Publications
2024
Lysosomal signalling pathways influence heart rhythm, and regulate atrial function
Identification and characterisation of functional Kir6.1-containing ATP-sensitive potassium channels in the cardiac ventricular sarcolemmal membrane
Brennan, S., Chen, S., Makwana, S., Esposito, S., McGuinness, L., Alnaimi, A., . . . Rainbow, R. (2024). Identification and characterisation of functional Kir6.1-containing ATP-sensitive potassium channels in the cardiac ventricular sarcolemmal membrane. British Journal of Pharmacology. doi:10.1111/bph.16390
2023
Slowly activating voltage-gated potassium current potentiation by ML277 is a novel cardioprotective intervention
Brennan, S., Alnaimi, A. I. M., Mcguinness, L. R., Abdelaziz, M. I. M., Mckenzie, R. A., Draycott, S., . . . Rainbow, R. D. (2023). Slowly activating voltage-gated potassium current potentiation by ML277 is a novel cardioprotective intervention. PNAS NEXUS, 2(5). doi:10.1093/pnasnexus/pgad156
Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling
Roberts, J. A., Rainbow, R. D., & Sharma, P. (2023). Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(7). doi:10.3390/ijms24076723
2022
Doxorubicin mediated impairment of vascular tone and recovery by NRF2 antioxidant pathway activator CDDO.
Verma, A., Sharma, P., & Rainbow, R. D. (2022). Doxorubicin mediated impairment of vascular tone and recovery by NRF2 antioxidant pathway activator CDDO.. In ACTA PHYSIOLOGICA Vol. 236 (pp. 879-881). Retrieved from https://www.webofscience.com/
Identification of differentially expressed genes and functional activity of ion channels and receptors in rat vascular tissues
Alanazi, F. M., Sharma, P., & Rainbow, R. D. (2022). Identification of differentially expressed genes and functional activity of ion channels and receptors in rat vascular tissues. In ACTA PHYSIOLOGICA Vol. 236 (pp. 881). Retrieved from https://www.webofscience.com/
Selective PKC inhibition switches time-dependent glucose cardiotoxicity to cardioprotection.
Brennan, S., Esposito, S., Abdelaziz, M. I., Martin, C. A., Makwana, S., Sims, M. W., . . . Rainbow, R. D. (2022). Selective PKC inhibition switches time-dependent glucose cardiotoxicity to cardioprotection.. In ACTA PHYSIOLOGICA Vol. 236 (pp. 587-589). Retrieved from https://www.webofscience.com/
THE CARDIOPROTECTIVE ROLE OF IKS POTENTIATION AGANIST ISCHAEMIC INJURY
Alnaimi, A. I., Brennan, S., Rainbow, R., & Sharma, P. (2022). THE CARDIOPROTECTIVE ROLE OF IKS POTENTIATION AGANIST ISCHAEMIC INJURY. In ACTA PHYSIOLOGICA Vol. 236 (pp. 945). Retrieved from https://www.webofscience.com/
Selective protein kinase C inhibition switches time-dependent glucose cardiotoxicity to cardioprotection
Brennan, S., Esposito, S., Abdelaziz, M. I. M., Martin, C. A. A., Makwana, S., Sims, M. W. W., . . . Rainbow, R. D. (2022). Selective protein kinase C inhibition switches time-dependent glucose cardiotoxicity to cardioprotection. FRONTIERS IN CARDIOVASCULAR MEDICINE, 9. doi:10.3389/fcvm.2022.997013
Defining the importance of the mitochondrial genome in the role of NAFLD using 3D in vitro transmitochondrial cybrid steatotic and fibrotic models
Jensen, R., Chadwick, A., Sharma, P., & Williams, D. (2022). Defining the importance of the mitochondrial genome in the role of NAFLD using 3D in vitro transmitochondrial cybrid steatotic and fibrotic models. In TOXICOLOGY LETTERS Vol. 368 (pp. S54). doi:10.1016/j.toxlet.2022.07.165
2021
