirmohamed, M. (2017). Genome-Wide Association Study of Nevirapine Hypersensitivity in a sub-Saharan African HIV-infected Population. Journal of Antimicrobial Chemotherapy, 72(4), 1152-1162. doi:10.1093/jac/dkw545

DOI
10.1093/jac/dkw545
Journal article

Open letter on access to the BIA 10-2474 clinical trial data

Brosen, K., Funck-Brentano, C., Kroemer, H. K., Pirmohamed, M., & Schwab, M. (2017). Open letter on access to the BIA 10-2474 clinical trial data. LANCET, 389(10065), 156. doi:10.1016/S0140-6736(16)32515-6

DOI
10.1016/S0140-6736(16)32515-6
Journal article

Estimating the Pertinent Information Present in Social Media, not just what an Algorithm Detects

Maskell, S., Sloane, R., Perkins, S., Heap, J., Hajne, J., Jones, A., & Pirmohamed, M. (2017). Estimating the Pertinent Information Present in Social Media, not just what an Algorithm Detects. Poster session presented at the meeting of Unknown Conference. Retrieved from https://www.webofscience.com/

Poster

Genome-Wide Association Study Links Variants With Occurrence of Cardiovascular Events in People Taking the COX-2 Inhibitor Celecoxib: Identification of NCKX2 as a Novel Protective Pathway in Renal Vessels

Kirkby, N. S., Morris, A. P., Lytton, J., Seong, J. K., Bae, Y. S., Chu, J. H., . . . Mitchell, J. A. (2017). Genome-Wide Association Study Links Variants With Occurrence of Cardiovascular Events in People Taking the COX-2 Inhibitor Celecoxib: Identification of NCKX2 as a Novel Protective Pathway in Renal Vessels. In CIRCULATION Vol. 136. Retrieved from https://www.webofscience.com/

Conference Paper

Investigating the prevalence, predictors, and prognosis of suboptimal statin use early after a non-ST elevation acute coronary syndrome

Turner, R. M., Yin, P., Hanson, A., FitzGerald, R., Morris, A. P., Stables, R. H., . . . Pirmohamed, M. (2017). Investigating the prevalence, predictors, and prognosis of suboptimal statin use early after a non-ST elevation acute coronary syndrome. Journal of Clinical Lipidology, 11(1), 204-214. doi:10.1016/j.jacl.2016.12.007

DOI
10.1016/j.jacl.2016.12.007
Journal article

Looking Longitudinally in Twitter: Reading More than 140 Characters

Maskell, S., Sloane, R., Hajne, J., Heap, J., Perkins, S., Griffith, E., . . . Pirmohamed, M. (2017). Looking Longitudinally in Twitter: Reading More than 140 Characters. Poster session presented at the meeting of Unknown Conference. Retrieved from https://www.webofscience.com/

Poster

STATIN-INDUCED MYTOTOXICITY

Pirmohamed, M. (2017). STATIN-INDUCED MYTOTOXICITY. In DRUG METABOLISM AND PHARMACOKINETICS Vol. 32 (pp. S10). Retrieved from https://www.webofscience.com/

Conference Paper

2016

A combination of clinical and genetic covariates significantly influence the metabolism of carbamazepine: potential implications for carbamazepine hypersensitivity

Yip, V. L. M., Meng, X., Maggs, J. L., Pertinez, H., Carr, D. F., Marson, A. G., . . . Pirmohamed, M. (2016). A combination of clinical and genetic covariates significantly influence the metabolism of carbamazepine: potential implications for carbamazepine hypersensitivity. London, UK.

Presentation material

A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease

Walker, L., Griffiths, M. J., McGill, F., Lewthwaite, P., Sills, G. J., Jorgensen, A., . . . Pirmohamed, M. (2016). A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease. Biomarkers, 22(7), 635-642. doi:10.1080/1354750X.2016.1265003

DOI
10.1080/1354750X.2016.1265003
Journal article

Discordant CSF/plasma HIV-1 RNA in patients with unexplained low-level viraemia

Nightingale, S., Geretti, A. M., Beloukas, A., Fisher, M., Winston, A., Else, L., . . . Khoo, S. (2016). Discordant CSF/plasma HIV-1 RNA in patients with unexplained low-level viraemia. Journal of NeuroVirology, 22, 852-860. doi:10.1007/s13365-016-0448-1

DOI
10.1007/s13365-016-0448-1
Journal article

Genotype-guided warfarin dosing

Yip, V. L. M., & Pirmohamed, M. (2016). Genotype-guided warfarin dosing. Manchester, UK.

Presentation material

Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis

Fjeld, K., Beer, S., Johnstone, M., Zimmer, C., Moessner, J., Ruffert, C., . . . Rosendahl, J. (2016). Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis. PLOS ONE, 11(11). doi:10.1371/journal.pone.0165567

DOI
10.1371/journal.pone.0165567
Journal article

Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients

Qin, S., Zhou, Y., Gray, L., Kusebauch, U., McEvoy, L., Antoine, D. J., . . . Hood, L. (2016). Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients. Journal of proteome research, 15(10), 3724-3740. doi:10.1021/acs.jproteome.6b00547

DOI
10.1021/acs.jproteome.6b00547
Journal article

A Randomized Controlled Trial of Extended Brief Intervention for Alcohol-Dependent Patients in an Acute Hospital Setting

Owens, L., Kolamunnage-Dona, R., Owens, A., Perkins, E., Butcher, G., Wilson, K., . . . Pirmohamed, M. (2016). A Randomized Controlled Trial of Extended Brief Intervention for Alcohol-Dependent Patients in an Acute Hospital Setting. Alcohol and Alcoholism, 51(05), 584-592. doi:10.1093/alcalc/agw023

DOI
10.1093/alcalc/agw023
Journal article

PAEDIATRIC ADVERSE DRUG REACTIONS (ADRS): A COMPARISON OF A NEWLY DEVELOPED AVOIDABILITY TOOL TO EXISTING HALLAS ASSESSMENTS.

Bracken, L., Kirkham, J., Nunn, A., Pirmohamed, M., Peak, M., & Turner, M. (2016). PAEDIATRIC ADVERSE DRUG REACTIONS (ADRS): A COMPARISON OF A NEWLY DEVELOPED AVOIDABILITY TOOL TO EXISTING HALLAS ASSESSMENTS.. Poster session presented at the meeting of Unknown Conference.

DOI
10.1136/archdischild-2016-311535.72
Poster

A Systematic Review of Economic Evaluations of Pharmacogenetic Testing for Prevention of Adverse Drug Reactions

Plumpton, C. O., Roberts, D., Pirmohamed, M., & Hughes, D. A. (2016). A Systematic Review of Economic Evaluations of Pharmacogenetic Testing for Prevention of Adverse Drug Reactions. PHARMACOECONOMICS, 34(8), 771-793. doi:10.1007/s40273-016-0397-9

DOI
10.1007/s40273-016-0397-9
Journal article

Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with CYP2B6 c.516G -> T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis

Nightingale, S., Chau, T. T. H., Fisher, M., Nelson, M., Winston, A., Else, L., . . . Grp, P. -V. S. (2016). Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with CYP2B6 c.516G -> T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis. Antimicrobial Agents and Chemotherapy, 60(8), 4511-4518. doi:10.1128/AAC.00280-16

DOI
10.1128/AAC.00280-16
Journal article

CSF/plasma HIV-1 RNA discordance even at low levels is associated with up-regulation of host inflammatory mediators in CSF

Nightingale, S., Michael, B. D., Fisher, M., Winston, A., Nelson, M., Taylor, S., . . . Solomon, T. (2016). CSF/plasma HIV-1 RNA discordance even at low levels is associated with up-regulation of host inflammatory mediators in CSF. Cytokine, 83, 139-146. doi:10.1016/j.cyto.2016.04.004

DOI
10.1016/j.cyto.2016.04.004
Journal article

Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21,-200c, and-423

Pavkovic, M., Robinson-Cohen, C., Chua, A. S., Nicoara, O., Cardenas-Gonzalez, M., Bijol, V., . . . Vaidya, V. S. (2016). Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21,-200c, and-423. TOXICOLOGICAL SCIENCES, 152(1), 205-213. doi:10.1093/toxsci/kfw077

DOI
10.1093/toxsci/kfw077
Journal article

Pharmacogenetics for the prescriber

Pirmohamed, M. (2016). Pharmacogenetics for the prescriber. Medicine, 44(7), 412-415. doi:10.1016/j.mpmed.2016.04.010

DOI
10.1016/j.mpmed.2016.04.010
Journal article

Pharmacogenetics and Pharmacogenomics

Alfirevic, A., & Pirmohamed, M. (2016). Pharmacogenetics and Pharmacogenomics. In Medical and Health Genomics (pp. 121-137). Elsevier. doi:10.1016/b978-0-12-420196-5.00010-1

DOI
10.1016/b978-0-12-420196-5.00010-1
Chapter

A randomised controlled trial of extended brief intervention for alcohol dependent patients in an acute hospital setting (ADPAC)

Owens, L., Butcher, G., Gilmore, I., Kolamunnage-Dona, R., Oyee, J., Perkins, L., . . . Pirmohamed, M. (2011). A randomised controlled trial of extended brief intervention for alcohol dependent patients in an acute hospital setting (ADPAC). BMC Public Health, 11, 528.

Journal article

Adrenal responses to a low-dose short synacthen test in children with asthma (vol 82, pg 648, 2015)

Hawcutt, D. B., Jorgensen, A. L., Wallin, N., Thompson, B., Peak, M., Lacy, D., . . . Smyth, R. L. (2016). Adrenal responses to a low-dose short synacthen test in children with asthma (vol 82, pg 648, 2015). CLINICAL ENDOCRINOLOGY, 84(5), 793. doi:10.1111/cen.13069

DOI
10.1111/cen.13069
Journal article

Pharmacogenetics

Pirmohammed, M. (n.d.). Pharmacogenetics. Bioscientifica. doi:10.1530/boneabs.3.w2.3

DOI
10.1530/boneabs.3.w2.3
Book

Pharmacogenetics and metabolic disease

Constable, S., & Pirmohamed, M. (2016). Pharmacogenetics and metabolic disease. In Pharmacogenetics (pp. 243-272).

Chapter

Preface

Hall, I. P., & Pirmohamed, M. (2016). Preface.

Book

Progress in pharmacogenetics: consortiums and new strategies.

Maroñas, O., Latorre, A., Dopazo, J., Pirmohamed, M., Rodríguez-Antona, C., Siest, G., . . . LLerena, A. (2016). Progress in pharmacogenetics: consortiums and new strategies.. Drug metabolism and personalized therapy, 31(1), 17-23. doi:10.1515/dmpt-2015-0039

DOI
10.1515/dmpt-2015-0039
Journal article

Achieving the World Health Organization's vision for clinical pharmacology

Martin, J. H., Henry, D., Gray, J., Day, R., Bochner, F., Ferro, A., . . . Schwab, M. (2016). Achieving the World Health Organization's vision for clinical pharmacology. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 81(2), 223-227. doi:10.1111/bcp.12803

DOI
10.1111/bcp.12803
Journal article

Advances in the Pharmacogenomics of Adverse Drug Reactions

Collins, S. L., Carr, D. F., & Pirmohamed, M. (2016). Advances in the Pharmacogenomics of Adverse Drug Reactions. DRUG SAFETY, 39(1), 15-27. doi:10.1007/s40264-015-0367-8

DOI
10.1007/s40264-015-0367-8
Journal article

Drug Transporters at the Blood-Brain Barrier

Dickens, D., Radisch, S., & Pirmohamed, M. (2016). Drug Transporters at the Blood-Brain Barrier. In DRUG TRANSPORTERS: VOL 1: ROLE AND IMPORTANCE IN ADME AND DRUG DEVELOPMENT (Vol. 54, pp. 151-183). Retrieved from https://www.webofscience.com/

Chapter

Personalized Medicine in Cardiovascular Disease

Turner, R. M., Bula, M., & Pirmohamed, M. (2017). Personalized Medicine in Cardiovascular Disease. In DIAGNOSTIC MOLECULAR PATHOLOGY: A GUIDE TO APPLIED MOLECULAR TESTING (pp. 457-471). doi:10.1016/B978-0-12-800886-7.00036-4

DOI
10.1016/B978-0-12-800886-7.00036-4
Chapter

Pivotal role of NFATc4 in antiretroviral-induced adipocyte toxicity

Majid, R., Pushpakom, S., & Pirmohamed, M. (2016). Pivotal role of NFATc4 in antiretroviral-induced adipocyte toxicity. Poster session presented at the meeting of Unknown Conference. Retrieved from https://www.webofscience.com/

Poster

2015

HEALTH-ECONOMIC EVALUATION OF CLOSTRIDIUM DIFFICILE INFECTION (CDI) AND EPIDEMIOLOGY IN ENGLAND AND MERSEYSIDE

Nakamura, C. A., Roberts, P., Beadsworth, M., O'Brien, S., Pirmohamed, M., Hughes, D., & Miyajima, F. (2015). HEALTH-ECONOMIC EVALUATION OF CLOSTRIDIUM DIFFICILE INFECTION (CDI) AND EPIDEMIOLOGY IN ENGLAND AND MERSEYSIDE. VALUE IN HEALTH, 18(7), A582. doi:10.1016/j.jval.2015.09.1947

DOI
10.1016/j.jval.2015.09.1947
Journal article

A pilot randomised controlled trial to assess the utility of an e-learning package that trains users in adverse drug reaction causality.

Conroy, E., Kirkham, J., Bellis, J., Peak, M., Smyth, R., Williamson, P., & Pirmohamed, M. (2015). A pilot randomised controlled trial to assess the utility of an e-learning package that trains users in adverse drug reaction causality.. The International Journal of Pharmacy Practice, 23(6), 447-455. doi:10.1111/ijpp.12197

DOI
10.1111/ijpp.12197
Journal article

Monocyte unresponsiveness and impaired IL1β, TNFα and IL7 production are associated with a poor outcome in Malawian adults with pulmonary tuberculosis

Waitt, C. J., Banda, P., Glennie, S., Kampmann, B., Squire, S. B., Pirmohamed, M., & Heyderman, R. S. (2015). Monocyte unresponsiveness and impaired IL1β, TNFα and IL7 production are associated with a poor outcome in Malawian adults with pulmonary tuberculosis. BMC Infectious Diseases, 15. doi:10.1186/s12879-015-1274-4

DOI
10.1186/s12879-015-1274-4
Journal article

Development of interferon beta-neutralising antibodies in multiple sclerosis-a systematic review and meta-analysis

Govindappa, K., Sathish, J., Park, K., Kirkham, J., & Pirmohamed, M. (2015). Development of interferon beta-neutralising antibodies in multiple sclerosis-a systematic review and meta-analysis. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 71(11), 1287-1298. doi:10.1007/s00228-015-1921-0

DOI
10.1007/s00228-015-1921-0
Journal article

Pharmacogenetic testing prior to carbamazepine treatment of epilepsy: patients' and physicians' preferences for testing and service delivery

Powell, G., Holmes, E. A. F., Plumpton, C. O., Ring, A., Baker, G. A., Jacoby, A., . . . Hughes, D. A. (2015). Pharmacogenetic testing prior to carbamazepine treatment of epilepsy: patients' and physicians' preferences for testing and service delivery. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 80(5), 1149-1159. doi:10.1111/bcp.12715

DOI
10.1111/bcp.12715
Journal article

<i>In Vitro</i> Priming of Naive T-cells with <i>p</i>-Phenylenediamine and Bandrowski's Base

Gibson, A., Kim, S. -H., Faulkner, L., Evely, J., Pirmohamed, M., Park, K. B., & Naisbitt, D. J. (2015). <i>In Vitro</i> Priming of Naive T-cells with <i>p</i>-Phenylenediamine and Bandrowski's Base. CHEMICAL RESEARCH IN TOXICOLOGY, 28(10), 2069-2077. doi:10.1021/acs.chemrestox.5b00294

DOI
10.1021/acs.chemrestox.5b00294
Journal article

Telmisartan and Insulin Resistance in HIV (TAILoR): protocol for a dose-ranging phase II randomised open-labelled trial of telmisartan as a strategy for the reduction of insulin resistance in HIVpositive individuals on combination antiretroviral therapy

Pushpakom, S., Taylor, C., Kolamunnage-Dona, R., Spowart, C., Vora, J., Garcia Finana, M., . . . Pirmohamed, M. (2015). Telmisartan and Insulin Resistance in HIV (TAILoR): protocol for a dose-ranging phase II randomised open-labelled trial of telmisartan as a strategy for the reduction of insulin resistance in HIVpositive individuals on combination antiretroviral therapy. BMJ Open, 5(10). doi:10.1136/bmjopen-2015-009566

DOI
10.1136/bmjopen-2015-009566
Journal article

Genotype-guided versus standard vitamin K antagonist dosing algorithms in patients initiating anticoagulation

Belley-Cote, E. P., Hanif, H., D'Aragon, F., Eikelboom, J. W., Anderson, J. L., Borgman, M., . . . Whitlock, R. P. (n.d.). Genotype-guided versus standard vitamin K antagonist dosing algorithms in patients initiating anticoagulation. THROMBOSIS AND HAEMOSTASIS, 114(4), 768-777. doi:10.1160/TH15-01-0071

DOI
10.1160/TH15-01-0071
Journal article

Prescribing in liver disease

Pirmohamed, M. (2015). Prescribing in liver disease. Medicine, 43(10), 577-580. doi:10.1016/j.mpmed.2015.07.015

DOI
10.1016/j.mpmed.2015.07.015
Journal article

Copy number variation in exportin-4 (<i>XPO4</i>) gene and its association with histological severity of non-alcoholic fatty liver disease

Zain, S. M., Mohamed, Z., Pirmohamed, M., Tan, H. L., Alshawsh, M. A., Mahadeva, S., . . . Mohamed, R. (2015). Copy number variation in exportin-4 (<i>XPO4</i>) gene and its association with histological severity of non-alcoholic fatty liver disease. SCIENTIFIC REPORTS, 5. doi:10.1038/srep13306

DOI
10.1038/srep13306
Journal article

HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis

Ogese, M. O., Saide, K., Faulkner, L., Whitaker, P., Peckham, D., Alfirevic, A., . . . Naisbitt, D. J. (2015). HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis. CLINICAL AND EXPERIMENTAL ALLERGY, 45(8), 1305-1316. doi:10.1111/cea.12546

DOI
10.1111/cea.12546
Journal article

New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity

Pirmohamed, M., Ostrov, D. A., & Park, B. K. (2015). New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136(2), 236-244. doi:10.1016/j.jaci.2015.06.022

DOI
10.1016/j.jaci.2015.06.022
Journal article

Variation in warfarin prescribing and dosing in the UK: a national survey of anticoagulation clinics

Stewart, A., Ganguli, A., FitzGerald, R., & Pirmohamed, M. (2015). Variation in warfarin prescribing and dosing in the UK: a national survey of anticoagulation clinics. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 40(4), 466-471. doi:10.1111/jcpt.12291

DOI
10.1111/jcpt.12291
Journal article

Genome-wide association study of warfarin maintenance dose in a Brazilian sample

Parra, E. J., Botton, M. R., Perini, J. A., Krithika, S., Bourgeois, S., Johnson, T. A., . . . Suarez-Kurtz, G. (2015). Genome-wide association study of warfarin maintenance dose in a Brazilian sample. PHARMACOGENOMICS, 16(11), 1253-1263. doi:10.2217/pgs.15.73

DOI
10.2217/pgs.15.73
Journal article

Quality of life in patients with venous thromboembolism and atrial fibrillation treated with coumarin anticoagulants

Marvig, C. L., Verhoef, T. I., de Boer, A., Kamali, F., Redekop, K., Pirmohamed, M., . . . Maitland-van der Zee, A. H. (2015). Quality of life in patients with venous thromboembolism and atrial fibrillation treated with coumarin anticoagulants. THROMBOSIS RESEARCH, 136(1), 69-75. doi:10.1016/j.thromres.2015.04.026

DOI
10.1016/j.thromres.2015.04.026
Journal article

Genetics of Immune-Mediated Adverse Drug Reactions: a Comprehensive and Clinical Review

Yip, V. L. M., Alfirevic, A., & Pirmohamed, M. (2015). Genetics of Immune-Mediated Adverse Drug Reactions: a Comprehensive and Clinical Review. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 48(2-3), 165-175. doi:10.1007/s12016-014-8418-y

DOI
10.1007/s12016-014-8418-y
Journal article

Misoprostol-induced fever and genetic polymorphisms in drug transporters <i>SLCO1B1</i> and <i>ABCC4</i> in women of Latin American and European ancestry

Alfirevic, A., Durocher, J., Elati, A., Leon, W., Dickens, D., Raedisch, S., . . . Winikoff, B. (2015). Misoprostol-induced fever and genetic polymorphisms in drug transporters <i>SLCO1B1</i> and <i>ABCC4</i> in women of Latin American and European ancestry. PHARMACOGENOMICS, 16(9), 919-928. doi:10.2217/pgs.15.53

DOI
10.2217/pgs.15.53
Journal article

ST13 polymorphisms and their effect on exacerbations in steroid‐treated asthmatic children and young adults

Vijverberg, S. J. H., Koster, E. S., Tavendale, R., Leusink, M., Koenderman, L., Raaijmakers, J. A. M., . . . Maitland-van der Zee, A. H. (2015). ST13 polymorphisms and their effect on exacerbations in steroid‐treated asthmatic children and young adults. Clinical and Experimental Allergy, 45(6), 1051-1059. doi:10.1111/cea.12492

DOI
10.1111/cea.12492
Journal article

BACLOFEN: MAINTENANCE OF ABSTINENCE IN ALCOHOL DEPENDENT PATIENTS ATTENDING LIVER CLINIC

Owens, L., Rose, A., Thompson, A., Pirmohamed, M., Gilmore, I., & Richardson, P. (2015). BACLOFEN: MAINTENANCE OF ABSTINENCE IN ALCOHOL DEPENDENT PATIENTS ATTENDING LIVER CLINIC. In JOURNAL OF HEPATOLOGY Vol. 62 (pp. S767). doi:10.1016/S0168-8278(15)31309-X

DOI
10.1016/S0168-8278(15)31309-X
Conference Paper

Cost‐effectiveness of screening for HLA ‐A *31:01 prior to initiation of carbamazepine in epilepsy

Plumpton, C. O., Yip, V. L. M., Alfirevic, A., Marson, A. G., Pirmohamed, M., & Hughes, D. A. (2015). Cost‐effectiveness of screening for HLA ‐A *31:01 prior to initiation of carbamazepine in epilepsy. EPILEPSIA, 56(04), 556-563. doi:10.1111/epi.12937

DOI
10.1111/epi.12937
Journal article

HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta-analysis.

Cornejo Castro, E. M., Carr, D., Jorgensen, A., Alfirevic, A., & Pirmohamed, M. (2015). HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta-analysis.. Pharmacogenetics and genomics, 25(04), 186-198. doi:10.1097/FPC.0000000000000124

DOI
10.1097/FPC.0000000000000124
Journal article

Management of allergy to penicillins and other beta-lactams

Mirakian, R., Leech, S. C., Krishna, M. T., Richter, A. G., Huber, P. A. J., Farooque, S., . . . Nasser, S. M. (2015). Management of allergy to penicillins and other beta-lactams. CLINICAL AND EXPERIMENTAL ALLERGY, 45(2), 300-327. doi:10.1111/cea.12468

DOI
10.1111/cea.12468
Journal article

Personalized medicine approaches in epilepsy

Walker, L. E., Mirza, N., Yip, V. L. M., Marson, A. G., & Pirmohamed, M. (2015). Personalized medicine approaches in epilepsy. JOURNAL OF INTERNAL MEDICINE, 277(2), 218-234. doi:10.1111/joim.12322

DOI
10.1111/joim.12322
Journal article

Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury

Cross, M. J., Berridge, B. R., Clements, P. J. M., Cove-Smith, L., Force, T. L., Hoffmann, P., . . . Park, B. K. (2015). Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury. BRITISH JOURNAL OF PHARMACOLOGY, 172(4), 957-974. doi:10.1111/bph.12979

DOI
10.1111/bph.12979
Journal article

Nalmefene in Supporting Alcohol Reduction: Observations from a Clinical Cohort

Owens, L., Thompson, A., Pirmohamed, M., Gilmore, I., & Richardson, P. (2015). Nalmefene in Supporting Alcohol Reduction: Observations from a Clinical Cohort. Journal of Addiction Medicine and Therapy, 3(1).

Journal article

<i>HLA</i>-<i>A</i>*<i>33</i>:<i>01</i> is strongly associated with drug-induced liver injury (DILI) due to terbinafine and several other unrelated compounds

Aithal, G. P., Nicoletti, P., Bjornsson, E., Lucena, M. I., Andrade, R. J., Grove, J., . . . Daly, A. K. (2015). <i>HLA</i>-<i>A</i>*<i>33</i>:<i>01</i> is strongly associated with drug-induced liver injury (DILI) due to terbinafine and several other unrelated compounds. In HEPATOLOGY Vol. 62 (pp. 325A-326A). Retrieved from https://www.webofscience.com/

Conference Paper

A Duplication Copy Number Variation in the Exportin-4 (XPO4) is a Predictor for Histological Severity of Non-Alcoholic Fatty Liver Disease

Zain, S. M., Mohamed, Z., Pirmohamed, M., Tan, H. L., & Mohamed, R. (2015). A Duplication Copy Number Variation in the Exportin-4 (XPO4) is a Predictor for Histological Severity of Non-Alcoholic Fatty Liver Disease. PUBLIC HEALTH GENOMICS, 18, 27. Retrieved from https://www.webofscience.com/

Journal article

A comprehensive omics assessment of etanercept therapy for psoriasis

Foulkes, A., Rattray, N. J. W., Correa, E., Trivedi, D. K., Carr, D. F., Maratou, K., . . . Warren, R. (2015). A comprehensive omics assessment of etanercept therapy for psoriasis. In BRITISH JOURNAL OF DERMATOLOGY Vol. 173 (pp. 12). Retrieved from https://www.webofscience.com/

Conference Paper

A comprehensive omics assessment of etanercept therapy for psoriasis

Foulkes, A., Rattray, N., Pirmohamed, M., Goodacre, R., Reynolds, N. J., Donaldson, M. J., . . . Warren, R. (2015). A comprehensive omics assessment of etanercept therapy for psoriasis. In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 135 (pp. S32). Retrieved from https://www.webofscience.com/

Conference Paper

ACUTE KIDNEY INJURY IN PAEDIATRIC ONCOLOGY PATIENTS RECEIVING CISPLATIN

Barton, C., Hawcutt, D., Pirmohamed, M., & Pizer, B. (2015). ACUTE KIDNEY INJURY IN PAEDIATRIC ONCOLOGY PATIENTS RECEIVING CISPLATIN. PEDIATRIC BLOOD & CANCER, 62, S302-S303. Retrieved from https://www.webofscience.com/

Journal article

CSF:plasma HIV-1 RNA discordance &gt;0.5 log<sub>10</sub> is associated with raised inflammatory mediator profiles in CSF

Nightingale, S., Michael, B., King, S., Beloukas, A., Pirmohamed, M., Geretti, A. M., . . . Post, F. (2015). CSF:plasma HIV-1 RNA discordance &gt;0.5 log<sub>10</sub> is associated with raised inflammatory mediator profiles in CSF. HIV MEDICINE, 16, 7. Retrieved from https://www.webofscience.com/

Journal article

Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses

Gibson, A., Faulkner, L., Ogese, M., Lichtenfels, M., Esser, P., Martin, S., . . . Naisbitt, D. (2015). Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses. In ALLERGY Vol. 70 (pp. 26). Retrieved from https://www.webofscience.com/

Conference Paper

MARKERS OF TUBULAR RENAL INJURY IN CHILDREN WITH CANCER RECEIVING CISPLATIN AND/OR IFOSFAMIDE

Barton, C., Hawcutt, D., Pirmohamed, M., & Pizer, B. (2015). MARKERS OF TUBULAR RENAL INJURY IN CHILDREN WITH CANCER RECEIVING CISPLATIN AND/OR IFOSFAMIDE. PEDIATRIC BLOOD & CANCER, 62, S302. Retrieved from https://www.webofscience.com/

Journal article

Oral anticoagulation: a critique of recent advances and controversies

Pirmohamed, M., Kamali, F., Daly, A. K., & Wadelius, M. (2015). Oral anticoagulation: a critique of recent advances and controversies. TRENDS IN PHARMACOLOGICAL SCIENCES, 36(3), 153-163. doi:10.1016/j.tips.2015.01.003

DOI
10.1016/j.tips.2015.01.003
Journal article

Pharmacogenetics of Acute Coronary Syndrome

Yin, P., Jorgensen, A., Morris, A. P., Turner, R., Fitzgerald, R., Stables, R., . . . Pirmohamed, M. (2015). Pharmacogenetics of Acute Coronary Syndrome. In GENETIC EPIDEMIOLOGY Vol. 39 (pp. 596). Retrieved from https://www.webofscience.com/

Conference Paper

Pharmacogenetics of Adverse Drug Reactions

Turner, R. M., & Pirmohamed, M. (2015). Pharmacogenetics of Adverse Drug Reactions. In PREVENTIVE AND PREDICTIVE GENETICS: TOWARDS PERSONALISED MEDICINE (Vol. 9, pp. 109-156). doi:10.1007/978-3-319-15344-5_6

DOI
10.1007/978-3-319-15344-5_6
Chapter

Pharmacogenomics: The Hierarchy of Evidence

Pirmohamed, M. (2015). Pharmacogenomics: The Hierarchy of Evidence. PUBLIC HEALTH GENOMICS, 18, 2. Retrieved from https://www.webofscience.com/

Journal article

Redefining antigen binding specificity through small molecule-HLA interactions: Drug hypersensitivity and beyond!

Illing, P. T., Vivian, J. P., Dudek, N. L., Mifsud, N. L., Croft, N. P., Miles, J. J., . . . Purcell, A. W. (2015). Redefining antigen binding specificity through small molecule-HLA interactions: Drug hypersensitivity and beyond!. In MOLECULAR IMMUNOLOGY Vol. 68 (pp. 135). Retrieved from https://www.webofscience.com/

Conference Paper

The Influence of Pharmacogenetics on the Time to Acute Coronary Syndrome Recurrence in a UK Cohort Study

Yin, P., Jorgensen, A., Morris, A., Turner, R., Fitzgerald, R., Stables, R., . . . Pirmohamed, M. (2015). The Influence of Pharmacogenetics on the Time to Acute Coronary Syndrome Recurrence in a UK Cohort Study. In HUMAN HEREDITY Vol. 80 (pp. 123). Retrieved from https://www.webofscience.com/

Conference Paper

2014

Clinical coding of prospectively identified paediatric adverse drug reactions – a retrospective review of patient records

Bellis, J. R., Kirkham, J. J., Nunn, A. J., & Pirmohamed, M. (2014). Clinical coding of prospectively identified paediatric adverse drug reactions – a retrospective review of patient records. BMC PHARMACOLOGY & TOXICOLOGY, 15. doi:10.1186/2050-6511-15-72

DOI
10.1186/2050-6511-15-72
Journal article

A Review of A Priori Regression Models for Warfarin Maintenance Dose Prediction

Francis, B., Lane, S., Pirmohamed, M., & Jorgensen, A. (2014). A Review of A Priori Regression Models for Warfarin Maintenance Dose Prediction. PLoS One, 9(12). doi:10.1371/journal.pone.0114896

DOI
10.1371/journal.pone.0114896
Journal article

Pharmacogenetics of warfarin in a paediatric population: time in therapeutic range, initial and stable dosing and adverse effects.

Hawcutt, D., Ghani, A., Sutton, L., Jorgensen, A., Zhang, E., Murray, M., . . . Pirmohamed, M. (2014). Pharmacogenetics of warfarin in a paediatric population: time in therapeutic range, initial and stable dosing and adverse effects.. The Pharmacogenomics Journal, 14(6), 542-548. doi:10.1038/tpj.2014.31

DOI
10.1038/tpj.2014.31
Journal article

Dual Glutathione-<i>S</i>-Transferase-θ1 and -μ1 Gene Deletions Determine Imatinib Failure in Chronic Myeloid Leukemia

Davies, A., Giannoudis, A., Zhang, J. E., Austin, G., Wang, L., Holyoake, T. L., . . . Clark, R. E. (2014). Dual Glutathione-<i>S</i>-Transferase-θ1 and -μ1 Gene Deletions Determine Imatinib Failure in Chronic Myeloid Leukemia. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(6), 694-703. doi:10.1038/clpt.2014.176

DOI
10.1038/clpt.2014.176
Journal article

Validation of a multigenic model to predict seizure control in newly treated epilepsy

Shazadi, K., Petrovski, P., Roten, A., Miller, H., Huggins, R. M., Brodie, M. J., . . . Sills, G. (2014). Validation of a multigenic model to predict seizure control in newly treated epilepsy. Epilepsy Research, 108(10), 1797-1805. doi:10.1016/j.eplepsyres.2014.08.022

DOI
10.1016/j.eplepsyres.2014.08.022
Journal article

Serum Mannose-Binding Lectin Concentration, but Not Genotype, Is Associated With Clostridium difficile Infection Recurrence: A Prospective Cohort Study

Swale, A., Miyajima, F., Kolamunnage-Dona, R., Roberts, P., Little, M., Beeching, N., . . . Pirmohamed, M. (2014). Serum Mannose-Binding Lectin Concentration, but Not Genotype, Is Associated With Clostridium difficile Infection Recurrence: A Prospective Cohort Study. Clinical Infectious Diseases, 59(10), 1429-1436. doi:10.1093/cid/ciu666

DOI
10.1093/cid/ciu666
Journal article

A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine

Raedisch, S., Dickens, D., Lang, T., Bonnett, L., Arlanov, R., Johnson, M. R., . . . Pirmohamed, M. (2014). A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine. PHARMACOGENOMICS JOURNAL, 14(5), 481-487. doi:10.1038/tpj.2014.5

DOI
10.1038/tpj.2014.5
Journal article

Phenotype Standardization for Statin-Induced Myotoxicity

Alfirevic, A., Neely, D., Armitage, J., Chinoy, H., Cooper, R. G., Laaksonen, R., . . . Pirmohamed, M. (2014). Phenotype Standardization for Statin-Induced Myotoxicity. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(4), 470-476. doi:10.1038/clpt.2014.121

DOI
10.1038/clpt.2014.121
Journal article

Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System

Wadelius, M., Marshall, S. E., Islander, G., Nordang, L., Karawajczyk, M., Yue, Q. -Y., . . . Palmer, C. N. A. (2014). Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(4), 477-481. doi:10.1038/clpt.2014.138

DOI
10.1038/clpt.2014.138
Journal article

WHICH GENETIC PATHWAYS UNDERLIE PHARMACORESISTANT EPILEPSY?

Mirza, N., Jorgensen, A., Sills, G., Johnson, M., Pirmohamed, M., & Marson, T. (2014). WHICH GENETIC PATHWAYS UNDERLIE PHARMACORESISTANT EPILEPSY?. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 85. doi:10.1136/jnnp-2014-309236.6

DOI
10.1136/jnnp-2014-309236.6
Conference Paper

Reporting of drug induced depression and fatal and non-fatal suicidal behaviour in the UK from 1998 to 2011

Thomas, K. H., Martin, R. M., Potokar, J., Pirmohamed, M., & Gunnell, D. (2014). Reporting of drug induced depression and fatal and non-fatal suicidal behaviour in the UK from 1998 to 2011. BMC PHARMACOLOGY & TOXICOLOGY, 15. doi:10.1186/2050-6511-15-54

DOI
10.1186/2050-6511-15-54
Journal article

GATM gene variants and statin myopathy risk

Carr, D., Alfirevic, A., Johnson, R., Chinoy, H., van Staa, T., & Pirmohamed, M. (2014). GATM gene variants and statin myopathy risk. Nature, 513(7518). doi:10.1038/nature13628

DOI
10.1038/nature13628
Journal article

Personalized Pharmacogenomics: Predicting Efficacy and Adverse Drug Reactions

Pirmohamed, M. (2014). Personalized Pharmacogenomics: Predicting Efficacy and Adverse Drug Reactions. ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 15, 15, 349-370. doi:10.1146/annurev-genom-090413-025419

DOI
10.1146/annurev-genom-090413-025419
Journal article

Calprotectin and Lactoferrin Faecal Levels in Patients with Clostridium difficile Infection (CDI): A Prospective Cohort Study

Swale, A., Miyajima, F., Roberts, P., Hall, A., Little, M., Beadsworth, M., . . . Pirmohamed, M. (2014). Calprotectin and Lactoferrin Faecal Levels in Patients with Clostridium difficile Infection (CDI): A Prospective Cohort Study. PLoS One, 9(8). doi:10.1371/journal.pone.0106118

DOI
10.1371/journal.pone.0106118
Journal article

Predictors and outcomes of increases in creatine phosphokinase concentrations or rhabdomyolysis risk during statin treatment

van Staa, T. P., Carr, D. F., O'Meara, H., McCann, G., & Pirmohamed, M. (2014). Predictors and outcomes of increases in creatine phosphokinase concentrations or rhabdomyolysis risk during statin treatment. British Journal of Clinical Pharmacology, 78(3), 649-659. doi:10.1111/bcp.12367

DOI
10.1111/bcp.12367
Journal article

Abs No: HLA-A*31:01 positive hypersensitive patient

Lichtenfels, M., Farrell, J., Ogese, M., Bell, C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). Abs No: HLA-A*31:01 positive hypersensitive patient. Clinical and translational allergy, 4(Suppl 3), P117. doi:10.1186/2045-7022-4-s3-p117

DOI
10.1186/2045-7022-4-s3-p117
Journal article

CYP2B6*18 is associated with nevirpine hypersensitivity independently of HLA-C*04:01 in a Malawian HIV population

Carr, D., Chaponda, M., Castro, E. C., Jorgensen, A., Khoo, S., & Pirmohamed, M. (2014). CYP2B6*18 is associated with nevirpine hypersensitivity independently of HLA-C*04:01 in a Malawian HIV population. Clinical and translational allergy, 4(Suppl 3), P126. doi:10.1186/2045-7022-4-s3-p126

DOI
10.1186/2045-7022-4-s3-p126
Journal article

Characterization of amoxicillin and clavulanic-acid-responsive CD4+ And CD8+ T-cells in patients with co-amoxiclav-induced liver injury

Kim, S. -H., Saide, K., Yuan, Y., Daly, A., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. (2014). Characterization of amoxicillin and clavulanic-acid-responsive CD4+ And CD8+ T-cells in patients with co-amoxiclav-induced liver injury. Clinical and translational allergy, 4(Suppl 3), P42. doi:10.1186/2045-7022-4-s3-p42

DOI
10.1186/2045-7022-4-s3-p42
Journal article

Establishment of an HLA-typed cohort of 1000 healthy blood donors and use of a dendritic cell priming assay to prime naive T cells to structurally divergent drugs

Faulkner, L., Wood, S., Van Eker, D., Alfirevic, A., Pirmohamed, M., Naisbitt, D., & Park, K. (2014). Establishment of an HLA-typed cohort of 1000 healthy blood donors and use of a dendritic cell priming assay to prime naive T cells to structurally divergent drugs. Clinical and translational allergy, 4(Suppl 3), P112. doi:10.1186/2045-7022-4-s3-p112

DOI
10.1186/2045-7022-4-s3-p112
Journal article

Identification of susceptible HLA class II co-amoxiclav genotypes based on the analysis of drug-specific T-cells from patients with liver injury

Saide, K., Kim, S. -H., Yuan, Y., Daly, A., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. (2014). Identification of susceptible HLA class II co-amoxiclav genotypes based on the analysis of drug-specific T-cells from patients with liver injury. Clinical and translational allergy, 4(Suppl 3), O3. doi:10.1186/2045-7022-4-s3-o3

DOI
10.1186/2045-7022-4-s3-o3
Journal article

Dexamethasone and haemorrhage risk in paediatric tonsillectomy: a systematic review and meta-analysis

Bellis, J., Pirmohamed, M., Nunn, A. J., Loke, Y. K., De, S., Golder, S., & Kirkham, J. J. (2014). Dexamethasone and haemorrhage risk in paediatric tonsillectomy: a systematic review and meta-analysis. British Journal of Anaesthesia, 113(1), 23-42. doi:10.1093/bja/aeu152

DOI
10.1093/bja/aeu152
Journal article

Mechanisms of Adverse Drug Reactions

Pirmohamed, M. (2014). Mechanisms of Adverse Drug Reactions. In Unknown Book (pp. 463-487). Wiley. doi:10.1002/9781118820186.ch30

DOI
10.1002/9781118820186.ch30
Chapter

Is the Interleukin 8 Promoter Polymorphism rs4073/–251T >A Associated With Clostridium difficile Infection?

