Publications
Selected publications
- Influence of highly effective modulator therapy on the sputum proteome in cystic fibrosis. (Journal article - 2024)
- Measuring the effect of elexacaftor/tezacaftor/ivacaftor combination therapy on the respiratory pump in people with CF using dynamic chest radiography (Journal article - 2022)
- The relationship between lung disease severity and the sputum proteome in cystic fibrosis (Journal article - 2022)
- Use of Dynamic Chest Radiography to Assess Treatment of Pulmonary Exacerbations in Cystic Fibrosis. (Journal article - 2022)
- Which outcomes should be used in future bronchiolitis trials? Developing a bronchiolitis core outcome set using a systematic review, Delphi survey and a consensus workshop (Journal article - 2022)
- Treating nontuberculous mycobacteria in children with cystic fibrosis: a multicentre retrospective study (Journal article - 2022)
- Hypertonic saline induces inflammation in human macrophages through the NLRP1 inflammasome. (Journal article - 2023)
- Age differential CD13 and interferon expression in airway epithelia affect SARS-CoV-2 infection - effects of vitamin D. (Journal article - 2023)
- Humidified and standard oxygen therapy in acute severe asthma in children (HUMOX): A pilot randomised controlled trial. (Journal article - 2022)
- Feasibility of dynamic chest radiography to calculate lung volumes in adult people with cystic fibrosis: a pilot study (Journal article - 2023)
2024
Influence of highly effective modulator therapy on the sputum proteome in cystic fibrosis.
Maher, R. E., Barry, P. J., Emmott, E., Jones, A. M., Lin, L., McNamara, P. S., . . . Lord, R. W. (2024). Influence of highly effective modulator therapy on the sputum proteome in cystic fibrosis.. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 23(2), 269-277. doi:10.1016/j.jcf.2023.10.019
Respiratory Syncytial Virus Maternal Vaccination in Infants below 6 Months of Age: Meta-Analysis of Safety, Immunogenicity, and Efficacy.
Mapindra, M. P., Mahindra, M. P., McNamara, P., Semple, M. G., Clark, H., & Madsen, J. (2024). Respiratory Syncytial Virus Maternal Vaccination in Infants below 6 Months of Age: Meta-Analysis of Safety, Immunogenicity, and Efficacy.. Neonatology, 121(3), 271-282. doi:10.1159/000536031
Stakeholders' perspectives on clinical trial acceptability and approach to consent within a limited timeframe: a mixed methods study.
Deja, E., Donohue, C., Semple, M. G., Woolfall, K., & BESS Investigators. (2024). Stakeholders' perspectives on clinical trial acceptability and approach to consent within a limited timeframe: a mixed methods study.. BMJ open, 14(1), e077023. doi:10.1136/bmjopen-2023-077023
2023
Investigating markers of pulmonary aspiration in bronchoalveolar lavage from children with severe neurodisability
Hypertonic saline induces inflammation in human macrophages through the NLRP1 inflammasome.
Sposito, F., Northey, S., Charras, A., McNamara, P. S., & Hedrich, C. M. (2023). Hypertonic saline induces inflammation in human macrophages through the NLRP1 inflammasome.. Genes and immunity. doi:10.1038/s41435-023-00218-7
Age differential CD13 and interferon expression in airway epithelia affect SARS-CoV-2 infection - effects of vitamin D.
Sposito, F., Pennington, S. H., A W David, C., Duggan, J., Northey, S., Biagini, G., . . . Hedrich, C. M. (2023). Age differential CD13 and interferon expression in airway epithelia affect SARS-CoV-2 infection - effects of vitamin D.. Mucosal immunology, S1933-0219(23)00064-8. doi:10.1016/j.mucimm.2023.08.002
Surveillance towards preventing paediatric incidence of respiratory syncytial virus attributable respiratory tract infection in primary and secondary/tertiary healthcare settings in Merseyside, Cheshire and Bristol, UK
Fyles, F., Hill, H., Duncan, G., Carter, E., Solorzano, C., Davies, K., . . . Collins, A. M. (2023). Surveillance towards preventing paediatric incidence of respiratory syncytial virus attributable respiratory tract infection in primary and secondary/tertiary healthcare settings in Merseyside, Cheshire and Bristol, UK. BMJ OPEN RESPIRATORY RESEARCH, 10(1). doi:10.1136/bmjresp-2022-001457
Feasibility of dynamic chest radiography to calculate lung volumes in adult people with cystic fibrosis: a pilot study
FitzMaurice, T. S., McCann, C., Nazareth, D., Hawkes, S., Shaw, M., McNamara, P. S., & Walshaw, M. (2023). Feasibility of dynamic chest radiography to calculate lung volumes in adult people with cystic fibrosis: a pilot study. BMJ OPEN RESPIRATORY RESEARCH, 10(1). doi:10.1136/bmjresp-2022-001309
Respiratory Viruses and Atypical Bacteria
McNamara, P. S., Doorn, H. R. V., Adetifa, I. M. O., & Nokes, D. J. (2024). Respiratory Viruses and Atypical Bacteria. In Manson's Tropical Diseases (pp. 254-267). Elsevier. doi:10.1016/b978-0-7020-7959-7.00025-7
2022
The relationship between lung disease severity and the sputum proteome in cystic fibrosis
Maher, R. E., Barrett, E., Beynon, R. J., Harman, V. M., Jones, A. M., McNamara, P. S., . . . Lord, R. W. (2022). The relationship between lung disease severity and the sputum proteome in cystic fibrosis. RESPIRATORY MEDICINE, 204. doi:10.1016/j.rmed.2022.107002
Treating nontuberculous mycobacteria in children with cystic fibrosis: a multicentre retrospective study
Saint, G. L., Thomas, M. F., Zainal Abidin, N., Langley, R. J., Brodlie, M., & McNamara, P. (n.d.). Treating nontuberculous mycobacteria in children with cystic fibrosis: a multicentre retrospective study. Archives of Disease in Childhood. doi:10.1136/archdischild-2021-322177
Quantitative proteomic analysis of bronchoalveolar lavage fluid in West Highland white terriers with canine idiopathic pulmonary fibrosis
Maher, R. E., Maatta, M., Beynon, R. J., Laurila, H. P., McNamara, P. S., & Rajamaki, M. M. (2022). Quantitative proteomic analysis of bronchoalveolar lavage fluid in West Highland white terriers with canine idiopathic pulmonary fibrosis. BMC VETERINARY RESEARCH, 18(1). doi:10.1186/s12917-022-03202-x
Use of Dynamic Chest Radiography to Assess Treatment of Pulmonary Exacerbations in Cystic Fibrosis.
