Publications

Selected publications

Translational regulation contributes to the secretory response of chondrocytic cells following exposure to Interleukin-1β (Journal article - 2019)
Cross-species gene modules emerge from a systems biology approach to osteoarthritis (Journal article - 2017)
A systems biology approach to defining regulatory mechanisms for cartilage and tendon cell phenotypes (Journal article - 2016)
RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes (Journal article - 2016)
Transcriptome‐Wide Analysis of Messenger RNA Decay in Normal and Osteoarthritic Human Articular Chondrocytes (Journal article - 2014)

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2023

Analysis of RNA Polyadenylation in Healthy and Osteoarthritic Human Articular Cartilage

Winstanley-Zarach, P., Rot, G., Kuba, S., Smagul, A., Peffers, M. J. J., & Tew, S. R. R. (2023). Analysis of RNA Polyadenylation in Healthy and Osteoarthritic Human Articular Cartilage. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(7). doi:10.3390/ijms24076611

DOI: 10.3390/ijms24076611
: Journal article

Editorial: Epigenetic regulation of the musculoskeletal system in health, disease, and aging

Goljanek-Whysall, K., Tew, S., Peffers, M. J., & Kanakis, I. (2023). Editorial: Epigenetic regulation of the musculoskeletal system in health, disease, and aging. FRONTIERS IN ENDOCRINOLOGY, 14. doi:10.3389/fendo.2023.1143210

DOI: 10.3389/fendo.2023.1143210
: Journal article

2022

Chondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations

Al-Maslamani, N. A., Oldershaw, R., Tew, S., Curran, J., D'Hooghe, P., Yamamoto, K., & Horn, H. F. (2022). Chondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations. CELLS, 11(24). doi:10.3390/cells11244011

DOI: 10.3390/cells11244011
: Journal article

2021

Characterisation of key proteoglycans in the cranial cruciate ligaments (CCLs) from two dog breeds with different predispositions to CCL disease and rupture.

Allaith, S., Tew, S. R., Hughes, C. E., Clegg, P. D., Canty-Laird, E. G., & Comerford, E. J. (2021). Characterisation of key proteoglycans in the cranial cruciate ligaments (CCLs) from two dog breeds with different predispositions to CCL disease and rupture.. Veterinary journal (London, England : 1997), 272, 105657. doi:10.1016/j.tvjl.2021.105657

DOI: 10.1016/j.tvjl.2021.105657
: Journal article

2019

Insulin-like growth factor binding protein (IGFBP6) is a cross-species tendon marker.

Turlo, A. J., Mueller-Breckenridge, A. J., Zamboulis, D. E., Tew, S. R., Canty-Laird, E. G., & Clegg, P. D. (2019). Insulin-like growth factor binding protein (IGFBP6) is a cross-species tendon marker.. European Cells and Materials, 38, 123-136. doi:10.22203/ecm.v038a10

DOI: 10.22203/ecm.v038a10
: Journal article

Translational regulation contributes to the secretory response of chondrocytic cells following exposure to Interleukin-1β

Mcdermott, B., Peffers, M., McDonagh, B., & Tew, S. R. (2019). Translational regulation contributes to the secretory response of chondrocytic cells following exposure to Interleukin-1β. Journal of Biological Chemistry, 294(35), 13027-13029. doi:10.1074/jbc.RA118.006865

DOI: 10.1074/jbc.RA118.006865
: Journal article

Evidence for alternative polyadenylation of the ADAMTS5 mRNA creating a heterogenous pool of transcripts that differ in their response to post-transcriptional cues

McDermott, B. T., Chinaemerem, O., Chesters, L., & Tew, S. R. (2019). Evidence for alternative polyadenylation of the ADAMTS5 mRNA creating a heterogenous pool of transcripts that differ in their response to post-transcriptional cues. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A27). Retrieved from https://www.webofscience.com/

: Conference Paper

2018

The emerging fibroblast-like synoviocyte channelome

Tew, S. R., & Barrett-Jolley, R. (2018). The emerging fibroblast-like synoviocyte channelome. EXPERIMENTAL PHYSIOLOGY, 103(8), 1043-1044. doi:10.1113/EP087087

DOI: 10.1113/EP087087
: Journal article

Variations in internal structure, composition and protein distribution between intra- and extra-articular knee ligaments and tendons

Kharaz, Y. A., Canty-Laird, E. G., Tew, S. R., & Comerford, E. J. (2018). Variations in internal structure, composition and protein distribution between intra- and extra-articular knee ligaments and tendons. JOURNAL OF ANATOMY, 232(6), 943-955. doi:10.1111/joa.12802

DOI: 10.1111/joa.12802
: Journal article

CHARACTERISATION OF STEM CELL POPULATIONS WITHIN NORMAL AND RUPTURED ANTERIOR CRUCIATE LIGAMENTS'

Barrow, M., Tew, S., Comerford, E., McNicholas, M., & Oldershaw, R. (2018). CHARACTERISATION OF STEM CELL POPULATIONS WITHIN NORMAL AND RUPTURED ANTERIOR CRUCIATE LIGAMENTS'. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S405-S406). doi:10.1016/j.joca.2018.02.786

DOI: 10.1016/j.joca.2018.02.786
: Conference Paper

THE EFFECT OF U3 SNORNA KNOCKDOWN ON THE CHONDROCYTE PROTEOME

Smagul, A., Tew, S., & Peffers, M. J. (2018). THE EFFECT OF U3 SNORNA KNOCKDOWN ON THE CHONDROCYTE PROTEOME. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S165). doi:10.1016/j.joca.2018.02.359

