Publications
2024
SARS-CoV-2 infection enhancement by Amphotericin B: Implications for disease management
A Broad-specificity Neutralizing Nanobody against Hepatitis E Virus Capsid Protein.
Wang, X., Sheng, Y., Ji, P., Deng, Y., Sun, Y., Chen, Y., . . . Zhao, Q. (2024). A Broad-specificity Neutralizing Nanobody against Hepatitis E Virus Capsid Protein.. Journal of immunology (Baltimore, Md. : 1950), 213(4), 442-455. doi:10.4049/jimmunol.2300706
Molecular surveillance of influenza A virus in Saudi Arabia: whole-genome sequencing and metagenomic approaches.
Dandachi, I., Alrezaihi, A., Amin, D., AlRagi, N., Alhatlani, B., Binjomah, A., . . . Aljabr, W. (2024). Molecular surveillance of influenza A virus in Saudi Arabia: whole-genome sequencing and metagenomic approaches.. Microbiology spectrum, 12(8), e0066524. doi:10.1128/spectrum.00665-24
SARS-CoV-2 population dynamics in immunocompetent individuals in a closed transmission chain shows genomic diversity over the course of infection.
Goldswain, H., Penrice-Randal, R., Donovan-Banfield, I., Duffy, C. W., Dong, X., Randle, N., . . . Emmett, S. R. (2024). SARS-CoV-2 population dynamics in immunocompetent individuals in a closed transmission chain shows genomic diversity over the course of infection.. Genome medicine, 16(1), 89. doi:10.1186/s13073-024-01360-1
The effect of molnupiravir and nirmatrelvir on SARS-CoV-2 genome diversity in severe models of COVID-19
The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection.
Fernández, J. J., Marín, A., Rosales, R., Penrice-Randal, R., Mlcochova, P., Alvarez, Y., . . . Fernández, N. (2024). The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection.. Biochimica et biophysica acta. Molecular basis of disease, 1870(5), 167193. doi:10.1016/j.bbadis.2024.167193
Sequential Infection with Influenza A Virus Followed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Leads to More Severe Disease and Encephalitis in a Mouse Model of COVID-19.
Clark, J. J., Penrice-Randal, R., Sharma, P., Dong, X., Pennington, S. H., Marriott, A. E., . . . Stewart, J. P. (2024). Sequential Infection with Influenza A Virus Followed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Leads to More Severe Disease and Encephalitis in a Mouse Model of COVID-19.. Viruses, 16(6), 863. doi:10.3390/v16060863
Hepatitis E virus ORF3 protein hijacking thioredoxin domain-containing protein 5 (TXNDC5) for its stability to promote viral particle release.
Sheng, Y., Deng, Y., Li, X., Ji, P., Sun, X., Liu, B., . . . Zhao, Q. (2024). Hepatitis E virus ORF3 protein hijacking thioredoxin domain-containing protein 5 (TXNDC5) for its stability to promote viral particle release.. Journal of virology, 98(4), e0164923. doi:10.1128/jvi.01649-23
A novel strategy for an anti-idiotype vaccine: nanobody mimicking neutralization epitope of porcine circovirus type 2.
Deng, Y., Sheng, Y., Zhang, G., Sun, Y., Wang, L., Ji, P., . . . Zhao, Q. (2024). A novel strategy for an anti-idiotype vaccine: nanobody mimicking neutralization epitope of porcine circovirus type 2.. Journal of virology, 98(2), e0165023. doi:10.1128/jvi.01650-23
Precision medicine for pandemics: stratification of COVID-19 molecular phenotypes defined by topological analysis of global blood gene expression
2023
Enrichment of SARS-CoV-2 sequence from nasopharyngeal swabs whilst identifying the nasal microbiome
Alrezaihi, A., Penrice-Randal, R., Dong, X., Prince, T., Randle, N., Semple, M. G., . . . Hiscox, J. A. (2023). Enrichment of SARS-CoV-2 sequence from nasopharyngeal swabs whilst identifying the nasal microbiome. Journal of Clinical Virology, 105620. doi:10.1016/j.jcv.2023.105620
SARS-CoV-2 NSP12 associates with TRiC and the P323L substitution acts as a host adaption.