FitzMaurice, T. S., McCann, C., Nazareth, D. S., McNamara, P. S., & Walshaw, M. J. (2022). Use of Dynamic Chest Radiography to Assess Treatment of Pulmonary Exacerbations in Cystic Fibrosis.. Radiology, 212641. doi:10.1148/radiol.212641
Which outcomes should be used in future bronchiolitis trials? Developing a bronchiolitis core outcome set using a systematic review, Delphi survey and a consensus workshop
Rosala-Hallas, A., Jones, A. P., Williamson, P. R., Bedson, E., Compton, V., Fernandes, R. M., . . . McNamara, P. S. (2022). Which outcomes should be used in future bronchiolitis trials? Developing a bronchiolitis core outcome set using a systematic review, Delphi survey and a consensus workshop. BMJ Open, 12(3), e052943. doi:10.1136/bmjopen-2021-052943
Humidified and standard oxygen therapy in acute severe asthma in children (HUMOX): A pilot randomised controlled trial.
McNamara, P. S., Clayton, D., Burchett, C., Compton, V., Peak, M., Clark, J., & Jones, A. P. (2022). Humidified and standard oxygen therapy in acute severe asthma in children (HUMOX): A pilot randomised controlled trial.. PloS one, 17(2), e0263044. doi:10.1371/journal.pone.0263044
Measuring the effect of elexacaftor/tezacaftor/ivacaftor combination therapy on the respiratory pump in people with CF using dynamic chest radiography
FitzMaurice, T. S., McCann, C., Nazareth, D., Shaw, M., McNamara, P. S., & Walshaw, M. J. (2022). Measuring the effect of elexacaftor/tezacaftor/ivacaftor combination therapy on the respiratory pump in people with CF using dynamic chest radiography. Journal of Cystic Fibrosis. doi:10.1016/j.jcf.2022.01.007
2021
160: Using dynamic chest radiography to assess response to treatment in acute pulmonary exacerbations of adult people with cystic fibrosis
FitzMaurice, T., McCann, C., Nazareth, D., Walshaw, M., & McNamara, P. (2021). 160: Using dynamic chest radiography to assess response to treatment in acute pulmonary exacerbations of adult people with cystic fibrosis. Journal of Cystic Fibrosis, 20, S79. doi:10.1016/s1569-1993(21)01585-x
547: Characterization of diaphragm and chest wall mechanics in people with CF using dynamic chest radiography: Initial experiences
FitzMaurice, T., McCann, C., Nazareth, D., Walshaw, M., & McNamara, P. (2021). 547: Characterization of diaphragm and chest wall mechanics in people with CF using dynamic chest radiography: Initial experiences. Journal of Cystic Fibrosis, 20, S258-S259. doi:10.1016/s1569-1993(21)01970-6
Detection of Serum Cross-Reactive Antibodies and Memory Response to SARS-CoV-2 in Prepandemic and Post-COVID-19 Convalescent Samples
Shrwani, K., Sharma, R., Krishnan, M., Jones, T., Mayora-Neto, M., Cantoni, D., . . . Zhang, Q. (2021). Detection of Serum Cross-Reactive Antibodies and Memory Response to SARS-CoV-2 in Prepandemic and Post-COVID-19 Convalescent Samples. JOURNAL OF INFECTIOUS DISEASES, 224(8), 1305-1315. doi:10.1093/infdis/jiab333
Early Life Respiratory Infection
Patel, L. B., Legg, J. P., & McNamara, P. S. (2022). Early Life Respiratory Infection. In Encyclopedia of Respiratory Medicine (pp. 110-118). Elsevier. doi:10.1016/b978-0-08-102723-3.00195-5
P102 Utility of Dynamic Chest Radiography (DCR) for calculating lung volume subdivisions in adult people with cystic fibrosis
FitzMaurice, T. S., Nazareth, D., McCann, C., Walshaw, M., & McNamara, P. S. (2021). P102 Utility of Dynamic Chest Radiography (DCR) for calculating lung volume subdivisions in adult people with cystic fibrosis. Journal of Cystic Fibrosis, 20, S70. doi:10.1016/s1569-1993(21)01128-0
2020
Vasculitis in Cystic Fibrosis
Sposito, F., McNamara, P. S., & Hedrich, C. M. (2020). Vasculitis in Cystic Fibrosis. FRONTIERS IN PEDIATRICS, 8. doi:10.3389/fped.2020.585275
National survey of feasibility of NIV trials for management of children with bronchiolitis.
Rosala-Hallas, A., Jones, A. P., Bedson, E., Compton, V., Fernandes, R. M., Lacy, D., . . . McNamara, P. S. (2020). National survey of feasibility of NIV trials for management of children with bronchiolitis.. BMJ Paediatrics Open, 4(1), e000780. doi:10.1136/bmjpo-2020-000780
Modified Vaccinia Ankara–Vectored Vaccine Expressing Nucleoprotein and Matrix Protein 1 (M1) Activates Mucosal M1-Specific T-Cell Immunity and Tissue-Resident Memory T Cells in Human Nasopharynx-Associated Lymphoid Tissue
Puksuriwong, S., Ahmed, M. S., Sharma, R., Krishnan, M., Leong, S., Lambe, T., . . . Zhang, Q. (2020). Modified Vaccinia Ankara–Vectored Vaccine Expressing Nucleoprotein and Matrix Protein 1 (M1) Activates Mucosal M1-Specific T-Cell Immunity and Tissue-Resident Memory T Cells in Human Nasopharynx-Associated Lymphoid Tissue. The Journal of infectious diseases, 222(5), 807-819. doi:10.1093/infdis/jiz593
Respiratory Syncytial Virus-related Death in Children With Down Syndrome
Löwensteyn, Y. N., Phijffer, E. W. E. M., Simons, J. V. L., Scheltema, N. M., Mazur, N. I., Nair, H., & Bont, L. J. (2020). Respiratory Syncytial Virus-related Death in Children With Down Syndrome. Pediatric Infectious Disease Journal, 39(8), 665-670. doi:10.1097/inf.0000000000002666
Pathobiology of Respiratory Syncytial Virus (RSV).
