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2024

2023

C1GalT1 expression reciprocally controls tumour cell-cell and tumour-macrophage interactions mediated by galectin-3 and MGL with double impact on cancer development and progression.

Wan, Y., Adair, K., Herrmann, A., Shan, X., Xia, L., Duckworth, C. A., & Yu, L. -G. (2023). C1GalT1 expression reciprocally controls tumour cell-cell and tumour-macrophage interactions mediated by galectin-3 and MGL with double impact on cancer development and progression.. Cell death & disease, 14(8), 547. doi:10.1038/s41419-023-06082-7

DOI
10.1038/s41419-023-06082-7
Journal article

2022

2021

Appearance of peanut agglutinin in the blood circulation after peanut ingestion promotes endothelial secretion of metastasis-promoting cytokines

Wang, W., Sindrewicz-Goral, P., Chen, C., Duckworth, C. A., Pritchard, D. M., Rhodes, J. M., & Yu, L. -G. (2021). Appearance of peanut agglutinin in the blood circulation after peanut ingestion promotes endothelial secretion of metastasis-promoting cytokines. CARCINOGENESIS, 42(8), 1079-1088. doi:10.1093/carcin/bgab059

DOI
10.1093/carcin/bgab059
Journal article

2020

DHPAC, a novel microtubule depolymerizing agent, suppresses angiogenesis and vasculogenic mimicry formation of human non-small cell lung cancer

Gong, F. -L., Wang, L., Yu, L. -G., Dang, Y. -F., Jiang, X. -N., Zhao, L., & Guo, X. -L. (2020). DHPAC, a novel microtubule depolymerizing agent, suppresses angiogenesis and vasculogenic mimicry formation of human non-small cell lung cancer. JOURNAL OF CELLULAR BIOCHEMISTRY, 121(12), 4756-4771. doi:10.1002/jcb.29690

DOI
10.1002/jcb.29690
Journal article

Serum galectins as potential biomarkers of inflammatory bowel diseases

Yu, T. B., Dodd, S., Yu, L. -G., & Subramanian, S. (2020). Serum galectins as potential biomarkers of inflammatory bowel diseases. PLOS ONE, 15(1). doi:10.1371/journal.pone.0227306

DOI
10.1371/journal.pone.0227306
Journal article

2019

INFLAMMTORY BOWEL DISEASE PATIENTS EXPRESS HIGHER LEVELS OF CIRCULATING GALECTINS-1 AND-3 THAN HEALTHY PEOPLE

Subramanian, S., Yu, T., Dodd, S., & Yu, L. (2019). INFLAMMTORY BOWEL DISEASE PATIENTS EXPRESS HIGHER LEVELS OF CIRCULATING GALECTINS-1 AND-3 THAN HEALTHY PEOPLE. In GUT Vol. 68 (pp. A103). doi:10.1136/gutjnl-2019-BSGAbstracts.195

DOI
10.1136/gutjnl-2019-BSGAbstracts.195
Conference Paper

Investigation of galectin-3 interactions with novel binding ligands for the development of anti-cancer therapeutic agents

Sindrewicz-Goral, P. (2019). Investigation of galectin-3 interactions with novel binding ligands for the development of anti-cancer therapeutic agents.

DOI
10.17638/03087343
Thesis / Dissertation

2018

Endogenous and exogenous galectin-3 promote the adhesion of tumor cells with low expression of MUC1 to HUVECs through upregulation of N-cadherin and CD44

Cao, Z., Hao, Z., Xin, M., Yu, L., Wang, L., Zhang, Y., . . . Guo, X. (2018). Endogenous and exogenous galectin-3 promote the adhesion of tumor cells with low expression of MUC1 to HUVECs through upregulation of N-cadherin and CD44. Laboratory Investigation, 98, 1642-1656. doi:10.1038/s41374-018-0119-3

DOI
10.1038/s41374-018-0119-3
Journal article

2017

DHPAC, a novel synthetic microtubule destabilizing agent, possess high anti-tumor activity in vincristine-resistant oral epidermoid carcinoma <i>in vitro</i> and <i>in vivo</i>

Zhang, Y., Gong, F. -L., Lu, Z. -N., Wang, H. -Y., Cheng, Y. -N., Liu, Z. -P., . . . Guo, X. -L. (2017). DHPAC, a novel synthetic microtubule destabilizing agent, possess high anti-tumor activity in vincristine-resistant oral epidermoid carcinoma <i>in vitro</i> and <i>in vivo</i>. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 93, 1-11. doi:10.1016/j.biocel.2017.10.012

DOI
10.1016/j.biocel.2017.10.012
Journal article

MUC1 O-glycosylation contributes to anoikis resistance in epithelial cancer cells.

Piyush, T., Rhodes, J. M., & Yu, L. G. (2017). MUC1 O-glycosylation contributes to anoikis resistance in epithelial cancer cells. Cell Death Discovery, 3. doi:10.1038/cddiscovery.2017.44

DOI
10.1038/cddiscovery.2017.44
Journal article

Galectin-3 interacts with the cell surface glycoprotein CD146 (MCAM, MUC18) and induces secretion of metastasis-promoting cytokines from vascular endothelial cells

Colomb, F., Wang, W., Simpson, D., Zafar, M., Beynon, R., Rhodes, J. M., & Yu, L. G. (2017). Galectin-3 interacts with the cell surface glycoprotein CD146 (MCAM, MUC18) and induces secretion of metastasis-promoting cytokines from vascular endothelial cells. Journal of Biological Chemistry, 292(20), 8381-8389. doi:10.1074/jbc.M117.783431

DOI
10.1074/jbc.M117.783431
Journal article

2016

2015

Molecular mechanism of anticancer effect of <i>Sclerotium rolfsii</i> lectin in HT29 cells involves differential expression of genes associated with multiple signaling pathways: A microarray analysis