Alruwaili, M., Armstrong, S., Prince, T., Erdmann, M., Matthews, D. A., Luu, L., . . . Hiscox, J. A. (2023). SARS-CoV-2 NSP12 associates with TRiC and the P323L substitution acts as a host adaption.. Journal of virology, 97(11), e0042423. doi:10.1128/jvi.00424-23
Amino acids 1811-1960 of myosin heavy chain 9 is involved in murine gammaherpesvirus 68 infection
Han, X., Clark, J. J., Sharma, P., Bentley, E. G., Kipar, A., Alsayer, M., . . . Zhao, Q. (2023). Amino acids 1811-1960 of myosin heavy chain 9 is involved in murine gammaherpesvirus 68 infection. VIROLOGY, 587. doi:10.1016/j.virol.2023.109849
Analysis of SARS-CoV-2 Population Genetics from Samples Associated with Huanan Market and Early Cases Identifies Substitutions Associated with Future Variants of Concern.
Dong, X., & Hiscox, J. A. (2023). Analysis of SARS-CoV-2 Population Genetics from Samples Associated with Huanan Market and Early Cases Identifies Substitutions Associated with Future Variants of Concern.. Viruses, 15(8), 1728. doi:10.3390/v15081728
Recombinant SARS-CoV-2 lacking initiating and internal methionine codons within ORF10 is attenuated<i>in vivo</i>
The Stereotypic Response of the Pulmonary Vasculature to Respiratory Viral Infections: Findings in Mouse Models of SARS-CoV-2, Influenza A and Gammaherpesvirus Infections
De Neck, S., Penrice-Randal, R., Clark, J. J., Sharma, P., Bentley, E. G., Kirby, A., . . . Kipar, A. (2023). The Stereotypic Response of the Pulmonary Vasculature to Respiratory Viral Infections: Findings in Mouse Models of SARS-CoV-2, Influenza A and Gammaherpesvirus Infections. Viruses, 15(8), 1637. doi:10.3390/v15081637
Enrichment of Sars-Cov-2 and Seasonal Coronavirus Sequence from Nasopharyngeal Swabs Whilst Maintaining the Background Context of the Microbiome
Alrezaihi, A., Penrice-Randal, R., Dong, X., Prince, T., Randle, N., Semple, M., . . . Hiscox, J. (2023). Enrichment of Sars-Cov-2 and Seasonal Coronavirus Sequence from Nasopharyngeal Swabs Whilst Maintaining the Background Context of the Microbiome. doi:10.2139/ssrn.4484216
Linked Mutations in the Ebola Virus Polymerase Are Associated with Organ Specific Phenotypes
Dong, X., Tree, J., Banadyga, L., He, S., Zhu, W., Tipton, T., . . . Hiscox, J. A. A. (2023). Linked Mutations in the Ebola Virus Polymerase Are Associated with Organ Specific Phenotypes. MICROBIOLOGY SPECTRUM, 11(2). doi:10.1128/spectrum.04154-22
SARS-CoV-2 NSP12 associates with the TRiC complex and the P323L substitution is a host adaption
The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.
Goldswain, H., Dong, X., Penrice-Randal, R., Alruwaili, M., Shawli, G. T., Prince, T., . . . Hiscox, J. A. (2023). The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.. Genome biology, 24(1), 47. doi:10.1186/s13059-023-02881-5
Myosin Heavy Chain 9 is Involved in Murine Gammaherpesvirus 68 Infection and as a Drug Target for Antiviral Infection
2022
Antibody response of heterologous vs homologous mRNA vaccine boosters against the SARS-CoV-2 Omicron variant: interim results from the PRIBIVAC study, A Randomized Clinical Trial
Poh, X. Y., Tan, C. W., Lee, I. R., Chavatte, J. -M., Fong, S. -W., Prince, T., . . . Young, B. E. (n.d.). Antibody response of heterologous vs homologous mRNA vaccine boosters against the SARS-CoV-2 Omicron variant: interim results from the PRIBIVAC study, A Randomized Clinical Trial. Clinical Infectious Diseases. doi:10.1093/cid/ciac345
From "crisis to recovery": A complete insight into the mechanisms of chlorine injury in the lung.
