Publications
Selected publications
- Cryptococcal meningoencephalitis: time for action (Journal article - 2021)
- Population Pharmacokinetics and Pharmacodynamics of Itraconazole for Disseminated Infection Caused by Talaromyces marneffei. (Journal article - 2021)
- THE PHARMACOKINETICS AND PHARMACODYNAMICS OF ANTIFUNGAL AGENTS FOR HIV-ASSOCIATED INVASIVE FUNGAL INFECTIONS (Thesis / Dissertation - 2021)
- Pharmacokinetics-pharmacodynamics of antifungal agents in the central nervous system (Journal article - 2018)
- Population Pharmacokinetics and Cerebrospinal Fluid Penetration of Fluconazole in Adults with Cryptococcal Meningitis (Journal article - 2018)
- Population Pharmacokinetic Model and Meta-analysis of Outcomes of Amphotericin B Deoxycholate Use in Adults with Cryptococcal Meningitis (Journal article - 2018)
- Therapeutic drug monitoring for invasive mould infections and disease: pharmacokinetic and pharmacodynamic considerations (Journal article - 2017)
2024
Integration of genomic and pharmacokinetic data to predict clinical outcomes in HIV-associated cryptococcal meningitis.
Stott, K. E., Mohabir, J. T., Bowers, K., Tenor, J. L., Toffaletti, D. L., Unsworth, J., . . . AMBITION Study Group. (2024). Integration of genomic and pharmacokinetic data to predict clinical outcomes in HIV-associated cryptococcal meningitis.. mBio, e0159224. doi:10.1128/mbio.01592-24
Challenges for global antibiotic regimen planning and establishing antimicrobial resistance targets: implications for the WHO Essential Medicines List and AWaRe antibiotic book dosing.
Reza, N., Gerada, A., Stott, K. E., Howard, A., Sharland, M., & Hope, W. (2024). Challenges for global antibiotic regimen planning and establishing antimicrobial resistance targets: implications for the WHO Essential Medicines List and AWaRe antibiotic book dosing.. Clinical microbiology reviews, 37(2), e0013923. doi:10.1128/cmr.00139-23
Development and validation of quantitative PCR assays for HIV-associated cryptococcal meningitis in sub-Saharan Africa: a diagnostic accuracy study
Mbangiwa, T., Sturny-Leclère, A., Lechiile, K., Kajanga, C., Boyer-Chammard, T., Hoving, J. C., . . . Muyise, R. (2024). Development and validation of quantitative PCR assays for HIV-associated cryptococcal meningitis in sub-Saharan Africa: a diagnostic accuracy study. The Lancet Microbe. doi:10.1016/S2666-5247(23)00362-2
2023
Pharmacodynamics of ATI-2307 in a rabbit model of cryptococcal meningoencephalitis.
Giamberardino, C. D., Tenor, J. L., Toffaletti, D. L., Palmucci, J. R., Schell, W., Boua, J. -V. K., . . . Perfect, J. R. (2023). Pharmacodynamics of ATI-2307 in a rabbit model of cryptococcal meningoencephalitis.. Antimicrobial agents and chemotherapy, 67(10), e0081823. doi:10.1128/aac.00818-23
Population pharmacokinetics and CSF penetration of flucytosine in adults with HIV-associated cryptococcal meningoencephalitis
Stott, K. E., Ahmadu, A., Kajanga, C., Moyo, M., Gondwe, E., Chimang'anga, W., . . . Mwandumba, H. C. (2023). Population pharmacokinetics and CSF penetration of flucytosine in adults with HIV-associated cryptococcal meningoencephalitis. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 78(4), 1015-1022. doi:10.1093/jac/dkad038
2022
Population pharmacokinetics of liposomal amphotericin B in adults with HIV-associated cryptococcal meningoencephalitis
Stott, K. E., Moyo, M., Ahmadu, A., Kajanga, C., Gondwe, E., Chimang'anga, W., . . . Martson, A. -G. (2023). Population pharmacokinetics of liposomal amphotericin B in adults with HIV-associated cryptococcal meningoencephalitis. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 78(1), 276-283. doi:10.1093/jac/dkac389