Barkeer, S., Guha, N., Hothpet, V., Adavigowda, D. S., Hegde, P., Padmanaban, A., . . . Inamdar, S. R. (2015). Molecular mechanism of anticancer effect of <i>Sclerotium rolfsii</i> lectin in HT29 cells involves differential expression of genes associated with multiple signaling pathways: A microarray analysis. GLYCOBIOLOGY, 25(12), 1375-1391. doi:10.1093/glycob/cwv067

DOI
10.1093/glycob/cwv067
Journal article

Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis

Duckworth, C. A., Guimond, S. E., Sindrewicz, P., Hughes, A. J., French, N. S., Lian, L. -Y., . . . Yu, L. -G. (2015). Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis. ONCOTARGET, 6(27), 23671-23687. doi:10.18632/oncotarget.4409

DOI
10.18632/oncotarget.4409
Journal article

Antitumor lectin Sclerotium rolfsii (SRL) induces apoptosis in human colon cancer cells by activation of multiple signaling pathways; A microarray analysis

Barkeer, S., Guha, N., Vishwanathreddy, H., Deepak, S. A., Anupama, S., Padmanaban, A., . . . Inamdar, S. R. (2015). Antitumor lectin Sclerotium rolfsii (SRL) induces apoptosis in human colon cancer cells by activation of multiple signaling pathways; A microarray analysis. Translational Biomedicine, 6(Special Issue), 1-12. Retrieved from http://www.transbiomedicine.com/

Journal article

2014

Sclerotium rolfsii Lectin Induces Stronger Inhibition of Proliferation in Human Breast Cancer Cells than Normal Human Mammary Epithelial Cells by Induction of Cell Apoptosis

Savanur, M. A., Eligar, S. M., Pujari, R., Chen, C., Mahajan, P., Borges, A., . . . Inamdar, S. R. (n.d.). Sclerotium rolfsii Lectin Induces Stronger Inhibition of Proliferation in Human Breast Cancer Cells than Normal Human Mammary Epithelial Cells by Induction of Cell Apoptosis. PLoS ONE, 9(11), e110107. doi:10.1371/journal.pone.0110107

DOI
10.1371/journal.pone.0110107
Journal article

Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galactin-3 to promote metastasis by interaction with cancer-associated MUC1

Zhao, Q., Duckworth, C. A., Wang, W. K., Guo, X., Barrow, H., Pritchard, D. M., . . . Yu, L. G. (2014). Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galactin-3 to promote metastasis by interaction with cancer-associated MUC1. Carcinogenesis, 35(12), 2815-2821. doi:10.1093/carcin/bgu216

DOI
10.1093/carcin/bgu216
Journal article

Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galectin-3 to promote metastasis by interaction with cancer-associated MUC1

Zhao, Q., Duckworth, C. A., Wang, W., Guo, X., Barrow, H., Pritchard, D. M., . . . Yu, L. -G. (2014). Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galectin-3 to promote metastasis by interaction with cancer-associated MUC1. Carcinogenesis, 35(12), 2815-2821. doi:10.1093/carcin/bgu216

DOI
10.1093/carcin/bgu216
Journal article

<i>Sclerotium rolfsii</i> Lectin Induces Stronger Inhibition of Proliferation in Human Breast Cancer Cells than Normal Human Mammary Epithelial Cells by Induction of Cell Apoptosis

Savanur, M. A., Eligar, S. M., Pujari, R., Chen, C., Mahajan, P., Borges, A., . . . Inamdar, S. R. (2014). <i>Sclerotium rolfsii</i> Lectin Induces Stronger Inhibition of Proliferation in Human Breast Cancer Cells than Normal Human Mammary Epithelial Cells by Induction of Cell Apoptosis. PLOS ONE, 9(11). doi:10.1371/journal.pone.0110107

DOI
10.1371/journal.pone.0110107
Journal article

MUC1 extracellular domain contributes to resistance of epithelial cancer cells to anoikis

Zhao, Q., Piyush, T., Chen, C., Hollingsworth, M. A., Hilkens, J., Rhodes, J. M., & Yu, L. G. (2014). MUC1 extracellular domain contributes to resistance of epithelial cancer cells to anoikis. Cell Death & Disease, 5(e1438). doi:10.1038/cddis.2014.421

DOI
10.1038/cddis.2014.421
Journal article

SRL lectin induced apoptosis of human colon cancer cells: identification of pathways leading to cell death (589.1)

Guha, N., SA, D., Barkeer, S., KS, A., Rhodes, J., Yu, L. G., . . . Inamdar, S. (2014). SRL lectin induced apoptosis of human colon cancer cells: identification of pathways leading to cell death (589.1). The FASEB Journal, 28(S1). doi:10.1096/fasebj.28.1_supplement.589.1

DOI
10.1096/fasebj.28.1_supplement.589.1
Journal article

Circulating galectins-2,-4 and-8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis

Chen, C., Duckworth, C. A., Fu, B., Pritchard, D. M., Rhodes, J. M., & Yu, L. -G. (2014). Circulating galectins-2,-4 and-8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis. BRITISH JOURNAL OF CANCER, 110(3), 741-752. doi:10.1038/bjc.2013.793

DOI
10.1038/bjc.2013.793
Journal article

A Tetramethylpyrazine Piperazine Derivate CXC137 Prevents Cell Injury in SH-SY5Y Cells and Improves Memory Dysfunction of Rats with Vascular Dementia

Zhang, H., Sun, R., Liu, X. -Y., Shi, X. -M., Wang, W. -F., Yu, L. -G., & Guo, X. -L. (2014). A Tetramethylpyrazine Piperazine Derivate CXC137 Prevents Cell Injury in SH-SY5Y Cells and Improves Memory Dysfunction of Rats with Vascular Dementia. NEUROCHEMICAL RESEARCH, 39(2), 276-286. doi:10.1007/s11064-013-1219-5

DOI
10.1007/s11064-013-1219-5
Journal article

Circulating galectins -2, -4 and -8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis

Chen, C., Duckworth, C. A., Fu, B., Pritchard, D. M., Rhodes, J. M., & Yu, L. G. (2014). Circulating galectins -2, -4 and -8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis. Br J Cancer, 110(3), 741-752. doi:10.1038/bjc.2013.793

DOI
10.1038/bjc.2013.793
Journal article

2013

Increased Circulation of Galectin-3 in Cancer Induces Secretion of Metastasis-Promoting Cytokines from Blood Vascular Endothelium

Chen, C., Duckworth, C. A., Zhao, Q., Pritchard, D. M., Rhodes, J. M., & Yu, L. -G. (2013). Increased Circulation of Galectin-3 in Cancer Induces Secretion of Metastasis-Promoting Cytokines from Blood Vascular Endothelium. CLINICAL CANCER RESEARCH, 19(7), 1693-1704. doi:10.1158/1078-0432.CCR-12-2940

DOI
10.1158/1078-0432.CCR-12-2940
Journal article

Suppression of Core 1 Gal-Transferase Is Associated with Reduction of TF and Reciprocal Increase of Tn, sialyl-Tn and Core 3 Glycans in Human Colon Cancer Cells

Barrow, H., Tam, B., Duckworth, C. A., Rhodes, J. M., & Yu, L. -G. (2013). Suppression of Core 1 Gal-Transferase Is Associated with Reduction of TF and Reciprocal Increase of Tn, sialyl-Tn and Core 3 Glycans in Human Colon Cancer Cells. PLOS ONE, 8(3). doi:10.1371/journal.pone.0059792

DOI
10.1371/journal.pone.0059792
Journal article

ASSAY

YU, L. -G. (2013). ASSAY.

Patent

6r, a novel oxadiazole analogue of ethacrynic acid, exhibits antitumor activity both in vitro and in vivo by induction of cell apoptosis and S-phase arrest.

Zhang, P., Chen, J. -H., Dong, X., Tang, M. -T., Gao, L. -Y., Zhao, G. -S., . . . Guo, X. -L. (2013). 6r, a novel oxadiazole analogue of ethacrynic acid, exhibits antitumor activity both in vitro and in vivo by induction of cell apoptosis and S-phase arrest.. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 67(1), 58-65. doi:10.1016/j.biopha.2012.10.011

DOI
10.1016/j.biopha.2012.10.011
Journal article

Simultaneous determination of serum galectin-3 and -4 levels detects metastases in colorectal cancer patients.

Barrow, H., Rhodes, J. M., & Yu, L. -G. (2013). Simultaneous determination of serum galectin-3 and -4 levels detects metastases in colorectal cancer patients.. Cellular oncology (Dordrecht, Netherlands), 36(1), 9-13. doi:10.1007/s13402-012-0109-1

DOI
10.1007/s13402-012-0109-1
Journal article

Galectins in the blood circulation: potential therapeutic targets of cancer metastasis

Duckworth, C. A., & Yu, L. G. (2013). Galectins in the blood circulation: potential therapeutic targets of cancer metastasis. ACS, 115, 310-322.

Journal article

Glycosylation Change in Cancer as Therapeutic Target: Opportunities and Challenges

Yu, L. -G. (n.d.). Glycosylation Change in Cancer as Therapeutic Target: Opportunities and Challenges. Journal of Glycobiology, s1. doi:10.4172/2168-958x.s1-e001

DOI
10.4172/2168-958x.s1-e001
Journal article

Inhibition of PTEN expression and activity by angiotensin II induces proliferation and migration of vascular smooth muscle cells.

Dong, X., Yu, L. -G., Sun, R., Cheng, Y. -N., Cao, H., Yang, K. -M., . . . Guo, X. -L. (2013). Inhibition of PTEN expression and activity by angiotensin II induces proliferation and migration of vascular smooth muscle cells.. Journal of cellular biochemistry, 114(1), 174-182. doi:10.1002/jcb.24315

DOI
10.1002/jcb.24315
Journal article

2012

Galectins in the Blood Circulation: Potential Therapeutic Targets of Cancer Metastasis

Duckworth, C. A., & Yu, L. -G. (2012). Galectins in the Blood Circulation: Potential Therapeutic Targets of Cancer Metastasis. In Unknown Book (Vol. 1115, pp. 309-+). Retrieved from https://www.webofscience.com/

Chapter

The TF-antigen binding lectin from <i>Sclerotium rolfsii</i> inhibits growth of human colon cancer cells by inducing apoptosis in vitro and suppresses tumor growth in vivo

Inamdar, S. R., Savanur, M. A., Eligar, S. M., Chachadi, V. B., Nagre, N. N., Chen, C., . . . Yu, L. -G. (2012). The TF-antigen binding lectin from <i>Sclerotium rolfsii</i> inhibits growth of human colon cancer cells by inducing apoptosis in vitro and suppresses tumor growth in vivo. GLYCOBIOLOGY, 22(9), 1227-1235. doi:10.1093/glycob/cws090

DOI
10.1093/glycob/cws090
Journal article

The TF-antigen binding lectin from Sclerotium rolfsii inhibits growth of human colon cancer cells by inducing apoptosis in vitro and suppresses tumor growth in vivo

Inamdar, S. R., Savanur, M. A., Eligar, S. M., Chachadi, V. B., Nagre, N. N., Chen, C., . . . Yu, L. -G. (2012). The TF-antigen binding lectin from Sclerotium rolfsii inhibits growth of human colon cancer cells by inducing apoptosis in vitro and suppresses tumor growth in vivo. Glycobiology, 22(9), 1227-1235. doi:10.1093/glycob/cws090

DOI
10.1093/glycob/cws090
Journal article

GALECTIN-3 INDUCES SECRETION OF CYTOKINES FROM VASCULAR ENDOTHELIUM THAT ENHANCE CANCER CELL-ENDOTHELIUM ADHESION: A NOVEL MECHANISM FOR GALECTIN-3-MEDIATED METASTASIS PROMOTION

Chen, C., Zhao, Q., Rhodes, J. M., & Yu, L. G. (2012). GALECTIN-3 INDUCES SECRETION OF CYTOKINES FROM VASCULAR ENDOTHELIUM THAT ENHANCE CANCER CELL-ENDOTHELIUM ADHESION: A NOVEL MECHANISM FOR GALECTIN-3-MEDIATED METASTASIS PROMOTION. In GUT Vol. 61 (pp. A109-A110). doi:10.1136/gutjnl-2012-302514b.90

DOI
10.1136/gutjnl-2012-302514b.90
Conference Paper

Sorcin, a potential therapeutic target for reversing multidrug resistance in cancer.

