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Michael Beresford

Professor Michael Beresford
MBChB MRCP(UK) MRCPCH PhD

Brough Chair, Professor of Child Health, Honorary Consultant Paediatric Rheumatologist
Women's & Children's Health

Research

Professor of Child Health

He is Director of the UK’s only ‘Experimental Arthritis Treatment Centre for Children’ supported by Versus Arthritis and the ‘NIHR Alder Hey Clinical Research Facility for Experimental Medicine’.
He is Executive member of the Paediatric Rheumatology European Society and Chair of the Paediatric Rheumatology Committee of the European Alliance of Associations for Rheumatology (EULAR). He developed and leads an internationally renowned Childhood Lupus translational research programme as part of the LUPUS UK’s Centre of Excellence for Childhood Lupus.

Experimental Arthritis Treatment Centre for Children

He is Director of the UK’s only Experimental Arthritis Treatment Centre for Children and Clinical Director of the NIHR Alder Hey Clinical Research Facility for Experimental Medicine.

He was Chair of the NIHR CRN: Children/Arthritis Research UK Paediatric Rheumatology Clinical Study Group, responsible for developing and overseeing a UK wide comprehensive portfolio of clinical trials and related studies covering the entire spectrum of diseases in paediatric rheumatology.

Juvenile-onset SLE

Professor Beresford Chairs the UK JSLE Study Group and has developed an internationally recognized Childhood Lupus translational research programme as part of the UK’s only Centre of Excellence for Childhood Lupus.

Research grants

Steroid TreAtment TRial in JIA: a randomised trial to compare effectiveness, safety and cost-effectiveness of oral versus intravenous corticosteroid induction regimens for children and young people with juvenile idiopathic arthritis (STAR-JIA)

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

January 2023 - December 2026

Understanding immune cell:tissue interactions in lupus nephritis: A pathway to target-directed interventions

MERCK LTD (UK)

November 2023 - October 2025

Establishing microbiota-host interactions in seronegative inflammatory arthritis across age groups

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

June 2023 - May 2024

Improving Access to Care in Juvenile-onset SLE: Speeding up time to diagnosis

LUPUS UK (UK)

September 2023 - December 2024

Micro-RNAs as biomarkers and new molecular targets in systemic lupus erythematosus (SLE)

ALDER HEY CHILDREN'S CHARITY (UK)

October 2021 - September 2022

CRF Director Support

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

April 2017 - August 2022

MCRN Pain and Palliative Care Clinical Studies Group

GREAT ORMOND STREET HOSPITAL CHILDRENS CHARITY (UK)

January 2012 - March 2021

Childhood arthritis and its associated uveitis: stratification through endotypes and mechanism to deliver benefit; the CLUSTER Consortium

ABBVIE LTD (UK), MEDICAL RESEARCH COUNCIL, SWEDISH ORPHAN BIOVITRUM AG (SOBI) - (SWEDEN)

July 2018 - July 2024

NIHR Alder Hey CRF - PPIE-associated consumables

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

April 2018 - August 2027

Children Growing up in Liverpool (C-GULL)

WELLCOME TRUST (UK)

October 2020 - December 2029

Delivering Paediatric Clinical Pharmacology in Experimental Medicine and Early Phase Trials

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

April 2018 - March 2023

Delivering Paediatric Clinical Pharmacology in Experimental Medicine and Early Phase Trials in partnership with Industry

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

April 2017 - August 2022

Clinical Research Fellow (RCF) in Experimental Medicine

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

August 2018 - July 2020

Clinical Research Fellow (CRF) in Experimental Medicine

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

August 2018 - July 2020

Alder Hey - Clinical Research Facility

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

April 2017 - August 2027

Elicitation of expert prior opinion for a future Bayesian randomised controlled trial for a rare inflammatory paediatric disease, Juvenile Localised Scleroderma (JLS)

RAYNAUD'S & SCLERODERMA ASSOCIATION (UK)

December 2018 - March 2020

COllaborative Network for European Clinical Trials For Children (Conect4Children, C4C)

EUROPEAN COMMISSION

May 2018 - April 2025

NIHR ARC 2 national social care implementation projects

DEPARTMENT OF HEALTH & SOCIAL CARE (UK), LCCG - LIVERPOOL CLINICAL COMMISSIONING GROUP (UK)

October 2019 - March 2026

NIHR CRN: Children/BSPED Diabetes and Endocrinology Clinical Study Group

DIABETES UK (UK)

January 2017 - December 2019

YEAH: Youngsters EngAgement in Health Science

EUROPEAN INSTITUTE OF INNOVATION AND TECHNOLOGY (EIT) (HUNGARY)

January 2020 - December 2021

NIHR CRN Alliance funding for Liverpool CRN Theme office

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

April 2016 - March 2020

Clinical studies group in paediatric rheumatology.