Characterization of a high throughput human stem cell cardiomyocyte assay to predict drug-induced changes in clinical electrocardiogram parameters
Kilfoil, P., Feng, S. L., Bassyouni, A., Lee, T., Leishman, D., Li, D., . . . Jenkinson, S. (2021). Characterization of a high throughput human stem cell cardiomyocyte assay to predict drug-induced changes in clinical electrocardiogram parameters. European Journal of Pharmacology, 174584. doi:10.1016/j.ejphar.2021.174584
Drugs in phase I and II clinical development for the prevention of stroke in patients with atrial fibrillation
Bentley, R., Hardy, L. J., Scott, L. J., Sharma, P., Philippou, H., & Lip, G. Y. H. (2021). Drugs in phase I and II clinical development for the prevention of stroke in patients with atrial fibrillation. Expert Opinion on Investigational Drugs. doi:10.1080/13543784.2021.1897786
Pathophysiological insights into atrial fibrillation: revisiting the electrophysiological substrate, anatomical substrate, and possible insights from proteomics
Bentley, R., Logantha, S. J. R. J., Sharma, P., Rainbow, R. R., & Lip, G. Y. H. (2021). Pathophysiological insights into atrial fibrillation: revisiting the electrophysiological substrate, anatomical substrate, and possible insights from proteomics. CARDIOVASCULAR RESEARCH, 117(3), E41-E45. doi:10.1093/cvr/cvaa276
Editorial: Tissue Engineering for Drug Discovery and Personalized Medicine
Ramadan, Q., & Sharma, P. (2021). Editorial: Tissue Engineering for Drug Discovery and Personalized Medicine. FRONTIERS IN MEDICAL TECHNOLOGY, 3. doi:10.3389/fmedt.2021.663057
2020
Bioinformatic analysis of membrane and associated proteins in murine cardiomyocytes and human myocardium
Lee, S. -H., Hadipour-Lakmehsari, S., Kim, D. H., Di Paola, M., Kuzmanov, U., Shah, S., . . . Gramolini, A. O. (2020). Bioinformatic analysis of membrane and associated proteins in murine cardiomyocytes and human myocardium. SCIENTIFIC DATA, 7(1). doi:10.1038/s41597-020-00762-1
Mapping signalling perturbations in myocardial fibrosis via the integrative phosphoproteomic profiling of tissue from diverse sources
Kuzmanov, U., Wang, E. Y., Vanderlaan, R., Kim, D. H., Lee, S. -H., Hadipour-Lakmehsari, S., . . . Emili, A. (2020). Mapping signalling perturbations in myocardial fibrosis via the integrative phosphoproteomic profiling of tissue from diverse sources. Nature Biomedical Engineering, 4(9), 889-900. doi:10.1038/s41551-020-0585-y
REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects
Lee, S. -H., Hadipour-Lakmehsari, S., Murthy, H. R., Gibb, N., Miyake, T., Teng, A. C. T., . . . Gramolini, A. O. (2020). REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects. NATURE COMMUNICATIONS, 11. doi:10.1038/s41467-019-14143-9
Multiscale modelling of drug transport and metabolism in liver spheroids
Leedale, J. A., Kyffin, J., Harding, A., Colley, H., Murdoch, C., Sharma, P., . . . Bearon, R. (2020). Multiscale modelling of drug transport and metabolism in liver spheroids. Interface Focus, 10(2). doi:10.1098/rsfs.2019.0041
Current Perspective: 3D Spheroid Models Utilizing Human-Based Cells for Investigating Metabolism-Dependent Drug-Induced Liver Injury
Cox, C. R., Lynch, S., Goldring, C., & Sharma, P. (2020). Current Perspective: 3D Spheroid Models Utilizing Human-Based Cells for Investigating Metabolism-Dependent Drug-Induced Liver Injury. FRONTIERS IN MEDICAL TECHNOLOGY, 2. doi:10.3389/fmedt.2020.611913
2019
Preparation of Primary Rat Hepatocyte Spheroids Utilizing the Liquid-Overlay Technique.