Zheng, B. -B., Zhang, P., Jia, W. -W., Yu, L. -G., & Guo, X. -L. (2012). Sorcin, a potential therapeutic target for reversing multidrug resistance in cancer.. Journal of physiology and biochemistry, 68(2), 281-287. doi:10.1007/s13105-011-0140-0

DOI
10.1007/s13105-011-0140-0
Journal article

2011

Galectin-3--a jack-of-all-trades in cancer.

Newlaczyl, A. U., & Yu, L. -G. (2011). Galectin-3--a jack-of-all-trades in cancer.. Cancer letters, 313(2), 123-128. doi:10.1016/j.canlet.2011.09.003

DOI
10.1016/j.canlet.2011.09.003
Journal article

Serum Galectin-2, -4, and -8 Are Greatly Increased in Colon and Breast Cancer Patients and Promote Cancer Cell Adhesion to Blood Vascular Endothelium

Barrow, H., Guo, X., Wandall, H. H., Pedersen, J. W., Fu, B., Zhao, Q., . . . Yu, L. -G. (2011). Serum Galectin-2, -4, and -8 Are Greatly Increased in Colon and Breast Cancer Patients and Promote Cancer Cell Adhesion to Blood Vascular Endothelium. Clinical Cancer Research, 17(22), 7035-7046. doi:10.1158/1078-0432.ccr-11-1462

DOI
10.1158/1078-0432.ccr-11-1462
Journal article

Serum Galectin-2,-4, and -8 Are Greatly Increased in Colon and Breast Cancer Patients and Promote Cancer Cell Adhesion to Blood Vascular Endothelium

Barrow, H., Guo, X., Wandall, H. H., Pedersen, J. W., Fu, B., Zhao, Q., . . . Yu, L. -G. (2011). Serum Galectin-2,-4, and -8 Are Greatly Increased in Colon and Breast Cancer Patients and Promote Cancer Cell Adhesion to Blood Vascular Endothelium. CLINICAL CANCER RESEARCH, 17(22), 7035-7046. doi:10.1158/1078-0432.CCR-11-1462

DOI
10.1158/1078-0432.CCR-11-1462
Journal article

The role of galectins in colorectal cancer progression.

Barrow, H., Rhodes, J. M., & Yu, L. -G. (2011). The role of galectins in colorectal cancer progression.. International journal of cancer, 129(1), 1-8. doi:10.1002/ijc.25945

DOI
10.1002/ijc.25945
Journal article

Ligustrazine derivate DLJ14 reduces multidrug resistance of K562/A02 cells by modulating GSTπ activity.

Song, Y. -N., Guo, X. -L., Zheng, B. -B., Liu, X. -Y., Dong, X., Yu, L. -G., & Cheng, Y. -N. (2011). Ligustrazine derivate DLJ14 reduces multidrug resistance of K562/A02 cells by modulating GSTπ activity.. Toxicology in vitro : an international journal published in association with BIBRA, 25(4), 937-943. doi:10.1016/j.tiv.2011.03.002

DOI
10.1016/j.tiv.2011.03.002
Journal article

ASSAY

YU, L. -G. (2011). ASSAY.

Patent

Exquisite binding specificity of Sclerotium rolfsii lectin toward TF-related O-linked mucin-type glycans.

Chachadi, V. B., Inamdar, S. R., Yu, L. -G., Rhodes, J. M., & Swamy, B. M. (2011). Exquisite binding specificity of Sclerotium rolfsii lectin toward TF-related O-linked mucin-type glycans.. Glycoconjugate journal, 28(1), 49-56. doi:10.1007/s10719-011-9323-8

DOI
10.1007/s10719-011-9323-8
Journal article

2010

Regulation and role of organic anion-transporting polypeptides (OATPs) in drug delivery at the choroid plexus.

Zhang, H., Song, Y. -N., Liu, W. -G., Guo, X. -L., & Yu, L. -G. (2010). Regulation and role of organic anion-transporting polypeptides (OATPs) in drug delivery at the choroid plexus.. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 17(6), 679-684. doi:10.1016/j.jocn.2009.11.001

DOI
10.1016/j.jocn.2009.11.001
Journal article

Circulating galectin-3 in the bloodstream: An emerging promoter of cancer metastasis

Yu, L. -G. (2010). Circulating galectin-3 in the bloodstream: An emerging promoter of cancer metastasis. World Journal of Gastrointestinal Oncology, 2(4), 177. doi:10.4251/wjgo.v2.i4.177

DOI
10.4251/wjgo.v2.i4.177
Journal article

Effect of O-glycosylation and sialylation inhibitors on classical NLS-dependent protein import

Tam, B., Rhodes, J. M., & Yu, L. G. (2010). Effect of O-glycosylation and sialylation inhibitors on classical NLS-dependent protein import. Glycobiology Insights, 2, 75-82.

Journal article

Glycosylation and Disease

Rhodes, J. M., Campbell, B. J., & Yu, L. G. (2010). Glycosylation and Disease. Encyclopaedia of Life Sciences, 2nd ed.

Journal article

Glycosylation and Disease

Rhodes, J. M., Campbell, B. J., & Yu, L. G. (2010). Glycosylation and Disease. In Macmillan Reference Ltd.London (Ed.), Encyclopaedia of Life Sciences. (pp. 1-15). London: Macmillan Reference Ltd.,.

