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Paul McNamara

Professor Paul McNamara
MBBS MRCPCH PhD

Professor in Child Health, Honorary Consultant in Paediatric Respiratory Medicine
Women's & Children's Health

Research

Research Interest 1

Bronchiolitis
Cystic Fibrosis
Aspiration lung disease in children
Paediatric Infectious Disease
Asthma

Research grants

A study to determine the feasibility of undertaking a trial on the use of non-invasive ventilation in the management of infants with bronchiolitis - NOVEMBR

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

February 2016 - September 2018

The efficacy and mechanism of surfactant therapy in infants with life threatening Bronchiolitis: the Bronchiolitis Endotracheal Surfactant Study (BESS).

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

February 2018 - December 2025

The effect of Gastro-oesophageal reflux on CF lung disease

VERTEX PHARMACEUTICALS INC (USA)

June 2017 - August 2021

Bench Fees - Jamilah Obaid L Alshammari

ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)

October 2016 - September 2019

Prophylactic antibiotics to prevent recurrent lower respiratory tract infections in children with neurological impairment (Parrot)

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

March 2019 - February 2024

Supporting translational research in Paediatric Rheumatology and Respiratory

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

March 2016 - April 2024

The Cystic Fibrosis (CF) Anti-Staphylococcal Antibiotic Prophylaxis Trial (CF-START)

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

July 2016 - July 2028

Clinical fellows post in paediatric endocrinology

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

September 2015 - August 2017

MICA: Towards using historical data for research prioritisation in children

MEDICAL RESEARCH COUNCIL

March 2015 - February 2018

Investigating the potential of Nrf2 induction in airway epithelial cells as a treatment for RSV bronchiolitis

BRITISH SOCIETY FOR ANTIMICROBIAL CHEMOTHERAPY (UK)

August 2013 - December 2014

The role of mucus production in paediatric respiratory disease.

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

October 2010 - September 2011

A novel vaccine candidate against pneumococcal infection in children

ACTION MEDICAL RESEARCH (UK)

November 2010 - November 2012

Investigating the role of BAFF in paediatric respiratory disease

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

July 2013 - June 2015

The role of Interleukin-9-mediated mucin production in the pathogenesis of viral and bacterial respiratory disease in children.

WELLCOME TRUST (UK)

August 2005 - March 2010

The effect of pepsin and bile acids on the respiratory epithelium

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

October 2012 - September 2015

Investigation of the pro and anti-inflammatory effects of neutrophils in RSV bronchiolitis

WELLCOME TRUST (UK)

April 2013 - March 2015

Application of nanomedicine to childhood diseases.

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

October 2013 - September 2016

UK Influenza Rapid Response Influenza Clinical Network (UK-Flu Response)

WELLCOME TRUST (UK)

November 2009 - July 2011

Pepsin as a marker of aspiration in children with cerebral palsy

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

March 2011 - August 2012

The optimisation of a technique for accurately measuring pepsin and bile acids in respiratory secretions

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

December 2012 - August 2013

A pilot study to assess whethr humidified oxygen is more effective than standard oxygen therapy in treating children with acute severe asthma

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

November 2013 - October 2016

    Research collaborations

    Prof Chris Sanderson

    Investigating the role of NRF2 induction in RSV disease.

    Prof Rob Beynon

    Development of assay to measure pepsin and bile acids in respiratory secretions as a marker of reflux aspiration. Also using proteomic methods to understand which proteins in airway epithelium are ubiquitinylated in response to RSV infection.

    Dr Ray Pickles

    University of North Carolina at Chapel Hill

    Development of joint application to NIH on pathogenesis of RSV disease.

    Ass. Prof Nikki Johnson

    University of Wisconsin

    Development of Pepsin ELISA

    Prof Richard Hegele

    University of Toronto, Canada

    Sharing samples

    Dr Craig Winstanley

    Collaboration on inflammatory responses to WT and LES PsAs in airway epithelial cells

    Prof Bernie Carter

    University of Central Lancashire

    Development of bronchiolitis scoring instrument

    Dr Qibo Zhang

    Ongoing collaboration on immunological responses to normal bacterial flora in the oropharynx

    Prof Jeff Pearson & Dr Chris Ward

    University of Newcastle upon Tyne

    Co-applicants on grant to Sparks

    Prof David Thornton

    The University of Manchester

    Pulmonary Mucin production

    Assoc. Prof Steve Stick

    Princess Margaret Hospital, Perth, Australia

    Collaboration investigating the mechanisms underlying the development of asthma in children

    Dr Kevin Southern

    Investigation into the importance of IL-9 production in Cystic Fibrosis

    Dr Brian Flanagan

    Investigation into the immunopathogenesis of RSV disease