Professional Activities
Leadership positions (past and present):
1995-2020 Director, Mersey Yellow Card Monitoring Centre for Adverse Drug Reactions
1996 to now Honorary Consultant Physician at the Liverpool University Hospital Foundation NHS Trust
2001-2020 Programme Director, Clinical Pharmacology and Therapeutics, Mersey/North West Deanery.
2001 to now Regional Specialty Advisor, Clinical Pharmacology and Therapeutics, Mersey/North West Deanery.
2005-2020 Chair, Pharmacovigilance Expert Advisory Group (sub-committee of the Commission on Human Medicines) and member of the Commission on Human Medicines
2007 to now NHS Chair of Pharmacogenetics, University of Liverpool
2009 to now Director of the Wolfson Centre for Personalised Medicine, University of Liverpool
2010 to now Director of the NW England MRC Clinical Pharmacology Training Scheme, Universities of Liverpool and Manchester
2010 to now Chair of the UK Pharmacogenetics and Stratified Medicine Network
2010-2015 Head of Department, Molecular and Clinical Pharmacology, University of Liverpool
2013-2018 Associate Pro Vice Chancellor (Clinical Research), University of Liverpool
2014 to now Director of the Centre for Drug Safety Science, University of Liverpool
2015-2018 Executive Director, Liverpool Health Partners
2015 to now Patron, SJS Awareness UK Charity
2018 to now Member of the Governing Council of the Medical Research Council
2019-2023 Non-Executive Director NHS England, and Chair of the NHS England Quality Committee (2022-2023)
2019 to now Member, Bosch Health Campus International Advisory Board
2019 to now Patron, Genomic Medical Foundation, UK
2020 to now Director of Health Data Research (HDR) North
2020 to now Medical Trustee, British Heart Foundation
2020-2021 President, British Pharmacological Society
2021 to now Member, Scientific Advisory Board, Our Future Health
2020-2023 Chair, Vaccine Benefit-Risk Expert Working Group (sub-committee of the Commission on Human Medicines)
2021 to now Chair of the Commission on Human Medicines
2021 to now Vie Chair of Qatar Precision Health Initiative
2023-2024 President of the Association of Physicians
2023 to now Chair of Cancer Vaccine Expert Working Group (sub-committee of the Commission on Human Medicines, advising the MHRA)
2023 to now Chair of Prix Galien UK
Conference Roles
- Designer Medicines, by Invitation (ASE, 2008)
- Pharmacogenetic prediction of adverse drug reactions, by Invitation (ASCEPT, 2007)
- Adverse drug reactions: from patients to genes, by Invitation (ASCEPT, 2007)
- Pharmacogenomics and pharmacovigilance, by Invitation (Indo-French Collaboration, 2007)
- Pharmacogenetics of adverse drug reactions and role in pharmacovigilance, by Invitation (University of Canberrra, 2007)
- Pharmacogenetics: current situation, challenges and opportunities, by Invitation (University of Bendigo, Australia, 2007)
- Pharmacogenomics and the cardiovascular system: challenges and opportunities, by Invitation (Baker Heart Research Institute, Melbourne, Australia, 2007)
- Idiosyncratic adverse drug reactions: from molecule to man, by Invitation (St Vincent's Hospital, Sydney, Australia, 2007)
- Adverse drug reactions, by Invitation (Therapeutics and Goods Administration. Canberra, Australia, 2007)
- Pharmacogenetics: current status, future challenges, by Invitation (ESPR, 2007)
- Pharmacogenetics of drug hypersensitivity, by Invitation (ISOP, 2007)
- Cytochrome P450 testing: A case study, by Invitation (Academy of Medical Sciences, 2007)
- Safety Monitoring, by Invitation (MHRA, 2007)
- Personalising risk for the patient over the next 20 year., by Invitation (BrAPP, FPS, RSM, 2007)
- Anti-epileptic drugs: past, present and future, by Invitation (ER-UK, 2007)
- Will pharmacogenetics ever have a role in pharmacovigilance? , by Invitation (EACPT, 2007)
- Adverse drug reactions: which one’s can we predict? The clinical perspective, by Invitation (Gordon Research Conferences, 2007)
- Pharmacogenetics: present situation and perspectives on clinical application, by Invitation (ESF, 2007)
- The skin, drugs and T-cells: a significant, but sometimes uncomfortable, threesome, by Invitation (Toronto Western Hospital, 2007)
- Pharmacogenetics in drug hypersensitivity, by Invitation (Swiss Society of Allergy and Immunology, and the Swiss Society of Dermatology and Venereology, 2007)
- Pharmacogenetics of adverse drug reactions, by Invitation (Conference Organisers, 2007)
