Publications
Selected publications
- Blood CXCR3(+) CD4 T Cells Are Enriched in Inducible Replication Competent HIV in Aviremic Antiretroviral Therapy-Treated Individuals (Journal article - 2018)
- CD25(+) FoxP3(+) Memory CD4 T Cells Are Frequent Targets of HIV Infection In Vivo (Journal article - 2016)
- Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa (Journal article - 2015)
- Characterisation of Transmitted and Non-transmitted HIV in Index-recipient Transmission Pairs (Conference Paper - 2014)
- Envelope-Specific Epitope Recognition Patterns of HIV Vaccine-Induced IgG Antibodies Are Linked to Immunogen Structure and Sequence (Journal article - 2019)
2024
SARS-CoV-2 S, M and E Structural Proteins Down-modulate HIV-1 LTR Activity and Modulate Endoplasmic Reticulum Stress Responses
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods.
Mesinovic, M., Wong, X. C., Rajahram, G. S., Citarella, B. W., Peariasamy, K. M., van Someren Greve, F., . . . ISARIC Characterisation Group. (2024). At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods.. Scientific reports, 14(1), 16387. doi:10.1038/s41598-024-63212-7
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease.
Liew, F., Efstathiou, C., Fontanella, S., Richardson, M., Saunders, R., Swieboda, D., . . . ISARIC investigators. (2024). Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease.. Nature immunology, 25(4), 607-621. doi:10.1038/s41590-024-01778-0
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2024). Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 15(1), 2918. doi:10.1038/s41467-024-47320-6
Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study.
Cho, S. -M., Premraj, L., Battaglini, D., Fanning, J. P., Suen, J., Bassi, G. L., . . . ISARIC Clinical Characterization Group. (2024). Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study.. Brain communications, 6(2), fcae036. doi:10.1093/braincomms/fcae036
Development of a pseudo-typed virus particle based method to determine the efficacy of virucidal agents.
Thomas, J., Mughal, F., Roper, K. J., Kotsiri, A., Albalawi, W., Alshehri, A., . . . Hoptroff, M. (2024). Development of a pseudo-typed virus particle based method to determine the efficacy of virucidal agents.. Scientific reports, 14(1), 2174. doi:10.1038/s41598-024-52177-2
2023
The ecology of viruses in urban rodents with a focus on SARS-CoV-2
Fisher, A. M., Airey, G., Liu, Y., Gemmell, M., Thomas, J., Bentley, E. G., . . . Viney, M. (2023). The ecology of viruses in urban rodents with a focus on SARS-CoV-2. EMERGING MICROBES & INFECTIONS, 12(1). doi:10.1080/22221751.2023.2217940
Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19.
Sidhu, J. K., Siggins, M. K., Liew, F., Russell, C. D., Uruchurtu, A. S. S., Davis, C., . . . ISARIC4C investigators. (2023). Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19.. The Journal of infectious diseases, jiad590. doi:10.1093/infdis/jiad590
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2023). Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 14(1), 8487. doi:10.1038/s41467-023-42320-4
41 Generation of a SARS-CoV-2 pseudotyped viral particle system enabling for the study of cell-types of infection and patient sera neutralisation
Alshehri, A., Paxton, B., Pollakis, G., Thomas, J., Roper, K., & Albalawi, W. (2023). 41 Generation of a SARS-CoV-2 pseudotyped viral particle system enabling for the study of cell-types of infection and patient sera neutralisation. Clinical Infection in Practice, 20, 100301. doi:10.1016/j.clinpr.2023.100301
A multi-country analysis of COVID-19 hospitalizations by vaccination status.
Gonçalves, B. P., Jassat, W., Baruch, J., Hashmi, M., Rojek, A., Dasgupta, A., . . . ISARIC Clinical Characterisation Group. (2023). A multi-country analysis of COVID-19 hospitalizations by vaccination status.. Med (New York, N.Y.), 4(11), 797-812.e2. doi:10.1016/j.medj.2023.08.005
International Pediatric COVID-19 Severity Over the Course of the Pandemic
Zhu, Y., Almeida, F. J., Baillie, J. K., Bowen, A. C., Britton, P. N., Brizuela, M. E., . . . Short, K. R. (2023). International Pediatric COVID-19 Severity Over the Course of the Pandemic. JAMA PEDIATRICS. doi:10.1001/jamapediatrics.2023.3117
Liver injury in hospitalized patients with COVID-19: An International observational cohort study.
Tirupakuzhi Vijayaraghavan, B. K., Bishnu, S., Baruch, J., Citarella, B. W., Kartsonaki, C., Meeyai, A., . . . ISARIC Clinical Characterisation Group. (2023). Liver injury in hospitalized patients with COVID-19: An International observational cohort study.. PloS one, 18(9), e0277859. doi:10.1371/journal.pone.0277859
Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera.
Roper, K. J., Thomas, J., Albalawi, W., Maddocks, E., Dobson, S., Alshehri, A., . . . Pollakis, G. (2023). Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera.. Scientific reports, 13(1), 15014. doi:10.1038/s41598-023-41928-2
A second update on mapping the human genetic architecture of COVID-19.
COVID-19 Host Genetics Initiative. (2023). A second update on mapping the human genetic architecture of COVID-19.. Nature, 621(7977), E7-E26. doi:10.1038/s41586-023-06355-3
Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19
Wainstein, M., Spyrison, N., Dai, D., Ghadimi, M., Chávez-Iñiguez, J. S., Rizo-Topete, L., . . . Zucman, D. (2023). Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19. Kidney International Reports, 8(8), 1514-1530. doi:10.1016/j.ekir.2023.05.015
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (vol 617, pg 764, 2023)
Pairo-Castineira, E., Rawlik, K., Bretherick, A. D., Qi, T., Wu, Y., Nassiri, I., . . . Baillie, J. K. (2023). GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (vol 617, pg 764, 2023). NATURE. doi:10.1038/s41586-023-06383-z
Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
Griffee, M. J., Bozza, P. T., Reyes, L. F., Eddington, D. P., Rosenberger, D., Merson, L., . . . Zucman, D. (2023). Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry. Research and Practice in Thrombosis and Haemostasis, 7(5), 102142. doi:10.1016/j.rpth.2023.102142
Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversion
Eser, T. M., Baranov, O., Huth, M., Ahmed, M. I. M., Deak, F., Held, K., . . . Geldmacher, C. (2023). Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversion. NATURE COMMUNICATIONS, 14(1). doi:10.1038/s41467-023-38020-8
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
Pairo-Castineira, E., Rawlik, K., Bretherick, A. D., Qi, T., Wu, Y., Nassiri, I., . . . Baillie, J. K. (2023). GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. NATURE, 617(7962), 764-+. doi:10.1038/s41586-023-06034-3
Neurological manifestations of COVID-19 in adults and children.
Cho, S. -M., White, N., Premraj, L., Battaglini, D., Fanning, J., Suen, J., . . . ISARIC Clinical Characterisation Group. (2023). Neurological manifestations of COVID-19 in adults and children.. Brain : a journal of neurology, 146(4), 1648-1661. doi:10.1093/brain/awac332
Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID-19 cohort.
Shah, N., Xue, B., Xu, Z., Yang, H., Marwali, E., Dalton, H., . . . ISARIC Clinical Characterisation Group. (2023). Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID-19 cohort.. Artificial organs. doi:10.1111/aor.14542
The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.
Goldswain, H., Dong, X., Penrice-Randal, R., Alruwaili, M., Shawli, G. T., Prince, T., . . . Hiscox, J. A. (2023). The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.. Genome biology, 24(1), 47. doi:10.1186/s13059-023-02881-5
A Quantitative Method for the Study of HIV-1 and Mycobacterium tuberculosis Coinfection
Donnellan, S., Pennington, S. H., Ruggiero, A., Martinez-Rodriguez, C., Pouget, M., Thomas, J., . . . Paxton, W. A. (2023). A Quantitative Method for the Study of HIV-1 and Mycobacterium tuberculosis Coinfection. JOURNAL OF INFECTIOUS DISEASES, 227(5), 708-713. doi:10.1093/infdis/jiac491
Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19.
Kartsonaki, C., Baillie, J. K., Barrio, N. G., Baruch, J., Beane, A., Blumberg, L., . . . ISARIC Clinical Characterisation Group. (2023). Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19.. International journal of epidemiology, dyad012. doi:10.1093/ije/dyad012
Systematic comparison of HIV-1 Envelope-specific IgG responses induced by different vaccination regimens: Can we steer IgG recognition towards regions of viral vulnerability?
Horvath, A., Rogers, L., Pollakis, G., Baranov, O., Pieroth, N., Joseph, S., . . . Held, K. (2023). Systematic comparison of HIV-1 Envelope-specific IgG responses induced by different vaccination regimens: Can we steer IgG recognition towards regions of viral vulnerability?. Frontiers in immunology, 13, 1075606. doi:10.3389/fimmu.2022.1075606
Glycan dependent phenotype differences of HIV-1 generated from macrophage versus CD4+ T helper cell populations
Heeregrave, E. J., Thomas, J., van Capel, T. M., de Jong, E. C., Pollakis, G., & Paxton, W. A. (n.d.). Glycan dependent phenotype differences of HIV-1 generated from macrophage versus CD4+ T helper cell populations. Frontiers in Immunology, 14. doi:10.3389/fimmu.2023.1107349
SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study
Parker, E., Thomas, J., Roper, K. J., Ijaz, S., Edwards, T., Marchesin, F., . . . Pollakis, G. (2023). SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study. FRONTIERS IN IMMUNOLOGY, 14. doi:10.3389/fimmu.2023.1146702
SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination
Liew, F., Talwar, S., Cross, A., Willett, B. J., Scott, S., Logan, N., . . . Openshaw, P. J. M. (2023). SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. EBIOMEDICINE, 87. doi:10.1016/j.ebiom.2022.104402
2022
Early nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways and reduced systemic inflammation before seroconversion
Symptom-based case definitions for COVID-19: Time and geographical variations for detection at hospital admission among 260,000 patients.