Cost-effectiveness of single, high-dose, liposomal amphotericin regimen for HIV-associated cryptococcal meningitis in five countries in sub-Saharan Africa: an economic analysis of the AMBITION-cm trial
Lawrence, D. S., Muthoga, C., Meya, D. B., Tugume, L., Williams, D., Rajasingham, R., . . . Niessen, L. W. (2022). Cost-effectiveness of single, high-dose, liposomal amphotericin regimen for HIV-associated cryptococcal meningitis in five countries in sub-Saharan Africa: an economic analysis of the AMBITION-cm trial. LANCET GLOBAL HEALTH, 10(12), E1845-E1854. doi:10.1016/S2214-109X(22)00450-8
Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis
Jarvis, J. N., Lawrence, D. S., Meya, D. B., Kagimu, E., Kasibante, J., Mpoza, E., . . . Harrison, T. S. (2022). Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis. NEW ENGLAND JOURNAL OF MEDICINE, 386(12), 1109-1120. doi:10.1056/NEJMoa2111904
2021
Cryptococcal meningoencephalitis: time for action
Stott, K. E., Loyse, A., Jarvis, J. N., Alufandika, M., Harrison, T. S., Mwandumba, H. C., . . . Hope, W. (2021). Cryptococcal meningoencephalitis: time for action. LANCET INFECTIOUS DISEASES, 21(9), E259-E271. doi:10.1016/S1473-3099(20)30771-4
Population Pharmacokinetics and Pharmacodynamics of Itraconazole for Disseminated Infection Caused by Talaromyces marneffei.
Stott, K. E., Le, T., Nguyen, T., Whalley, S., Unsworth, J., Ly, V. T., . . . Hope, W. (2021). Population Pharmacokinetics and Pharmacodynamics of Itraconazole for Disseminated Infection Caused by Talaromyces marneffei.. Antimicrobial agents and chemotherapy, 65(11), e0063621. doi:10.1128/aac.00636-21
Sensitivity of SARS-CoV-2 RNA polymerase chain reaction using a clinical and radiological reference standard: Clinical sensitivity of SARS-CoV-2 PCR.
Stockdale, A. J., Fyles, F., Farrell, C., Lewis, J., Barr, D., Haigh, K., . . . Joekes, E. (2021). Sensitivity of SARS-CoV-2 RNA polymerase chain reaction using a clinical and radiological reference standard: Clinical sensitivity of SARS-CoV-2 PCR.. The Journal of infection. doi:10.1016/j.jinf.2021.04.012
THE PHARMACOKINETICS AND PHARMACODYNAMICS OF ANTIFUNGAL AGENTS FOR HIV-ASSOCIATED INVASIVE FUNGAL INFECTIONS
Stott, K. (2021, March 30). THE PHARMACOKINETICS AND PHARMACODYNAMICS OF ANTIFUNGAL AGENTS FOR HIV-ASSOCIATED INVASIVE FUNGAL INFECTIONS.
2020
Evidence for Expanding the Role of Streptomycin in the Management of Drug-Resistant <i>Mycobacterium tuberculosis</i>
Cohen, K. A., Stott, K. E., Munsamy, V., Manson, A. L., Earl, A. M., & Pym, A. S. (2020). Evidence for Expanding the Role of Streptomycin in the Management of Drug-Resistant <i>Mycobacterium tuberculosis</i>. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 64(9). doi:10.1128/AAC.00860-20
2019
AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial (vol 19, 649, 2018)
Lawrence, D. S., Youssouf, N., Molloy, S. F., Alanio, A., Alufandika, M., Boulware, D. R., . . . Jarvis, J. N. (2019). AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial (vol 19, 649, 2018). TRIALS, 20. doi:10.1186/s13063-018-3155-9
2018
Population Pharmacokinetic Model and Meta-analysis of Outcomes of Amphotericin B Deoxycholate Use in Adults with Cryptococcal Meningitis (vol 62, e02526-17, 2018)
Stott, K. E., Beardsley, J., Whalley, S., Kibengo, F. M., Nguyen, T. H. M., Nguyen, L. N. T., . . . Day, J. (2018). Population Pharmacokinetic Model and Meta-analysis of Outcomes of Amphotericin B Deoxycholate Use in Adults with Cryptococcal Meningitis (vol 62, e02526-17, 2018). ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 62(12). doi:10.1128/AAC.02249-18
Population Pharmacokinetics and Cerebrospinal Fluid Penetration of Fluconazole in Adults with Cryptococcal Meningitis (vol 62, e00885-18, 2018)
