Publications
Selected publications
- Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression (Journal article - 2022)
- The context-specific roles of urea cycle enzymes in tumorigenesis (Journal article - 2021)
- Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses (Journal article - 2021)
- Metabolic Drivers in Hereditary Cancer Syndromes (Book - 2020)
- Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells (Journal article - 2018)
- Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects (Journal article - 2017)
- Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition (Journal article - 2016)
- The Mitochondrial Chaperone TRAP1 Promotes Neoplastic Growth by Inhibiting Succinate Dehydrogenase (Journal article - 2013)
2024
KRAS G12 mutant alleles differentially control glutamine metabolism via FOXO1
Corrigendum to "Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells" [Metabol. Eng. 45 (2018) 149-157].
Gonçalves, E., Sciacovelli, M., Costa, A. S. H., Tran, M. G. B., Johnson, T. I., Machado, D., . . . Saez-Rodriguez, J. (2024). Corrigendum to "Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells" [Metabol. Eng. 45 (2018) 149-157].. Metabolic engineering, 82, 297-298. doi:10.1016/j.ymben.2024.01.002
2023
FOXA2 controls the anti-oxidant response in FH-deficient cells
Rogerson, C., Sciacovelli, M., Maddalena, L. A., Pouikli, A., Segarra-Mondejar, M., Valcarcel-Jimenez, L., . . . Frezza, C. (2023). FOXA2 controls the anti-oxidant response in FH-deficient cells. CELL REPORTS, 42(7). doi:10.1016/j.celrep.2023.112751
2022
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression
Sciacovelli, M., Dugourd, A., Jimenez, L. V., Yang, M., Nikitopoulou, E., Costa, A. S. H., . . . Frezza, C. (2022). Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-35036-4
2021
The context-specific roles of urea cycle enzymes in tumorigenesis
Hajaj, E., Sciacovelli, M., Frezza, C., & Erez, A. (2021). The context-specific roles of urea cycle enzymes in tumorigenesis. MOLECULAR CELL, 81(18), 3749-3759. doi:10.1016/j.molcel.2021.08.005
Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
Bodineau, C., Tome, M., Courtois, S., Costa, A. S. H., Sciacovelli, M., Rousseau, B., . . . Duran, R. V. (2021). Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-25079-4
Low P66shc with High SerpinB3 Levels Favors Necroptosis and Better Survival in Hepatocellular Carcinoma
Fasolato, S., Ruvoletto, M., Nardo, G., Rasola, A., Sciacovelli, M., Zanus, G., . . . Pontisso, P. (2021). Low P66shc with High SerpinB3 Levels Favors Necroptosis and Better Survival in Hepatocellular Carcinoma. BIOLOGY-BASEL, 10(5). doi:10.3390/biology10050363
Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells
Sant'Anna-Silva, A. C. B., Perez-Valencia, J. A., Sciacovelli, M., Lalou, C., Sarlak, S., Tronci, L., . . . Klocker, H. (2021). Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells. CANCERS, 13(7). doi:10.3390/cancers13071727
Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses
Dugourd, A., Kuppe, C., Sciacovelli, M., Gjerga, E., Gabor, A., Emdal, K. B., . . . Saez-Rodriguez, J. (2021). Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses. MOLECULAR SYSTEMS BIOLOGY, 17(1). doi:10.15252/msb.20209730
2020
Metabolic Drivers in Hereditary Cancer Syndromes
Sciacovelli, M., Schmidt, C., Maher, E. R., & Frezza, C. (2020). Metabolic Drivers in Hereditary Cancer Syndromes (Vol. 4). doi:10.1146/annurev-cancerbio-030419-033612
Fumarate hydratase in cancer: A multifaceted tumour suppressor
Schmidt, C., Sciacovelli, M., & Frezza, C. (2020). Fumarate hydratase in cancer: A multifaceted tumour suppressor. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 98, 15-25. doi:10.1016/j.semcdb.2019.05.002
2018
Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells
Goncalves, E., Sciacovelli, M., Costa, A. S. H., Tran, M. G. B., Johnson, T. I., Machado, D., . . . Saez-Rodriguez, J. (2018). Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells. METABOLIC ENGINEERING, 45, 149-157. doi:10.1016/j.ymben.2017.11.011
2017
Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects
Tyrakis, P. A., Yurkovich, M. E., Sciacovelli, M., Papachristou, E. K., Bridges, H. R., Gaude, E., . . . Frezza, C. (2017). Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects. CELL REPORTS, 21(4), 1036-1047. doi:10.1016/j.celrep.2017.09.092
Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer
Sciacovelli, M., & Frezza, C. (2017). Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer. FEBS JOURNAL, 284(19), 3132-3144. doi:10.1111/febs.14090
Mutations in mitochondrial DNA causing tubulointerstitial kidney disease
Connor, T. M., Hoer, S., Mallett, A., Gale, D. P., Gomez-Duran, A., Posse, V., . . . Maxwell, P. H. (2017). Mutations in mitochondrial DNA causing tubulointerstitial kidney disease. PLOS GENETICS, 13(3). doi:10.1371/journal.pgen.1006620
Fumarate drives EMT in renal cancer
Sciacovelli, M., & Frezza, C. (2017). Fumarate drives EMT in renal cancer. CELL DEATH AND DIFFERENTIATION, 24(1), 1-2. doi:10.1038/cdd.2016.137
2016
Oncometabolites: Unconventional triggers of oncogenic signalling cascades
Sciacovelli, M., & Frezza, C. (2016). Oncometabolites: Unconventional triggers of oncogenic signalling cascades. FREE RADICAL BIOLOGY AND MEDICINE, 100, 175-181. doi:10.1016/j.freeradbiomed.2016.04.025
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
Sciacovelli, M., Goncalves, E., Johnson, T. I., Zecchini, V. R., da Costa, A. S. H., Gaude, E., . . . Frezza, C. (2016). Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition. NATURE, 537(7621), 544-+. doi:10.1038/nature19353
2015
Fumarate induces redox-dependent senescence by modifying glutathione metabolism
Zheng, L., Cardaci, S., Jerby, L., MacKenzie, E. D., Sciacovelli, M., Johnson, T. I., . . . Gottlieb, E. (2015). Fumarate induces redox-dependent senescence by modifying glutathione metabolism. NATURE COMMUNICATIONS, 6. doi:10.1038/ncomms7001
2014
Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells
Guzzo, G., Sciacovelli, M., Bernardi, P., & Rasola, A. (2014). Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells. ONCOTARGET, 5(23), 11897-11908. doi:10.18632/oncotarget.2472
Germline <i>FH</i> Mutations Presenting With Pheochromocytoma
Clark, G. R., Sciacovelli, M., Gaude, E., Walsh, D. M., Kirby, G., Simpson, M. A., . . . Maher, E. R. (2014). Germline <i>FH</i> Mutations Presenting With Pheochromocytoma. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 99(10), E2046-E2050. doi:10.1210/jc.2014-1659
SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I
Ciscato, F., Sciacovelli, M., Villano, G., Turato, C., Bernardi, P., Rasola, A., & Pontisso, P. (2014). SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I. ONCOTARGET, 5(9), 2418-2427. doi:10.18632/oncotarget.1411
The Metabolic Alterations of Cancer Cells
Sciacovelli, M., Gaude, E., Hilvo, M., & Frezza, C. (2014). The Metabolic Alterations of Cancer Cells. In CONCEPTUAL BACKGROUND AND BIOENERGETIC/MITOCHONDRIAL ASPECTS OF ONCOMETABOLISM (Vol. 542, pp. 1-23). doi:10.1016/B978-0-12-416618-9.00001-7
2013
The Mitochondrial Chaperone TRAP1 Promotes Neoplastic Growth by Inhibiting Succinate Dehydrogenase
Sciacovelli, M., Guzzo, G., Morello, V., Frezza, C., Zheng, L., Nannini, N., . . . Rasola, A. (2013). The Mitochondrial Chaperone TRAP1 Promotes Neoplastic Growth by Inhibiting Succinate Dehydrogenase. CELL METABOLISM, 17(6), 988-999. doi:10.1016/j.cmet.2013.04.019
2012
Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death.
Chiara, F., Gambalunga, A., Sciacovelli, M., Nicolli, A., Ronconi, L., Fregona, D., . . . Trevisan, A. (2012). Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death.. Cell death & disease, 3, e444. doi:10.1038/cddis.2012.184
2011
Antamanide, a Derivative of <i>Amanita phalloides</i>, Is a Novel Inhibitor of the Mitochondrial Permeability Transition Pore
Azzolin, L., Antolini, N., Calderan, A., Ruzza, P., Sciacovelli, M., Marin, O., . . . Rasola, A. (2011). Antamanide, a Derivative of <i>Amanita phalloides</i>, Is a Novel Inhibitor of the Mitochondrial Permeability Transition Pore. PLOS ONE, 6(1). doi:10.1371/journal.pone.0016280
2010
Signal transduction to the permeability transition pore
Rasola, A., Sciacovelli, M., Pantic, B., & Bernardi, P. (2010). Signal transduction to the permeability transition pore. FEBS LETTERS, 584(10), 1989-1996. doi:10.1016/j.febslet.2010.02.022
Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition
Rasola, A., Sciacovelli, M., Chiara, F., Pantic, B., Brusilow, W. S., & Bernardi, P. (2010). Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(2), 726-731. doi:10.1073/pnas.0912742107