Publications
2025
The small molecule inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Fresneda Alarcon, M., Abdullah, G. A., Nolan, A., Linford, C., Meschis, M. M., Cross, A. L., . . . Wright, H. L. (n.d.). The small molecule inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release. Clinical and Experimental Immunology. doi:10.1093/cei/uxaf012
Hypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239
Kelly, C. L., Wydrzynska, M., Phelan, M. M., Osharovich, S., Delikatny, E. J., Sée, V., & Poptani, H. (n.d.). Hypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239. Metabolites, 15(2), 76. doi:10.3390/metabo15020076
2024
Serum metabolomics identifies unique inflammatory signatures to distinguish rheumatoid arthritis responders and non-responders to TNF inhibitor therapy
New Insights into Healthy Ageing, Inflammageing and Frailty using Metabolomics
Abdullah, G., Akpan, A., Phelan, M., & Wright, H. (2024). New Insights into Healthy Ageing, Inflammageing and Frailty using Metabolomics. Frontiers in Aging.
Diagnostic utility of clinicodemographic, biochemical and metabolite variables to identify viable pregnancies in a symptomatic cohort during early gestation.
Hill, C. J., Phelan, M. M., Dutton, P. J., Busuulwa, P., Maclean, A., Davison, A. S., . . . Hapangama, D. K. (2024). Diagnostic utility of clinicodemographic, biochemical and metabolite variables to identify viable pregnancies in a symptomatic cohort during early gestation.. Scientific reports, 14(1), 11172. doi:10.1038/s41598-024-61690-3
The CcpNmr Analysis Simulated Metabolomics Database (CASMDB): An Open-Source Collection of Metabolite Annotation Data for 1D<sup>1</sup>H NMR-Based Metabolomics
Inhibition of glioblastoma cell proliferation and invasion by the choline-kinase inhibitor JAS239 varies with cell type and hypoxia.
2023
The small molecule inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Determining predictive metabolomic biomarkers of meniscal injury in dogs with cranial cruciate ligament rupture.
Pye, C., Green, D., Anderson, J., Fitzgerald, M., Phelan, M., Comerford, E., & Peffers, M. (2023). Determining predictive metabolomic biomarkers of meniscal injury in dogs with cranial cruciate ligament rupture.. Journal of Small Animal Practice.
Airway metabolic profiling during <i>Streptococcus pneumoniae</i> infection identifies branched chain amino acids as signatures of upper airway colonisation
Green, A. E., Pottenger, S., Monshi, M. S., Barton, T. E., Phelan, M., & Neill, D. R. (2023). Airway metabolic profiling during <i>Streptococcus pneumoniae</i> infection identifies branched chain amino acids as signatures of upper airway colonisation. PLOS PATHOGENS, 19(9). doi:10.1371/journal.ppat.1011630
Acute heat stress amplifies exercise-induced metabolomic perturbations and reveals variation in circulating amino acids in endurance-trained males.
Bennett, S., Brocherie, F., Phelan, M. M., Tiollier, E., Guibert, E., Morales-Artacho, A. J., . . . Owens, D. J. (2023). Acute heat stress amplifies exercise-induced metabolomic perturbations and reveals variation in circulating amino acids in endurance-trained males.. Experimental physiology, 108(6), 838-851. doi:10.1113/ep090911
Serum 1H nuclear magnetic resonance–based metabolomics of sole lesion development in Holstein cows
Barden, M., Phelan, M. M., Hyde, R., Anagnostopoulos, A., Griffiths, B. E., Bedford, C., . . . Oikonomou, G. (2023). Serum 1H nuclear magnetic resonance–based metabolomics of sole lesion development in Holstein cows. Journal of dairy science, S0022-0302(23)00097-8. doi:10.3168/jds.2022-22681
CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells.