Baruch, J., Rojek, A., Kartsonaki, C., Vijayaraghavan, B. K. T., Gonçalves, B. P., Pritchard, M. G., . . . ISARIC Clinical Characterisation Group. (2022). Symptom-based case definitions for COVID-19: Time and geographical variations for detection at hospital admission among 260,000 patients.. Influenza and other respiratory viruses, 16(6), 1040-1050. doi:10.1111/irv.13039
Paediatric COVID-19 mortality: a database analysis of the impact of health resource disparity
Marwali, E. M., Kekalih, A., Yuliarto, S., Wati, D. K., Rayhan, M., Valerie, I. C., . . . Dalton, H. J. (2022). Paediatric COVID-19 mortality: a database analysis of the impact of health resource disparity. BMJ PAEDIATRICS OPEN, 6(1). doi:10.1136/bmjpo-2022-001657
Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study
Vink, E., Davis, C., MacLean, A., Pascall, D., McDonald, S. E., Gunson, R., . . . Ho, A. (2022). Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. OPEN FORUM INFECTIOUS DISEASES, 9(11). doi:10.1093/ofid/ofac531
An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients
Goncalves, B. P., Hall, M., Jassat, W., Balan, V., Murthy, S., Kartsonaki, C., . . . Olliaro, P. L. (2022). An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients. ELIFE, 11. doi:10.7554/eLife.80556
Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.
Siggins, M. K., Davies, K., Fellows, R., Thwaites, R. S., Baillie, J. K., Semple, M. G., . . . ISARIC4C Investigators. (2022). Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.. Immunology. doi:10.1111/imm.13585
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
Reyes, L. F., Murthy, S., Garcia-Gallo, E., Merson, L., Ibanez-Prada, E. D., Rello, J., . . . Olliaro, P. L. (2022). Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. CRITICAL CARE, 26(1). doi:10.1186/s13054-022-04155-1
Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number
Keeling, M. J., Dyson, L., Guyver-Fletcher, G., Holmes, A., Semple, M. G., Tildesley, M. J., & Hill, E. M. (2022). Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number. STATISTICAL METHODS IN MEDICAL RESEARCH, 31(9), 1716-1737. doi:10.1177/09622802211070257
Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients
Ijaz, S., Dicks, S., Jegatheesan, K., Parker, E., Katsanovskaja, K., Vink, E., . . . Tedder, R. S. (2022). Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients. JOURNAL OF INFECTION, 85(2), 152-160. doi:10.1016/j.jinf.2022.05.033
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19
Garcia-Gallo, E., Merson, L., Kennon, K., Kelly, S., Citarella, B. W., Fryer, D. V., . . . Reyes, L. F. (2022). ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19. SCIENTIFIC DATA, 9(1). doi:10.1038/s41597-022-01534-9
Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19
Norris, T., Razieh, C., Zaccardi, F., Yates, T., Islam, N., Gillies, C. L., . . . Khunti, K. (2022). Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19. HEART, 108(15), 1200-1208. doi:10.1136/heartjnl-2021-320047
Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission
Relph, K. A., Russell, C. D., Fairfield, C. J., Turtle, L., de Silva, T. I., Siggins, M. K., . . . Young, P. (2022). Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission. Open Forum Infectious Diseases, 9(5). doi:10.1093/ofid/ofac179
Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study
Millar, J. E., Neyton, L., Seth, S., Dunning, J., Merson, L., Murthy, S., . . . Baillie, J. K. (2022). Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-08032-3
Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study
Narhi, F., Moonesinghe, S. R., Shenkin, S. D., Drake, T. M., Mulholland, R. H., Donegan, C., . . . Docherty, A. B. (2022). Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. LANCET DIGITAL HEALTH, 4(4). Retrieved from https://www.webofscience.com/
The HCV Envelope Glycoprotein Down-Modulates NF-κB Signalling and Associates With Stimulation of the Host Endoplasmic Reticulum Stress Pathway
McKay, L. G. A., Thomas, J., Albalawi, W., Fattaccioli, A., Dieu, M., Ruggiero, A., . . . Paxton, W. A. (2022). The HCV Envelope Glycoprotein Down-Modulates NF-κB Signalling and Associates With Stimulation of the Host Endoplasmic Reticulum Stress Pathway. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.831695
Diagnostic Accuracy of Dried Plasma Spot Specimens for HIV-1 Viral Load Testing: A Systematic Review and Meta-analysis
Fong, Y., Markby, J., Andreotti, M., Beck, I., Bourlet, T., Brambilla, D., . . . Vojnov, L. (2022). Diagnostic Accuracy of Dried Plasma Spot Specimens for HIV-1 Viral Load Testing: A Systematic Review and Meta-analysis. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 89(3), 261-273. doi:10.1097/QAI.0000000000002855
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (2022). SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. Cell, 185(3), 467-484.e15. doi:10.1016/j.cell.2021.12.046
Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study
Sullivan, M. K., Lees, J. S., Drake, T. M., Docherty, A. B., Oates, G., Hardwick, H. E., . . . Mark, P. B. (2022). Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study. NEPHROLOGY DIALYSIS TRANSPLANTATION, 37(2), 271-284. doi:10.1093/ndt/gfab303
Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol
Knight, S. R., Gupta, R. K., Ho, A., Pius, R., Buchan, I., Carson, G., . . . Harrison, E. M. (2022). Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. THORAX, 77(6), 606-615. doi:10.1136/thoraxjnl-2021-217629
2021
Mapping the human genetic architecture of COVID-19
Niemi, M. E. K., Karjalainen, J., Daly, M., Ganna, A., Mehtonen, J., Cordioli, M., . . . Dopazo, X. (2021). Mapping the human genetic architecture of COVID-19. NATURE, 600(7889), 472-+. doi:10.1038/s41586-021-03767-x
Measuring Proviral HIV-1 DNA: Hurdles and Improvements to an Assay Monitoring Integration Events Utilising Human <i>Alu</i> Repeat Sequences
Malatinkova, E., Thomas, J., De Spiegelaere, W., Rutsaert, S., Geretti, A. M., Pollakis, G., . . . Ruggiero, A. (2021). Measuring Proviral HIV-1 DNA: Hurdles and Improvements to an Assay Monitoring Integration Events Utilising Human <i>Alu</i> Repeat Sequences. LIFE-BASEL, 11(12). doi:10.3390/life11121410
The value of open-source clinical science in pandemic response: lessons from ISARIC
The value of open-source clinical science in pandemic response: lessons from ISARIC (2021). LANCET INFECTIOUS DISEASES, 21(12), 1623-1624. doi:10.1016/S1473-3099(21)00565-X
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells
de, S. T. I., Liu, G., Lindsey, B. B., Dong, D., Moore, S. C., Hsu, N. S., . . . Dong, T. (2021). The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. ISCIENCE, 24(11). doi:10.1016/j.isci.2021.103353
A prenylated dsRNA sensor protects against severe COVID-19
Wickenhagen, A., Sugrue, E., Lytras, S., Kuchi, S., Noerenberg, M., Turnbull, M. L., . . . Wilson, S. J. (2021). A prenylated dsRNA sensor protects against severe COVID-19. SCIENCE, 374(6567). doi:10.1126/science.abj3624
Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study
Hurst, E. A., Mellanby, R. J., Handel, I., Griffith, D. M., Rossi, A. G., Walsh, T. S., . . . Russell, C. D. (2021). Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study. BMJ OPEN, 11(10). doi:10.1136/bmjopen-2021-055435
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
Abdukahil, S. A., Abe, R., Abel, L., Absil, L., Acker, A., Adachi, S., . . . Zucman, D. (2021). COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study. INFECTION, 49(5), 889-905. doi:10.1007/s15010-021-01599-5
Streptolysin O concentration and activity is central to in vivo phenotype and disease outcome in Group A Streptococcus infection
Clarke, J., Baltazar, M., Alsahag, M., Panagiotou, S., Pouget, M., Paxton, W. A., . . . Kadioglu, A. (2021). Streptolysin O concentration and activity is central to in vivo phenotype and disease outcome in Group A Streptococcus infection. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-97866-4
Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study
Russell, C. D., Fairfield, C. J., Drake, T. M., Turtle, L., Seaton, R. A., Wootton, D. G., . . . Ho, A. (2021). Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. LANCET MICROBE, 2(8), E354-E365. doi:10.1016/S2666-5247(21)00090-2
Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study
Drake, T. M., Riad, A. M., Fairfield, C. J., Egan, C., Knight, S. R., Pius, R., . . . Semple, M. G. (2021). Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. LANCET, 398(10296), 223-237. Retrieved from https://www.webofscience.com/
Stepwise Conformational Stabilization of a HIV-1 Clade C Consensus Envelope Trimer Immunogen Impacts the Profile of Vaccine-Induced Antibody Responses
Hauser, A., Carnell, G., Held, K., Sulbaran, G., Tischbierek, N., Rogers, L., . . . Wagner, R. (2021). Stepwise Conformational Stabilization of a HIV-1 Clade C Consensus Envelope Trimer Immunogen Impacts the Profile of Vaccine-Induced Antibody Responses. VACCINES, 9(7). doi:10.3390/vaccines9070750
Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK
Docherty, A., Mulholland, R., Lone, N. I., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . Semple, M. (2021). Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 773-785. doi:10.1016/S2213-2600(21)00175-2
Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.
