Skip to main content
Michael Schmid

Professor Michael Schmid

Publications

Selected publications

  1. Integrin CD11b activation drives anti-tumor innate immunity (Journal article - 2018)
  2. Macrophage-derived granulin drives resistance to immune checkpoint inhibition in metastatic pancreatic cancer (Journal article - 2018)
  3. Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis (Journal article - 2016)
  4. Macrophage PI3Kγ drives pancreatic ductal adenocarcinoma progression (Journal article - 2016)
  5. Receptor Tyrosine Kinases and TLR/IL1 Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression (Journal article - 2011)
  6. Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis (Journal article - 2022)
What type of publication do you want to show?

2024

Expression of versican isoforms V0/V1 by pancreatic cancer associated fibroblasts increases fibroblast proliferation.

Elhashani, S., Glenn, M., Raymant, M., Schmid, M. C., & Mielgo, A. (2024). Expression of versican isoforms V0/V1 by pancreatic cancer associated fibroblasts increases fibroblast proliferation.. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 24(5), 719-731. doi:10.1016/j.pan.2024.04.008

DOI
10.1016/j.pan.2024.04.008
Journal article

Abstract 1518: Understanding the role of VISTA in regulating T cells function and the therapeutic potential of blocking VISTA in triple negative breast cancer

Abudula, M., Astuti, Y., Raymant, M., Luckett, T., Freeman, P., Schmid, M., & Iza, A. M. (2024). Abstract 1518: Understanding the role of VISTA in regulating T cells function and the therapeutic potential of blocking VISTA in triple negative breast cancer. Cancer Research, 84(6_Supplement), 1518. doi:10.1158/1538-7445.am2024-1518

DOI
10.1158/1538-7445.am2024-1518
Journal article

Data from Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis

Luckett, T., Abudula, M., Ireland, L., Glenn, M., Bellomo, G., Stafferton, R., . . . Mielgo, A. (2024). Data from Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis. doi:10.1158/0008-5472.c.7075692

DOI
10.1158/0008-5472.c.7075692
Other

Data from Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis

Luckett, T., Abudula, M., Ireland, L., Glenn, M., Bellomo, G., Stafferton, R., . . . Mielgo, A. (2024). Data from Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis. doi:10.1158/0008-5472.c.7075692.v1

DOI
10.1158/0008-5472.c.7075692.v1
Other

Supplementary Data from Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis

Luckett, T., Abudula, M., Ireland, L., Glenn, M., Bellomo, G., Stafferton, R., . . . Mielgo, A. (2024). Supplementary Data from Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis. doi:10.1158/0008-5472.25224576

DOI
10.1158/0008-5472.25224576
Other

Supplementary Data from Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis

Luckett, T., Abudula, M., Ireland, L., Glenn, M., Bellomo, G., Stafferton, R., . . . Mielgo, A. (2024). Supplementary Data from Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis. doi:10.1158/0008-5472.25224576.v1

DOI
10.1158/0008-5472.25224576.v1
Other

Supplementary Figure legends from Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis

Luckett, T., Abudula, M., Ireland, L., Glenn, M., Bellomo, G., Stafferton, R., . . . Mielgo, A. (2024). Supplementary Figure legends from Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis. doi:10.1158/0008-5472.25224573

DOI
10.1158/0008-5472.25224573
Other

Inhibition of insulin-like growth factors increases production of CXCL9/10 by macrophages and fibroblasts and facilitates CD8+ cytotoxic T cell recruitment to pancreatic tumours

Freeman, P., Bellomo, G., Ireland, L., Abudula, M., Luckett, T., Oberst, M., . . . Mielgo, A. (n.d.). Inhibition of insulin-like growth factors increases production of CXCL9/10 by macrophages and fibroblasts and facilitates CD8+ cytotoxic T cell recruitment to pancreatic tumours. Frontiers in Immunology, 15. doi:10.3389/fimmu.2024.1382538

DOI
10.3389/fimmu.2024.1382538
Journal article

2023

PINCER (A Platform Study for solId orgaN CancERs): an agile pan-network platform study to deliver high-quality translational research