Tripp, R. A., & McNamara, P. S. (2020). Pathobiology of Respiratory Syncytial Virus (RSV).. Vaccines, 8(3). doi:10.3390/vaccines8030367
COVID-19: Immunology and treatment options
Felsenstein, S., Herbert, J. A., McNamara, P. S., & Hedrich, C. M. (2020). COVID-19: Immunology and treatment options. CLINICAL IMMUNOLOGY, 215. doi:10.1016/j.clim.2020.108448
Utility and validity of dynamic chest radiography in cystic fibrosis (dynamic CF): an observational, non-controlled, non-randomised, single-centre, prospective study.
FitzMaurice, T. S., McNamara, P. S., Nazareth, D., McCann, C., Bedi, R., Shaw, M., & Walshaw, M. (2020). Utility and validity of dynamic chest radiography in cystic fibrosis (dynamic CF): an observational, non-controlled, non-randomised, single-centre, prospective study.. BMJ Open Respir Res, 7(1). doi:10.1136/bmjresp-2020-000569
2019
Minimally Invasive Nasal Sampling in Children Offers Accurate Pneumococcal Colonization Detection
Nikolaou, E., Blizard, A., Pojar, S., Mitsi, E., German, E. L., Reine, J., . . . Jochems, S. P. (2019). Minimally Invasive Nasal Sampling in Children Offers Accurate Pneumococcal Colonization Detection. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 38(11), 1147-1149. doi:10.1097/INF.0000000000002454
Adherence to Aerosol Therapy in Young People With Cystic Fibrosis: Patient and Parent Perspectives Following Electronic Data Capture.
O'Toole, D. P. H., Latchford, G. J., Duff, A. J. A., Ball, R., McCormack, P., McNamara, P. S., . . . Southern, K. W. (2019). Adherence to Aerosol Therapy in Young People With Cystic Fibrosis: Patient and Parent Perspectives Following Electronic Data Capture. QUALITATIVE HEALTH RESEARCH, 29(6), 846-856. doi:10.1177/1049732318805754
Dynamic changes in innate immune and T cell function and composition at the nasal mucosa across the human lifespan
Reiné, J., Carniel, B., Solórzano, C., Mitsi, E., Pojar, S., Nikolaou, E., . . . Jochems, S. (2019). Dynamic changes in innate immune and T cell function and composition at the nasal mucosa across the human lifespan. doi:10.1101/576744
Epidemiology of Nontuberculous Mycobacteria Infection in Children and Young People With Cystic Fibrosis: Analysis of UK Cystic Fibrosis Registry
Gardner, A. I., McClenaghan,, E., Saint, G., Mcnamara, P. S., Brodlie, M., & Thomas, M. F. (2019). Epidemiology of Nontuberculous Mycobacteria Infection in Children and Young People With Cystic Fibrosis: Analysis of UK Cystic Fibrosis Registry. Clinical Infectious Diseases, 68(05), 731-737. doi:10.1093/cid/ciy531
Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (vol 19, pg 625, 2018)
Dunning, J., Blankley, S., Hoang, L. T., Cox, M., Graham, C. M., James, P. L., . . . Griffiths, M. J. (2019). Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (vol 19, pg 625, 2018). NATURE IMMUNOLOGY, 20(3), 373. doi:10.1038/s41590-019-0328-y
Contribution of respiratory viruses and bacteria to community-acquired pneumonia in highly vaccinated children: a case-control study.
Saint, G. L., Hawcutt, D. B., & McNamara, P. S. (2019). Contribution of respiratory viruses and bacteria to community-acquired pneumonia in highly vaccinated children: a case-control study.. Thorax. doi:10.1136/thoraxjnl-2018-212625
2018
Non-invasive ventilation for the management of children with bronchiolitis (NOVEMBR): a feasibility study and core outcome set development protocol
van Miert, C., Fernandes, R. M., Eccleson, H., Bedson, E., Lane, S., Peak, M., . . . McNamara, P. S. (2018). Non-invasive ventilation for the management of children with bronchiolitis (NOVEMBR): a feasibility study and core outcome set development protocol. TRIALS, 19. doi:10.1186/s13063-018-2969-9
Expression of the B cell differentiation factor BAFF and chemokine CXCL13 in a murine model of Respiratory Syncytial Virus infection
Alturaiki, W., McFarlane, A. J., Rose, K., Corkhill, R., McNamara, P. S., Schwarze, J., & Flanagan, B. F. (2018). Expression of the B cell differentiation factor BAFF and chemokine CXCL13 in a murine model of Respiratory Syncytial Virus infection. CYTOKINE, 110, 267-271. doi:10.1016/j.cyto.2018.01.014
Children’s views on research without prior consent in emergency situations: a UK qualitative study
Roper, L., Sherratt, F., Young, B., Mcnamara, P., Dawson, A., Appleton, R., . . . Woolfall, K. (2018). Children’s views on research without prior consent in emergency situations: aUK qualitative study. BMJ Open, 8(6). doi:10.1136/bmjopen-2018-022894
Activation and Induction of Antigen-Specific T Follicular Helper Cells Play a Critical Role in Live-Attenuated Influenza Vaccine-Induced Human Mucosal Anti-influenza Antibody Response
Aljurayyan, A., Puksuriwong, S., Ahmed, M., Sharma, R., Krishnan, M., Sood, S., . . . Zhang, Q. (2018). Activation and Induction of Antigen-Specific T Follicular Helper Cells Play a Critical Role in Live-Attenuated Influenza Vaccine-Induced Human Mucosal Anti-influenza Antibody Response. Journal of virology, 92(11). doi:10.1128/jvi.00114-18
Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza
Dunning, J., Blankley, S., Hoang, L. T., Cox, M., Graham, C. M., James, P. L., . . . Openshaw, P. J. M. (2018). Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza. Nature Immunology, 19(06), 625-635. doi:10.1038/s41590-018-0111-5
Transaminase levels reflect disease severity in children ventilated for respiratory syncytial virus (RSV) bronchiolitis
Thorburn, K., Fulton, C., King, C., Ramaneswaran, D., Alammar, A., & McNamara, P. S. (2018). Transaminase levels reflect disease severity in children ventilated for respiratory syncytial virus (RSV) bronchiolitis. SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-018-20292-6
Accumulation mode particles and LPS exposure induce TLR-4 dependent and independent inflammatory responses in the lung
Fonceca, A. M., Zosky, G. R., Bozanich, E. M., Sutanto, E. N., Kicic, A., McNamara, P. S., . . . Stick, S. M. (2018). Accumulation mode particles and LPS exposure induce TLR-4 dependent and independent inflammatory responses in the lung. RESPIRATORY RESEARCH, 19. doi:10.1186/s12931-017-0701-z
2017
Recovery of hypothalamo–pituitary–adrenal axis suppression during treatment with inhaled corticosteroids for childhood asthma
Gangadharan, A., McCoy, P., Phyo, A., McGuigan, M. P., Dharmaraj, P., Ramakrishnan, R., & McNamara, P. S. (2017). Recovery of hypothalamo–pituitary–adrenal axis suppression during treatment with inhaled corticosteroids for childhood asthma. Journal of Asthma and Allergy, 2017(10), 317-326. doi:10.2147/JAA.S142874
Novel FOXA2 mutation causes Hyperinsulinism, Hypopituitarism with Craniofacial and Endoderm-derived organ abnormalities
Giri, D., Vignola, M. L., Gualtieri, A., Scagliotti, V., McNamara, P., Peak, M., . . . Senniappan, S. (2017). Novel FOXA2 mutation causes Hyperinsulinism, Hypopituitarism with Craniofacial and Endoderm-derived organ abnormalities. HUMAN MOLECULAR GENETICS, 26(22), 4315-4326. doi:10.1093/hmg/ddx318
Novel compound heterozygous <i>ASXL3</i> mutation causing Bainbridge-ropers like syndrome and primary IGF1 deficiency
Giri, D., Rigden, D., Didi, M., Peak, M., McNamara, P., & Senniappan, S. (2017). Novel compound heterozygous <i>ASXL3</i> mutation causing Bainbridge-ropers like syndrome and primary IGF1 deficiency. INTERNATIONAL JOURNAL OF PEDIATRIC ENDOCRINOLOGY. doi:10.1186/s13633-017-0047-9
Predicting Risk of Serious Bacterial Infections in Febrile Children in the Emergency Department
Irwin, A. D., Grant, A., Williams, R., Kolamunnage-Dona, R., Drew, R. J., Paulus, S., . . . Carrol, E. D. (2017). Predicting Risk of Serious Bacterial Infections in Febrile Children in the Emergency Department. Pediatrics, 140(2), 0. doi:10.1542/peds.2016-2853
M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza
Cole, S. L., Dunning, J., Kok, W. L., Benam, K. H., Benlahrech, A., Repapi, E., . . . Ho, L. -P. (2017). M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza. JCI INSIGHT, 2(7). doi:10.1172/jci.insight.91868
2016
A critical role of T follicular helper cells in human mucosal anti-influenza response that can be enhanced by immunological adjuvant CpG-DNA
Aljurayyan, A. N., Sharma, R., Upile, N., Beer, H., Vaughan, C., Xie, C., . . . Zhang, Q. (2016). A critical role of T follicular helper cells in human mucosal anti-influenza response that can be enhanced by immunological adjuvant CpG-DNA. ANTIVIRAL RESEARCH, 132, 122-130. doi:10.1016/j.antiviral.2016.05.021
Weakly acidic pH reduces inflammatory cytokine expression in airway epithelial cells
Hackett, A. M., Trinick, R. E., Rose, K., Flanagan, B. F., & McNamara, P. S. (2016). Weakly acidic pH reduces inflammatory cytokine expression in airway epithelial cells. Respiratory Research, 17. doi:10.1186/s12931-016-0399-3
Activation of cross-reactive mucosal T and B cell responses in human nasopharynx-associated lymphoid tissue <i>in vitro</i> by Modified Vaccinia Ankara-vectored influenza vaccines
Mullin, J., Ahmed, M. S., Sharma, R., Upile, N., Beer, H., Achar, P., . . . Zhang, Q. (2016). Activation of cross-reactive mucosal T and B cell responses in human nasopharynx-associated lymphoid tissue <i>in vitro</i> by Modified Vaccinia Ankara-vectored influenza vaccines. VACCINE, 34(14), 1688-1695. doi:10.1016/j.vaccine.2016.02.028
Characterisation Of The Neutrophil In Respiratory Syncytial Virus Bronchiolitis
Saint, G. L., Smyth, R., Flanagan, B. F., & McNamara, P. S. (2016). Characterisation Of The Neutrophil In Respiratory Syncytial Virus Bronchiolitis. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 193. Retrieved from https://www.webofscience.com/
Rhinovirus-C detection in children presenting with acute respiratory infection to hospital in Brazil
Fawkner-Corbett, D. W., Khoo, S. K., Duarte, C. M., Bezerra, P. G. M., Bochkov, Y. A., Gern, J. E., . . . McNamara, P. S. (2016). Rhinovirus-C detection in children presenting with acute respiratory infection to hospital in Brazil. JOURNAL OF MEDICAL VIROLOGY, 88(1), 58-63. doi:10.1002/jmv.24300
2015
Blood eosinophils as a marker of likely corticosteroid response in children with preschool wheeze: time for an eosinophil guided clinical trial?