Kyffin, J. A., Cox, C. R., Leedale, J., Colley, H. E., Murdoch, C., Mistry, P., . . . Sharma, P. (2019). Preparation of Primary Rat Hepatocyte Spheroids Utilizing the Liquid-Overlay Technique.. Current protocols in toxicology, 81(1), e87. doi:10.1002/cptx.87
Defining the physiological relevance of bile acid induced mitochondrial dysfunction
Penman, S. L., Sharma, P., Park, B. K., Aerts, H., Weaver, R. J., & Chadwick, A. (2019). Defining the physiological relevance of bile acid induced mitochondrial dysfunction. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 176 (pp. 3043). Retrieved from https://www.webofscience.com/
Development and validation of an in vitro model for drug-induced non-alcoholic fatty liver disease
Nedzveckaite, R., Sharma, P., & Pushpakom, S. (2019). Development and validation of an in vitro model for drug-induced non-alcoholic fatty liver disease. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 176 (pp. 3058-3059). Retrieved from https://www.webofscience.com/
Stem cell models as an <i>in vitro</i> model for predictive toxicology
Lynch, S., Pridgeon, C. S., Duckworth, C. A., Sharma, P., Park, B. K., & Goldring, C. E. P. (2019). Stem cell models as an <i>in vitro</i> model for predictive toxicology. BIOCHEMICAL JOURNAL, 476, 1149-1158. doi:10.1042/BCJ20170780
Attenuation of doxorubicin-induced cardiotoxicity in a human in vitro cardiac model by the induction of the NRF-2 pathway
Tomlinison, L., Lu, Z. Q., Bentley, R., Colley, H., Murdoch, C., Webb, S., . . . Sharma, P. (n.d.). Attenuation of doxorubicin-induced cardiotoxicity in a human in vitro cardiac model by the induction of the NRF-2 pathway. Biomedicine and Pharmacotherapy. doi:10.1016/j.biopha.2019.108637
Characterisation of a functional rat hepatocyte spheroid model
Kyffin, J. A., Sharma, P., Leedale, J., Colley, H. E., Murdoch, C., Harding, A. L., . . . Webb, S. D. (2019). Characterisation of a functional rat hepatocyte spheroid model. TOXICOLOGY IN VITRO, 55, 160-172. doi:10.1016/j.tiv.2018.12.014
<i>In vitro</i> Liver Zonation of Primary Rat Hepatocytes
Tomlinson, L., Hyndman, L., Firman, J. W., Bentley, R., Kyffin, J. A., Webb, S. D., . . . Sharma, P. (2019). <i>In vitro</i> Liver Zonation of Primary Rat Hepatocytes. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 7. doi:10.3389/fbioe.2019.00017
2018
A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity
Leedale, J., Sharkey, K., Colley, H., Norton, A., Peeney, D., Mason, C., . . . Webb, S. (2018). A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity. iScience, 4, 84-96. doi:10.1016/j.isci.2018.05.012
Expression and enzyme activity of cytochrome P450 enzymes CYP3A4 and CYP3A5 in human skin and tissue‐engineered skin equivalents
Smith, S., Colley, H., Sharma, P., Slowik, K., Sison-Young, R., Sneddon, A., . . . Murdoch, C. (2018). Expression and enzyme activity of cytochrome P450 enzymes CYP3A4 and CYP3A5 in human skin and tissue‐engineered skin equivalents. Experimental Dermatology, 27(5), 473-475. doi:10.1111/exd.13483
Impact of cell types and culture methods on the functionality of <i>in vitro</i> liver systems - A review of cell systems for hepatotoxicity assessment
Kyffin, J. A., Sharma, P., Leedale, J., Colley, H. E., Murdoch, C., Mistry, P., & Webb, S. D. (2018). Impact of cell types and culture methods on the functionality of <i>in vitro</i> liver systems - A review of cell systems for hepatotoxicity assessment. TOXICOLOGY IN VITRO, 48, 262-275. doi:10.1016/j.tiv.2018.01.023
2017
In silico prediction of skin metabolism and its implication in toxicity assessment
Madden, J. C., Webb, S., Enoch, S. J., Colley, H. E., Murdoch, C., Shipley, R., . . . Cronin, M. T. D. (2017). In silico prediction of skin metabolism and its implication in toxicity assessment. Computational Toxicology, 3, 44-57. doi:10.1016/j.comtox.2017.07.001
2016
Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy
Kuzmanov, U., Guo, H., Buchsbaum, D., Cosme, J., Abbasi, C., Isserlin, R., . . . Emili, A. (2016). Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy. Proceedings of the National Academy of Sciences, 113(44), 12592-12597. doi:10.1073/pnas.1606444113
Characterization of a Functional C3A Liver Spheroid Model
Gaskell, H., Sharma, P., Colley, H. E., Murdoch, C., Williams, D. P., & Webb, S. D. (2016). Characterization of a Functional C3A Liver Spheroid Model. Toxicological Research, 5(04), 1053-1065. doi:10.1039/C6TX00101G.