Miyajima, F., Swale, A., Zhang, E., Alfirevic, A., Little, M., Beeching, N., . . . Pirmohamed, M. (2014). Is the Interleukin 8 Promoter Polymorphism rs4073/–251T >A Associated With Clostridium difficile Infection?. Clinical Infectious Disease, 58(12), e148-e151. doi:10.1093/cid/ciu152

DOI
10.1093/cid/ciu152
Journal article

Hemolytic anemia in two patients with glioblastoma multiforme: A possible interaction between vorinostat and dapsone

Lewis, J. A., Petty, W. J., Harmon, M., Peacock, J. E., Valente, K., Owen, J., . . . Lesser, G. J. (2015). Hemolytic anemia in two patients with glioblastoma multiforme: A possible interaction between vorinostat and dapsone. JOURNAL OF ONCOLOGY PHARMACY PRACTICE, 21(3), 220-223. doi:10.1177/1078155214524085

DOI
10.1177/1078155214524085
Journal article

BACLOFEN AS AN ADJUNCT PHARMACOTHERAPY FOR THE MAINTENANCE OF ABSTINENCE IN ALCOHOL DEPENDENT PATIENTS WITH LIVER DISEASE

Owens, L., Richardson, P., Pirmohamed, M., & Rose, A. (2014). BACLOFEN AS AN ADJUNCT PHARMACOTHERAPY FOR THE MAINTENANCE OF ABSTINENCE IN ALCOHOL DEPENDENT PATIENTS WITH LIVER DISEASE. In GUT Vol. 63 (pp. A90-A91). doi:10.1136/gutjnl-2014-307263.192

DOI
10.1136/gutjnl-2014-307263.192
Conference Paper

Pharmacogenomics: Current State-of-the-Art

Carr, D. F., Alfirevic, A., & Pirmohamed, M. (2014). Pharmacogenomics: Current State-of-the-Art. GENES, 5(2), 430-443. doi:10.3390/genes5020430

DOI
10.3390/genes5020430
Journal article

Adverse Drug Reactions

Walker, L., Yip, V., & Pirmohamed, M. (2014). Adverse Drug Reactions. In Handbook of Pharmacogenomics and Stratified Medicine (pp. 405-435). Elsevier. doi:10.1016/b978-0-12-386882-4.00020-7

DOI
10.1016/b978-0-12-386882-4.00020-7
Chapter

Genotype-Guided Dosing of Vitamin K Antagonists

Schwarz, U. I., Kim, R. B., & Tirona, R. G. (2014). Genotype-Guided Dosing of Vitamin K Antagonists. NEW ENGLAND JOURNAL OF MEDICINE, 370(18), 1761-1762. Retrieved from https://www.webofscience.com/

Journal article

Genotype-Guided Dosing of Vitamin K Antagonists

Koller, E. A., Roche, J. C., & Rollins, J. A. (2014). Genotype-Guided Dosing of Vitamin K Antagonists. NEW ENGLAND JOURNAL OF MEDICINE, 370(18), 1761. Retrieved from https://www.webofscience.com/

Journal article

Genotype-Guided Dosing of Vitamin K Antagonists

Cavallari, L. H., Kittles, R. A., & Perera, M. A. (2014). Genotype-Guided Dosing of Vitamin K Antagonists. NEW ENGLAND JOURNAL OF MEDICINE, 370(18), 1763. Retrieved from https://www.webofscience.com/

Journal article

Genotype-Guided Dosing of Vitamin K Antagonists

Daneshjou, R., Klein, T. E., & Altman, R. B. (2014). Genotype-Guided Dosing of Vitamin K Antagonists. NEW ENGLAND JOURNAL OF MEDICINE, 370(18), 1762-1763. Retrieved from https://www.webofscience.com/

Journal article

Genotype-Guided Dosing of Vitamin K Antagonists REPLY

Pirmohamed, M., Wadelius, M., & Kamali, F. (2014). Genotype-Guided Dosing of Vitamin K Antagonists REPLY. NEW ENGLAND JOURNAL OF MEDICINE, 370(18), 1764-1765. Retrieved from https://www.webofscience.com/

Journal article

Genotype-Guided Dosing of Vitamin K Antagonists REPLY

Kimmel, S. E., French, B., & Geller, N. L. (2014). Genotype-Guided Dosing of Vitamin K Antagonists REPLY. NEW ENGLAND JOURNAL OF MEDICINE, 370(18), 1763-1764. Retrieved from https://www.webofscience.com/

Journal article

Genotype-Guided Dosing of Vitamin K Antagonists REPLY

Maitland-van der Zee, A. H., de Boer, A., & Manolopoulos, V. G. (2014). Genotype-Guided Dosing of Vitamin K Antagonists REPLY. NEW ENGLAND JOURNAL OF MEDICINE, 370(18), 1765-1766. Retrieved from https://www.webofscience.com/

Journal article

Genotype-guided dosing of vitamin K antagonists.

Pereira, N. L., Rihal, C. S., & Weinshilboum, R. M. (2014). Genotype-guided dosing of vitamin K antagonists.. The New England journal of medicine, 370(18), 1762. doi:10.1056/nejmc1402521

DOI
10.1056/nejmc1402521
Journal article

Electronic Health Records For Biological Sample Collection: Feasibility Study Of Statin-Induced Myopathy Using The Clinical Practice Research Datalink

O'Meara, H., Carr, D. F., Evely, J., Hobbs, M., McCann, G., Van Staa, T., & Pirmohamed, M. (2014). Electronic Health Records For Biological Sample Collection: Feasibility Study Of Statin-Induced Myopathy Using The Clinical Practice Research Datalink. British Journal of Clinical Pharmacology, 77(5), 831-838. doi:10.1111/bcp.12269

DOI
10.1111/bcp.12269
Journal article

<SUP>19</SUP>F NMR Reveals Multiple Conformations at the Dimer Interface of the Nonstructural Protein 1 Effector Domain from Influenza A Virus

Aramini, J. M., Hamilton, K., Ma, L. -C., Swapna, G. V. T., Leonard, P. G., Ladbury, J. E., . . . Montelione, G. T. (2014). <SUP>19</SUP>F NMR Reveals Multiple Conformations at the Dimer Interface of the Nonstructural Protein 1 Effector Domain from Influenza A Virus. STRUCTURE, 22(4), 515-525. doi:10.1016/j.str.2014.01.010

DOI
10.1016/j.str.2014.01.010
Journal article

In AF or VTE, warfarin dosing by genotype improved time in therapeutic range but not clinical outcomes

Pirmohamed, M., Burnside, G., & Eriksson, N. (2014). In AF or VTE, warfarin dosing by genotype improved time in therapeutic range but not clinical outcomes. ANNALS OF INTERNAL MEDICINE, 160(6). doi:10.7326/0003-4819-160-6-201403180-02009

DOI
10.7326/0003-4819-160-6-201403180-02009
Journal article

Treatment of paracetamol overdose: room for improvement?

Park, K., Antoine, D. J., & Pirmohamed, M. (2014). Treatment of paracetamol overdose: room for improvement?. LANCET, 383(9918), 672-674. doi:10.1016/S0140-6736(13)62303-X

DOI
10.1016/S0140-6736(13)62303-X
Journal article

Adverse drug reactions and off-label and unlicensed medicines in children: a prospective cohort study of unplanned admissions to a paediatric hospital

Bellis, J. R., Kirkham, J. J., Nunn, A. J., & Pirmohamed, M. (2014). Adverse drug reactions and off-label and unlicensed medicines in children: a prospective cohort study of unplanned admissions to a paediatric hospital. British Journal of Clinical Pharmacology, 77(3), 545-553. doi:10.1111/bcp.12222

DOI
10.1111/bcp.12222
Journal article

HLA restriction of carbamazepine-specific T-cell clones from an HLA-A*31:01-positive hypersensitive patient

Lichtenfels, M., Farrell, J., Ogese, M. O., Bell, C. C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). HLA restriction of carbamazepine-specific T-cell clones from an HLA-A*31:01-positive hypersensitive patient. Chemical Research in Toxicology, 27(02), 175-177. doi:10.1021/tx400460w

DOI
10.1021/tx400460w
Journal article

Cost-effectiveness of pharmacogenetic guided warfarin therapy versus alternative anticoagulation in atrial fibrillation

Pink, J., Pirmohamed, M., Lane, S., & Hughes, D. A. (2014). Cost-effectiveness of pharmacogenetic guided warfarin therapy versus alternative anticoagulation in atrial fibrillation. Clinical Pharmacology and Therapeutics, 95(2), 199-207. doi:10.1038/clpt.2013.190

DOI
10.1038/clpt.2013.190
Journal article

Covalent adduction of carbamazepine 10, 11-epoxide with human serum albumin and glutathione S-transferase pi: implications for carbamazepine hypersensitivity

Yip, V., Maggs, J., Meng, X., Marson, A., Park, K., & Pirmohamed, M. (2014). Covalent adduction of carbamazepine 10, 11-epoxide with human serum albumin and glutathione S-transferase pi: implications for carbamazepine hypersensitivity. LANCET, 383, 114. Retrieved from https://www.webofscience.com/

Journal article

High mobility group box 1 in the inflammatory pathogenesis of epilepsy: profiling circulating levels after experimental and clinical seizures

Walker, L., Tse, K., Ricci, E., Thippeswamy, T., Sills, G. J., White, S. H., . . . Pirmohamed, M. (2014). High mobility group box 1 in the inflammatory pathogenesis of epilepsy: profiling circulating levels after experimental and clinical seizures. LANCET, 383, 105. Retrieved from https://www.webofscience.com/

Journal article

Population Pharmacokinetic and Pharmacogenetic Analysis of Nevirapine in Hypersensitive and Tolerant HIV-Infected Patients from Malawi

Dickinson, L., Chaponda, M., Carr, D. F., van Oosterhout, J. J., Kumwenda, J., Lalloo, D. G., . . . Khoo, S. H. (2014). Population Pharmacokinetic and Pharmacogenetic Analysis of Nevirapine in Hypersensitive and Tolerant HIV-Infected Patients from Malawi. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58(2), 706-712. doi:10.1128/AAC.02069-13

DOI
10.1128/AAC.02069-13
Journal article

Statins, Immunomodulation, and Infections: A Complex and Unresolved Relationship

Pirmohamed, M. (2014). Statins, Immunomodulation, and Infections: A Complex and Unresolved Relationship. CLINICAL INFECTIOUS DISEASES, 58(3), 357-358. doi:10.1093/cid/cit751

DOI
10.1093/cid/cit751
Journal article

<i>N</i>-acetyltransferase 2 (NAT2) genotype as a risk factor for development of drug-induced liver injury relating to antituberculosis drug treatment in a mixed-ethnicity patient group

Ng, C. -S., Hasnat, A., Al Maruf, A., Ahmed, M. U., Pirmohamed, M., Day, C. P., . . . Daly, A. K. (2014). <i>N</i>-acetyltransferase 2 (NAT2) genotype as a risk factor for development of drug-induced liver injury relating to antituberculosis drug treatment in a mixed-ethnicity patient group. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 70(9), 1079-1086. doi:10.1007/s00228-014-1703-0

DOI
10.1007/s00228-014-1703-0
Journal article

A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy

Speed, D., Hoggart, C., Petrovski, S., Tachmazidou, I., Coffey, A., Jorgensen, A., . . . Johnson, M. R. (2014). A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy. Human Molecular Genetics, 23(1), 247-258. doi:10.1093/hmg/ddt403

DOI
10.1093/hmg/ddt403
Journal article

A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy

Speed, D., Hoggart, C., Petrovski, S., Tachmazidou, I., Coffey, A., Jorgensen, A., . . . Johnson, M. R. (2014). A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy. Human Molecular Genetics, 23(1), 247-258. doi:10.1093/hmg/ddt403

DOI
10.1093/hmg/ddt403
Journal article

Assessing the reliability of exome sequencing to detect the filaggrin null mutations R501X and 2282del4

Thompson, B., Hawcutt, D., Carr, D., Bloch, K., Swale, A., Smyth, R., & Pirmohamed, M. (2014). Assessing the reliability of exome sequencing to detect the filaggrin null mutations R501X and 2282del4. In BRITISH JOURNAL OF DERMATOLOGY Vol. 171 (pp. 115-116). Retrieved from https://www.webofscience.com/

Conference Paper

CLINICAL PHARMACOGENOMICS

Pirmohamed, M. (2014). CLINICAL PHARMACOGENOMICS. In DRUG METABOLISM REVIEWS Vol. 45 (pp. 4). Retrieved from https://www.webofscience.com/

Conference Paper

Clinical Pharmacogenetics Implementation Consortium Guidelines for <i>HLA-B</i> Genotype and Abacavir Dosing: 2014 Update

Martin, M. A., Hoffman, J. M., Freimuth, R. R., Klein, T. E., Dong, B. J., Pirmohamed, M., . . . Kroetz, D. L. (2014). Clinical Pharmacogenetics Implementation Consortium Guidelines for <i>HLA-B</i> Genotype and Abacavir Dosing: 2014 Update. CLINICAL PHARMACOLOGY & THERAPEUTICS, 95(5), 499-500. doi:10.1038/clpt.2014.38

DOI
10.1038/clpt.2014.38
Journal article

Corrigendum: Patients Benefit From Genetics-Guided Coumarin Anticoagulant Therapy

Corrigendum: Patients Benefit From Genetics-Guided Coumarin Anticoagulant Therapy (2014). Clinical Pharmacology &amp; Therapeutics, 96(3), 397. doi:10.1038/clpt.2014.142

DOI
10.1038/clpt.2014.142
Journal article

Development of predictive genetic tests for improving the safety of new medicines: the utilization of routinely collected electronic health records

Wing, K., Douglas, I., Bhaskaran, K., Klungel, O. H., Reynolds, R. F., Pirmohamed, M., . . . van Staa, T. P. (2014). Development of predictive genetic tests for improving the safety of new medicines: the utilization of routinely collected electronic health records. DRUG DISCOVERY TODAY, 19(4), 361-366. doi:10.1016/j.drudis.2013.11.003

DOI
10.1016/j.drudis.2013.11.003
Journal article

Genotype-Guided Dosing of Vitamin K Antagonists

Pereira, N. L., Rihal, C. S., & Weinshilboum, R. M. (2014). Genotype-Guided Dosing of Vitamin K Antagonists. NEW ENGLAND JOURNAL OF MEDICINE, 370(18), 1762. Retrieved from https://www.webofscience.com/

Journal article

Genotype-Guided Vitamin K Antagonist Dosing Algorithms Improve Time in Therapeutic Range: A Systematic Review and Meta-Analysis

BeIley-Cote, E. P., Hanif, H., D'Aragon, F., Eikelboom, J., Anderson, J. L., Borgman, M., . . . Whitlock, R. (2014). Genotype-Guided Vitamin K Antagonist Dosing Algorithms Improve Time in Therapeutic Range: A Systematic Review and Meta-Analysis. In CIRCULATION Vol. 130. Retrieved from https://www.webofscience.com/

Conference Paper

IDENTIFYING THE CAUSES OF PHARMACORESISTANT EPILEPSY THROUGH A GENOME-WIDE ASSOCIATION STUDY WITH PATHWAY AND NETWORK ANALYSIS: FROM COMPLEXITY TO COHERENCE TO CENTRALITY

Mirza, N., Jorgensen, A., Sills, G., Johnson, M., Pirmohamed, M., & Marson, A. G. (2014). IDENTIFYING THE CAUSES OF PHARMACORESISTANT EPILEPSY THROUGH A GENOME-WIDE ASSOCIATION STUDY WITH PATHWAY AND NETWORK ANALYSIS: FROM COMPLEXITY TO COHERENCE TO CENTRALITY. In EPILEPSIA Vol. 55 (pp. 10). Retrieved from https://www.webofscience.com/

Conference Paper

Identifying the causes of pharmacoresistant epilepsy through a genome-wide association study with pathway and network analysis: from complexity to coherence to centrality

Mirza, N., Sills, G., Jorgensen, A., Johnson, M., Pirmohamed, M., & Marson, A. G. (2014). Identifying the causes of pharmacoresistant epilepsy through a genome-wide association study with pathway and network analysis: from complexity to coherence to centrality. In EUROPEAN JOURNAL OF NEUROLOGY Vol. 21 (pp. 755). Retrieved from https://www.webofscience.com/

Conference Paper

Identifying the causes of pharmacoresistant epilepsy through a genome-wide association study with pathway and network analysis: from complexity to coherence to centrality

Mirza, N., Sills, G., Jorgensen, A., Johnson, M., Pirmohamed, M., & Marson, A. G. (2014). Identifying the causes of pharmacoresistant epilepsy through a genome-wide association study with pathway and network analysis: from complexity to coherence to centrality. In JOURNAL OF NEUROLOGY Vol. 261 (pp. S484-S485). Retrieved from https://www.webofscience.com/

Conference Paper

Patients Benefit From Genetics-Guided Coumarin Anticoagulant Therapy

Maitland-van der Zee, A. H., Daly, A. K., Kamali, F., Manolopoulous, V. G., Verhoef, T. I., Wadelius, M., . . . Pirmohamed, M. (2014). Patients Benefit From Genetics-Guided Coumarin Anticoagulant Therapy. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(1), 15-17. doi:10.1038/clpt.2014.44

DOI
10.1038/clpt.2014.44
Journal article

Patients Benefit From Genetics-Guided Coumarin Anticoagulant Therapy (vol 96, pg 15, 2014)

Maitland-van der Zee, A. H., Daly, A. K., Kamali, F., Manolopoulous, V. G., Verhoef, T. I., Wadelius, M., . . . Pirmohamed, M. (2014). Patients Benefit From Genetics-Guided Coumarin Anticoagulant Therapy (vol 96, pg 15, 2014). CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(3), 397. Retrieved from https://www.webofscience.com/

Journal article

Pharmacogenetics of antiepileptic drug-induced hypersensitivity

Bloch, K. M., Sills, G. J., Pirmohamed, M., & Alfirevic, A. (2014). Pharmacogenetics of antiepileptic drug-induced hypersensitivity. PHARMACOGENOMICS, 15(6), 857-868. doi:10.2217/PGS.14.65

DOI
10.2217/PGS.14.65
Journal article

Pharmacogenomic signatures of response to etanercept therapy for psoriasis

Foulkes, A. C., Carr, D. F., Al-Sharqi, A., Parslew, R., Pirmohamed, M., Reynolds, N. J., . . . Warren, R. B. (2014). Pharmacogenomic signatures of response to etanercept therapy for psoriasis. In BRITISH JOURNAL OF DERMATOLOGY Vol. 171 (pp. E114-E115). Retrieved from https://www.webofscience.com/

Conference Paper

The clinical significance of ABCC3 as an imatinib transporter in chronic myeloid leukaemia

Giannoudis, A., Davies, A., Harris, B., Lucas, C., Pirmohamed, M., & Clark, R. (2014). The clinical significance of ABCC3 as an imatinib transporter in chronic myeloid leukaemia. Leukemia, 28(6), 1360-1363. doi:10.1038/leu.2014.38

DOI
10.1038/leu.2014.38
Journal article

The opportunities and challenges of pragmatic point-of-care randomised trials using routinely collected electronic records: evaluations of two exemplar trials

The opportunities and challenges of pragmatic point-of-care randomised trials using routinely collected electronic records: evaluations of two exemplar trials (2014). HEALTH TECHNOLOGY ASSESSMENT, 18(43), 1-+. Retrieved from https://www.webofscience.com/

Journal article

Thiopurine monitoring in children with inflammatory bowel disease: a systematic review

Konidari, A., Anagnostopoulos, A., Bonnett, L. J., Pirmohamed, M., & El-Matary, W. (2014). Thiopurine monitoring in children with inflammatory bowel disease: a systematic review. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 78(3), 467-476. doi:10.1111/bcp.12365

DOI
10.1111/bcp.12365
Journal article

2013

<i>CYP2B6</i>*<i>6</i> is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia

Johnson, G. G., Lin, K., Cox, T. F., Oates, M., Sibson, D. R., Eccles, R., . . . Pettitt, A. R. (2013). <i>CYP2B6</i>*<i>6</i> is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia. BLOOD, 122(26), 4253-4258. doi:10.1182/blood-2013-07-516666

DOI
10.1182/blood-2013-07-516666
Journal article

CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia

Johnson, G. G., Lin, K., Cox, T. F., Oates, M., Sibson, D. R., Eccles, R., . . . Pettitt, A. R. (2013). CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia. Blood, 122(26), 4253-4258. doi:10.1182/blood-2013-07-516666

DOI
10.1182/blood-2013-07-516666
Journal article

A Randomized Trial of Genotype-Guided Dosing of Acenocoumarol and Phenprocoumon

Verhoef, T. I., Ragia, G., de Boer, A., Barallon, R., Kolovou, G., Kolovou, V., . . . Maitland-van der Zee, A. H. (2013). A Randomized Trial of Genotype-Guided Dosing of Acenocoumarol and Phenprocoumon. NEW ENGLAND JOURNAL OF MEDICINE, 369(24), 2304-2312. doi:10.1056/NEJMoa1311388

DOI
10.1056/NEJMoa1311388
Journal article

A Randomized Trial of Genotype-Guided Dosing of Warfarin

Pirmohamed, M., Burnside, G., Eriksson, N., Jorgensen, A. L., Toh, C. H., Nicholson, T., . . . Wadelius, M. (2013). A Randomized Trial of Genotype-Guided Dosing of Warfarin. NEW ENGLAND JOURNAL OF MEDICINE, 369(24), 2294-2303. doi:10.1056/NEJMoa1311386

DOI
10.1056/NEJMoa1311386
Journal article

A Randomized Trial of Genotype-Guided Dosing of Warfarin

Pirmohamed, M., Burnside, G., Eriksson, N., Jorgensen, A. L., Toh, C. H., Nicholson, T., . . . Wadelius, M. (2013). A Randomized Trial of Genotype-Guided Dosing of Warfarin. New England Journal of Medicine, 369(24), 2294-2303. doi:10.1056/nejmoa1311386

DOI
10.1056/nejmoa1311386
Journal article

<i>SLCO1B1</i> Genetic Variant Associated With Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink

Carr, D. F., O'Meara, H., Jorgensen, A. L., Campbell, J., Hobbs, M., McCann, G., . . . Pirmohamed, M. (2013). <i>SLCO1B1</i> Genetic Variant Associated With Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink. CLINICAL PHARMACOLOGY & THERAPEUTICS, 94(6), 695-701. doi:10.1038/clpt.2013.161

DOI
10.1038/clpt.2013.161
Journal article

Adverse drug reactions and off-label and unlicensed medicines in children: a nested case-control study of inpatients in a pediatric hospital

Bellis, J. R., Kirkham, J. J., Thiesen, S., Conroy, E. J., Bracken, L. E., Mannix, H. L., . . . Pirmohamed, M. (2013). Adverse drug reactions and off-label and unlicensed medicines in children: a nested case-control study of inpatients in a pediatric hospital. BMC MEDICINE, 11. doi:10.1186/1741-7015-11-238

DOI
10.1186/1741-7015-11-238
Journal article

Incidence, characteristics and risk factors of adverse drug reactions in hospitalized children - a prospective observational cohort study of 6,601 admissions

Thiesen, S., Conroy, E. J., Bellis, J. R., Bracken, L. E., Mannix, H. L., Bird, K. A., . . . Smyth, R. L. (2013). Incidence, characteristics and risk factors of adverse drug reactions in hospitalized children - a prospective observational cohort study of 6,601 admissions. BMC MEDICINE, 11. doi:10.1186/1741-7015-11-237

DOI
10.1186/1741-7015-11-237
Journal article

COST EFFECTIVENESS OF PHARMACOGENETIC SCREENING PRIOR TO INITIATION OF CARBAMAZEPINE TREATMENT FOR EPILEPSY

Plumpton, C. O., Yip, V., Alfirevic, A., Marson, A., Pirmohamed, M., & Hughes, D. A. (2013). COST EFFECTIVENESS OF PHARMACOGENETIC SCREENING PRIOR TO INITIATION OF CARBAMAZEPINE TREATMENT FOR EPILEPSY. In VALUE IN HEALTH Vol. 16 (pp. A624). doi:10.1016/j.jval.2013.08.1831

DOI
10.1016/j.jval.2013.08.1831
Conference Paper

Clinical Pharmacogenetics Implementation Consortium Guidelines for <i>HLA-B</i> Genotype and Carbamazepine Dosing

Leckband, S. G., Kelsoe, J. R., Dunnenberger, H. M., George, A. L. J., Tran, E., Berger, R., . . . Pirmohamed, M. (2013). Clinical Pharmacogenetics Implementation Consortium Guidelines for <i>HLA-B</i> Genotype and Carbamazepine Dosing. CLINICAL PHARMACOLOGY & THERAPEUTICS, 94(3), 324-328. doi:10.1038/clpt.2013.103

DOI
10.1038/clpt.2013.103
Journal article

Anticonvuls ant Agents

Pirmohamed, M., & Leeder, J. S. (2013). Anticonvuls ant Agents. In DRUG-INDUCED LIVER DISEASE, 3RD EDITION (pp. 423-441). doi:10.1016/B978-0-12-387817-5.00024-8

DOI
10.1016/B978-0-12-387817-5.00024-8
Chapter

Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives

Farrell, J., Lichtenfels, M., Sullivan, A., Elliott, E. C., Alfirevic, A., Stachulski, A. V., . . . Park, B. K. (2013). Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives. Journal of Allergy and Clinical Immunology, 132(2), 493-495. doi:10.1016/j.jaci.2013.02.045

DOI
10.1016/j.jaci.2013.02.045
Journal article

Comparative Effectiveness of Dabigatran, Rivaroxaban, Apixaban, and Warfarin in the Management of Patients With Nonvalvular Atrial Fibrillation

Pink, J., Pirmohamed, M., & Hughes, D. A. (2013). Comparative Effectiveness of Dabigatran, Rivaroxaban, Apixaban, and Warfarin in the Management of Patients With Nonvalvular Atrial Fibrillation. CLINICAL PHARMACOLOGY & THERAPEUTICS, 94(2), 269-276. doi:10.1038/clpt.2013.83

DOI
10.1038/clpt.2013.83
Journal article

Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFNβ interact with the endogenous cytokine and activate complement

Sethu, S., Govindappa, K., Quinn, P., Wadhwa, M., Stebbings, R., Boggild, M., . . . Sathish, J. (2013). Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFNβ interact with the endogenous cytokine and activate complement. CLINICAL IMMUNOLOGY, 148(2), 177-185. doi:10.1016/j.clim.2013.05.008

DOI
10.1016/j.clim.2013.05.008
Journal article

The International Serious Adverse Events Consortium (iSAEC) phenotype standardization project for drug-induced torsades de pointes

Behr, E. R., January, C., Schulze-Bahr, E., Grace, A. A., Kaeaeb, S., Fiszman, M., . . . Roden, D. (2013). The International Serious Adverse Events Consortium (iSAEC) phenotype standardization project for drug-induced torsades de pointes. EUROPEAN HEART JOURNAL, 34(26), 1958-1963. doi:10.1093/eurheartj/ehs172

DOI
10.1093/eurheartj/ehs172
Journal article

Immunomodulatory interventions for focal epilepsy syndromes

Walker, L., Pirmohamed, M., & Marson, A. G. (2013). Immunomodulatory interventions for focal epilepsy syndromes. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (6). doi:10.1002/14651858.CD009945.pub2

DOI
10.1002/14651858.CD009945.pub2
Journal article

β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis

Jenkins, R. E., Yaseen, F. S., Monshi, M. M., Whitaker, P., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2013). β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis. CHEMICAL RESEARCH IN TOXICOLOGY, 26(6), 963-975. doi:10.1021/tx400124m

DOI
10.1021/tx400124m
Journal article

ABCB1 single nucleotide polymorphisms (1236C &gt; T, 2677G &gt; T, and 3435C &gt; T) do not affect transport activity of human P-glycoprotein

Dickens, D., Owen, A., Alfirevic, A., & Pirmohamed, M. (2013). ABCB1 single nucleotide polymorphisms (1236C &gt; T, 2677G &gt; T, and 3435C &gt; T) do not affect transport activity of human P-glycoprotein. PHARMACOGENETICS AND GENOMICS, 23(6), 314-323. doi:10.1097/FPC.0b013e328360d10c

DOI
10.1097/FPC.0b013e328360d10c
Journal article

Cost-effectiveness of pharmacogenetic-guided dosing of phenprocoumon in atrial fibrillation

Verhoef, T. I., Redekop, W. K., Veenstra, D. L., Thariani, R., Beltman, P. A., van Schie, R. M. F., . . . Maitland-van der Zee, A. -H. (2013). Cost-effectiveness of pharmacogenetic-guided dosing of phenprocoumon in atrial fibrillation. PHARMACOGENOMICS, 14(8), 869-883. doi:10.2217/PGS.13.74

DOI
10.2217/PGS.13.74
Journal article

Expanding Role of Pharmacogenomics in the Management of Cardiovascular Disorders

Yip, V. L. M., & Pirmohamed, M. (2013). Expanding Role of Pharmacogenomics in the Management of Cardiovascular Disorders. AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS, 13(3), 151-162. doi:10.1007/s40256-013-0024-5

DOI
10.1007/s40256-013-0024-5
Journal article

Stroke Pharmacogenetics

Walker, L. E., Stewart, A., & Pirmohamed, M. (2013). Stroke Pharmacogenetics. In Stroke Genetics (pp. 223-297). Springer London. doi:10.1007/978-0-85729-209-4_14

DOI
10.1007/978-0-85729-209-4_14
Chapter

Transport of gabapentin by LAT1 (SLC7A5)

Dickens, D., Webb, S. D., Antonyuk, S., Giannoudis, A., Owen, A., Raedisch, S., . . . Pirmohamed, M. (2013). Transport of gabapentin by LAT1 (SLC7A5). BIOCHEMICAL PHARMACOLOGY, 85(11), 1672-1683. doi:10.1016/j.bcp.2013.03.022

DOI
10.1016/j.bcp.2013.03.022
Journal article

Transport of gabapentin by LAT1 (SLC7A5)

Dickens, D., Webb, S. D., Antonyuk, S., Giannoudis, A., Owen, A., Rädisch, S., . . . Pirmohamed, M. (2013). Transport of gabapentin by LAT1 (SLC7A5). Biochemical Pharmacology, 85(11), 1672-1683. doi:10.1016/j.bcp.2013.03.022

DOI
10.1016/j.bcp.2013.03.022
Journal article

A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp

Dickens, D., Yusof, S. R., Abbott, N. J., Weksler, B., Romero, I. A., Couraud, P. -O., . . . Owen, A. (2013). A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp. PLOS ONE, 8(5). doi:10.1371/journal.pone.0064854

DOI
10.1371/journal.pone.0064854
Journal article

Variability of antibiotic prescribing in patients with chronic obstructive pulmonary disease exacerbations: a cohort study

Boggon, R., Hubbard, R., Smeeth, L., Gulliford, M., Cassell, J., Eaton, S., . . . van Staa, T. -P. (2013). Variability of antibiotic prescribing in patients with chronic obstructive pulmonary disease exacerbations: a cohort study. BMC PULMONARY MEDICINE, 13. doi:10.1186/1471-2466-13-32

DOI
10.1186/1471-2466-13-32
Journal article

T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms

Bell, C. C., Faulkner, L., Martinsson, K., Farrell, J., Alfirevic, A., Tugwood, J., . . . Park, B. K. (2013). T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms. CHEMICAL RESEARCH IN TOXICOLOGY, 26(5), 759-766. doi:10.1021/tx400060p

DOI
10.1021/tx400060p
Journal article

T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms

Bell, C. C., Faulkner, L., Martinsson, K., Farrell, J., Alfirevic, A., Tugwood, J., . . . Park, B. K. (2013). T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms. Chemical Research in Toxicology, 26(5), 759-766. doi:10.1021/tx400060p

DOI
10.1021/tx400060p
Journal article

Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population

Carr, D. F., Chaponda, M., Jorgensen, A. L., Castro, E. C., van Oosterhout, J. J., Khoo, S. H., . . . Pirmohamed, M. (2013). Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population. CLINICAL INFECTIOUS DISEASES, 56(9), 1330-1339. doi:10.1093/cid/cit021

DOI
10.1093/cid/cit021
Journal article

Response to "HLA Allelic Variants and Carbamazepine-Induced Hypersensitivity"

Yip, V. L. M., Pirmohamed, M., & Alfirevic, A. (2013). Response to "HLA Allelic Variants and Carbamazepine-Induced Hypersensitivity". CLINICAL PHARMACOLOGY & THERAPEUTICS, 93(5), 387. doi:10.1038/clpt.2013.5

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10.1038/clpt.2013.5
Journal article

Response to "HLA allelic variants and carbamazepine-induced hypersensitivity".

Yip, V., Pirmohamed, M., & Alfirevic, A. (2013). Response to "HLA allelic variants and carbamazepine-induced hypersensitivity".. Clinical Pharmacology and Therapeutics, 93(5), 387.

Journal article

Challenges and approaches for the development of safer immunomodulatory biologics

Sathish, J. G., Sethu, S., Bielsky, M. -C., de Haan, L., French, N. S., Govindappa, K., . . . Park, B. K. (2013). Challenges and approaches for the development of safer immunomodulatory biologics. NATURE REVIEWS DRUG DISCOVERY, 12(4), 306-324. doi:10.1038/nrd3974

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10.1038/nrd3974
Journal article

LONG-TERM OUTCOMES OF PATIENTS WITH ALCOHOL-RELATED CIRRHOSIS ADMITTED TO A GENERAL INTENSIVE CARE UNIT AT A TERTIARY HOSPITAL IN THE UNITED KINGDOM

Musumba, C., Shaw, R., Gao, W., Richardson, P., & Hampshire, P. (2013). LONG-TERM OUTCOMES OF PATIENTS WITH ALCOHOL-RELATED CIRRHOSIS ADMITTED TO A GENERAL INTENSIVE CARE UNIT AT A TERTIARY HOSPITAL IN THE UNITED KINGDOM. In JOURNAL OF HEPATOLOGY Vol. 58 (pp. S224). doi:10.1016/S0168-8278(13)60550-4

DOI
10.1016/S0168-8278(13)60550-4
Conference Paper

What can we learn from parents about enhancing participation in pharmacovigilance?

Arnott, J., Hesselgreaves, H., Nunn, A. J., Peak, M., Pirmohamed, M., Smyth, R. L., . . . Young, B. (2013). What can we learn from parents about enhancing participation in pharmacovigilance?. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 75(4), 1109-1117. doi:10.1111/j.1365-2125.2012.04441.x

DOI
10.1111/j.1365-2125.2012.04441.x
Journal article

Paediatric pharmacogenomics: an overview

Hawcutt, D. B., Thompson, B., Smyth, R. L., & Pirmohamed, M. (2013). Paediatric pharmacogenomics: an overview. Archives of Disease in Childhood, 98(3), 232-237. doi:10.1136/archdischild-2012-302852

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10.1136/archdischild-2012-302852
Journal article

DRUG-GRAPEFRUIT JUICE INTERACTIONS A more balanced approach to drug-grapefruit juice interactions Reply

Pirmohamed, M. (2013). DRUG-GRAPEFRUIT JUICE INTERACTIONS A more balanced approach to drug-grapefruit juice interactions Reply. BMJ-BRITISH MEDICAL JOURNAL, 346. doi:10.1136/bmj.f1078

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10.1136/bmj.f1078
Journal article

<i>CYP2C19*17</i> Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease

Musumba, C. O., Jorgensen, A., Sutton, L., Van Eker, D., Zhang, E., O'Hara, N., . . . Pirmohamed, M. (2013). <i>CYP2C19*17</i> Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease. CLINICAL PHARMACOLOGY & THERAPEUTICS, 93(2), 195-203. doi:10.1038/clpt.2012.215

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10.1038/clpt.2012.215
Journal article

Human Leukocyte Antigen (HLA)-B<SUP>☆</SUP>57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury

Monshi, M. M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2013). Human Leukocyte Antigen (HLA)-B<SUP>☆</SUP>57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury. HEPATOLOGY, 57(2), 727-739. doi:10.1002/hep.26077

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10.1002/hep.26077
Journal article

The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia

Giannoudis, A., Wang, L., Jorgensen, A. L., Xinarianos, G., Davies, A., Pushpakom, S., . . . Clark, R. E. (2013). The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia. BLOOD, 121(4), 628-637. doi:10.1182/blood-2012-01-405035

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10.1182/blood-2012-01-405035
Journal article

Drug-grapefruit juice interactions

Pirmohamed, M. (2013). Drug-grapefruit juice interactions. BMJ-BRITISH MEDICAL JOURNAL, 346. doi:10.1136/bmj.f1

DOI
10.1136/bmj.f1
Journal article

A Randomized Trial Comparing Genotype-Guided Dosing of Warfarin to Standard Dosing: The EU Pharmacogenetics of Anticoagulant Therapy (EU-PACT) Warfarin Study

Pirmohamed, M., Burnside, G., Stoddern, J., Prince, C., Toh, C. H., Nicholson, T., . . . Wadelius, M. (2013). A Randomized Trial Comparing Genotype-Guided Dosing of Warfarin to Standard Dosing: The EU Pharmacogenetics of Anticoagulant Therapy (EU-PACT) Warfarin Study. CIRCULATION, 128(24), 2710-2711. Retrieved from https://www.webofscience.com/

Journal article

A multi-system approach assessing the interaction of anticonvulsants with P-gp.