Gaillard, E. A., McNamara, P. S., Murray, C. S., Pavord, I. D., & Shields, M. D. (2015). Blood eosinophils as a marker of likely corticosteroid response in children with preschool wheeze: time for an eosinophil guided clinical trial?. CLINICAL AND EXPERIMENTAL ALLERGY, 45(9), 1384-1395. doi:10.1111/cea.12535
Saline in Acute Bronchiolitis RCT and Economic evaluation: hypertonic saline in acute bronchiolitis - randomised controlled trial and systematic review
Everard, M. L., Hind, D., Ugonna, K., Freeman, J., Bradburn, M., Dixon, S., . . . Cross, E. (2015). Saline in Acute Bronchiolitis RCT and Economic evaluation: hypertonic saline in acute bronchiolitis - randomised controlled trial and systematic review. HEALTH TECHNOLOGY ASSESSMENT, 19(66), 1-+. doi:10.3310/hta19660
Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus
Habibi, M. S., Jozwik, A., Makris, S., Dunning, J., Paras, A., The Mechanisms of Severe Acute Influenza Consortium Investigators., . . . Chiu, C. (2015). Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 191(9), 1040-1049. doi:10.1164/rccm.201412-2256OC
An Observational Study Examining the Relationship between Respiratory Symptoms, Airway Inflammation and Bacteriology in Children with Severe Neurodisability
Trinick, R. E., Bunni, L., Thorburn, K., Hackett, A. P., Dalzell, M., & McNamara, P. S. (2015). An Observational Study Examining the Relationship between Respiratory Symptoms, Airway Inflammation and Bacteriology in Children with Severe Neurodisability. PLOS ONE, 10(4). doi:10.1371/journal.pone.0124627
Etiology of Childhood Bacteremia and Timely Antibiotics Administration in the Emergency Department
Irwin, A., Drew, R. J., Marshall, P., Nguyen, K., Hoyle, E., Macfarlane, K. A., . . . Carrol, E. (2015). Etiology of Childhood Bacteremia and Timely Antibiotics Administration in the Emergency Department. Pediatrics, 135(4), 635-642. doi:10.1542/peds.2014-2061
Cross-reactive immunity against influenza viruses in children and adults following 2009 pandemic H1N1 infection
Ahmed, M. S., Jacques, L. C., Mahallawi, W., Ferrara, F., Temperton, N., Upile, N., . . . Zhang, Q. (2015). Cross-reactive immunity against influenza viruses in children and adults following 2009 pandemic H1N1 infection. ANTIVIRAL RESEARCH, 114, 106-112. doi:10.1016/j.antiviral.2014.12.008
2014
SABRE: a multicentre randomised control trial of nebulised hypertonic saline in infants hospitalised with acute bronchiolitis
Everard, M. L., Hind, D., Ugonna, K., Freeman, J., Bradburn, M., Cooper, C. L., . . . Team, S. A. B. R. E. S. (2014). SABRE: a multicentre randomised control trial of nebulised hypertonic saline in infants hospitalised with acute bronchiolitis. THORAX, 69(12), 1105-1112. doi:10.1136/thoraxjnl-2014-205953
Turnover of strains and intraclonal variation amongst <i>Pseudomonas aeruginosa</i> isolates from paediatric CF patients
Hall, A. J., Fothergill, J. L., McNamara, P. S., Southern, K. W., & Winstanley, C. (2014). Turnover of strains and intraclonal variation amongst <i>Pseudomonas aeruginosa</i> isolates from paediatric CF patients. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 80(4), 324-326. doi:10.1016/j.diagmicrobio.2014.09.007
Accumulation of Human-Adapting Mutations during Circulation of A(H1N1)pdm09 Influenza Virus in Humans in the United Kingdom
Elderfield, R. A., Watson, S. J., Godlee, A., Adamson, W. E., Thompson, C. I., Dunning, J., . . . Barclay, W. S. (2014). Accumulation of Human-Adapting Mutations during Circulation of A(H1N1)pdm09 Influenza Virus in Humans in the United Kingdom. JOURNAL OF VIROLOGY, 88(22), 13269-13283. doi:10.1128/JVI.01636-14
Development and validation of the Liverpool infant bronchiolitis severity score: a research protocol
van Miert, C., Abbott, J., Verheoff, F., Lane, S., Carter, B., & McNamara, P. (2014). Development and validation of the Liverpool infant bronchiolitis severity score: a research protocol. JOURNAL OF ADVANCED NURSING, 70(10), 2353-2362. doi:10.1111/jan.12387
Characterisation of acute respiratory infections at a United Kingdom paediatric teaching hospital: observational study assessing the impact of influenza A (2009 pdmH1N1) on predominant viral pathogens
Lees, E., Carrol, E., Gerrard, C., Hardiman, F., Howel, G., Timmis, A., . . . McNamara, P. (2014). Characterisation of acute respiratory infections at a United Kingdom paediatric teaching hospital: observational study assessing the impact of influenza A (2009 pdmH1N1) on predominant viral pathogens. BMC Infectious Diseases, 14. doi:10.1186/1471-2334-14-343
THE B LYMPHOCYTE DIFFERENTIATION FACTOR (BAFF) IS EXPRESSED IN THE AIRWAYS OF CHILDREN WITH CF AND IN LUNGS OF MICE INFECTED WITH PSEUDOMONAS AERUGINOSA
Neill, D. R., Saint, G. L., Bricio-Moreno, L., Fothergill, J., Southern, K. W., Winstanley, C., . . . Flanagan, B. F. (2014). THE B LYMPHOCYTE DIFFERENTIATION FACTOR (BAFF) IS EXPRESSED IN THE AIRWAYS OF CHILDREN WITH CF AND IN LUNGS OF MICE INFECTED WITH PSEUDOMONAS AERUGINOSA. PLoS One, 9(5). doi:10.1371/journal.pone.0095892.
