Research
Understanding the role of post transcriptional gene regulation in musculoskeletal disease.
My group is interested in the biology of cells within our joints and in understanding mechanisms that lead to age-related musculoskeletal diseases such as osteoarthritis and osteoporosis. We are particularly interested in novel ways in which genes are controlled in these tissues. We are focussing on post-transcriptional regulation and have ongoing studies into the effects of mRNA decay, polyadenylation and RNA binding protein function in skeletal pathology.
We use a range of in vivo and in vitro experimental model systems and employ an equally wide range of techniques to analyse these systems, spanning cutting edge transcriptomic analysis of cellular systems, studies of molecular interaction, gene and protein expression analysis and tissue imaging.
Research grants
Sara Ibrahim AlSalhi 201369309 bench fees
ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)
March 2020 - February 2024
Improving the annotation of genes across the equine genome
HORSERACE BETTING LEVY BOARD (UK)
November 2022 - February 2024
Bench fees - Haifa Mohammed A Majali - (201773323)
ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)
February 2024 - January 2028
Bench fees - Maryam Saad D Alotaibi (201772012)
ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)
November 2023 - October 2027
INVESTIGATING THE ROLE OF THE RNA BINDING PROTEIN HuR IN MUSCULOSKELETAL DEVELOPMENT AND DISEASE
MEDICAL RESEARCH COUNCIL
July 2016 - December 2019
Anti-cytokine gene silencing in canine synovial cells
PET PLAN CHARITABLE TRUST (UK)
January 2012 - December 2013
Defining the post-transcriptional regulatory mechanisms controlling a gene that performs an essential role in cartilage function and regeneration
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
December 2012 - November 2015