Clark, G. C., Elfsmark, L., Armstrong, S., Essex-Lopresti, A., Gustafsson, Å., Ryan, Y., . . . Jonasson, S. (2022). From "crisis to recovery": A complete insight into the mechanisms of chlorine injury in the lung.. Life sciences, 312, 121252. doi:10.1016/j.lfs.2022.121252
Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial
Donovan-Banfield, I., Penrice-Randal, R., Goldswain, H., Rzeszutek, A. M., Pilgrim, J., Bullock, K., . . . Fletcher, T. (2022). Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-34839-9
Direct RNA sequencing of respiratory syncytial virus infected human cells generates a detailed overview of RSV polycistronic mRNA and transcript abundance.
Donovan-Banfield, I., Milligan, R., Hall, S., Gao, T., Murphy, E., Li, J., . . . Matthews, D. A. (2022). Direct RNA sequencing of respiratory syncytial virus infected human cells generates a detailed overview of RSV polycistronic mRNA and transcript abundance.. PloS one, 17(11), e0276697. doi:10.1371/journal.pone.0276697
Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial
Khoo, S. H., FitzGerald, R., Saunders, G., Middleton, C., Ahmad, S., Edwards, C. J., . . . Vyas, A. (2022). Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial. The Lancet Infectious Diseases. doi:10.1016/s1473-3099(22)00644-2
Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study
Vink, E., Davis, C., MacLean, A., Pascall, D., McDonald, S. E., Gunson, R., . . . Ho, A. (2022). Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. OPEN FORUM INFECTIOUS DISEASES, 9(11). doi:10.1093/ofid/ofac531
Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.
Siggins, M. K., Davies, K., Fellows, R., Thwaites, R. S., Baillie, J. K., Semple, M. G., . . . ISARIC4C Investigators. (2022). Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.. Immunology. doi:10.1111/imm.13585
Blood gene expression predicts intensive care unit admission in hospitalised patients with COVID-19.
Penrice-Randal, R., Dong, X., Shapanis, A. G., Gardner, A., Harding, N., Legebeke, J., . . . Baralle, D. (2022). Blood gene expression predicts intensive care unit admission in hospitalised patients with COVID-19.. Frontiers in immunology, 13, 988685. doi:10.3389/fimmu.2022.988685
Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number
Keeling, M. J., Dyson, L., Guyver-Fletcher, G., Holmes, A., Semple, M. G., Tildesley, M. J., & Hill, E. M. (2022). Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number. STATISTICAL METHODS IN MEDICAL RESEARCH, 31(9), 1716-1737. doi:10.1177/09622802211070257
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection.
Kemp, S. A., Collier, D. A., Datir, R. P., Ferreira, I. A. T. M., Gayed, S., Jahun, A., . . . Gupta, R. K. (2022). Author Correction: SARS-CoV-2 evolution during treatment of chronic infection.. Nature, 608(7922), E23. doi:10.1038/s41586-022-05104-2
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies.