Activation of memory Th17 cells by domain 4 pneumolysin in human nasopharynx-associated lymphoid tissue and its association with pneumococcal carriage
Gray, C., Ahmed, M. S., Mubarak, A., Kasbekar, A. V., Derbyshire, S., McCormick, M. S., . . . Zhang, Q. (2014). Activation of memory Th17 cells by domain 4 pneumolysin in human nasopharynx-associated lymphoid tissue and its association with pneumococcal carriage. MUCOSAL IMMUNOLOGY, 7(3), 705-717. doi:10.1038/mi.2013.89
Airway Expression Of The B Cell Differentiation Factor Baff And Chemokine Cxcl13 In A Murine Model Of Human Respiratory Syncytial Virus Infection
Flanagan, B., McFarlane, A., Al-Turaiki, W., Fitch, P., Slupsky, J., McNamara, P. S., & Schwarze, J. (2014). Airway Expression Of The B Cell Differentiation Factor Baff And Chemokine Cxcl13 In A Murine Model Of Human Respiratory Syncytial Virus Infection. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 189. Retrieved from https://www.webofscience.com/
Cytokine Inflammatory Responses In Children With Acute Respiratory Infections By Different Viruses And Atypical Bacteria
Bezerra, P. G. D. M., Duarte, M. M. B., McNamara, P. S., Britto, M. A. D., Rose, K., Cuevas, L. E., . . . Correia, J. D. B. (2014). Cytokine Inflammatory Responses In Children With Acute Respiratory Infections By Different Viruses And Atypical Bacteria. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 189. Retrieved from https://www.webofscience.com/
Cytokines Do Not Predict Admission Patterns Or Need For Oxygen In Infants With Respiratory Syncytial Virus
Duarte, M. M. B., McNamara, P. S., Bezerra, P. G. D. M., Britto, M. A. D., Cuevas, L. E., Rose, K., . . . Correia, J. D. B. (2014). Cytokines Do Not Predict Admission Patterns Or Need For Oxygen In Infants With Respiratory Syncytial Virus. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 189. Retrieved from https://www.webofscience.com/
2013
Respiratory Viruses and Atypical Bacteria
McNamara, P. S., & Van Doorn, H. R. (2014). Respiratory Viruses and Atypical Bacteria. In Manson's Tropical Infectious Diseases (pp. 215-224.e2). Elsevier. doi:10.1016/b978-0-7020-5101-2.00020-0
Comparison of real time diagnostic chemistries to detect <i>Pseudomonas aeruginosa</i> in respiratory samples from cystic fibrosis patients
Fothergill, J. L., Ledson, M. J., Walshaw, M. J., McNamara, P. S., Southern, K. W., & Winstanley, C. (2013). Comparison of real time diagnostic chemistries to detect <i>Pseudomonas aeruginosa</i> in respiratory samples from cystic fibrosis patients. JOURNAL OF CYSTIC FIBROSIS, 12(6), 675-681. doi:10.1016/j.jcf.2013.04.007
Adherence to nebulised therapies in adolescents with cystic fibrosis is best on week-days during school term-time
Ball, R., Southern, K. W., McCormack, P., Duff, A. J. A., Brownlee, K. G., & McNamara, P. S. (2013). Adherence to nebulised therapies in adolescents with cystic fibrosis is best on week-days during school term-time. JOURNAL OF CYSTIC FIBROSIS, 12(5), 440-444. doi:10.1016/j.jcf.2012.12.012
Infection with 2009 H1N1 Influenza Virus Primes for Immunological Memory in Human Nose-Associated Lymphoid Tissue, Offering Cross-Reactive Immunity to H1N1 and Avian H5N1 Viruses
Mahallawi, W. H., Kasbekar, A. V., McCormick, M. S., Hoschler, K., Temperton, N., Leong, S. C., . . . Zhang, Q. (2013). Infection with 2009 H1N1 Influenza Virus Primes for Immunological Memory in Human Nose-Associated Lymphoid Tissue, Offering Cross-Reactive Immunity to H1N1 and Avian H5N1 Viruses. JOURNAL OF VIROLOGY, 87(10), 5331-5339. doi:10.1128/JVI.03547-12
Infection with 2009 H1N1 influenza virus primes for immunological memory in human nose-associated lymphoid tissue, offering cross-reactive immunity to H1N1 and avian H5N1 viruses.
Mahallawi, W. H., Kasbekar, A. V., McCormick, M. S., Hoschler, K., Temperton, N., Leong, S. C., . . . Zhang, Q. (2013). Infection with 2009 H1N1 influenza virus primes for immunological memory in human nose-associated lymphoid tissue, offering cross-reactive immunity to H1N1 and avian H5N1 viruses.. Journal of virology, 87(10), 5331-5339. doi:10.1128/jvi.03547-12
Intraclonal genetic diversity amongst cystic fibrosis and keratitis isolates of <i>Pseudomonas aeruginosa</i>
Hall, A. J., Fothergill, J. L., Kaye, S. B., Neal, T. J., McNamara, P. S., Southern, K. W., & Winstanley, C. (2013). Intraclonal genetic diversity amongst cystic fibrosis and keratitis isolates of <i>Pseudomonas aeruginosa</i>. JOURNAL OF MEDICAL MICROBIOLOGY, 62, 208-216. doi:10.1099/jmm.0.048272-0
Intraclonal genetic diversity amongst cystic fibrosis and keratitis isolates of Pseudomonas aeruginosa.
Hall, A. J., Fothergill, J. L., Kaye, S. B., Neal, T. J., McNamara, P. S., Southern, K. W., & Winstanley, C. (2013). Intraclonal genetic diversity amongst cystic fibrosis and keratitis isolates of Pseudomonas aeruginosa.. Journal of medical microbiology, 62(Pt 2), 208-216. doi:10.1099/jmm.0.048272-0
After a long wait, two arrive, one after the other!