DOI: 10.1016/j.joca.2018.02.359
: Conference Paper

Interaction with macrophages attenuates equine fibroblast-like synoviocyte ADAMTS5 (aggrecanase-2) gene expression following inflammatory stimulation

Morgan, R. E., Clegg, P. D., Hunt, J. A., Innes, J. F., & Tew, S. R. (2018). Interaction with macrophages attenuates equine fibroblast-like synoviocyte ADAMTS5 (aggrecanase-2) gene expression following inflammatory stimulation. JOURNAL OF ORTHOPAEDIC RESEARCH, 36(08), 2178-2185. doi:10.1002/jor.23891

DOI: 10.1002/jor.23891
: Journal article

2017

Cross-species gene modules emerge from a systems biology approach to osteoarthritis

Mueller, A. J., Canty-Laird, E. G., Clegg, P. D., & Tew, S. R. (2017). Cross-species gene modules emerge from a systems biologyapproach to osteoarthritis. NPJ Systems Biology and Applications, 3. doi:10.1038/s41540-017-0014-3

DOI: 10.1038/s41540-017-0014-3
: Journal article

2016

A systems biology approach to defining regulatory mechanisms for cartilage and tendon cell phenotypes

Mueller, A. J., Tew, S. R., Vasieva, O., Clegg, P. D., & Canty-Laird, E. G. (2016). A systems biology approach to defining regulatory mechanisms for cartilage and tendon cell phenotypes. SCIENTIFIC REPORTS, 6, 1-14. doi:10.1038/srep33956

DOI: 10.1038/srep33956
: Journal article

RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes

McDermott, B., Ellis, S., Bou-Gharios, G., Clegg, P., & Tew, S. (2016). RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes. Osteoarthritis and Cartilage, 24(7), 1263-1273. doi:10.1016/j.joca.2016.01.988

DOI: 10.1016/j.joca.2016.01.988
: Journal article

Proteomic differences between native and tissue-engineered tendon and ligament

Kharaz, Y. A., Tew, S. R., Peffers, M., Canty-Laird, E. G., & Comerford, E. (2016). Proteomic differences between native and tissue-engineered tendon and ligament. PROTEOMICS, 16(10), 1547-1556. doi:10.1002/pmic.201500459

DOI: 10.1002/pmic.201500459
: Journal article

Modest, transient high-glucose exposure has the potential to alter DNA methylation profiles of musculoskeletal cells and induce DNA damage

Tregilgas, L., Reynard, L., Tew, S., Loughlin, J., Clegg, P., & Canty-Laird, E. (2016). Modest, transient high-glucose exposure has the potential to alter DNA methylation profiles of musculoskeletal cells and induce DNA damage. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A14). Retrieved from https://www.webofscience.com/

: Conference Paper

2015

PI-3K signalling is a consensus pathway in musculoskeletal de- and re-differentiation

Mueller, A. J., Tew, S. R., Canty-Laird, E. G., & Clegg, P. D. (2015). PI-3K signalling is a consensus pathway in musculoskeletal de- and re-differentiation. In Bone and Joint Journal Vol. 97-B. British Editorial Society of Bone and Joint Surgery. Retrieved from http://www.bjjprocs.boneandjoint.org.uk/content/97-B/SUPP_11/8

: Conference Paper

Magnetic resonance compositional imaging of articular cartilage: What can we expect in veterinary medicine?

Hontoir, F., Clegg, P., Nisolle, J. -F., Tew, S., & Vandeweerd, J. -M. (2015). Magnetic resonance compositional imaging of articular cartilage: What can we expect in veterinary medicine?. VETERINARY JOURNAL, 205(1), 11-20. doi:10.1016/j.tvjl.2015.04.035

DOI: 10.1016/j.tvjl.2015.04.035
: Journal article

The effects of adiopokines on canine cruciate ligament and meniscus

Saengsoi, W., Tew, S., Janssens, B., Bing, C., Comerford, E., & German, A. (2015). The effects of adiopokines on canine cruciate ligament and meniscus. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 96(2), A19. Retrieved from https://www.webofscience.com/

: Journal article

2014

Transcriptome‐Wide Analysis of Messenger RNA Decay in Normal and Osteoarthritic Human Articular Chondrocytes

Tew, S., McDermott, B., Fentem, R. B., Peffers, M., & Clegg, P. (2014). Transcriptome‐Wide Analysis of Messenger RNA Decay in Normal and Osteoarthritic Human Articular Chondrocytes. Arthritis and Rheumatology, 66(11), 3052-3061. doi:10.1002/art.38849

DOI: 10.1002/art.38849
: Journal article

Identifying key proteoglycans in different regions of canine cranial cruciate ligament

Allaith, M. S., Tew, S., Clegg, P. D., Laird, E., Comerford, E., & Caterson, B. (2014). Identifying key proteoglycans in different regions of canine cranial cruciate ligament. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 95 (pp. A2-A3). Retrieved from https://www.webofscience.com/

: Conference Paper

A COMPARISON OF THE EXTRACELLULAR MATRIX COMPOSITION OF TENDON/LIGAMENT TISSUE AND TISSUE ENGINEERED TENDON AND LIGAMENT CONSTRUCT

Kharaz, Y. A., Tew, S., Canty-Laird, E., & Comerford, E. (2014). A COMPARISON OF THE EXTRACELLULAR MATRIX COMPOSITION OF TENDON/LIGAMENT TISSUE AND TISSUE ENGINEERED TENDON AND LIGAMENT CONSTRUCT. In OSTEOARTHRITIS AND CARTILAGE Vol. 22 (pp. S313). doi:10.1016/j.joca.2014.02.580