Collier, D. A., De Marco, A., Ferreira, I. A. T. M., Meng, B., Datir, R. P., Walls, A. C., . . . Gupta, R. K. (2022). Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies.. Nature, 608(7922), E24. doi:10.1038/s41586-022-05103-3
A Randomised -Controlled Phase 2 trial of Molnupiravir in Unvaccinated and Vaccinated Individuals with Early SARS-CoV-2
Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19
Norris, T., Razieh, C., Zaccardi, F., Yates, T., Islam, N., Gillies, C. L., . . . Khunti, K. (2022). Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19. HEART, 108(15), 1200-1208. doi:10.1136/heartjnl-2021-320047
RIPpore: A Novel Host-Derived Method for the Identification of Ricin Intoxication through Oxford Nanopore Direct RNA Sequencing
Ryan, Y., Harrison, A., Trivett, H., Hartley, C., David, J., Clark, G. C., & Hiscox, J. A. (2022). RIPpore: A Novel Host-Derived Method for the Identification of Ricin Intoxication through Oxford Nanopore Direct RNA Sequencing. TOXINS, 14(7). doi:10.3390/toxins14070470
Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages
Prince, T., Dong, X., Penrice-Randal, R., Randle, N., Hartley, C., Goldswain, H., . . . Hiscox, J. A. (2022). Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages. MSPHERE, 7(3). doi:10.1128/msphere.00913-21
SARS-CoV-2 minor variant genomes at the start of the pandemic contained markers of VoCs
Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers
Dong, X., Penrice-Randal, R., Goldswain, H., Prince, T., Randle, N., Donovan-Banfield, I., . . . Hiscox, J. A. (2022). Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers. GIGASCIENCE, 11. doi:10.1093/gigascience/giac045
Evaluating the Immune Response in Treatment-Naive Hospitalised Patients With Influenza and COVID-19
Legebeke, J., Lord, J., Penrice-Randal, R., Vallejo, A. F., Poole, S., Brendish, N. J., . . . Baralle, D. (2022). Evaluating the Immune Response in Treatment-Naive Hospitalised Patients With Influenza and COVID-19. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.853265
Neuroinvasion and Neurotropism by SARS-CoV-2 Variants in the K18-hACE2 Mouse
Seehusen, F., Clark, J. J., Sharma, P., Bentley, E. G., Kirby, A., Subramaniam, K., . . . Kipar, A. (2022). Neuroinvasion and Neurotropism by SARS-CoV-2 Variants in the K18-hACE2 Mouse. VIRUSES-BASEL, 14(5). doi:10.3390/v14051020
Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission
Relph, K. A., Russell, C. D., Fairfield, C. J., Turtle, L., de Silva, T. I., Siggins, M. K., . . . Young, P. (2022). Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission. Open Forum Infectious Diseases, 9(5). doi:10.1093/ofid/ofac179
Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study
Millar, J. E., Neyton, L., Seth, S., Dunning, J., Merson, L., Murthy, S., . . . Baillie, J. K. (2022). Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-08032-3
SARS-CoV-2 Testing in the Community: Testing Positive Samples with the TaqMan SARS-CoV-2 Mutation Panel To Find Variants in Real Time.
Ashford, F., Best, A., Dunn, S. J., Ahmed, Z., Siddiqui, H., Melville, J., . . . McNally, A. (2022). SARS-CoV-2 Testing in the Community: Testing Positive Samples with the TaqMan SARS-CoV-2 Mutation Panel To Find Variants in Real Time.. Journal of clinical microbiology, 60(4), e0240821. doi:10.1128/jcm.02408-21
Complement-Mediated Neutralisation Identified in Ebola Virus Disease Survivor Plasma: Implications for Protection and Pathogenesis
Mellors, J., Tipton, T., Fehling, S. K., Akoi Bore, J., Koundouno, F. R., Hall, Y., . . . Carroll, M. (n.d.). Complement-Mediated Neutralisation Identified in Ebola Virus Disease Survivor Plasma: Implications for Protection and Pathogenesis. Frontiers in Immunology, 13. doi:10.3389/fimmu.2022.857481
Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study
Narhi, F., Moonesinghe, S. R., Shenkin, S. D., Drake, T. M., Mulholland, R. H., Donegan, C., . . . Docherty, A. B. (2022). Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. LANCET DIGITAL HEALTH, 4(4). Retrieved from https://www.webofscience.com/
Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission
Aggarwal, D., Page, A. J., Schaefer, U., Savva, G. M., Myers, R., Volz, E., . . . Harrison, E. M. (2022). Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-28371-z
Antibody Response of Heterologous vs Homologous mRNA Vaccine Boosters Against the SARS-CoV-2 Omicron Variant: Interim Results from the PRIBIVAC Study, A Randomized Clinical Trial
Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.