- Pharmacogenetics in Gastroenterology, by Invitation (University of Nottingham, 2007)
- Pharmacogenetics: hype or hope? , by Invitation (European College of Neuro-Psychopharmacology , 2007)
- Pharmacogenetics of adverse drug reactions, by Invitation (Royal Society of Medicine, 2007)
- Yellow cards – moving forwards, by Invitation (MHRA, 2007)
- Hapten-independent T-cell drug reactions: evidence and implications, by Invitation (AAAAI, 2007)
- Pharmacogenetics: a clinical perspective, by Invitation (Epidauros, 2007)
- Recent initiatives in pharmacogenetics in the UK, by Invitation (NIH Pharmacogenetics Research Network, 2006)
- The future of pharmacogenetics and its impact on healthcare systems, by Invitation (MHRA, 2006)
- Pharmacogenetics in practice: the challenge of translation, by Invitation (Generation Scotland, 2006)
- Genetic prediction of adverse drug reactions, by Invitation (ISOP, 2006)
- Pharmacogenetics in clinical practice: the problem of translation, by Invitation (Dutch Royal Pharmaceutical Society, 2006)
- Adverse drug reactions: incidence and role of pharmacists, by Invitation (UK Medicine Information Pharmacists, 2006)
- Pharmacogenetics and adverse drug reactions, by Invitation (RPSGB, 2006)
- Personalised pills. From Pythagoras to the present, by Invitation (British Pharmacological Society, 2006)
- Pharmacogenetics: theoretical background and practical problems, by Invitation (IUPHAR, 2006)
- Will pharmacogenetics ever have a role in pharmacovigilanc? , by Invitation (Conference Organisers, 2006)
- Why are some patients harmed by a medicine while others are not? , by Invitation (British Society for Ecological Medicine, 2006)
- Individual basis of susceptibility to adverse drug reactions, by Invitation (ISSX, 2006)
- Genetic basis of adverse drug reactions, by Invitation (DG Research, 2006)
- Drug safety: scale of the problems and developing solutions, by Invitation (Southport District General Hospital, 2006)
- Pharmacogenomics of herbal medicines, by Invitation (Conference Organisers, 2006)
- Recent advances in pharmaco- and immunogenetics, by Invitation (Conference Organisers, 2006)
- This is the drug for you, Madam, by Invitation (Epilepsy Research Foundation, 2006)
- Optimal genotyping strategies in pharmacogenomics, by Invitation (Genomes to Systems Conference. Manchester, 2006)
- Mechanisms of drug-induced hepatotoxicity, by Invitation (British Co-Infection Association, 2006)
- Pharmacogenetics of HIV therapy, by Invitation (London IDEAS Genetics Knowledge Park, 2005)
- Pharmacogenetics, by Invitation (Cambridge Genetics Knowledge Park, 2005)
- What are personalised medicines and what will they mean to the dynamics of healthcare? , by Invitation (Tech-Link Ireland, 2005)
- Pharmacogenetics of adverse drug reactions, by Invitation (PK-UK, 2005)
- Drug safety: a continuing public health problem, by Invitation (Royal College of Physiciana, 2005)
- Epilepsy pharmacogenetics, by Invitation (Banbury Centre, Cold Spring Harbor Laboratory, 2005)
- Drug Safety: Defining the Problems and Developing Solutions, by Invitation (University of Toronto, 2005)
- Immune-mediated drug hypersensitivity: an overview, by Invitation (British Society of Allergy and Clinical Immunology , 2005)
- Drug-induced liver injury: working towards better diagnostic and preventive strategies, by Invitation (Gordon Research Conferences, 2005)
- Genetic aspects of drug-induced hypersensitivity reactions, by Invitation (Gordon Research Conferences, 2005)
- Pharmacogenetics of antiepileptic drugs, by Invitation (Royal Liverpool Childrens Hospital, 2005)
- Drug interactions: new mechanisms, new issues, by Invitation (Royal College of Physicians of Edinburgh, 2005)
- Pharmacogenomics: current status, by Invitation (University of Edinburgh, 2005)
- Pharmacogenetics and antiviral drugs, by Invitation (IFCC-FESCC , 2005)
- Pharmacogenetics: current status and future potential, by Invitation (MerseyBio, 2005)
- Pharmacogenetics: Study Designs, Potential Problems and Possible Solutions, by Invitation (Drug Safety Research Unit, 2005)
- Pharmacogenetics and Clinical Practice: Challenges and Prospects, by Invitation (GlaxoSmithKline Pharmaceuticals, 2005)
- New Insights into the Pathogenesis of Allergic Drug Reactions, by Invitation (American Academy of Allergy, Asthma and Immunology, 2005)