Drake, T. M., Fairfield, C. J., Pius, R., Knight, S. R., Norman, L., Girvan, M., . . . ISARIC4C Investigators. (2021). Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.. The Lancet. Rheumatology, 3(7), e498-e506. doi:10.1016/s2665-9913(21)00104-1
Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort
Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., . . . Khunti, K. (2021). Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort. OBESITY, 29(7), 1223-1230. doi:10.1002/oby.23178
Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK
Bloom, C. I., Drake, T. M., Docherty, A. B., Lipworth, B. J., Johnston, S. L., Nguyen-Van-Tam, J. S., . . . Openshaw, P. J. M. (2021). Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 699-711. doi:10.1016/S2213-2600(21)00013-8
Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England
Leclerc, Q. J., Fuller, N. M., Keogh, R. H., Diaz-Ordaz, K., Sekula, R., Semple, M. G., . . . Knight, G. M. (2021). Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England. BMC HEALTH SERVICES RESEARCH, 21(1). doi:10.1186/s12913-021-06509-x
Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study
Gupta, R. K., Harrison, E. M., Ho, A., Docherty, A. B., Knight, S. R., van Smeden, M., . . . Noursadeghi, M. (2021). Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(4), 349-359. doi:10.1016/S2213-2600(20)30559-2
Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.
Thwaites, R. S., Sanchez Sevilla Uruchurtu, A., Siggins, M. K., Liew, F., Russell, C. D., Moore, S. C., . . . ISARIC4C investigators. (2021). Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.. Science Immunology, 6(57). doi:10.1126/sciimmunol.abg9873
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity
Thomson, E. C., Rosen, L. E., Shepherd, J. G., Spreafico, R., Filipe, A. D. S., Wojcechowskyj, J. A., . . . Snell, G. (2021). Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. CELL, 184(5), 1171-+. doi:10.1016/j.cell.2021.01.037
Genetic mechanisms of critical illness in COVID-19
Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A. D., Rawlik, K., Pasko, D., . . . Baillie, J. K. (2021). Genetic mechanisms of critical illness in COVID-19. NATURE, 591(7848), 92-+. doi:10.1038/s41586-020-03065-y
Ebola virus antibody decay-stimulation in a high proportion of survivors
Adaken, C., Scott, J. T., Sharma, R., Gopal, R., Dicks, S., Niazi, S., . . . Pollakis, G. (2021). Ebola virus antibody decay-stimulation in a high proportion of survivors. NATURE, 590(7846), 468-+. doi:10.1038/s41586-020-03146-y
Generation of Liposomes to Study the Effect of <i>Mycobacterium Tuberculosis</i> Lipids on HIV-1 <i>cis</i>- and <i>trans</i>-Infections
Pouget, M., Coussens, A. K., Ruggiero, A., Koch, A., Thomas, J., Besra, G. S., . . . Paxton, W. A. (2021). Generation of Liposomes to Study the Effect of <i>Mycobacterium Tuberculosis</i> Lipids on HIV-1 <i>cis</i>- and <i>trans</i>-Infections. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(4). doi:10.3390/ijms22041945
2020
Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020
Thompson, C. P., Grayson, N. E., Paton, R. S., Bolton, J. S., Lourenco, J., Penman, B. S., . . . Simmonds, P. (2020). Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. EUROSURVEILLANCE, 25(42), 33-41. doi:10.2807/1560-7917.ES.2020.25.42.2000685
Human Leucocyte Antigen-G (HLA-G) 3’ UTR Genetic Polymorphisms associate with HIV-1 High-Risk Seronegative Status in the Amsterdam Cohorts Studies
Christmas, S. E. (2020). Human Leucocyte Antigen-G (HLA-G) 3’ UTR Genetic Polymorphisms associate with HIV-1 High-Risk Seronegative Status in the Amsterdam Cohorts Studies. JAID, 7(1). doi:10.17303/jaid.2020.7.104
Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.
Drake, T. M., Docherty, A. B., Harrison, E. M., Quint, J. K., Adamali, H., Agnew, S., . . . ISARIC4C Investigators. (2020). Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.. Am J Respir Crit Care Med. doi:10.1164/rccm.202007-2794OC
Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.
Knight, S. R., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T. M., . . . ISARIC4C investigators. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.. BMJ: British Medical Journal, 370. doi:10.1136/bmj.m3339
Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease
Dong, X., Munoz-Basagoiti, J., Rickett, N. Y., Pollakis, G., Paxton, W. A., Guenther, S., . . . Hiscox, J. A. (2020). Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease. GENOME BIOLOGY, 21(1). doi:10.1186/s13059-020-02148-3
Pseudotyping of VSV with Ebola virus glycoprotein is superior to HIV-1 for the assessment of neutralising antibodies
Steeds, K., Hall, Y., Slack, G. S., Longet, S., Strecker, T., Fehling, S. K., . . . Carroll, M. W. (2020). Pseudotyping of VSV with Ebola virus glycoprotein is superior to HIV-1 for the assessment of neutralising antibodies. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-71225-1
Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study
Swann, O., Holden, K., Turtle, L., Pollock, L., Fairfield, C., Drake, T., . . . ISARIC Coronavirus Clinical Characterisation Consortium (ISARIC4C) Investigators. (2020). Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study. BMJ, 370. doi:10.1136/bmj.m3249
Chloroquine Administration in Breastfeeding Mothers Associates with Increased HIV-1 Plasma Viral Loads
Paxton, W., Naarding, M., Wit, F. W. N. M., Veldhuijzen, N., Chersich, M., Kankindi, B., . . . Luchters, S. (2020). Chloroquine Administration in Breastfeeding Mothers Associates with Increased HIV-1 Plasma Viral Loads. doi:10.1101/2020.04.29.20085308
Induction of Identical IgG HIV-1 Envelope Epitope Recognition Patterns After Initial HIVIS-DNA/MVA-CMDR Immunization and a Late MVA-CMDR Boost
Joachim, A., Ahmed, M. I. M., Pollakis, G., Rogers, L., Hoffmann, V. S., Munseri, P., . . . Held, K. (2020). Induction of Identical IgG HIV-1 Envelope Epitope Recognition Patterns After Initial HIVIS-DNA/MVA-CMDR Immunization and a Late MVA-CMDR Boost. FRONTIERS IN IMMUNOLOGY, 11. doi:10.3389/fimmu.2020.00719
Measuring the Success of HIV-1 Cure Strategies
Thomas, J., Ruggiero, A., Paxton, W. A., & Pollakis, G. (2020). Measuring the Success of HIV-1 Cure Strategies. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 10. doi:10.3389/fcimb.2020.00134
2019
Bile-salt stimulated lipase polymorphisms do not associate with HCV susceptibility
Steba, G. S., Koekkoek, S. M., Prins, M., Brinkman, K., Kwa, D., van der Meer, J. T. M., . . . Acu, M. O. S. A. I. C. M. S. M. O. S. (2019). Bile-salt stimulated lipase polymorphisms do not associate with HCV susceptibility. VIRUS RESEARCH, 274. doi:10.1016/j.virusres.2019.197715
High Resolution Analysis of Respiratory Syncytial Virus Infection In Vivo
Aljabr, W., Armstrong, S., Rickett, N. Y., Pollakis, G., Touzelet, O., Cloutman-Green, E., . . . Hiscox, J. A. (2019). High Resolution Analysis of Respiratory Syncytial Virus Infection In Vivo. VIRUSES-BASEL, 11(10). doi:10.3390/v11100926
Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4+ T-lymphocyte responses and HIV-1 infection in vitro
Mouser, E., Pollakis, G., Smits, H., Thomas, J., Yazdanbakhsh, M., De Jong, E., & Paxton, W. (2019). Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4+ T-lymphocyte responses and HIV-1 infection in vitro. PLoS Pathogens, 15(9). doi:10.1371/journal.ppat.1007924
Streptolysin production and activity is central to<i>in vivo</i>pathotype and disease outcome in GAS infections
Clarke, J., Baltazar, M., Alsahag, M., Panagiotou, S., Pouget, M., Paxton, W., . . . Kadioglu, A. (2019). Streptolysin production and activity is central to<i>in vivo</i>pathotype and disease outcome in GAS infections. doi:10.1101/686303
SNP rs688 within the low-density lipoprotein receptor (LDL-R) gene associates with HCV susceptibility
Steba, G. S., Koekkoek, S. M., Tanck, M. W. T., Vanhommerig, J. W., van der Meer, J. T. M., Kwa, D., . . . MOSAIC (MSM observational Study of Acute infection with Hepatitis C) Study Group and the ACS (Amsterdam Cohort Studies). (2019). SNP rs688 within the low-density lipoprotein receptor (LDL-R) gene associates with HCV susceptibility. Liver International, 39(3), 463-469. doi:10.1111/liv.13978
Dendritic Cells Potently Purge Latent HIV-1 in TCR-Activated Cells via the PI3K-Akt-mTOR Pathway: Implications for ‘Shock and Kill’ Strategies and Reservoir Analysis
van Montfort, T., van der Sluis, R., Darcis, G., Beaty, D., Groen, K., Pasternak, A. O., . . . Berkhout, B. (2019). Dendritic Cells Potently Purge Latent HIV-1 in TCR-Activated Cells via the PI3K-Akt-mTOR Pathway: Implications for ‘Shock and Kill’ Strategies and Reservoir Analysis. EBioMedicine.
Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway
van Montfort, T., van der Sluis, R., Darcis, G., Beaty, D., Groen, K., Pasternak, A. O., . . . Berkhout, B. (2019). Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway. EBioMedicine. doi:10.1016/j.ebiom.2019.02.014
Comparative analysis and generation of a robust HIV-1 DNA quantification assay
Thomas, J., Ruggiero, A., Procopio, F., Pantaleo, G., Paxton, A. W., & Pollakis, G. (2019). Comparative analysis and generation of a robust HIV-1 DNA quantificationassay. Journal of Virological Methods, 263, 24-31. doi:10.1016/j.jviromet.2018.10.010
Envelope-Specific Epitope Recognition Patterns of HIV Vaccine-Induced IgG Antibodies Are Linked to Immunogen Structure and Sequence
Nadai, Y., Held, K., Joseph, S., Ahmed, M. I. M., Hoffmann, V. S., Peterhoff, D., . . . Geldmacher, C. (n.d.). Envelope-Specific Epitope Recognition Patterns of HIV Vaccine-Induced IgG Antibodies Are Linked to Immunogen Structure and Sequence. Frontiers in Immunology, 10. doi:10.3389/fimmu.2019.00717
2018
Development of a Sensitive qPCR Assay for Quantification of Integrated HIV-1 DNA in Peripheral Blood Mononuclear Cells
Ruggiero, A., Malatinkova, E., De Spiegelaere, W., Thomas, J., Rutsaert, S., Geretti, A. M., . . . Paxton, W. A. (n.d.). Development of a Sensitive qPCR Assay for Quantification of Integrated HIV-1 DNA in Peripheral Blood Mononuclear Cells. Journal of Virological Methods.
Detection, characterization, and enrollment of donors of Ebola convalescent plasma in Sierra Leone
Tedder, R. S., Samuel, D., Dicks, S., Scott, J. T., Ijaz, S., Smith, C. C., . . . Semple, M. G. (2018). Detection, characterization, and enrollment of donors of Ebola convalescent plasma in Sierra Leone. TRANSFUSION, 58(5), 1289-1298. doi:10.1111/trf.14580
Blood CXCR3(+) CD4 T Cells Are Enriched in Inducible Replication Competent HIV in Aviremic Antiretroviral Therapy-Treated Individuals
Banga, R., Procopio, F. A., Ruggiero, A., Noto, A., Ohmiti, K., Cavassini, M., . . . Perreau, M. (2018). Blood CXCR3(+) CD4 T Cells Are Enriched in Inducible Replication Competent HIV in Aviremic Antiretroviral Therapy-Treated Individuals. Frontiers in Immunology, 9. doi:10.3389/fimmu.2018.00144
HIV-1 Transmission: Influence of Bodily Secretions
Pollakis, G., & Paxton, W. A. (2018). HIV-1 Transmission: Influence of Bodily Secretions. In Encyclopedia of AIDS (pp. 920-928). Springer New York. doi:10.1007/978-1-4939-7101-5_136
2017
Virus genomes reveal factors that spread and sustained the Ebola epidemic
Dudas, G., Carvalho, L. M., Bedford, T., Tatem, A. J., Baele, G., Faria, N. R., . . . Rambaut, A. (2017). Virus genomes reveal factors that spread and sustained the Ebola epidemic. NATURE, 544(7650), 309-315. doi:10.1038/nature22040
2016
CD25(+) FoxP3(+) Memory CD4 T Cells Are Frequent Targets of HIV Infection In Vivo
Chachage, M., Pollakis, G., Kuffour, E. O., Haase, K., Bauer, A., Nadai, Y., . . . Geldmacher, C. (2016). CD25(+) FoxP3(+) Memory CD4 T Cells Are Frequent Targets of HIV Infection In Vivo. Journal of Virology, 90(20), 8954-8967. doi:10.1128/JVI.00612-16
PD-1+ and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals
Banga, R., Procopio, F. A., Noto, A., Pollakis, G., Cavassini, M., Ohmiti, K., . . . Perreau, M. (2016). PD-1+ and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals. Nature Medicine, 22(7), 754-761. doi:10.1038/nm.4113
Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach
Aljabr, W., Touzelet, O., Pollakis, G., Wu, W., Munday, D. C., Hughes, M., . . . Hiscox, J. A. (2016). Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach. JOURNAL OF VIROLOGY, 90(10), 4876-4888. doi:10.1128/JVI.02349-15
Real-time, portable genome sequencing for Ebola surveillance
Quick, J., Loman, N. J., Duraffour, S., Simpson, J. T., Severi, E., Cowley, L., . . . Carroll, M. W. (2016). Real-time, portable genome sequencing for Ebola surveillance. Nature, 530, 228-232. doi:10.1038/nature16996
Brugia malayi Antigen (BmA) Inhibits HIV-1 Trans-Infection but Neither BmA nor ES-62 Alter HIV-1 Infectivity of DC Induced CD4(+) Th-Cells
Mouser, E. E. I. M., Pollakis, G., Yazdanbakhsh, M., Harnett, W., de Jong, E. C., & Paxton, W. A. (2016). Brugia malayi Antigen (BmA) Inhibits HIV-1 Trans-Infection but Neither BmA nor ES-62 Alter HIV-1 Infectivity of DC Induced CD4(+) Th-Cells. PLOS ONE, 11(1). doi:10.1371/journal.pone.0146527
Env-specific IgG Responses Induced by Identical and None-identical Immunogen Prime-boost Vaccination Strategies Target Different Antigenic Regions
Nadai, Y., Ahmed, M. I. M., Joseph, S., Missanga, M., Bauer, A., Cope, A. V., . . . Held, K. (2016). Env-specific IgG Responses Induced by Identical and None-identical Immunogen Prime-boost Vaccination Strategies Target Different Antigenic Regions. In AIDS RESEARCH AND HUMAN RETROVIRUSES Vol. 32 (pp. 392). Retrieved from https://www.webofscience.com/
2015
During Stably Suppressive Antiretroviral Therapy Integrated HIV-1 DNA Load in Peripheral Blood is Associated with the Frequency of CD8 Cells Expressing HLA-DR/DP/DQ
Ruggiero, A., De Spiegelaere, W., Cozzi-Lepri, A., Kiselinova, M., Pollakis, G., Beloukas, A., . . . Geretti, A. M. (2015). During Stably Suppressive Antiretroviral Therapy Integrated HIV-1 DNA Load in Peripheral Blood is Associated with the Frequency of CD8 Cells Expressing HLA-DR/DP/DQ. EBIOMEDICINE, 2(9), 1153-1159. doi:10.1016/j.ebiom.2015.07.025
Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa
Carroll, M. W., Matthews, D. A., Hiscox, J., Elmore, M. J., Pollakis, G., Rambaut, A., . . . Günther, S. (2015). Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa. Nature, 524(7563), 97-101. doi:10.1038/nature14594
Association between gp120 envelope V1V2 and V4V5 variable loop profiles in a defined HIV-1 transmission cluster
Pollakis, G., Baan, E., van Werkhoven, M. B., Berkhout, B., Bakker, M., Jurriaans, S., & Paxton, W. A. (2015). Association between gp120 envelope V1V2 and V4V5 variable loop profiles in a defined HIV-1 transmission cluster. AIDS, 29(10), 1161-1171. doi:10.1097/QAD.0000000000000692
Colorectal Mucus Binds DC-SIGN and Inhibits HIV-1 <i>Trans</i>-Infection of CD4<SUP>+</SUP> T-Lymphocytes
Stax, M. J., Mouser, E. E. I. M., van Montfort, T., Sanders, R. W., de Vries, H. J. C., Dekker, H. L., . . . Paxton, W. A. (2015). Colorectal Mucus Binds DC-SIGN and Inhibits HIV-1 <i>Trans</i>-Infection of CD4<SUP>+</SUP> T-Lymphocytes. PLOS ONE, 10(3). doi:10.1371/journal.pone.0122020
Improved metastasis-free survival in nonadjuvantly treated postmenopausal breast cancer patients with chemokine receptor 5 del32 frameshift mutations
Span, P. N., Pollakis, G., Paxton, W. A., Sweep, F. C. G. J., Foekens, J. A., Martens, J. W. M., . . . van Laarhoven, H. W. M. (2015). Improved metastasis-free survival in nonadjuvantly treated postmenopausal breast cancer patients with chemokine receptor 5 del32 frameshift mutations. INTERNATIONAL JOURNAL OF CANCER, 136(1), 91-97. doi:10.1002/ijc.28962
The burden of integrated HIV-1 DNA during suppressive ART is associated with levels of activated (HLA-DR+) CD8 T cells
Ruggiero, A., King, S., Pollakis, G., Beloukas, A., Geretti, A. M., Vandekerckhove, L., . . . Phillips, A. (2015). The burden of integrated HIV-1 DNA during suppressive ART is associated with levels of activated (HLA-DR+) CD8 T cells. HIV MEDICINE, 16, 21. Retrieved from https://www.webofscience.com/
2014