DOI: 10.1016/j.joca.2014.02.580
: Conference Paper

THE IDENTIFICATION AND DISTRIBUTION OF KEY PROTEOGLYCANS IN CANINE CRUCIATE LIGAMENT

Allaith, S., Clegg, P. D., Canty-Laird, E. G., Tew, S., Caterson, B., & Comerford, E. (2014). THE IDENTIFICATION AND DISTRIBUTION OF KEY PROTEOGLYCANS IN CANINE CRUCIATE LIGAMENT. In OSTEOARTHRITIS AND CARTILAGE Vol. 22 (pp. S332-S333). doi:10.1016/j.joca.2014.02.614

DOI: 10.1016/j.joca.2014.02.614
: Conference Paper

BIOCHEMICAL COMPOSITION OF CARTILAGE WITH NATURALLY OCCURRING DEFECTS IN THE OVINE FEMORO-TIBIAL JOINT

Matagne, A., Clegg, P., Tew, S., Kirschvink, N., Gustin, P., Meirlaen, P., . . . Vandeweerd, J. M. (2014). BIOCHEMICAL COMPOSITION OF CARTILAGE WITH NATURALLY OCCURRING DEFECTS IN THE OVINE FEMORO-TIBIAL JOINT. In OSTEOPOROSIS INTERNATIONAL Vol. 25 (pp. S192). Retrieved from https://www.webofscience.com/

: Conference Paper

Biochemical comparison of the extracellular matrix composition of tendon/ligament tissue and tissue engineered tendon/ligament constructs

Kharaz, A. K. A., Tew, S. R. T., Laird, E. G. L., & Comerford, E. C. (2014). Biochemical comparison of the extracellular matrix composition of tendon/ligament tissue and tissue engineered tendon/ligament constructs. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 95 (pp. A4-A5). Retrieved from https://www.webofscience.com/

: Conference Paper

2013

TRANSCRIPTOMIC SIGNATURES IN CARTILAGE AGEING

Peffers, M. J., Tew, S. R., & Clegg, P. D. (2013). TRANSCRIPTOMIC SIGNATURES IN CARTILAGE AGEING. In OSTEOARTHRITIS AND CARTILAGE Vol. 21 (pp. S9). doi:10.1016/j.joca.2013.02.040

DOI: 10.1016/j.joca.2013.02.040
: Conference Paper

Myocardial cytokine expression in dogs with systemic and naturally occurring cardiac diseases

Fonfara, S., Hetzel, U., Tew, S. R., Cripps, P., Dukes-McEwan, J., & Clegg, P. D. (2013). Myocardial cytokine expression in dogs with systemic and naturally occurring cardiac diseases. AMERICAN JOURNAL OF VETERINARY RESEARCH, 74(3), 408-416. doi:10.2460/ajvr.74.3.408

DOI: 10.2460/ajvr.74.3.408
: Journal article

Expression of matrix metalloproteinases, their inhibitors, and lysyl oxidase in myocardial samples from dogs with end-stage systemic and cardiac diseases

Fonfara, S., Hetzel, U., Tew, S. R., Cripps, P., Dukes-McEwan, J., & Clegg, P. D. (2013). Expression of matrix metalloproteinases, their inhibitors, and lysyl oxidase in myocardial samples from dogs with end-stage systemic and cardiac diseases. AMERICAN JOURNAL OF VETERINARY RESEARCH, 74(2), 216-223. doi:10.2460/ajvr.74.2.216

DOI: 10.2460/ajvr.74.2.216
: Journal article

CANINE DILATED CARDIOMYOPATHY IS ASSOCIATED WITH INCREASED MYOCARDIAL ICAM1 EXPRESSION

Fonfara, S., Hetzel, U., Oyama, M., Tew, S. R., & Kipar, A. (2013). CANINE DILATED CARDIOMYOPATHY IS ASSOCIATED WITH INCREASED MYOCARDIAL ICAM1 EXPRESSION. In JOURNAL OF COMPARATIVE PATHOLOGY Vol. 148 (pp. 99). doi:10.1016/j.jcpa.2012.11.213

DOI: 10.1016/j.jcpa.2012.11.213
: Conference Paper

Gene expression alterations in tendon-derived cells after serial passage in 2D cell culture

Mueller, A. J., Tew, S. R., Vasieva, O., Clegg, P. D., & Canty-Laird, E. G. (2013). Gene expression alterations in tendon-derived cells after serial passage in 2D cell culture. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 94 (pp. A4-A5). Retrieved from https://www.webofscience.com/

: Conference Paper

Investigating the post-transcriptional regulatory mechanisms controlling SOX9 in chondrocytes

McDermott, B. T., Clegg, P. D., & Tew, S. R. (2013). Investigating the post-transcriptional regulatory mechanisms controlling SOX9 in chondrocytes. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 94 (pp. A14-A15). Retrieved from https://www.webofscience.com/

: Conference Paper

2012

Increased blood mRNA expression of inflammatory and anti-fibrotic markers in dogs with congestive heart failure

Fonfara, S., Tew, S. R., Cripps, P., Dukes-McEwan, J., & Clegg, P. D. (2012). Increased blood mRNA expression of inflammatory and anti-fibrotic markers in dogs with congestive heart failure. RESEARCH IN VETERINARY SCIENCE, 93(2), 879-885. doi:10.1016/j.rvsc.2011.10.020