Developments in Cardiovascular Proteomics
A Noronha, M., & Linden, C. (n.d.). Developments in Cardiovascular Proteomics. Journal of Proteomics & Bioinformatics, 09(05). doi:10.4172/jpb.1000400
2015
Development and characterisation of a functional 3D liver spheroid model
Gaskell, H., Sharma, P., Colley, H., Murdoch, C., Antoine, D., Sathish, J., . . . Webb, S. (2015). Development and characterisation of a functional 3D liver spheroid model. In TOXICOLOGY LETTERS Vol. 238 (pp. S176). doi:10.1016/j.toxlet.2015.08.511
Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function
Sharma, P., Abbasi, C., Lazic, S., Teng, A. C. T., Wang, D., Dubois, N., . . . Gramolini, A. O. (2015). Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nature Communications, 6. doi:10.1038/ncomms9391
Abstract 187: Metformin Increases Degradation of Ubiquitinylated Phospholamban via Autophagy in Cardiomyocytes
Teng, A. C., Miyake, T., Yokoe, S., Zhang, L., Rezende, L. M., Sharma, P., . . . Gramolini, A. O. (2015). Abstract 187: Metformin Increases Degradation of Ubiquitinylated Phospholamban via Autophagy in Cardiomyocytes. Circulation Research, 117(suppl_1). doi:10.1161/res.117.suppl_1.187
Metformin increases degradation of phospholamban via autophagy in cardiomyocytes.
Teng, A. C. T., Miyake, T., Yokoe, S., Zhang, L., Rezende, L. M., Sharma, P., . . . Gramolini, A. O. (2015). Metformin increases degradation of phospholamban via autophagy in cardiomyocytes.. Proceedings of the National Academy of Sciences of the United States of America, 112(23), 7165-7170. doi:10.1073/pnas.1508815112
2014
Proteomic Analysis of Human Fetal Atria and Ventricle
Lu, Z. Q., Sinha, A., Sharma, P., Kislinger, T., & Gramolini, A. O. (2014). Proteomic Analysis of Human Fetal Atria and Ventricle. JOURNAL OF PROTEOME RESEARCH, 13(12), 5869-5878. doi:10.1021/pr5007685
Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects.