Characterisation of Transmitted and Non-transmitted HIV in Index-recipient Transmission Pairs
Bracke, L., Willems, E., Gall, A., Kellam, P., Coppens, S., Meehan, C., . . . Ariën, K. (2014). Characterisation of Transmitted and Non-transmitted HIV in Index-recipient Transmission Pairs. AIDS Research and Human Retroviruses, 30(S1), A223-A224. doi:10.1089/aid.2014.5491.abstract
Increased HIV-1 Activity in Anal High-Grade Squamous Intraepithelial Lesions Compared With Unaffected Anal Mucosa in Men Who Have Sex With Men
Pollakis, G., Richel, O., Vis, J. D., Prins, J. M., Paxton, W. A., & de Vries, H. J. C. (2014). Increased HIV-1 Activity in Anal High-Grade Squamous Intraepithelial Lesions Compared With Unaffected Anal Mucosa in Men Who Have Sex With Men. CLINICAL INFECTIOUS DISEASES, 58(11), 1634-1637. doi:10.1093/cid/ciu133
Characterisation of Transmitted and Non-transmitted HIV in Index-recipient Transmission Pairs
Bracke, L., Willems, E., Gall, A., Kellam, P., Coppens, S., Meehan, C., . . . Arien, K. (2014). Characterisation of Transmitted and Non-transmitted HIV in Index-recipient Transmission Pairs. In AIDS RESEARCH AND HUMAN RETROVIRUSES Vol. 30 (pp. A224-A225). Retrieved from https://www.webofscience.com/
HIV-1 Transmission: Influence of Bodily Secretions
Pollakis, G., & Paxton, W. A. (2014). HIV-1 Transmission: Influence of Bodily Secretions. In Encyclopedia of AIDS (pp. 1-10). Springer New York. doi:10.1007/978-1-4614-9610-6_136-1
2013
Bile salt-stimulated lipase from human milk and mucosal transmission of pathogens during breastfeeding
Pollakis, G., Stax, M. J., & Paxton, W. A. (2013). Bile salt-stimulated lipase from human milk and mucosal transmission of pathogens during breastfeeding. In HANDBOOK OF DIETARY AND NUTRITIONAL ASPECTS OF HUMAN BREAST MILK (pp. 461-476). doi:10.3920/978-90-8686-764-6_26
HIV-1 Autologous Antibody Neutralization Associates with Mother to Child Transmission
Baan, E., de Ronde, A., Stax, M., Sanders, R. W., Luchters, S., Vyankandondera, J., . . . Paxton, W. A. (2013). HIV-1 Autologous Antibody Neutralization Associates with Mother to Child Transmission. PLOS ONE, 8(7). doi:10.1371/journal.pone.0069274
Dendritic Cell-induced Activation of Latent HIV-1 Provirus in Actively Proliferating Primary T Lymphocytes
van der Sluis, R. M., van Montfort, T., Pollakis, G., Sanders, R. W., Speijer, D., Berkhout, B., & Jeeninga, R. E. (2013). Dendritic Cell-induced Activation of Latent HIV-1 Provirus in Actively Proliferating Primary T Lymphocytes. PLOS PATHOGENS, 9(3). doi:10.1371/journal.ppat.1003259
Human immunodeficiency virus type 1 gp120 envelope characteristics associated with disease progression differ in family members infected with genetically similar viruses
Baan, E., van der Sluis, R. M., Bakker, M. E., Bekker, V., Pajkrt, D., Jurriaans, S., . . . Pollakis, G. (2013). Human immunodeficiency virus type 1 gp120 envelope characteristics associated with disease progression differ in family members infected with genetically similar viruses. JOURNAL OF GENERAL VIROLOGY, 94, 20-29. doi:10.1099/vir.0.046185-0
Quantitation of HIV-1 DNA with a sensitive TaqMan assay that has broad subtype specificity
van der Sluis, R. M., van Montfort, T., Centlivre, M., Schopman, N. C. T., Cornelissen, M., Sanders, R. W., . . . Pollakis, G. (2013). Quantitation of HIV-1 DNA with a sensitive TaqMan assay that has broad subtype specificity. JOURNAL OF VIROLOGICAL METHODS, 187(1), 94-102. doi:10.1016/j.jviromet.2012.09.019
2012
Selective packaging of cellular miRNAs in HIV-1 particles
Schopman, N. C. T., van Montfort, T., Willemsen, M., Knoepfel, S. A., Pollakis, G., van Kampen, A., . . . Berkhout, B. (2012). Selective packaging of cellular miRNAs in HIV-1 particles. VIRUS RESEARCH, 169(2), 438-447. doi:10.1016/j.virusres.2012.06.017
Use of (alternative) coreceptors for HIV entry
Pollakis, G., & Paxton, W. A. (2012). Use of (alternative) coreceptors for HIV entry. CURRENT OPINION IN HIV AND AIDS, 7(5), 440-449. doi:10.1097/COH.0b013e328356e9f3
HIV Type 1 Mother-to-Child Transmission Facilitated by Distinctive Glycosylation Sites in the gp120 Envelope Glycoprotein
Baan, E., de Ronde, A., Luchters, S., Vyankandondera, J., Lange, J. M., Pollakis, G., & Paxton, W. A. (2012). HIV Type 1 Mother-to-Child Transmission Facilitated by Distinctive Glycosylation Sites in the gp120 Envelope Glycoprotein. AIDS RESEARCH AND HUMAN RETROVIRUSES, 28(7), 715-724. doi:10.1089/aid.2011.0023
Effects of helminths and <i>Mycobacterium tuberculosis</i> infection on HIV-1: a cellular immunological perspective
Mouser, E. E. I. M., Pollakis, G., & Paxton, W. A. (2012). Effects of helminths and <i>Mycobacterium tuberculosis</i> infection on HIV-1: a cellular immunological perspective. CURRENT OPINION IN HIV AND AIDS, 7(3), 260-267. doi:10.1097/COH.0b013e3283521144
HIV-1 Disease Progression Is Associated with Bile-Salt Stimulated Lipase (<i>BSSL</i>) Gene Polymorphism
Stax, M. J., Kootstra, N. A., van 't Wout, A. B., Tanck, M. W. T., Bakker, M., Pollakis, G., & Paxton, W. A. (2012). HIV-1 Disease Progression Is Associated with Bile-Salt Stimulated Lipase (<i>BSSL</i>) Gene Polymorphism. PLOS ONE, 7(3). doi:10.1371/journal.pone.0032534
Transmission of Two Distinct HIV Type 1 Strains to an Individual That Were Harbored for Many Years by Another
van Werkhoven, M. B., Baan, E., Bakker, M., Jurriaans, S., Paxton, W. A., & Pollakis, G. (2012). Transmission of Two Distinct HIV Type 1 Strains to an Individual That Were Harbored for Many Years by Another. AIDS RESEARCH AND HUMAN RETROVIRUSES, 28(2), 225-227. doi:10.1089/aid.2011.0178
2011
Latency profiles of full length HIV-1 molecular clone variants with a subtype specific promoter
van der Sluis, R. M., Pollakis, G., van Gerven, M. L., Berkhout, B., & Jeeninga, R. E. (2011). Latency profiles of full length HIV-1 molecular clone variants with a subtype specific promoter. RETROVIROLOGY, 8. doi:10.1186/1742-4690-8-73
Innate immune factors associated with HIV-1 transmission
Pollakis, G., Stax, M. J., & Paxton, W. A. (2011). Innate immune factors associated with HIV-1 transmission. CURRENT OPINION IN HIV AND AIDS, 6(5), 341-347. doi:10.1097/COH.0b013e3283499e11
Binding of Human Milk to Pathogen Receptor DC-SIGN Varies with Bile Salt-Stimulated Lipase (BSSL) Gene Polymorphism
Stax, M. J., Naarding, M. A., Tanck, M. W. T., Lindquist, S., Hernell, O., Lyle, R., . . . Paxton, W. A. (2011). Binding of Human Milk to Pathogen Receptor DC-SIGN Varies with Bile Salt-Stimulated Lipase (BSSL) Gene Polymorphism. PLOS ONE, 6(2). doi:10.1371/journal.pone.0017316
Altered dynamics and differential infection profiles of lymphoid and myeloid cell subsets during acute and chronic HIV-1 infection
Centlivre, M., Legrand, N., Steingrover, R., van der Sluis, R., Grijsen, M. L., Bakker, M., . . . Pollakis, G. (2011). Altered dynamics and differential infection profiles of lymphoid and myeloid cell subsets during acute and chronic HIV-1 infection. JOURNAL OF LEUKOCYTE BIOLOGY, 89(5), 785-795. doi:10.1189/jlb.0410231
HIV-1 disease progression is associated with bile-salt stimulated lipase (BSSL) gene polymorphism
Stax, M. J., Kootstra, N. A., van't Wout, A. B., Bakker, M., Pollakis, G., & Paxton, W. A. (2011). HIV-1 disease progression is associated with bile-salt stimulated lipase (BSSL) gene polymorphism. Retrovirology, 8(Suppl 2), P65. doi:10.1186/1742-4690-8-s2-p65
2010
Preferential infection and depletion of <i>Mycobacterium tuberculosis</i>-specific CD4 T cells after HIV-1 infection