Chapter

Mechanism of tetramethylpyrazine analogue CXC195 inhibition of hydrogen peroxide-induced apoptosis in human endothelial cells.

Ou, Y., Dong, X., Liu, X. -Y., Cheng, X. -C., Cheng, Y. -N., Yu, L. -G., & Guo, X. -L. (2010). Mechanism of tetramethylpyrazine analogue CXC195 inhibition of hydrogen peroxide-induced apoptosis in human endothelial cells.. Biological & pharmaceutical bulletin, 33(3), 432-438. doi:10.1248/bpb.33.432

DOI
10.1248/bpb.33.432
Journal article

2009

Circulating Galectin-3 Promotes Metastasis by Modifying MUC1 Localization on Cancer Cell Surface

Zhao, Q., Guo, X., Nash, G. B., Stone, P. C., Hilkens, J., Rhodes, J. M., & Yu, L. -G. (2009). Circulating Galectin-3 Promotes Metastasis by Modifying MUC1 Localization on Cancer Cell Surface. Cancer Research, 69(17), 6799-6806. doi:10.1158/0008-5472.can-09-1096

DOI
10.1158/0008-5472.can-09-1096
Journal article

T1988 Circulating Galactoside-Binding Galectins Are Highly Elevated in Colorectal Cancer Patients with Liver Metastasis and Promote Cancer Cell Adhesion to Huvecs

Barrow, H., Rhodes, J. M., & Yu, L. -G. (2009). T1988 Circulating Galactoside-Binding Galectins Are Highly Elevated in Colorectal Cancer Patients with Liver Metastasis and Promote Cancer Cell Adhesion to Huvecs. Gastroenterology, 136(5), A-615. doi:10.1016/s0016-5085(09)62835-3

DOI
10.1016/s0016-5085(09)62835-3
Journal article

2008

Lectin-epithelial interactions in the human colon

Rhodes, J. M., Campbell, B. J., & Yu, L. -G. (2008). Lectin-epithelial interactions in the human colon. BIOCHEMICAL SOCIETY TRANSACTIONS, 36, 1482-1486. doi:10.1042/BST0361482

DOI
10.1042/BST0361482
Journal article

Plagiochin E, a botanic-derived phenolic compound, reverses fungal resistance to fluconazole relating to the efflux pump.

Guo, X. -L., Leng, P., Yang, Y., Yu, L. -G., & Lou, H. -X. (2008). Plagiochin E, a botanic-derived phenolic compound, reverses fungal resistance to fluconazole relating to the efflux pump.. Journal of applied microbiology, 104(3), 831-838. doi:10.1111/j.1365-2672.2007.03617.x

DOI
10.1111/j.1365-2672.2007.03617.x
Journal article

2007

The oncofetal Thomsen-Friedenreich carbohydrate antigen in cancer progression.

Yu, L. -G. (2007). The oncofetal Thomsen-Friedenreich carbohydrate antigen in cancer progression.. Glycoconjugate journal, 24(8), 411-420. doi:10.1007/s10719-007-9034-3

DOI
10.1007/s10719-007-9034-3
Journal article

Galectin-3 interaction with Thomsen-Friedenreich disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion.

Yu, L. -G., Andrews, N., Zhao, Q., McKean, D., Williams, J. F., Connor, L. J., . . . Rhodes, J. M. (2007). Galectin-3 interaction with Thomsen-Friedenreich disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion.. The Journal of biological chemistry, 282(1), 773-781. doi:10.1074/jbc.m606862200

DOI
10.1074/jbc.m606862200
Journal article

Mucosal glycocojugates in inflammatory bowel disease and colon cancer

Campbell, B. J., Yu, L. G., & Rhodes, J. M. (2007). Mucosal glycocojugates in inflammatory bowel disease and colon cancer. In C. Sansom, & O. Markman (Eds.), Glycobiology (pp. in press). London: Scion Publishing Ltd.

Chapter

2004

Protein phosphatase 2A, a negative regulator of the ERK signaling pathway, is activated by tyrosine phosphorylation of putative HLA class II-associated protein I (PHAPI)/pp32 in response to the antiproliferative lectin, jacalin.

Yu, L. -G., Packman, L. C., Weldon, M., Hamlett, J., & Rhodes, J. M. (2004). Protein phosphatase 2A, a negative regulator of the ERK signaling pathway, is activated by tyrosine phosphorylation of putative HLA class II-associated protein I (PHAPI)/pp32 in response to the antiproliferative lectin, jacalin.. The Journal of biological chemistry, 279(40), 41377-41383. doi:10.1074/jbc.m400017200

DOI
10.1074/jbc.m400017200
Journal article

2003

Edible mushroom (Agaricus bisporus) lectin inhibits human retinal pigment epithelial cell proliferation in vitro

Kent, D., Sheridan, C. M., Tomkinson, H. A., White, S. J., Hiscott, P., Yu, L., & Grierson, I. (2003). Edible mushroom (Agaricus bisporus) lectin inhibits human retinal pigment epithelial cell proliferation in vitro. WOUND REPAIR AND REGENERATION, 11(4), 285-291. doi:10.1046/j.1524-475X.2003.11408.x

DOI
10.1046/j.1524-475X.2003.11408.x
Journal article

Phosphorylation of PHAPI is a key event in the regulation of protein phosphatase 2A and hence of downstream mitogenic signalling in HT29 human colon cancer cells

Yu, L. -G., Packman, L. C., Weldon, M., & Rhodes, J. M. (2003). Phosphorylation of PHAPI is a key event in the regulation of protein phosphatase 2A and hence of downstream mitogenic signalling in HT29 human colon cancer cells. Gastroenterology, 124(4), A280. doi:10.1016/s0016-5085(03)81406-3

DOI
10.1016/s0016-5085(03)81406-3
Journal article

Altered glycosylation in inflammatory bowel disease: A possible role in cancer development