DOI: 10.1016/j.rvsc.2011.10.020
: Journal article

GLOBAL GENE EXPRESSION ANALYSIS OF DEDIFFERENTIATED CHONDROCYTES

Mueller, A. J., Laird, E. G., Tew, S. R., & Clegg, P. D. (2012). GLOBAL GENE EXPRESSION ANALYSIS OF DEDIFFERENTIATED CHONDROCYTES. In RHEUMATOLOGY Vol. 51 (pp. 49). Retrieved from https://www.webofscience.com/

: Conference Paper

Fat pad-derived mesenchymal stem cells as a potential source for cell-based adipose tissue repair strategies

Khan, W. S., Adesida, A. B., Tew, S. R., Longo, U. G., & Hardingham, T. E. (2012). Fat pad-derived mesenchymal stem cells as a potential source for cell-based adipose tissue repair strategies. CELL PROLIFERATION, 45(2), 111-120. doi:10.1111/j.1365-2184.2011.00804.x

DOI: 10.1111/j.1365-2184.2011.00804.x
: Journal article

SUBSTANTIAL ALTERATION OF POST-TRANSCRIPTIONAL GENE CONTROL IN CHONDROCYTES FROM OSTEOARTHRITIC JOINTS

Tew, S. R., McDermott, B., Vasieva, O., & Clegg, P. D. (2012). SUBSTANTIAL ALTERATION OF POST-TRANSCRIPTIONAL GENE CONTROL IN CHONDROCYTES FROM OSTEOARTHRITIC JOINTS. OSTEOARTHRITIS AND CARTILAGE, 20, S43. doi:10.1016/j.joca.2012.02.582

DOI: 10.1016/j.joca.2012.02.582
: Journal article

MYOCARDIAL ICAM1 MRNA IS INCREASED IN CANINE DILATED CARDIOMYOPATHY.

Fonfara, S., Oyama, M. A., Cripps, P., Tew, S. R., & Clegg, P. D. (2012). MYOCARDIAL ICAM1 MRNA IS INCREASED IN CANINE DILATED CARDIOMYOPATHY.. JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(3), 716. Retrieved from https://www.webofscience.com/

: Journal article

2011

Leptin Expression in Dogs with Cardiac Disease and Congestive Heart Failure

Fonfara, S., Hetzel, U., Tew, S. R., Dukes-Mcewan, J., Cripps, P., & Clegg, P. D. (2011). Leptin Expression in Dogs with Cardiac Disease and Congestive Heart Failure. JOURNAL OF VETERINARY INTERNAL MEDICINE, 25(5), 1017-1024. doi:10.1111/j.1939-1676.2011.00782.x

DOI: 10.1111/j.1939-1676.2011.00782.x
: Journal article

Post-transcriptional gene regulation following exposure of osteoarthritic human articular chondrocytes to hyperosmotic conditions

Tew, S. R., Vasieva, O., Peffers, M. J., & Clegg, P. D. (2011). Post-transcriptional gene regulation following exposure of osteoarthritic human articular chondrocytes to hyperosmotic conditions. OSTEOARTHRITIS AND CARTILAGE, 19(8), 1036-1046. doi:10.1016/j.joca.2011.04.015

DOI: 10.1016/j.joca.2011.04.015
: Journal article

Analysis of Post Transcriptional Regulation of SOX9 mRNA During <i>In Vitro</i> Chondrogenesis

Tew, S. R., & Clegg, P. D. (2011). Analysis of Post Transcriptional Regulation of SOX9 mRNA During <i>In Vitro</i> Chondrogenesis. TISSUE ENGINEERING PART A, 17(13-14), 1801-1807. doi:10.1089/ten.tea.2010.0579

DOI: 10.1089/ten.tea.2010.0579
: Journal article

Development of a luciferase-based reporter system to analyse post-transcriptional gene regulation in osteoarthritis

McDermott, B. T., Tew, S. R., & Clegg, P. D. (2011). Development of a luciferase-based reporter system to analyse post-transcriptional gene regulation in osteoarthritis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 92 (pp. A31-A32). Retrieved from https://www.webofscience.com/

: Conference Paper

LEPTIN EXPRESSION IN BLOOD AND MYOCARDIAL SAMPLES OF DOGS WITH CARDIAC DISEASE

Fonfara, S., Hetzel, U., Tew, S. R., Dukes-McEwan, J., & Clegg, P. D. (2011). LEPTIN EXPRESSION IN BLOOD AND MYOCARDIAL SAMPLES OF DOGS WITH CARDIAC DISEASE. JOURNAL OF VETERINARY INTERNAL MEDICINE, 25(3), 649-650. Retrieved from https://www.webofscience.com/

: Journal article

Optimisation of osteogenic and chondrogenic differentiation potential using clonal mesenchymal stem cell populations derived from synovial fat pad

Khan, W. S., Tew, S. R., Adesida, A. B., Andrew, J. Q., & Hardingham, T. E. (2011). Optimisation of osteogenic and chondrogenic differentiation potential using clonal mesenchymal stem cell populations derived from synovial fat pad. In European Cells and Materials Vol. 22 (pp. 56).