Geldmacher, C., Ngwenyama, N., Schuetz, A., Petrovas, C., Reither, K., Heeregrave, E. J., . . . Koup, R. A. (2010). Preferential infection and depletion of <i>Mycobacterium tuberculosis</i>-specific CD4 T cells after HIV-1 infection. JOURNAL OF EXPERIMENTAL MEDICINE, 207(13), 2869-2881. doi:10.1084/jem.20100090
Varied sensitivity to therapy of HIV-1 strains in CD4<SUP>+</SUP> lymphocyte sub-populations upon ART initiation
Heeregrave, E. J., Geels, M. J., Baan, E., van der Sluis, R. M., Paxton, W. A., & Pollakis, G. (2010). Varied sensitivity to therapy of HIV-1 strains in CD4<SUP>+</SUP> lymphocyte sub-populations upon ART initiation. AIDS RESEARCH AND THERAPY, 7. doi:10.1186/1742-6405-7-42
Generation of representative primary virus isolates from blood plasma after isolation of HIV-1 with CD44 MicroBeads
Cornelissen, M., Heeregrave, E. J., Zorgdrager, F., Pollakis, G., Paxton, W. A., & van der Kuyl, A. C. (2010). Generation of representative primary virus isolates from blood plasma after isolation of HIV-1 with CD44 MicroBeads. ARCHIVES OF VIROLOGY, 155(12), 2017-2022. doi:10.1007/s00705-010-0806-x
Generation of HIV-1 primary isolates representative of plasma variants using the U87.CD4 cell line
Heeregrave, E. J., Ampofo, W. K., Tetteh, J. K. A., Ofori, M., Ofori, S. B., Shah, A. S., . . . Paxton, W. A. (2010). Generation of HIV-1 primary isolates representative of plasma variants using the U87.CD4 cell line. JOURNAL OF VIROLOGICAL METHODS, 169(2), 341-350. doi:10.1016/j.jviromet.2010.08.001
HIV-1 (co)Receptors: Implications for Vaccine and Therapy Design
Pollakis, G., & Paxton, W. A. (2010). HIV-1 (co)Receptors: Implications for Vaccine and Therapy Design. CURRENT PHARMACEUTICAL DESIGN, 16(33), 3701-3715. doi:10.2174/138161210794079146
Differences in HIV Type 1 RNA Plasma Load Profile of Closely Related Cocirculating Ethiopian Subtype C Strains: C and C′
Ayele, W., Mekonnen, Y., Messele, T., Mengistu, Y., Tsegaye, A., Bakker, M., . . . Pollakis, G. (2010). Differences in HIV Type 1 RNA Plasma Load Profile of Closely Related Cocirculating Ethiopian Subtype C Strains: C and C′. AIDS RESEARCH AND HUMAN RETROVIRUSES, 26(7), 805-813. doi:10.1089/aid.2009.0152
HIV RNA levels in transmission sources only weakly predict plasma viral load in recipients
van der Kuyl, A. C., Jurriaans, S., Pollakis, G., Bakker, M., & Cornelissen, M. (2010). HIV RNA levels in transmission sources only weakly predict plasma viral load in recipients. AIDS, 24(10), 1607-1608. doi:10.1097/QAD.0b013e32833b318f
2009
Natural compounds in bodily fluids which bind DC-SIGN and prevent HIV-1 capture and transfer to CD4 cells
Stax, M. J., Pollakis, G., Sprenger, R. R., Melchers, M., van Montfort, T., Sanders, R. W., . . . Paxton, W. A. (2009). Natural compounds in bodily fluids which bind DC-SIGN and prevent HIV-1 capture and transfer to CD4 cells. In RETROVIROLOGY Vol. 6. doi:10.1186/1742-4690-6-S3-P108
Lack of <i>in vivo</i> compartmentalization among HIV-1 infected naive and memory CD4<SUP>+</SUP> T cell subsets
Heeregrave, E. J., Geels, M. J., Brenchley, J. M., Laan, E., Ambrozak, D. R., van der Sluis, R. M., . . . Paxton, W. A. (2009). Lack of <i>in vivo</i> compartmentalization among HIV-1 infected naive and memory CD4<SUP>+</SUP> T cell subsets. VIROLOGY, 393(1), 24-32. doi:10.1016/j.virol.2009.07.011
Mucin 6 in seminal plasma binds DC-SIGN and potently blocks dendritic cell mediated transfer of HIV-1 to CD4<SUP>+</SUP> T-lymphocytes
Stax, M. J., van Montfort, T., Sprenger, R. R., Melchers, M., Sanders, R. W., van Leeuwen, E., . . . Paxton, W. A. (2009). Mucin 6 in seminal plasma binds DC-SIGN and potently blocks dendritic cell mediated transfer of HIV-1 to CD4<SUP>+</SUP> T-lymphocytes. VIROLOGY, 391(2), 203-211. doi:10.1016/j.virol.2009.06.011
Use of chloroquine in reducing mother to child transmission of HIV-1 during breastfeeding
Naarding, M., Luchters, S., Vyankandondera, J., Wit, F., Veldhuijzen, N., Kankindi, B., . . . Paxton, W. (2009). Use of chloroquine in reducing mother to child transmission of HIV-1 during breastfeeding. Retrovirology, 6(S1). doi:10.1186/1742-4690-6-s1-o13
RNA detection and subtype C assessment of HIV-1 in infants with diarrhea in Ethiopia.
Ayele, W., Assefa, T., Lulseged, S., Tegbaru, B., Berhanu, H., Tamene, W., . . . Pollakis, G. (2009). RNA detection and subtype C assessment of HIV-1 in infants with diarrhea in Ethiopia.. The open AIDS journal, 3, 19-23. doi:10.2174/1874613600903010019
Optimization of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins with V1/V2 Deleted, Using Virus Evolution
Bontjer, I., Land, A., Eggink, D., Verkade, E., Tuin, K., Baldwin, C., . . . Sanders, R. W. (2009). Optimization of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins with V1/V2 Deleted, Using Virus Evolution. JOURNAL OF VIROLOGY, 83(1), 368-383. doi:10.1128/JVI.01404-08
2008
Dendritic cells preferentially transfer CXCR4-using human immunodeficiency virus type 1 variants to CD4<SUP>+</SUP> T lymphocytes in <i>trans</i>
van Montfort, T., Thomas, A. A. M., Pollakis, G., & Paxton, W. A. (2008). Dendritic cells preferentially transfer CXCR4-using human immunodeficiency virus type 1 variants to CD4<SUP>+</SUP> T lymphocytes in <i>trans</i>. JOURNAL OF VIROLOGY, 82(16), 7886-7896. doi:10.1128/JVI.00245-08
Bile-salt stimulated lipase in human milk binds DC-SIGN and inhibits HIV-1 transmission
Stax, M. J., Naarding, M. A., Speijer, D., Hernell, O., Pollakis, G., & Paxton, W. A. (2008). Bile-salt stimulated lipase in human milk binds DC-SIGN and inhibits HIV-1 transmission. Retrovirology, 5(Suppl 1), O3. doi:10.1186/1742-4690-5-s1-o3
2007
Statins Disrupt CCR5 and RANTES Expression Levels in CD4<SUP>+</SUP> T Lymphocytes In Vitro and Preferentially Decrease Infection of R5 Versus X4 HIV-1
Nabatov, A. A., Pollakis, G., Linnemann, T., Paxton, W. A., & de Baar, M. P. (2007). Statins Disrupt CCR5 and RANTES Expression Levels in CD4<SUP>+</SUP> T Lymphocytes In Vitro and Preferentially Decrease Infection of R5 Versus X4 HIV-1. PLOS ONE, 2(5). doi:10.1371/journal.pone.0000470
Characterization of an HIV-1 group m variant that is distinct from the known subtypes
Van der Hoek, L., Pollakis, G., Lukashov, V. V., Jebbink, M. F., Jeeninga, R. E., Bakker, M., . . . Berkhout, B. (2007). Characterization of an HIV-1 group m variant that is distinct from the known subtypes. AIDS RESEARCH AND HUMAN RETROVIRUSES, 23(3), 466-470. doi:10.1089/aid.2006.0184
Efficient capture of antibody neutralized HIV-1 by cells expressing DC-SIGN and transfer to CD4<SUP>+</SUP> T lymphocytes
van Montfort, T., Nabatov, A. A., Geijtenbeek, T. B. H., Pollakis, G., & Paxton, W. A. (2007). Efficient capture of antibody neutralized HIV-1 by cells expressing DC-SIGN and transfer to CD4<SUP>+</SUP> T lymphocytes. JOURNAL OF IMMUNOLOGY, 178(5), 3177-3185. doi:10.4049/jimmunol.178.5.3177
Use of dried spots of whole blood, plasma, and mother's milk collected on filter paper for measurement of human immunodeficiency virus type 1 burden
Ayele, W., Schuurman, R., Messele, T., Dorigo-Zetsma, W., Mengistu, Y., Goudsmit, J., . . . Pollakis, G. (2007). Use of dried spots of whole blood, plasma, and mother's milk collected on filter paper for measurement of human immunodeficiency virus type 1 burden. JOURNAL OF CLINICAL MICROBIOLOGY, 45(3), 891-896. doi:10.1128/JCM.01919-06
Effect of chloroquine on reducing HIV-I replication <i>in vitro</i> and the DC-SIGN mediated transfer of virus to CD<SUP>4+</SUP> T-lymphocytes
