Research
Research Interest 1
Bronchiolitis
Cystic Fibrosis
Aspiration lung disease in children
Paediatric Infectious Disease
Asthma
Research groups
Research grants
A study to determine the feasibility of undertaking a trial on the use of non-invasive ventilation in the management of infants with bronchiolitis - NOVEMBR
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
February 2016 - September 2018
The efficacy and mechanism of surfactant therapy in infants with life threatening Bronchiolitis: the Bronchiolitis Endotracheal Surfactant Study (BESS).
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
February 2018 - December 2025
The effect of Gastro-oesophageal reflux on CF lung disease
VERTEX PHARMACEUTICALS INC (USA)
June 2017 - August 2021
Bench Fees - Jamilah Obaid L Alshammari
ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)
October 2016 - September 2019
Prophylactic antibiotics to prevent recurrent lower respiratory tract infections in children with neurological impairment (Parrot)
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
March 2019 - February 2024
Supporting translational research in Paediatric Rheumatology and Respiratory
ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)
March 2016 - April 2024
The Cystic Fibrosis (CF) Anti-Staphylococcal Antibiotic Prophylaxis Trial (CF-START)
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
July 2016 - July 2028
Clinical fellows post in paediatric endocrinology
ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)
September 2015 - August 2017
MICA: Towards using historical data for research prioritisation in children
MEDICAL RESEARCH COUNCIL
March 2015 - February 2018
Investigating the potential of Nrf2 induction in airway epithelial cells as a treatment for RSV bronchiolitis
BRITISH SOCIETY FOR ANTIMICROBIAL CHEMOTHERAPY (UK)
August 2013 - December 2014
The role of mucus production in paediatric respiratory disease.
ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)
October 2010 - September 2011
A novel vaccine candidate against pneumococcal infection in children
ACTION MEDICAL RESEARCH (UK)
November 2010 - November 2012
Investigating the role of BAFF in paediatric respiratory disease
ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)
July 2013 - June 2015
The role of Interleukin-9-mediated mucin production in the pathogenesis of viral and bacterial respiratory disease in children.
WELLCOME TRUST (UK)
August 2005 - March 2010
The effect of pepsin and bile acids on the respiratory epithelium
ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)
October 2012 - September 2015
Investigation of the pro and anti-inflammatory effects of neutrophils in RSV bronchiolitis
WELLCOME TRUST (UK)
April 2013 - March 2015
Application of nanomedicine to childhood diseases.
ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)
October 2013 - September 2016
UK Influenza Rapid Response Influenza Clinical Network (UK-Flu Response)
WELLCOME TRUST (UK)
November 2009 - July 2011
Pepsin as a marker of aspiration in children with cerebral palsy
ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)
March 2011 - August 2012
The optimisation of a technique for accurately measuring pepsin and bile acids in respiratory secretions
ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)
December 2012 - August 2013
A pilot study to assess whethr humidified oxygen is more effective than standard oxygen therapy in treating children with acute severe asthma
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
November 2013 - October 2016
Research collaborations
Prof Chris Sanderson
Investigating the role of NRF2 induction in RSV disease.
Prof Rob Beynon
Development of assay to measure pepsin and bile acids in respiratory secretions as a marker of reflux aspiration. Also using proteomic methods to understand which proteins in airway epithelium are ubiquitinylated in response to RSV infection.
Dr Ray Pickles
University of North Carolina at Chapel Hill
Development of joint application to NIH on pathogenesis of RSV disease.
Ass. Prof Nikki Johnson
University of Wisconsin
Development of Pepsin ELISA
Prof Richard Hegele
University of Toronto, Canada
Sharing samples
Dr Craig Winstanley
Collaboration on inflammatory responses to WT and LES PsAs in airway epithelial cells
Prof Bernie Carter
University of Central Lancashire
Development of bronchiolitis scoring instrument
Dr Qibo Zhang
Ongoing collaboration on immunological responses to normal bacterial flora in the oropharynx
Prof Jeff Pearson & Dr Chris Ward
University of Newcastle upon Tyne
Co-applicants on grant to Sparks
Prof David Thornton
The University of Manchester
Pulmonary Mucin production
Assoc. Prof Steve Stick
Princess Margaret Hospital, Perth, Australia
Collaboration investigating the mechanisms underlying the development of asthma in children
Dr Kevin Southern
Investigation into the importance of IL-9 production in Cystic Fibrosis
Dr Brian Flanagan
Investigation into the immunopathogenesis of RSV disease