Stott, K. E., Beardsley, J., Kolamunnage-Dona, R., Castelazo, A. S., Kibengo, F. M., Nguyen, T. H. M., . . . Hope, W. (2018). Population Pharmacokinetics and Cerebrospinal Fluid Penetration of Fluconazole in Adults with Cryptococcal Meningitis (vol 62, e00885-18, 2018). ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 62(12). doi:10.1128/AAC.02254-18
AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial
Lawrence, D. S., Youssouf, N., Molloy, S. L. F., Alanio, A., Alufandika, M., Boulware, D. R., . . . Jarvis, J. N. (2018). AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial. TRIALS, 19. doi:10.1186/s13063-018-3026-4
Pharmacokinetics of rifampicin in adult TB patients and healthy volunteers: a systematic review and meta-analysis
Stott, K. E., Pertinez, H., Sturkenboom, M. G. G., Boeree, M. J., Aarnoutse, R., Ramachandran, G., . . . Davies, G. (2018). Pharmacokinetics of rifampicin in adult TB patients and healthy volunteers: a systematic review and meta-analysis. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 73(9), 2305-2313. doi:10.1093/jac/dky152
Population Pharmacokinetics and Cerebrospinal Fluid Penetration of Fluconazole in Adults with Cryptococcal Meningitis
Stott, K. E., Beardsley, J., Kolamunnage-Dona, R., Santoyo Castelazo, A., Kibengo, F. M., Mai, N. T. H., . . . Hope, W. (2018). Population Pharmacokinetics and Cerebrospinal Fluid Penetration of Fluconazole in Adults with Cryptococcal Meningitis. Antimicrobial Agents and Chemotherapy, 62(9). doi:10.1128/aac.00885-18
Pharmacokinetics-pharmacodynamics of antifungal agents in the central nervous system
Stott, K. E., & Hope, W. (2018). Pharmacokinetics-pharmacodynamics of antifungal agents in the central nervous system. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 14(8), 803-815. doi:10.1080/17425255.2018.1492551
Population Pharmacokinetic Model and Meta-analysis of Outcomes of Amphotericin B Deoxycholate Use in Adults with Cryptococcal Meningitis
Stott, K. E., Beardsley, J., Whalley, S., Kibengo, F. M., Mai, N. T. H., Tung, N. L. N., . . . Day, J. (2018). Population Pharmacokinetic Model and Meta-analysis of Outcomes of Amphotericin B Deoxycholate Use in Adults with Cryptococcal Meningitis. Antimicrobial agents and chemotherapy, 62(7). doi:10.1128/aac.02526-17
Untapped Potential for Streptomycin: Using Genomics to Optimize Aminoglycoside Selection in Drug-Resistant Mycobacterium Tuberculosis
Cohen, K. A., Stott, K. E., Manson, A. L., Munsamy, V., Earl, A. M., & Pym, A. S. (2018). Untapped Potential for Streptomycin: Using Genomics to Optimize Aminoglycoside Selection in Drug-Resistant Mycobacterium Tuberculosis. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 197. Retrieved from https://www.webofscience.com/
2017
PHARMACOKINETICS OF ORALLY ADMINISTERED VORICONAZOLE IN AFRICAN PENGUINS (<i>SPHENISCUS DEMERSUS</i>) AFTER SINGLE AND MULTIPLE DOSES
Hyatt, M. W., Wiederhold, N. P., Hope, W. W., & Stott, K. E. (2017). PHARMACOKINETICS OF ORALLY ADMINISTERED VORICONAZOLE IN AFRICAN PENGUINS (<i>SPHENISCUS DEMERSUS</i>) AFTER SINGLE AND MULTIPLE DOSES. JOURNAL OF ZOO AND WILDLIFE MEDICINE, 48(2), 352-362. doi:10.1638/2016-0160R2.1
Therapeutic drug monitoring for invasive mould infections and disease: pharmacokinetic and pharmacodynamic considerations
Stott, K. E., & Hope, W. W. (2017). Therapeutic drug monitoring for invasive mould infections and disease: pharmacokinetic and pharmacodynamic considerations. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 72, I12-I18. doi:10.1093/jac/dkx029
2016
<i>Clostridium difficile</i>: A healthcare-associated infection of unknown significance in adults in sub-Saharan Africa