Wang, D. -Y., Abbasi, C., El-Rass, S., Li, J. Y., Dawood, F., Naito, K., . . . Gramolini, A. O. (2014). Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects.. Journal of the American Heart Association, 3(5), e001018. doi:10.1161/JAHA.114.001018
HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress
Zhang, L., Chen, X., Sharma, P., Moon, M., Sheftel, A. D., Dawood, F., . . . Liu, P. P. (2014). HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. Nature Communications, 5. doi:10.1038/ncomms4430
Swelling-activated Cl- currents and intracellular CLC-3 are involved in proliferation of human pulmonary artery smoothmuscle cells
Liang, W., Huang, L., Zhao, D., He, J. Z., Sharma, P., Liu, J., . . . Backx, P. H. (2014). Swelling-activated Cl- currents and intracellular CLC-3 are involved in proliferation of human pulmonary artery smoothmuscle cells. Journal of Hypertension, 32(2), 318-330. doi:10.1097/HJH.0000000000000013
2013
Recent advances in cardiovascular proteomics
Sharma, P., Cosme, J., & Gramolini, A. O. (2013). Recent advances in cardiovascular proteomics. JOURNAL OF PROTEOMICS, 81, 3-14. doi:10.1016/j.jprot.2012.10.026
2012
α-Crystallin B prevents apoptosis after H<sub>2</sub>O<sub>2</sub> exposure in mouse neonatal cardiomyocytes
Chis, R., Sharma, P., Bousette, N., Miyake, T., Wilson, A., Backx, P. H., & Gramolini, A. O. (2012). α-Crystallin B prevents apoptosis after H<sub>2</sub>O<sub>2</sub> exposure in mouse neonatal cardiomyocytes. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 303(8), H967-H978. doi:10.1152/ajpheart.00040.2012
Structural determination of the phosphorylation domain of the ryanodine receptor
Sharma, P., Ishiyama, N., Nair, U., Li, W., Dong, A., Miyake, T., . . . Gramolini, A. O. (2012). Structural determination of the phosphorylation domain of the ryanodine receptor. FEBS JOURNAL, 279(20), 3952-3964. doi:10.1111/j.1742-4658.2012.08755.x
126 αCrystallin B Interacts With VDAC, CASPASE 3 and CASPASE 12 to Prevent Apoptosis Following H2O2 Exposure in Cardiomyocytes
Chis, R., Sharma, P., Bousette, N., Miyake, T., Wilson, A., Backx, P. H., & Gramolini, A. O. (2012). 126 αCrystallin B Interacts With VDAC, CASPASE 3 and CASPASE 12 to Prevent Apoptosis Following H2O2 Exposure in Cardiomyocytes. Canadian Journal of Cardiology, 28(5), S136-S137. doi:10.1016/j.cjca.2012.07.133
368 Cell Surface Proteomics in Primary Cardiomyocytes Reveals Ventricle-Specific Cardiomyocyte Maturation Markers
Sharma, P., Dubois, N., Bousette, N., Ignatchenko, A., Noronha, M., Ignatchenko, V., . . . Gramolini, A. O. (2012). 368 Cell Surface Proteomics in Primary Cardiomyocytes Reveals Ventricle-Specific Cardiomyocyte Maturation Markers. Canadian Journal of Cardiology, 28(5), S235-S236. doi:10.1016/j.cjca.2012.07.346
372 Autophagy is Required for the Degradation of Phospholamban in Mouse Neonatal Cardiomyocytes
Teng, A. C., Miyake, T., Sharma, P., Zhang, L., Liu, P., & Gramolini, A. O. (2012). 372 Autophagy is Required for the Degradation of Phospholamban in Mouse Neonatal Cardiomyocytes. Canadian Journal of Cardiology, 28(5), S237. doi:10.1016/j.cjca.2012.07.350
378 ERp44 Deficiency in Mice, Zebrafish and Mouse-Derived Embryonic Stem Cell Derived Cardiomyocytes Display Aberrant Ca2 Homeostasis, ER Stress Induced Apoptosis and Cardiomyopathy
Wang, D. Y., Abbasi, C., Li, Y. J., El-Rass, S., Tang, G., Dawood, F., . . . Gramolini, A. (2012). 378 ERp44 Deficiency in Mice, Zebrafish and Mouse-Derived Embryonic Stem Cell Derived Cardiomyocytes Display Aberrant Ca2 Homeostasis, ER Stress Induced Apoptosis and Cardiomyopathy. Canadian Journal of Cardiology, 28(5), S240. doi:10.1016/j.cjca.2012.07.356