Dickens, D., Yusof, S. R., Abbott, N. J., Weksler, B., Romero, I. A., Couraud, P. -O., . . . Owen, A. (2013). A multi-system approach assessing the interaction of anticonvulsants with P-gp.. PloS One, 8(5), e64854.

Journal article

Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives

Farrell, J., Lichtenfels, M., Sullivan, A., Elliott, E. C., Alfirevic, A., Stachulski, A. V., . . . Park, B. K. (2013). Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132(2), 493-495. doi:10.1016/j.jaci.2013.02.045

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10.1016/j.jaci.2013.02.045
Journal article

Adherence and variability in warfarin dose requirements: assessment in a prospective cohort

Jorgensen, A. L., Hughes, D. A., Hanson, A., van Eker, D., Toh, C. H., Pirmohamed, M., & Williamson, P. R. (2013). Adherence and variability in warfarin dose requirements: assessment in a prospective cohort. PHARMACOGENOMICS, 14(2), 151-163. doi:10.2217/PGS.12.199

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10.2217/PGS.12.199
Journal article

Defining the role of MicroRNA-122 as a potential circulating biomarker for liver injury and disease

McWhirter, D., Lewis, P. S., Kitteringham, N., Antoine, D., Pirmohamed, M., Goldring, C., . . . Malik, H. (2013). Defining the role of MicroRNA-122 as a potential circulating biomarker for liver injury and disease. BRITISH JOURNAL OF SURGERY, 100, 15-16. Retrieved from https://www.webofscience.com/

Journal article

Emergence and global spread of epidemic healthcare-associated <i>Clostridium difficile</i>

He, M., Miyajima, F., Roberts, P., Ellison, L., Pickard, D. J., Martin, M. J., . . . Lawley, T. D. (2013). Emergence and global spread of epidemic healthcare-associated <i>Clostridium difficile</i>. NATURE GENETICS, 45(1), 109-U155. doi:10.1038/ng.2478

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10.1038/ng.2478
Journal article

Paediatric use of mycophenolate mofetil

Downing, H. J., Pirmohamed, M., Beresford, M. W., & Smyth, R. L. (2013). Paediatric use of mycophenolate mofetil. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 75(1), 45-59. doi:10.1111/j.1365-2125.2012.04305.x

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10.1111/j.1365-2125.2012.04305.x
Journal article

Paediatric use of mycophenolate mofetil

Downing, H. J., Pirmohamed, M., Beresford, M. W., & Smyth, R. L. (2013). Paediatric use of mycophenolate mofetil. British Journal of Clinical Pharmacology, 75(1), 45-59. doi:10.1111/j.1365-2125.2012.04305.x

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10.1111/j.1365-2125.2012.04305.x
Journal article

Pharmacogenetic analysis of CYP2B6 in the LRF CLL4 trial: the*6 allelic variant is associated with inferior efficacy following fludarabine plus cyclophosphamide

Johnson, G. G., Lin, K., Cox, T., Oates, M., Sibson, D. R., Eccles, R., . . . Pettitt, A. R. (2013). Pharmacogenetic analysis of CYP2B6 in the LRF CLL4 trial: the*6 allelic variant is associated with inferior efficacy following fludarabine plus cyclophosphamide. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 161 (pp. 19). Retrieved from https://www.webofscience.com/

Conference Paper

Pharmacogenetic tests: the need for a level playing field

Pirmohamed, M., & Hughes, D. A. (2013). Pharmacogenetic tests: the need for a level playing field. NATURE REVIEWS DRUG DISCOVERY, 12(1), 3-4. doi:10.1038/nrd3921

DOI
10.1038/nrd3921
Journal article

Pharmacogenomics of anaphylaxis to neuromuscular blocking agents

Fisher, A., Leuwer, M., & Pirmohamed, M. (2013). Pharmacogenomics of anaphylaxis to neuromuscular blocking agents. In BRITISH JOURNAL OF ANAESTHESIA Vol. 110 (pp. 865). Retrieved from https://www.webofscience.com/

Conference Paper

Role of IL18 in HIV lipodystrophy

Majid, R., Pushpakom, S., & Pirmohamed, M. (2013). Role of IL18 in HIV lipodystrophy. In HIV MEDICINE Vol. 14 (pp. 40). Retrieved from https://www.webofscience.com/

Conference Paper

Systematic review of pharmacogenomics in psoriasis

Foulkes, A. C., Jorgensen, A., Pirmohamed, M., Griffiths, C. E., & Warren, R. B. (2013). Systematic review of pharmacogenomics in psoriasis. In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 133 (pp. S88). Retrieved from https://www.webofscience.com/

Conference Paper

TRANSCRIPT LEVELS AND COPY NUMBER VARIATION OF THE ABCC3 EFFLUX TRANSPORTER CAN PREDICT CLINICAL OUTCOME IN IMATINIB-TREATED CHRONIC MYELOID LEUKAEMIA PATIENTS

Giannoudis, A., Davies, A., Harris, R., Lucas, C., Pirmohamed, M., & Clark, R. (2013). TRANSCRIPT LEVELS AND COPY NUMBER VARIATION OF THE ABCC3 EFFLUX TRANSPORTER CAN PREDICT CLINICAL OUTCOME IN IMATINIB-TREATED CHRONIC MYELOID LEUKAEMIA PATIENTS. In HAEMATOLOGICA Vol. 98 (pp. 400). Retrieved from https://www.webofscience.com/

Conference Paper

The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK

Alfirevic, A., Carr, D. F., Miyajima, F., Pushpakom, S., Sutton, L., Jorgensen, A. L., & Pirmohamed, M. (2013). The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK. PHARMACOGENOMICS, 14(8), 861-867. doi:10.2217/PGS.13.73

DOI
10.2217/PGS.13.73
Journal article

The hOCT1 single nucleotide polymorphisms M420del and M408V alter imatinib uptake and modify clinical outcome in imatinib treated chronic myeloid leukaemia

Giannoudis, A., Wang, L., Jorgensen, A. L., Xinarianos, G., Davies, A., Pushpakom, S., . . . Clark, R. E. (2013). The hOCT1 single nucleotide polymorphisms M420del and M408V alter imatinib uptake and modify clinical outcome in imatinib treated chronic myeloid leukaemia. Blood, 121, 628-637.

Journal article

The hOCT1 substrate metformin does not alter imatinib, dasatinib or nilotinib uptake into CML cells at clinically relevant concentrations

Francis, S., Giannoudis, A., Pirmohamed, M., & Clark, R. E. (2013). The hOCT1 substrate metformin does not alter imatinib, dasatinib or nilotinib uptake into CML cells at clinically relevant concentrations. BRITISH JOURNAL OF HAEMATOLOGY, 161, 58-59. Retrieved from https://www.webofscience.com/

Journal article

Transport of gabapentin by LAT1 (SLC7A5)

Dickens,, D., Webb,, S. D., Antonyuk,, S., Giannoudis,, A., Owen,, A., Rädisch,, S., . . . Pirmohamed,, M. (2013). Transport of gabapentin by LAT1 (SLC7A5). Biochemical Pharmacology, 85, 1672-1683.

Journal article

2012

Improved Glycaemia Correlates with Liver Fat Reduction in Obese, Type 2 Diabetes, Patients Given Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists

Cuthbertson, D. J., Irwin, A., Gardner, C. J., Daousi, C., Purewal, T., Furlong, N., . . . Kemp, G. J. (2012). Improved Glycaemia Correlates with Liver Fat Reduction in Obese, Type 2 Diabetes, Patients Given Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists. PLOS ONE, 7(12). doi:10.1371/journal.pone.0050117

DOI
10.1371/journal.pone.0050117
Journal article

Adverse Drug Reactions Causing Admission to a Paediatric Hospital

Gallagher, R. M., Mason, J. R., Bird, K. A., Kirkham, J. J., Peak, M., Williamson, P. R., . . . Smyth, R. L. (2012). Adverse Drug Reactions Causing Admission to a Paediatric Hospital. PLOS ONE, 7(12). doi:10.1371/journal.pone.0050127

DOI
10.1371/journal.pone.0050127
Journal article

HLA Genotype and Carbamazepine-Induced Cutaneous Adverse Drug Reactions: A Systematic Review

Yip, V. L., Marson, A. G., Jorgensen, A. L., Pirmohamed, M., & Alfirevic, A. (2012). HLA Genotype and Carbamazepine-Induced Cutaneous Adverse Drug Reactions: A Systematic Review. CLINICAL PHARMACOLOGY & THERAPEUTICS, 92(6), 757-765. doi:10.1038/clpt.2012.189

DOI
10.1038/clpt.2012.189
Journal article

HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review.

Yip, V., Marson, T., Jorgensen, A., Pirmohamed, M., & Alfirevic, A. (2012). HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review.. Clinical Pharmacology and Therapeutics, 92(6), 757-765.

Journal article

Impact of the <i>CYP4F2</i> p.V433M Polymorphism on Coumarin Dose Requirement: Systematic Review and Meta-Analysis

Danese, E., Montagnana, M., Johnson, J. A., Rettie, A. E., Zambon, C. F., Lubitz, S. A., . . . Fava, C. (2012). Impact of the <i>CYP4F2</i> p.V433M Polymorphism on Coumarin Dose Requirement: Systematic Review and Meta-Analysis. CLINICAL PHARMACOLOGY & THERAPEUTICS, 92(6), 746-756. doi:10.1038/clpt.2012.184

DOI
10.1038/clpt.2012.184
Journal article

Long-term anticoagulant effects of CYP2C9 and VKORC1 genotypes in phenprocoumon users

Verhoef, T. I., Redekop, W. K., Hegazy, H., de Boer, A., & Maitland-van der Zee, A. H. (2012). Long-term anticoagulant effects of CYP2C9 and VKORC1 genotypes in phenprocoumon users. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 10(12), 2610-2612. doi:10.1111/jth.12007

DOI
10.1111/jth.12007
Journal article

VARIATION AT GLCCI1: ASSOCIATION WITH INCREASED STEROID DOSE BUT NOT ADRENAL SUPPRESSION IN ASTHMATIC CHILDREN

Thompson, B., Hawcutt, D. B., Carr, D. F., Jorgensen, A. L., Smyth, R. L., & Pirmohamed, M. (2012). VARIATION AT GLCCI1: ASSOCIATION WITH INCREASED STEROID DOSE BUT NOT ADRENAL SUPPRESSION IN ASTHMATIC CHILDREN. THORAX, 67, A17. doi:10.1136/thoraxjnl-2012-202678.037

DOI
10.1136/thoraxjnl-2012-202678.037
Journal article

Explanation for <i>HLA</i>-<i>B</i>*<i>57</i>:<i>01</i>-linked immune-mediated abacavir-induced hypersensitivity

Alfirevic, A., Park, B. K., Pirmohamed, M., & Naisbitt, D. J. (2012). Explanation for <i>HLA</i>-<i>B</i>*<i>57</i>:<i>01</i>-linked immune-mediated abacavir-induced hypersensitivity. PHARMACOGENOMICS, 13(14), 1567-1569. doi:10.2217/PGS.12.146

DOI
10.2217/PGS.12.146
Journal article

Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs

Urban, T. J., Shen, Y., Stolz, A., Chalasani, N., Fontana, R. J., Rochon, J., . . . Watkins, P. B. (2012). Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs. PHARMACOGENETICS AND GENOMICS, 22(11), 784-795. doi:10.1097/FPC.0b013e3283589a76

DOI
10.1097/FPC.0b013e3283589a76
Journal article

Enhancing Communication about Paediatric Medicines: Lessons from a Qualitative Study of Parents' Experiences of Their Child's Suspected Adverse Drug Reaction

Arnott, J., Hesselgreaves, H., Nunn, A. J., Peak, M., Pirmohamed, M., Smyth, R. L., . . . Young, B. (2012). Enhancing Communication about Paediatric Medicines: Lessons from a Qualitative Study of Parents' Experiences of Their Child's Suspected Adverse Drug Reaction. PLOS ONE, 7(10). doi:10.1371/journal.pone.0046022

DOI
10.1371/journal.pone.0046022
Journal article

Immunogenicity to Biologics: Mechanisms, Prediction and Reduction

Sethu, S., Govindappa, K., Alhaidari, M., Pirmohamed, M., Park, K., & Sathish, J. (2012). Immunogenicity to Biologics: Mechanisms, Prediction and Reduction. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 60(5), 331-344. doi:10.1007/s00005-012-0189-7

DOI
10.1007/s00005-012-0189-7
Journal article

Cost-effectiveness of pharmacogenetics in anticoagulation: international differences in healthcare systems and costs

Verhoef, T. I., Redekop, W. K., van Schie, R. M. F., Bayat, S., Daly, A. K., Geitona, M., . . . Maitland-van der Zee, A. -H. (2012). Cost-effectiveness of pharmacogenetics in anticoagulation: international differences in healthcare systems and costs. PHARMACOGENOMICS, 13(12), 1405-1417. doi:10.2217/PGS.12.124

DOI
10.2217/PGS.12.124
Journal article

Letter: are idiopathic (non-NSAID, non-Helicobacter pylori) ulcers really increasing? Authors' reply

Musumba, C., Hopkins, M., Pritchard, D. M., & Pirmohamed, M. (2012). Letter: are idiopathic (non-NSAID, non-Helicobacter pylori) ulcers really increasing? Authors' reply. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 36(6), 601-602. doi:10.1111/apt.12001

DOI
10.1111/apt.12001
Journal article

Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical Utility

Alfirevic, A., & Pirmohamed, M. (2012). Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical Utility. CLINICAL PHARMACOLOGY & THERAPEUTICS, 92(3), 376-380. doi:10.1038/clpt.2012.107

DOI
10.1038/clpt.2012.107
Journal article

Influence of CYP2C9 and VKORC1 on Patient Response to Warfarin: A Systematic Review and Meta-Analysis

Jorgensen, A. L., FitzGerald, R. J., Oyee, J., Pirmohamed, M., & Williamson, P. R. (2012). Influence of CYP2C9 and VKORC1 on Patient Response to Warfarin: A Systematic Review and Meta-Analysis. PLOS ONE, 7(8). doi:10.1371/journal.pone.0044064

DOI
10.1371/journal.pone.0044064
Journal article

Mechanism-Based Urinary Biomarkers to Identify the Potential for Aminoglycoside-Induced Nephrotoxicity in Premature Neonates: A Proof-of-Concept Study

McWilliam, S. J., Antoine, D. J., Sabbisetti, V., Turner, M. A., Farragher, T., Bonventre, J. V., . . . Pirmohamed, M. (2012). Mechanism-Based Urinary Biomarkers to Identify the Potential for Aminoglycoside-Induced Nephrotoxicity in Premature Neonates: A Proof-of-Concept Study. PLOS ONE, 7(8). doi:10.1371/journal.pone.0043809

DOI
10.1371/journal.pone.0043809
Journal article

General pharmacology

Schachter, M., & Pirmohamed, M. (2012). General pharmacology. In Clinical Pharmacology (pp. 74-109). Elsevier. doi:10.1016/b978-0-7020-4084-9.00047-1

DOI
10.1016/b978-0-7020-4084-9.00047-1
Chapter

Commentary: changing aetiology of peptic ulcers - author's reply

Musumba, C., Pritchard, D. M., & Pirmohamed, M. (2012). Commentary: changing aetiology of peptic ulcers - author's reply. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 36(3), 292-293. doi:10.1111/j.1365-2036.2012.05176.x

DOI
10.1111/j.1365-2036.2012.05176.x
Journal article

CYP2C19*17 GAIN OF FUNCTION MUTATION IS ASSOCIATED WITH PEPTIC ULCER DISEASE

Musumba, C. O., Eker, D. V., Jorgensen, A., Pritchard, D. M., & Pirmohamed, M. (2012). CYP2C19*17 GAIN OF FUNCTION MUTATION IS ASSOCIATED WITH PEPTIC ULCER DISEASE. GUT, 61, A363. doi:10.1136/gutjnl-2012-302514d.165

DOI
10.1136/gutjnl-2012-302514d.165
Journal article

<i>In silico</i> analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers

Alfirevic, A., Gonzalez-Galarza, F., Bell, C., Martinsson, K., Platt, V., Bretland, G., . . . Pirmohamed, M. (2012). <i>In silico</i> analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers. GENOME MEDICINE, 4. doi:10.1186/gm350

DOI
10.1186/gm350
Journal article

Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis

El-Ghaiesh, S., Monshi, M. M., Whitaker, P., Jenkins, R., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 341(3), 597-610. doi:10.1124/jpet.111.190900

DOI
10.1124/jpet.111.190900
Journal article

An evaluation of gene-gene interaction between the CYP2C9 and VKORC1 genotypes affecting the anticoagulant effect of phenprocoumon and acenocoumarol

Van Schie, R. M. F., Babajeff, A. M. V., Schalekamp, T., Wessels, J. A. M., Le Cessie, S., De Boer, A., . . . Maitland-Van der Zee, A. H. (2012). An evaluation of gene-gene interaction between the CYP2C9 and VKORC1 genotypes affecting the anticoagulant effect of phenprocoumon and acenocoumarol. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 10(5), 767-772. doi:10.1111/j.1538-7836.2012.04694.x

DOI
10.1111/j.1538-7836.2012.04694.x
Journal article

Genetics and the Potential for Predictive Tests in Adverse Drug Reactions

Pirmohamed, M. (2012). Genetics and the Potential for Predictive Tests in Adverse Drug Reactions. ADVERSE CUTANEOUS DRUG ERUPTIONS, 97, 18-31. Retrieved from https://www.webofscience.com/

Journal article

Pharmacogenetics of Adverse Drug Reactions

Daly, A. K., Armstrong, M., & Pirmohamed, M. (2012). Pharmacogenetics of Adverse Drug Reactions. In Unknown Book (pp. 295-321). Wiley. doi:10.1002/9781118116494.ch10

DOI
10.1002/9781118116494.ch10
Chapter

Clinical Pharmacogenetics Implementation Consortium Guidelines for <i>HLA</i>-<i>B</i> Genotype and Abacavir Dosing

Martin, M. A., Klein, T. E., Dong, B. J., Pirmohamed, M., Haas, D. W., & Kroetz, D. L. (2012). Clinical Pharmacogenetics Implementation Consortium Guidelines for <i>HLA</i>-<i>B</i> Genotype and Abacavir Dosing. CLINICAL PHARMACOLOGY & THERAPEUTICS, 91(4), 734-738. doi:10.1038/clpt.2011.355

DOI
10.1038/clpt.2011.355
Journal article

Genome-wide association study of serious blistering skin rash caused by drugs

Shen, Y., Nicoletti, P., Floratos, A., Pirmohamed, M., Molokhia, M., Geppetti, P., . . . Pe'er, I. (2012). Genome-wide association study of serious blistering skin rash caused by drugs. PHARMACOGENOMICS JOURNAL, 12(2), 96-104. doi:10.1038/tpj.2010.84

DOI
10.1038/tpj.2010.84
Journal article

Long-term anticoagulant effects of the CYP2C9 and VKORC1 genotypes in acenocoumarol users

Verhoef, T. I., Redekop, W. K., Buikema, M. M., Schalekamp, T., van der Meer, F. J. M., Le Cessie, S., . . . Maitland-van der Zee, A. H. (2012). Long-term anticoagulant effects of the CYP2C9 and VKORC1 genotypes in acenocoumarol users. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 10(4), 606-614. doi:10.1111/j.1538-7836.2012.04633.x

DOI
10.1111/j.1538-7836.2012.04633.x
Journal article

Lamotrigine is a substrate for OCT1 in brain endothelial cells

Dickens, D., Owen, A., Alfirevic, A., Giannoudis, A., Davies, A., Weksler, B., . . . Pirmohamed, M. (2012). Lamotrigine is a substrate for OCT1 in brain endothelial cells. BIOCHEMICAL PHARMACOLOGY, 83(6), 805-814. doi:10.1016/j.bcp.2011.12.032

DOI
10.1016/j.bcp.2011.12.032
Journal article

EXPLORING THE GENETIC BASIS OF PHARMACORESISTANCE IN EPILEPSY: AN INTEGRATIVE ANALYSIS OF LARGE-SCALE GENE EXPRESSION PROFILING STUDIES ON BRAIN TISSUE FROM EPILEPSY SURGERY

Mirza, N., Vasieva, O., Marson, A. G., & Pirmohamed, M. (2012). EXPLORING THE GENETIC BASIS OF PHARMACORESISTANCE IN EPILEPSY: AN INTEGRATIVE ANALYSIS OF LARGE-SCALE GENE EXPRESSION PROFILING STUDIES ON BRAIN TISSUE FROM EPILEPSY SURGERY. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 83(3). doi:10.1136/jnnp-2011-301993.94

DOI
10.1136/jnnp-2011-301993.94
Journal article

Release of intracellular calcium primes chronic myeloid leukaemia cells for tyrosine kinase inhibitor-induced apoptosis

Forchap, S. L., Pirmohamed, M., & Clark, R. E. (2012). Release of intracellular calcium primes chronic myeloid leukaemia cells for tyrosine kinase inhibitor-induced apoptosis. LEUKEMIA, 26(3), 490-498. doi:10.1038/leu.2011.231

DOI
10.1038/leu.2011.231
Journal article

Reported paediatric adverse drug reactions in the UK 2000-2009

Hawcutt, D. B., Mainie, P., Riordan, A., Smyth, R. L., & Pirmohamed, M. (2012). Reported paediatric adverse drug reactions in the UK 2000-2009. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 73(3), 437-446. doi:10.1111/j.1365-2125.2011.04113.x

DOI
10.1111/j.1365-2125.2011.04113.x
Journal article

Pharmacogenetic warfarin dose refinements remain significantly influenced by genetic factors after one week of therapy

Horne, B. D., Lenzini, P. A., Wadelius, M., Jorgensen, A. L., Kimmel, S. E., Ridker, P. M., . . . Gage, B. F. (2012). Pharmacogenetic warfarin dose refinements remain significantly influenced by genetic factors after one week of therapy. THROMBOSIS AND HAEMOSTASIS, 107(2), 232-240. doi:10.1160/TH11-06-0388

DOI
10.1160/TH11-06-0388
Journal article

Pragmatic randomised trials using routine electronic health records: putting them to the test

van Staa, T. -P., Goldacre, B., Gulliford, M., Cassell, J., Pirmohamed, M., Taweel, A., . . . Smeeth, L. (2012). Pragmatic randomised trials using routine electronic health records: putting them to the test. BMJ-BRITISH MEDICAL JOURNAL, 344. doi:10.1136/bmj.e55

DOI
10.1136/bmj.e55
Journal article

Association of <i>ABCC10</i> polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS

Liptrott, N. J., Pushpakom, S., Wyen, C., Faetkenheuer, G., Hoffmann, C., Mauss, S., . . . Owen, A. (2012). Association of <i>ABCC10</i> polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS. PHARMACOGENETICS AND GENOMICS, 22(1), 10-19. doi:10.1097/FPC.0b013e32834dd82e

DOI
10.1097/FPC.0b013e32834dd82e
Journal article

Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS

Liptrott, N. J., Pushpakom, S., Wyen, C., Fätkenheuer, G., Hoffmann, C., Mauss, S., . . . Owen, A. (2012). Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS. Pharmacogenetics and Genomics, 22(1), 10-19. doi:10.1097/fpc.0b013e32834dd82e

DOI
10.1097/fpc.0b013e32834dd82e
Journal article

CYP2C19*17 Gain of Function Mutation is Associated With the Development of Peptic Ulcer Disease

Musumba, C. O., Van Eker, D., Jorgensen, A. L., Zhang, E., O'Hara, N., Pritchard, M., & Pirmohamed, M. (2012). CYP2C19*17 Gain of Function Mutation is Associated With the Development of Peptic Ulcer Disease. In GASTROENTEROLOGY Vol. 142 (pp. S502). Retrieved from https://www.webofscience.com/

Conference Paper

Characterisation of antidrug antibodies (ADA) against therapeutic interferon beta

Govindappa, K., Sethu, S., Wadwa, M., Stebbings, R., Kimber, I., Naisbitt, D. J., . . . Sathish, J. G. (2012). Characterisation of antidrug antibodies (ADA) against therapeutic interferon beta. In IMMUNOLOGY Vol. 137 (pp. 655-656). Retrieved from https://www.webofscience.com/

Conference Paper

HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury

Monshi, M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2012). HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury. Hepatology.

Journal article

INVESTIGATION OF ANTIEPILEPTIC DRUG TRANSPORT BY SOLUTE CARRIERS OATP1A2 AND MCT1

Jones, H. L., Dickens, D., Owen, A., Pirmohamed, M., & Sills, G. J. (2012). INVESTIGATION OF ANTIEPILEPTIC DRUG TRANSPORT BY SOLUTE CARRIERS OATP1A2 AND MCT1. In EPILEPSIA Vol. 53 (pp. 101). Retrieved from https://www.webofscience.com/

Conference Paper

Impact of the CYP4F2 p.V433M polymorphism on coumarin dose requirement: systematic review and meta-analysis

Danese, E., Montagnana, M., Johnson, J. A., Rettie, A. E., Zambon, C. F., Lubitz, S. A., . . . Fava, C. (2012). Impact of the CYP4F2 p.V433M polymorphism on coumarin dose requirement: systematic review and meta-analysis. Clin Pharmacol Ther, 92(6), 746-756. doi:10.1038/clpt.2012.184

DOI
10.1038/clpt.2012.184
Journal article

Off-label and unlicensed medicine use and adverse drug reactions in children: a narrative review of the literature

Mason, J., Pirmohamed, M., & Nunn, T. (2012). Off-label and unlicensed medicine use and adverse drug reactions in children: a narrative review of the literature. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 68(1), 21-28. doi:10.1007/s00228-011-1097-1

DOI
10.1007/s00228-011-1097-1
Journal article

Parents' experiences of adverse drug reations in children: qualitative study

Arnott, J., Turner, M. A., Hesselgreave, H., Nunn, A. J., Peak, M., Pirmohamed, M., . . . Young, B. (2012). Parents' experiences of adverse drug reations in children: qualitative study. In PHARMACOEPIDEMIOLOGY AND DRUG SAFETY Vol. 21 (pp. 112). Retrieved from https://www.webofscience.com/

Conference Paper

Pharmacogenetics for the prescriber

Pirmohamed, M. (2012). Pharmacogenetics for the prescriber. Medicine, 40(7), 362-365. doi:10.1016/j.mpmed.2012.04.005

DOI
10.1016/j.mpmed.2012.04.005
Journal article

Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal

Alfirevic, A., McCormack, M., Pirmohamed, M., & Cavalleri, G. L. (2012). Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal. BRITISH JOURNAL OF DERMATOLOGY, 166(1), 12-14. doi:10.1111/j.1365-2133.2011.10760.x

DOI
10.1111/j.1365-2133.2011.10760.x
Journal article

The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors

Lane, S., Al-Zubiedi, S., Hatch, E., Matthews, I., Jorgensen, A. L., Deloukas, P., . . . Pirmohamed, M. (2012). The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 73(1), 66-76. doi:10.1111/j.1365-2125.2011.04051.x

DOI
10.1111/j.1365-2125.2011.04051.x
Journal article

The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010

Musumba, C., Jorgensen, A., Sutton, L., Van Eker, D., Moorcroft, J., Hopkins, M., . . . Pirmohamed, M. (2012). The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 36(1), 48-56. doi:10.1111/j.1365-2036.2012.05118.x

DOI
10.1111/j.1365-2036.2012.05118.x
Journal article

2011

Development and Inter-Rater Reliability of the Liverpool Adverse Drug Reaction Causality Assessment Tool

Gallagher, R. M., Kirkham, J. J., Mason, J. R., Bird, K. A., Williamson, P. R., Nunn, A. J., . . . Pirmohamed, M. (2011). Development and Inter-Rater Reliability of the Liverpool Adverse Drug Reaction Causality Assessment Tool. PLOS ONE, 6(12). doi:10.1371/journal.pone.0028096

DOI
10.1371/journal.pone.0028096
Journal article

DABIGATRAN V WARFARIN Authors' reply to Zermansky and Khatib

Hughes, D. A., Pink, J., Lane, S., & Pirmohamed, M. (2011). DABIGATRAN V WARFARIN Authors' reply to Zermansky and Khatib. BRITISH MEDICAL JOURNAL, 343. doi:10.1136/bmj.d7718

DOI
10.1136/bmj.d7718
Journal article

Pharmacogenetics of Adverse Drug Reactions

Pushpakom, S. P., & Pirmohamed, M. (2011). Pharmacogenetics of Adverse Drug Reactions. In Unknown Book (pp. 121-156). Wiley. doi:10.1002/9780470975053.ch2

DOI
10.1002/9780470975053.ch2
Chapter

Establishment of an HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions

Bell, C., Martinsson, K., Faulkner, L., Alfirevic, A., French, N., Tugwood, J., . . . Park, B. K. (2011). Establishment of an HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions. TOXICOLOGY, 290(2-3), 132-133. doi:10.1016/j.tox.2011.09.057

DOI
10.1016/j.tox.2011.09.057
Journal article

Measurement of the urinary biomarker KIM-1 identifies the potential for aminoglycoside-induced nephrotoxicity in premature neonates

Antoine, D. J., McWilliam, S., Sabbisetti, V., Turner, M., Smyth, R., Pirmohamed, M., . . . Park, B. K. (2011). Measurement of the urinary biomarker KIM-1 identifies the potential for aminoglycoside-induced nephrotoxicity in premature neonates. In TOXICOLOGY Vol. 290 (pp. 107). doi:10.1016/j.tox.2011.09.015

DOI
10.1016/j.tox.2011.09.015
Conference Paper

Novel OCT1 and OCT2 genetic variations-Potential link to metformin associated vitamin B<sub>12</sub> deficiency during diabetes

Green, L. A., Antoine, D. J., Mills, T., Nicholls, G., Park, B. K., & Pirmohamed, M. (2011). Novel OCT1 and OCT2 genetic variations-Potential link to metformin associated vitamin B<sub>12</sub> deficiency during diabetes. In TOXICOLOGY Vol. 290 (pp. 143-144). doi:10.1016/j.tox.2011.09.074

DOI
10.1016/j.tox.2011.09.074
Conference Paper

Exploring the genomic basis of pharmacoresistance in epilepsy: an integrative analysis of large-scale gene expression profiling studies on brain tissue from epilepsy surgery

Mirza, N., Vasieva, O., Marson, A. G., & Pirmohamed, M. (2011). Exploring the genomic basis of pharmacoresistance in epilepsy: an integrative analysis of large-scale gene expression profiling studies on brain tissue from epilepsy surgery. HUMAN MOLECULAR GENETICS, 20(22), 4381-4394. doi:10.1093/hmg/ddr365

DOI
10.1093/hmg/ddr365
Journal article

A Proposal for an Individualized Pharmacogenetics-Based Warfarin Initiation Dose Regimen for Patients Commencing Anticoagulation Therapy

Avery, P. J., Jorgensen, A., Hamberg, A., Wadelius, M., Pirmohamed, M., & Kamali, F. (2011). A Proposal for an Individualized Pharmacogenetics-Based Warfarin Initiation Dose Regimen for Patients Commencing Anticoagulation Therapy. CLINICAL PHARMACOLOGY & THERAPEUTICS, 90(5), 701-706. doi:10.1038/clpt.2011.186

DOI
10.1038/clpt.2011.186
Journal article

Pharmacogenomics in neurology: Current state and future steps

Chan, A., Pirmohamed, M., & Comabella, M. (2011). Pharmacogenomics in neurology: Current state and future steps. ANNALS OF NEUROLOGY, 70(5), 684-697. doi:10.1002/ana.22502

DOI
10.1002/ana.22502
Journal article

URINARY KIM-1 AS A BIOMARKER OF AMINOGLYCOSIDE-INDUCED NEPHROTOXICITY IN PREMATURE NEONATES

McWilliam, S. J., Antoine, D. J., Turner, M., Sabbisetti, V., Bonventre, J. V., Park, B. K., . . . Pirmohamed, M. (2011). URINARY KIM-1 AS A BIOMARKER OF AMINOGLYCOSIDE-INDUCED NEPHROTOXICITY IN PREMATURE NEONATES. In PEDIATRIC RESEARCH Vol. 70 (pp. 107). doi:10.1038/pr.2011.332

DOI
10.1038/pr.2011.332
Conference Paper

Dabigatran etexilate versus warfarin in management of non-valvular atrial fibrillation in UK context: quantitative benefit-harm and economic analyses

Pink, J., Lane, S., Pirmohamed, M., & Hughes, D. A. (2011). Dabigatran etexilate versus warfarin in management of non-valvular atrial fibrillation in UK context: quantitative benefit-harm and economic analyses. BMJ-BRITISH MEDICAL JOURNAL, 343. doi:10.1136/bmj.d6333

DOI
10.1136/bmj.d6333
Journal article

Clinical Pharmacogenetics Implementation Consortium Guidelines for <i>CYP2C9</i> and <i>VKORC1</i> Genotypes and Warfarin Dosing

Johnson, J. A., Gong, L., Whirl-Carrillo, M., Gage, B. F., Scott, S. A., Stein, C. M., . . . Altman, R. B. (2011). Clinical Pharmacogenetics Implementation Consortium Guidelines for <i>CYP2C9</i> and <i>VKORC1</i> Genotypes and Warfarin Dosing. CLINICAL PHARMACOLOGY & THERAPEUTICS, 90(4), 625-629. doi:10.1038/clpt.2011.185

DOI
10.1038/clpt.2011.185
Journal article

Pharmacogenetics: past, present and future

Pirmohamed, M. (2011). Pharmacogenetics: past, present and future. DRUG DISCOVERY TODAY, 16(19-20), 852-861. doi:10.1016/j.drudis.2011.08.006

DOI
10.1016/j.drudis.2011.08.006
Journal article

Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients

Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. Journal of Pharmacology and Experimental Therapeutics, 338(3), 841-849. doi:10.1124/jpet.111.183871

DOI
10.1124/jpet.111.183871
Journal article

Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients

Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 338(3), 841-849. doi:10.1124/jpet.111.183871

DOI
10.1124/jpet.111.183871
Journal article

Characterisation and Carriage Ratio of <i>Clostridium difficile</i> Strains Isolated from a Community-Dwelling Elderly Population in the United Kingdom

Miyajima, F., Roberts, P., Swale, A., Price, V., Jones, M., Horan, M., . . . Pirmohamed, M. (2011). Characterisation and Carriage Ratio of <i>Clostridium difficile</i> Strains Isolated from a Community-Dwelling Elderly Population in the United Kingdom. PLOS ONE, 6(8). doi:10.1371/journal.pone.0022804

DOI
10.1371/journal.pone.0022804
Journal article

Early Deaths During Tuberculosis Treatment Are Associated With Depressed Innate Responses, Bacterial Infection, and Tuberculosis Progression

Waitt, C. J., Banda, N. P. K., White, S. A., Kampmann, B., Kumwenda, J., Heyderman, R. S., . . . Squire, S. B. (2011). Early Deaths During Tuberculosis Treatment Are Associated With Depressed Innate Responses, Bacterial Infection, and Tuberculosis Progression. JOURNAL OF INFECTIOUS DISEASES, 204(3), 358-362. doi:10.1093/infdis/jir265

DOI
10.1093/infdis/jir265
Journal article

Loading and maintenance dose algorithms for phenprocoumon and acenocoumarol using patient characteristics and pharmacogenetic data

van Schie, R. M. F., Wessels, J. A. M., le Cessie, S., de Boer, A., Schalekamp, T., van der Meer, F. J. M., . . . Maitland-van der Zee, A. -H. (2011). Loading and maintenance dose algorithms for phenprocoumon and acenocoumarol using patient characteristics and pharmacogenetic data. EUROPEAN HEART JOURNAL, 32(15), 1909-1917. doi:10.1093/eurheartj/ehr116

DOI
10.1093/eurheartj/ehr116
Journal article

A randomised controlled trial of extended brief intervention for alcohol dependent patients in an acute hospital setting (ADPAC)

Owens, L., Butcher, G., Gilmore, I., Kolamunnage-Dona, R., Oyee, J., Perkins, L., . . . Pirmohamed, M. (2011). A randomised controlled trial of extended brief intervention for alcohol dependent patients in an acute hospital setting (ADPAC). BMC PUBLIC HEALTH, 11. doi:10.1186/1471-2458-11-528

DOI
10.1186/1471-2458-11-528
Journal article

Brief Interventions in Dependent Drinkers: A Comparative Prospective Analysis in Two Hospitals

Cobain, K., Owens, L., Kolamunnage-Dona, R., Fitzgerald, R., Gilmore, I., & Pirmohamed, M. (2011). Brief Interventions in Dependent Drinkers: A Comparative Prospective Analysis in Two Hospitals. ALCOHOL AND ALCOHOLISM, 46(4), 434-440. doi:10.1093/alcalc/agr044

DOI
10.1093/alcalc/agr044
Journal article

Genetic Variants of <i>ABCC10</i>, a Novel Tenofovir Transporter, Are Associated With Kidney Tubular Dysfunction