Jones, R. P., Mielgo, A., Schmid, M., Bury, D., Andrews, T., Burdak-Rothkamm, S., . . . Vimalachandran, D. (2023). PINCER (A Platform Study for solId orgaN CancERs): an agile pan-network platform study to deliver high-quality translational research. BRITISH JOURNAL OF SURGERY. doi:10.1093/bjs/znad097

DOI
10.1093/bjs/znad097
Journal article

2022

Efficacy of MDX-124, a novel anti-annexin-A1 antibody, in preclinical models of pancreatic cancer

Dempsey, F. C., Al-Ali, H., Crichton, S. J., Fabian, C., Roberts, E., Pepper, C., . . . Parris, C. N. (2022). Efficacy of MDX-124, a novel anti-annexin-A1 antibody, in preclinical models of pancreatic cancer. In JOURNAL OF CLINICAL ONCOLOGY Vol. 40. doi:10.1200/JCO.2022.40.4_suppl.590

DOI
10.1200/JCO.2022.40.4_suppl.590
Conference Paper

2020

2019

2018

F<sub>1</sub>F<sub>0</sub>-ATP Synthase Inhibitory Factor 1 in the Normal Pancreas and in Pancreatic Ductal Adenocarcinoma: Effects on Bioenergetics, Invasion and Proliferation

Tanton, H., Voronina, S., Evans, A., Armstrong, J., Sutton, R., Criddle, D. N., . . . Tepikin, A. V. (2018). F<sub>1</sub>F<sub>0</sub>-ATP Synthase Inhibitory Factor 1 in the Normal Pancreas and in Pancreatic Ductal Adenocarcinoma: Effects on Bioenergetics, Invasion and Proliferation. FRONTIERS IN PHYSIOLOGY, 9. doi:10.3389/fphys.2018.00833

DOI
10.3389/fphys.2018.00833
Journal article

Interfering with MIF-CD74 signalling on macrophages and dendritic cells with a peptide-based approach restores the immune response against metastatic melanoma

DOI
10.1101/248807
Preprint

2017

Macrophage-derived granulin drives resistance to immune checkpoint inhibition in metastatic pancreatic cancer

DOI
10.1101/234906
Preprint

2016

UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis

Abu-Alainin, W., Gana, T., Liloglou, L., Olayanju, A., Barrera Briceno, L., Ferguson, R., . . . Costello-Goldring, E. (2016). UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis. Journal of Pathology, 238(3), 423-433. doi:10.1002/path.4665

DOI
10.1002/path.4665
Journal article

2015

Abstract IA22: Innate immune cell PI3K gamma as a target for suppression of pancreatic ductal adenocarcinoma

Kaneda, M., Hardamon, C., Schmid, M. C., Bouvet, M., Novelli, F., Hirsch, E., . . . Varner, J. A. (2015). Abstract IA22: Innate immune cell PI3K gamma as a target for suppression of pancreatic ductal adenocarcinoma. In Cancer Research Vol. 75 (pp. IA22). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.panca2014-ia22

DOI
10.1158/1538-7445.panca2014-ia22
Conference Paper

UHRF1 regulates the Keap1-Nrf2 cellular defence pathway in pancreatic cancer

Gana, T., Abu-Alainin, W., Liloglou, T., Barrera, L., Campbell, F., Andrews, T., . . . Costello, E. (2015). UHRF1 regulates the Keap1-Nrf2 cellular defence pathway in pancreatic cancer. Pancreatology, 15(3), S29. doi:10.1016/j.pan.2015.05.132

DOI
10.1016/j.pan.2015.05.132
Journal article

2013

PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodes

Garmy-Susini, B., Avraamides, C. J., Desgrosellier, J. S., Schmid, M. C., Foubert, P., Ellies, L. G., . . . Varner, J. (2013). PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(22), 9042-9047. doi:10.1073/pnas.1219603110

DOI
10.1073/pnas.1219603110
Journal article

PI3-Kinase γ Promotes Rap1a-Mediated Activation of Myeloid Cell Integrin α4β1, Leading to Tumor Inflammation and Growth

Schmid, M. C., Franco, I., Kang, S. W., Hirsch, E., Quilliam, L. A., & Varner, J. A. (2013). PI3-Kinase γ Promotes Rap1a-Mediated Activation of Myeloid Cell Integrin α4β1, Leading to Tumor Inflammation and Growth. PLOS ONE, 8(4). doi:10.1371/journal.pone.0060226