Clinical Proteomics Getting to the Heart of the Matter
Chugh, S., Sharma, P., Kislinger, T., & Gramolini, A. O. (2012). Clinical Proteomics Getting to the Heart of the Matter. CIRCULATION-CARDIOVASCULAR GENETICS, 5(3), O1-O9. doi:10.1161/CIRCGENETICS.110.957761
Cell-Surface Proteomics Identifies Lineage-Specific Markers of Embryo-Derived Stem Cells
Rugg-Gunn, P. J., Cox, B. J., Lanner, F., Sharma, P., Ignatchenko, V., McDonald, A. C. H., . . . Kislinger, T. (2012). Cell-Surface Proteomics Identifies Lineage-Specific Markers of Embryo-Derived Stem Cells. DEVELOPMENTAL CELL, 22(4), 887-901. doi:10.1016/j.devcel.2012.01.005
AUTOPHAGY IS REQUIRED FOR THE DEGRADATION OF PHOSPHOLAMBAN IN MOUSE NEONATAL CARDIOMYOCYTES
Teng, A. C., Miyake, T., Sharma, P., Zhang, L., Liu, P., & Gramolini, A. O. (2012). AUTOPHAGY IS REQUIRED FOR THE DEGRADATION OF PHOSPHOLAMBAN IN MOUSE NEONATAL CARDIOMYOCYTES. In CANADIAN JOURNAL OF CARDIOLOGY Vol. 28 (pp. S237). doi:10.1016/j.cjca.2012.07.350
2011
Translational Analysis of Mouse and Human Placental Protein and mRNA Reveals Distinct Molecular Pathologies in Human Preeclampsia
Cox, B., Sharma, P., Evangelou, A. I., Whiteley, K., Ignatchenko, V., Ignatchenko, A., . . . Kislinger, T. (2011). Translational Analysis of Mouse and Human Placental Protein and mRNA Reveals Distinct Molecular Pathologies in Human Preeclampsia. MOLECULAR & CELLULAR PROTEOMICS, 10(12). doi:10.1074/mcp.M111.012526
SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells
Dubois, N. C., Craft, A. M., Sharma, P., Elliott, D. A., Stanley, E. G., Elefanty, A. G., . . . Keller, G. (2011). SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells. NATURE BIOTECHNOLOGY, 29(11), 1011-1U82. doi:10.1038/nbt.2005
280 Proteomic profiling of mouse and human cardiac membrane proteins reveals novel cardiac proteins
Sharma, P., Bousette, N., Ignatchenko, A., Noronha, M., Ignatchenko, V., Dubois, N., . . . Gramolini, A. O. (2011). 280 Proteomic profiling of mouse and human cardiac membrane proteins reveals novel cardiac proteins. Canadian Journal of Cardiology, 27(5), S163. doi:10.1016/j.cjca.2011.07.208
286 Elucidation of the protective mechanism of α Crystallin B in cardiomyocytes
Chis, R., Bousette, N., Sharma, P., Miyake, T., & Gramolini, A. (2011). 286 Elucidation of the protective mechanism of α Crystallin B in cardiomyocytes. Canadian Journal of Cardiology, 27(5), S166. doi:10.1016/j.cjca.2011.07.214
293 A translational proteomics analysis of the blood-tissue interface in the vascular bed of the mouse placenta identifies markers of human vascular diseases
Sharma, P., Cox, B., Evangelou, A. I., Whiteley, K., Ignatchenko, V., Ignatchenko, A., . . . Kislinger, T. (2011). 293 A translational proteomics analysis of the blood-tissue interface in the vascular bed of the mouse placenta identifies markers of human vascular diseases. Canadian Journal of Cardiology, 27(5), S169-S170. doi:10.1016/j.cjca.2011.07.221
539 Crystallisation and characterisation of the phosphorylation domain of the ryanodine receptor
Sharma, P., Li, W., Nair, U., Miyake, T., Dong, A., Kislinger, T., . . . Gramolini, A. O. (2011). 539 Crystallisation and characterisation of the phosphorylation domain of the ryanodine receptor. Canadian Journal of Cardiology, 27(5), S256. doi:10.1016/j.cjca.2011.07.447
