Research
Detection, prevention and treatment of retinal diseases
My research interests are focussed on the early detection and medical management of retinal diseases particularly in relation to diabetic retinopathy and age-related macular degeneration. I lead research programmes in screening and grading, treatment development, imaging, clinical trials and techniques for the assessment of retinal structure and function. I have applied my research experience to the study of the eye in cerebral malaria.
With colleagues in the Department of Eye and Vision Science I am developing internal and external collaborations in laboratory studies including segmentation and analysis algortims for image analysis of retinal images and the biology of retinal vascular cells.
Research groups
Research grants
Malarial Retinopathy Screening System for Improved Diagnosis of Cerebral Malaria (VisionQuest Phase3 )
NATIONAL INSTITUTES OF HEALTH (USA)
April 2022 - March 2023
Liverpool Digital Platform for Eye Data
LIVERPOOL UNIVERSITY HOSPITALS NHS FOUNDATION TRUST (UK)
July 2023 - September 2026
Predicting Acute and Post-Recovery Outcomes in Cerebral Malaria by Optical Coherence Tomography
WELLCOME TRUST (UK)
April 2022 - March 2026
Developing implementation of ISDR variable-interval risk-based screening for diabetic retinopathy - external validation, implementation protocols and failsafe systems
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
July 2020 - December 2021
Quantifying and characterising the impact of diabetic retinophathy in the UK biobank cohort (Biobank reading centre)
QUEEN'S UNIVERSITY BELFAST (UK)
November 2016 - December 2020
Reading Centre, VICI
QUEEN'S UNIVERSITY BELFAST (UK)
January 2017 - March 2019
studentship 1058475037
KING SAUD UNIVERSITY (SAUDI ARABIA)
October 2018 - March 2023
The Relationship Between Diabetic Neuropathy and Diabetic Retinopathy in a Large Population-Based Study in Liverpool: A Focus on the Under Diagnosis of Diabetic Neuropathy
LCCG - LIVERPOOL CLINICAL COMMISSIONING GROUP (UK)
January 2019 - October 2019
Introducing personalised risk based intervals in screening for diabetic retinopathy: development, implementation and assessment of safety, cost-effectiveness and patient experience.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
April 2016 - March 2017
Individualised screening for diabetic retinopathy (ISDR) cohort study
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
December 2016 - April 2020
Malarial retinopathy screening system for improved diagnosis of cerebral malaria
NATIONAL INSTITUTES OF HEALTH (USA)
June 2014 - May 2016
OCT in Africa Phase 1
UNIVERSITY OF LEICESTER (UK)
January 2016 - June 2017
Clinical Development of an Ultrasensitive OCT Device to Improve the Management of Eye Disease
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
November 2017 - July 2022
Clinical Efficacy and Mechanistic Evaluation of Aflibercept for Proliferative Diabetic Retinopathy Clinical Efficacy and Mechanistic Evaluation of Aflibercept for Proliferative Diabetic Retinopathy A Multicentre Phase llb Randomised Active-Controlled Clinical Trial (CLARITY Reading Centre)
QUEEN'S UNIVERSITY BELFAST (UK)
August 2014 - June 2018
Defining Post Ebola Virus Disease Ophthalmic Sequelae and Opportunities for Intervention
BAYER CORPORATION (USA)
August 2016 - December 2018
A virtual trial of follow up in the community setting versus hospital eye clinics in patients with neovascular age-related macular degeneration (nAMD) treated with drugs targeting vascular endothelial growth factor (anti-VEGF drugs) (ECHoES)
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
January 2013 - June 2014
IVAN:Five year observational follow-up of the IVAN trial cohort: a study of function and morphology
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
October 2015 - February 2018
Establishing a real time data platform for whole population health research in diabetes and diabetic retinopathy
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
January 2018 - March 2018
Introducing personalised risk based intervals in screening for diabetic retinopathy: development, implementation and assessment of safety, cost-effectiveness and patient experience (ISDR study)
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
February 2013 - April 2021
EUROCONDOR
EUROPEAN COMMISSION
March 2012 - June 2016
Transplantation of IPE beneath the neuroretina in ARMD.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
September 2003 - August 2006
Regulation of proteolysis in the retinal pigment epithelium of the eye and its significance for age-related macular degeneration
FOUNDATION FOR THE PREVENTION OF BLINDNESS (UK), ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)
December 2009 - November 2014
The Retinal Microvasculature in Cerebral Malaria in African Children
WELLCOME TRUST (UK)
January 2011 - May 2015
Discriminant Function Analysis for Longitudinal Data: Applications in Medical Research (DiALog)
MEDICAL RESEARCH COUNCIL
October 2014 - September 2017
A Multicentre Prospective Phase III double-masked Randomised Controlled Non-Inferiority Trial comparing the relative clinical efficacy and cost-effectiveness of intravitreal therapy with bevacizumab (Avastin) vs ranibizumab (Lucentis) vs aflibercept (Eylea) for Central Retinal Vein Occlusion (CRVO). [LEAVO]
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
October 2014 - September 2019
Early Detection in Macular Disease (EDiMaD)
DUNHILL MEDICAL TRUST (UK)
October 2013 - March 2017
Ultrasensitive OCT Imaging for Eye Disease
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
February 2015 - January 2019
Development of effective algorithms of deblurring fundus images for improving diagnosis and management of retinal disease
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
February 2010 - January 2013
Living with age-related macular degeneration treatment
MACULAR DISEASE SOCIETY (UK)
October 2010 - May 2012
Sleep Mask pilot production capability development, and safety trials of a home based treatment and monitoring model as a primary care intervention for Diabetic Retinopathy and Wet Age-Related Macular Degeneration.
INNOVATE UK (UK)
July 2012 - July 2015
Research collaborations
Prof Robert Heyderman
collaboration in retinal microvasculature in cerebral malaria in african children with Malawi-Liverpool-Wellcome Clinical Research Programme
Prof Juan Grunwald
University of Pennsylvania
collaboration on blood flow in retinal disease
Prof Marilyn James
University of Nottingham
health economics in screening for diabetic retinopathy
Prof Mark Gabbay
Development of programme grant in screening for diabetic retinopathy
Dr Frans Coenen
trend mining in large datasets in diabetic retinopathy
Prof Alister Craig
Host parasite interactions in cerebral malaria
Prof Charles Riva
Universita di Bologna
Studies of ocular blood flow in neurovascular and retinal disease
Prof David Wong
Hong Kong University
Development of joint projects in diabetic retinopathy, age-related macular degeneration, animal research, cell biology, clinical research, epidemiology
Prof Benedetto Falsini
Università Cattolica del Sacro Cuore
electrophysiology of the eye in cerebral malaria
Dr Richard White
Walton Centre for Neurology and Neurosurgery NHS Trust
optic nerve head blood flow in intracranial hypertension and neurovascular diseases
Dr Benno Petrig
University of Indiana, Bloomington, Indiana, US
Ocular blood flow in neurovascular and retinal disease
Prof Asoke Nandi
image analysis in diabetic retinopathy
Dr Marta Garcia-Finana
statistical analysis of large datasets in age-related macular degeneration
Prof Malcolm Molyneux
the eye in cerebral malaria
Prof Barnaby Reeves
University of Bristol
Verteporfin Cohort Study and IVAN study - two large multicentre HTA funded clinical trials
Prof Usha Chakravarthy
University of Belfast
verteporfin cohort study, IVAN study, two large HTA funded clinical trials
Prof TerrieTaylor
Michigan State University
eye in cerebral malaria