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Michael Schmid

Professor Michael Schmid

Research

Tumour microenvironment, Pancreatic cancer, Metastasis, Macrophages, Tumour immunity

Research Interests:
Tumour microenvironment, Pancreatic cancer, Metastasis, Macrophages, Tumour immunity

Research Summary:
In pancreatic ductal adenocarcinoma (PDAC), tumour infiltrating myeloid immune cells are now considered to play a critical role in promoting tumour progression and resistance to anti-cancer therapy. My laboratory investigates the interactions between myeloid immune cells and other cells composing the pancreatic tumour microenvironment, including pancreatic cancer cells and cancer associated fibroblasts and how myeloid cells modulate tumour responses to cytotoxic and immuno-therapies. In this endeavour, we utilize a variety of approaches such as animal modelling, cell biology, bioinformatics, and validation of findings in clinical samples.

For more information about our research, please visit our lab website www.schmidlab.org.

You can also watch a video about our research here In the Lab with Dr Michael Schmid

Funding:Medical Research Council; North West Cancer Research; Pancreatic Cancer Research Fund; Royal Society

Research grants

Liverpool ECMC (LECMC)

CANCER RESEARCH UK (UK)

April 2023 - March 2028

Whole Transcriptome Spatial Pro ling in Conjunctival Melanoma

THE PATHOLOGICAL SOCIETY (UK)

April 2024 - April 2025

Trans-venous occlusion of incompetent pelvic veins as a treatment for chronic pelvic pain in women: a randomised control trial

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

May 2015 - April 2017

Assessing Gas6+ neutrophils in the blood of pancreatic cancer patients undergoing chemotherapy to generate evidence for targeting Gas6/AXL signalling in patients

THE CLATTERBRIDGE CANCER CENTRE NHS FOUNDATION TRUST (UK)

September 2023 - August 2025

Bench fees for Mr Sufyan M A El Hashani 201182871

LIBYAN EMBASSY IN LONDON🚩

October 2020 - September 2024

Defining the hapatic metastatic niche in colorectal cancer on a single cell basis

NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

October 2021 - August 2022

The role of macrophage-derived granulin in pancreatic cancer metastasis - mechanisms and therapeutic opportunities.

MEDICAL RESEARCH COUNCIL

October 2017 - April 2022

Investigating the metastatic microenvironment in pancreatic cancer

CANCER RESEARCH UK (UK)

September 2018 - August 2025

Studying immune escape of disseminated cancer cells in pancreatic cancer

ROYAL SOCIETY (CHARITABLE)

March 2015 - March 2016

Role of monocytes in the metastatic process: identification of novel molecular targets to fight pancreatic cancer

PANCREATIC CANCER RESEARCH FUND (UK)

July 2015 - June 2019

Impact of targeting myeloid PI3Kg on the pancreatic tumour stroma compartment and the response to chemotherapy

MEDICAL RESEARCH COUNCIL

March 2014 - March 2017

Impact of tumour-associated myeloid cells on cancer stemness and chemotherapy-resistance

NORTH WEST CANCER RESEARCH FUND

March 2013 - December 2016

Development of BH3 profiling to assess tumour sensitivity to cancer chemotherapeutic agents

NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

November 2014 - November 2016

European Study Group for Pancreatic Cancer Trial 5F prospective sample collection - ESPAC-5FT

CANCER RESEARCH UK (UK)

September 2014 - December 2018