DOI
10.1371/journal.pone.0060226
Journal article

Impact of tumour associated macrophages in pancreatic cancer

Mielgo, A., & Schmid, M. C. (2013). Impact of tumour associated macrophages in pancreatic cancer. BMB REPORTS, 46(3), 131-138. doi:10.5483/BMBRep.2013.46.3.036

DOI
10.5483/BMBRep.2013.46.3.036
Journal article

Impact of tumour associated macrophages in pancreatic cancer

Mielgo, A., & Schmid, M. C. (2013). Impact of tumour associated macrophages in pancreatic cancer. BMB Rep, 46(3), 131-138. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/23527856

Journal article

2012

Abstract 411: PI3 Kinase gamma control of Arginase-1 expression promotes tumor immunosuppression

Schmid, M. C., Foubert, P., & Varner, J. A. (2012). Abstract 411: PI3 Kinase gamma control of Arginase-1 expression promotes tumor immunosuppression. Cancer Research, 72(8_Supplement), 411. doi:10.1158/1538-7445.am2012-411

DOI
10.1158/1538-7445.am2012-411
Journal article

Abstract 5228: Inhibition of myeloid cell PI3Kγ is a potential therapeutic approach to treat pancreatic cancer

Hardamon, C. R., Schmid, M. C., Lowy, A. M., Bouvet, M., & Varner, J. A. (2012). Abstract 5228: Inhibition of myeloid cell PI3Kγ is a potential therapeutic approach to treat pancreatic cancer. Cancer Research, 72(8_Supplement), 5228. doi:10.1158/1538-7445.am2012-5228

DOI
10.1158/1538-7445.am2012-5228
Journal article

Caspase-8 isoform 6 promotes death effector filament formation independent of microtubules

Yuan, R. T., Young, S., Liang, J., Schmid, M. C., Mielgo, A., & Stupack, D. G. (2012). Caspase-8 isoform 6 promotes death effector filament formation independent of microtubules. APOPTOSIS, 17(3), 229-235. doi:10.1007/s10495-011-0677-y

DOI
10.1007/s10495-011-0677-y
Journal article

2011

Combined Blockade of Integrin-α4β1 Plus Cytokines SDF-1α or IL-1β Potently Inhibits Tumor Inflammation and Growth

Schmid, M. C., Avraamides, C. J., Foubert, P., Shaked, Y., Kang, S. W., Kerbel, R. S., & Varner, J. A. (2011). Combined Blockade of Integrin-α4β1 Plus Cytokines SDF-1α or IL-1β Potently Inhibits Tumor Inflammation and Growth. CANCER RESEARCH, 71(22), 6965-6975. doi:10.1158/0008-5472.CAN-11-0588

DOI
10.1158/0008-5472.CAN-11-0588
Journal article

Receptor Tyrosine Kinases and TLR/IL1 Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression

Schmid, M. C., Avraamides, C. J., Dippold, H. C., Franco, I., Foubert, P., Ellies, L. G., . . . Varner, J. A. (2011). Receptor Tyrosine Kinases and TLR/IL1 Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression. CANCER CELL, 19(6), 715-727. doi:10.1016/j.ccr.2011.04.016

DOI
10.1016/j.ccr.2011.04.016
Journal article

2010

Integrin α4β1 Signaling Is Required for Lymphangiogenesis and Tumor Metastasis

Garmy-Susini, B., Avraamides, C. J., Schmid, M. C., Foubert, P., Ellies, L. G., Barnes, L., . . . Varner, J. A. (2010). Integrin α4β1 Signaling Is Required for Lymphangiogenesis and Tumor Metastasis. CANCER RESEARCH, 70(8), 3042-3051. doi:10.1158/0008-5472.CAN-09-3761

DOI
10.1158/0008-5472.CAN-09-3761
Journal article

2009

The Death Effector Domains of Caspase-8 Induce Terminal Differentiation

Mielgo, A., Torres, V. A., Schmid, M. C., Graf, R., Zeitlin, S. G., Lee, P., . . . Stupack, D. G. (2009). The Death Effector Domains of Caspase-8 Induce Terminal Differentiation. PLOS ONE, 4(11). doi:10.1371/journal.pone.0007879

DOI
10.1371/journal.pone.0007879
Journal article

Circulating endothelial progenitor cells.