Keeley, A. J., Beeching, N. J., Stott, K. E., Roberts, P., Watson, A., & Beadsworth, M. J. (2016). <i>Clostridium difficile</i>: A healthcare-associated infection of unknown significance in adults in sub-Saharan Africa. MALAWI MEDICAL JOURNAL, 28(2), 66-69. doi:10.4314/mmj.v28i2.8
Adequacy of Rifampin Absorption after Jejunostomy Tube Administration
Stott, K. E., Singh, B., Beadsworth, M. B. J., Vaudrey, K., Khoo, S. H., & Davies, G. (2016). Adequacy of Rifampin Absorption after Jejunostomy Tube Administration. PHARMACOTHERAPY, 36(4), E23-E25. doi:10.1002/phar.1730
Brief Report: Virologic Monitoring Can Be a Cost-Effective Strategy to Diagnose Treatment Failure on First-Line ART
Vandormael, A. M., Boulware, D. R., Tanser, F. C., Baernighausen, T. W., Stott, K. E., & de Oliveira, T. (2016). Brief Report: Virologic Monitoring Can Be a Cost-Effective Strategy to Diagnose Treatment Failure on First-Line ART. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 71(4), 462-466. doi:10.1097/QAI.0000000000000870
Managing potential drug-drug interactions between gastric acid-reducing agents and antiretroviral therapy: experience from a large HIV-positive cohort
Lewis, J. M., Stott, K. E., Monnery, D., Seden, K., Beeching, N. J., Chaponda, M., . . . Beadsworth, M. B. J. (2016). Managing potential drug-drug interactions between gastric acid-reducing agents and antiretroviral therapy: experience from a large HIV-positive cohort. INTERNATIONAL JOURNAL OF STD & AIDS, 27(2), 105-109. doi:10.1177/0956462415574632
2014
Implementing antiretroviral resistance testing in a primary health care HIV treatment programme in rural KwaZulu-Natal, South Africa: early experiences, achievements and challenges
Lessells, R. J., Stott, K. E., Manasa, J., Naidu, K. K., Skingsley, A., Rossouw, T., & de Oliveira, T. (2014). Implementing antiretroviral resistance testing in a primary health care HIV treatment programme in rural KwaZulu-Natal, South Africa: early experiences, achievements and challenges. BMC HEALTH SERVICES RESEARCH, 14. doi:10.1186/1472-6963-14-116
Southern African Treatment Resistance Network (SATuRN) RegaDB HIV drug resistance and clinical management database: supporting patient management, surveillance and research in southern Africa
Manasa, J., Lessells, R., Rossouw, T., Naidu, K., Van Vuuren, C., Goedhals, D., . . . de Oliveira, T. (2014). Southern African Treatment Resistance Network (SATuRN) RegaDB HIV drug resistance and clinical management database: supporting patient management, surveillance and research in southern Africa. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION. doi:10.1093/database/bat082
2013
Combined antiretroviral and antituberculosis drug resistance following incarceration
Stott, K. E., De Oliveira, T., & Lessells, R. J. (n.d.). Combined antiretroviral and antituberculosis drug resistance following incarceration. Southern African Journal of HIV Medicine, 14(3), 135-137. doi:10.4102/sajhivmed.v14i3.67
Combined antiretroviral and anti-tuberculosis drug resistance following incarceration
Stott, K. E., de Oliviera, T., & Lessells, R. J. (2013). Combined antiretroviral and anti-tuberculosis drug resistance following incarceration. SOUTHERN AFRICAN JOURNAL OF HIV MEDICINE, 14(3), 135-137. doi:10.7196/SAJHIVMED.957
2009
Out of sight, out of mind? The psychosocial needs of children formerly associated with armed forces: a case study of Save the Children UK's work in Beni and Lubero territories, North Kivu province, Democratic Republic of Congo
Stott, K. (2009). Out of sight, out of mind? The psychosocial needs of children formerly associated with armed forces: a case study of Save the Children UK's work in Beni and Lubero territories, North Kivu province, Democratic Republic of Congo. INTERNATIONAL JOURNAL OF HEALTH PLANNING AND MANAGEMENT, 24, S52-S72. doi:10.1002/hpm.1022