Naarding, M. A., Baan, E., Pollakis, G., & Paxton, W. A. (2007). Effect of chloroquine on reducing HIV-I replication <i>in vitro</i> and the DC-SIGN mediated transfer of virus to CD<SUP>4+</SUP> T-lymphocytes. RETROVIROLOGY, 4. doi:10.1186/1742-4690-4-6
2006
Interaction of HIV-1 with dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-expressing cells is influenced by gp120 envelope modifications associated with disease progression
Nabatov, A. A., van Montfort, T., Geijtenbeek, T. B. H., Pollakis, G., & Paxton, W. A. (2006). Interaction of HIV-1 with dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-expressing cells is influenced by gp120 envelope modifications associated with disease progression. FEBS JOURNAL, 273(21), 4944-4958. doi:10.1111/j.1742-4658.2006.05491.x
Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4<SUP>+</SUP> T cells
Naarding, M. A., Dirac, A. M., Ludwig, I. S., Speijer, D., Lindquist, S., Vestman, E. -L., . . . Paxton, W. A. (2006). Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4<SUP>+</SUP> T cells. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 50(10), 3367-3374. doi:10.1128/AAC.00593-06
CTL escape and increased viremia irrespective of HIV-specific CD4<SUP>+</SUP> T-helper responses in two HIV-infected individuals
Geels, M. J., Jansen, C. A., Baan, E., De Cuyper, I. M., van Schijndel, G. J. M., Schuitemaker, H., . . . van Baarle, D. (2006). CTL escape and increased viremia irrespective of HIV-specific CD4<SUP>+</SUP> T-helper responses in two HIV-infected individuals. VIROLOGY, 345(1), 209-219. doi:10.1016/j.virol.2005.09.023
2005
Surveillance technology for HIV-1 subtype C in ethiopia:: An <i>env-</i>based NASBA molecular beacon assay to discriminate between subcluster C and C′
Ayele, W., de Baar, M. P., Goudsmit, J., Kliphuis, A., Tilahun, T., Dorigo-Zetsma, W., . . . Pollakis, G. (2005). Surveillance technology for HIV-1 subtype C in ethiopia:: An <i>env-</i>based NASBA molecular beacon assay to discriminate between subcluster C and C′. JOURNAL OF VIROLOGICAL METHODS, 130(1-2), 22-29. doi:10.1016/j.jviromet.2005.05.028
Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4<SUP>+</SUP> T lymphocytes
Naarding, M. A., Ludwig, I. S., Groot, F., Berkhout, B., Geijtenbeek, T. B. H., Pollakis, G., & Paxton, W. A. (2005). Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4<SUP>+</SUP> T lymphocytes. JOURNAL OF CLINICAL INVESTIGATION, 115(11), 3256-3264. doi:10.1172/JCI25105
Broad cross-glade T-cell responses to gag in individuals infected with human immunodeficiency virus type 1 non-B clades (A to G): Importance of HLA anchor residue conservation
Geels, M. J., Dubey, S. A., Anderson, K., Baan, E., Bakker, M., Pollakis, G., . . . Goudsmit, J. (2005). Broad cross-glade T-cell responses to gag in individuals infected with human immunodeficiency virus type 1 non-B clades (A to G): Importance of HLA anchor residue conservation. JOURNAL OF VIROLOGY, 79(17), 11247-11258. doi:10.1128/JVI.79.17.11247-11258.2005
Evidence of genetic variability of human immunodeficiency virus type 1 in plasma and cervicovaginal lavage in Ethiopian women seeking care for sexually transmitted infections
Adal, M., Ayele, W., Wolday, D., Dagne, K., Messele, T., Tilahun, T., . . . Dorigo-Zetsma, W. (2005). Evidence of genetic variability of human immunodeficiency virus type 1 in plasma and cervicovaginal lavage in Ethiopian women seeking care for sexually transmitted infections. AIDS RESEARCH AND HUMAN RETROVIRUSES, 21(7), 649-653. doi:10.1089/aid.2005.21.649
2004
Development of a nucleic acid sequence-based amplification assay that uses <i>gag</i>-based molecular beacons to distinguish between human immunodeficiency virus type 1 subtype C and C′ infections in Ethiopia
Ayele, W., Pollakis, G., Abebe, A., Fisseha, B., Tegbaru, B., Tesfaye, G., . . . de Baar, M. P. (2004). Development of a nucleic acid sequence-based amplification assay that uses <i>gag</i>-based molecular beacons to distinguish between human immunodeficiency virus type 1 subtype C and C′ infections in Ethiopia. JOURNAL OF CLINICAL MICROBIOLOGY, 42(4), 1534-1541. doi:10.1128/JCM.42.4.1534-1541.2004
Human immunodeficiency virus type 1 subtypes have a distinct long terminal repeat that determines the replication rate in a host-cell-specific manner
van Opijnen, T., Jeeninga, R. E., Boerlijst, M. C., Pollakis, G. P., Zetterberg, V., Salminen, M., & Berkhout, B. (2004). Human immunodeficiency virus type 1 subtypes have a distinct long terminal repeat that determines the replication rate in a host-cell-specific manner. JOURNAL OF VIROLOGY, 78(7), 3675-3683. doi:10.1128/JVI.78.7.3675-3683.2004
Phenotypic and genotypic comparisons of CCR5- and CXCR4-Tropic human immunodeficiency virus type 1 biological clones isolated from subtype C-infected individuals
Pollakis, G., Abebe, A., Kliphuis, A., Chalaby, M. I. M., Bakker, M., Mengistu, Y., . . . Paxton, W. A. (2004). Phenotypic and genotypic comparisons of CCR5- and CXCR4-Tropic human immunodeficiency virus type 1 biological clones isolated from subtype C-infected individuals. JOURNAL OF VIROLOGY, 78(6), 2841-2852. doi:10.1128/JVI.78.6.2841-2852.2004
Intrapatient alterations in the human immunodeficiency virus type 1 gp120 V1V2 and V3 regions differentially modulate coreceptor usage, virus inhibition by CC/CXC chemokines, soluble CD4, and the b12 and 2G12 monoclonal antibodies
Nabatov, A. A., Pollakis, G., Linnemann, T., Kliphius, A., Chalaby, M. I. M., & Paxton, W. A. (2004). Intrapatient alterations in the human immunodeficiency virus type 1 gp120 V1V2 and V3 regions differentially modulate coreceptor usage, virus inhibition by CC/CXC chemokines, soluble CD4, and the b12 and 2G12 monoclonal antibodies. JOURNAL OF VIROLOGY, 78(1), 524-530. doi:10.1128/JVI.78.1.524-530.2004
Rapid CD4<SUP>+</SUP> T-lymphocyte depletion in rhesus monkeys infected with a simian-human immunodeficiency virus expressing the envelope glycoproteins of a primary dual-tropic Ethiopian clade C HIV type 1 isolate
Cayabyab, M., Rohne, D., Pollakis, G., Mische, C., Messele, T., Abebe, A., . . . Sodroski, J. (2004). Rapid CD4<SUP>+</SUP> T-lymphocyte depletion in rhesus monkeys infected with a simian-human immunodeficiency virus expressing the envelope glycoproteins of a primary dual-tropic Ethiopian clade C HIV type 1 isolate. AIDS RESEARCH AND HUMAN RETROVIRUSES, 20(1), 27-40. doi:10.1089/088922204322749477
2003
Recombination of HIV type 1C (C′/C") in Ethiopia:: Possible link of EthHIV-1C′ to subtype C sequences from the high-prevalence epidemics in India and southern Africa
Pollakis, G., Abebe, A., Kliphuis, A., De Wit, T. F. R., Fisseha, B., Tegbaru, B., . . . Goudsmit, J. (2003). Recombination of HIV type 1C (C′/C") in Ethiopia:: Possible link of EthHIV-1C′ to subtype C sequences from the high-prevalence epidemics in India and southern Africa. AIDS RESEARCH AND HUMAN RETROVIRUSES, 19(11), 999-1008. doi:10.1089/088922203322588350
HIV type 1 C and C′ subclusters based on long terminal repeat sequences in the Ethiopian HIV type 1 subtype C epidemic
De Baar, M. P., Abebe, A., Kliphuis, A., Tesfaye, G., Goudsmit, J., & Pollakis, G. (2003). HIV type 1 C and C′ subclusters based on long terminal repeat sequences in the Ethiopian HIV type 1 subtype C epidemic. AIDS RESEARCH AND HUMAN RETROVIRUSES, 19(10), 917-922. doi:10.1089/088922203322493094
2002
Primary HIV-1 subtype C infection in Ethiopia.