: Conference Paper

Regulation of SOX9 mRNA decay correlates with overall SOX9 levels in human articular chondrocytes: evidence for the involvement of the RNA binding protein tristetraprolin

Tew, S. R., & Clegg, P. D. (2011). Regulation of SOX9 mRNA decay correlates with overall SOX9 levels in human articular chondrocytes: evidence for the involvement of the RNA binding protein tristetraprolin. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 92 (pp. A31). Retrieved from https://www.webofscience.com/

: Conference Paper

2010

Post-transcriptional gene regulation in chondrocytes

Tew, S. R., & Clegg, P. D. (2010). Post-transcriptional gene regulation in chondrocytes. BIOCHEMICAL SOCIETY TRANSACTIONS, 38, 1627-1631. doi:10.1042/BST0381627

DOI: 10.1042/BST0381627
: Journal article

Regulation of SOX9 in normal and osteoarthritic equine articular chondrocytes by hyperosmotic loading

Peffers, M. J., Milner, P. I., Tew, S. R., & Clegg, P. D. (2010). Regulation of SOX9 in normal and osteoarthritic equine articular chondrocytes by hyperosmotic loading. OSTEOARTHRITIS AND CARTILAGE, 18(11), 1502-1508. doi:10.1016/j.joca.2010.08.011

DOI: 10.1016/j.joca.2010.08.011
: Journal article

CYCLICAL HYPEROSMOLAR LOADING OF HUMAN ARTICULAR CHONDROCYTES INCREASES SOX9 GENE EXPRESSION AND P38 SIGNALLING IS REQUIRED

Peffers, M. J., Clegg, P. D., Tew, S., & Milne, P. I. (2010). CYCLICAL HYPEROSMOLAR LOADING OF HUMAN ARTICULAR CHONDROCYTES INCREASES SOX9 GENE EXPRESSION AND P38 SIGNALLING IS REQUIRED. In OSTEOARTHRITIS AND CARTILAGE Vol. 18 (pp. S125). doi:10.1016/S1063-4584(10)60306-8

DOI: 10.1016/S1063-4584(10)60306-8
: Conference Paper

IDENTIFICATION OF POST-TRANSCRIPTIONALLY REGULATED GENES FOLLOWING EXPOSURE OF HUMAN ARTICULAR CHONDROCYTES TO HYPEROSMOTIC CONDITIONS

Tew, S. R., & Clegg, P. D. (2010). IDENTIFICATION OF POST-TRANSCRIPTIONALLY REGULATED GENES FOLLOWING EXPOSURE OF HUMAN ARTICULAR CHONDROCYTES TO HYPEROSMOTIC CONDITIONS. In OSTEOARTHRITIS AND CARTILAGE Vol. 18 (pp. S99). doi:10.1016/S1063-4584(10)60237-3

DOI: 10.1016/S1063-4584(10)60237-3
: Conference Paper

Bone Marrow-Derived Mesenchymal Stem Cells Express the Pericyte Marker 3G5 in Culture and Show Enhanced Chondrogenesis in Hypoxic Conditions

Khan, W. S., Adesida, A. B., Tew, S. R., Lowe, E. T., & Hardingham, T. E. (2010). Bone Marrow-Derived Mesenchymal Stem Cells Express the Pericyte Marker 3G5 in Culture and Show Enhanced Chondrogenesis in Hypoxic Conditions. JOURNAL OF ORTHOPAEDIC RESEARCH, 28(6), 834-840. doi:10.1002/jor.21043

DOI: 10.1002/jor.21043
: Journal article

Bone and Cartilage Biology - lessons from development, vascular interactions and dysplasias

Brakspear, K., Culley, K., Davidson, R., Sofat, N., & Tew, S. (2010). Bone and Cartilage Biology - lessons from development, vascular interactions and dysplasias. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 91 (pp. A1-A14). Retrieved from https://www.webofscience.com/

: Conference Paper

CYTOKINE AND MATRIX METALLOPROTEINASE EXPRESSION IN BLOOD SAMPLES OF DOGS WITH CONGESTIVE HEART FAILURE

Fonfara, S., Tew, S., Clegg, P., & Dukes-McEwan, J. (2010). CYTOKINE AND MATRIX METALLOPROTEINASE EXPRESSION IN BLOOD SAMPLES OF DOGS WITH CONGESTIVE HEART FAILURE. In JOURNAL OF VETERINARY INTERNAL MEDICINE Vol. 24 (pp. 671). Retrieved from https://www.webofscience.com/

: Conference Paper

Clonal esenchymal stem cell populations derived from the synovial fat pad exhibit a similar cell surface characterisation profile but variable osteogenic and chondrogenic differentiation potential

Khan, W. S., Tew, S. R., Adesida, A., Andrew, J. G., & Hardingham, T. E. (2010). Clonal esenchymal stem cell populations derived from the synovial fat pad exhibit a similar cell surface characterisation profile but variable osteogenic and chondrogenic differentiation potential. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 91 (pp. A19-A20). Retrieved from https://www.webofscience.com/

: Conference Paper

Hyperosmotic stimulation of chondrocytes leads to differential post transcriptional regulation of SOX9 and COL2A1 mRNA: potential role for the RNA binding proteins TTP and AUF1?

Tew, S. R., & Clegg, P. D. (2010). Hyperosmotic stimulation of chondrocytes leads to differential post transcriptional regulation of SOX9 and COL2A1 mRNA: potential role for the RNA binding proteins TTP and AUF1?. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 91 (pp. A38-A39). Retrieved from https://www.webofscience.com/

: Conference Paper

The MEK-ERK signalling pathway plays a role in SOX9 gene expression in human articular chondrocytes

Peffers, M. J., Tew, S. R., Milner, P. I., & Clegg, P. D. (2010). The MEK-ERK signalling pathway plays a role in SOX9 gene expression in human articular chondrocytes. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 91 (pp. A38). Retrieved from https://www.webofscience.com/

: Conference Paper

2009

Hyperosmolarity regulates SOX9 mRNA posttranscriptionally in human articular chondrocytes