Aye, C. -C., Hammond, D. E., Rodriguez-Cuenca, S., Doherty, M. K., Whitfield, P. D., Phelan, M. M., . . . Mora, S. (2023). CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells.. International journal of molecular sciences, 24(4), 3399. doi:10.3390/ijms24043399
A review of online learning strategies for biological NMR techniques a survey of educators
2022
Determining predictive metabolomic biomarkers of meniscal injury in dogs with cranial cruciate ligament disease
Platelet response to aspirin in UK and Irish pregnancy cohorts: a genome-wide approach
Mone, F., Gupta, J. K., Phelan, M. M., Meher, S., Lian, L. Y., Francis, B., . . . Navaratnam, K. (2022). Platelet response to aspirin in UK and Irish pregnancy cohorts: a genome-wide approach. PLATELETS, 33(6), 911-917. doi:10.1080/09537104.2021.2007872
<SUP>1</SUP>H NMR Metabolite Monitoring during the Differentiation of Human Induced Pluripotent Stem Cells Provides New Insights into the Molecular Events That Regulate Embryonic Chondrogenesis
Coope, A., Ghanameh, Z., Kingston, O., Sheridan, C. M., Barrett-Jolley, R., Phelan, M. M., & Oldershaw, R. A. (2022). <SUP>1</SUP>H NMR Metabolite Monitoring during the Differentiation of Human Induced Pluripotent Stem Cells Provides New Insights into the Molecular Events That Regulate Embryonic Chondrogenesis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(16). doi:10.3390/ijms23169266
Metabolic Profiling of Rheumatoid Arthritis Neutrophils Reveals Altered Energy Metabolism That Is Not Affected by JAK Inhibition
Chokesuwattanaskul, S., Alarcon, M. F., Mangalakumaran, S., Grosman, R., Cross, A. L., Chapman, E. A., . . . Wright, H. L. (2022). Metabolic Profiling of Rheumatoid Arthritis Neutrophils Reveals Altered Energy Metabolism That Is Not Affected by JAK Inhibition. METABOLITES, 12(7). doi:10.3390/metabo12070650
O-258 Nuclear magnetic resonance profiling of the vaginal metabolome in adverse early pregnancy outcomes
Hill, C., Phelan, M., Dutton, P., Busuulwa, P., Horne, A., Gemzell-Danielsson, K., . . . Hapangama, D. (2022). O-258 Nuclear magnetic resonance profiling of the vaginal metabolome in adverse early pregnancy outcomes. Human Reproduction, 37(Supplement_1). doi:10.1093/humrep/deac106.040
Differences in the metabolomic profile of canine stifle joint synovial fluid in dogs with cranial cruciate ligament rupture with or without meniscal injury
Pye, C., Phelan, M., Green, D., Comerford, E., & Peffers, M. (2022). Differences in the metabolomic profile of canine stifle joint synovial fluid in dogs with cranial cruciate ligament rupture with or without meniscal injury. In BSAVA Congress Proceedings 2022. British Small Animal Veterinary Association. doi:10.22233/9781913859114.32.2
Replicative ageing perturbs the metabolic signature of murine C<sub>2</sub>C<sub>12</sub> skeletal myotubes
Bipartite Collagen-Agarose Scaffolds to Model Eutopic Embryo Implantation
Hill, C. J., Aljassim, F., Phelan, M. M., Tempest, N., & Hapangama, D. K. (2022). Bipartite Collagen-Agarose Scaffolds to Model Eutopic Embryo Implantation. In REPRODUCTIVE SCIENCES Vol. 29 (pp. 185). Retrieved from https://www.webofscience.com/
Nuclear magnetic resonance profiling of the vaginal metabolome in adverse early pregnancy outcomes
Hill, C., Phelan, M., Dutton, P., Busuulwa, P., Horne, A., Gemzell-Danielsson, K., . . . Hapangama, D. (2022). Nuclear magnetic resonance profiling of the vaginal metabolome in adverse early pregnancy outcomes. In HUMAN REPRODUCTION Vol. 37 (pp. I152-I153). Retrieved from https://www.webofscience.com/
2021
Symptomatology and Serum Nuclear Magnetic Resonance Metabolomics; Do They Predict Endometriosis in Fertile Women Undergoing Laparoscopic Sterilisation? A Prospective Cross-sectional Study
Tempest, N., Hill, C. J., Whelan, A., De Silva, A., Drakeley, A. J., Phelan, M. M., & Hapangama, D. K. (2021). Symptomatology and Serum Nuclear Magnetic Resonance Metabolomics; Do They Predict Endometriosis in Fertile Women Undergoing Laparoscopic Sterilisation? A Prospective Cross-sectional Study. REPRODUCTIVE SCIENCES, 28(12), 3480-3490. doi:10.1007/s43032-021-00725-w
Metabolic profiling of maternal serum of women a high-risk of spontaneous preterm birth using NMR and MGWAS approach
Gupta, J. K., Care, A., Goodfellow, L., Alfirevic, Z., Lian, L. -Y., Mueller-Myhsok, B., . . . Phelan, M. M. (2021). Metabolic profiling of maternal serum of women a high-risk of spontaneous preterm birth using NMR and MGWAS approach. BIOSCIENCE REPORTS, 41(9). doi:10.1042/BSR20210759
"Fuel for the Damage Induced": Untargeted Metabolomics in Elite Rugby Union Match Play
Hudson, J. F., Phelan, M. M., Owens, D. J., Morton, J. P., Close, G. L., & Stewart, C. E. (2021). "Fuel for the Damage Induced": Untargeted Metabolomics in Elite Rugby Union Match Play. METABOLITES, 11(8). doi:10.3390/metabo11080544
Four Weeks of Probiotic Supplementation Alters the Metabolic Perturbations Induced by Marathon Running: Insight from Metabolomics
Pugh, J. N., Phelan, M. M., Caamano-Gutierrez, E., Sparks, S. A., Morton, J. P., Close, G. L., & Owens, D. J. (2021). Four Weeks of Probiotic Supplementation Alters the Metabolic Perturbations Induced by Marathon Running: Insight from Metabolomics. METABOLITES, 11(8). doi:10.3390/metabo11080535