Campbell, B. J., Yu, L. G., & Rhodes, J. M. (2003). Altered glycosylation in inflammatory bowel disease: A possible role in cancer development. Glycoconj J, 18(11-12), 851-858. Retrieved from http://springerlink.metapress.com/

Journal article

Edible mushroom (Agaricus bisporus) lectin inhibits human retinal pigment epithelial cell proliferation in vitro

Kent, D., Sheridan, C. M., Tomkinson, H. A., White, S. J., Hiscott, P., Yu, L., & Grierson, I. (2003). Edible mushroom (Agaricus bisporus) lectin inhibits human retinal pigment epithelial cell proliferation in vitro. Wound Repair and Regen, 11(4), 285-291. doi:10.1046/j.1524-475X.2003.11408.x

DOI
10.1046/j.1524-475X.2003.11408.x
Journal article

2002

An N-terminal truncated form of Orp150 is a cytoplasmic ligand for the anti-proliferative mushroom Agaricus bisporus lectin and is required for nuclear localization sequence-dependent nuclear protein import.

Yu, L. -G., Andrews, N., Weldon, M., Gerasimenko, O. V., Campbell, B. J., Singh, R., . . . Rhodes, J. M. (2002). An N-terminal truncated form of Orp150 is a cytoplasmic ligand for the anti-proliferative mushroom Agaricus bisporus lectin and is required for nuclear localization sequence-dependent nuclear protein import.. The Journal of biological chemistry, 277(27), 24538-24545. doi:10.1074/jbc.m203550200

DOI
10.1074/jbc.m203550200
Journal article

An N-terminal truncated form of Orp150 is a cytoplasmic ligand for the anti-proliferative edible mushroom Agaricus bisporus lectin and is required for NLS-dependent nuclear protein import

Yu, L. G., Andrews, N., Weldon, M., Gerasimenko, O. V., Campbel, B. J., Grierson, I., . . . Rhodes, J. M. (2002). An N-terminal truncated form of Orp150 is a cytoplasmic ligand for the anti-proliferative edible mushroom Agaricus bisporus lectin and is required for NLS-dependent nuclear protein import. Biochemical Society Transactions, 30(1), A30. doi:10.1042/bst030a030

DOI
10.1042/bst030a030
Journal article

2001

Altered glycosylation in inflammatory bowel disease: A possible role in cancer development

Campbell, B. J., Yu, L. G., & Rhodes, J. M. (2001). Altered glycosylation in inflammatory bowel disease: A possible role in cancer development. GLYCOCONJUGATE JOURNAL, 18(11-12), 851-858. doi:10.1023/A:1022240107040

DOI
10.1023/A:1022240107040
Journal article

Interaction between bacterial peptides, neutrophils and goblet cells: a possible mechanism for neutrophil recruitment and goblet cell depletion in colitis

Leiper, K., Campbell, B. J., Jenkinson, M. D., Milton, J., Yu, L. G., Democratis, J., & Rhodes, J. M. (2001). Interaction between bacterial peptides, neutrophils and goblet cells: a possible mechanism for neutrophil recruitment and goblet cell depletion in colitis. CLINICAL SCIENCE, 101(4), 395-402. doi:10.1042/CS20010078

DOI
10.1042/CS20010078
Journal article

Interaction between bacterial peptides, neutrophils and goblet cells: a possible mechanism for neutrophil recruitment and goblet cell depletion in colitis

LEIPER, K., CAMPBELL, B. J., JENKINSON, M. D., MILTON, J., YU, L. -G., DEMOCRATIS, J., & RHODES, J. M. (2001). Interaction between bacterial peptides, neutrophils and goblet cells: a possible mechanism for neutrophil recruitment and goblet cell depletion in colitis. Clinical Science, 101(4), 395. doi:10.1042/cs20010078

DOI
10.1042/cs20010078
Journal article

Expression of Schwann cell-specific proteins and low-molecular-weight neurofilament protein during regeneration of sciatic nerve treated with neurotrophin-4

Yin, Q., Kemp, G. J., Yu, L. G., Wagstaff, S. C., & Frostick, S. P. (2001). Expression of Schwann cell-specific proteins and low-molecular-weight neurofilament protein during regeneration of sciatic nerve treated with neurotrophin-4. NEUROSCIENCE, 105(3), 779-783. doi:10.1016/S0306-4522(01)00216-0

DOI
10.1016/S0306-4522(01)00216-0
Journal article

Cell surface-expressed Thomsen-Friedenreich antigen in colon cancer is predominantly carried on high molecular weight splice variants of CD44

Singh, R., Campbell, B. J., Yu, L. G., Fernig, D. G., Milton, J. D., Goodlad, R., . . . Rhodes, J. M. (2001). Cell surface-expressed Thomsen-Friedenreich antigen in colon cancer is predominantly carried on high molecular weight splice variants of CD44. GLYCOBIOLOGY, 11(7), 587-592. doi:10.1093/glycob/11.7.587

DOI
10.1093/glycob/11.7.587
Journal article

Neurotrophin-4 delivered by fibrin glue promotes peripheral nerve regeneration.

Yin, Q., Kemp, G. J., Yu, L. G., Wagstaff, S. C., & Frostick, S. P. (2001). Neurotrophin-4 delivered by fibrin glue promotes peripheral nerve regeneration.. Muscle & nerve, 24(3), 345-351. doi:3.0.co;2-p">10.1002/1097-4598(200103)24:3<345::aid-mus1004>3.0.co;2-p

DOI
10.1002/1097-4598(200103)24:3<345::aid-mus1004>3.0.co;2-p
Journal article

Neurotrophin-4 delivered by fibrin glue promotes peripheral nerve regeneration

Yin, Q., Kemp, G. J., Yu, L. G., Wagstaff, S. C., & Frostrick, S. P. (2001). Neurotrophin-4 delivered by fibrin glue promotes peripheral nerve regeneration. MUSCLE & NERVE, 24(3), 345-351. doi:3.3.CO;2-G">10.1002/1097-4598(200103)24:3<345::AID-MUS1004>3.3.CO;2-G