Identification of Novel Ryanodine Receptor 1 (RyR1) Protein Interaction with Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP)
Ryan, T., Sharma, P., Ignatchenko, A., MacLennan, D. H., Kislinger, T., & Gramolini, A. O. (2011). Identification of Novel Ryanodine Receptor 1 (RyR1) Protein Interaction with Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP). JOURNAL OF BIOLOGICAL CHEMISTRY, 286(19), 17060-17068. doi:10.1074/jbc.M110.197186
Identification of an FHL1 protein complex containing ACTN1, ACTN4, and PDLIM1 using affinity purifications and MS-based protein-protein interaction analysis
Sharma, P., Shathasivam, T., Ignatchenko, V., Kislinger, T., & Gramolini, A. O. (2011). Identification of an FHL1 protein complex containing ACTN1, ACTN4, and PDLIM1 using affinity purifications and MS-based protein-protein interaction analysis. MOLECULAR BIOSYSTEMS, 7(4), 1185-1196. doi:10.1039/c0mb00235f
ELUCIDATION OF THE PROTECTIVE MECHANISM OF A CRYSTALLIN B IN CARDIOMYOCYTES
Chis, R., Bousette, N., Sharma, P., Miyake, T., & Gramolini, A. (2011). ELUCIDATION OF THE PROTECTIVE MECHANISM OF A CRYSTALLIN B IN CARDIOMYOCYTES. In CANADIAN JOURNAL OF CARDIOLOGY Vol. 27 (pp. S166). doi:10.1016/j.cjca.2011.07.214
Use of Colloidal Silica-Beads for the Isolation of Cell-Surface Proteins for Mass Spectrometry-Based Proteomics
Kim, Y., Elschenbroich, S., Sharma, P., Sepiashvili, L., Gramolini, A. O., & Kislinger, T. (2011). Use of Colloidal Silica-Beads for the Isolation of Cell-Surface Proteins for Mass Spectrometry-Based Proteomics. IMMUNE RECEPTORS: METHODS AND PROTOCOLS, 748, 227-241. doi:10.1007/978-1-61779-139-0_16
2010
Endoplasmic Reticulum Protein Targeting of Phospholamban: A Common Role for an N-Terminal Di-Arginine Motif in ER Retention?
Sharma, P., Ignatchenko, V., Grace, K., Ursprung, C., Kislinger, T., & Gramolini, A. O. (2010). Endoplasmic Reticulum Protein Targeting of Phospholamban: A Common Role for an N-Terminal Di-Arginine Motif in ER Retention?. PLOS ONE, 5(7). doi:10.1371/journal.pone.0011496
2009
Peptide Separations by On-Line MudPIT Compared to Isoelectric Focusing in an Off-Gel Format: Application to a Membrane-Enriched Fraction from C2C12 Mouse Skeletal Muscle Cells
Elschenbroich, S., Ignatchenko, V., Sharma, P., Schmitt-Ulms, G., Gramolini, A. O., & Kislinger, T. (2009). Peptide Separations by On-Line MudPIT Compared to Isoelectric Focusing in an Off-Gel Format: Application to a Membrane-Enriched Fraction from C2C12 Mouse Skeletal Muscle Cells. JOURNAL OF PROTEOME RESEARCH, 8(10), 4860-4869. doi:10.1021/pr900318k
2008
Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses
Gramolini, A. O., Kislinger, T., Alikhani-Koopaei, R., Fong, V., Thompson, N. J., Isserlin, R., . . . Emili, A. (2008). Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses. MOLECULAR & CELLULAR PROTEOMICS, 7(3), 519-533. doi:10.1074/mcp.M700245-MCP200
2005
Correlations between genotype and pharmacological, histological, functional, and clinical phenotypes in malignant hyperthermia susceptibility
Monnier, N., Kozak-Ribbens, G., Horber, R. K., Nivoche, Y., Qi, D., Kraev, N., . . . Lunardi, J. (2005). Correlations between genotype and pharmacological, histological, functional, and clinical phenotypes in malignant hyperthermia susceptibility. HUMAN MUTATION, 26(5), 413-425. doi:10.1002/humu.20231
Ca2+ signaling in HEK-293 and skeletal muscle cells expressing recombinant ryanodine receptors harboring malignant hyperthermia and central core disease mutations.