Schmid, M. C., & Varner, J. A. (2009). Circulating endothelial progenitor cells.. Methods in molecular biology (Clifton, N.J.), 467, 139-155. doi:10.1007/978-1-59745-241-0_8

DOI
10.1007/978-1-59745-241-0_8
Journal article

The Death Effector Domains of Caspase-8 Induce Terminal Differentiation

Mielgo, A., Torres, V. A., Schmid, M. C., Graf, R., Zeitlin, S. G., Lee, P., . . . Stupack, D. G. (n.d.). The Death Effector Domains of Caspase-8 Induce Terminal Differentiation. PLoS ONE, 4(11), e7879. doi:10.1371/journal.pone.0007879

DOI
10.1371/journal.pone.0007879
Journal article

2008

METHODS TO STUDY MYELOID CELL ROLES IN ANGIOGENESIS

Schmid, M. C., & Varner, J. A. (2008). METHODS TO STUDY MYELOID CELL ROLES IN ANGIOGENESIS. ANGIOGENESIS: IN VIVO SYSTEMS, PT B, 445, 343-371. doi:10.1016/S0076-6879(08)03015-2

DOI
10.1016/S0076-6879(08)03015-2
Journal article

2007

Myeloid cell trafficking and tumor angiogenesis

Schmid, M. C., & Varner, J. A. (2007). Myeloid cell trafficking and tumor angiogenesis. CANCER LETTERS, 250(1), 1-8. doi:10.1016/j.canlet.2006.09.002

DOI
10.1016/j.canlet.2006.09.002
Journal article

2006

A translocated bacterial protein protects vascular endothelial cells from apoptosis

Schmid, M. C., Scheidegger, F., Dehio, M., Balmelle-Devaux, N., Schulein, R., Guye, P., . . . Dehio, C. (2006). A translocated bacterial protein protects vascular endothelial cells from apoptosis. PLOS PATHOGENS, 2(11), 1083-1097. doi:10.1371/journal.ppat.0020115

DOI
10.1371/journal.ppat.0020115
Journal article

2005

A bipartite signal mediates the transfer of type IV secretion substrates of <i>Bartonella henselae</i> into human cells

Schulein, R., Guye, P., Rhomberg, T. A., Schmid, M. C., Schröder, G., Vergunst, A. C., . . . Dehio, C. (2005). A bipartite signal mediates the transfer of type IV secretion substrates of <i>Bartonella henselae</i> into human cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(3), 856-861. doi:10.1073/pnas.0406796102

DOI
10.1073/pnas.0406796102
Journal article

2004

The VirB type IV secretion system of <i>Bartonella henselae</i> mediates invasion, proinflammatory activation and antiapoptotic protection of endothelial cells

Schmid, M. C., Schulein, R., Dehio, M., Denecker, G., Carena, I., & Dehio, C. (2004). The VirB type IV secretion system of <i>Bartonella henselae</i> mediates invasion, proinflammatory activation and antiapoptotic protection of endothelial cells. MOLECULAR MICROBIOLOGY, 52(1), 81-92. doi:10.1111/j.1365-2958.2003.03964.x

DOI
10.1111/j.1365-2958.2003.03964.x
Journal article

2003

Insulin-like growth factor binding protein-3 is overexpressed in endothelial cells of mouse breast tumor vessels

Schmid, M. C., Bisoffi, M., Wetterwald, A., Gautschi, E., Thalmann, G. N., Mitola, S., . . . Cecchini, M. G. (2003). Insulin-like growth factor binding protein-3 is overexpressed in endothelial cells of mouse breast tumor vessels. INTERNATIONAL JOURNAL OF CANCER, 103(5), 577-586. doi:10.1002/ijc.10874

DOI
10.1002/ijc.10874
Journal article

2000

Intussusceptive angiogenesis - Its role in embryonic vascular network formation

Djonov, V., Schmid, M., Tschanz, S. A., & Burri, P. H. (2000). Intussusceptive angiogenesis - Its role in embryonic vascular network formation. CIRCULATION RESEARCH, 86(3), 286-292. doi:10.1161/01.RES.86.3.286

DOI
10.1161/01.RES.86.3.286
Journal article