O-234 Using serum metabolomics to identify biomarkers of viable early, intrauterine pregnancy: an untargeted 1H NMR-based approach
Hill, C., Phelan, M., Horne, A., Gemzell-Danielsson, K., Tempest, N., & Hapangama, D. (2021). O-234 Using serum metabolomics to identify biomarkers of viable early, intrauterine pregnancy: an untargeted 1H NMR-based approach. Human Reproduction, 36(Supplement_1). doi:10.1093/humrep/deab128.058
THE EFFECT OF JAK INHIBITION ON THE METABOLOME OF NEUTROPHILS FROM PATIENTS WITH RHEUMATOID ARTHRITIS
Alarcon, M. F., Grosman, R., Chokesuwattanaskul, S., Phelan, M., & Wright, H. L. (2021). THE EFFECT OF JAK INHIBITION ON THE METABOLOME OF NEUTROPHILS FROM PATIENTS WITH RHEUMATOID ARTHRITIS. In RHEUMATOLOGY Vol. 60. doi:10.1093/rheumatology/keab247.139
Assessing measures of aspirin adherence in pregnancy: Secondary analysis of the TEST randomized controlled trial
Mone, F., Mulcahy, C., Navaratnam, K., Phelan, M. M., Breathnach, F., Alfirevic, A., & McAuliffe, F. M. (2021). Assessing measures of aspirin adherence in pregnancy: Secondary analysis of the TEST randomized controlled trial. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 259, 222-223. doi:10.1016/j.ejogrb.2020.11.058
1H NMR Lipidomic Analysis of Canine Stifle Joint Synovial Fluid to Detect Biomarkers of Medial Meniscal Injury
Burke, C., Anderson, J. R., Clarke, E. J., Phelan, M. M., Comerford, E. J., & Peffers, M. J. (2021). 1H NMR Lipidomic Analysis of Canine Stifle Joint Synovial Fluid to Detect Biomarkers of Medial Meniscal Injury. British Small Animal Veterinary Association. doi:10.22233/9781913859039.19
Identification of early pregnancy metabolomic biomarkers of women at high-risk of preterm birth using NMR and mGWAS
Gupta, J., Care, A., Goodfellow, L., Alfirevic, Z., Lian, L. -Y., Muller-Myhsok, B., . . . Phelan, M. (2021). Identification of early pregnancy metabolomic biomarkers of women at high-risk of preterm birth using NMR and mGWAS. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 178 (pp. 432-433). Retrieved from https://www.webofscience.com/
Using Serum Metabolomics to Identify Biomarkers of Viable Early, Intrauterine Pregnancy: An Untargeted <SUP>1</SUP>H NMR-Based Approach.
Hill, C. J., Phelan, M., Horne, A., Gemzell-Danielsson, K., Tempest, N., & Hapangama, D. (2021). Using Serum Metabolomics to Identify Biomarkers of Viable Early, Intrauterine Pregnancy: An Untargeted <SUP>1</SUP>H NMR-Based Approach.. In REPRODUCTIVE SCIENCES Vol. 28 (pp. 297A). Retrieved from https://www.webofscience.com/
Using serum metabolomics to identify biomarkers of viable early, intrauterine pregnancy: an untargeted 1H NMR-based approach
Hill, C., Phelan, M., Horne, A., Gemzell-Danielsson, K., Tempest, N., & Hapangama, D. (2021). Using serum metabolomics to identify biomarkers of viable early, intrauterine pregnancy: an untargeted 1H NMR-based approach. In HUMAN REPRODUCTION Vol. 36 (pp. 134-135). Retrieved from https://www.webofscience.com/
2020
Title NMR-based metabolic profiling provides diagnostic and prognostic information in critically ill children with suspected infection
Grauslys, A., Phelan, M. M., Broughton, C., Baines, P. B., Jennings, R., Siner, S., . . . Carrol, E. D. (2020). Title NMR-based metabolic profiling provides diagnostic and prognostic information in critically ill children with suspected infection. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-77319-0
Ex-Vivo Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study.
Anderson, J. R., Phelan, M. M., Foddy, L., Clegg, P. D., & Peffers, M. J. (2020). Ex-Vivo Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study.. Journal of proteome research. doi:10.1021/acs.jproteome.0c00143
Optimization of Synovial Fluid Collection and Processing for NMR Metabolomics and LC-MS/MS Proteomics
Anderson, J. R., Phelan, M. M., Rubio-Martinez, L. M., Fitzgerald, M. M., Jones, S. W., Clegg, P. D., & Peffers, M. J. (2020). Optimization of Synovial Fluid Collection and Processing for NMR Metabolomics and LC-MS/MS Proteomics. Journal of Proteome Research, 19(7), 2585-2597. doi:10.1021/acs.jproteome.0c00035
Metabolomic analysis of synovial fluid from Thoroughbred racehorses diagnosed with palmar osteochondral disease using magnetic resonance imaging
Graham, R. J. T. Y., Anderson, J. R., Phelan, M. M., Cillan-Garcia, E., Bladon, B. M., & Taylor, S. E. (2020). Metabolomic analysis of synovial fluid from Thoroughbred racehorses diagnosed with palmar osteochondral disease using magnetic resonance imaging. EQUINE VETERINARY JOURNAL, 52(3), 384-390. doi:10.1111/evj.13199
<i>Ex-Vivo</i>Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study
Anderson, J., Phelan, M., Foddy, L., Clegg, P., & Peffers, M. (2020). <i>Ex-Vivo</i>Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study. doi:10.1101/2020.03.03.974501
Determining the True Background Rate of Endometriosis and if Diagnosis Preoperatively Can be Made, in a Low Risk Population, Utilising a Questionnaire.