Brini, M., Manni, S., Pierobon, N., Du, G. G., Sharma, P., MacLennan, D. H., & Carafoli, E. (2005). Ca2+ signaling in HEK-293 and skeletal muscle cells expressing recombinant ryanodine receptors harboring malignant hyperthermia and central core disease mutations.. The Journal of biological chemistry, 280(15), 15380-15389. doi:10.1074/jbc.m410421200
2004
Role of the sequence surrounding predicted transmembrane helix M4 in membrane association and function of the Ca(2+) release channel of skeletal muscle sarcoplasmic reticulum (ryanodine receptor isoform 1).
Du, G. G., Avila, G., Sharma, P., Khanna, V. K., Dirksen, R. T., & MacLennan, D. H. (2004). Role of the sequence surrounding predicted transmembrane helix M4 in membrane association and function of the Ca(2+) release channel of skeletal muscle sarcoplasmic reticulum (ryanodine receptor isoform 1).. The Journal of biological chemistry, 279(36), 37566-37574. doi:10.1074/jbc.m406637200
2003
Detection of a novel ryanodine receptor subtype 1 mutation (R328W) in a malignant hyperthermia family by sequencing of a leukocyte transcript
Loke, J. C. P., Kraev, N., Sharma, P., Du, G. G., Patel, L., Kraev, A., & MacLennan, D. H. (2003). Detection of a novel ryanodine receptor subtype 1 mutation (R328W) in a malignant hyperthermia family by sequencing of a leukocyte transcript. ANESTHESIOLOGY, 99(2), 297-302. doi:10.1097/00000542-200308000-00011
2002
Involvement of the cytoplasmic loop L6-7 in the entry mechanism for transport of Ca2+ through the sarcoplasmic reticulum Ca2+-ATPase.
Menguy, T., Corre, F., Juul, B., Bouneau, L., Lafitte, D., Derrick, P. J., . . . le Maire, M. (2002). Involvement of the cytoplasmic loop L6-7 in the entry mechanism for transport of Ca2+ through the sarcoplasmic reticulum Ca2+-ATPase.. The Journal of biological chemistry, 277(15), 13016-13028. doi:10.1074/jbc.m108899200
2001
Cytoplasmic interactions between phospholamban residues 1-20 and the calcium-activated ATPase of the sarcoplasmic reticulum
Sharma, P., Patchell, V. B., Gao, Y., Evans, J. S., & Levine, B. A. (2001). Cytoplasmic interactions between phospholamban residues 1-20 and the calcium-activated ATPase of the sarcoplasmic reticulum. BIOCHEMICAL JOURNAL, 355, 699-706. doi:10.1042/bj3550699
1999
Sites on the cytoplasmic region of phospholamban involved in interaction with the calcium-activated ATPase of the sarcoplasmic reticulum
Levine, B. A., Patchell, V. B., Sharma, P., Gao, Y., Bigelow, D. J., Yao, Q., . . . Perry, S. V. (1999). Sites on the cytoplasmic region of phospholamban involved in interaction with the calcium-activated ATPase of the sarcoplasmic reticulum. EUROPEAN JOURNAL OF BIOCHEMISTRY, 264(3), 905-913. doi:10.1046/j.1432-1327.1999.00688.x
1998
Interaction of the SR CaATPase with the cytoplasmic region of phospholamban
Sharma, P., Gao, Y., Longland, G., Michelangeli, F., Strasburg, G., Bigelow, D. J., . . . Levine, B. A. (1998). Interaction of the SR CaATPase with the cytoplasmic region of phospholamban. BIOCHEMICAL SOCIETY TRANSACTIONS, 26(3), S228. doi:10.1042/bst026s228