Southern, K. W., McCormack, P., & McNamara, P. S. (2013). After a long wait, two arrive, one after the other!. THORAX, 68(4), 311-312. doi:10.1136/thoraxjnl-2012-202891
Induction of Th17 in nasopharynx-associated lymphoid tissue by pneumococcus and the effect of IL-21 and IL-15
Mubarak, A. S., Kasbekar, A., McCormick, M., Beer, H., Cunliffe, N., McNamara, P. S., & Zhang, Q. (2013). Induction of Th17 in nasopharynx-associated lymphoid tissue by pneumococcus and the effect of IL-21 and IL-15. In IMMUNOLOGY Vol. 140 (pp. 105). Retrieved from https://www.webofscience.com/
Investigating the mechanism of interaction between neutrophils and virus in Respiratory Syncytial Virus (RSV) disease
Saint, G. L., Flanagan, B. F., McNamara, P. S., & Smyth, R. L. (2013). Investigating the mechanism of interaction between neutrophils and virus in Respiratory Syncytial Virus (RSV) disease. In IMMUNOLOGY Vol. 140 (pp. 83-84). Retrieved from https://www.webofscience.com/
Respiratory syncytial virus infection of airway epithelial cells, in vivo and in vitro, supports pulmonary antibody responses by inducing expression of the B cell differentiation factor BAFF
McNamara, P. S., Fonceca, A. M., Howarth, D., Correia, J. B., Slupsky, J. R., Trinick, R. E., . . . Flanagan, B. F. (2013). Respiratory syncytial virus infection of airway epithelial cells, in vivo and in vitro, supports pulmonary antibody responses by inducing expression of the B cell differentiation factor BAFF. THORAX, 68(1), 76-81. doi:10.1136/thoraxjnl-2012-202288
2012
New Nebulizer Technology to Monitor Adherence and Nebulizer Performance in Cystic Fibrosis
McCormack, P., Southern, K. W., & McNamara, P. S. (2012). New Nebulizer Technology to Monitor Adherence and Nebulizer Performance in Cystic Fibrosis. JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 25(6), 307-309. doi:10.1089/jamp.2011.0934
The impact of the H1N1 influenza pandemic on clinical presentations and viral epidemiology of acute respiratory infection in preschool children in Brazil.
Fawkner-Corbett, D. W., Duarte, M. C. M. B., Rose, K., Fonceca, A., Bezerra, P., Hopkins, M., . . . McNamara, P. S. (2012). The impact of the H1N1 influenza pandemic on clinical presentations and viral epidemiology of acute respiratory infection in preschool children in Brazil.. The Pediatric infectious disease journal, 31(6), 653-655. doi:10.1097/inf.0b013e3182501ff4
Assessing the Liverpool Respiratory Symptom Questionnaire in children with cystic fibrosis
Trinick, R., Southern, K. W., & McNamara, P. S. (2012). Assessing the Liverpool Respiratory Symptom Questionnaire in children with cystic fibrosis. EUROPEAN RESPIRATORY JOURNAL, 39(4), 899-905. doi:10.1183/09031936.00070311
IFITM3 restricts the morbidity and mortality associated with influenza
Everitt, A. R., Clare, S., Pertel, T., John, S. P., Wash, R. S., Smith, S. E., . . . Kellam, P. (2012). IFITM3 restricts the morbidity and mortality associated with influenza. NATURE, 484(7395), 519-U146. doi:10.1038/nature10921
Primary airway epithelial cultures from children are highly permissive to respiratory syncytial virus infection
Fonceca, A. M., Flanagan, B. F., Trinick, R., Smyth, R. L., & McNamara, P. S. (2012). Primary airway epithelial cultures from children are highly permissive to respiratory syncytial virus infection. THORAX, 67(1), 42-48. doi:10.1136/thoraxjnl-2011-200131
Reflux aspiration in children with neurodisability-a significant problem, but can we measure it?
Trinick, R., Johnston, N., Dalzell, A. M., & McNamara, P. S. (2012). Reflux aspiration in children with neurodisability-a significant problem, but can we measure it?. JOURNAL OF PEDIATRIC SURGERY, 47(2), 291-298. doi:10.1016/j.jpedsurg.2011.11.019
THE IMPACT OF THE H1N1 INFLUENZA PANDEMIC ON CLINICAL PRESENTATIONS AND VIRAL EPIDEMIOLOGY OF ACUTE RESPIRATORY INFECTION IN PRESCHOOL CHILDREN IN BRAZIL
Fawkner-Corbett, D. W., Duarte, M. D. C. M. B., Rose, K., Fonceca, A., Bezerra, P., Hopkins, M., . . . McNamara, P. S. (2012). THE IMPACT OF THE H1N1 INFLUENZA PANDEMIC ON CLINICAL PRESENTATIONS AND VIRAL EPIDEMIOLOGY OF ACUTE RESPIRATORY INFECTION IN PRESCHOOL CHILDREN IN BRAZIL. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 31(6), 653-655. doi:10.1097/INF.0b013e3182501ff4
2011
A randomised controlled trial of breathing modes for adaptive aerosol delivery in children with cystic fibrosis
McCormack, P., McNamara, P. S., & Southern, K. W. (2011). A randomised controlled trial of breathing modes for adaptive aerosol delivery in children with cystic fibrosis. JOURNAL OF CYSTIC FIBROSIS, 10(5), 343-349. doi:10.1016/j.jcf.2011.04.006
Characterisation of Regulatory T Cells in Nasal Associated Lymphoid Tissue in Children: Relationships with Pneumococcal Colonization
Zhang, Q., Leong, S. C., McNamara, P. S., Mubarak, A., Malley, R., & Finn, A. (2011). Characterisation of Regulatory T Cells in Nasal Associated Lymphoid Tissue in Children: Relationships with Pneumococcal Colonization. PLOS PATHOGENS, 7(8). doi:10.1371/journal.ppat.1002175
Viral and Atypical Bacterial Detection in Acute Respiratory Infection in Children Under Five Years
Bezerra, P. G. M., Britto, M. C. A., Correia, J. B., Duarte, M. D. C. M. B., Fonceca, A. M., Rose, K., . . . McNamara, P. S. (2011). Viral and Atypical Bacterial Detection in Acute Respiratory Infection in Children Under Five Years. PLOS ONE, 6(4). doi:10.1371/journal.pone.0018928
Array tube genotyping of Pseudomonas aeruginosa isolates as a strategy for identifying potential emerging transmissible strains.
Hall, A. J., Fothergill, J. L., Southern, K. W., McNamara, P. S., Ledson, M. J., Walshaw, M. J., & Winstanley, C. (2011). Array tube genotyping of Pseudomonas aeruginosa isolates as a strategy for identifying potential emerging transmissible strains.. Journal of Cystic Fibrosis, 10 (S1, S32.