Tempest, N., Whelan, A., Phelan, M., & Hapangama, D. (2020). Determining the True Background Rate of Endometriosis and if Diagnosis Preoperatively Can be Made, in a Low Risk Population, Utilising a Questionnaire.. In REPRODUCTIVE SCIENCES Vol. 27 (pp. 305A). Retrieved from https://www.webofscience.com/
Modelling embryo implantation in vitro using a three-dimensional co-culture system
Hill, C., Hapangama, D., & Phelan, M. (2020). Modelling embryo implantation in vitro using a three-dimensional co-culture system. In HUMAN REPRODUCTION Vol. 35 (pp. I300-I301). Retrieved from https://www.webofscience.com/
Using Nuclear Magnetic Resonance Metabolomics as a Noninvasive Way of Diagnosing Endometriosis.
Tempest, N., Whelan, A., Phelan, M., & Hapangama, D. (2020). Using Nuclear Magnetic Resonance Metabolomics as a Noninvasive Way of Diagnosing Endometriosis.. In REPRODUCTIVE SCIENCES Vol. 27 (pp. 303A-304A). Retrieved from https://www.webofscience.com/
2018
A robust intracellular metabolite extraction protocol for human neutrophil metabolic profiling
Chokesuwattanaskul, S., Phelan, M., Edwards, S., & Wright, H. L. (2018). A robust intracellular metabolite extraction protocol for human neutrophil metabolic profiling. PLoS One, 13(12). doi:10.1371/journal.pone.0209270
1H NMR metabolomics identifies underlying inflammatory pathology in osteoarthritis and rheumatoid arthritis synovial joints
Anderson, J., Chokesuwattanaskul, S., Phelan, M., Welting, T., Lian, L. Y., Peffers, M., & Wright, H. L. (2018). 1H NMR metabolomics identifies underlying inflammatory pathology in osteoarthritis and rheumatoid arthritis synovial joints. Journal of Proteome Research, 17(11), 3780-3790. doi:10.1021/acs.jproteome.8b00455
α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy
Wong, S. Q., Pontifex, M. G., Phelan, M. M., Pidathala, C., Kraemer, B. C., Barclay, J. W., . . . Morgan, A. (2018). α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy. Neurobiology of disease, 118, 40-54. doi:10.1016/j.nbd.2018.06.013
Effects of hypoxic preconditioning on neuroblastoma tumour oxygenation and metabolic signature in a chick embryo model
Al-Mutawa, Y. K., Herrmann, A., Corbishley, C., Losty, P. D., Phelan, M., & See, V. (2018). Effects of hypoxic preconditioning on neuroblastoma tumour oxygenation and metabolic signature in a chick embryo model. BIOSCIENCE REPORTS, 38. doi:10.1042/BSR20180185
Synovial Fluid Metabolites Differentiate between Septic and Nonseptic Joint Pathologies
Anderson, J. R., Phelan, M. M., Clegg, P. D., Peffers, M. J., & Rubio-Martinez, L. M. (2018). Synovial Fluid Metabolites Differentiate between Septic and Nonseptic Joint Pathologies. Journal of Proteome Research, 17(8), 2735-2743. doi:10.1021/acs.jproteome.8b00190
250 The effect of JAK inhibition on neutrophil killing, netosis and metabolism in rheumatoid arthritis
Chokesuwattanaskul, S., Mangalakumaran, S., Chapman, E., Cross, A., Phelan, M. M., Lian, L. -Y., . . . Wright, H. L. (2018). 250 The effect of JAK inhibition on neutrophil killing, netosis and metabolism in rheumatoid arthritis. Rheumatology, 57(suppl_3). doi:10.1093/rheumatology/key075.474
251 Synovial fluid metabolite profiles differ between osteoarthritis and rheumatoid arthritis
Anderson, J. R., Chokesuwattanaskul, S., Phelan, M. P., Welting, T. J. M., Lian, L. -Y., Peffers, M. J., & Wright, H. L. (2018). 251 Synovial fluid metabolite profiles differ between osteoarthritis and rheumatoid arthritis. Rheumatology, 57(suppl_3). doi:10.1093/rheumatology/key075.475
Evaluating assessments of aspirin adherence in low-risk women for pre-eclampsia prevention: A comparison of crude and objective measures
Mone, F., Phelan, M., Alfirevic, A., & McAuliffe, F. M. (2018). Evaluating assessments of aspirin adherence in low-risk women for pre-eclampsia prevention: A comparison of crude and objective measures. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 125 (pp. 66). Retrieved from https://www.webofscience.com/
SYNOVIAL FLUID METABOLITE PROFILES DIFFER BETWEEN OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS
Anderson, J. R., Chokesuwattanaskul, S., Phelan, M. P., Welting, T. J. M., Lian, L. -Y., Peffers, M. J., & Wright, H. L. (2018). SYNOVIAL FLUID METABOLITE PROFILES DIFFER BETWEEN OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS. In RHEUMATOLOGY Vol. 57. Retrieved from https://www.webofscience.com/
THE EFFECT OF JAK INHIBITION ON NEUTROPHIL KILLING, NETOSIS AND METABOLISM IN RHEUMATOID ARTHRITIS
Chokesuwattanaskul, S., Mangalakumaran, S., Chapman, E., Cross, A., Phelan, M. M., Lian, L. -Y., . . . Wright, H. L. (2018). THE EFFECT OF JAK INHIBITION ON NEUTROPHIL KILLING, NETOSIS AND METABOLISM IN RHEUMATOID ARTHRITIS. In RHEUMATOLOGY Vol. 57. Retrieved from https://www.webofscience.com/
2017
5. The influence of Rituximab on the metabolome of Juvenile-onset Systemic Lupus Erythematosus (JSLE) patients
Glaser, A., Wright, H. L., Midgley, A., Phelan, M. M., Peak, M., & Beresford, M. W. (2017). 5. The influence of Rituximab on the metabolome of Juvenile-onset Systemic Lupus Erythematosus (JSLE) patients. Rheumatology, 56(suppl_7). doi:10.1093/rheumatology/kex390.005
Using an NMR metabolomics approach to investigate the pathogenicity of amyloid-beta and alpha-synuclein
Phelan, M. M., Caamaño-Gutiérrez, E., Gant, M. S., Grosman, R. X., & Madine, J. (2017). Using an NMR metabolomics approach to investigate the pathogenicity of amyloid-beta and alpha-synuclein. Metabolomics, 13(12). doi:10.1007/s11306-017-1289-5
A novel MKRN3 nonsense mutation causing familial central precocious puberty.
Christoforidis, A., Skordis, N., Fanis, P., Dimitriadou, M., Sevastidou, M., Phelan, M. M., . . . Phylactou, L. A. (2017). A novel MKRN3 nonsense mutation causing familial central precocious puberty.. Endocrine, 56(2), 446-449. doi:10.1007/s12020-017-1232-6
242. METABOLIC ANALYSIS OF RHEUMATOID ARTHRITIS NEUTROPHILS: A NEW WAY TO MEASURE ACTIVATION OF CELLS IN DISEASE
Chokesuwattanaskul, S., Phelan, M. M., Moots, R. J., Edwards, S. W., & Wright, H. L. (2017). 242. METABOLIC ANALYSIS OF RHEUMATOID ARTHRITIS NEUTROPHILS: A NEW WAY TO MEASURE ACTIVATION OF CELLS IN DISEASE. Rheumatology, 56(suppl_2). doi:10.1093/rheumatology/kex062.244
Probing Medin Monomer Structure and its Amyloid Nucleation Using 13C-Direct Detection NMR in Combination with Structural Bioinformatics
Davies, H. A., Rigden, D. J., Phelan, M. M., & Madine, J. (2017). Probing Medin Monomer Structure and its Amyloid Nucleation Using 13C-Direct Detection NMR in Combination with Structural Bioinformatics. Scientific Reports, 7. doi:10.1038/srep45224
METABOLIC ANALYSIS OF RHEUMATOID ARTHRITIS NEUTROPHILS: A NEW WAY TO MEASURE ACTIVATION OF CELLS IN DISEASE
Chokesuwattanaskul, S., Phelan, M. M., Moots, R. J., Edwards, S. W., & Wright, H. L. (2017). METABOLIC ANALYSIS OF RHEUMATOID ARTHRITIS NEUTROPHILS: A NEW WAY TO MEASURE ACTIVATION OF CELLS IN DISEASE. In RHEUMATOLOGY Vol. 56 (pp. 146-147). Retrieved from https://www.webofscience.com/
THE INFLUENCE OF RITUXIMAB ON THE METABOLOME OF JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS (JSLE) PATIENTS
Glaser, A., Wright, H. L., Midgley, A., Phelan, M. M., Peak, M., & Beresford, M. W. (2017). THE INFLUENCE OF RITUXIMAB ON THE METABOLOME OF JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS (JSLE) PATIENTS. In RHEUMATOLOGY Vol. 56. Retrieved from https://www.webofscience.com/
2016
A novel MC4R deletion coexisting with FTO and MC1R gene variants, causes severe early onset obesity.
Neocleous, V., Shammas, C., Phelan, M. M., Fanis, P., Pantelidou, M., Skordis, N., . . . Toumba, M. (2016). A novel MC4R deletion coexisting with FTO and MC1R gene variants, causes severe early onset obesity.. Hormones (Athens, Greece), 15(3), 445-452. doi:10.14310/horm.2002.1686
<SUP>1</SUP>H, <SUP>15</SUP>N and <SUP>13</SUP>C assignment of the amyloidogenic protein medin using fast-pulsing NMR techniques
Davies, H. A., Phelan, M. M., & Madine, J. (2016). <SUP>1</SUP>H, <SUP>15</SUP>N and <SUP>13</SUP>C assignment of the amyloidogenic protein medin using fast-pulsing NMR techniques. BIOMOLECULAR NMR ASSIGNMENTS, 10(1), 75-77. doi:10.1007/s12104-015-9641-z
Genetic screening of non-classic CAH females with hyperandrogenemia identifies a novel CYP11B1 gene mutation.