Pushpakom, S. P., Liptrott, N. J., Rodriguez-Novoa, S., Labarga, P., Soriano, V., Albalater, M., . . . Owen, A. (2011). Genetic Variants of <i>ABCC10</i>, a Novel Tenofovir Transporter, Are Associated With Kidney Tubular Dysfunction. JOURNAL OF INFECTIOUS DISEASES, 204(1), 145-153. doi:10.1093/infdis/jir215

DOI
10.1093/infdis/jir215
Journal article

Genetic Variants of ABCC10, a Novel Tenofovir Transporter, Are Associated With Kidney Tubular Dysfunction

Pushpakom, S. P., Liptrott, N. J., Rodríguez-Nóvoa, S., Labarga, P., Soriano, V., Albalater, M., . . . Owen, A. (2011). Genetic Variants of ABCC10, a Novel Tenofovir Transporter, Are Associated With Kidney Tubular Dysfunction. The Journal of Infectious Diseases, 204(1), 145-153. doi:10.1093/infdis/jir215

DOI
10.1093/infdis/jir215
Journal article

Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis

Whitaker, P., Meng, X., Lavergne, S. N., El-Ghaiesh, S., Monshi, M., Earnshaw, C., . . . Park, B. K. (2011). Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis. JOURNAL OF IMMUNOLOGY, 187(1), 200-211. doi:10.4049/jimmunol.1100647

DOI
10.4049/jimmunol.1100647
Journal article

Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways

El-Ghaiesh, S., Sanderson, J. P., Farrell, J., Lavergne, S. N., Syn, W. -K., Pirmohamed, M., . . . Naisbitt, D. J. (2011). Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways. CHEMICAL RESEARCH IN TOXICOLOGY, 24(6), 791-793. doi:10.1021/tx2001256

DOI
10.1021/tx2001256
Journal article

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

Laverty, H. G., Benson, C., Cartwright, E. J., Cross, M. J., Garland, C., Hammond, T., . . . Valentin, J. P. (2011). How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?. BRITISH JOURNAL OF PHARMACOLOGY, 163(4), 675-693. doi:10.1111/j.1476-5381.2011.01255.x

DOI
10.1111/j.1476-5381.2011.01255.x
Journal article

Phenotype Standardization for Immune-Mediated Drug-Induced Skin Injury

Pirmohamed, M., Friedmann, P. S., Molokhia, M., Loke, Y. K., Smith, C., Phillips, E., . . . Shear, N. H. (2011). Phenotype Standardization for Immune-Mediated Drug-Induced Skin Injury. CLINICAL PHARMACOLOGY & THERAPEUTICS, 89(6), 896-901. doi:10.1038/clpt.2011.79

DOI
10.1038/clpt.2011.79
Journal article

The Phenotype Standardization Project: Improving Pharmacogenetic Studies of Serious Adverse Drug Reactions

Pirmohamed, M., Aithal, G. P., Behr, E., Daly, A., & Roden, D. (2011). The Phenotype Standardization Project: Improving Pharmacogenetic Studies of Serious Adverse Drug Reactions. CLINICAL PHARMACOLOGY & THERAPEUTICS, 89(6), 784-785. doi:10.1038/clpt.2011.30

DOI
10.1038/clpt.2011.30
Journal article

The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein

Vogler, M., Dickens, D., Dyer, M. J. S., Owen, A., Pirmohamed, M., & Cohen, G. M. (2011). The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 408(2), 344-349. doi:10.1016/j.bbrc.2011.04.043

DOI
10.1016/j.bbrc.2011.04.043
Journal article

Aspirin resistance: Effect of clinical, biochemical and genetic factors

FitzGerald, R., & Pirmohamed, M. (2011). Aspirin resistance: Effect of clinical, biochemical and genetic factors. PHARMACOLOGY & THERAPEUTICS, 130(2), 213-225. doi:10.1016/j.pharmthera.2011.01.011

DOI
10.1016/j.pharmthera.2011.01.011
Journal article

Hypersensitivity reactions to HIV therapy

Chaponda, M., & Pirmohamed, M. (2011). Hypersensitivity reactions to HIV therapy. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 71(5), 659-671. doi:10.1111/j.1365-2125.2010.03784.x

DOI
10.1111/j.1365-2125.2010.03784.x
Journal article

Metabolic acidosis with topiramate and zonisamide

Mirza, N. S., Alfirevic, A., Jorgensen, A., Marson, A. G., & Pirmohamed, M. (2011). Metabolic acidosis with topiramate and zonisamide. Pharmacogenetics and Genomics, 21(5), 297-302. doi:10.1097/fpc.0b013e3283441b95

DOI
10.1097/fpc.0b013e3283441b95
Journal article

Adverse drug reactions causing admission to a paediatric hospital: a pilot study

Gallagher, R. M., Bird, K. A., Mason, J. R., Peak, M., Williamson, P. R., Nunn, A. J., . . . Smyth, R. L. (2011). Adverse drug reactions causing admission to a paediatric hospital: a pilot study. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 36(2), 194-199. doi:10.1111/j.1365-2710.2010.01194.x

DOI
10.1111/j.1365-2710.2010.01194.x
Journal article

Adverse drug reactions causing admission to a paediatric hospital: a pilot study

Gallagher, R. M., Bird, K. A., Mason, J. R., Peak, M., Williamson, P. R., Nunn, A. J., . . . Smyth, R. L. (2011). Adverse drug reactions causing admission to a paediatric hospital: a pilot study. Journal of Clinical Pharmacy and Therapeutics, 36(2), 194-199. doi:10.1111/j.1365-2710.2010.01194.x

DOI
10.1111/j.1365-2710.2010.01194.x
Journal article

CHANGING TRENDS IN PEPTIC ULCER DISEASE: THE RISE OF NSAID-INDUCED AND FALL OF <i>H PYLORI</i>-INDUCED ULCERS

Musumba, C. O., Van Eker, D., Jorgensen, A., Pritchard, M., & Pirmohamed, M. (2011). CHANGING TRENDS IN PEPTIC ULCER DISEASE: THE RISE OF NSAID-INDUCED AND FALL OF <i>H PYLORI</i>-INDUCED ULCERS. In GUT Vol. 60. doi:10.1136/gut.2011.239301.219

DOI
10.1136/gut.2011.239301.219
Conference Paper

HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans

McCormack, M., Alfirevic, A., Bourgeois, S., Farrell, J. J., Kasperaviciute, D., Carrington, M., . . . Pirmohamed, M. (2011). HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans. NEW ENGLAND JOURNAL OF MEDICINE, 364(12), 1134-1143. doi:10.1056/NEJMoa1013297

DOI
10.1056/NEJMoa1013297
Journal article

Risk modeling strategies for pharmacogenetic studies

Jorgensen, A. L., & Pirmohamed, M. (2011). Risk modeling strategies for pharmacogenetic studies. PHARMACOGENOMICS, 12(3), 397-410. doi:10.2217/PGS.10.198

DOI
10.2217/PGS.10.198
Journal article

Adipogenic gene variants in patients with HIV-associated lipodystrophy

Pushpakom, S. P., Owen, A., Vilar, F. J., Castro, H., Dunn, D. T., Back, D. J., & Pirmohamed, M. (2011). Adipogenic gene variants in patients with HIV-associated lipodystrophy. PHARMACOGENETICS AND GENOMICS, 21(2), 76-83. doi:10.1097/FPC.0b013e328342a917

DOI
10.1097/FPC.0b013e328342a917
Journal article

An Investigation of Disagreement in Causality Assessment of Adverse Drug Reactions

Davies, E. C., Rowe, P. H., James, S., Nickless, G., Ganguli, A., Danjuma, M., . . . Pirmohamed, M. (2011). An Investigation of Disagreement in Causality Assessment of Adverse Drug Reactions. Pharmaceutical Medicine, 25(1), 17-24. doi:10.1007/bf03256843

DOI
10.1007/bf03256843
Journal article

Brief interventions in dependent drinkers: A comparative prospective analysis in two hospitals

Cobain, K., Owens, L., Fitzgerald, R., Gilmore, I., & Pirmohamed, M. (2011). Brief interventions in dependent drinkers: A comparative prospective analysis in two hospitals. Alcohol & Alcoholism, 46(6), 434-440.

Journal article

Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology

Eschenhagen, T., Force, T., Ewer, M. S., de Keulenaer, G. W., Suter, T. M., Anker, S. D., . . . Shah, A. M. (2011). Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology. EUROPEAN JOURNAL OF HEART FAILURE, 13(1), 1-10. doi:10.1093/eurjhf/hfq213

DOI
10.1093/eurjhf/hfq213
Journal article

Changing Trends in Peptic Ulcer Disease: The Rise of NSAID-Induced and Fall of <i>Helicobacter pylori</i>-Induced Ulcers

Musumba, C. O., Van Eker, D., Jorgensen, A., Pritchard, M., & Pirmoltamed, M. (2011). Changing Trends in Peptic Ulcer Disease: The Rise of NSAID-Induced and Fall of <i>Helicobacter pylori</i>-Induced Ulcers. In GASTROENTEROLOGY Vol. 140 (pp. S176). Retrieved from https://www.webofscience.com/

Conference Paper

Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury

El-Ghaiesh, S., Sanderson, J. P., Farrell, J., Lavergne, S. N., Syn, W. -K., Pirmohamed, M., . . . Naisbitt, D. J. (2011). Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 128(3), 680-U368. doi:10.1016/j.jaci.2011.04.031

DOI
10.1016/j.jaci.2011.04.031
Journal article

Cytochrome P450 testing for prescribing antipsychotics in adults with schizophrenia: systematic review and meta-analyses

Fleeman, N., Dundar, Y., Dickson, R., Jorgensen, A., Pushpakom, S., McLeod, C., . . . Walley, T. (2011). Cytochrome P450 testing for prescribing antipsychotics in adults with schizophrenia: systematic review and meta-analyses. PHARMACOGENOMICS JOURNAL, 11(1), 1-14. doi:10.1038/tpj.2010.73

DOI
10.1038/tpj.2010.73
Journal article

INFLUENCE OF A FUNCTIONAL <i>SCN1A</i> POLYMORPHISM ON MAXIMUM AND MAINTENANCE DOSES OF ANTIEPILEPTIC DRUGS IN NEWLY DIAGNOSED EPILEPSY

Shazadi, K., Sills, G. J., Pirmohamed, M., & Marson, A. G. (2011). INFLUENCE OF A FUNCTIONAL <i>SCN1A</i> POLYMORPHISM ON MAXIMUM AND MAINTENANCE DOSES OF ANTIEPILEPTIC DRUGS IN NEWLY DIAGNOSED EPILEPSY. In EPILEPSIA Vol. 52 (pp. 91-92). Retrieved from https://www.webofscience.com/

Conference Paper

Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis

Whitaker, P., Meng, X., Lavergne, S. N., El-Ghaiesh, S., Monshi, M., Earnshaw, C., . . . Park, B. K. (2011). Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis. J Immunol, 187(1), 200-211. doi:10.4049/jimmunol.1100647

DOI
10.4049/jimmunol.1100647
Journal article

Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors

Mirza, N. S., Alfirevic, A., Jorgensen, A., Marson, A. G., & Pirmohamed, M. (2011). Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors. PHARMACOGENETICS AND GENOMICS, 21(5), 297-302. doi:10.1097/FPC.0b013e3283441b95

DOI
10.1097/FPC.0b013e3283441b95
Journal article

Pharmacogenetics of adverse drug reactions

Pushpakom, S., & Pirmohamed, M. (2011). Pharmacogenetics of adverse drug reactions. In J. Talbott, & P. Waller (Eds.), Stephens' Detection of New Adverse Drug Reactions (pp. Not known). Malden, MA, USA: John Wiley & Sons.

Chapter

Prescribing in liver disease

Pirmohamed, M. (2011). Prescribing in liver disease. Medicine, 39(9), 541-544. doi:10.1016/j.mpmed.2011.06.009

DOI
10.1016/j.mpmed.2011.06.009
Journal article

STAtin-Induced Muscle Toxicity: Exploration Using the UK GEneral Practice Research Database - Recruitment

Campbell, J., van Staa, T. P., McCann, G., O'Meara, H., & Pirmohamed, M. (2011). STAtin-Induced Muscle Toxicity: Exploration Using the UK GEneral Practice Research Database - Recruitment. In PHARMACOEPIDEMIOLOGY AND DRUG SAFETY Vol. 20 (pp. S183). Retrieved from https://www.webofscience.com/

Conference Paper

Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles

Lucena, M. I., Molokhia, M., Shen, Y., Urban, T. J., Aithal, G. P., Andrade, R. J., . . . Daly, A. K. (2011). Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles. GASTROENTEROLOGY, 141(1), 338-347. doi:10.1053/j.gastro.2011.04.001

DOI
10.1053/j.gastro.2011.04.001
Journal article

VALIDATION OF THE AUSTRALIAN FIVE-SNP GENETIC CLASSIFIER OF EARLY TREATMENT OUTCOMES IN NEWLY DIAGNOSED EPILEPSY

Sills, G., Shazadi, K., Petrovski, S., O'Brien, T., Pirmohamed, M., & Marson, A. (2011). VALIDATION OF THE AUSTRALIAN FIVE-SNP GENETIC CLASSIFIER OF EARLY TREATMENT OUTCOMES IN NEWLY DIAGNOSED EPILEPSY. In EPILEPSIA Vol. 52 (pp. 92). Retrieved from https://www.webofscience.com/

Conference Paper

2010

Acceptance of Biomarker-Based Tests for Application in Clinical Practice: Criteria and Obstacles

Pirmohamed, M. (2010). Acceptance of Biomarker-Based Tests for Application in Clinical Practice: Criteria and Obstacles. CLINICAL PHARMACOLOGY & THERAPEUTICS, 88(6), 862-866. doi:10.1038/clpt.2010.245

DOI
10.1038/clpt.2010.245
Journal article

Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury

Donaldson, P. T., Daly, A. K., Henderson, J., Graham, J., Pirmohamed, M., Bernal, W., . . . Aithal, G. P. (2010). Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury. JOURNAL OF HEPATOLOGY, 53(6), 1049-1053. doi:10.1016/j.jhep.2010.05.033

DOI
10.1016/j.jhep.2010.05.033
Journal article

Population pharmacokinetic and pharmacogenetic analysis of nevirapine in hypersensitive and tolerant HIV-infected patients from Malawi

Dickinson, L., Chaponda, M., Carr, D., van Oosterhout, J. J., Kumwenda, J., Lalloo, D. G., . . . Khoo, S. H. (2010). Population pharmacokinetic and pharmacogenetic analysis of nevirapine in hypersensitive and tolerant HIV-infected patients from Malawi. In Abstracts of the Tenth International Congress on Drug Therapy in HIV Infection Vol. 13 (pp. 181). Glasgow, UK: Journal of the International AIDS Society. doi:10.1186/1758-2652-13-S4-P181

DOI
10.1186/1758-2652-13-S4-P181
Conference Paper

Emergency re-admissions to hospital due to adverse drug reactions within 1 year of the index admission

Davies, E. C., Green, C. F., Mottram, D. R., Rowe, P. H., & Pirmohamed, M. (2010). Emergency re-admissions to hospital due to adverse drug reactions within 1 year of the index admission. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 70(5), 749-755. doi:10.1111/j.1365-2125.2010.03751.x

DOI
10.1111/j.1365-2125.2010.03751.x
Journal article

P13.04 Exploring the clinical utility of faecal biomarkers to investigate Clostridium difficile infection (CDI)

Swale, A., Miyajima, F., Farragher, T., Roberts, P., Little, M., Beeching, N. J., . . . Pirmohamed, M. (2010). P13.04 Exploring the clinical utility of faecal biomarkers to investigate Clostridium difficile infection (CDI). Journal of Hospital Infection, 76, S42. doi:10.1016/s0195-6701(10)60141-7

DOI
10.1016/s0195-6701(10)60141-7
Journal article

Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort

Carr, D. F., la Porte, C. J. L., Pirmohamed, M., Owen, A., & Cortes, C. P. (2010). Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 65(9), 1889-1893. doi:10.1093/jac/dkq260

DOI
10.1093/jac/dkq260
Journal article

A systematic review of cost effectiveness analyses of pharmacogenetic-guided dosing in treatment with coumarin derivatives

Verhoef, T. I., Redekop, W. K., Darba, J., Geitona, M., Hughes, D. A., Siebert, U., . . . Zee, A. -H. M. -V. D. (2010). A systematic review of cost effectiveness analyses of pharmacogenetic-guided dosing in treatment with coumarin derivatives. PHARMACOGENOMICS, 11(7), 989-1002. doi:10.2217/PGS.10.74

DOI
10.2217/PGS.10.74
Journal article

Interpreting adverse drug reaction (ADR) reports as hospital patient safety incidents

Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2010). Interpreting adverse drug reaction (ADR) reports as hospital patient safety incidents. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 70(1), 102-108. doi:10.1111/j.1365-2125.2010.03671.x

DOI
10.1111/j.1365-2125.2010.03671.x
Journal article

Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries (vol 38, pg 122, 2010)

Srivastava, A., Lian, L. -Y., Maggs, J. L., Chaponda, M., Pirmohamed, M., Williams, D. P., & Park, B. K. (2010). Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries (vol 38, pg 122, 2010). DRUG METABOLISM AND DISPOSITION, 38(7), 1259. doi:10.1124/dmd.38.7.1259

DOI
10.1124/dmd.38.7.1259
Journal article

Simultaneous determination of nilotinib, imatinib and its main metabolite (CGP-74588) in human plasma by ultra-violet high performance liquid chromatography

Davies, A., Hayes, A. K., Knight, K., Watmough, S. J., Pirmohamed, M., & Clark, R. E. (2010). Simultaneous determination of nilotinib, imatinib and its main metabolite (CGP-74588) in human plasma by ultra-violet high performance liquid chromatography. LEUKEMIA RESEARCH, 34(6), 702-707. doi:10.1016/j.leukres.2009.11.009

DOI
10.1016/j.leukres.2009.11.009
Journal article

Warfarin pharmacogenetics: a single <i>VKORC1</i> polymorphism is predictive of dose across 3 racial groups

Limdi, N. A., Wadelius, M., Cavallari, L., Eriksson, N., Crawford, D. C., Lee, M. -T. M., . . . Wagner, M. J. (2010). Warfarin pharmacogenetics: a single <i>VKORC1</i> polymorphism is predictive of dose across 3 racial groups. BLOOD, 115(18), 3827-3834. doi:10.1182/blood-2009-12-255992

DOI
10.1182/blood-2009-12-255992
Journal article

A Role for the Pregnane X Receptor in Flucloxacillin-Induced Liver Injury

Andrews, E., Armstrong, M., Tugwood, J., Swan, D., Glaves, P., Pirmohamed, M., . . . Daly, A. K. (2010). A Role for the Pregnane X Receptor in Flucloxacillin-Induced Liver Injury. HEPATOLOGY, 51(5), 1656-1664. doi:10.1002/hep.23549

DOI
10.1002/hep.23549
Journal article

Integration of Genetic, Clinical, and INR Data to Refine Warfarin Dosing

Lenzini, P., Wadelius, M., Kimmel, S., Anderson, J. L., Jorgensen, A. L., Pirmohamed, M., . . . Gage, B. F. (2010). Integration of Genetic, Clinical, and INR Data to Refine Warfarin Dosing. CLINICAL PHARMACOLOGY & THERAPEUTICS, 87(5), 572-578. doi:10.1038/clpt.2010.13

DOI
10.1038/clpt.2010.13
Journal article

Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future

Alfirevic, A., & Pirmohamed, M. (2010). Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future. PHARMACOGENOMICS, 11(4), 497-499. doi:10.2217/PGS.10.12

DOI
10.2217/PGS.10.12
Journal article

Pharmacogenomics: the importance of accurate phenotypes

Gurwitz, D., & Pirmohamed, M. (2010). Pharmacogenomics: the importance of accurate phenotypes. PHARMACOGENOMICS, 11(4), 469-470. doi:10.2217/PGS.10.41

DOI
10.2217/PGS.10.41
Journal article

Deletion of exon 3 in the growth hormone receptor gene in adults with growth hormone deficiency: comparison of symptomatic and asymptomatic patients

Adetunji, O. R., Blair, J. C., Javadpour, M., Alfirevic, A., Pirmohamed, M., & MacFarlane, I. A. (2010). Deletion of exon 3 in the growth hormone receptor gene in adults with growth hormone deficiency: comparison of symptomatic and asymptomatic patients. CLINICAL ENDOCRINOLOGY, 72(3), 422-423. doi:10.1111/j.1365-2265.2009.03638.x

DOI
10.1111/j.1365-2265.2009.03638.x
Journal article

Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells

Antoine, D. J., Srivastava, A., Pirmohamed, M., & Park, B. K. (2010). Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells. BIOCHEMICAL PHARMACOLOGY, 79(4), 647-654. doi:10.1016/j.bcp.2009.09.021

DOI
10.1016/j.bcp.2009.09.021
Journal article

Drug-drug interactions and adverse drug reactions: separating the wheat from the chaff

Pirmohamed, M. (2010). Drug-drug interactions and adverse drug reactions: separating the wheat from the chaff. WIENER KLINISCHE WOCHENSCHRIFT, 122(3-4), 62-64. doi:10.1007/s00508-010-1309-1

DOI
10.1007/s00508-010-1309-1
Journal article

Pharmacogenetics of idiosyncratic adverse drug reactions.

Pirmohamed, M. (2010). Pharmacogenetics of idiosyncratic adverse drug reactions.. Handbook of experimental pharmacology, (196), 477-491. doi:10.1007/978-3-642-00663-0_17

DOI
10.1007/978-3-642-00663-0_17
Journal article

Randomized Controlled Trial: Lisinopril Reduces Proteinuria, Ammonia, and Renal Polypeptide Tubular Catabolism in Patients With Chronic Allograft Nephropathy

Amara, A. B., Sharma, A., Alexander, J. L., Alfirevic, A., Mohiuddin, A., Pirmohamed, M., . . . Rustom, R. (2010). Randomized Controlled Trial: Lisinopril Reduces Proteinuria, Ammonia, and Renal Polypeptide Tubular Catabolism in Patients With Chronic Allograft Nephropathy. TRANSPLANTATION, 89(1), 104-114. doi:10.1097/TP.0b013e3181bf13d9

DOI
10.1097/TP.0b013e3181bf13d9
Journal article

Pharmacogenetics in reproductive and perinatal medicine

Alfirevic, A., Alfirevic, Z., & Pirmohamed, M. (2010). Pharmacogenetics in reproductive and perinatal medicine. PHARMACOGENOMICS, 11(1), 65-79. doi:10.2217/PGS.09.153

DOI
10.2217/PGS.09.153
Journal article

<i>VKORC1</i> and warfarin resistance

Zhang, J. E., Alfirevic, A., Carr, D., Spencer, K., Mountford, R., & Pirmohamed, M. (2010). <i>VKORC1</i> and warfarin resistance. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 70 (pp. 297). Retrieved from https://www.webofscience.com/

Conference Paper

Altered plasma levels of nevirapine after commencing rifampicin-containing TB regimens in Malawi

Chaponda, M., Nyirenda, W., Watson, V., White, S., Van Oosterhout, J., Lalloo, D., . . . Khoo, S. (2010). Altered plasma levels of nevirapine after commencing rifampicin-containing TB regimens in Malawi. In HIV MEDICINE Vol. 11 (pp. 6). Retrieved from https://www.webofscience.com/

Conference Paper

CORRELATION OF HOCT1 M420DEL SNP WITH THE CLINICAL OUTCOME OF CHRONIC MYELOID LEUKAEMIA PATIENTS TREATED WITH IMATINIB

Giannoudis, A., Wang, L., Xynarianos, G., Liloglou, T., Austin, G., Clark, J., . . . Clark, R. (2010). CORRELATION OF HOCT1 M420DEL SNP WITH THE CLINICAL OUTCOME OF CHRONIC MYELOID LEUKAEMIA PATIENTS TREATED WITH IMATINIB. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 95, 341. Retrieved from https://www.webofscience.com/

Journal article

CYP4F2 genotype-phenotype correlation in human liver

Zhang, J. E., Jorgensen, A., Kline, K., Alfirevic, A., Zanger, U., & Pirmohamed, M. (2010). CYP4F2 genotype-phenotype correlation in human liver. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 70 (pp. 297-298). Retrieved from https://www.webofscience.com/

Conference Paper

Carbamazepine-induced hypersensitivity in Caucasians and genetic variability in the major histocompatibility complex

Alfirevic, A., Bourgeois, S., Jorgensen, A., Steen, K., Weetman, D., Park, B. K., . . . Pirmohamed, M. (2010). Carbamazepine-induced hypersensitivity in Caucasians and genetic variability in the major histocompatibility complex. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 70 (pp. 298). Retrieved from https://www.webofscience.com/

Conference Paper

Characterization of <i>p</i>-Phenylenediamine-Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein

Jenkinson, C., Jenkins, R. E., Aleksic, M., Pirmohamed, M., Naisbitt, D. J., & Park, B. K. (2010). Characterization of <i>p</i>-Phenylenediamine-Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130(3), 732-742. doi:10.1038/jid.2009.271

DOI
10.1038/jid.2009.271
Journal article

Characterization of piperacillin-specific T-cell clones from hypersensitive patients with cystic fibrosis

El-Ghaiesh, S., Monshi, M., Jenkins, R., Meng, X., French, N., Whitaker, P., . . . Naisbitt, D. (2010). Characterization of piperacillin-specific T-cell clones from hypersensitive patients with cystic fibrosis. In IMMUNOLOGY Vol. 131 (pp. 117). Retrieved from https://www.webofscience.com/

Conference Paper

Drug allergy in lung disease

Ganguli, A., & Pirmohamed, M. (2010). Drug allergy in lung disease. In Drug-Induced and Iatrogenic Respiratory Disease (pp. 52-61).

Chapter

Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future.

Alfirevic, A., & Pirmohamed, M. (2010). Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future.. Pharmacogenomics, 11(4), 497-499.

Journal article

Establishment of a HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions

Bell, C., Martinsson, K., Faulkner, L., Alfirevic, A., French, N., Tugwood, J., . . . Park, B. K. (2010). Establishment of a HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions. In IMMUNOLOGY Vol. 131 (pp. 125). Retrieved from https://www.webofscience.com/

Conference Paper

GENETIC VARIABILITY IN DRUG METABOLISING ENZYMES AS DETERMINANT OF CARBAMAZEPINE DOSE REQUIREMENT IN NEWLY DIAGNOSED EPILEPSY

Shazadi, K., Sills, G. J., Alfirevic, A., Pirmohamed, M., & Marson, A. G. (2010). GENETIC VARIABILITY IN DRUG METABOLISING ENZYMES AS DETERMINANT OF CARBAMAZEPINE DOSE REQUIREMENT IN NEWLY DIAGNOSED EPILEPSY. In EPILEPSIA Vol. 51 (pp. 32). Retrieved from https://www.webofscience.com/

Conference Paper

Genetic Risk Factors for ADRs

Pirmohamed, M. (2010). Genetic Risk Factors for ADRs. In DRUG METABOLISM REVIEWS Vol. 42 (pp. 2-3). Retrieved from https://www.webofscience.com/

Conference Paper

HOCT1 M420 DELETED TRANSCRIPT LEVELS PREDICT POOR CLINICAL OUTCOME FOR IMATINIB TREATED CML PATIENTS

Wang, L., Giannoudis, A., Austin, G., Liloglou, T., Xinarianos, G., Clark, J., . . . Clark, R. (2010). HOCT1 M420 DELETED TRANSCRIPT LEVELS PREDICT POOR CLINICAL OUTCOME FOR IMATINIB TREATED CML PATIENTS. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 95, 61. Retrieved from https://www.webofscience.com/

Journal article

Involvement of drug-specific CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T-cells in trimethoprim-mediated hepatitis

El-Ghaiesh, S., Lavergne, S., Farrell, J., Syn, W., Pirmohamed, M., Park, K., & Naisbitt, D. (2010). Involvement of drug-specific CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T-cells in trimethoprim-mediated hepatitis. In IMMUNOLOGY Vol. 131 (pp. 120). Retrieved from https://www.webofscience.com/

Conference Paper

Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in <i>p</i>-Phenylenediamine Allergic Patients and Tolerant Individuals

Coulter, E. M., Jenkinson, C., Farrell, J., Lavergne, S. N., Pease, C., White, A., . . . Naisbitt, D. J. (2010). Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in <i>p</i>-Phenylenediamine Allergic Patients and Tolerant Individuals. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130(1), 161-174. doi:10.1038/jid.2009.187

DOI
10.1038/jid.2009.187
Journal article

Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals

Coulter, E. M., Jenkinson, C., Farrell, J., Lavergne, S. N., Pease, C., White, A., . . . Naisbitt, D. J. (2010). Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals. Journal of Investigative Dermatology, 130(1), 161-174. doi:10.1038/jid.2009.187

DOI
10.1038/jid.2009.187
Journal article

Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.

Mirza, N. S., Alfirevic, A., Jorgensen, A., Marson, A. G., & Pirmohamed, M. (2010). Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.. Pharmacogenetics and Genomics, 21(5), 297-302.

Journal article

Pharmaceuticals - Special Issue on Personalised Medicine

Sills, G., & Pirmohamed, M. (Eds.) (2010). Pharmaceuticals - Special Issue on Personalised Medicine. Basel: MDPI. Retrieved from http://www.mdpi.com/journal/pharmaceuticals/sections/

Book

Pharmacogenetics in reproductive and perinatal medicine

Alfirevic, A., Alfirevic, Z., & Pirmohamed, M. (2010). Pharmacogenetics in reproductive and perinatal medicine. Pharmacogenomics, 11(1), 65-79.

Journal article

Proposal of a pharmacogenetic-based dosing algorithm for the induction of warfarin anticoagulation therapy in patients with thromboembolic disease

Avery, P., Pirmohamed, M., Jorgensen, A., & Kamali, F. (2010). Proposal of a pharmacogenetic-based dosing algorithm for the induction of warfarin anticoagulation therapy in patients with thromboembolic disease. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 70 (pp. 291). Retrieved from https://www.webofscience.com/

Conference Paper

Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries

Srivastava, A., Lian, L. -Y., Maggs, J. L., Chaponda, M., Pirmohamed, M., Williams, D. P., & Park, B. K. (2010). Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries. DRUG METABOLISM AND DISPOSITION, 38(1), 122-132. doi:10.1124/dmd.109.028688

DOI
10.1124/dmd.109.028688
Journal article

Recruitment Strategy for Genetic Data Collection: The UK General Practice Research Database

Setakis, E., de Vries, F., Pirmohamed, M., & van Staa, T. -P. (2010). Recruitment Strategy for Genetic Data Collection: The UK General Practice Research Database. In PHARMACOEPIDEMIOLOGY AND DRUG SAFETY Vol. 19 (pp. S37). Retrieved from https://www.webofscience.com/

Conference Paper

The accumulation and metabolism of zidovudine in 3T3-F442A pre-adipocytes

Janneh, O., Owen, A., Bray, P. G., Back, D. J., & Pirmohamed, M. (2010). The accumulation and metabolism of zidovudine in 3T3-F442A pre-adipocytes. BRITISH JOURNAL OF PHARMACOLOGY, 159(2), 484-493. doi:10.1111/j.1476-5381.2009.00552.x

DOI
10.1111/j.1476-5381.2009.00552.x
Journal article

The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation

Fleeman, N., McLeod, C., Bagust, A., Beale, S., Boland, A., Dundar, Y., . . . Dickson, R. (2010). The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation. HEALTH TECHNOLOGY ASSESSMENT, 14(3), 1-+. doi:10.3310/hta14030

DOI
10.3310/hta14030
Journal article

2009

Effects of genetic variation at the <i>CYP21</i>9/<i>CYP2C9</i> locus on pharmacokinetics of chlorcycloguanil in adult Gambians

Janha, R. E., Sisay-Joof, F., Hamid-Adiamoh, M., Worwui, A., Chapman, H. L., Opara, H., . . . Walton, R. T. (2009). Effects of genetic variation at the <i>CYP21</i>9/<i>CYP2C9</i> locus on pharmacokinetics of chlorcycloguanil in adult Gambians. PHARMACOGENOMICS, 10(9), 1423-1431. doi:10.2217/PGS.09.72

DOI
10.2217/PGS.09.72
Journal article

Genotype-guided dosing of coumarin derivatives: the European pharmacogenetics of anticoagulant therapy (EU-PACT) trial design

van Schie, R. M. F., Wadelius, M., Kamali, F., Daly, A. K., Manolopoulos, V. G., de Boer, A., . . . Maitland-van der Zee, A. -H. (2009). Genotype-guided dosing of coumarin derivatives: the European pharmacogenetics of anticoagulant therapy (EU-PACT) trial design. PHARMACOGENOMICS, 10(10), 1687-1695. doi:10.2217/PGS.09.125

DOI
10.2217/PGS.09.125
Journal article

Folate Augmentation of Treatment-Evaluation for Depression (FolATED): protocol of a randomised controlled trial (vol 7, pg 65, 2008)

Roberts, S. H., Bedson, E., Hughes, D. A., Lloyd, K. R., Menkes, D. B., Moat, S. J., . . . Russell, I. T. (2009). Folate Augmentation of Treatment-Evaluation for Depression (FolATED): protocol of a randomised controlled trial (vol 7, pg 65, 2008). BMC PSYCHIATRY, 9. doi:10.1186/1471-244X-9-14

DOI
10.1186/1471-244X-9-14
Journal article

The d3/fl-GH receptor gene polymorphism does not influence quality of life and body composition in GH-deficient adults receiving GH replacement therapy

Adetunji, O. R., MacFarlane, I. A., Javadpour, M., Alfirevic, A., Pirmohamed, M., & Blair, J. C. (2009). The d3/fl-GH receptor gene polymorphism does not influence quality of life and body composition in GH-deficient adults receiving GH replacement therapy. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 161(4), 541-546. doi:10.1530/EJE-09-0405

DOI
10.1530/EJE-09-0405
Journal article

Effect of topiramate on acid-base balance: extent, mechanism and effects

Mirza, N., Marson, A. G., & Pirmohamed, M. (2009). Effect of topiramate on acid-base balance: extent, mechanism and effects. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 68(5), 655-661. doi:10.1111/j.1365-2125.2009.03521.x

DOI
10.1111/j.1365-2125.2009.03521.x
Journal article

Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA <i>in vitro</i> and <i>in vivo</i>

Jenkins, R. E., Meng, X., Elliott, V. L., Kitteringham, N. R., Pirmohamed, M., & Park, B. K. (2009). Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA <i>in vitro</i> and <i>in vivo</i>. PROTEOMICS CLINICAL APPLICATIONS, 3(6), 720-729. doi:10.1002/prca.200800222

DOI
10.1002/prca.200800222
Journal article

Effects of <i>CYP4F2</i> genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy

Zhang, J. E., Jorgensen, A. L., Alfirevic, A., Williamson, P. R., Toh, C. H., Park, B. K., & Pirmohamed, M. (2009). Effects of <i>CYP4F2</i> genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy. PHARMACOGENETICS AND GENOMICS, 19(10), 781-789. doi:10.1097/FPC.0b013e3283311347

DOI
10.1097/FPC.0b013e3283311347
Journal article

Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study

Jorgensen, A. L., Al-Zubiedi, S., Zhang, J. E., Keniry, A., Hanson, A., Hughes, D. A., . . . Pirmohamed, M. (2009). Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study. PHARMACOGENETICS AND GENOMICS, 19(10), 800-812. doi:10.1097/FPC.0b013e3283317ab5

DOI
10.1097/FPC.0b013e3283317ab5
Journal article

Review article: cellular and molecular mechanisms of NSAID-induced peptic ulcers

Musumba, C., Pritchard, D. M., & Pirmohamed, M. (2009). Review article: cellular and molecular mechanisms of NSAID-induced peptic ulcers. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 30(6), 517-531. doi:10.1111/j.1365-2036.2009.04086.x

DOI
10.1111/j.1365-2036.2009.04086.x
Journal article

Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models.