Tew, S. R., Peffers, M. J., McKay, T. R., Lowe, E. T., Khan, W. S., Hardingham, T. E., & Clegg, P. D. (2009). Hyperosmolarity regulates SOX9 mRNA posttranscriptionally in human articular chondrocytes. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 297(4), C898-C906. doi:10.1152/ajpcell.00571.2008

DOI: 10.1152/ajpcell.00571.2008
: Journal article

The epitope characterisation and the osteogenic differentiation potential of human fat pad-derived stem cells is maintained with ageing in later life

Khan, W. S., Adesida, A. B., Tew, S. K., Andrew, J. G., & Hardingham, T. E. (2009). The epitope characterisation and the osteogenic differentiation potential of human fat pad-derived stem cells is maintained with ageing in later life. INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 40(2), 150-157. doi:10.1016/j.injury.2008.05.029

DOI: 10.1016/j.injury.2008.05.029
: Journal article

The influence of donor and hypoxic conditions on the assembly of cartilage matrix by osteoarthritic human articular chondrocytes on Hyalograft matrices

Katopodi, T., Tew, S. R., Clegg, P. D., & Hardingham, T. E. (2009). The influence of donor and hypoxic conditions on the assembly of cartilage matrix by osteoarthritic human articular chondrocytes on Hyalograft matrices. BIOMATERIALS, 30(4), 535-540. doi:10.1016/j.biomaterials.2008.09.064

DOI: 10.1016/j.biomaterials.2008.09.064
: Journal article

Rapid stimulation of p38 MAPK and upregulation of SOX9 mRNA following hyperosmotic treatment of human articular chondrocytes

Tew, S. R., Hardingham, T. E., & Clegg, P. D. (2009). Rapid stimulation of p38 MAPK and upregulation of SOX9 mRNA following hyperosmotic treatment of human articular chondrocytes. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 90 (pp. A132). Retrieved from https://www.webofscience.com/

: Conference Paper

2008

SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcription

Tew, S. R., Pothacharoen, P., Katopod, T., & Hardingham, T. E. (2008). SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcription. BIOCHEMICAL JOURNAL, 414, 231-236. doi:10.1042/BJ20080262

DOI: 10.1042/BJ20080262
: Journal article

Human infrapatellar fat pad-derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2

Khan, W. S., Tew, S. R., Adesida, A. B., & Hardingham, T. E. (2008). Human infrapatellar fat pad-derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2. ARTHRITIS RESEARCH & THERAPY, 10(4). doi:10.1186/ar2448

DOI: 10.1186/ar2448
: Journal article

BSMB Autumn 2007 meeting report - Shaping and sensing the extracellular matrix

Kuiper, N., Gabriel, N., Griffiths, S., & Tew, S. (2008). BSMB Autumn 2007 meeting report - Shaping and sensing the extracellular matrix. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 89(3), A1-A4. doi:10.1111/j.1365-2613.2007.00572.x

DOI: 10.1111/j.1365-2613.2007.00572.x
: Journal article

Cellular methods in cartilage research: Primary human chondrocytes in culture and chondrogenesis in human bone marrow stem cells

Tew, S. R., Murdoch, A. D., Rauchenberg, R. P., & Hardingham, T. E. (2008). Cellular methods in cartilage research: Primary human chondrocytes in culture and chondrogenesis in human bone marrow stem cells. METHODS, 45(1), 2-9. doi:10.1016/j.ymeth.2008.01.006

DOI: 10.1016/j.ymeth.2008.01.006
: Journal article

Notch signaling through jagged-1 is necessary to initiate chondrogenesis in human bone marrow stromal cells but must be switched off to complete chondrogenesis

Oldershaw, R. A., Tew, S. R., Russell, A. M., Meade, K., Hawkins, R., McKay, T. R., . . . Hardingham, T. E. (2008). Notch signaling through jagged-1 is necessary to initiate chondrogenesis in human bone marrow stromal cells but must be switched off to complete chondrogenesis. STEM CELLS, 26(3), 666-674. doi:10.1634/stemcells.2007-0806

DOI: 10.1634/stemcells.2007-0806
: Journal article

Bone marrow derived mesenchymal stem cells express pericyte markers in culture and show enhanced chondrogenesis in hypoxic conditions

Khan, W. S., Adesida, A. B., Tew, S. R., Andrew, J. G., & Hardingham, T. E. (2008). Bone marrow derived mesenchymal stem cells express pericyte markers in culture and show enhanced chondrogenesis in hypoxic conditions. In CALCIFIED TISSUE INTERNATIONAL Vol. 83 (pp. 17). Retrieved from https://www.webofscience.com/

: Conference Paper

Osmotic regulation of SOX9 in human articular chondrocytes through p38 MAPK mediated mRNA stabilization

Tew, S. R., Mckay, T., Lowe, E., Clegg, P. D., & Hardingham, T. E. (2008). Osmotic regulation of SOX9 in human articular chondrocytes through p38 MAPK mediated mRNA stabilization. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 89 (pp. A26). Retrieved from https://www.webofscience.com/

: Conference Paper

Vascular pericytes in human infrapatellar fat pad tissue are candidate adult stem cells

Khan, W. S., Tew, S. R., Adesida, A. B., & Hardingham, T. E. (2008). Vascular pericytes in human infrapatellar fat pad tissue are candidate adult stem cells. Arthritis Res Ther, 10, R74.