Shammas, C., Byrou, S., Phelan, M. M., Toumba, M., Stylianou, C., Skordis, N., . . . Phylactou, L. A. (2016). Genetic screening of non-classic CAH females with hyperandrogenemia identifies a novel CYP11B1 gene mutation.. Hormones (Athens, Greece), 15(2), 235-242. doi:10.14310/horm.2002.1651
NMR Metabolomics: A Comparison of the Suitability of Various Commonly used National Health Service Blood Collection Tubes
Margaret Phelan, M., & Lian, L. -Y. (2016). NMR Metabolomics: A Comparison of the Suitability of Various Commonly used National Health Service Blood Collection Tubes. Current Metabolomics, 4(1), 78-81. doi:10.2174/2213235x03666151006220726
Microform Holoprosencephaly with Bilateral Congenital Elbow Dislocation; Increasing the Phenotypic Spectrum of Steinfeld Syndrome
Jones, G. E., Robertson, L., Maniyar, A., Shammas, C., Phelan, M. M., Vasudevan, P. C., & Tanteles, G. A. (2016). Microform Holoprosencephaly with Bilateral Congenital Elbow Dislocation; Increasing the Phenotypic Spectrum of Steinfeld Syndrome. AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 170(3), 754-759. doi:10.1002/ajmg.a.37511
In silico analysis of a novel MKRN3 missense mutation in familial central precocious puberty.
Neocleous, V., Shammas, C., Phelan, M. M., Nicolaou, S., Phylactou, L. A., & Skordis, N. (2016). In silico analysis of a novel MKRN3 missense mutation in familial central precocious puberty.. Clinical endocrinology, 84(1), 80-84. doi:10.1111/cen.12854
SCREENING FOR <i>MC4R</i> MUTATIONS IN CYPRIOT CHILDREN WITH SEVERE EARLY ONSET OBESITY AND TALL STATURE IDENTIFIED A NOVEL <i>MC4R</i> DELETION
Neocleous, V., Shammas, C., Phelan, M. M., Fanis, P., Pantelidou, M., Stylianou, C., . . . Toumba, M. (2016). SCREENING FOR <i>MC4R</i> MUTATIONS IN CYPRIOT CHILDREN WITH SEVERE EARLY ONSET OBESITY AND TALL STATURE IDENTIFIED A NOVEL <i>MC4R</i> DELETION. In ACTA PAEDIATRICA Vol. 106 (pp. 25). Retrieved from https://www.webofscience.com/
2015
Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial Amyloid
Davies, H., Phelan, M., Wilkinson, M., Migrino, R., Truran, S., Franco, D. A., . . . Madine, J. (2015). Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial Amyloid. Biophysical Journal, 109(11), 2363-2370. doi:10.1016/j.bpj.2015.10.034
Identification of Disease Specific Metabolic Fingerprints in Early Osteoarthritis
Peffers, M., Riggs, C., Phelan, M., & Clegg, P. (2015). Identification of Disease Specific Metabolic Fingerprints in Early Osteoarthritis. Equine Veterinary Journal, 47(S48), 13. doi:10.1111/evj.12486_28
2014
The structure, stability and pheromone binding of the male mouse protein sex pheromone darcin
Phelan, M. M., McLean, L., Armstrong, S. D., Hurst, J. L., Beynon, R. J., & Lian, L. -Y. (2014). The structure, stability and pheromone binding of the male mouse protein sex pheromone darcin. PLoS One, 9(10). doi:10.1371/journal.pone.0108415
Comparative study of the molecular variation between 'central' and 'peripheral' MUPs and significance for behavioural signalling
Phelan, M. M., McLean, L., Hurst, J. L., Beynon, R. J., & Lian, L. -Y. (2014). Comparative study of the molecular variation between 'central' and 'peripheral' MUPs and significance for behavioural signalling. BIOCHEMICAL SOCIETY TRANSACTIONS, 42, 866-872. doi:10.1042/BST20140082
The major urinary protein system in the rat
Gomez-Baena, G., Armstrong, S. D., Phelan, M. M., Hurst, J. L., & Beynon, R. J. (2014). The major urinary protein system in the rat. BIOCHEMICAL SOCIETY TRANSACTIONS, 42, 886-892. doi:10.1042/BST20140083
NMR elucidation of the role of Mg2+ in the structure and stability of the conserved RNA motifs of the EMCV IRES element.