Deng, X., Luyendyk, J. P., Ganey, P. E., & Roth, R. A. (2009). Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models.. Pharmacological reviews, 61(3), 262-282. doi:10.1124/pr.109.001727

DOI
10.1124/pr.109.001727
Journal article

Spontaneous Hemothorax Following Anticoagulation with Low-Molecular-Weight Heparin

Ganguli, A., Walker, L., FitzGerald, R. J., & Pirmohamed, M. (2009). Spontaneous Hemothorax Following Anticoagulation with Low-Molecular-Weight Heparin. ANNALS OF PHARMACOTHERAPY, 43(9), 1528-1531. doi:10.1345/aph.1L542

DOI
10.1345/aph.1L542
Journal article

Clinical management of HIV-associated lipodystrophy

Pirmohamed, M. (2009). Clinical management of HIV-associated lipodystrophy. CURRENT OPINION IN LIPIDOLOGY, 20(4), 309-314. doi:10.1097/MOL.0b013e32832d3bb1

DOI
10.1097/MOL.0b013e32832d3bb1
Journal article

Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review

Carr, D. F., Whiteley, G., Alfirevic, A., & Pirmohamed, M. (2009). Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review. PHARMACOGENOMICS JOURNAL, 9(5), 291-305. doi:10.1038/tpj.2009.29

DOI
10.1038/tpj.2009.29
Journal article

<i>HLA</i>-<i>B<SUP>☆</SUP>5701</i> genotype is a major determinant of drug-induced liver injury due to flucloxacillin

Daly, A. K., Donaldson, P. T., Bhatnagar, P., Shen, Y., Pe'er, I., Floratos, A., . . . Day, C. P. (2009). <i>HLA</i>-<i>B<SUP>☆</SUP>5701</i> genotype is a major determinant of drug-induced liver injury due to flucloxacillin. NATURE GENETICS, 41(7), 816-U71. doi:10.1038/ng.379

DOI
10.1038/ng.379
Journal article

Characterization and Quantification of Mercapturate and Glutathione Conjugates of Nevirapine

Srivastava, A., Williams, D. P., Maggs, J. L., Lian, L. -Y., Chaponda, M., Gardner, I., . . . Park, K. (2009). Characterization and Quantification of Mercapturate and Glutathione Conjugates of Nevirapine. In TOXICOLOGY Vol. 262 (pp. 6-7). doi:10.1016/j.tox.2009.04.051

DOI
10.1016/j.tox.2009.04.051
Conference Paper

Involvement of drug-specific CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T-cells in trimethoprim-mediated hepatitis

El-Ghaiesh, S., Lavergne, S., Farell, J., Syn, W., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2009). Involvement of drug-specific CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T-cells in trimethoprim-mediated hepatitis. In TOXICOLOGY Vol. 262 (pp. 12). doi:10.1016/j.tox.2009.04.010

DOI
10.1016/j.tox.2009.04.010
Conference Paper

<i>TNF</i>, <i>LTA</i>, <i>HSPA1L</i> and <i>HLA</i>-<i>DR</i> gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole

Alfirevic, A., Vilar, F. J., Alsbou, M., Jawaid, A., Thomson, W., Ollier, W. E. R., . . . Pirmohamed, M. (2009). <i>TNF</i>, <i>LTA</i>, <i>HSPA1L</i> and <i>HLA</i>-<i>DR</i> gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole. PHARMACOGENOMICS, 10(4), 531-540. doi:10.2217/PGS.09.6

DOI
10.2217/PGS.09.6
Journal article

In Vivo and In Vitro Efficacy of Amodiaquine against <i>Plasmodium falciparum</i> in an Area of Continued Use of 4-Aminoquinolines in East Africa

Sasi, P., Abdulrahaman, A., Mwai, L., Muriithi, S., Straimer, J., Schieck, E., . . . Borrmann, S. (2009). In Vivo and In Vitro Efficacy of Amodiaquine against <i>Plasmodium falciparum</i> in an Area of Continued Use of 4-Aminoquinolines in East Africa. JOURNAL OF INFECTIOUS DISEASES, 199(11), 1575-1582. doi:10.1086/598862

DOI
10.1086/598862
Journal article

IMPACT OF PHARMACOGENETICS ON THE COSTS OF MANAGING ADVERSE EVENTS WITH WARFARIN: A PROSPECTIVE ANALYSIS

Hughes, D. A., Al-Zubiedi, S., Hanson, A., Jorgensen, A., & Pirmohamed, M. (2009). IMPACT OF PHARMACOGENETICS ON THE COSTS OF MANAGING ADVERSE EVENTS WITH WARFARIN: A PROSPECTIVE ANALYSIS. VALUE IN HEALTH, 12(3), A3-A4. doi:10.1016/S1098-3015(10)73081-3

DOI
10.1016/S1098-3015(10)73081-3
Journal article

Erratum to: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial

Roberts, S. H., Bedson, E., Hughes, D. A., Lloyd, K. R., Menkes, D. B., Moat, S. J., . . . Russell, I. T. (2009). Erratum to: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial. BMC Psychiatry, 9(1). doi:10.1186/1471-244x-9-14

DOI
10.1186/1471-244x-9-14
Journal article

Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data

Klein, T. E., Altman, R. B., Eriksson, N., Gage, B. F., Kimmel, S. E., Lee, M. -T. M., . . . Shin, J. G. (2009). Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data. NEW ENGLAND JOURNAL OF MEDICINE, 360(8), 753-764. Retrieved from https://www.webofscience.com/

Journal article

Adverse Drug Reactions in Hospital In-Patients: A Prospective Analysis of 3695 Patient-Episodes

Davies, E. C., Green, C. F., Taylor, S., Williamson, P. R., Mottram, D. R., & Pirmohamed, M. (2009). Adverse Drug Reactions in Hospital In-Patients: A Prospective Analysis of 3695 Patient-Episodes. PLOS ONE, 4(2). doi:10.1371/journal.pone.0004439

DOI
10.1371/journal.pone.0004439
Journal article

Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GA<SUP>2</SUP>LEN platform. The Galenda project

Bousquet, P. -J., Demoly, P., Romano, A., Aberer, W., Bircher, A., Blanca, M., . . . Sidoroff, A. (2009). Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GA<SUP>2</SUP>LEN platform. The Galenda project. ALLERGY, 64(2), 194-203. doi:10.1111/j.1398-9995.2008.01944.x

DOI
10.1111/j.1398-9995.2008.01944.x
Journal article

A STUDY OF PLASMA LEVELS OF IMATINIB AND ITS BIOACTIVE METABOLITE CGP-74588 REVEALS NO CORRELATION WITH SUBSEQUENT CLINICAL OUTCOME IN IMATINIB-TREATED CHRONIC MYELOID LEUKAEMIA

Davies, A., Hayes, A. K., Giannoudis, A., Lucas, C. M., Knight, K., Watmough, S. J., . . . Clark, R. E. (2009). A STUDY OF PLASMA LEVELS OF IMATINIB AND ITS BIOACTIVE METABOLITE CGP-74588 REVEALS NO CORRELATION WITH SUBSEQUENT CLINICAL OUTCOME IN IMATINIB-TREATED CHRONIC MYELOID LEUKAEMIA. In HAEMATOLOGICA-THE HEMATOLOGY JOURNAL Vol. 94 (pp. 259). Retrieved from https://www.webofscience.com/

Conference Paper

ANTICIPATING ADVERSE DRUG REACTIONS

Pirmohamed, M. (2009). ANTICIPATING ADVERSE DRUG REACTIONS. In BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Vol. 105 (pp. 3). Retrieved from https://www.webofscience.com/

Conference Paper

Adipogenic gene variants in patients with HIV-associated lipodystrophy

Pushpakom, S., Owen, A., Vilar, J., Back, D., & Pirmohamed, M. (2009). Adipogenic gene variants in patients with HIV-associated lipodystrophy. In HIV MEDICINE Vol. 10 (pp. 1). Retrieved from https://www.webofscience.com/

Conference Paper

Bioactivation of nevirapine: characterization and quantification of nevirapine mercapturate in human urine

Srivastava, A., Williams, D. P., Maggs, J. L., Lian, L. Y., Gardner, I., Chaponda, M., . . . Park, B. K. (2009). Bioactivation of nevirapine: characterization and quantification of nevirapine mercapturate in human urine. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 68(2), 276-277. Retrieved from https://www.webofscience.com/

Journal article

CARBONIC ANHYDRASE INHIBITOR-INDUCED RENAL TUBULAR ACIDOSIS

Mirza, N., Marson, A. G., & Pirmohamed, M. (2009). CARBONIC ANHYDRASE INHIBITOR-INDUCED RENAL TUBULAR ACIDOSIS. In BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Vol. 105 (pp. 84). Retrieved from https://www.webofscience.com/

Conference Paper

CARBONIC ANHYDRASE INHIBITOR-INDUCED RENAL TUBULAR ACIDOSIS

Mirza, N. S., Pirmohamed, M., & Marson, A. G. (2009). CARBONIC ANHYDRASE INHIBITOR-INDUCED RENAL TUBULAR ACIDOSIS. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 80. doi:10.1136/jnnp.2009.191775i

DOI
10.1136/jnnp.2009.191775i
Conference Paper

CARBONIC ANHYDRASE INHIBITOR-INDUCED RENAL TUBULAR ACIDOSIS

Mirza, N., Marson, A., & Pirmohamed, M. (2009). CARBONIC ANHYDRASE INHIBITOR-INDUCED RENAL TUBULAR ACIDOSIS. In EPILEPSIA Vol. 50 (pp. 109). Retrieved from https://www.webofscience.com/

Conference Paper

EMERGENCY READMISSIONS TO HOSPITAL DUE TO ADVERSE DRUG REACTIONS (ADRS): A RETROSPECTIVE STUDY

Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2009). EMERGENCY READMISSIONS TO HOSPITAL DUE TO ADVERSE DRUG REACTIONS (ADRS): A RETROSPECTIVE STUDY. In BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Vol. 105 (pp. 34). Retrieved from https://www.webofscience.com/

Conference Paper

Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data (vol 360, pg 753, 2009)

Klein, T. E., Altman, R. B., Eriksson, N., Gage, B. F., Kimmel, S. E., Lee, M. T. M., . . . Shin, J. G. (2009). Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data (vol 360, pg 753, 2009). NEW ENGLAND JOURNAL OF MEDICINE, 361(16), 1613. Retrieved from https://www.webofscience.com/

Journal article

Measurement of lymphocyte proliferation and cytokine secretion from para-phenylenediamine allergic patients and tolerant individuals

Jenkinson, C., Aleksic, M., Lavergne, S. N., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2009). Measurement of lymphocyte proliferation and cytokine secretion from para-phenylenediamine allergic patients and tolerant individuals. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 280). Retrieved from https://www.webofscience.com/

Conference Paper

Nevirapine hypersensitivity in Malawi: a prospective cohort study

Chaponda, M., Khoo, S. H., Oosterhout, J. V., Kumwenda, J., Lalloo, D., & Pirmohamed, M. (2009). Nevirapine hypersensitivity in Malawi: a prospective cohort study. In HIV MEDICINE Vol. 10 (pp. 34-35). Retrieved from https://www.webofscience.com/

Conference Paper

Nilotinib concentration in cell lines and primary CD34<SUP>+</SUP> chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters

Davies, A., Jordanides, N. E., Giannoudis, A., Lucas, C. M., Hatziieremia, S., Harris, R. J., . . . Mountford, J. C. (2009). Nilotinib concentration in cell lines and primary CD34<SUP>+</SUP> chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters. LEUKEMIA, 23(11), 1999-2006. doi:10.1038/leu.2009.166

DOI
10.1038/leu.2009.166
Journal article

RELEASE OF INTRACELLULAR CALCIUM PRIMES CHRONIC MYELOID LEUKAEMIA CELLS FOR TYROSINE KINASE INHIBITOR -INDUCED APOPTOSIS

Forchap, S. L., Pirmohamed, M., & Clark, R. E. (2009). RELEASE OF INTRACELLULAR CALCIUM PRIMES CHRONIC MYELOID LEUKAEMIA CELLS FOR TYROSINE KINASE INHIBITOR -INDUCED APOPTOSIS. In HAEMATOLOGICA-THE HEMATOLOGY JOURNAL Vol. 94 (pp. 257). Retrieved from https://www.webofscience.com/

Conference Paper

The applications of pharmacogenetics to prescribing: what is currently practicable?

Pirmohamed, M. (2009). The applications of pharmacogenetics to prescribing: what is currently practicable?. CLINICAL MEDICINE, 9(5), 493-495. doi:10.7861/clinmedicine.9-5-493

DOI
10.7861/clinmedicine.9-5-493
Journal article

2008

Pharmacogenetics of adverse drug reactions: A pharmacovigilance perspective

Alfirevic, A., & Pirmohamed, M. (2008). Pharmacogenetics of adverse drug reactions: A pharmacovigilance perspective. Journal of Applied Therapeutic Research, 6(3), 3-8.

Journal article

Genetic variants of hepatic transporters and susceptibility to drug induced liver injury

Bhatnagar, P., Day, C. P., Aithal, G., Pirmohamed, M., Bernal, W., & Daly, A. K. (2008). Genetic variants of hepatic transporters and susceptibility to drug induced liver injury. In TOXICOLOGY Vol. 253 (pp. 10). doi:10.1016/j.tox.2008.07.008

DOI
10.1016/j.tox.2008.07.008
Conference Paper

Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia

Giannoudis, A., Davies, A., Lucas, C. M., Harris, R. J., Pirmohamed, M., & Clark, R. E. (2008). Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia. BLOOD, 112(8), 3348-3354. doi:10.1182/blood-2007-10-116236

DOI
10.1182/blood-2007-10-116236
Journal article

HIV-associated lipodystrophy: a review of underlying mechanisms and therapeutic options

Mallewa, J. E., Wilkins, E., Vilar, J., Mallewa, M., Doran, D., Back, D., & Pirmohamed, M. (2008). HIV-associated lipodystrophy: a review of underlying mechanisms and therapeutic options. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 62(4), 648-660. doi:10.1093/jac/dkn251

DOI
10.1093/jac/dkn251
Journal article

The use of opioids and laxatives, and incidence of constipation, in patients requiring neck-of-femur (NOF) surgery: a pilot study

Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2008). The use of opioids and laxatives, and incidence of constipation, in patients requiring neck-of-femur (NOF) surgery: a pilot study. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 33(5), 561-566. doi:10.1111/j.1365-2710.2008.00949.x

DOI
10.1111/j.1365-2710.2008.00949.x
Journal article

Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes

Jones, S. P., Waitt, C., Sutton, R., Back, D. J., & Pirmohamed, M. (2008). Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes. AIDS, 22(11), 1293-1298. doi:10.1097/qad.0b013e3283021a4f

DOI
10.1097/qad.0b013e3283021a4f
Journal article

Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes

Jones, S. P., Waitt, C., Sutton, R., Back, D. J., & Pirmohamed, M. (2008). Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes. AIDS, 22(11), 1293-1298. doi:10.1097/QAD.0b013e3283021a4f

DOI
10.1097/QAD.0b013e3283021a4f
Journal article

Drug metabolism

Pirmohamed, M. (2008). Drug metabolism. Medicine, 36(7), 355-359. doi:10.1016/j.mpmed.2008.04.002

DOI
10.1016/j.mpmed.2008.04.002
Journal article

Important questions in Allergy: 1-drug allergy/hypersensitivity

Demoly, P., Pichler, W., Pirmohamed, M., & Romano, A. (2008). Important questions in Allergy: 1-drug allergy/hypersensitivity. ALLERGY, 63(5), 616-619. doi:10.1111/j.1398-9995.2008.01693.x

DOI
10.1111/j.1398-9995.2008.01693.x
Journal article

Interpreting adverse drug reaction reports as hospital patient safety incidents

Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2008). Interpreting adverse drug reaction reports as hospital patient safety incidents. International Journal of Pharmacy Practice, 16(SUPPL. 1).

Journal article

Pharmacologic markers and predictors of responses to imatinib therapy in patients with chronic myeloid leukemia

Clark, R. E., Davies, A., Pirmohamed, M., & Giannoudis, A. (2008). Pharmacologic markers and predictors of responses to imatinib therapy in patients with chronic myeloid leukemia. LEUKEMIA & LYMPHOMA, 49(4), 639-642. doi:10.1080/10428190701858823

DOI
10.1080/10428190701858823
Journal article

Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia

Wang, L., Giannoudis, A., Lane, S., Williamson, P., Pirmohamed, M., & Clark, R. E. (2008). Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia. CLINICAL PHARMACOLOGY & THERAPEUTICS, 83(2), 258-264. doi:10.1038/sj.clpt.6100268

DOI
10.1038/sj.clpt.6100268
Journal article

<i>p</i>-Phenylenediamine-bound irreversibly to cysteine residues on human serum albumin activates T-cells from patients allergic to hair dye

Jenkinson, C., Jenkins, R. E., Pease, C. K., Kitteringham, N. R., Aleksic, M., Pirmohamed, M., . . . Naisbitt, D. J. (2008). <i>p</i>-Phenylenediamine-bound irreversibly to cysteine residues on human serum albumin activates T-cells from patients allergic to hair dye. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 984). Retrieved from https://www.webofscience.com/

Conference Paper

A prospective study to examine the use of opioids and laxatives, and the prevalence of constipation in patients requiring emergency neck of femur (NOF) surgery

Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2008). A prospective study to examine the use of opioids and laxatives, and the prevalence of constipation in patients requiring emergency neck of femur (NOF) surgery. In PHARMACY WORLD & SCIENCE Vol. 30 (pp. 460-461). Retrieved from https://www.webofscience.com/

Conference Paper

Activation of T-Cells from allergic patients and volunteers by <i>p</i>-phenylenediamine and Bandrowski's base

Coulter, E. M., Jenkinson, C., Wu, Y., Farrell, J., Foster, B., Smith, A., . . . Naisbitt, D. J. (2008). Activation of T-Cells from allergic patients and volunteers by <i>p</i>-phenylenediamine and Bandrowski's base. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 128(4), 897-905. doi:10.1038/sj.jid.5701071

DOI
10.1038/sj.jid.5701071
Journal article

Adverse drug reactions and pharmacogenomics: recent advances

Alfirevic, A., & Pirmohamed, M. (2008). Adverse drug reactions and pharmacogenomics: recent advances. PERSONALIZED MEDICINE, 5(1), 11-23. doi:10.2217/17410541.5.1.11

DOI
10.2217/17410541.5.1.11
Journal article

Adverse drug reactions in hospital inpatients: a prospective study

Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2008). Adverse drug reactions in hospital inpatients: a prospective study. In PHARMACY WORLD & SCIENCE Vol. 30 (pp. 458-459). Retrieved from https://www.webofscience.com/

Conference Paper

Comparison of the functional characteristics of allergic and tolerant patient lymphocytes stimulated with <i>p</i>-phenylenediamine and Bandrowski's base

Coulter, E. M., Pease, C. K., White, A., Lockley, D., Basketter, D., Williams, D. P., . . . Naisbitt, D. J. (2008). Comparison of the functional characteristics of allergic and tolerant patient lymphocytes stimulated with <i>p</i>-phenylenediamine and Bandrowski's base. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 982-984). Retrieved from https://www.webofscience.com/

Conference Paper

Dasatinib uptake into chronic myeloid leukaemia cells is independent of hOCT1 expression, in contrast to imatinib

Giannoudis, A., Davies, A., Lucas, C. M., Harris, R. J., Pirmohamed, M., & Clark, R. E. (2008). Dasatinib uptake into chronic myeloid leukaemia cells is independent of hOCT1 expression, in contrast to imatinib. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 141 (pp. 41). Retrieved from https://www.webofscience.com/

Conference Paper

Development of an isocratic UV-HPLC method to measure imatinib and its metabolite, CGP-74 588, in chronic myeloid leukaemia (CML) patients

Davies, A., Hayes, A., Knight, K., Watmough, S. J., & Pirmohamed, M. (2008). Development of an isocratic UV-HPLC method to measure imatinib and its metabolite, CGP-74 588, in chronic myeloid leukaemia (CML) patients. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 141 (pp. 49-50). Retrieved from https://www.webofscience.com/

Conference Paper

Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia

Wang, L., Giannoudis, A., Lane, S., Williamson, P., Pirmohamed, M., & Clark, R. E. (2008). Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia. Clinical Pharmacology and Therapeutics, 83(2), 258-264. doi:10.1038/sj.clpt.6100268

DOI
10.1038/sj.clpt.6100268
Journal article

FLUCLOXACILLIN-INDUCED LIVER INJURY: THE EXTENDED MHC 57.1 HAPLOTYPE AS A MAJOR RISK FACTOR

Donaldson, P. T., Bhatnagar, P., Graham, J., Henderson, J., Leathart, J. B., Pirmohamed, M., . . . Daly, A. K. (2008). FLUCLOXACILLIN-INDUCED LIVER INJURY: THE EXTENDED MHC 57.1 HAPLOTYPE AS A MAJOR RISK FACTOR. In HEPATOLOGY Vol. 48 (pp. 396A-397A). Retrieved from https://www.webofscience.com/

Conference Paper

MEASUREMENT OF IMATINIB AND ITS METABOLITE, CGP-74588, IN TREATED CHRONIC MYELOID LEUKAEMIA PATEINTS BY HPLC

Davies, A., Hayes, A., Knight, K., Watmough, S. J., Pirmohamed, M., & Clark, R. E. (2008). MEASUREMENT OF IMATINIB AND ITS METABOLITE, CGP-74588, IN TREATED CHRONIC MYELOID LEUKAEMIA PATEINTS BY HPLC. In HAEMATOLOGICA-THE HEMATOLOGY JOURNAL Vol. 93 (pp. 52). Retrieved from https://www.webofscience.com/

Conference Paper

Metabolic activation of nevirapine in human and rat systems

Srivastava, A., Maggs, J. L., Pirmohamed, M., Park, B. K., & Williams, D. P. (2008). Metabolic activation of nevirapine in human and rat systems. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 1001-1002). Retrieved from https://www.webofscience.com/

Conference Paper

Nilotinib concentration in Cell Lines and CML CD34+Cells Is Not Mediated by Active Uptake or Efflux by Major Drug Transporters

Mountford, J., Davies, A., Jordanides, N. E., Giannoudis, A., Lucas, C. M., Hatziieremia, S., . . . Clark, R. E. (2008). Nilotinib concentration in Cell Lines and CML CD34+Cells Is Not Mediated by Active Uptake or Efflux by Major Drug Transporters. In BLOOD Vol. 112 (pp. 1100). Retrieved from https://www.webofscience.com/

Conference Paper

Paediatric Pharmacogenomics - Challenges and Opportunities. 2008; 2(1): 13-15

Hawcutt, D. B., & Pirmohamed, M. (2008). Paediatric Pharmacogenomics - Challenges and Opportunities. 2008; 2(1): 13-15. European Paediatrics, 2(1), 13-15.

Journal article

SUSCEPTIBILITY TO DRUG INDUCED LIVER INJURY DETERMINED BY HLA CLASS II GENOTYPE

Donaldson, P. T., Bhatnagar, P., Graham, J., Henderson, J., Leathart, J. B., Pirmohamed, M., . . . Day, C. P. (2008). SUSCEPTIBILITY TO DRUG INDUCED LIVER INJURY DETERMINED BY HLA CLASS II GENOTYPE. In HEPATOLOGY Vol. 48 (pp. 464A). Retrieved from https://www.webofscience.com/

Conference Paper

THE HUMAN ORGANIC CATION TRANSPORTER I HAS MINIMAL IMPACT IN THE UPTAKE OF DASATINIB INTO CHRONIC MYELOID LEUKAEMIA PRIMARY CELLS AND CELL LINES

Giannoudis, A., Lucas, C. M., Davies, A., Harris, R. J., Pirmohamed, M., & Clark, R. E. (2008). THE HUMAN ORGANIC CATION TRANSPORTER I HAS MINIMAL IMPACT IN THE UPTAKE OF DASATINIB INTO CHRONIC MYELOID LEUKAEMIA PRIMARY CELLS AND CELL LINES. In HAEMATOLOGICA-THE HEMATOLOGY JOURNAL Vol. 93 (pp. 312). Retrieved from https://www.webofscience.com/

Conference Paper

The burden of Adverse Drug Reactions (ADRs) on hospital inpatients - a pilot study

Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2008). The burden of Adverse Drug Reactions (ADRs) on hospital inpatients - a pilot study. In PHARMACY WORLD & SCIENCE Vol. 30 (pp. 392-393). Retrieved from https://www.webofscience.com/

Conference Paper

The pharmacokinetic profile of warfarin: a systematic review

Al-Zubiedi, S., Hughes, D., & Pirmohamed, M. (2008). The pharmacokinetic profile of warfarin: a systematic review. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 1002-1003). Retrieved from https://www.webofscience.com/

Conference Paper

Unlike imatinib, nilotinib transport into chronic myeloid leukaemia cells is not dependent on hOCT1 expression

Davies, A., Giannoudis, A., Lucas, C. M., Harris, R. J., Manley, P. W., Pirmohamed, M., & Clark, R. E. (2008). Unlike imatinib, nilotinib transport into chronic myeloid leukaemia cells is not dependent on hOCT1 expression. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 141 (pp. 41-42). Retrieved from https://www.webofscience.com/

Conference Paper

2007

Investigation into the multidimensional genetic basis of drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis

Pirmohamed, M., Arbuckle, J. B., Bowman, C. E., Brunner, M., Burns, D. K., Delrieu, O., . . . Stern, R. S. (2007). Investigation into the multidimensional genetic basis of drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis. PHARMACOGENOMICS, 8(12), 1661-1691. doi:10.2217/14622416.8.12.1661

DOI
10.2217/14622416.8.12.1661
Journal article

Tacrine-induced liver damage: an analysis of 19 candidate genes

Alfirevic, A., Mills, T., Carr, D., Barratt, B. J., Jawaid, A., Sherwood, J., . . . Pirmohamed, M. (2007). Tacrine-induced liver damage: an analysis of 19 candidate genes. PHARMACOGENETICS AND GENOMICS, 17(12), 1091-1100. doi:10.1097/FPC.0b013e3282f1f12b

DOI
10.1097/FPC.0b013e3282f1f12b
Journal article

The association between polymorphisms in <i>RLIP76</i> and drug response in epilepsy

Leschziner, G. D., Jorgensen, A. L., Andrews, T., Williamson, P. R., Marson, A. G., Coffey, A. J., . . . Pirmohamed, M. (2007). The association between polymorphisms in <i>RLIP76</i> and drug response in epilepsy. PHARMACOGENOMICS, 8(12), 1715-1722. doi:10.2217/14622416.8.12.1715

DOI
10.2217/14622416.8.12.1715
Journal article

Unlike imatinib, dasatinib uptake into chronic myeloid leukaemia cells is independent of hOCT1 expression

Giannoudis, A., Davies, A., Lucas, C. M., Harris, R. J., Pirmohamed, M., & Clark, R. E. (2007). Unlike imatinib, dasatinib uptake into chronic myeloid leukaemia cells is independent of hOCT1 expression. In BLOOD Vol. 110 (pp. 1013A-1014A). doi:10.1182/blood.V110.11.3458.3458

DOI
10.1182/blood.V110.11.3458.3458
Conference Paper

Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity

Carr, D. F., Alfirevic, A., Tugwood, J. D., Barratt, B. J., Sherwood, J., Smith, J., . . . Park, B. K. (2007). Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity. PHARMACOGENETICS AND GENOMICS, 17(11), 961-972. doi:10.1097/FPC.0b013e3282f00919

DOI
10.1097/FPC.0b013e3282f00919
Journal article

Pharmacovigilance in developing countries - Requires collaboration between stakeholders to develop novel models of funding

Pirmohamed, M., Atuah, K. N., Dodoo, A. N. O., & Winstanley, P. (2007). Pharmacovigilance in developing countries - Requires collaboration between stakeholders to develop novel models of funding. BRITISH MEDICAL JOURNAL, 335(7618), 462. doi:10.1136/bmj.39323.586123.BE

DOI
10.1136/bmj.39323.586123.BE
Journal article

Current assessment of risk-benefit by regulators: Is it time to introduce decision analyses?

Hughes, D. A., Bayoumi, A. M., & Pirmohamed, M. (2007). Current assessment of risk-benefit by regulators: Is it time to introduce decision analyses?. CLINICAL PHARMACOLOGY & THERAPEUTICS, 82(2), 123-127. doi:10.1038/sj.clpt.6100240

DOI
10.1038/sj.clpt.6100240
Journal article

Current assessment of risk-benefit by regulators: is it time to introduce decision analyses?

Hughes, D. A., Bayoumi, A. M., & Pirmohamed, M. (2007). Current assessment of risk-benefit by regulators: is it time to introduce decision analyses?. Clinical pharmacology and therapeutics, 82(2), 123-127. doi:10.1038/sj.clpt.6100240

DOI
10.1038/sj.clpt.6100240
Journal article

<i>ABCB1</i> genotype and PGP expression, function and therapeutic drug response:: a critical review and recommendations for future research

Leschziner, G. D., Andrew, T., Pirmohamed, M., & Johnson, M. R. (2007). <i>ABCB1</i> genotype and PGP expression, function and therapeutic drug response:: a critical review and recommendations for future research. PHARMACOGENOMICS JOURNAL, 7(3), 154-179. doi:10.1038/sj.tpj.6500413

DOI
10.1038/sj.tpj.6500413
Journal article

Genetics of epilepsy: Epilepsy Research Foundation Workshop Report - Abstracts

Sisodiya, S. (2007). Genetics of epilepsy: Epilepsy Research Foundation Workshop Report - Abstracts. EPILEPTIC DISORDERS, 9(2), 194-236. doi:10.1684/epd.2007.0107

DOI
10.1684/epd.2007.0107
Journal article

This is the drug for you, Madam!

Pirmohamed, M. (2007). This is the drug for you, Madam!. In Epileptic Disorders Vol. 9 (pp. 233-234).

Conference Paper

HIV and Drug Hypersensitivity

Pirmohamed, M. (2007). HIV and Drug Hypersensitivity. In Drug Hypersensitivity (pp. 84-94). KARGER. doi:10.1159/000104192

DOI
10.1159/000104192
Chapter

Drug hypersensitivity reactions in patients with HIV disease.

Pirmohamed, M., Drummond, N. S., Naisbitt, D. J., & Park, B. K. (2007). Drug hypersensitivity reactions in patients with HIV disease.. Expert review of clinical immunology, 3(3), 395-410. doi:10.1586/1744666x.3.3.395

DOI
10.1586/1744666x.3.3.395
Journal article

Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling

Sanderson, J. P., Naisbitt, D. J., Farrell, J., Ashby, C. A., Tucker, M. J., Rieder, M. J., . . . Park, B. K. (2007). Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. JOURNAL OF IMMUNOLOGY, 178(9), 5533-5542. doi:10.4049/jimmunol.178.9.5533

DOI
10.4049/jimmunol.178.9.5533
Journal article

Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling

Sanderson, J. P., Naisbitt, D. J., Farrell, J., Ashby, C. A., Tucker, M. J., Rieder, M. J., . . . Park, B. K. (2007). Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. Journal of Immunology, 178(9), 5533-5542.

Journal article

An association study of common SNPs in SREBP-2 and SCAP genes with simvastatin response in Saudi patients

Alzahrani, S., Al-Najai, M., Al-Mohanna, F., Meyer, B., Al-Shaheed, M., Mohammed, G., . . . Dzimiri, N. (2007). An association study of common SNPs in SREBP-2 and SCAP genes with simvastatin response in Saudi patients. In FASEB JOURNAL Vol. 21 (pp. A182-A183). Retrieved from https://www.webofscience.com/

Conference Paper

Generation and characterization of antigen-specific CD4<SUP>+</SUP>, CD8<SUP>+</SUP>, and CD4<SUP>+</SUP>CD8<SUP>+</SUP> T-cell clones from patients with carbamazopine hypersensitivity

Wu, Y., Farrell, J., Pirmohmed, M., Park, B. K., & Naisbitt, D. J. (2007). Generation and characterization of antigen-specific CD4<SUP>+</SUP>, CD8<SUP>+</SUP>, and CD4<SUP>+</SUP>CD8<SUP>+</SUP> T-cell clones from patients with carbamazopine hypersensitivity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 119(4), 973-981. doi:10.1016/j.jaci.2006.12.617

DOI
10.1016/j.jaci.2006.12.617
Journal article

Pharmacogenetics of warfarin: current status and future challenges

Wadelius, M., & Pirmohamed, M. (2007). Pharmacogenetics of warfarin: current status and future challenges. PHARMACOGENOMICS JOURNAL, 7(2), 99-111. doi:10.1038/sj.tpj.6500417

DOI
10.1038/sj.tpj.6500417
Journal article

Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach

Leschziner, G. D., Andrew, T., Leach, J. P., Chadwick, D., Coffey, A. J., Balding, D. J., . . . Johnson, M. R. (2007). Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach. PHARMACOGENETICS AND GENOMICS, 17(3), 217-220. doi:10.1097/01.fpc.0000230408.23146.b1

DOI
10.1097/01.fpc.0000230408.23146.b1
Journal article

Immunological principles of T-cell-mediated adverse drug reactions in skin

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2007). Immunological principles of T-cell-mediated adverse drug reactions in skin. Expert Opinion on Drug Safety, 6(2), 109-124. doi:10.1517/14740338.6.2.109

DOI
10.1517/14740338.6.2.109
Journal article

Immunological principles of T-cell-mediated adverse drug reactions in skin

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2007). Immunological principles of T-cell-mediated adverse drug reactions in skin. EXPERT OPINION ON DRUG SAFETY, 6(2), 109-124. doi:10.1517/14740338.6.2.109

DOI
10.1517/14740338.6.2.109
Journal article

Herbal medicines and acute medical emergency admissions to hospital

Constable, S., Ham, A., & Pirmohamed, M. (2007). Herbal medicines and acute medical emergency admissions to hospital. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 63(2), 247-248. doi:10.1111/j.1365-2125.2006.02817.x

DOI
10.1111/j.1365-2125.2006.02817.x
Journal article

Which drugs cause preventable admissions to hospital? A systematic review

Howard, R. L., Avery, A. J., Slavenburg, S., Royal, S., Pipe, G., Lucassen, P., & Pirmohamed, M. (2007). Which drugs cause preventable admissions to hospital? A systematic review. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 63(2), 136-147. doi:10.1111/j.1365-2125.2006.02698.x

DOI
10.1111/j.1365-2125.2006.02698.x
Journal article

Adverse drug reactions in hospitals: a narrative review.

Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2007). Adverse drug reactions in hospitals: a narrative review.. Current drug safety, 2(1), 79-87. doi:10.2174/157488607779315507

DOI
10.2174/157488607779315507
Journal article

Anticonvulsant agents

Pirmohamed, M., & Leeder, S. J. (2007). Anticonvulsant agents. In Drug-Induced Liver Disease, Second Edition (pp. 485-505).

Chapter

Characterisation of nilotinib transport in chronic myeloid leukaemia cells

Davies, A., Giannoudis, A., Lucas, C. M., Harris, R. J., Manley, P. W., Pirmohamed, M., & Clark, R. E. (2007). Characterisation of nilotinib transport in chronic myeloid leukaemia cells. In BLOOD Vol. 110 (pp. 698A). Retrieved from https://www.webofscience.com/

Conference Paper

Common ABCB1 polymorphisms are not associated with multidrug resistance in

Leschziner, G. D., Andrew, T., Leach, J. P., Chadwick, D., Coffey, A. J., Balding, D. J., . . . Johnson, M. R. (2007). Common ABCB1 polymorphisms are not associated with multidrug resistance in. Pharmacogenet Genomics. 2007 217-20., 3(3), 217-220.

Journal article

Metformin decreases serum B<sub>12</sub> concentrations in a dose-dependent fashion.: Is there a case for routine monitoring?

Constable, S., Lane, S., Vora, J., Edwards, G., Williamson, P., & Pirmohamed, M. (2007). Metformin decreases serum B<sub>12</sub> concentrations in a dose-dependent fashion.: Is there a case for routine monitoring?. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 63 (pp. 791). Retrieved from https://www.webofscience.com/

Conference Paper

Pharmacogenetics: current status, future challenges

Pirmohamed, M. (2007). Pharmacogenetics: current status, future challenges. In ACTA PAEDIATRICA Vol. 96 (pp. 166-167). Retrieved from https://www.webofscience.com/

Conference Paper

Platelet function and peri-procedural myocardial necrosis in elective Percutaneous Coronary Intervention (ePCI)

Wiper, A., Schmitt, M., Brack, M., Eccleshall, S., Goode, G., More, R., . . . Roberts, D. H. (2007). Platelet function and peri-procedural myocardial necrosis in elective Percutaneous Coronary Intervention (ePCI). In EUROPEAN HEART JOURNAL Vol. 28 (pp. 268). Retrieved from https://www.webofscience.com/

Conference Paper

Platelet inhibition and myocardial necrosis in elective coronary artery stenting

Wiper, A., Anantharanan, R., Schmitt, M., Brack, M., Chauhan, A., Eccleshall, S., . . . Roberts, D. H. (2007). Platelet inhibition and myocardial necrosis in elective coronary artery stenting. In AMERICAN JOURNAL OF CARDIOLOGY Vol. 100 (pp. 181L). Retrieved from https://www.webofscience.com/

Conference Paper

Prediction of metabolic clearance: CYP2C9 genotyping in epileptic subjects receiving phenytoin

Horman, A. J., Sathasivam, S., Pirmohamed, M., Marson, A., Chadwick, D. W., & Watson, I. D. (2007). Prediction of metabolic clearance: CYP2C9 genotyping in epileptic subjects receiving phenytoin. In THERAPEUTIC DRUG MONITORING Vol. 29 (pp. 546). Retrieved from https://www.webofscience.com/

Conference Paper

Prescribing in liver disease

Pirmohamed, M. (2007). Prescribing in liver disease. Medicine, 35(1), 31-34. doi:10.1053/j.mpmed.2006.10.009

DOI
10.1053/j.mpmed.2006.10.009
Journal article

Warfarin Pharmacogenetics

Hughes, D. A., & Pirmohamed, M. (2007). Warfarin Pharmacogenetics. PharmacoEconomics, 25(11), 899-902. doi:10.2165/00019053-200725110-00001

DOI
10.2165/00019053-200725110-00001
Journal article

Warfarin pharmacogenetics: Economic considerations

Hughes, D. A., & Pirmohamed, M. (2007). Warfarin pharmacogenetics: Economic considerations. PHARMACOECONOMICS, 25(11), 899-902. doi:10.2165/00019053-200725110-00001

DOI
10.2165/00019053-200725110-00001
Journal article

2006

Clinical and functional evidence that drug transporter expression dictates the response to imatinib in chronic myeloid leukaemia.