ARTHRITIS RESEARCH UK, VERSUS ARTHRITIS (UK)

April 2016 - December 2023

A Randomised Controlled Trial of adalimumab versus pamidronate in Chronic Recurrent Multifocal Osteomyelitis (CRMO) using a Bayesian Design

ARTHRITIS RESEARCH UK

June 2016 - March 2021

Supporting translational research in Paediatric Rheumatology and Respiratory

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

March 2016 - April 2024

MAximizing Sle ThERapeutic PotentiaL by Application of Novel and Stratified approaches (MASTERPLANS)

MEDICAL RESEARCH COUNCIL

June 2015 - February 2021

Steroid Induction Regimen for Juvenile Idiopathic Arthritis (SIRJIA)

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

January 2016 - March 2019

Lupus UK and British Paediatric Surveillance Unit study of the incidence and prevalence of Juvenile-onset Systemic Lupus Erythematosus in children and young people in the UK and Republic of Ireland

LUPUS UK (UK)

April 2016 - September 2021

CRN Children-Pharmacy & Formulations Work Stream

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

April 2015 - March 2016

A phase II trial of tocilizumab in anti-TNF refractory patients with JIA associated uvetis

ARTHRITIS RESEARCH UK

February 2015 - March 2020

Clinical Studies Group Chair in Paediatric Rheumatology.

ARTHRITIS RESEARCH UK

October 2014 - March 2016

Paediatric Clinical Research Facility

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

April 2015 - March 2018

British Orthopaedic SCFE Surgery (BOSS) Study Investigating Slipped Capital Femoral Epiphysis (SCFE) as a childhood precursor to osteoarthritis

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

March 2015 - May 2020

The interactions of Type I & II Interferons with Neutrophils; contributions to autoimmune disease pathogenesis and potential therapeutic modifications

LUPUS UK (UK)

November 2013 - October 2014

Childhood Arthritis Response to Treatment consortium (CHART): partnership to define stratified medicine tools for childhood inflammatory arthritis

MEDICAL RESEARCH COUNCIL

July 2014 - June 2018

NIHR Medicines for Children Research Network

ACTION MEDICAL RESEARCH (UK), BRITISH ASSOCIATION FOR PAEDIATRIC NEPHROLOGY (UK), DEPARTMENT OF HEALTH & SOCIAL CARE (UK), GAUCHERS ASSOCIATION (UK), KING'S COLLEGE LONDON (UK)

April 2010 - March 2017

Identifying and targeting immune pathways leading to the expression of renal biomarkers in juvenile lupus

ALDER HEY CHILDREN'S KIDNEY FUND (UK)

September 2013 - December 2019

Specialist Clinical Psychologist in Childhood Lupus

LUPUS UK (UK)

April 2014 - March 2018

Investigating immunopathogenesis of JSLE

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

April 2013 - May 2014

NIHR Alder Hey CRF: Experimental Medicine and Clinical Pharmacology

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

January 2013 - July 2013

Clinical Fellow in Paediatric and Neonatal Clinical Trials

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

February 2012 - July 2013

CRF Clinical Research Fellow

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

May 2015 - December 2018

Tracking cancer and mortality in UK Children and Young People with Lupus

LUPUS UK (UK)

September 2014 - February 2025

The role of the inflammatory cytokine interleukin 1 in Juvenile-onset Lupus Nephritis

ALDER HEY CHILDREN'S CHARITY (UK)

October 2013 - December 2016

MYPAN: Open label randomised controlled trial of mycophenolate mofetil versus cyclphoshamide for the induction of remission of childhood polyarteritis nodosa

ARTHRITIS RESEARCH UK

July 2013 - April 2020

2009 BSPAR annual scientific meeting

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

January 2010 - August 2014

Clinical Fellow in Paediatric and Neonatal Clinical Trials

THE CHESHIRE AND MERSEYSIDE COMPREHENSIVE LOCAL RESEARCH NETWORK (UK)

April 2013 - December 2015

Setting up a European reference network for uniform treatment of rare paediatric Immune Mediated Inflammatory Diseases (IMID)

EUROPEAN COMMISSION

September 2012 - December 2015

Metfizz

EUROPEAN COMMISSION

October 2013 - March 2017

Validation of a composite disease activity score for juvenile idiopathic arthritis (JADAS) for use in a clinical setting and as a predictor of outcome

ARTHRITIS RESEARCH UK

August 2010 - December 2012

Administrative support for Professor Beresford

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

April 2014 - March 2015

The role of Toll like receptors in Juvenile Systemic Lupus Erythematosus

ASSOCIATION OF PHYSICIANS OF GREAT BRITAIN AND IRELAND

September 2009 - August 2010

Flexibility and Sustainability Funding for Lucy Ballentine

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

January 2012 - December 2012

Investigating Biomarkers in Juvenile-onset Lupus Nephritis

ALDER HEY CHILDREN'S KIDNEY FUND (UK)

August 2009 - July 2013

Clinical Studies Group Chair in Paediatric Rheumatology.