Mohammed, S., Phelan, M. M., Rasul, U., & Ramesh, V. (2014). NMR elucidation of the role of Mg2+ in the structure and stability of the conserved RNA motifs of the EMCV IRES element.. Organic & biomolecular chemistry, 12(9), 1495-1509. doi:10.1039/c3ob41840e
2013
A report of 2 new cases of MODY2 and review of the literature: implications in the search for type 2 diabetes drugs.
Shammas, C., Neocleous, V., Phelan, M. M., Lian, L. -Y., Skordis, N., & Phylactou, L. A. (2013). A report of 2 new cases of MODY2 and review of the literature: implications in the search for type 2 diabetes drugs.. Metabolism: clinical and experimental, 62(11), 1535-1542. doi:10.1016/j.metabol.2013.06.007
¹H, ¹³C and ¹⁵N resonance assignments of the complement control protein modules of the complement component C7.
Clark, C., Thai, C. -T., Phelan, M. M., Bella, J., Uhrín, D., Ogata, R. T., . . . Bramham, J. (2013). ¹H, ¹³C and ¹⁵N resonance assignments of the complement control protein modules of the complement component C7.. Biomolecular NMR assignments, 7(2), 285-288. doi:10.1007/s12104-012-9429-3
Cooperative Catalysis through Noncovalent Interactions
Tang, W., Johnston, S., Iggo, J. A., Berry, N. G., Phelan, M., Lian, L., . . . Xiao, J. (2013). Cooperative Catalysis through Noncovalent Interactions. Angewandte Chemie, 125(6), 1712-1716. doi:10.1002/ange.201208774
Cooperative Catalysis through Noncovalent Interactions
Tang, W., Johnston, S., Iggo, J. A., Berry, N. G., Phelan, M., Lian, L., . . . Xiao, J. (2013). Cooperative Catalysis through Noncovalent Interactions. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(6), 1668-1672. doi:10.1002/anie.201208774
2012
Structure and assembly of a trans-periplasmic channel for type IV pili in Neisseria meningitidis.
Berry, J. -L., Phelan, M. M., Collins, R. F., Adomavicius, T., Tønjum, T., Frye, S. A., . . . Derrick, J. P. (2012). Structure and assembly of a trans-periplasmic channel for type IV pili in Neisseria meningitidis.. PLoS pathogens, 8(9), e1002923. doi:10.1371/journal.ppat.1002923
NMR Structure of Hsp12, a Protein Induced by and Required for Dietary Restriction-Induced Lifespan Extension in Yeast
Herbert, A. P., Riesen, M., Bloxam, L., Kosmidou, E., Wareing, B. M., Johnson, J. R., . . . Morgan, A. (2012). NMR Structure of Hsp12, a Protein Induced by and Required for Dietary Restriction-Induced Lifespan Extension in Yeast. PLOS ONE, 7(7). doi:10.1371/journal.pone.0041975
Evidence for metabolic cleavage of a PEGylated protein in vivo using multiple analytical methodologies.
Elliott, V. L., Edge, G. T., Phelan, M. M., Lian, L. -Y., Webster, R., Finn, R. F., . . . Kitteringham, N. R. (2012). Evidence for metabolic cleavage of a PEGylated protein in vivo using multiple analytical methodologies.. Molecular pharmaceutics, 9(5), 1291-1301. doi:10.1021/mp200587m
The structure and selectivity of the SR protein SRSF2 RRM domain with RNA.
Phelan, M. M., Goult, B. T., Clayton, J. C., Hautbergue, G. M., Wilson, S. A., & Lian, L. -Y. (2012). The structure and selectivity of the SR protein SRSF2 RRM domain with RNA.. Nucleic acids research, 40(7), 3232-3244. doi:10.1093/nar/gkr1164
Conformational characterization of synapse-associated protein 97 by nuclear magnetic resonance and small-angle X-ray scattering shows compact and elongated forms.
Tully, M. D., Grossmann, J. G., Phelan, M., Pandelaneni, S., Leyland, M., & Lian, L. -Y. (2012). Conformational characterization of synapse-associated protein 97 by nuclear magnetic resonance and small-angle X-ray scattering shows compact and elongated forms.. Biochemistry, 51(4), 899-908. doi:10.1021/bi201178v
2011
Analytical methodologies for determining the metabolism and disposition of PEGylated biopharmaceuticals
Edge, G. T., Elliott, V. L., Kitteringham, N. R., Phelan, M., Lian, L. -Y., Webster, R., & Park, B. K. (2011). Analytical methodologies for determining the metabolism and disposition of PEGylated biopharmaceuticals. Toxicology, 290(2-3), 137-138. doi:10.1016/j.tox.2011.09.064
The (1)H, (13)C and (15)N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing
Clayton, J. C., Phelan, M., Goult, B. T., Hautbergue, G. M., Wilson, S. A., & Lian, L. Y. (2011). The (1)H, (13)C and (15)N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing. BIOMOLECULAR NMR ASSIGNMENTS, 5, 7-10.
The 1H, 13C and 15N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing.
Clayton, J. C., Phelan, M., Goult, B. T., Hautbergue, G. M., Wilson, S. A., & Lian, L. -Y. (2011). The 1H, 13C and 15N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing.. Biomolecular NMR assignments, 5(1), 7-10. doi:10.1007/s12104-010-9254-5
The structure and selectivity of the SR protein SRSF2 RRM domain with RNA.