DOI
10.1002/1097-4598(200103)24:3<345::AID-MUS1004>3.3.CO;2-G
Journal article

Opposite effects on human colon cancer cell proliferation of two dietary Thomsen-Friedenreich antigen-binding lectins

Yu, L. G., Milton, J. D., Fernig, D. G., & Rhodes, J. M. (2001). Opposite effects on human colon cancer cell proliferation of two dietary Thomsen-Friedenreich antigen-binding lectins. JOURNAL OF CELLULAR PHYSIOLOGY, 186(2), 282-287. doi:3.0.CO;2-2">10.1002/1097-4652(200102)186:2<282::AID-JCP1028>3.0.CO;2-2

DOI
10.1002/1097-4652(200102)186:2<282::AID-JCP1028>3.0.CO;2-2
Journal article

Opposite effects on human colon cancer cell proliferation of two dietary Thomsen-Friedenreich antigen-binding lectins.

Yu, L. G., Milton, J. D., Fernig, D. G., & Rhodes, J. M. (2001). Opposite effects on human colon cancer cell proliferation of two dietary Thomsen-Friedenreich antigen-binding lectins.. Journal of cellular physiology, 186(2), 282-287. doi:3.0.co;2-2">10.1002/1097-4652(200102)186:2<282::aid-jcp1028>3.0.co;2-2

DOI
10.1002/1097-4652(200102)186:2<282::aid-jcp1028>3.0.co;2-2
Journal article

Altered glycosylation in inflammatory bowel disease: A possible role in cancer development

Campbell, B. J., Yu, L. G., & Rhodes, J. M. (2001). Altered glycosylation in inflammatory bowel disease: A possible role in cancer development. Unknown Journal, 18, 851-858.

Journal article

Expression of Schwann cell specific proteins and low molecular weight neurofilament protein during regeneration of sciatic nerve treated with neurotrophin-4

Yin, Q., Kemp, G. J., Yu, L. G., Wagstaff, S. C., & Frostick, S. P. (2001). Expression of Schwann cell specific proteins and low molecular weight neurofilament protein during regeneration of sciatic nerve treated with neurotrophin-4. Neuroscience, 105(3), 779-783.

Journal article

Interaction between bacterial peptides, neutrophils and goblet cells: a possible mechanism for neutrophil recruitment and goblet cell depletion in colitis

Leiper, K., Campbell, B. J., Jenkinson, M. D., Milton, J. D., Yu, L. G., Demoncratis, J., & Rhodes, J. M. (2001). Interaction between bacterial peptides, neutrophils and goblet cells: a possible mechanism for neutrophil recruitment and goblet cell depletion in colitis. Clin Sci, 101(4), 395-402.

Journal article

Opposite effects on human colon cancer cell proliferation of two dietary Thomsen-Friedenreich antigen-binding lectins

Yu, L. G., Milton, J. D., Fernig, D. G., & Rhodes, J. M. (2001). Opposite effects on human colon cancer cell proliferation of two dietary Thomsen-Friedenreich antigen-binding lectins. J Cell Physiol, 186(2), 282-287. doi:3.0.CO;2-2">10.1002/1097-4652(200102)186:2<282::AID-JCP1028>3.0.CO;2-2

DOI
10.1002/1097-4652(200102)186:2<282::AID-JCP1028>3.0.CO;2-2
Journal article

2000

Intracellular trafficking and release of intact edible mushroom lectin from HT29 human colon cancer cells

Yu, L. G., Fernig, D. G., & Rhodes, J. M. (2000). Intracellular trafficking and release of intact edible mushroom lectin from HT29 human colon cancer cells. EUROPEAN JOURNAL OF BIOCHEMISTRY, 267(7), 2122-2126. doi:10.1046/j.1432-1327.2000.01230.x

DOI
10.1046/j.1432-1327.2000.01230.x
Journal article

Identification of intracellular galactose-expressing glycoproteins in human colon cancer cells, possible ligands for galectins.

Yu, L. G., Campbell, B. J., Singh, R., & Rhodes, J. M. (2000). Identification of intracellular galactose-expressing glycoproteins in human colon cancer cells, possible ligands for galectins.. GASTROENTEROLOGY, 118(4), A603. doi:10.1016/S0016-5085(00)84553-9

DOI
10.1016/S0016-5085(00)84553-9
Journal article

Peanut lectin-induced proliferation of HT29 human colon cancer cells is mediated by activation of nitrogen-activated protein kinase (MAPK).

Singh, R., Yu, L. G., Fernig, D. G., Delehedde, M., Campbell, B. J., & Rhodes, J. M. (2000). Peanut lectin-induced proliferation of HT29 human colon cancer cells is mediated by activation of nitrogen-activated protein kinase (MAPK).. In GASTROENTEROLOGY Vol. 118 (pp. A614). doi:10.1016/S0016-5085(00)84595-3

DOI
10.1016/S0016-5085(00)84595-3
Conference Paper

TNF-A decreases the sulphation of mucins and CD44 in human colonic epithelial cells; An effect which may explain the low mucosal sulphation seen in inflammatory bowel disease.