Wang, L., Giannoudis, A., Lane, S., Williamson, P. R., Pirmohamed, M., & Clark, R. E. (2006). Clinical and functional evidence that drug transporter expression dictates the response to imatinib in chronic myeloid leukaemia.. In BLOOD Vol. 108 (pp. 608A-609A). doi:10.1182/blood.V108.11.2145.2145

DOI
10.1182/blood.V108.11.2145.2145
Conference Paper

Warfarin: almost 60 years old and still causing problems

Pirmohamed, M. (2006). Warfarin: almost 60 years old and still causing problems. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 62(5), 509-511. doi:10.1111/j.1365-2125.2006.02806.x

DOI
10.1111/j.1365-2125.2006.02806.x
Journal article

Pharmacogenetics of HIV therapy

Owen, A., Pirmohamed, M., Khoo, S. H., & Back, D. J. (2006). Pharmacogenetics of HIV therapy. PHARMACOGENETICS AND GENOMICS, 16(10), 693-703. doi:10.1097/01.fpc.0000236338.41799.57

DOI
10.1097/01.fpc.0000236338.41799.57
Journal article

<i>HLA-B</i> locus in Caucasian patients with carbamazepine hypersensitivity

Alfirevic, A., Jorgensen, A. L., Williamson, P. R., Chadwick, D. W., Park, B. K., & Pirmohamed, M. (2006). <i>HLA-B</i> locus in Caucasian patients with carbamazepine hypersensitivity. PHARMACOGENOMICS, 7(6), 813-818. doi:10.2217/14622416.7.6.813

DOI
10.2217/14622416.7.6.813
Journal article

Pharmacogenetics in clinical practice: considerations for testing

Constable, S., Johnson, M. R., & Pirmohamed, M. (2006). Pharmacogenetics in clinical practice: considerations for testing. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 6(2), 193-205. doi:10.1586/14737159.6.2.193

DOI
10.1586/14737159.6.2.193
Journal article

Adverse drug reactions in hospital in-patients: a pilot study

Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2006). Adverse drug reactions in hospital in-patients: a pilot study. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 31(4), 335-341. doi:10.1111/j.1365-2710.2006.00744.x

DOI
10.1111/j.1365-2710.2006.00744.x
Journal article

Clinical factors and <i>ABCB1</i> polymorphisms in prediction of antiepileptic drug response:: a prospective cohort study

Leschziner, G., Jorgensen, A. L., Andrew, T., Pirmohaomed, M., Williamson, P. R., Marson, A. G., . . . Johnson, M. R. (2006). Clinical factors and <i>ABCB1</i> polymorphisms in prediction of antiepileptic drug response:: a prospective cohort study. LANCET NEUROLOGY, 5(8), 668-676. doi:10.1016/S1474-4422(06)70500-2

DOI
10.1016/S1474-4422(06)70500-2
Journal article

Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elements

Owen, A., Goldring, C., Morgan, P., Park, B. K., & Pirmohamed, M. (2006). Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elements. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 62(2), 237-242. doi:10.1111/j.1365-2125.2006.02587.x

DOI
10.1111/j.1365-2125.2006.02587.x
Journal article

Systemic illness with skin eruption, fever and positive lymphocyte transformation test in a patient on irbesartan

Constable, S., Farrell, J., Naisbitt, D., King, C., Leonard, N., & Pirmohamed, M. (2006). Systemic illness with skin eruption, fever and positive lymphocyte transformation test in a patient on irbesartan. BRITISH JOURNAL OF DERMATOLOGY, 155(2), 491-493. doi:10.1111/j.1365-2133.2006.07338.x

DOI
10.1111/j.1365-2133.2006.07338.x
Journal article

Activation of T cells by carbamazepine and carbamazepine metabolites

Wu, Y., Sanderson, J. P., Farrell, J., Drummond, N. S., Hanson, A., Bowkett, E., . . . Naisbitt, D. J. (2006). Activation of T cells by carbamazepine and carbamazepine metabolites. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 118(1), 233-241. doi:10.1016/j.jaci.2006.03.005

DOI
10.1016/j.jaci.2006.03.005
Journal article

Drug-specific T cells in an HIV-positive patient with nevirapine-induced hepatitis

Drummond, N. S., Vilar, F. J., Naisbitt, D. J., Hanson, A., Woods, A., Park, B. K., & Pirmohamed, M. (2006). Drug-specific T cells in an HIV-positive patient with nevirapine-induced hepatitis. ANTIVIRAL THERAPY, 11(3), 393-395. Retrieved from https://www.webofscience.com/

Journal article

Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance

Leschziner, G., Zabaneh, D., Pirmohamed, M., Owen, A., Rogers, J., Coffey, A. J., . . . Johnson, M. R. (2006). Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance. PHARMACOGENETICS AND GENOMICS, 16(6), 439-450. doi:10.1097/01.fpc.0000197467.21964.67

DOI
10.1097/01.fpc.0000197467.21964.67
Journal article

The future prospects of pharmacogenetics in oral anticoagulation therapy

Kamali, F., & Pirmohamed, M. (2006). The future prospects of pharmacogenetics in oral anticoagulation therapy. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 61(6), 746-751. doi:10.1111/j.1365-2125.2006.02679.x

DOI
10.1111/j.1365-2125.2006.02679.x
Journal article

Antibiotic allergy

Eschenauer, G. A., Regal, R. E., & DePestel, D. D. (2006). Antibiotic allergy. NEW ENGLAND JOURNAL OF MEDICINE, 354(21), 2293-2294. Retrieved from https://www.webofscience.com/

Journal article

Stimulant medications and attention deficit-hyperactivity disorder.

Cohen, A. L., Jhung, M. A., & Budnitz, D. S. (2006). Stimulant medications and attention deficit-hyperactivity disorder.. The New England journal of medicine, 354(21), 2294-2295. doi:10.1056/nejmc060860

DOI
10.1056/nejmc060860
Journal article

Pharmacogenetics of Adverse Drug Reactions

Alfirevic, A., & Park, B. (2006). Pharmacogenetics of Adverse Drug Reactions. In Pharmacogenetics (pp. 65-89). CRC Press. doi:10.3109/9781420016697-6

DOI
10.3109/9781420016697-6
Chapter

Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster

Alfirevic, A., Mills, T., Harrington, P., Pinel, T., Sherwood, J., Jawaid, A., . . . Pirmohamed, M. (2006). Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. PHARMACOGENETICS AND GENOMICS, 16(4), 287-296. doi:10.1097/01.fpc.0000189800.88596.7a

DOI
10.1097/01.fpc.0000189800.88596.7a
Journal article

Personalized medicine: decades away?

Lunshof, J. E., Pirmohamed, M., & Gurwitz, D. (2006). Personalized medicine: decades away?. PHARMACOGENOMICS, 7(2), 237-241. doi:10.2217/14622416.7.2.237

DOI
10.2217/14622416.7.2.237
Journal article

Antibiotic allergy

Gruchalla, R. S., & Pirmohamed, M. (2006). Antibiotic allergy. NEW ENGLAND JOURNAL OF MEDICINE, 354(6), 601-609. doi:10.1056/NEJMcp043986

DOI
10.1056/NEJMcp043986
Journal article

Genetic factors in the predisposition to drug-induced hypersensitivity reactions

Pirmohamed, M. (2006). Genetic factors in the predisposition to drug-induced hypersensitivity reactions. AAPS JOURNAL, 8(1), E20-E26. doi:10.1208/aapsj080103

DOI
10.1208/aapsj080103
Journal article

Mechanisms of Adverse Drug Reactions

Pirmohamed, M., & Park, B. K. (2006). Mechanisms of Adverse Drug Reactions. In Unknown Book (pp. 85-103). Wiley. doi:10.1002/9780470059210.ch8

DOI
10.1002/9780470059210.ch8
Chapter

<i>CTLA-4</i> and <i>ICOS</i> genes and carbamazepine-induced hypersensitivity

Zhang, J. E., Alfirevic, A., Malhotra, R., Park, B. K., & Pirmohamed, M. (2006). <i>CTLA-4</i> and <i>ICOS</i> genes and carbamazepine-induced hypersensitivity. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 87-88). Retrieved from https://www.webofscience.com/

Conference Paper

ABCB1 polymorphisms and haplotype previously associated with drug resistant epilepsy have no effect on therapeutic or adverse drug response in a large prospective epilepsy cohort

Leschziner, G., Jorgensen, A., Andrew, T., Middleditch, C., Pirmohamed, M., Williamson, P., . . . Johnson, M. R. (2006). ABCB1 polymorphisms and haplotype previously associated with drug resistant epilepsy have no effect on therapeutic or adverse drug response in a large prospective epilepsy cohort. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 77 (pp. 1394). Retrieved from https://www.webofscience.com/

Conference Paper

ACB1 polymorphisms and haplotype previously associated with drug-resistant epilepsy have no effect on therapeutic or adverse drug response in a large prospective cohort

Leschziner, G. D., Jorgensen, A., Andrew, T., Middleditch, C., Pirmohamed, M., Marson, T., . . . Johnson, M. R. (2006). ACB1 polymorphisms and haplotype previously associated with drug-resistant epilepsy have no effect on therapeutic or adverse drug response in a large prospective cohort. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 84). Retrieved from https://www.webofscience.com/

Conference Paper

Adverse drug reactions (ADRS) in hospital in-patients: A prospective analysis of 3772 patients

Davies, E. C., Green, C. F., Mottram, D. M., & Pirmohamed, M. (2006). Adverse drug reactions (ADRS) in hospital in-patients: A prospective analysis of 3772 patients. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 179). Retrieved from https://www.webofscience.com/

Conference Paper

Antecedent exercise improves glucose utilization in healthy volunteers treated with a single dose of protease inhibitor

Doran, D. A., Jones, S. P., Evans, L., Campbell, I. T., Stokes, D. J., Yates, A. P., . . . MacLaren, D. P. M. (2006). Antecedent exercise improves glucose utilization in healthy volunteers treated with a single dose of protease inhibitor. In ANTIVIRAL THERAPY Vol. 11 (pp. L36). Retrieved from https://www.webofscience.com/

Conference Paper

Antibiotic allergy - Reply

Gruchalla, R. S., & Pirmohamed, M. (2006). Antibiotic allergy - Reply. NEW ENGLAND JOURNAL OF MEDICINE, 354(21), 2294. Retrieved from https://www.webofscience.com/

Journal article

Beyond registration - measuring the public-health potential of new treatments for malaria in Africa

Lang, T., Hughes, D., Kanyok, T., Kengeya-Kayondo, J., Marsh, V., Haaland, A., . . . Winstanley, P. (2006). Beyond registration - measuring the public-health potential of new treatments for malaria in Africa. LANCET INFECTIOUS DISEASES, 6(1), 46-52. doi:10.1016/S1473-3099(05)70326-1

DOI
10.1016/S1473-3099(05)70326-1
Journal article

CD36 in HIV-related lipodystrophy syndrome: Analysis of CD36 gene polymorphisms in lipodystrophy patients and CD36 receptor expression on peripheral blood mononuclear cells

Foster, J. A., Dunn, D., Back, D. J., & Pirmohamed, M. (2006). CD36 in HIV-related lipodystrophy syndrome: Analysis of CD36 gene polymorphisms in lipodystrophy patients and CD36 receptor expression on peripheral blood mononuclear cells. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 86-87). Retrieved from https://www.webofscience.com/

Conference Paper

Characterization of cytotoxic CD8+T-cells from carbamazepine hypersensitive patients

Wu, Y., Farrell, J., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2006). Characterization of cytotoxic CD8+T-cells from carbamazepine hypersensitive patients. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 61 (pp. 632). Retrieved from https://www.webofscience.com/

Conference Paper

Chemical and molecular investigation of hazard associated with drug bioactivation

Drummond, N. S., Gardner, I., Jones, R., Wood, T., Naisbitt, D. J., Owen, A., . . . Park, B. K. (2006). Chemical and molecular investigation of hazard associated with drug bioactivation. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 180-181). Retrieved from https://www.webofscience.com/

Conference Paper

Dendritic cell metabolism of sulfamethoxazole leads to increased CD40 expression: a key determinant of immunogenicity

Sanderson, J. P., Naisbitt, D. J., Farrell, J., Drummond, N., Mathews, K. L., Pirmohamed, M., . . . Park, B. K. (2006). Dendritic cell metabolism of sulfamethoxazole leads to increased CD40 expression: a key determinant of immunogenicity. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 61 (pp. 645). Retrieved from https://www.webofscience.com/

Conference Paper

Drug Hypersnesitivity Meeting, Liverpool, 2006

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2006). Drug Hypersnesitivity Meeting, Liverpool, 2006. In 2nd International Drug Hypersnesitivity Meeting Vol. 38 (pp. 59). University Press: University Press.

Conference Paper

Effect of carbamazepine on the expression of the HSP-70 genes in B cells from hypersensitive patients

Alsbou, M., Rice, A., Alfirevic, A., Park, K., & Pirmohamed, M. (2006). Effect of carbamazepine on the expression of the HSP-70 genes in B cells from hypersensitive patients. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 170-171). Retrieved from https://www.webofscience.com/

Conference Paper

Exon resequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance

Leschziner, G. D., Zabaneh, D., Pirmohamed, M., Owen, A., Rogers, J., Coffey, A. J., . . . Johnson, M. R. (2006). Exon resequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance. Pharmacogenetics and Genomics, 16(6), 439-450.

Journal article

Genetic analysis of tacrine-induced transaminitis

Alfirevic, A., Mills, T., Carr, D., Barratt, B. J., Pinel, T., Sherwood, J., . . . Pirmohamed, M. (2006). Genetic analysis of tacrine-induced transaminitis. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 61 (pp. 644). Retrieved from https://www.webofscience.com/

Conference Paper

Haplotype structure in abc transporter genes and association of genetic variation in ABCB1, ABCC1, ABCC2, ABCC5, and ABCB4 with epilepsy outcome

Leschziner, G. D., Pirmohamed, M., Williamson, P., Marson, A., Middleditch, C., Coffey, A. J., . . . Johnson, M. R. (2006). Haplotype structure in abc transporter genes and association of genetic variation in ABCB1, ABCC1, ABCC2, ABCC5, and ABCB4 with epilepsy outcome. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 77 (pp. 127). Retrieved from https://www.webofscience.com/

Conference Paper

Identification of IL-6 as a candidate gene in tacrine-induced hepatotoxicity: Association with elevated serum transaminases

Carr, D. F., Alfirevic, A., Sherwood, J., Tugwood, J. D., Park, B. K., & Pirmohamed, M. (2006). Identification of IL-6 as a candidate gene in tacrine-induced hepatotoxicity: Association with elevated serum transaminases. DRUG METABOLISM REVIEWS, 38, 54. Retrieved from https://www.webofscience.com/

Journal article

Imatinib and human organic cation transporter 1 (hOCT1): Characterisation of transport in a stably transfected myeloid cell line, and relationship of hOCT1 expression to cytogenetic response

Wang, L., Giannoudis, A., Pirmohamed, M., & Clark, R. E. (2006). Imatinib and human organic cation transporter 1 (hOCT1): Characterisation of transport in a stably transfected myeloid cell line, and relationship of hOCT1 expression to cytogenetic response. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 118). Retrieved from https://www.webofscience.com/

Conference Paper

Individual basis of susceptibility to ADRs

Pirmohamed, M. (2006). Individual basis of susceptibility to ADRs. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 36). Retrieved from https://www.webofscience.com/

Conference Paper

Metabolism of sulphamethoxazole by dendritic cells: Implications for hypersensitivity

Sanderson, J. P., Naisbitt, D. J., Farrell, J., Drummond, N., Mathews, K. L., Pirmohamed, M., . . . Park, B. K. (2006). Metabolism of sulphamethoxazole by dendritic cells: Implications for hypersensitivity. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 182-183). Retrieved from https://www.webofscience.com/

Conference Paper

Multidrug resistance 3 (MDR3) protein and tacrine-induced hepatotoxicity

Alfirevic, A., Carr, D. F., Mills, T., Hartkoorn, R., Owen, A., Tugwood, J. D., . . . Pirmohamed, M. (2006). Multidrug resistance 3 (MDR3) protein and tacrine-induced hepatotoxicity. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 173). Retrieved from https://www.webofscience.com/

Conference Paper

Personalised medicine: decades away?

Gurwitz, D., Pirmohamed, M., & Lunshof, J. E. (2006). Personalised medicine: decades away?. In JOURNAL OF PHARMACY AND PHARMACOLOGY Vol. 58 (pp. A91). Retrieved from https://www.webofscience.com/

Conference Paper

Pharmacogenetics and Metabolic Disease

Constable, S. A., & Pirmohamed, M. (2006). Pharmacogenetics and Metabolic Disease. In I. P. Hall, & M. Pirmohamed (Eds.), Pharmacogenetics (pp. 245-274). New York: Taylor and Francis.

Chapter

Pharmacogenetics of Adverse Drug Reactions

Alfirevic, A., Park, B. K., & Pirmohamed, M. (2006). Pharmacogenetics of Adverse Drug Reactions. In I. Hall, & M. Pirmohamed (Eds.), Textbook of Pharmacogenetics (pp. in press). New York: Marcel Dekker.

Chapter

Pharmacogenetics: theoretical background and practical problems

Pirmohamed, M. (2006). Pharmacogenetics: theoretical background and practical problems. In ACTA PHARMACOLOGICA SINICA Vol. 27 (pp. 46). Retrieved from https://www.webofscience.com/

Conference Paper

Pharmacogenomics and herbal medicines

Pirmohamed, M. (2006). Pharmacogenomics and herbal medicines. In DRUG SAFETY Vol. 29 (pp. 356). Retrieved from https://www.webofscience.com/

Conference Paper

Polymorphisms in the MHC region and co-trimoxazole hypersensitivity in HIV-positive patients

Alsbou, M., Alfirevic, A., Vilar, J., Park, K., & Pirmohamed, M. (2006). Polymorphisms in the MHC region and co-trimoxazole hypersensitivity in HIV-positive patients. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 92). Retrieved from https://www.webofscience.com/

Conference Paper

Single dose atazanavir boosted with ritonavir does not induce insulin resistance in healthy volunteers

Doran, D. A., Jones, S. P., Evans, L., Campbell, I. T., Stokes, D. J., Yates, A. P., . . . MacLaren, D. P. M. (2006). Single dose atazanavir boosted with ritonavir does not induce insulin resistance in healthy volunteers. In ANTIVIRAL THERAPY Vol. 11 (pp. L39-L40). Retrieved from https://www.webofscience.com/

Conference Paper

Statins: pharmacology, current uses and widening potential

Constable, S., & Pirmohamed, M. (2006). Statins: pharmacology, current uses and widening potential. www.behindthemedicalheadlines.com. Retrieved from http://www.behindthemedicalheadlines.com/articles/statins.shtml

Journal article

Textbook of Pharmacogenetics

Hall, I., & Pirmohamed, M. (Eds.) (2006). Textbook of Pharmacogenetics. New York: Marcel Dekker.

Book

2005

Assessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudineand zidovudine-containing regimens

Jones, S. P., Qazi, N., Morelese, J., Lebrecht, D., Sutinen, J., Yki-Járvinen, H., . . . Moyle, G. J. (2005). Assessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudineand zidovudine-containing regimens. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 40(5), 565-572. doi:10.1097/01.qai.0000187443.30838.3e

DOI
10.1097/01.qai.0000187443.30838.3e
Journal article

The quality of information on monitoring for haematological adverse drug reactions

Ferner, R. E., Coleman, J., Pirmohamed, M., Constable, S. A., & Rouse, A. (2005). The quality of information on monitoring for haematological adverse drug reactions. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 60(4), 448-451. doi:10.1111/j.1365-2125.2005.02440.x

DOI
10.1111/j.1365-2125.2005.02440.x
Journal article

The role of metabolic activation in drug-induced hepatotoxicity

Park, B. K., Kitteringham, N. R., Maggs, J. L., Pirmohamed, M., & Williams, D. P. (2005). The role of metabolic activation in drug-induced hepatotoxicity. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 45, 177-202. doi:10.1146/annurev.pharmtox.45.120403.100058

DOI
10.1146/annurev.pharmtox.45.120403.100058
Journal article

How do NHS general hospitals in England deal with patients with alcohol-related problems? A questionnaire survey

Owens, L., Gilmore, I. T., & Pirmohamed, M. (2005). How do NHS general hospitals in England deal with patients with alcohol-related problems? A questionnaire survey. ALCOHOL AND ALCOHOLISM, 40(5), 409-412. doi:10.1093/alcalc/agh184

DOI
10.1093/alcalc/agh184
Journal article

Investigation of toxic metabolites during drug development.

Park, K., Williams, D. P., Naisbitt, D. J., Kitteringham, N. R., & Pirmohamed, M. (2005). Investigation of toxic metabolites during drug development.. Toxicology and applied pharmacology, 207(2 Suppl), 425-434. doi:10.1016/j.taap.2005.02.029

DOI
10.1016/j.taap.2005.02.029
Journal article

Altered adipokine response in murine 3T3-F442A adipocytes treated with protease inhibitors and nucleoside reverse transcriptase inhibitors

Jones, S. P., Janneh, O., Back, D. J., & Pirmohamed, M. (2005). Altered adipokine response in murine 3T3-F442A adipocytes treated with protease inhibitors and nucleoside reverse transcriptase inhibitors. ANTIVIRAL THERAPY, 10(2), 207-213. Retrieved from https://www.webofscience.com/

Journal article

Carbamazepine-induced acute liver failure as part of the DRESS syndrome

Syn, W. K., Naisbitt, D. J., Holt, A. P., Pirmohamed, M., & Mutimer, D. J. (2005). Carbamazepine-induced acute liver failure as part of the DRESS syndrome. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 59(8), 988-991. doi:10.1111/j.1368-5031.2005.00550.x

DOI
10.1111/j.1368-5031.2005.00550.x
Journal article

hOCT 1 and resistance to imatinib

Crossman, L. C., Druker, B. J., & Deininger, M. W. N. (2005). hOCT 1 and resistance to imatinib. BLOOD, 106(3), 1133-1134. doi:10.1182/blood-2005-02-0694

DOI
10.1182/blood-2005-02-0694
Journal article

Characterization of the T-cell response in a patient with phenindione hypersensitivity

Naisbitt, D. J., Farrell, J., Chamberlain, P. J., Hopkins, J. E., Berry, N. G., Pirmohamed, M., & Park, B. K. (2005). Characterization of the T-cell response in a patient with phenindione hypersensitivity. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 313(3), 1058-1065. doi:10.1124/jpet.105.083758

DOI
10.1124/jpet.105.083758
Journal article

Persistent neurocognitive impairments associated with severe falciparum malaria in Kenyan children

Carter, J. A., Mung'ala-Odera, V., Neville, B. G. R., Murira, G., Mturi, N., Musumba, C., & Newton, C. R. J. C. (2005). Persistent neurocognitive impairments associated with severe falciparum malaria in Kenyan children. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 76(4), 476-481. doi:10.1136/jnnp.2004.043893

DOI
10.1136/jnnp.2004.043893
Journal article

Relationship between the C<sub>3435</sub>T and G<sub>2677</sub>T(A) polymorphisms in the <i>ABCB1</i> gene and P-glycoprotein expression in human liver

Owen, A., Goldring, C., Morgan, P., Chadwick, D., Park, B. K., & Pirmohamed, M. (2005). Relationship between the C<sub>3435</sub>T and G<sub>2677</sub>T(A) polymorphisms in the <i>ABCB1</i> gene and P-glycoprotein expression in human liver. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(3), 365-370. doi:10.1111/j.1365-2125.2005.02229.x

DOI
10.1111/j.1365-2125.2005.02229.x
Journal article

Anticipating, investigating and managing the adverse effects of drugs

Pirmohamed, M. (2005). Anticipating, investigating and managing the adverse effects of drugs. CLINICAL MEDICINE, 5(1), 23-26. doi:10.7861/clinmedicine.5-1-23

DOI
10.7861/clinmedicine.5-1-23
Journal article

Assessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudine and zidovudine containing regimens

Jones, S. P., Qazi, N., Walker, U. A., Moyle, G., Back, D. J., & Pirmohamed, M. (2005). Assessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudine and zidovudine containing regimens. TOXICOLOGY, 213(3), 265-266. Retrieved from https://www.webofscience.com/

Journal article

Assessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudine- and zidovudine-containing regimens

Jones, S. P., Qazi, N., Morelese, J., Lebrecht, D., Sutinen, J., Yki-Jarvinen, H., . . . Moyle, G. J. (2005). Assessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudine- and zidovudine-containing regimens. Journal of Acquired Immune Deficiency Syndromes, 40, 562-572.

Journal article

Association between serious carbamazepine hypersensitivity reactions and the HSP70 gene cluster

Alfirevic, A., Mills, T., Harrington, P., Pinel, T., Sherwood, J., Jawaid, A., . . . Pirmohamed, M. (2005). Association between serious carbamazepine hypersensitivity reactions and the HSP70 gene cluster. TOXICOLOGY, 213(3), 264-265. Retrieved from https://www.webofscience.com/

Journal article

Drug presentation to T cells

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2005). Drug presentation to T cells. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 115(4), 876-877. doi:10.1016/j.jaci.2005.01.011

DOI
10.1016/j.jaci.2005.01.011
Journal article

Drug-specific lymphocyte proliferation in an HIV-positive patient with nevirapine hepatitis

Drummond, N. S., Vilar, J., Naisbitt, D. J., Hanson, A., Park, B. K., & Pirmohamed, M. (2005). Drug-specific lymphocyte proliferation in an HIV-positive patient with nevirapine hepatitis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(5), 635-636. Retrieved from https://www.webofscience.com/

Journal article

Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes

Jones, S. P., Waitt, C., Back, D. J., & Pirmohamed, M. (2005). Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes. In ANTIVIRAL THERAPY Vol. 10 (pp. L21-L22). Retrieved from https://www.webofscience.com/

Conference Paper

Effect of nucleoside reverse transcriptase inhibitors and protease inhibitors on TNF-α and adiponectin mRNA expression in isolated subcutaneous and omental mature human adipocytes

Jones, S. P., Waitt, C. J., Back, D. J., & Pirmohamed, M. (2005). Effect of nucleoside reverse transcriptase inhibitors and protease inhibitors on TNF-α and adiponectin mRNA expression in isolated subcutaneous and omental mature human adipocytes. TOXICOLOGY, 213(3), 266. Retrieved from https://www.webofscience.com/

Journal article

Effect of protease inhibitors on LDL receptor and IL-6 expression in lymphocytes and monocytes

Foster, J. A., Williams, D., Dunn, D., Back, D. J., & Pirmohamed, M. (2005). Effect of protease inhibitors on LDL receptor and IL-6 expression in lymphocytes and monocytes. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(5), 629-630. Retrieved from https://www.webofscience.com/

Journal article

Expression of the imatinib drug transporters hOCT1 and MDR1 levels determines imatinb response and development of BCR-ABL kinase mutations in chronic myeloid leukaemia (CML)

Clark, R. E., Knight, K., Lucas, C. M., Pirmohamed, M., & Wang, L. (2005). Expression of the imatinib drug transporters hOCT1 and MDR1 levels determines imatinb response and development of BCR-ABL kinase mutations in chronic myeloid leukaemia (CML). EXPERIMENTAL HEMATOLOGY, 33(7), 51-52. Retrieved from https://www.webofscience.com/

Journal article

G-protein β3-subunit gene polymorphism and lymphocyte proliferation in carbamazepine hypersensitivity

Alfirevic, A., Naisbitt, D. J., Wu, Y., Farrell, J., Park, B. K., & Pirmohamed, M. (2005). G-protein β3-subunit gene polymorphism and lymphocyte proliferation in carbamazepine hypersensitivity. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(5), 645. Retrieved from https://www.webofscience.com/

Journal article

Haplotype analysis in ABC transporter genes and association of genetic variation in ABCB1, ABCC1, ABCC2, ABCC5 and ABCB4 with epilepsy outcome

Leschziner, G., Pirmohamed, M., Middleditch, C., Coffey, A., Bentley, D., & Johnson, M. R. (2005). Haplotype analysis in ABC transporter genes and association of genetic variation in ABCB1, ABCC1, ABCC2, ABCC5 and ABCB4 with epilepsy outcome. In JOURNAL OF THE NEUROLOGICAL SCIENCES Vol. 238 (pp. S131). Retrieved from https://www.webofscience.com/

Conference Paper

Imatinib and hOCT1: Implications for drug resistance and interactions - Reply

Pirmohamed, M., Wang, L. H., & Clark, R. E. (2005). Imatinib and hOCT1: Implications for drug resistance and interactions - Reply. BLOOD, 106(3), 1134. Retrieved from https://www.webofscience.com/

Journal article

Lack of association between serious carbamazepine hypersensitivity reactions and HLA-B in Caucasians

Alfirevic, A., Chadwick, D. W., Park, B. K., & Pirmohamed, M. (2005). Lack of association between serious carbamazepine hypersensitivity reactions and HLA-B in Caucasians. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(5), 641. Retrieved from https://www.webofscience.com/

Journal article

Pharmacogenetic origin of adverse drug reactions: A database study of CYP2C9 and CYP2D6-metabolised drugs

Alsbou, M., Dickinson, G. L., Tucker, G. T., Park, B. K., Rostami-Hodjegan, A., & Pirmohamed, M. (2005). Pharmacogenetic origin of adverse drug reactions: A database study of CYP2C9 and CYP2D6-metabolised drugs. DRUG METABOLISM REVIEWS, 37, 26-27. Retrieved from https://www.webofscience.com/

Journal article

Pharmacogenomics and antiviral drugs

Pirmohamed, M. (2005). Pharmacogenomics and antiviral drugs. CLINICA CHIMICA ACTA, 355, S22. Retrieved from https://www.webofscience.com/

Journal article

2004

Active transport of imatinib into and out of cells: implications for drug resistance

Thomas, J., Wang, L. H., Clark, R. E., & Pirmohamed, M. (2004). Active transport of imatinib into and out of cells: implications for drug resistance. BLOOD, 104(12), 3739-3745. doi:10.1182/blood-2003-12-4276

DOI
10.1182/blood-2003-12-4276
Journal article

Lipodystrophy in patients with HIV-1 infection:: effect of stopping protease inhibitors on TNF-α and TNF-receptor levels, and on metabolic parameters

Maher, B., Lloyd, J., Wilkins, E. G. L., Fraser, W. D., Back, D., Park, B. K., & Pirmohamed, M. (2004). Lipodystrophy in patients with HIV-1 infection:: effect of stopping protease inhibitors on TNF-α and TNF-receptor levels, and on metabolic parameters. ANTIVIRAL THERAPY, 9(6), 879-887. Retrieved from https://www.webofscience.com/

Journal article

HLA-B*5701 and abacavir hypersensitivity

Watson, M. E., Pimenta, J. M., Spreen, W. R., & Hernandez, J. E. (2004). HLA-B*5701 and abacavir hypersensitivity. PHARMACOGENETICS, 14(11), 783-784. doi:10.1097/00008571-200411000-00011

DOI
10.1097/00008571-200411000-00011
Journal article

HLA-B*5701 and abacavir hypersensitivity - Reply

Hughes, D., Park, B. K., & Pirmohamed, M. (2004). HLA-B*5701 and abacavir hypersensitivity - Reply. PHARMACOGENETICS, 14(11), 784. doi:10.1097/00008571-200411000-00012

DOI
10.1097/00008571-200411000-00012
Journal article

The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease

Brind, A. M., Hurlstone, A., Edrisinghe, D., Gilmore, I., Fisher, N., Pirmohamed, M., & Fryer, A. A. (2004). The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease. ALCOHOL AND ALCOHOLISM, 39(6), 478-483. doi:10.1093/alcalc/agh105

DOI
10.1093/alcalc/agh105
Journal article

Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance

Sharma, R. A., Euden, S. A., Platton, S. L., Cooke, D. N., Shafayat, A., Hewitt, H. R., . . . Steward, W. P. (2004). Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance. CLINICAL CANCER RESEARCH, 10(20), 6847-6854. doi:10.1158/1078-0432.CCR-04-0744

DOI
10.1158/1078-0432.CCR-04-0744
Journal article

A method for the rapid depletion of albumin and immunoglobulin from human plasma

Greenough, C., Jenkins, R. E., Kitteringham, N. R., Pirmohamed, M., Park, B. K., & Pennington, S. R. (2004). A method for the rapid depletion of albumin and immunoglobulin from human plasma. PROTEOMICS, 4(10), 3107-3111. doi:10.1002/pmic.200300815

DOI
10.1002/pmic.200300815
Journal article

Adverse drug reactions as cause of admission to hospital - Admissions to ear, nose, and throat departments were not mentioned - Reply

Pirmohamed, M., James, S., Meakin, S., & Green, C. (2004). Adverse drug reactions as cause of admission to hospital - Admissions to ear, nose, and throat departments were not mentioned - Reply. BMJ-BRITISH MEDICAL JOURNAL, 329(7463), 460. doi:10.1136/bmj.329.7463.460-a

DOI
10.1136/bmj.329.7463.460-a
Journal article

Adverse drug reactions as cause of admission to hospital - Alcohol and other non-prescribed drugs may have impact on adverse drug reactions

Williams, E. R. L., & Taylor, R. E. (2004). Adverse drug reactions as cause of admission to hospital - Alcohol and other non-prescribed drugs may have impact on adverse drug reactions. BRITISH MEDICAL JOURNAL, 329(7463), 459. doi:10.1136/bmj.329.7463.459

DOI
10.1136/bmj.329.7463.459
Journal article

Adverse drug reactions as cause of admission to hospital [2] (multiple letters)

Williams, E. R. L., Taylor, R. E., Saunders, D. J., Laws, M. B., Joseph, M., Calder, N. J., . . . Breckenridge, A. M. (2004). Adverse drug reactions as cause of admission to hospital [2] (multiple letters). British Medical Journal, 329(7463), 459-460.

Journal article

Increased prevalence of epilepsy associated with severe falciparum malaria in children

Carter, J. A., Neville, B. G. R., White, S., Ross, A. J., Otieno, G., Mturi, N., . . . Newton, T. R. J. C. (2004). Increased prevalence of epilepsy associated with severe falciparum malaria in children. EPILEPSIA, 45(8), 978-981. doi:10.1111/j.0013-9580.2004.65103.x

DOI
10.1111/j.0013-9580.2004.65103.x
Journal article

Clinical pharmacology - Special safety considerations in drug development and pharmacovigilance

Atuah, K. N., Hughes, D., & Pirmohamed, M. (2004). Clinical pharmacology - Special safety considerations in drug development and pharmacovigilance. DRUG SAFETY, 27(8), 535-554. doi:10.2165/00002018-200427080-00006

DOI
10.2165/00002018-200427080-00006
Journal article

Adverse drug reactions as cause of admission to hospital: prospective analysis of 18,820 patients

Pirmohamed, M., James, S., Meakin, S., Green, C., Scott, A. K., Walley, T. J., . . . Breckenridge, A. M. (2004). Adverse drug reactions as cause of admission to hospital: prospective analysis of 18,820 patients. BMJ-BRITISH MEDICAL JOURNAL, 329(7456), 15-19. doi:10.1136/bmj.329.7456.15

DOI
10.1136/bmj.329.7456.15
Journal article

Collecting and sharing information about harms - Appropriate strategies to communicate this information are essential

Pirmohamed, M., & Darbyshire, J. (2004). Collecting and sharing information about harms - Appropriate strategies to communicate this information are essential. BMJ-BRITISH MEDICAL JOURNAL, 329(7456), 6-7. doi:10.1136/bmj.329.7456.6

DOI
10.1136/bmj.329.7456.6
Journal article

Cost-effectiveness analysis of HLA <i>B</i>*<i>5701</i> genotyping in preventing abacavir hypersensitivity

Hughes, D. A., Vilar, F. J., Ward, C. C., Alfirevic, A., Park, B. K., & Pirmohamed, M. (2004). Cost-effectiveness analysis of HLA <i>B</i>*<i>5701</i> genotyping in preventing abacavir hypersensitivity. PHARMACOGENETICS, 14(6), 335-342. doi:10.1097/00008571-200406000-00002

DOI
10.1097/00008571-200406000-00002
Journal article

Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity.

Hughes, D. A., Vilar, F. J., Ward, C. C., Alfirevic, A., Park, B. K., & Pirmohamed, M. (2004). Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity.. Pharmacogenetics, 14(6), 335-342. doi:10.1097/00008571-200406000-00002

DOI
10.1097/00008571-200406000-00002
Journal article

Drugs and the retina.

Constable, S., & Pirmohamed, M. (2004). Drugs and the retina.. Expert opinion on drug safety, 3(3), 249-259. doi:10.1517/eods.3.3.249.31070

DOI
10.1517/eods.3.3.249.31070
Journal article

Whole-blood cultures from renal-transplant patients stimulated ex vivo show that the effects of cyclosporine on lymphocyte proliferation are related to P-glycoprotein expression

Singh, D., Alexander, J., Owen, A., Rustom, R., Bone, M., Hammad, A., . . . Pirmohamed, M. (2004). Whole-blood cultures from renal-transplant patients stimulated ex vivo show that the effects of cyclosporine on lymphocyte proliferation are related to P-glycoprotein expression. TRANSPLANTATION, 77(4), 557-561. doi:10.1097/01.TP.0000114594.21317.A5

DOI
10.1097/01.TP.0000114594.21317.A5
Journal article

A proteomic investigation into the effect of paracetamol on human plasma proteins

Greenough, C. L., Jenkins, R. E., Kitteringham, N. R., Pirmohamed, M., Pennington, S. R., & Park, B. K. (2004). A proteomic investigation into the effect of paracetamol on human plasma proteins. TOXICOLOGY, 202(1-2), 96-97. Retrieved from https://www.webofscience.com/

Journal article

Active transport of imatinib into and out of cells: implications for drug resistance

Thomas, J., Wang, L., Clark, R. E., & Pirmohamed, M. (2004). Active transport of imatinib into and out of cells: implications for drug resistance. Blood, 104(12), 3739-3745. doi:10.1182/blood-2003-12-4276

DOI
10.1182/blood-2003-12-4276
Journal article

Characterization of T-cell responses in phenindione hypersensitivity

Naisbitt, D. J., Farrell, J., Chamberlain, P. J., Park, B. K., & Pirmohamed, M. (2004). Characterization of T-cell responses in phenindione hypersensitivity. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 57 (pp. 675). Retrieved from https://www.webofscience.com/

Conference Paper

Characterization of drug-specific CD4<SUP>+</SUP> T-cells expressing the skin homing receptor CCR10 in lamotrigine hypersensitivity

Farrell, J., Gibney, C. A., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2004). Characterization of drug-specific CD4<SUP>+</SUP> T-cells expressing the skin homing receptor CCR10 in lamotrigine hypersensitivity. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 57 (pp. 690). Retrieved from https://www.webofscience.com/

Conference Paper

Diagnosis of anticonvulsant hypersensitivity syndrome using an in vitro lymphocyte proliferation assay

Farrell, J., Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2004). Diagnosis of anticonvulsant hypersensitivity syndrome using an in vitro lymphocyte proliferation assay. In TOXICOLOGY Vol. 194 (pp. 255-256). Retrieved from https://www.webofscience.com/

Conference Paper

Drug-specific proliferation of lymphocytes from patients hypersensitive to carbamazepine and oxcarbazepine: cross-reactivity and possible clinical implications

Wu, Y., Farrell, J., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2004). Drug-specific proliferation of lymphocytes from patients hypersensitive to carbamazepine and oxcarbazepine: cross-reactivity and possible clinical implications. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 57 (pp. 683). Retrieved from https://www.webofscience.com/

Conference Paper

Drugs and the retina

Constable, S., & Pirmohamed, M. (2004). Drugs and the retina. Expert Opinion on Drug Safety, 3(3), 249-259. doi:10.1517/eods.3.3.249.31070

DOI
10.1517/eods.3.3.249.31070
Journal article

Influx and efflux of imatinib are mediated by active transport via drug transporter proteins

Thomas, J., Wang, L., Clark, R. E., & Pirmohamed, M. (2004). Influx and efflux of imatinib are mediated by active transport via drug transporter proteins. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 125 (pp. 39). Retrieved from https://www.webofscience.com/

Conference Paper

Intravenous therapy

Waitt, C., Waitt, P., & Pirmohamed, M. (2004). Intravenous therapy. POSTGRADUATE MEDICAL JOURNAL, 80(939), 1-6. doi:10.1136/pmj.2003.010421

DOI
10.1136/pmj.2003.010421
Journal article

Mechanisms of insulin resistance in HIV-seronegative individuals acutely treated with ritonavir boosted indinavir and atazanavir regimens

Doran, D. A., Jones, S. P., Lagathu, C., Evans, L., Cambell, I. T., Stokes, D. J., . . . Maclaren, D. P. (2004). Mechanisms of insulin resistance in HIV-seronegative individuals acutely treated with ritonavir boosted indinavir and atazanavir regimens. In ANTIVIRAL THERAPY Vol. 9 (pp. L6). Retrieved from https://www.webofscience.com/

Conference Paper

Reply

Hughes, D., Park, B. K., & Pirmohamed, M. (2004). Reply. Pharmacogenetics, 14(11), 784. doi:10.1097/00008571-200411000-00012

DOI
10.1097/00008571-200411000-00012
Journal article

Role of the immune system in idiosyncratic drug reactions

Pirmohamed, M. (2004). Role of the immune system in idiosyncratic drug reactions. In DRUG METABOLISM REVIEWS Vol. 36 (pp. 29). Retrieved from https://www.webofscience.com/

Conference Paper

T-cell recognition of carbamazepine and carbamazepine metabolites

Naisbitt, D. J., Wu, Y., Farrell, J., O'Neill, P. M., Pirmohamed, M., & Park, B. K. (2004). T-cell recognition of carbamazepine and carbamazepine metabolites. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 57(5), 669. Retrieved from https://www.webofscience.com/

Journal article

2003

Drug point - Possible interaction between warfarin and cranberry juice

Suvarna, R., Pirmohamed, M., & Henderson, L. (2003). Drug point - Possible interaction between warfarin and cranberry juice. BRITISH MEDICAL JOURNAL, 327(7429), 1454. doi:10.1136/bmj.327.7429.1454

DOI
10.1136/bmj.327.7429.1454
Journal article

Monitoring drug treatment - Criteria used for screening tests should apply to monitoring

Pirmohamed, M., & Ferner, R. E. (2003). Monitoring drug treatment - Criteria used for screening tests should apply to monitoring. BRITISH MEDICAL JOURNAL, 327(7425), 1179-1181. doi:10.1136/bmj.327.7425.1179

DOI
10.1136/bmj.327.7425.1179
Journal article

Monitoring of long-term toxicities of HIV treatments: an international perspective

Bisson, G., Gross, R., Miller, V., Weller, I., & Walker, A. (2003). Monitoring of long-term toxicities of HIV treatments: an international perspective. AIDS, 17(17), 2407-2417. doi:10.1097/00002030-200311210-00002

DOI
10.1097/00002030-200311210-00002
Journal article

Abacavir hypersensitivity: Is pre-prescription genotyping cost-effective?