ARTHRITIS RESEARCH CAMPAIGN, ARTHRITIS RESEARCH UK

October 2007 - September 2014

BPSU Behcet’s Study

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK), BEHCET'S SYNDROME SOCIETY (UK), THE UK VASCULITIS TRUST (UK)

December 2014 - December 2019

UK JSLE Conhort study & repository: Phase 2

LUPUS UK (UK)

November 2012 - December 2016

Use of dried blood spots to measure methotrexate polyglutamates as biomarkers of methotrexate use in paedriatric patients with juvenile Idiopathic Arthritis (JIA) and Juvenile Dermatomyostitis.

ARTHRITIS RESEARCH UK

June 2010 - July 2013

Investigating the serum effects on apoptosis in Juvenile Systemic Lupus Erythematosus (JSLE)

LUPUS UK (UK)

July 2010 - July 2013

Investigating neutrophil function in juvenile onset systemic lupus erythematosus.

ARTHRITIS RESEARCH CAMPAIGN

April 2007 - March 2008

Experimental Arthritis Treatment Centre (EATC) for Childhood Arthritis

ALDER HEY CHILDREN'S CHARITY (UK), ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK), ARTHRITIS RESEARCH UK, VERSUS ARTHRITIS (UK)

April 2014 - February 2026

TINN Trial EU FP7

EUROPEAN COMMISSION

November 2008 - October 2015

Lupus travel grant

ALDER HEY CHILDREN'S KIDNEY FUND (UK)

December 2014 - December 2019

A study of factors involved in phagocytosis in Juvenile Onset Systemic Lupus Erythematosus during periods of disease flare and quiescence

WELLCOME TRUST (UK)

July 2013 - September 2013

NIHR AlderHey CRF-­ Senior Lecturer in Clinical Pharmacology

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

April 2013 - March 2019

Development of an Internationally agreed Minimal Dataset for Juvenile Dermatomyositis (JDM); a rare but severe, potentially life-threatening, childhood rheumatological condition

ARTHRITIS RESEARCH UK

January 2014 - June 2017

Feasibility study for an RCT to evaluate an intervention for parents early in the diagnosis of juvenile idiopathic arthritis.

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

January 2013 - September 2015

    Research collaborations

    CAPS Steering Committee

    ARC epidemiology Unit, Manchester University

    Principal Investigator

    Dr N Wilkinson

    Nuffield Orthopaedic Centre, Oxford

    UK JSLE Registry

    Dr J Davidson

    The University of Glasgow

    UK JSLE registry

    Professor S Edwards

    Joint grant applications with a view to developing research program in juvenile onset SLE and paediatric rheumatology. This was successful with a £64K grant awarded to investigate neutrophil function in JSLE

    Dr H Foster

    The University of Newcastle-upon-Tyne

    Collaborative research: development of national research program exploring clinical characteristics and immunopathology of JSLE

    Dr N McHugh

    The University of Bath

    Collaborative research: development of national research program exploring clinical characteristics and immunopathology of JSLE

    Dr H Venning

    The University of Nottingham

    Collaborative research: development of national research program exploring clinical characteristics and immunopathology of JSLE

    Dr C Pilkington

    Institute of Child Health, London

    JLSE Registry and Repository

    Steering Committee

    Institute of Child Health, London

    Steering Committee member of UK JDM R&R

    Professor D Isenberg

    University College London

    Collaborative research: development of national research program exploring clinical characteristics and immunopathology of JSLE

    Professor R Moots

    Joint grant applications and close collaboration in developing strong links between the Department of Paediatric Rheumatology and the extensive program of clinical and basic science research. Application for grants were successful with an award of £64K for invesitgating neutrophil function in JSLE

    Dr E Baildam

    The University of Manchester

    Collaborative research: development of national research program exploring clinical characteristics and immunopathology of JSLE

    Dr J McDonagh

    The University of Birmingham

    Collaborative research: development of national research program exploring clinical characteristics and immunopathology of JSLE