Rinke de Wit, T. F., Tsegaye, A., Wolday, D., Hailu, B., Aklilu, M., Sanders, E., . . . Fontanet, A. L. (2002). Primary HIV-1 subtype C infection in Ethiopia.. Journal of acquired immune deficiency syndromes (1999), 30(5), 463-470. doi:10.1097/00126334-200208150-00001
Primary HIV-1 subtype C infection in Ethiopia
de Wit, T. F. R., Tsegaye, A., Wolday, D., Hailu, B., Aklilu, M., Sanders, E., . . . Fontanet, A. L. (2002). Primary HIV-1 subtype C infection in Ethiopia. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 30(5), 463-470. doi:10.1097/01.QAI.0000026915.39197.99
2001
Timing of the HIV-1 subtype C epidemic in Ethiopia based on early virus strains and subsequent virus diversification
Abebe, A., Lukashov, V. V., Pollakis, G., Kliphuis, A., Fontanet, A. L., Goudsmit, J., & de Wit, T. F. R. (2001). Timing of the HIV-1 subtype C epidemic in Ethiopia based on early virus strains and subsequent virus diversification. AIDS, 15(12), 1555-1561. doi:10.1097/00002030-200108170-00013
Timing of the introduction into ethiopia of subcluster C′ of HIV type 1 subtype C
Abebe, A., Lukashov, V. V., de Wit, T. F. R., Fisseha, B., Tegbaru, B., Kliphuis, A., . . . Pollakis, G. (2001). Timing of the introduction into ethiopia of subcluster C′ of HIV type 1 subtype C. AIDS RESEARCH AND HUMAN RETROVIRUSES, 17(7), 657-661. doi:10.1089/088922201300119770
<i>N</i>-linked glycosylation of the HIV type-1 gp120 envelope glycoprotein as a major determinant of CCR5 and CXCR4 coreceptor utilization
Pollakis, G., Kang, S., Kliphuis, A., Chalaby, M. I. M., Goudsmit, J., & Paxton, W. A. (2001). <i>N</i>-linked glycosylation of the HIV type-1 gp120 envelope glycoprotein as a major determinant of CCR5 and CXCR4 coreceptor utilization. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(16), 13433-13441. doi:10.1074/jbc.M009779200
2000
Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry
Cayabyab, M., Hinuma, S., Farzan, M., Choe, H., Fukusumi, S., Kitada, C., . . . Sodroski, J. (2000). Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry. JOURNAL OF VIROLOGY, 74(24), 11972-11976. doi:10.1128/JVI.74.24.11972-11976.2000
Identification of a genetic subcluster of HIV type 1 subtype C (C′) widespread in Ethiopia
Abebe, A., Pollakis, G., Fontanet, A. L., Fisseha, B., Tegbaru, B., Kliphuis, A., . . . De Wit, T. F. R. (2000). Identification of a genetic subcluster of HIV type 1 subtype C (C′) widespread in Ethiopia. AIDS RESEARCH AND HUMAN RETROVIRUSES, 16(17), 1909-1914. doi:10.1089/08892220050195865
HIV-1 Subtype C in Commercial Sex Workers in Addis Ababa, Ethiopia
Hussein, M., Abebe, A., Pollakis, G., Brouwer, M., Petros, B., Fontanet, A. L., & Rinke de Wit, T. F. (2000). HIV-1 Subtype C in Commercial Sex Workers in Addis Ababa, Ethiopia. Journal of Acquired Immune Deficiency Syndromes, 23(2), 120-127. doi:10.1097/00042560-200002010-00003
HIV-1 subtype C in commercial sex workers in Addis Ababa, Ethiopia
Hussein, M., Abebe, A., Pollakis, G., Brouwer, M., Petros, B., Fontanet, A. L., & de Wit, T. F. R. (2000). HIV-1 subtype C in commercial sex workers in Addis Ababa, Ethiopia. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 23(2), 120-127. Retrieved from https://www.webofscience.com/
1999
HIV-1 subtype C syncytium- and non-syncytium-inducing phenotypes and coreceptor usage among Ethiopian patients with AIDS
Abebe, A., Demissie, D., Goudsmit, J., Brouwer, M., Kuiken, C. L., Pollakis, G., . . . de Wit, T. F. R. (1999). HIV-1 subtype C syncytium- and non-syncytium-inducing phenotypes and coreceptor usage among Ethiopian patients with AIDS. AIDS, 13(11), 1305-1311. doi:10.1097/00002030-199907300-00006
1995
COMPETITION BETWEEN INHIBITORS OF THE TRYPANOSOME ALTERNATIVE OXIDASE (TAO) AND REDUCED COENZYME Q(9)
POLLAKIS, G., GRADY, R. W., DIECK, H. A., & CLARKSON, A. B. (1995). COMPETITION BETWEEN INHIBITORS OF THE TRYPANOSOME ALTERNATIVE OXIDASE (TAO) AND REDUCED COENZYME Q(9). BIOCHEMICAL PHARMACOLOGY, 50(8), 1207-1210. doi:10.1016/0006-2952(95)00259-3
1993
NON-CYTOCHROME MEDIATED MITOCHONDRIAL ATP PRODUCTION IN BLOOD-STREAM FORM TRYPANOSOMA-BRUCEI-BRUCEI
BIENEN, E. J., MATURI, R. K., POLLAKIS, G., & CLARKSON, A. B. (1993). NON-CYTOCHROME MEDIATED MITOCHONDRIAL ATP PRODUCTION IN BLOOD-STREAM FORM TRYPANOSOMA-BRUCEI-BRUCEI. EUROPEAN JOURNAL OF BIOCHEMISTRY, 216(1), 75-80. doi:10.1111/j.1432-1033.1993.tb18118.x
1991
MITOCHONDRIAL DEVELOPMENT IN TRYPANOSOMA-BRUCEI-BRUCEI TRANSITIONAL BLOOD-STREAM FORMS
BIENEN, E. J., SARIC, M., POLLAKIS, G., GRADY, R. W., & CLARKSON, A. B. (1991). MITOCHONDRIAL DEVELOPMENT IN TRYPANOSOMA-BRUCEI-BRUCEI TRANSITIONAL BLOOD-STREAM FORMS. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 45(2), 185-192. doi:10.1016/0166-6851(91)90085-K
1989
RESPIRATION OF BLOOD-STREAM FORMS OF THE PARASITE TRYPANOSOMA-BRUCEI-BRUCEI IS DEPENDENT ON A PLANT-LIKE ALTERNATIVE OXIDASE
CLARKSON, A. B., BIENEN, E. J., POLLAKIS, G., & GRADY, R. W. (1989). RESPIRATION OF BLOOD-STREAM FORMS OF THE PARASITE TRYPANOSOMA-BRUCEI-BRUCEI IS DEPENDENT ON A PLANT-LIKE ALTERNATIVE OXIDASE. JOURNAL OF BIOLOGICAL CHEMISTRY, 264(30), 17770-17776. Retrieved from https://www.webofscience.com/
TRYPANOCIDAL COQ ANALOGS - THEIR EFFECT ON OTHER MITOCHONDRIAL SYSTEMS
CLARKSON, A. B., BIENEN, E. J., POLLAKIS, G., & GRADY, R. W. (1989). TRYPANOCIDAL COQ ANALOGS - THEIR EFFECT ON OTHER MITOCHONDRIAL SYSTEMS. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 94(2), 245-251. doi:10.1016/0305-0491(89)90341-6
1988
A NEW CLASS OF FREE-RADICAL SCAVENGERS REDUCING ADRIAMYCIN MITOCHONDRIAL TOXICITY
PRAET, M., CALDERON, P. B., POLLAKIS, G., ROBERFROID, M., & RUYSSCHAERT, J. M. (1988). A NEW CLASS OF FREE-RADICAL SCAVENGERS REDUCING ADRIAMYCIN MITOCHONDRIAL TOXICITY. BIOCHEMICAL PHARMACOLOGY, 37(24), 4617-4622. doi:10.1016/0006-2952(88)90329-2
1986
INVIVO AND INVITRO MODIFICATIONS OF THE MITOCHONDRIAL-MEMBRANE INDUCED BY 4' EPI-ADRIAMYCIN
PRAET, M., LAGHMICHE, M., POLLAKIS, G., GOORMAGHTIGH, E., & RUYSSCHAERT, J. M. (1986). INVIVO AND INVITRO MODIFICATIONS OF THE MITOCHONDRIAL-MEMBRANE INDUCED BY 4' EPI-ADRIAMYCIN. BIOCHEMICAL PHARMACOLOGY, 35(17), 2923-2928. doi:10.1016/0006-2952(86)90487-9
1984
DAMAGES OF THE MITOCHONDRIAL-MEMBRANE IN ADRIAMYCIN TREATED MICE
PRAET, M., POLLAKIS, G., GOORMAGHTIGH, E., & RUYSSCHAERT, J. M. (1984). DAMAGES OF THE MITOCHONDRIAL-MEMBRANE IN ADRIAMYCIN TREATED MICE. CANCER LETTERS, 25(1), 89-96. doi:10.1016/S0304-3835(84)80030-0
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ROLE OF THE QUINONE STRUCTURE IN THE MITOCHONDRIAL DAMAGE INDUCED BY ANTI-TUMOR ANTHRACYCLINES - COMPARISON OF ADRIAMYCIN AND 5-IMINODAUNORUBICIN
POLLAKIS, G., GOORMAGHTIGH, E., & RUYSSCHAERT, J. M. (1983). ROLE OF THE QUINONE STRUCTURE IN THE MITOCHONDRIAL DAMAGE INDUCED BY ANTI-TUMOR ANTHRACYCLINES - COMPARISON OF ADRIAMYCIN AND 5-IMINODAUNORUBICIN. FEBS LETTERS, 155(2), 267-272. doi:10.1016/0014-5793(82)80618-2
MITOCHONDRIAL-MEMBRANE MODIFICATIONS INDUCED BY ADRIAMYCIN-MEDIATED ELECTRON-TRANSPORT
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