: Journal article

2007

SOX9 transduction of a human chondrocytic cell line identifies novel genes regulated in primary human chondrocytes and in osteoarthritis

Tew, S. R., Clegg, P. D., Brew, C. J., Redmond, C. M., & Hardingham, T. E. (2007). SOX9 transduction of a human chondrocytic cell line identifies novel genes regulated in primary human chondrocytes and in osteoarthritis. ARTHRITIS RESEARCH & THERAPY, 9(5). doi:10.1186/ar2311

DOI: 10.1186/ar2311
: Journal article

Cell Culture in Tissue Engineering

Hardingham, T. E., Kielty, C. M., Canfield, A. E., Tew, S. R., Ball, S. G., Turner, N. J., & Ratcliffe, K. E. (2007). Cell Culture in Tissue Engineering. In Unknown Book (pp. 523-541). Wiley. doi:10.1002/9780470723791.ch28

DOI: 10.1002/9780470723791.ch28
: Chapter

Tissue regeneration: Formation and repair of the extracellular matrix

Hardingham, T., Tew, S., & Murdoch, A. (2007). Tissue regeneration: Formation and repair of the extracellular matrix. The Biochemist, 29(1), 16-18. doi:10.1042/bio02901016

DOI: 10.1042/bio02901016
: Journal article

Cell culture in tissue engineering

Hardingham, T. E., Kielty, C. M., Canfield, A. E., Tew, S. R., Ball, S. G., Turner, N. J., & Ratcliffe, K. E. (2007). Cell culture in tissue engineering. In G. Stacey, & J. Davis (Eds.), Biological Medicines from Cell Culture (pp. 525-543). London: John Wiley and Sons.

: Chapter

In situ detection of cell death in articular cartilage.

Redman, S. N., Khan, I. M., Tew, S. R., & Archer, C. W. (2007). In situ detection of cell death in articular cartilage.. Methods in molecular medicine, 135, 183-199. doi:10.1007/978-1-59745-401-8_11

DOI: 10.1007/978-1-59745-401-8_11
: Journal article

Interleukin 1β activation of p38 MAPK in human osteoarthritic articular chondrocytes increases SOX9 expression and is dependent on cytoskeletal organisation

Tew, S. R., & Hardingham, T. E. (2007). Interleukin 1β activation of p38 MAPK in human osteoarthritic articular chondrocytes increases SOX9 expression and is dependent on cytoskeletal organisation. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 88 (pp. A53-A54). Retrieved from https://www.webofscience.com/

: Conference Paper

2006

Regulation of SOX9 mRNA in human articular chondrocytes involving p38 MAPK activation and mRNA stabilization

Tew, S. R., & Hardingham, T. E. (2006). Regulation of SOX9 mRNA in human articular chondrocytes involving p38 MAPK activation and mRNA stabilization. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(51), 39471-39479. doi:10.1074/jbc.M604322200

DOI: 10.1074/jbc.M604322200
: Journal article

Cartilage, SOX9 and notch signals in chondrogenesis

Hardingham, T. E., Oldershaw, R. A., & Tew, S. R. (2006). Cartilage, SOX9 and notch signals in chondrogenesis. JOURNAL OF ANATOMY, 209(4), 469-480. doi:10.1111/j.1469-7580.2006.00630.x

DOI: 10.1111/j.1469-7580.2006.00630.x
: Journal article

Control of chondrogenesis and the assembly of cartilage matrix

Hardingham, T., Tew, S., Oldershaw, R., & Murdoch, A. (2006). Control of chondrogenesis and the assembly of cartilage matrix. In JOURNAL OF ANATOMY Vol. 209 (pp. 573). Retrieved from https://www.webofscience.com/

: Conference Paper

SOX9 can be superinduced by cycloheximide during the early stages of human articular chondrocyte redifferentiation by a p38 MAPK-dependent mechanism

Tew, S. R., & Hardingham, T. E. (2006). SOX9 can be superinduced by cycloheximide during the early stages of human articular chondrocyte redifferentiation by a p38 MAPK-dependent mechanism. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 87 (pp. A54-A55). Retrieved from https://www.webofscience.com/

: Conference Paper

2005

Co-expression of SOX 9 and SOX 6 enhances collagen 2 gene expression

Lunj, S., Duxbury, R., Russell, A. M., Li, Y., Tew, S. R., Hardingham, T. E., . . . Hawkins, R. E. (2005). Co-expression of SOX 9 and SOX 6 enhances collagen 2 gene expression. European Cells and Materials, 10(SUPPL.2), 52.

: Journal article

British Society for Matrix Biology Autumn Meeting  Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UK

British Society for Matrix Biology Autumn Meeting  Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UK (2005). In International Journal of Experimental Pathology Vol. 86. Wiley. doi:10.1111/j.0959-9673.2005.00426.x

DOI: 10.1111/j.0959-9673.2005.00426.x
: Conference Paper

Microarray analysis of SOX9-transduced chondrocytic cells identifies genes that are regulated in osteoarthritis

Tew, S. R., Clegg, P. D., Brew, C. J., & Hardingham, T. E. (2005). Microarray analysis of SOX9-transduced chondrocytic cells identifies genes that are regulated in osteoarthritis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 86 (pp. A86-A87). Retrieved from https://www.webofscience.com/

: Conference Paper

Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes

Tew, S. R., Li, Y., Pothacharoen, P., Tweats, L. M., Hawkins, R. E., & Hardingham, T. E. (2005). Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes. OSTEOARTHRITIS AND CARTILAGE, 13(1), 80-89. doi:10.1016/j.joca.2004.10.011

DOI: 10.1016/j.joca.2004.10.011
: Journal article

Stimulation of cartilage matrix synthesis by human articular chondrocytes using SOX9 transfection and hypoxic culture conditions