2010
Microarray genotyping of Pseudomonas aeruginosa isolates from CF units
Hall, A. J., Fothergill, J. L., Southern, K. W., McNamara, P. S., Ledson, M. J., Walshaw, M. J., & Winstanley, C. (2010). Microarray genotyping of Pseudomonas aeruginosa isolates from CF units. Journal of Cystic Fibrosis, 9, S30. doi:10.1016/s1569-1993(10)60115-4
2009
Open adherence monitoring using routine data download from an adaptive aerosol delivery nebuliser in children with cystic fibrosis
McNamara, P. S., McCormack, P., McDonald, A. J., Heaf, L., & Southern, K. W. (2009). Open adherence monitoring using routine data download from an adaptive aerosol delivery nebuliser in children with cystic fibrosis. JOURNAL OF CYSTIC FIBROSIS, 8(4), 258-263. doi:10.1016/j.jcf.2009.04.006
A reducing prevalence of the Liverpool Epidemic Strain of Pseudomonas aeruginosa in children attending the index paediatric clinic.
Morris, D., Fallon, L., Heaf, L., Burrows, E. F., Wallace, H., McNamara, P. S., . . . Southern, K. W. (2009). A reducing prevalence of the Liverpool Epidemic Strain of Pseudomonas aeruginosa in children attending the index paediatric clinic.. Ped Pulmonol, 32, 325.
2008
Comparison of techniques for obtaining lower airway epithelial cells from children
McNamara, P. S., Kicic, A., Sutanto, E. N., Stevens, P. T., & Stick, S. M. (2008). Comparison of techniques for obtaining lower airway epithelial cells from children. EUROPEAN RESPIRATORY JOURNAL, 32(3), 763-768. doi:10.1183/09031936.00162507
2007
Impact of human Metapneumovirus and Respiratory Syncytial Virus co-infection in severe bronchiolitis
McNamara, P. S., Flanagan, B. F., Smyth, R. L., & Hart, C. A. (2007). Impact of human Metapneumovirus and Respiratory Syncytial Virus co-infection in severe bronchiolitis. PEDIATRIC PULMONOLOGY, 42(8), 740-743. doi:10.1002/ppul.20649
2005
Interleukin-9 as a possible therapeutic target in both asthma and chronic obstructive airways disease
McNamara, P. S., & Smyth, R. L. (2005). Interleukin-9 as a possible therapeutic target in both asthma and chronic obstructive airways disease. DRUG NEWS & PERSPECTIVES, 18(10), 615-621. doi:10.1358/dnp.2005.18.10.959575
Production of chemokines in the lungs of infants with severe respiratory syncytial virus bronchiolitis
McNamara, P. S., Flanagan, B. F., Hart, C. A., & Smyth, R. L. (2005). Production of chemokines in the lungs of infants with severe respiratory syncytial virus bronchiolitis. JOURNAL OF INFECTIOUS DISEASES, 191(8), 1225-1232. doi:10.1086/428855
Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis
Semple, M. G., Cowell, A., Dove, W., Greensill, J., McNamara, P. S., Halfhide, C., . . . Hart, C. A. (2005). Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis. JOURNAL OF INFECTIOUS DISEASES, 191(3), 382-386. doi:10.1086/426457
2004
Interleukin 9 production in the lungs of infants with severe respiratory syncytial virus bronchlolitis
McNamara, P. S., Flanagan, B. F., Baldwin, L. M., Newland, P., Hart, C. A., & Smyth, R. L. (2004). Interleukin 9 production in the lungs of infants with severe respiratory syncytial virus bronchlolitis. LANCET, 363(9414), 1031-1037. doi:10.1016/S0140-6736(04)15838-8
Cytokines in severe Respiratory Syncytial Virus bronchiolitis
McNamara, P. S. (2004). Cytokines in severe Respiratory Syncytial Virus bronchiolitis. (PhD Thesis, The University of Liverpool).
Pro- and anti-inflammatory responses in respiratory syncytial virus bronchiolitis
McNamara, P. S., Flanagan, B. F., Selby, A. M., Hart, C. A., & Smyth, R. L. (2004). Pro- and anti-inflammatory responses in respiratory syncytial virus bronchiolitis. EUROPEAN RESPIRATORY JOURNAL, 23(1), 106-112. doi:10.1183/09031936.03.00048103
2003
Bronchoalveolar lavage cellularity in infants with severe respiratory syncytial virus bronchiolitis
McNamara, P. S., Ritson, P., Selby, A., Hart, C. A., & Smyth, R. L. (2003). Bronchoalveolar lavage cellularity in infants with severe respiratory syncytial virus bronchiolitis. ARCHIVES OF DISEASE IN CHILDHOOD, 88(10), 922-926. doi:10.1136/adc.88.10.922
Human metapneumovirus in severe respiratory syncytial virus bronchiolitis
Greensill, J., McNamara, P. S., Dove, W., Flanagan, B., Smyth, R. L., & Hart, C. A. (2003). Human metapneumovirus in severe respiratory syncytial virus bronchiolitis. EMERGING INFECTIOUS DISEASES, 9(3), 372-375. doi:10.3201/eid0903.020289
2002
A parent completed questionnaire to describe the patterns of wheezing and other respiratory symptoms in infants and preschool children
Powell, C. V. E., McNamara, P., Solis, A., & Shaw, N. J. (2002). A parent completed questionnaire to describe the patterns of wheezing and other respiratory symptoms in infants and preschool children. ARCHIVES OF DISEASE IN CHILDHOOD, 87(5), 376-379. doi:10.1136/adc.87.5.376
The pathogenesis of respiratory syncytial virus disease in childhood
McNamara, P. S., & Smyth, R. L. (2002). The pathogenesis of respiratory syncytial virus disease in childhood. BRITISH MEDICAL BULLETIN, 61, 13-28. doi:10.1093/bmb/61.1.13
2001
Headache and abdominal pain
McNamara, P. S., Mallucci, C. L., & Appleton, R. T. (2001). Headache and abdominal pain. LANCET, 357(9260), 930. doi:10.1016/S0140-6736(00)04215-X