Campbell, B. J., Oxley, C., Singh, R., Yu, L. G., & Rhodes, J. M. (2000). TNF-A decreases the sulphation of mucins and CD44 in human colonic epithelial cells; An effect which may explain the low mucosal sulphation seen in inflammatory bowel disease.. GASTROENTEROLOGY, 118(4), A701. doi:10.1016/S0016-5085(00)84935-5

DOI
10.1016/S0016-5085(00)84935-5
Journal article

Glycosylation and Disease

Rhodes, J., & Yu, L. (n.d.). Glycosylation and Disease. Wiley. doi:10.1038/npg.els.0002151

DOI
10.1038/npg.els.0002151
Chapter

Glycosylation and Disease

Rhodes, J., Campbell, B. J., & Yu, L. (n.d.). Glycosylation and Disease. doi:10.1002/9780470015902.a0002151.pub2

DOI
10.1002/9780470015902.a0002151.pub2
Journal article

1999

Modulation of retinal pigment epithelial cell behavior by <i>Agaricus bisporus</i> lectin

Wenkel, H., Kent, D., Hiscott, P., Batterbury, M., Groenewald, C., Sheridan, C. M., . . . Milton, J. (1999). Modulation of retinal pigment epithelial cell behavior by <i>Agaricus bisporus</i> lectin. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 40(12), 3058-3062. Retrieved from https://www.webofscience.com/

Journal article

Edible mushroom (<i>Agaricus bisporus</i>) lectin, which reversibly inhibits epithelial cell proliferation, blocks nuclear localization sequence-dependent nuclear protein import

Yu, L. G., Fernig, D. G., White, M. R. H., Spiller, D. G., Appleton, P., Evans, R. C., . . . Rhodes, J. M. (1999). Edible mushroom (<i>Agaricus bisporus</i>) lectin, which reversibly inhibits epithelial cell proliferation, blocks nuclear localization sequence-dependent nuclear protein import. JOURNAL OF BIOLOGICAL CHEMISTRY, 274(8), 4890-4899. doi:10.1074/jbc.274.8.4890

DOI
10.1074/jbc.274.8.4890
Journal article

Agaricus bisporus lectin modulates retinal pigment epithelial cell behavior

Wenkel, H., Kent, D., Hiscott, P., Batterbury, M., Groenewalk, C., Sheridan, C. M., . . . Milton, J. D. (1999). Agaricus bisporus lectin modulates retinal pigment epithelial cell behavior. Invest Ophthalmol Vis Sci, 40(12), 3058-3062.

Journal article

1998

Identification of intact peanut lectin in peripheral venous blood

Wang, Q., Yu, L. G., Campbell, B. J., Milton, J. D., & Rhodes, J. M. (1998). Identification of intact peanut lectin in peripheral venous blood. LANCET, 352(9143), 1831-1832. doi:10.1016/S0140-6736(05)79894-9

DOI
10.1016/S0140-6736(05)79894-9
Journal article

Identification of intact peanut lectin in peripheral venous blood after peanut ingestion

Wang, Q., Yu, L. G., Campbell, B. J., Milton, J. D., & Rhodes, J. M. (1998). Identification of intact peanut lectin in peripheral venous blood after peanut ingestion. Lancet, 352(9143), 1831-1832.

Journal article

Mitogenic effects of lectins on epithelial cells.

Yu, L. G., & Rhodes, J. M. (1998). Mitogenic effects of lectins on epithelial cells.. In Unknown Book (Vol. 9, pp. 379-384). doi:10.1385/0-89603-396-1:379

DOI
10.1385/0-89603-396-1:379
Chapter

1997

Stimulation of proliferation in human colon cancer cells by human monoclonal antibodies against the TF antigen (galactose beta 1-3 N-acetyl-galactosamine)

Yu, L. G., Jansson, B., Fernig, D. G., Milton, J. D., Smith, J. A., Gerasimenko, O. V., . . . Rhodes, J. M. (1997). Stimulation of proliferation in human colon cancer cells by human monoclonal antibodies against the TF antigen (galactose beta 1-3 N-acetyl-galactosamine). INTERNATIONAL JOURNAL OF CANCER, 73(3), 424-431. doi:3.0.CO;2-C">10.1002/(SICI)1097-0215(19971104)73:3<424::AID-IJC18>3.0.CO;2-C

DOI
10.1002/(SICI)1097-0215(19971104)73:3<424::AID-IJC18>3.0.CO;2-C
Journal article

1996

Stimulation of colonic mucin synthesis by corticosteroids and nicotine

Finnie, I. A., Campbell, B. J., Taylor, B. A., Milton, J. D., Sadek, S. K., Yu, L. G., & Rhodes, J. M. (1996). Stimulation of colonic mucin synthesis by corticosteroids and nicotine. CLINICAL SCIENCE, 91(3), 359-364. doi:10.1042/cs0910359

DOI
10.1042/cs0910359
Journal article

Effect of corticosteroids and nicotine on colonic mucin synthesis

Finnie, I. A., Campbell, B. J., Taylor, B. A., Milton, J. D., Sadek, S. K., Yu, L. G., & Rhodes, J. M. (1996). Effect of corticosteroids and nicotine on colonic mucin synthesis. Clin Sci, 91(3), 359-364.

Journal article

1995

Demonstration of Internalization and Nuclear Incorporation of the Growth Inhibitory Lectin from Edible Mushroom

Yu, L. G., Evans, R. C., Davies, H., Ward, S., Miller, G., Grierson, I., . . . Rhodes, J. M. (1995). Demonstration of Internalization and Nuclear Incorporation of the Growth Inhibitory Lectin from Edible Mushroom. Clinical Science, 88(s32), 11P. doi:10.1042/cs088011pa

DOI
10.1042/cs088011pa
Journal article

1993

REVERSIBLE INHIBITION OF PROLIFERATION OF EPITHELIAL-CELL LINES BY AGARICUS-BISPORUS (EDIBLE MUSHROOM) LECTIN

YU, L. G., FERNIG, D. G., SMITH, J. A., MILTON, J. D., & RHODES, J. M. (1993). REVERSIBLE INHIBITION OF PROLIFERATION OF EPITHELIAL-CELL LINES BY AGARICUS-BISPORUS (EDIBLE MUSHROOM) LECTIN. CANCER RESEARCH, 53(19), 4627-4632. Retrieved from https://www.webofscience.com/

Journal article

Reversible inhibition of proliferation of epithelial cell lines by Agaricus bisporus (edible mushroom) lectin

Yu, L., Fernig, D. G., Smith, J. A., Milton, J. D., & Rhodes, J. M. (1993). Reversible inhibition of proliferation of epithelial cell lines by Agaricus bisporus (edible mushroom) lectin. Cancer Res, 53, 534627-534632.

Journal article