Hughes, D. A., & Pirmohamed, M. (2003). Abacavir hypersensitivity: Is pre-prescription genotyping cost-effective?. In VALUE IN HEALTH Vol. 6 (pp. 749). doi:10.1016/S1098-3015(10)61908-0

DOI
10.1016/S1098-3015(10)61908-0
Conference Paper

Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro

Williams, D. P., O'Donnell, C. J. L., Maggs, J. L., Leeder, J. S., Uetrecht, J., Pirmohamed, M., & Park, B. K. (2003). Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro. CHEMICAL RESEARCH IN TOXICOLOGY, 16(10), 1359-1364. doi:10.1021/tx034035z

DOI
10.1021/tx034035z
Journal article

Cytochrome P450 enzyme polymorphisms and adverse drug reactions

Pirmohamed, M., & Park, B. K. (2003). Cytochrome P450 enzyme polymorphisms and adverse drug reactions. TOXICOLOGY, 192(1), 23-32. doi:10.1016/S0300-483X(03)00247-6

DOI
10.1016/S0300-483X(03)00247-6
Journal article

Intracellular disposition and metabolic effects of zidovudine, stavudine and four protease inhibitors in cultured adipocytes

Janneh, O., Haggard, P., Tjia, J. F., Jones, S. P., Khoo, S. H., Maher, B., . . . Pirmohamed, M. (2003). Intracellular disposition and metabolic effects of zidovudine, stavudine and four protease inhibitors in cultured adipocytes. ANTIVIRAL THERAPY, 8(5), 417-426. Retrieved from https://www.webofscience.com/

Journal article

The BPS web site for Continuing Professional Development in Clinical Pharmacology and Therapeutics

Mucklow, J., Baber, N., Maxwell, S., & Pirmohamed, M. (2003). The BPS web site for Continuing Professional Development in Clinical Pharmacology and Therapeutics. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 56(4), 349-350. doi:10.1046/j.1365-2125.2003.01971.x

DOI
10.1046/j.1365-2125.2003.01971.x
Journal article

Herbal medicines

Pirmohamed, M. (2003). Herbal medicines. POSTGRADUATE MEDICAL JOURNAL, 79(935), 489. doi:10.1136/pmj.79.935.489

DOI
10.1136/pmj.79.935.489
Journal article

Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-Cell responses in animals and humans

Farrell, J., Naisbitt, D. J., Drummond, N. S., Depta, J. P. H., Vilar, F. J., Pirmohamed, M., & Park, B. K. (2003). Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-Cell responses in animals and humans. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 306(1), 229-237. doi:10.1124/jpet.103.050112

DOI
10.1124/jpet.103.050112
Journal article

The role of polymorphism in manganese superoxide dismutase in susceptibility to alcoholic liver disease

Brind, A., Fryer, A., Hurlstone, A., Fisher, N., & Pirmohamed, M. (2003). The role of polymorphism in manganese superoxide dismutase in susceptibility to alcoholic liver disease. GASTROENTEROLOGY, 124(7), 2000-2002. doi:10.1016/S0016-5085(03)00574-2

DOI
10.1016/S0016-5085(03)00574-2
Journal article

Characterization of drug-specific T cells in lamotrigine hypersensitivity

Naisbitt, D. J., Farrell, J., Wong, G., Depta, J. P. H., Dodd, C. C., Hopkins, J. E., . . . Park, B. K. (2003). Characterization of drug-specific T cells in lamotrigine hypersensitivity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 111(6), 1393-1403. doi:10.1067/mai.2003.1507

DOI
10.1067/mai.2003.1507
Journal article

Adverse drug reactions: back to the future

Pirmohamed, M., & Park, B. K. (2003). Adverse drug reactions: back to the future. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 55(5), 486-492. doi:10.1046/j.1365-2125.2003.01847.x

DOI
10.1046/j.1365-2125.2003.01847.x
Journal article

Reporting of adverse drug reactions by nurses

Morrison-Griffiths, S., Walley, T. J., Park, B. K., Breckenridge, A. M., & Pirmohamed, M. (2003). Reporting of adverse drug reactions by nurses. LANCET, 361(9366), 1347-1348. doi:10.1016/S0140-6736(03)13043-7

DOI
10.1016/S0140-6736(03)13043-7
Journal article

Erratum

Erratum (2003). British Journal of Clinical Pharmacology, 55(4), 417. doi:10.1046/j.1365-2125.2003.01815.x

DOI
10.1046/j.1365-2125.2003.01815.x
Journal article

Hypersensitivity reactions to carbamazepine: Characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones

Naisbitt, D. J., Britschgi, M., Wong, G., Farrell, J., Depta, J. P. H., Chadwick, D. W., . . . Park, B. K. (2003). Hypersensitivity reactions to carbamazepine: Characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones. MOLECULAR PHARMACOLOGY, 63(3), 732-741. doi:10.1124/mol.63.3.732

DOI
10.1124/mol.63.3.732
Journal article

Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity

Alfirevic, A., Stalford, A. C., Vilar, F. J., Wilkins, E. G. L., Park, B. K., & Pirmohamed, M. (2003). Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 55(2), 158-165. doi:10.1046/j.1365-2125.2003.01754.x

DOI
10.1046/j.1365-2125.2003.01754.x
Journal article

Abacavir hypersensitivity in human immunodeficiency virus-positive patients:: demonstration of the presence of drug-specific lymphocyte proliferation <i>in vitro</i>

Dodd, C. C., Naisbitt, D. J., Vilar, F. J., Gordon, S. F., Maggs, J. L., Park, B. K., & Pirmohamed, M. (2003). Abacavir hypersensitivity in human immunodeficiency virus-positive patients:: demonstration of the presence of drug-specific lymphocyte proliferation <i>in vitro</i>. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 55 (pp. 421). Retrieved from https://www.webofscience.com/

Conference Paper

Active transport of imatinib into and out of cells: Implications for drug resistance.

Thomas, J., Wang, L. H., Clark, R. E., & Pirmohamed, M. (2003). Active transport of imatinib into and out of cells: Implications for drug resistance.. In BLOOD Vol. 102 (pp. 859A). Retrieved from https://www.webofscience.com/

Conference Paper

Altered adipocytokine gene ex-pression in murine 3T3-F442A adipocytes treated with protease inhibitors and nucleoside reverse transcriptase inhibitors

Jones, S. P., Janneh, O., Back, D. J., & Pirmohamed, M. (2003). Altered adipocytokine gene ex-pression in murine 3T3-F442A adipocytes treated with protease inhibitors and nucleoside reverse transcriptase inhibitors. In ANTIVIRAL THERAPY Vol. 8 (pp. L11-L12). Retrieved from https://www.webofscience.com/

Conference Paper

Cerebral malaria - Optimising management

Mturi, N., Musumba, C. O., Wamola, B. M., Ogutu, B. R., & Newton, C. R. J. C. (2003). Cerebral malaria - Optimising management. CNS DRUGS, 17(3), 153-165. doi:10.2165/00023210-200317030-00002

DOI
10.2165/00023210-200317030-00002
Journal article

Characterisation of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and man

Farrell, J., Naisbitt, D. J., Depta, J. P. H., Pichler, W. J., Pirmohamed, M., & Park, B. K. (2003). Characterisation of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and man. TOXICOLOGY, 192(1), 83-84. Retrieved from https://www.webofscience.com/

Journal article

Characterization of lamotrigine-specific T cells from hypersensitive patients.

Naisbitt, D. J., Farrell, J., Hopkins, J. E., Wong, G., Pichler, W. J., Pirmohamed, M., & Park, K. (2003). Characterization of lamotrigine-specific T cells from hypersensitive patients.. In TOXICOLOGICAL SCIENCES Vol. 72 (pp. 52). Retrieved from https://www.webofscience.com/

Conference Paper

Drug-induced apoptosis: Clinical significance

Pirmohamed, M. (2003). Drug-induced apoptosis: Clinical significance. In DRUG METABOLISM REVIEWS Vol. 35 (pp. 24). Retrieved from https://www.webofscience.com/

Conference Paper

Hypersensitivity reactions to lamotrigine: Characterization of drug-specific T-cell clones

Naisbitt, D. J., Farrell, J., Wong, G., Dodd, C. C., Hopkins, J. E., Depta, J. P. H., . . . Park, B. K. (2003). Hypersensitivity reactions to lamotrigine: Characterization of drug-specific T-cell clones. In TOXICOLOGY Vol. 192 (pp. 82-83). Retrieved from https://www.webofscience.com/

Conference Paper

Immunopharmacology of hypersensitivity reactions to drugs

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2003). Immunopharmacology of hypersensitivity reactions to drugs. CURRENT ALLERGY AND ASTHMA REPORTS, 3(1), 22-29. doi:10.1007/s11882-003-0006-9

DOI
10.1007/s11882-003-0006-9
Journal article

Intracellular disposition and metabolic effects of zidovudine, stavudine and four protease inhibitors in cultured adipocytes

Janneh, O., Hoggard, P. G., Tjia, J. F., Jones, S. P., Khoo, S. H., Maher, B., . . . Pirmohamed, M. (2003). Intracellular disposition and metabolic effects of zidovudine, stavudine and four protease inhibitors in cultured adipocytes. Antivir Ther, 8(5), 417-426. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/14640389

Journal article

Mechanisms of drug hypersensitivity in HIV-infected patients: the role of the immune system.

Vilar, F. J., Naisbitt, D. J., Park, B. K., & Pirmohamed, M. (2003). Mechanisms of drug hypersensitivity in HIV-infected patients: the role of the immune system.. Journal of HIV therapy, 8(2), 42-47.

Journal article

Mode of uptake, accumulation and intracellular disposition of zidovudine in cultured 3T3-F442A preadiplocytes

Janneh, O., Bray, P. G., Owen, A., Back, D. J., & Pirmohamed, M. (2003). Mode of uptake, accumulation and intracellular disposition of zidovudine in cultured 3T3-F442A preadiplocytes. In ANTIVIRAL THERAPY Vol. 8 (pp. L24-L25). Retrieved from https://www.webofscience.com/

Conference Paper

NFκB in human neutrophils:: relationship between apoptosis and glutathione concentrations

Hanrahan, N. J., O'Donnell, C., Williams, D. P., Pirmohamed, M., & Park, B. K. (2003). NFκB in human neutrophils:: relationship between apoptosis and glutathione concentrations. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 55 (pp. 441). Retrieved from https://www.webofscience.com/

Conference Paper

P450 polymorphisms and adverse drug reactions

Pirmohamed, M. (2003). P450 polymorphisms and adverse drug reactions. In TOXICOLOGY Vol. 192 (pp. 55-56). Retrieved from https://www.webofscience.com/

Conference Paper

Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity (vol 55, pg 158, 2002)

Alfirevic, A., Stalford, A. C., Vilar, F. J., Wilkins, E. G. L., Park, B. K., & Pirmohamed, M. (2003). Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity (vol 55, pg 158, 2002). BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 55(4), 417. Retrieved from https://www.webofscience.com/

Journal article

The effects of cyclosporin on lymphocyte proliferation in renal transplant patients: Role of P-glycoprotein

Alexander, J. L., Singh, D., Owen, A., Rustom, R., Bone, J. M., Hammad, A., . . . Pirmohamed, M. (2003). The effects of cyclosporin on lymphocyte proliferation in renal transplant patients: Role of P-glycoprotein. In JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Vol. 14 (pp. 180A). Retrieved from https://www.webofscience.com/

Conference Paper

Transcription factor regulation and gene expression in response to the antipsychotic, clozapine

Williams, D. P., O'Donnell, C., Randle, L. E., Goldring, C. E. P., Garcia-Allen, C., Johnston, G., . . . Park, B. K. (2003). Transcription factor regulation and gene expression in response to the antipsychotic, clozapine. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 55(4), 446. Retrieved from https://www.webofscience.com/

Journal article

2002

The danger hypothesis - potential role in idiosyncratic drug reactions

Pirmohamed, M., Naisbitt, D. J., Gordon, F., & Park, B. K. (2002). The danger hypothesis - potential role in idiosyncratic drug reactions. TOXICOLOGY, 181, 55-63. doi:10.1016/S0300-483X(02)00255-X

DOI
10.1016/S0300-483X(02)00255-X
Journal article

TNF-α promoter region gene polymorphisms in HIV-positive patients with lipodystrophy

Maher, B., Alfirevic, A., Vilar, F. J., Wilkins, E. G. L., Park, B. K., & Pirmohamed, M. (2002). TNF-α promoter region gene polymorphisms in HIV-positive patients with lipodystrophy. AIDS, 16(15), 2013-2018. doi:10.1097/00002030-200210180-00005

DOI
10.1097/00002030-200210180-00005
Journal article

Anticonvulsant Agents

Leeder, J., & Pirmohamed, M. (2002). Anticonvulsant Agents. In Drug-Induced Liver Disease, Second Edition. Informa Healthcare. doi:10.1201/9780203909126.ch18

DOI
10.1201/9780203909126.ch18
Chapter

Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation

Naisbitt, D. J., Farrell, J., Gordon, S. F., Maggs, J. L., Burkhart, C., Pichler, W. J., . . . Park, B. K. (2002). Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation. MOLECULAR PHARMACOLOGY, 62(3), 628-637. doi:10.1124/mol.62.3.628

DOI
10.1124/mol.62.3.628
Journal article

Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases

Ilett, K. F., Ethell, B. T., Maggs, J. L., Davis, T. M. E., Batty, K. T., Burchell, B., . . . Edwards, G. (2002). Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases. DRUG METABOLISM AND DISPOSITION, 30(9), 1005-1012. doi:10.1124/dmd.30.9.1005

DOI
10.1124/dmd.30.9.1005
Journal article

Are chemically reactive metabolites responsible for adverse reactions to drugs?

Williams, D. P., Kitteringham, N. R., Naisbitt, D. J., Pirmohamed, M., Smith, D. A., & Park, B. K. (2002). Are chemically reactive metabolites responsible for adverse reactions to drugs?. Current drug metabolism, 3(4), 351-366. doi:10.2174/1389200023337423

DOI
10.2174/1389200023337423
Journal article

Pre-registration nurse education in pharmacology: is it adequate for the roles that nurses are expected to fulfil?

Morrison-Griffiths, S., Snowden, M. A., & Pirmohamed, M. (2002). Pre-registration nurse education in pharmacology: is it adequate for the roles that nurses are expected to fulfil?. Nurse Education Today, 22(6), 447-456. doi:10.1054/nedt.2002.0756

DOI
10.1054/nedt.2002.0756
Journal article

Best evidence and the clinical decision making process

Pirmohamed, M. (2002). Best evidence and the clinical decision making process. POSTGRADUATE MEDICAL JOURNAL, 78(919), 316. doi:10.1136/pmj.78.919.316

DOI
10.1136/pmj.78.919.316
Journal article

Absence of correlation between C<sub>3435</sub>T polymorphism in the <i>MDRI</i> gene and expression of P-glycoprotein in human liver

Owen, A., Goldring, C., Morgan, P., Park, B. K., & Pirmohamed, M. (2002). Absence of correlation between C<sub>3435</sub>T polymorphism in the <i>MDRI</i> gene and expression of P-glycoprotein in human liver. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 53 (pp. 420P). Retrieved from https://www.webofscience.com/

Conference Paper

Altered TNF-α and IL-6 levels and the antiadipogenic effects of antiretrovirals on cultured adipocytes:: possible mechanisms for their role in lipodystrophy in HIV-infected patients

Jones, S. P., Janneh, O., Maher, B., Khoo, S., Back, D. J., & Pirmohamed, M. (2002). Altered TNF-α and IL-6 levels and the antiadipogenic effects of antiretrovirals on cultured adipocytes:: possible mechanisms for their role in lipodystrophy in HIV-infected patients. In ANTIVIRAL THERAPY Vol. 7 (pp. L2). Retrieved from https://www.webofscience.com/

Conference Paper

Anticonvulsant hypersensitivity syndrome: Methodology to investigate the role of metabolism and processing of carbamazepine to T-cells

Naisbitt, D. J., Depta, J., Wong, G., Farrell, J., Chadwick, D. W., Pichler, W. J., . . . Park, B. K. (2002). Anticonvulsant hypersensitivity syndrome: Methodology to investigate the role of metabolism and processing of carbamazepine to T-cells. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 53 (pp. 443P). Retrieved from https://www.webofscience.com/

Conference Paper

Anticonvulsant hypersensitivity syndrome: characterization of the phenotype and cytokine profile of carabamazepine-specific T-cell clones

Naisbitt, D. J., Britschgi, M., Wong, G., Farrell, J., Chadwick, D. W., Pichler, W. J., . . . Park, B. K. (2002). Anticonvulsant hypersensitivity syndrome: characterization of the phenotype and cytokine profile of carabamazepine-specific T-cell clones. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 53 (pp. 418P-419P). Retrieved from https://www.webofscience.com/

Conference Paper

Are chemically reactive metabolites responsible for adverse reactions to drugs?

Williams, D. P., Kitteringham, N. R., Naisbitt, D. J., Pirmohamed, M., Smith, D. A., & Park, B. K. (2002). Are chemically reactive metabolites responsible for adverse reactions to drugs?. Curr Drug Metab, 3(4), 351-366.

Journal article

Clozapine metabolism and redox regulation of transcription factors in human neutrophils

O'Donnell, C., Williams, D. P., Pirmohamed, M., Uetrecht, J. P., & Park, B. K. (2002). Clozapine metabolism and redox regulation of transcription factors in human neutrophils. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 53 (pp. 419P-420P). Retrieved from https://www.webofscience.com/

Conference Paper

Intracellular disposition of zidovudine, stavudine and protease inhibitors and their metabolic effects in cultured adipocytes

Janneh, O., Hoggard, P. G., Sales, S. D., Jones, S. P., Tjia, J. F., Khoo, S. H., . . . Pirmohamed, M. (2002). Intracellular disposition of zidovudine, stavudine and protease inhibitors and their metabolic effects in cultured adipocytes. In ANTIVIRAL THERAPY Vol. 7 (pp. L1-L2). Retrieved from https://www.webofscience.com/

Conference Paper

MHC-restricted and processing dependent presentation of drug metabolite-modified cellular proteins to T-cells in the rat

Farrell, J., Gordon, S. F., Naisbitt, D. J., Gallimore, A., Burkhart, C., Pichler, W. J., . . . Park, B. K. (2002). MHC-restricted and processing dependent presentation of drug metabolite-modified cellular proteins to T-cells in the rat. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 53 (pp. 442P). Retrieved from https://www.webofscience.com/

Conference Paper

Pre-registration nurse education in pharmacology: is it adequate for the roles that nurses are expected to fulfil?

Morrison-Griffiths, S., Snowden, M. A., & Pirmohamed, M. (2002). Pre-registration nurse education in pharmacology: is it adequate for the roles that nurses are expected to fulfil?. NURSE EDUCATION TODAY, 22(6), 447-456. doi:10.1054/nedt.2002.0756

DOI
10.1054/nedt.2002.0756
Journal article

Prospective survey for the burden of alcohol-related admissions to an inner-city intensive care unit

Owens, L., Pirmohamed, M., & Mostafa, S. (2002). Prospective survey for the burden of alcohol-related admissions to an inner-city intensive care unit. In INTENSIVE CARE MEDICINE Vol. 28 (pp. S160). Retrieved from https://www.webofscience.com/

Conference Paper

TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy

Maher, B., Alfirevic, A., Vilar, F. J., Wilkins, E. G., Park, B. K., & Pirmohamed, M. (2002). TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy. AIDS, 16(15), 2013-2018. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12370499

Journal article

2001

Polymorphisms in the TNF-α and TNF-receptor genes in patients with coronary artery disease

Allen, R. A., Lee, E. M., Roberts, D. H., Park, B. K., & Pirmohamed, M. (2001). Polymorphisms in the TNF-α and TNF-receptor genes in patients with coronary artery disease. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 31(10), 843-851. doi:10.1046/j.1365-2362.2001.00907.x

DOI
10.1046/j.1365-2362.2001.00907.x
Journal article

Short-term exercise training improves body composition and hyperlipidaemia in HIV-positive individuals with lipodystrophy

Jones, S. P., Doran, D. A., Leat, P. B., Maher, B., & Pirmohamed, M. (2001). Short-term exercise training improves body composition and hyperlipidaemia in HIV-positive individuals with lipodystrophy. AIDS, 15(15), 2049-2051. doi:10.1097/00002030-200110190-00021

DOI
10.1097/00002030-200110190-00021
Journal article

Pharmacogenetics and pharmacogenomics

Pirmohamed, M. (2001). Pharmacogenetics and pharmacogenomics. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 52(4), 345-347. doi:10.1046/j.0306-5251.2001.01498.x

DOI
10.1046/j.0306-5251.2001.01498.x
Journal article

LC determination of carbamazepine in murine brain

Owen, A., Tettey, J. N., Morgan, P., Pirmohamed, M., & Park, B. K. (2001). LC determination of carbamazepine in murine brain. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 26(4), 573-577. doi:10.1016/S0731-7085(01)00477-0

DOI
10.1016/S0731-7085(01)00477-0
Journal article

Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo

Tettey, J. N., Maggs, J. L., Rapeport, W. G., Pirmohamed, M., & Park, B. K. (2001). Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo. CHEMICAL RESEARCH IN TOXICOLOGY, 14(8), 965-974. doi:10.1021/tx0001981

DOI
10.1021/tx0001981
Journal article

Genetic determinants of dose optimisation: molecular biology in the prevention of drug toxicity

Pirmohamed, M., & Park, B. K. (2001). Genetic determinants of dose optimisation: molecular biology in the prevention of drug toxicity. In OPTIMAL DOSE IDENTIFICATION Vol. 1220 (pp. 187-202). doi:10.1016/S0531-5131(01)00297-7

DOI
10.1016/S0531-5131(01)00297-7
Conference Paper

HIV and drug allergy

Pirmohamed, M., & Park, B. K. (2001). HIV and drug allergy. Current Opinion in Allergy and Clinical Immunology, 1(4), 311-316. doi:10.1097/01.all.0000011032.69243.10

DOI
10.1097/01.all.0000011032.69243.10
Journal article

Optimal dose identification: Predicting a safe dose in man from animal studies

Park, B. K., Kitteringham, N. R., Maggs, J. L., Boocock, D., White, I., Elsby, R., & Pirmohamed, M. (2001). Optimal dose identification: Predicting a safe dose in man from animal studies. In OPTIMAL DOSE IDENTIFICATION Vol. 1220 (pp. 13-25). doi:10.1016/S0531-5131(01)00283-7

DOI
10.1016/S0531-5131(01)00283-7
Conference Paper

Reactive metabolites and their role in drug reactions

Naisbitt, D. J., Williams, D. P., Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (2001). Reactive metabolites and their role in drug reactions. Current Opinion in Allergy and Clinical Immunology, 1(4), 317-325. doi:10.1097/01.all.0000011033.64625.5a

DOI
10.1097/01.all.0000011033.64625.5a
Journal article

Drug metabolism and drug toxicity

Park, B. K., Kitteringham, N. R., Kenny, J. R., & Pirmohamed, M. (2001). Drug metabolism and drug toxicity. InflammoPharmacology, 9(1-2), 183-199. doi:10.1163/156856001300248461

DOI
10.1163/156856001300248461
Journal article

Genetic susceptibility to adverse drug reactions

Pirmohamed, M., & Park, B. K. (2001). Genetic susceptibility to adverse drug reactions. TRENDS IN PHARMACOLOGICAL SCIENCES, 22(6), 298-305. doi:10.1016/S0165-6147(00)01717-X

DOI
10.1016/S0165-6147(00)01717-X
Journal article

Carbamazepine is not a substrate for P-glycoprotein

Owen, A., Pirmohamed, M., Tettey, J. N., Morgan, P., Chadwick, D., & Park, B. K. (2001). Carbamazepine is not a substrate for P-glycoprotein. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 51(4), 345-349. doi:10.1046/j.1365-2125.2001.01359.x

DOI
10.1046/j.1365-2125.2001.01359.x
Journal article

TNFα promoter region gene polymorphisms in carbamazepine-hypersensitive patients

Pirmohamed, M., Lin, K., Chadwick, D., & Park, B. K. (2001). TNFα promoter region gene polymorphisms in carbamazepine-hypersensitive patients. NEUROLOGY, 56(7), 890-896. doi:10.1212/WNL.56.7.890

DOI
10.1212/WNL.56.7.890
Journal article

TNFα promoter region gene polymorphisms in carbamazepine-hypersensitive patients

Pirmohamed, M., Lin, K., Chadwick, D., & Park, B. K. (2001). TNFα promoter region gene polymorphisms in carbamazepine-hypersensitive patients. Neurology, 56(7), 890-896. doi:10.1212/WNL.56.7.890

DOI
10.1212/WNL.56.7.890
Journal article

Interleukin-10 promoter region polymorphisms and alcoholic liver disease

Newberry, H., Edirisinghe, D., Fisher, N., Gilmore, I. T., Adams, D., Park, B. K., & Pirmohamed, M. (2001). Interleukin-10 promoter region polymorphisms and alcoholic liver disease. In GASTROENTEROLOGY Vol. 120 (pp. A543). Retrieved from https://www.webofscience.com/

Conference Paper

TNF-α promoter region gene polymorphisms in patients with alcohol-induced chronic pancreatitis

Ahdulrazeg, E. S. M., Alfirevic, A., Gilmore, I. T., Sutton, R., Greenhalf, W., Neoptolemas, J., . . . Pirmohamed, M. (2001). TNF-α promoter region gene polymorphisms in patients with alcohol-induced chronic pancreatitis. In GASTROENTEROLOGY Vol. 120 (pp. A32-A33). Retrieved from https://www.webofscience.com/

Conference Paper

Toxicogenetics in drug development

Park, B. K., & Pirmohamed, M. (2001). Toxicogenetics in drug development. TOXICOLOGY LETTERS, 120(1-3), 281-291. doi:10.1016/S0378-4274(01)00280-6

DOI
10.1016/S0378-4274(01)00280-6
Journal article

Attitudes and knowledge of hospital pharmacists to adverse drug reaction reporting

Green, C. F., Mottram, D. R., Rowe, P. H., & Pirmohamed, M. (2001). Attitudes and knowledge of hospital pharmacists to adverse drug reaction reporting. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 51(1), 81-86. doi:10.1046/j.1365-2125.2001.01306.x

DOI
10.1046/j.1365-2125.2001.01306.x
Journal article

Metabolic activation in drug allergies

Park, B. K., Naisbitt, D. J., Gordon, S. F., Kitteringham, N. R., & Pirmohamed, M. (2001). Metabolic activation in drug allergies. TOXICOLOGY, 158(1-2), 11-23. doi:10.1016/S0300-483X(00)00397-8

DOI
10.1016/S0300-483X(00)00397-8
Journal article

Antigenicity and immunogenicity of sulphamethoxazole:: demonstration of metabolism-dependent haptenation and T-cell proliferation <i>in vivo</i>

Naisbitt, D. J., Gordon, S. F., Pirmohamed, M., Burkhart, C., Cribb, A. E., Pichler, W. J., & Park, B. K. (2001). Antigenicity and immunogenicity of sulphamethoxazole:: demonstration of metabolism-dependent haptenation and T-cell proliferation <i>in vivo</i>. BRITISH JOURNAL OF PHARMACOLOGY, 133(2), 295-305. doi:10.1038/sj.bjp.0704074

DOI
10.1038/sj.bjp.0704074
Journal article

Clozapine undergoes organ-specific bioactivation and protein binding: Toxicological implications

O'Donnell, C., Williams, D., Pirmohamed, M., & Park, B. K. (2001). Clozapine undergoes organ-specific bioactivation and protein binding: Toxicological implications. In TOXICOLOGY Vol. 168 (pp. 132-133). Retrieved from https://www.webofscience.com/

Conference Paper

Elevated pyrimidopurinone-deoxyguanosine adducts in adenomas of Apc<SUP>Min</SUP> mice and suppression by dietary curcumin

Sharma, R. A., Perkins, S., Singh, R., Steward, W. P., & Gescher, A. (2001). Elevated pyrimidopurinone-deoxyguanosine adducts in adenomas of Apc<SUP>Min</SUP> mice and suppression by dietary curcumin. In BRITISH JOURNAL OF CANCER Vol. 85 (pp. 40). Retrieved from https://www.webofscience.com/

Conference Paper

HIV and drug allergy

Pirmohamed, M., & Park, B. K. (2001). HIV and drug allergy. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 1(4), 311-316. doi:10.1097/00130832-200108000-00006

DOI
10.1097/00130832-200108000-00006
Journal article

Pharmacodynamic and pharmacokinetic study of oral <i>Curcuma</i> extract in patients with colorectal cancer

Sharma, R. A., McLelland, H. R., Hill, K. A., Ireson, C. R., Euden, S. A., Manson, M. M., . . . Steward, W. P. (2001). Pharmacodynamic and pharmacokinetic study of oral <i>Curcuma</i> extract in patients with colorectal cancer. CLINICAL CANCER RESEARCH, 7(7), 1894-1900. Retrieved from https://www.webofscience.com/

Journal article

Pilot study of <i>Curcuma</i> extract in patients:: Safety and biological activity

Sharma, R. A., McLelland, H. R., Ireson, C. R., Jones, D. J. L., Hill, K. A., Euden, S. A., . . . Steward, W. P. (2001). Pilot study of <i>Curcuma</i> extract in patients:: Safety and biological activity. In BRITISH JOURNAL OF CANCER Vol. 85 (pp. 40). Retrieved from https://www.webofscience.com/

Conference Paper

Reactive metabolites and their role in drug reactions

Naisbitt, D. J., Williams, D. P., Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (2001). Reactive metabolites and their role in drug reactions. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 1(4), 317-325. Retrieved from https://www.webofscience.com/

Journal article

TNF-alpha promoter region gene polymorphisms in patients with alcohol-induced chronic pancreatitis

Ahdulrazeg, E. S. M., Alfirevic, A., Gilmore, I. T., Sutton, R., Greenhalf, W., Neoptolemas, J., . . . Pirmohamed, M. (2001). TNF-alpha promoter region gene polymorphisms in patients with alcohol-induced chronic pancreatitis. In Gastroenterology (Vol. 120, Iss. 5, pp. 167). [Paper].

Other

The burden of alcohol on an inner-city intensive care unit in the UK

Owens, L., Mostafa, S. M., Gilmore, I. T., Murthy, B. V., & Pirmohamed, M. (2001). The burden of alcohol on an inner-city intensive care unit in the UK. INTENSIVE CARE MEDICINE, 27, S153. Retrieved from https://www.webofscience.com/

Journal article

The danger hypothesis: inflammation and idiosyncratic toxicity

Pirmohamed, M., Naisbitt, D. J., & Park, B. K. (2001). The danger hypothesis: inflammation and idiosyncratic toxicity. In TOXICOLOGY Vol. 164 (pp. 5). Retrieved from https://www.webofscience.com/

Conference Paper

The pharmacogenomics of HIV therapy.

Pirmohamed, M., & Back, D. J. (2001). The pharmacogenomics of HIV therapy.. The pharmacogenomics journal, 1(4), 243-253. doi:10.1038/sj.tpj.6500069

DOI
10.1038/sj.tpj.6500069
Journal article

2000

Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity

Pirmohamed, M., Alfirevic, A., Vilar, J., Stalford, A., Wilkins, E. G. L., Sim, E., & Park, B. K. (2000). Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity. PHARMACOGENETICS, 10(8), 705-713. doi:10.1097/00008571-200011000-00005

DOI
10.1097/00008571-200011000-00005
Journal article

Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection

Naisbitt, D. J., Vilar, F. J., Stalford, A. C., Wilkins, E. G. L., Pirmohamed, M., & Park, B. K. (2000). Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection. AIDS RESEARCH AND HUMAN RETROVIRUSES, 16(18), 1929-1938. doi:10.1089/088922200750054657

DOI
10.1089/088922200750054657
Journal article

Adverse drug reactions as a cause of admission to an acute medical assessment unit: a pilot study

Green, C. F., Mottram, D. R., Rowe, P. H., & Pirmohamed, M. (2000). Adverse drug reactions as a cause of admission to an acute medical assessment unit: a pilot study. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 25(5), 355-361. doi:10.1046/j.1365-2710.2000.00298.x

DOI
10.1046/j.1365-2710.2000.00298.x
Journal article

Advances in molecular toxicology-towards understanding idiosyncratic drug toxicity

Park, B. K., Kitteringham, N. R., Powell, H., & Pirmohamed, M. (2000). Advances in molecular toxicology-towards understanding idiosyncratic drug toxicity. TOXICOLOGY, 153(1-3), 39-60. doi:10.1016/S0300-483X(00)00303-6

DOI
10.1016/S0300-483X(00)00303-6
Journal article

Metabolism of lamotrigine to a reactive arene oxide intermediate

Maggs, J. L., Naisbitt, D. J., Tettey, J. N. A., Pirmohamed, M., & Park, B. K. (2000). Metabolism of lamotrigine to a reactive arene oxide intermediate. CHEMICAL RESEARCH IN TOXICOLOGY, 13(11), 1075-1081. doi:10.1021/tx0000825

DOI
10.1021/tx0000825
Journal article

Commentary - bisphosphonates and calcium homoeostasis

Pirmohamed, M. (2000). Commentary - bisphosphonates and calcium homoeostasis. POSTGRADUATE MEDICAL JOURNAL, 76(897), 418-419. doi:10.1136/pmj.76.897.418

DOI
10.1136/pmj.76.897.418
Journal article

Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine

Williams, D. P., Pirmohamed, M., Naisbitt, D. J., Uetrecht, J. P., & Park, B. K. (2000). Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine. MOLECULAR PHARMACOLOGY, 58(1), 207-216. doi:10.1124/mol.58.1.207

DOI
10.1124/mol.58.1.207
Journal article

Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4<SUP>+</SUP> T cells from allergic individuals

Schnyder, B., Burkhart, C., Schnyder-Frutig, K., von Greyerz, S., Naisbitt, D. J., Pirmohamed, M., . . . Pichler, W. J. (2000). Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4<SUP>+</SUP> T cells from allergic individuals. JOURNAL OF IMMUNOLOGY, 164(12), 6647-6654. doi:10.4049/jimmunol.164.12.6647

DOI
10.4049/jimmunol.164.12.6647
Journal article

General practice nurses' knowledge of alcohol use and misuse: A questionnaire survey

Owens, L., Gilmore, I. T., & Pirmohamed, M. (2000). General practice nurses' knowledge of alcohol use and misuse: A questionnaire survey. ALCOHOL AND ALCOHOLISM, 35(3), 259-262. doi:10.1093/alcalc/35.3.259

DOI
10.1093/alcalc/35.3.259
Journal article

Alcohol abuse and the burden on the NHS - time for action

Pirmohamed, M., & Gilmore, I. T. (2000). Alcohol abuse and the burden on the NHS - time for action. JOURNAL OF THE ROYAL COLLEGE OF PHYSICIANS OF LONDON, 34(2), 161-162. Retrieved from https://www.webofscience.com/

Journal article

A simple sore throat?

Maher, B., Carey, P., & Pirmohamed, M. (2000). A simple sore throat?. HOSPITAL MEDICINE, 61(6), 435. doi:10.12968/hosp.2000.61.6.1364

DOI
10.12968/hosp.2000.61.6.1364
Journal article

Clinicians' attitudes to reporting adverse drug reactions

Tyrer, F., Breckenridge, A., Pirmohamed, M., Babiker, A., Hooker, M., Swart, A. M., . . . Darbyshire, J. (2000). Clinicians' attitudes to reporting adverse drug reactions. In AIDS Vol. 14 (pp. S65). Retrieved from https://www.webofscience.com/

Conference Paper

Decreased activity of the enzyme CYP2C9 does not protect against sulphonamide hypersensitivity in HIV positive patients

Stalford, A. C., Vilar, F. J., Alfirevic, A., Wilkins, E. G. L., Pirmohamed, M., & Park, B. K. (2000). Decreased activity of the enzyme CYP2C9 does not protect against sulphonamide hypersensitivity in HIV positive patients. In AIDS Vol. 14 (pp. S97). Retrieved from https://www.webofscience.com/

Conference Paper

Hepatocellular response to chemical stress in CD-1 mice:: Induction of early genes and γ-glutamylcysteine synthetase

Kitteringham, N. R., Powell, H., Clement, Y. N., Dodd, C. C., Tettey, J. N. A., Pirmohamed, M., . . . Park, B. K. (2000). Hepatocellular response to chemical stress in CD-1 mice:: Induction of early genes and γ-glutamylcysteine synthetase. HEPATOLOGY, 32(2), 321-333. doi:10.1053/jhep.2000.9602

DOI
10.1053/jhep.2000.9602
Journal article

Immunological principles of adverse drug reactions - The initiation and propagation of immune responses elicited by drug treatment

Naisbitt, D. J., Gordon, S. F., Pirmohamed, M., & Park, B. K. (2000). Immunological principles of adverse drug reactions - The initiation and propagation of immune responses elicited by drug treatment. DRUG SAFETY, 23(6), 483-507. doi:10.2165/00002018-200023060-00002

DOI
10.2165/00002018-200023060-00002
Journal article

Is carbamezapine a substrate for P-glycoprotein?