Phelan, M. M., Goult, B. T., Clayton, J. C., Hautbergue, G. M., Wilson, S. A., & Lian, L. Y. (2011). The structure and selectivity of the SR protein SRSF2 RRM domain with RNA.. Nucleic Acids Research.
2010
<SUP>1</SUP>H, <SUP>15</SUP>N and <SUP>13</SUP>C resonance assignment of darcin, a mouse major urinary protein
Phelan, M. M., McLean, L., Simpson, D. M., Hurst, J. L., Beynon, R. J., & Lian, L. -Y. (2010). <SUP>1</SUP>H, <SUP>15</SUP>N and <SUP>13</SUP>C resonance assignment of darcin, a mouse major urinary protein. BIOMOLECULAR NMR ASSIGNMENTS, 4(2), 239-241. doi:10.1007/s12104-010-9253-6
1H, 15N and 13C resonance assignment of darcin, a mouse major urinary protein.
Phelan, M. M., McLean, L., Simpson, D. M., Hurst, J. L., Beynon, R. J., & Lian, L. -Y. (2010). 1H, 15N and 13C resonance assignment of darcin, a mouse major urinary protein.. Biomolecular NMR assignments, 4(2), 239-241. doi:10.1007/s12104-010-9253-6
Building up a picture of C7 on the basis of high-resolution structure of its component modules
Clark, C., Phelan, M., Ford, S., Ogata, R., Bramham, J., & Barlow, P. N. (2010). Building up a picture of C7 on the basis of high-resolution structure of its component modules. Molecular Immunology, 47(13), 2261. doi:10.1016/j.molimm.2010.05.191
Characterisation of the dynamics and interactions of detergent micelles and the Neisseria meningitidis outer membrane protein OpcA
Phelan, M., Caldwell, Z., Derrick, J., & Lian, L. -Y. (2010). Characterisation of the dynamics and interactions of detergent micelles and the Neisseria meningitidis outer membrane protein OpcA. In XXIVth International Conference on Magnetic Resonance in Biological Systems (pp. 308). Cairns: International Conference on Magnetic Resonance in Biological Systems Committee.
2009
Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement.
Phelan, M. M., Thai, C. -T., Soares, D. C., Ogata, R. T., Barlow, P. N., & Bramham, J. (2009). Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement.. The Journal of biological chemistry, 284(29), 19637-19649. doi:10.1074/jbc.m901993200
1H, 15N and 13C resonance assignment of the pair of Factor-I like modules of the complement protein C7.
Phelan, M. M., Thai, C. -T., Herbert, A. P., Bella, J., Uhrín, D., Ogata, R. T., . . . Bramham, J. (2009). 1H, 15N and 13C resonance assignment of the pair of Factor-I like modules of the complement protein C7.. Biomolecular NMR assignments, 3(1), 49-52. doi:10.1007/s12104-008-9139-z
2008
A novel combination of chemical cross-linking, mass spectrometry and NMR reveals the architecture of complement component C7
Clark, C., Phelan, M., Chen, Z., Rappsilber, J., Ogata, R., Bramham, J., & Barlow, P. (2008). A novel combination of chemical cross-linking, mass spectrometry and NMR reveals the architecture of complement component C7. Molecular Immunology, 45(16), 4121. doi:10.1016/j.molimm.2008.08.076
The 3D structure of factor I-like modules from C7 provides structural and functional insights into assembly of the MAC
Phelan, M., Ogata, R., Barlow, P., & Bramham, J. (2008). The 3D structure of factor I-like modules from C7 provides structural and functional insights into assembly of the MAC. Molecular Immunology, 45(16), 4097. doi:10.1016/j.molimm.2008.08.007
The 3D structure of factor I-like modules from C7 provides structural and functional insights into assembly of the MAC
Phelan, M., Ogata, R., Barlow, P., & Bramham, J. (2008). The 3D structure of factor I-like modules from C7 provides structural and functional insights into assembly of the MAC. Molecular Immunology, 45(16), 4121.
2007
Structural investigation of C terminal region of C7
Phelan, M. M., & Bramham, J. (2007). Structural investigation of C terminal region of C7. Molecular Immunology, 44(16), 3987. doi:10.1016/j.molimm.2007.06.203
) Structural investigation of C terminal region of C7, 11th European Meeting on Complement in Human Disease
Phelan, M. M., & Bramham, J. (2007). ) Structural investigation of C terminal region of C7, 11th European Meeting on Complement in Human Disease. Molecular Immunology, 44(16), 3987.
2004
NMR studies of the structure and Mg2+ binding properties of a conserved RNA motif of EMCV picornavirus IRES element.
Phelan, M., Banks, R. J., Conn, G., & Ramesh, V. (2004). NMR studies of the structure and Mg2+ binding properties of a conserved RNA motif of EMCV picornavirus IRES element.. Nucleic acids research, 32(16), 4715-4724. doi:10.1093/nar/gkh805