Tew, S. R., Li, Y., Tweats, L. M., Hawkins, R. E., & Hardingham, T. E. (2005). Stimulation of cartilage matrix synthesis by human articular chondrocytes using SOX9 transfection and hypoxic culture conditions. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 86 (pp. A5-A6). Retrieved from https://www.webofscience.com/

: Conference Paper

2004

Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9

Li, Y., Tew, S. R., Russell, A. M., Gonzalez, K. R., Hardingham, T. E., & Hawkins, R. E. (2004). Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9. TISSUE ENGINEERING, 10(3-4), 575-584. doi:10.1089/107632704323061933

DOI: 10.1089/107632704323061933
: Journal article

Transduction of human articular chondrocytes with adenoviral, retroviral and lentiviral vectors and the effects of enhanced expression of SOX9

Li, Y., Tew, S. R., Russell, A. M., Gonzalez, K., Hardingham, T. E., & Hawkins, R. E. (2004). Transduction of human articular chondrocytes with adenoviral, retroviral and lentiviral vectors and the effects of enhanced expression of SOX9. Tissue Engineering, 10, 375-384.

: Journal article

2003

SOX9 transduction and TGFβ-3 treatment of late passage human articular chondrocytes in pellet culture potentiates cartilage matrix formation

Tew, S. R., Li, Y., Tweats, L. M., Katopodi, T., Hawkins, R. E., & Hardingham, T. E. (2003). SOX9 transduction and TGFβ-3 treatment of late passage human articular chondrocytes in pellet culture potentiates cartilage matrix formation. In European Cells and Materials Vol. 6 (pp. 53).

: Conference Paper

2002

Efficient transduction of human chondrocytes with retroviral, lentiviral and adenoviral vectors

Li, Y., Russell, A. M., Tew, S. R., Hardingham, T. E., & Hawkins, R. E. (2002). Efficient transduction of human chondrocytes with retroviral, lentiviral and adenoviral vectors. In Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products (pp. 103).

: Conference Paper

Enhanced chondrocyte redifferentiation after SOX9 transduction

Tew, S. R., Li, Y., Russell, A., Prince, J. M., Hawkins, R., & Hardingham, T. E. (2002). Enhanced chondrocyte redifferentiation after SOX9 transduction. In Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products (pp. 48).

: Conference Paper

The re-expression of chondrocytic phenotype by passaged human articular chondrocytes is improved by viral transduction of SOX9

Tew, S. R., Li, Y., Russell, A. M., Prince, J. M., Hawkins, R. E., & Hardingham, T. E. (2002). The re-expression of chondrocytic phenotype by passaged human articular chondrocytes is improved by viral transduction of SOX9. In European Cells and Materials Vol. 4 (pp. 88).

: Conference Paper

Tissue engineering: chondrocytes and cartilage

Hardingham, T., Tew, S., & Murdoch, A. (2002). Tissue engineering: chondrocytes and cartilage. ARTHRITIS RESEARCH & THERAPY, 4, S63-S68. doi:10.1186/ar561

DOI: 10.1186/ar561
: Journal article

2001

SOX gene expression and growth factor responses of human chondrocyte cell lines in monolayer culture

Tew, S. R., Goldring, M. B., & Hardingham, T. E. (2001). SOX gene expression and growth factor responses of human chondrocyte cell lines in monolayer culture. In International Journal of Experimental Pathology Vol. 82.

: Conference Paper

Differences in repair responses between immature and mature cartilage

Tew, S., Redman, S., Kwan, A., Walker, E., Khan, I., Dowthwaite, G., . . . Archer, C. W. (2001). Differences in repair responses between immature and mature cartilage. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, (391), S142-S152. Retrieved from https://www.webofscience.com/

: Journal article

2000

The reactions of articular cartilage to experimental wounding - Role of apoptosis

Tew, S. R., Kwan, A. P. L., Hann, A., Thomson, B. M., & Archer, C. W. (2000). The reactions of articular cartilage to experimental wounding - Role of apoptosis. ARTHRITIS AND RHEUMATISM, 43(1), 215-225. doi:3.0.CO;2-X">10.1002/1529-0131(200001)43:1<215::AID-ANR26>3.0.CO;2-X

DOI: 10.1002/1529-0131(200001)43:1<215::AID-ANR26>3.0.CO;2-X
: Journal article

The reactions of articular cartilage to experimental wounding: role of apoptosis.

Tew, S. R., Kwan, A. P., Hann, A., Thomson, B. M., & Archer, C. W. (2000). The reactions of articular cartilage to experimental wounding: role of apoptosis.. Arthritis and rheumatism, 43(1), 215-225. doi:3.0.co;2-x">10.1002/1529-0131(200001)43:1<215::aid-anr26>3.0.co;2-x

DOI: 10.1002/1529-0131(200001)43:1<215::aid-anr26>3.0.co;2-x
: Journal article

1998

What can we learn about cartilage repair from development?

Archer, C. W., Francis-West, P., Walker, E. A., & Tew, S. R. (1998). What can we learn about cartilage repair from development?. In SKELETAL GROWTH AND DEVELOPMENT: CLINICAL ISSUES AND BASIC SCIENCE ADVANCES (pp. 491-504). Retrieved from https://www.webofscience.com/

: Conference Paper

What can we learn about cartilage repair from development?

Archer, C. W., Francis-West, P., Walker, E. A., & Tew, S. R. (1998). What can we learn about cartilage repair from development?. In J. A. Buckwalter, M. G. Ehrlich, L. J. Sandell, & S. B. Trippel (Eds.), Skeletal Growth and Development (pp. 1-2). Rosemont, IL: American Academy of Orthopaedic Surgeons.

: Chapter