Owen, A., Pirmohamed, M., Tettey, J., Morgan, P., Chadwick, D., & Park, B. K. (2000). Is carbamezapine a substrate for P-glycoprotein?. In British Journal of Clinical Pharmacology Vol. 50 (pp. 387).

Conference Paper

Lipodystrophy in patients with HIV-1 infection: effect of stopping protease inhibitors on TNF-receptor levels, insulin resistance, and lipid profile

Maher, B., Lloyd, J., Wilkins, E. G. L., Fraser, W. D., Back, D. J., Park, B. K., & Pirmohamed, M. (2000). Lipodystrophy in patients with HIV-1 infection: effect of stopping protease inhibitors on TNF-receptor levels, insulin resistance, and lipid profile. In AIDS Vol. 14 (pp. S56). Retrieved from https://www.webofscience.com/

Conference Paper

Specialist nurse reporting of adverse drug reactions.

Morrison-Griffiths, S., & Pirmohamed, M. (2000). Specialist nurse reporting of adverse drug reactions.. Professional nurse (London, England), 15(5), 300-304.

Journal article

The burden of alcohol misuse on an inner-city general hospital

Pirmohamed, M., Brown, C., Owens, L., Luke, C., Gilmore, I. T., Breckenridge, A. M., & Park, B. K. (2000). The burden of alcohol misuse on an inner-city general hospital. QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS, 93(5), 291-295. doi:10.1093/qjmed/93.5.291

DOI
10.1093/qjmed/93.5.291
Journal article

1999

<i>Adverse drug reaction of the month</i> -: Haemolytic anaemia associated with indinavir

Morrison-Griffiths, S., Newman, M., O'Mahony, C., & Pirmohamed, M. (1999). <i>Adverse drug reaction of the month</i> -: Haemolytic anaemia associated with indinavir. POSTGRADUATE MEDICAL JOURNAL, 75(883), 313-315. doi:10.1136/pgmj.75.883.313

DOI
10.1136/pgmj.75.883.313
Journal article

Adverse drug reactions: role of enzyme inhibition and induction

Pirmohamed, M., & Park, B. K. (1999). Adverse drug reactions: role of enzyme inhibition and induction. In VARIABILITY IN HUMAN DRUG RESPONSE Vol. 8 (pp. 41-53). Retrieved from https://www.webofscience.com/

Conference Paper

Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity

Naisbitt, D. J., Hough, S. J., Gill, H. J., Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (1999). Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity. BRITISH JOURNAL OF PHARMACOLOGY, 126(6), 1393-1407. doi:10.1038/sj.bjp.0702453

DOI
10.1038/sj.bjp.0702453
Journal article

Communication regarding adverse drug reactions between secondary and primary care: a postal questionnaire survey of general practitioners

Green, C. F., Mottram, D. R., Pirmohamed, M., Horner, R., & Rowe, P. H. (1999). Communication regarding adverse drug reactions between secondary and primary care: a postal questionnaire survey of general practitioners. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 24(2), 133-139. doi:10.1046/j.1365-2710.1999.00210.x

DOI
10.1046/j.1365-2710.1999.00210.x
Journal article

The adverse effects of drugs

Pirmohamed, M., & Park, B. K. (1999). The adverse effects of drugs. HOSPITAL MEDICINE, 60(5), 348-352. doi:10.12968/hosp.1999.60.5.1114

DOI
10.12968/hosp.1999.60.5.1114
Journal article

The effect of genetic polymorphisms in CYP2C9 on sulphamethoxazole <i>N</i>-hydroxylation

Gill, H. J., Tjia, J. F., Kitteringham, N. R., Pirmohamed, M., Back, D. J., & Park, B. K. (1999). The effect of genetic polymorphisms in CYP2C9 on sulphamethoxazole <i>N</i>-hydroxylation. PHARMACOGENETICS, 9(1), 43-53. doi:10.1097/00008571-199902000-00007

DOI
10.1097/00008571-199902000-00007
Journal article

1998

Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs

Naisbitt, D. J., Williams, D. P., O'Neill, P. M., Maggs, J. L., Willock, D. J., Pirmohamed, M., & Park, B. K. (1998). Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs. CHEMICAL RESEARCH IN TOXICOLOGY, 11(12), 1586-1595. doi:10.1021/tx980148k

DOI
10.1021/tx980148k
Journal article

Safety assessment of peroxide antimalarials: clinical and chemical perspectives

Park, B. K., O'Neill, P. M., Maggs, J. L., & Pirmohamed, M. (1998). Safety assessment of peroxide antimalarials: clinical and chemical perspectives. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 46(6), 521-529. doi:10.1046/j.1365-2125.1998.00838.x

DOI
10.1046/j.1365-2125.1998.00838.x
Journal article

Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype and phenotype

Powell, H., Kitteringham, N. R., Pirmohamed, M., Smith, D. A., & Park, B. K. (1998). Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype and phenotype. PHARMACOGENETICS, 8(5), 411-421. doi:10.1097/00008571-199810000-00006

DOI
10.1097/00008571-199810000-00006
Journal article

Role of drug disposition in drug hypersensitivity: A chemical, molecular, and clinical perspective

Park, B. E., Pirmohamed, M., & Kitteringham, N. R. (1998). Role of drug disposition in drug hypersensitivity: A chemical, molecular, and clinical perspective. CHEMICAL RESEARCH IN TOXICOLOGY, 11(9), 969-988. doi:10.1021/tx980058f

DOI
10.1021/tx980058f
Journal article

No association between tacrine transaminitis and the glutathione transferase θ genotype in patients with Alzheimer's disease

De Sousa, M., Pirmohamed, M., Kitteringham, N. R., Woolf, T., & Park, B. K. (1998). No association between tacrine transaminitis and the glutathione transferase θ genotype in patients with Alzheimer's disease. PHARMACOGENETICS, 8(4), 353-355. Retrieved from https://www.webofscience.com/

Journal article

Fortnightly review - Adverse drug reactions

Pirmohamed, M., Breckenridge, A. M., Kitteringham, N. R., & Park, B. K. (1998). Fortnightly review - Adverse drug reactions. BRITISH MEDICAL JOURNAL, 316(7140), 1295-1298. doi:10.1136/bmj.316.7140.1295

DOI
10.1136/bmj.316.7140.1295
Journal article

Risperidone-induced photosensitivity

Almond, D. S., Rhodes, L. E., & Pirmohamed, M. (1998). Risperidone-induced photosensitivity. POSTGRADUATE MEDICAL JOURNAL, 74(870), 252-253. doi:10.1136/pgmj.74.870.252

DOI
10.1136/pgmj.74.870.252
Journal article

Reporting of adverse drug reactions: practice in the UK.

Morrison-Griffiths, S., Pirmohamed, M., & Walley, T. (1998). Reporting of adverse drug reactions: practice in the UK.. Nursing times, 94(10), 52-54.

Journal article

3 The pharmacology of the cytochrome P450 enzyme system

Kitteringham, N. R., Pirmohamed, M., & Park, B. K. (1998). 3 The pharmacology of the cytochrome P450 enzyme system. Baillière's Clinical Anaesthesiology, 12(2), 191-211. doi:10.1016/s0950-3501(98)80028-7

DOI
10.1016/s0950-3501(98)80028-7
Journal article

Polymorphisms in the interleukin I cytokine gene family are not involved in adverse reactions to carbamazepine or tacrine.

Kitteringham, N. R., Pirmohamed, M., Wakil, L., Woolf, T., & Park, B. K. (1998). Polymorphisms in the interleukin I cytokine gene family are not involved in adverse reactions to carbamazepine or tacrine.. In NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY Vol. 358 (pp. R432). Retrieved from https://www.webofscience.com/

Conference Paper

1997

Chapter 37 Idiosyncratic drug reactions

Pirmohamed, M., & Park, B. K. (1997). Chapter 37 Idiosyncratic drug reactions. Unknown Journal, 737-761. doi:10.1016/s1569-2582(97)80098-0

DOI
10.1016/s1569-2582(97)80098-0
Journal article

Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: Possible role in agranulocytosis

Williams, D. P., Pirmohamed, M., Naisbitt, D. J., Maggs, J. L., & Park, B. K. (1997). Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: Possible role in agranulocytosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 283(3), 1375-1382. Retrieved from https://www.webofscience.com/

Journal article

Polymorphism in gene for microsomal epoxide hydrolase and lung disease (multiple letters) [7]

Pirmohamed, M., Kitteringham, N. R., Park, B. K., Smith, C. A. D., Harrison, D. J., Paolini, M., & Chieco, P. (1997). Polymorphism in gene for microsomal epoxide hydrolase and lung disease (multiple letters) [7]. Lancet, 350(9090), 1553-1554. doi:10.1016/s0140-6736(05)63988-8

DOI
10.1016/s0140-6736(05)63988-8
Journal article

Polymorphism in gene for microsomal epoxide hydrolase and lung disease

Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (1997). Polymorphism in gene for microsomal epoxide hydrolase and lung disease. LANCET, 350(9090), 1553. doi:10.1016/S0140-6736(05)63988-8

DOI
10.1016/S0140-6736(05)63988-8
Journal article

Comparison of the metabolism and toxicity of dapsone in rat, mouse and man

Tingle, M. D., Mahmud, R., Maggs, J. L., Pirmohamed, M., & Park, B. K. (1997). Comparison of the metabolism and toxicity of dapsone in rat, mouse and man. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 283(2), 817-823. Retrieved from https://www.webofscience.com/

Journal article

The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat

Gill, H. J., Hough, S. J., Naisbitt, D. J., Maggs, J. L., Kitteringham, N. R., Pirmohamed, M., & Park, B. K. (1997). The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 282(2), 795-801. Retrieved from https://www.webofscience.com/

Journal article

Hepatitis B vaccine and neurotoxicity

Pirmohamed, M., & Winstanley, P. (1997). Hepatitis B vaccine and neurotoxicity. POSTGRADUATE MEDICAL JOURNAL, 73(861), 462-463. doi:10.1136/pgmj.73.861.462

DOI
10.1136/pgmj.73.861.462
Journal article

Disposition of amodiaquine and related antimalarial agents in human neutrophils: Implications for drug design

Naisbitt, D. J., Ruscoe, J. E., Williams, D., ONeill, P. M., Pirmohamed, M., & Park, B. K. (1997). Disposition of amodiaquine and related antimalarial agents in human neutrophils: Implications for drug design. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 280(2), 884-893. Retrieved from https://www.webofscience.com/

Journal article

Characterization of the metabolites of carbamazepine in patient urine by liquid chromatography mass spectrometry

Maggs, J. L., Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (1997). Characterization of the metabolites of carbamazepine in patient urine by liquid chromatography mass spectrometry. DRUG METABOLISM AND DISPOSITION, 25(3), 275-280. Retrieved from https://www.webofscience.com/

Journal article

Antiprotozoal drugs

Pirmohamed, M., & Winstanley, P. A. (1997). Antiprotozoal drugs. Unknown Journal, 257-268. doi:10.1016/s0378-6080(05)80390-3

DOI
10.1016/s0378-6080(05)80390-3
Journal article

Characterisation of the toxic metabolite(s) of naphthalene (vol 114, pg 233, 1996)

Wilson, A. S., Davis, C. D., Williams, D. P., Buckpitt, A. R., Pirmohamed, M., & Park, B. K. (1997). Characterisation of the toxic metabolite(s) of naphthalene (vol 114, pg 233, 1996). TOXICOLOGY, 120(1), 75. Retrieved from https://www.webofscience.com/

Journal article

Mechanism of clozapine-induced agranulocytosis - Current status of research and implications for drug development

Pirmohamed, M., & Park, K. (1997). Mechanism of clozapine-induced agranulocytosis - Current status of research and implications for drug development. CNS DRUGS, 7(2), 139-158. doi:10.2165/00023210-199707020-00005

DOI
10.2165/00023210-199707020-00005
Journal article

Nurses' confidence in caring for patients with alcohol-related problems.

Brown, C., Pirmohamed, M., & Park, B. K. (1997). Nurses' confidence in caring for patients with alcohol-related problems.. Professional nurse (London, England), 13(2), 83-86.

Journal article

1996

Characterisation of the toxic metabolite(s) of naphthalene

Wilson, A. S., Davis, C. D., Williams, D. P., Buckpitt, A. R., Pirmohamed, M., & Park, B. K. (1996). Characterisation of the toxic metabolite(s) of naphthalene. TOXICOLOGY, 114(3), 233-242. doi:10.1016/S0300-483X(96)03515-9

DOI
10.1016/S0300-483X(96)03515-9
Journal article

Bioactivation of carbamazepine in the rat in vivo

Madden, S., Maggs, J. L., Kitteringham, N. R., Pirmohamed, M., & Park, B. K. (1996). Bioactivation of carbamazepine in the rat in vivo. British Journal of Clinical Pharmacology, 41(5).

Journal article

Glutathione S-transferase T1 polymorphism and susceptibility to carbamazepine hypersensitivity

Allott, R. L., Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (1996). Glutathione S-transferase T1 polymorphism and susceptibility to carbamazepine hypersensitivity. British Journal of Clinical Pharmacology, 41(5).

Journal article

Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: Studies, with cis-stilbene oxide, carbamazepine 10,11-epoxide and naphthalene

Kitteringham, N. R., Davis, C., Howard, N., Pirmohamed, M., & Park, B. K. (1996). Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: Studies, with cis-stilbene oxide, carbamazepine 10,11-epoxide and naphthalene. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 278(3), 1018-1027. Retrieved from https://www.webofscience.com/

Journal article

Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity.

Naisbitt, D. J., ONeill, P. M., Pirmohamed, M., & Park, B. K. (1996). Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 6(13), 1511-1516. doi:10.1016/S0960-894X(96)00260-0

DOI
10.1016/S0960-894X(96)00260-0
Journal article

Intracellular glutathione in the peripheral blood cells of HIV-infected patients: failure to show a deficiency

Pirmohamed, M., Williams, D., Tingle, M. D., Barry, M., Khoo, S. H., OʼMahony, C., . . . Park, B. K. (1996). Intracellular glutathione in the peripheral blood cells of HIV-infected patients: failure to show a deficiency. AIDS, 10(5), 501-507. doi:10.1097/00002030-199605000-00008

DOI
10.1097/00002030-199605000-00008
Journal article

Lack of association between schizophrenia and the CYP2D6 gene polymorphisms

Pirmohamed, M., Wild, M. J., Kitteringham, N. R., OBrien, K., Buchan, I. E., Back, D. J., & Park, B. K. (1996). Lack of association between schizophrenia and the CYP2D6 gene polymorphisms. AMERICAN JOURNAL OF MEDICAL GENETICS, 67(2), 236-237. doi:10.1002/ajmg.1320670205

DOI
10.1002/ajmg.1320670205
Journal article

Hydralazine-induced lupus: yet another autoantibody!

Pirmohamed, M. (1996). Hydralazine-induced lupus: yet another autoantibody!. Human & experimental toxicology, 15(4), 361-362. doi:10.1177/096032719601500413

DOI
10.1177/096032719601500413
Journal article

Hydralazine-induced lupus: Yet another autoantibody! Triplex-DNA stabilization by hydrazazine and the presence of anti-(triplex DNA) antibodies in patients treated with hydralazine - Comment

Pirmohamed, M. (1996). Hydralazine-induced lupus: Yet another autoantibody! Triplex-DNA stabilization by hydrazazine and the presence of anti-(triplex DNA) antibodies in patients treated with hydralazine - Comment. HUMAN & EXPERIMENTAL TOXICOLOGY, 15(4), 361-362. doi:10.1177/096032719601500413

DOI
10.1177/096032719601500413
Journal article

Idiosyncratic drug reactions - Metabolic bioactivation as a pathogenic mechanism

Pirmohamed, M., Madden, S., & Park, B. K. (1996). Idiosyncratic drug reactions - Metabolic bioactivation as a pathogenic mechanism. CLINICAL PHARMACOKINETICS, 31(3), 215-230. doi:10.2165/00003088-199631030-00005

DOI
10.2165/00003088-199631030-00005
Journal article

Intracellular glutathione in the peripheral blood cells of HIV-infected patients: Failure to show a deficiency

Pirmohamed, M., Williams, D., Tingle, M. D., Barry, M., Khoo, S. H., OMahony, C., . . . Park, B. K. (1996). Intracellular glutathione in the peripheral blood cells of HIV-infected patients: Failure to show a deficiency. AIDS, 10(5), 501-507. doi:10.1097/00002030-199605000-00008

DOI
10.1097/00002030-199605000-00008
Journal article

Investigation of the role of the TNF alpha gene polymorphism in alcoholic liver disease (ALD).

Allott, R. L., Quest, L. J., Pirmohamed, M., Kitteringham, N. R., Gilmore, I. T., & Park, B. K. (1996). Investigation of the role of the TNF alpha gene polymorphism in alcoholic liver disease (ALD).. In HEPATOLOGY Vol. 24 (pp. 1266). Retrieved from https://www.webofscience.com/

Conference Paper

Relevance of induction of human drug-metabolizing enzymes: Pharmacological and toxicological implications

Park, B. K., Kitteringham, N. R., Pirmohamed, M., & Tucker, G. T. (1996). Relevance of induction of human drug-metabolizing enzymes: Pharmacological and toxicological implications. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 41(6), 477-491. doi:10.1046/j.1365-2125.1996.03482.x

DOI
10.1046/j.1365-2125.1996.03482.x
Journal article

Relevance of induction of human drug-metabolizing enzymes: Pharmacological and toxicological implications (vol 41, pg 477, 1996)

Park, B. K., Kitteringham, N. R., Pirmohamed, M., & Tucker, G. T. (1996). Relevance of induction of human drug-metabolizing enzymes: Pharmacological and toxicological implications (vol 41, pg 477, 1996). BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 42(4), U1. Retrieved from https://www.webofscience.com/

Journal article

The effect of fluconazole and ketoconazole on the metabolism of sulphamethoxazole

Gill, H. J., Maggs, J. L., Madden, S., Pirmohamed, M., & Park, K. (1996). The effect of fluconazole and ketoconazole on the metabolism of sulphamethoxazole. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 42(3), 347-353. doi:10.1046/j.1365-2125.1996.40110.x

DOI
10.1046/j.1365-2125.1996.40110.x
Journal article

Toxicology elsewhere

Pirmohamed, M. (1996). Toxicology elsewhere. Human &amp; Experimental Toxicology, 15(4), 361-362. doi:10.1177/096032719601500413

DOI
10.1177/096032719601500413
Journal article

1995

The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man

Maggs, J. L., Williams, D., Pirmohamed, M., & Park, B. K. (1995). The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 275(3), 1463-1475. Retrieved from https://www.webofscience.com/

Journal article

GENETIC-ANALYSIS OF MICROSOMAL EPOXIDE HYDROLASE IN PATIENTS WITH CARBAMAZEPINE HYPERSENSITIVITY

GREEN, V. J., PIRMOHAMED, M., KITTERINGHAM, N. R., GAEDIGK, A., GRANT, D. M., BOXER, M., . . . PARK, B. K. (1995). GENETIC-ANALYSIS OF MICROSOMAL EPOXIDE HYDROLASE IN PATIENTS WITH CARBAMAZEPINE HYPERSENSITIVITY. BIOCHEMICAL PHARMACOLOGY, 50(9), 1353-1359. doi:10.1016/0006-2952(95)02009-8

DOI
10.1016/0006-2952(95)02009-8
Journal article

KINETIC-PARAMETERS OF LYMPHOCYTE MICROSOMAL EPOXIDE HYDROLASE IN CARBAMAZEPINE HYPERSENSITIVE PATIENTS - ASSESSMENT BY RADIOMETRIC HPLC

DAVIS, C. D., PIRMOHAMED, M., KITTERINGHAM, N. R., ALLOTT, R. L., SMITH, D., & PARK, B. K. (1995). KINETIC-PARAMETERS OF LYMPHOCYTE MICROSOMAL EPOXIDE HYDROLASE IN CARBAMAZEPINE HYPERSENSITIVE PATIENTS - ASSESSMENT BY RADIOMETRIC HPLC. BIOCHEMICAL PHARMACOLOGY, 50(9), 1361-1366. doi:10.1016/0006-2952(95)02008-X

DOI
10.1016/0006-2952(95)02008-X
Journal article

Antiprotozoal drugs

Pirmohamed, M., & Winstanley, P. A. (1995). Antiprotozoal drugs. Unknown Journal, 262-272. doi:10.1016/s0378-6080(05)80153-9

DOI
10.1016/s0378-6080(05)80153-9
Journal article

Conference reports - Therapeutics 1995 - Abstracts

Pirmohamed, M., & Martin, U. (1995). Conference reports - Therapeutics 1995 - Abstracts. JOURNAL OF THE ROYAL COLLEGE OF PHYSICIANS OF LONDON, 29(6), 530-534. Retrieved from https://www.webofscience.com/

Journal article

GLUTATHIONE-S-TRANSFERASE-MU GENOTYPE (GSTM1-ASTERISK-0) IN ALZHEIMERS PATIENTS WITH TACRINE TRANSAMINITIS

GREEN, V. J., PIRMOHAMED, M., KITTERINGHAM, N. R., KNAPP, M. J., & PARK, B. K. (1995). GLUTATHIONE-S-TRANSFERASE-MU GENOTYPE (GSTM1-ASTERISK-0) IN ALZHEIMERS PATIENTS WITH TACRINE TRANSAMINITIS. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 39(4), 411-415. doi:10.1111/j.1365-2125.1995.tb04470.x

DOI
10.1111/j.1365-2125.1995.tb04470.x
Journal article

Genetic polymorphism of cytochrome P4502E1 and risk of alcoholic liver disease in Caucasians

Pirmohamed, M., Kitteringham, N. R., Quest, L. J., Allott, R. L., Green, V. J., Gilmore, I. T., & Park, B. K. (1995). Genetic polymorphism of cytochrome P4502E1 and risk of alcoholic liver disease in Caucasians. PHARMACOGENETICS, 5(6), 351-357. doi:10.1097/00008571-199512000-00003

DOI
10.1097/00008571-199512000-00003
Journal article

METABOLISM AND BIOACTIVATION OF CLOZAPINE BY HUMAN LIVER IN-VITRO

PIRMOHAMED, M., WILLIAMS, D., MADDEN, S., TEMPLETON, E., & PARK, B. K. (1995). METABOLISM AND BIOACTIVATION OF CLOZAPINE BY HUMAN LIVER IN-VITRO. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 272(3), 984-990. Retrieved from https://www.webofscience.com/

Journal article

Metabolism and bioactivation of clozapine by human liver in vitro.

Pirmohamed, M., Williams, D., Madden, S., Templeton, E., & Park, B. K. (1995). Metabolism and bioactivation of clozapine by human liver in vitro.. J Pharmacol Exp Ther., 3(273), 984-990.

Journal article

The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity

Park, B. K., Pirmohamed, M., & Kitteringham, N. R. (1995). The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity. PHARMACOLOGY & THERAPEUTICS, 68(3), 385-424. doi:10.1016/0163-7258(95)02013-6

DOI
10.1016/0163-7258(95)02013-6
Journal article

Therapeutics 1995.

Pirmohamed, M., & Martin, U. (1995). Therapeutics 1995.. Journal of the Royal College of Physicians of London, 29(6), 530-534.

Journal article

1994

INVESTIGATION OF MECHANISMS IN TOXIC EPIDERMAL NECROLYSIS INDUCED BY CARBAMAZEPINE

FRIEDMANN, P. S., STRICKLAND, I., PIRMOHAMED, M., & PARK, B. K. (1994). INVESTIGATION OF MECHANISMS IN TOXIC EPIDERMAL NECROLYSIS INDUCED BY CARBAMAZEPINE. ARCHIVES OF DERMATOLOGY, 130(5), 598-604. doi:10.1001/archderm.130.5.598

DOI
10.1001/archderm.130.5.598
Journal article

Investigation of mechanisms in toxic epidermal necrolysis induced by carbamazepine.

Friedmann, P. S., Strickland, I., Pirmohamed, M., & Park, B. K. (1994). Investigation of mechanisms in toxic epidermal necrolysis induced by carbamazepine.. Archives of dermatology, 130(5), 598-604. doi:10.1001/archderm.1994.01690050066011

DOI
10.1001/archderm.1994.01690050066011
Journal article

ASSOCIATION BETWEEN CYTOCHROME-P450-2E1 (CYP2E1) RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM AND ALCOHOLIC LIVER-DISEASE IN CAUCASIANS

PIRMOHAMED, M., QUEST, L. J., KITTERINGHAM, N. R., ALLOTT, R. A., GILMORE, I. T., & PARK, B. K. (1994). ASSOCIATION BETWEEN CYTOCHROME-P450-2E1 (CYP2E1) RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM AND ALCOHOLIC LIVER-DISEASE IN CAUCASIANS. In HEPATOLOGY Vol. 20 (pp. A317). Retrieved from https://www.webofscience.com/

Conference Paper

Antiprotozoal drugs

Pirmohamed, M., & Winstanley, P. A. (1994). Antiprotozoal drugs. Unknown Journal, 286-298. doi:10.1016/s0378-6080(05)80273-9

DOI
10.1016/s0378-6080(05)80273-9
Journal article

BIOACTIVATION AND BIOINACTIVATION OF DRUGS AND DRUG METABOLITES - RELEVANCE TO ADVERSE DRUG-REACTIONS

PARK, B. K., PIRMOHAMED, M., TINGLE, M. D., MADDEN, S., & KITTERINGHAM, N. R. (1994). BIOACTIVATION AND BIOINACTIVATION OF DRUGS AND DRUG METABOLITES - RELEVANCE TO ADVERSE DRUG-REACTIONS. TOXICOLOGY IN VITRO, 8(4), 613-621. doi:10.1016/0887-2333(94)90029-9

DOI
10.1016/0887-2333(94)90029-9
Journal article

LYMPHOCYTE MICROSOMAL EPOXIDE HYDROLASE IN PATIENTS ON CARBAMAZEPINE THERAPY

PIRMOHAMED, M., ALLOTT, R., GREEN, V. J., KITTERINGHAM, N. R., CHADWICK, D., & PARK, B. K. (1994). LYMPHOCYTE MICROSOMAL EPOXIDE HYDROLASE IN PATIENTS ON CARBAMAZEPINE THERAPY. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 37(6), 577-581. doi:10.1111/j.1365-2125.1994.tb04307.x

DOI
10.1111/j.1365-2125.1994.tb04307.x
Journal article

THE ROLE OF ACTIVE METABOLITES IN DRUG TOXICITY

PIRMOHAMED, M., KITTERINGHAM, N. R., & PARK, B. K. (1994). THE ROLE OF ACTIVE METABOLITES IN DRUG TOXICITY. DRUG SAFETY, 11(2), 114-144. doi:10.2165/00002018-199411020-00006

DOI
10.2165/00002018-199411020-00006
Journal article

1993

AN INVESTIGATION OF THE FORMATION OF CYTOTOXIC, GENOTOXIC, PROTEIN-REACTIVE AND STABLE METABOLITES FROM NAPHTHALENE BY HUMAN LIVER-MICROSOMES

TINGLE, M. D., PIRMOHAMED, M., TEMPLETON, E., WILSON, A. S., MADDEN, S., KITTERINGHAM, N. R., & PARK, B. K. (1993). AN INVESTIGATION OF THE FORMATION OF CYTOTOXIC, GENOTOXIC, PROTEIN-REACTIVE AND STABLE METABOLITES FROM NAPHTHALENE BY HUMAN LIVER-MICROSOMES. BIOCHEMICAL PHARMACOLOGY, 46(9), 1529-1538. doi:10.1016/0006-2952(93)90319-R

DOI
10.1016/0006-2952(93)90319-R
Journal article

INTERACTION OF METOPROLOL AND FLUOXETINE

WALLEY, T., PIRMOHAMED, M., PROUDLOVE, C., & MAXWELL, D. (1993). INTERACTION OF METOPROLOL AND FLUOXETINE. LANCET, 341(8850), 967-968. doi:10.1016/0140-6736(93)91265-N

DOI
10.1016/0140-6736(93)91265-N
Journal article

LACK OF INTERACTION BETWEEN SULFASALAZINE AND CIMETIDINE IN PATIENTS WITH RHEUMATOID-ARTHRITIS

PIRMOHAMED, M., COLEMAN, M. D., GALVANI, D., BUCKNALL, R. C., BRECKENRIDGE, A. M., & PARK, B. K. (1993). LACK OF INTERACTION BETWEEN SULFASALAZINE AND CIMETIDINE IN PATIENTS WITH RHEUMATOID-ARTHRITIS. BRITISH JOURNAL OF RHEUMATOLOGY, 32(3), 222-226. Retrieved from https://www.webofscience.com/

Journal article

Antiprotozoal drugs

Pirmohamed, M., & Winstanley, P. A. (1993). Antiprotozoal drugs. Unknown Journal, 325-336. doi:10.1016/s0378-6080(05)80212-0

DOI
10.1016/s0378-6080(05)80212-0
Journal article

PREDICTION OF IDIOSYNCRATIC DRUG REACTIONS

Pirmohamed, M., & Park, B. K. (1993). PREDICTION OF IDIOSYNCRATIC DRUG REACTIONS. Adverse Drug Reaction Bulletin, 163(1), 615. doi:10.1097/00012995-199312000-00001

DOI
10.1097/00012995-199312000-00001
Journal article

1992

THE EFFECT OF ENZYME-INDUCTION ON THE CYTOCHROME-P450-MEDIATED BIOACTIVATION OF CARBAMAZEPINE BY MOUSE-LIVER MICROSOMES

PIRMOHAMED, M., KITTERINGHAM, N. R., BRECKENRIDGE, A. M., & PARK, B. K. (1992). THE EFFECT OF ENZYME-INDUCTION ON THE CYTOCHROME-P450-MEDIATED BIOACTIVATION OF CARBAMAZEPINE BY MOUSE-LIVER MICROSOMES. BIOCHEMICAL PHARMACOLOGY, 44(12), 2307-2314. doi:10.1016/0006-2952(92)90674-8

DOI
10.1016/0006-2952(92)90674-8
Journal article

AN INVESTIGATION OF THE FORMATION OF CYTOTOXIC, PROTEIN-REACTIVE AND STABLE METABOLITES FROM CARBAMAZEPINE INVITRO

PIRMOHAMED, M., KITTERINGHAM, N. R., GUENTHNER, T. M., BRECKENRIDGE, A. M., & PARK, B. K. (1992). AN INVESTIGATION OF THE FORMATION OF CYTOTOXIC, PROTEIN-REACTIVE AND STABLE METABOLITES FROM CARBAMAZEPINE INVITRO. BIOCHEMICAL PHARMACOLOGY, 43(8), 1675-1682. doi:10.1016/0006-2952(92)90696-G

DOI
10.1016/0006-2952(92)90696-G
Journal article

Bioactivation of lofepramine to a cytotoxic metabolite by human and mouse liver microsomes

Pirmohamed, M., Templeton, E., Breckenridge, A. M., & Park, B. K. (1992). Bioactivation of lofepramine to a cytotoxic metabolite by human and mouse liver microsomes. In British Journal of Clinical Pharmacology Vol. 33.

Conference Paper

DETECTION OF AN AUTOANTIBODY DIRECTED AGAINST HUMAN LIVER MICROSOMAL PROTEIN IN A PATIENT WITH CARBAMAZEPINE HYPERSENSITIVITY

PIRMOHAMED, M., KITTERINGHAM, N. R., BRECKENRIDGE, A. M., & PARK, B. K. (1992). DETECTION OF AN AUTOANTIBODY DIRECTED AGAINST HUMAN LIVER MICROSOMAL PROTEIN IN A PATIENT WITH CARBAMAZEPINE HYPERSENSITIVITY. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 33(2), 183-186. doi:10.1111/j.1365-2125.1992.tb04022.x

DOI
10.1111/j.1365-2125.1992.tb04022.x
Journal article

IDIOSYNCRATIC DRUG-REACTIONS - A MECHANISTIC EVALUATION OF RISK-FACTORS

PARK, B. K., PIRMOHAMED, M., & KITTERINGHAM, N. R. (1992). IDIOSYNCRATIC DRUG-REACTIONS - A MECHANISTIC EVALUATION OF RISK-FACTORS. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 34(5), 377-395. doi:10.1111/j.1365-2125.1992.tb05647.x

DOI
10.1111/j.1365-2125.1992.tb05647.x
Journal article

IDIOSYNCRATIC REACTIONS TO ANTIDEPRESSANTS - A REVIEW OF THE POSSIBLE MECHANISMS AND PREDISPOSING FACTORS

PIRMOHAMED, M., KITTERINGHAM, N. R., & PARK, B. K. (1992). IDIOSYNCRATIC REACTIONS TO ANTIDEPRESSANTS - A REVIEW OF THE POSSIBLE MECHANISMS AND PREDISPOSING FACTORS. PHARMACOLOGY & THERAPEUTICS, 53(1), 105-125. doi:10.1016/0163-7258(92)90046-3

DOI
10.1016/0163-7258(92)90046-3
Journal article

In vitro bioactivation of clozapine to a chemically reactive metabolite by human and mouse liver microsomes

Pirmohamed, M., Templeton, E., Breckenridge, A. M., & Park, B. K. (1992). In vitro bioactivation of clozapine to a chemically reactive metabolite by human and mouse liver microsomes. In British Journal of Clinical Pharmacology Vol. 34.

Conference Paper

1991

CARBAMAZEPINE-HYPERSENSITIVITY - ASSESSMENT OF CLINICAL AND INVITRO CHEMICAL CROSS-REACTIVITY WITH PHENYTOIN AND OXCARBAZEPINE

PIRMOHAMED, M., GRAHAM, A., ROBERTS, P., SMITH, D., CHADWICK, D., BRECKENRIDGE, A. M., & PARK, B. K. (1991). CARBAMAZEPINE-HYPERSENSITIVITY - ASSESSMENT OF CLINICAL AND INVITRO CHEMICAL CROSS-REACTIVITY WITH PHENYTOIN AND OXCARBAZEPINE. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 32(6), 741-749. Retrieved from https://www.webofscience.com/

Journal article

ANALYSIS OF MICROSOMAL EPOXIDE HYDROLASE LEVELS IN HUMAN TISSUES USING MONOCLONAL-ANTIBODIES

GUENTHNER, T. M., KUK, J., NGUYEN, M., WHEELER, C., & PIRMOHAMED, M. (1991). ANALYSIS OF MICROSOMAL EPOXIDE HYDROLASE LEVELS IN HUMAN TISSUES USING MONOCLONAL-ANTIBODIES. In FASEB JOURNAL Vol. 5 (pp. A1570). Retrieved from https://www.webofscience.com/

Conference Paper

DIRECT AND METABOLISM-DEPENDENT TOXICITY OF SULFASALAZINE AND ITS PRINCIPAL METABOLITES TOWARDS HUMAN ERYTHROCYTES AND LEUKOCYTES

PIRMOHAMED, M., COLEMAN, M. D., HUSSAIN, F., BRECKENRIDGE, A. M., & PARK, B. K. (1991). DIRECT AND METABOLISM-DEPENDENT TOXICITY OF SULFASALAZINE AND ITS PRINCIPAL METABOLITES TOWARDS HUMAN ERYTHROCYTES AND LEUKOCYTES. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 32(3), 303-310. doi:10.1111/j.1365-2125.1991.tb03903.x

DOI
10.1111/j.1365-2125.1991.tb03903.x
Journal article

Use of an in vitro lymphocyte cytotoxicity assay to assess the effects of carbamazepine (CBZ), phenytoin (DPH) and oxcarbazepine (OXCZ) in carbamazepine-hypersensitive patients

Pirmohamed, M., Graham, A., Roberts, P., Smith, D., Chadwick, D. C., Breckenridge, A. M., & Park, B. K. (1991). Use of an in vitro lymphocyte cytotoxicity assay to assess the effects of carbamazepine (CBZ), phenytoin (DPH) and oxcarbazepine (OXCZ) in carbamazepine-hypersensitive patients. In British Journal of Clinical Pharmacology Vol. 31.

Conference Paper

1990

PRESCRIBING IN EPILEPSY

PIRMOHAMED, M. (1990). PRESCRIBING IN EPILEPSY. PRACTITIONER, 234(1497), 1070-1072. Retrieved from https://www.webofscience.com/

Journal article

1989

USE OF ADRENAL ARTERIAL EMBOLIZATION IN SEVERE ACTH-DEPENDENT CUSHINGS-SYNDROME

BLUNT, S. B., PIRMOHAMED, M., CHATTERJEE, V. K. K., BURRIN, J. M., ALLISON, D. J., & JOPLIN, G. F. (1989). USE OF ADRENAL ARTERIAL EMBOLIZATION IN SEVERE ACTH-DEPENDENT CUSHINGS-SYNDROME. POSTGRADUATE MEDICAL JOURNAL, 65(766), 575-579. doi:10.1136/pgmj.65.766.575

DOI
10.1136/pgmj.65.766.575
Journal article

1988

Undated

Use of Sodium Valproate and Other Anti-Seizure Medications in England and Wales During the COVID-19 Pandemic: A Population-Level Analysis of 60 Million Individuals

Dale, C., Takhar, R., Fan, Y. Y., Torabi, F., Kim, S., Lambarth, A., . . . Consortium, C. -C. -U. (n.d.). Use of Sodium Valproate and Other Anti-Seizure Medications in England and Wales During the COVID-19 Pandemic: A Population-Level Analysis of 60 Million Individuals.

Journal article