Research
Alterations of metabolism are a hallmark of cancer. It has been shown that tumours display a deep metabolic reprogramming, often orchestrated by activation of oncogenic signalling, that sustains the biosynthetic needs of cancer cells and their aberrant proliferation. Some of these alterations are shared by different tumour types while others are distinctive of specific tumour subtypes or stages of progression. In our laboratory, we are interested in identifying the key metabolic pathways reprogrammed at different stages of tumour progression, how they are orchestrated, their impact on the malignant features of cancer cells, uncovering the role of metabolites as signalling molecules in cancer.