- Cardiovascular pharmacogenetics, by Invitation (London Hypertension Society, 2005)
- Principles of pharmacogenetics, problems and possible solutions, by Invitation (British Society of Gastroenterology, 2005)
- Pharmacovigilance in the future, by Invitation (EMEA, 2005)
- Immune Pathogenesis of Drug-Induced Liver Disease, by Invitation (Swiss Society for Allergology and Immunology, 2005)
Editorships
- Pharmacogenomics Journal, 2015 – (Section Editor,)
- Journal of Gerontology and Geriatrics, June 2015 - (Editorial Board,, 2015 - present)
- ExpeReview of Precision Medicine and Drug Development, 2015 – (Editorial Board,, 2015 - present)
- , Translational Medicine, 2014 - (Editorial Board, 2014 - present)
- , Cardio-Debate.com, 2013 (Editorial Board, 2013 - present)
- Current Trends in Genomic Medicine, 2013 - (Editorial Board,, 2013 - present)
- , Health Policy and Technology Journal, 2012 - (Advisory Board, 2012 - present)
- Cardiogenetics, 2011 – (Editorial Board,, 2011 - present)
- Therapeutic Advances in Drug Safety, (Editorial Board,, 2010 - present)
- Genome Medicine, 2009 – (Editorial Board,, 2009 - present)
- International Medical Case Reports Journal, (Editorial Board,, 2009 - present)
- Pharmacological Research, 2008 – 2010 (Editorial Board,, 2008 - 2010)
- British Journal of Clinical Pharmacology, 1999-2007 (Invited Executive Editorial Board,, 1999 - 2007)
- Frontiers in Pharmacogenetics (Invited Associate Editor)
- Pharmacogenomics (Editorial Board Member, 2008 - present)
- Pharmaceutical Research (Editorial Board Member, 2007 - present)
- Pharmacogenetics & Genomics (Editorial Board Member, 2007 - present)
- Current Drug Safety (Editorial Board Member, 2005 - present)
- Therapeutics and Clinical Risk Management (Editorial Board Member, 2004 - present)
- Expert Opinion on Pharmacotherapy (Editorial Board Member, 2004 - present)
- Drug Safety (Editorial Board Member, 2004 - present)
- Expert Opinion on Drug Safety (Editorial Board Member, 2002 - present)
- Postgraduate Medical Journal (Editorial Board, 1999 - 2006)
Examination Roles
- MD thesis, 2003; resubmission 2006 (PhD)
- PhD thesis, University of Tartu, 2020 (2020)
- PhD thesis, University of Antwerp, 2020 (2020)
- PhD thesis, Newcastle University, 2015 (2015)
- University of Melbourne, PhD thesis, King’s College, London, 2015; re-examined 2017. (2015)
- PhD thesis, University of Melbourne, 2011 (2011)
- PhD thesis, University of Dundee, 2010 (2010)
- MD thesis, University of London, 2009 (PhD, 2009)
- PhD thesis, University of Cambridge, 2008 (2008)
- MD thesis, University of Nottingham, 2007 (PhD, 2007)
- PhD thesis, University of Newcastle-upon-Tyne, 2007 (2007)
- MD thesis, University of Cardiff, 2007. (PhD, 2007)
- PhD thesis, Murdoch University, Australia, 2007 (2007)
- PhD thesis, University College London, 2006 (2006)
- PhD thesis, University of London, 2006 (2006)
- MSc thesis, University of Dundee, 2005 (PhD, 2005)
- Medicine MB ChB, University of St Andrews, 2004-2007 (PhD, 2004 - 2007)
- PhD thesis, University of Newcastle-upon-Tyne, 2004 (2004)
- PhD thesis, University of Manchester, 2003 (2003)
- Medicine MB BCh, 2001 - 2005 (PhD, 2001 - 2005)
- PhD thesis 2000 (2000)
- Medicine MB BCh, (PhD, 1999 - present)
- Medicine MB ChB, 1998-2001 (PhD, 1998 - 2021)
- MSc Pharmacovigilance,, 1996-2000 (MPhil, 1996 - 2000)
- University of Cambridge, UK, PhD (2007)
- University College London, UK, PhD (2006)
- University of Newcastle upon Tyne, PhD (2006)
- Cardiff University (Wales), MD (PGT, 2006)
- University of St Andrews, MBBS (UG, 2006)
- Murdoch University Australia, PhD (2006)
- University of St Andrews, MBBS (UG, 2005)
- University of Newcastle upon Tyne, PhD (2005)
- University of Dundee, MSc (PGT, 2004)
Professional Body Memberships
- (FELLOW, 2018 - present)
- (Honorary Fellow, 2018 - present)
- (Member, 2016 - present)
- (FELLOW, 2009 - present)
- British Medical Association (Member)
- Medical Protection Society (Member)
- British Pharmacological Society (Fellow)
- Liverpool Medical Institution (Member)
- Fellowship of Postgraduate Medicine (Fellow)
- Medical Research Society (Member)
- Medical Council on Alcohol (Member, 2005 - present)
- Association of Physicians (fellow, 2005 - present)
- Royal College of Physicians (Fellow, 2000 - present)
- Royal College of Physicians (Edinburgh) (Fellow, 1999 - present)
- Royal College of Physicians (Member, 1988 - present)