Zhang, B., Fan, M., Fan, J., Luo, Y., Wang, J., Wang, Y., . . . Zhou, E. -M. (2022). Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.. Microbiology spectrum, 10(1), e0226521. doi:10.1128/spectrum.02265-21
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission
Aggarwal, D., Warne, B., Jahun, A. S., Hamilton, W. L., Fieldman, T., du Plessis, L., . . . Consor, C. G. U. K. C. O. G. -U. K. (2022). Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-021-27942-w
Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway
Zhou, J., Peacock, T. P., Brown, J. C., Goldhill, D. H., Elrefaey, A. M. E., Penrice-Randal, R., . . . Barclay, W. S. (2022). Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway. Cell Reports, 110344. doi:10.1016/j.celrep.2022.110344
Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway.
Zhou, J., Peacock, T., Brown, J., Goldhill, D., Elrefaey, A., Penrice-Randal, R., . . . Barclay, W. (2021). Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway.. doi:10.21203/rs.3.rs-829214/v1
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (2022). SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. Cell, 185(3), 467-484.e15. doi:10.1016/j.cell.2021.12.046
Tissue Proteomic Analysis Identifies Mechanisms and Stages of Immunopathology in Fatal COVID-19
Russell, C. D., Valanciute, A., Gachanja, N. N., Stephen, J., Penrice-Randal, R., Armstrong, S. D., . . . Lucas, C. D. (2022). Tissue Proteomic Analysis Identifies Mechanisms and Stages of Immunopathology in Fatal COVID-19. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 66(2), 196-205. doi:10.1165/rcmb.2021-0358OC
Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study
Sullivan, M. K., Lees, J. S., Drake, T. M., Docherty, A. B., Oates, G., Hardwick, H. E., . . . Mark, P. B. (2022). Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study. NEPHROLOGY DIALYSIS TRANSPLANTATION, 37(2), 271-284. doi:10.1093/ndt/gfab303
Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol
Knight, S. R., Gupta, R. K., Ho, A., Pius, R., Buchan, I., Carson, G., . . . Harrison, E. M. (2022). Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. THORAX, 77(6), 606-615. doi:10.1136/thoraxjnl-2021-217629
2021
Direct RNA sequencing of Respiratory Syncytial Virus infected human cells generates a detailed overview of RSV polycistronic mRNA and transcript abundance
Mapping the human genetic architecture of COVID-19
Niemi, M. E. K., Karjalainen, J., Daly, M., Ganna, A., Mehtonen, J., Cordioli, M., . . . Dopazo, X. (2021). Mapping the human genetic architecture of COVID-19. NATURE, 600(7889), 472-+. doi:10.1038/s41586-021-03767-x
Antiviral activity of Molnupiravir precursor NHC against SARS-CoV-2 Variants of Concern (VOCs) and implications for the therapeutic window and resistance
Dose-Dependent Response to Infection with Ebola Virus in the Ferret Model and Evidence of Viral Evolution in the Eye
Watson, R. J., Tree, J., Fotheringham, S. A., Hall, Y., Dong, X., Steeds, K., . . . Funnell, S. G. P. (2021). Dose-Dependent Response to Infection with Ebola Virus in the Ferret Model and Evidence of Viral Evolution in the Eye. JOURNAL OF VIROLOGY, 95(24). doi:10.1128/JVI.00833-21
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells
de, S. T. I., Liu, G., Lindsey, B. B., Dong, D., Moore, S. C., Hsu, N. S., . . . Dong, T. (2021). The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. ISCIENCE, 24(11). doi:10.1016/j.isci.2021.103353
Cell Division Control Protein 42 Interacts With Hepatitis E Virus Capsid Protein and Participates in Hepatitis E Virus Infection
Fan, M., Luo, Y., Zhang, B., Wang, J., Chen, T., Liu, B., . . . Zhou, E. -M. (2021). Cell Division Control Protein 42 Interacts With Hepatitis E Virus Capsid Protein and Participates in Hepatitis E Virus Infection. FRONTIERS IN MICROBIOLOGY, 12. doi:10.3389/fmicb.2021.775083
A prenylated dsRNA sensor protects against severe COVID-19
Wickenhagen, A., Sugrue, E., Lytras, S., Kuchi, S., Noerenberg, M., Turnbull, M. L., . . . Wilson, S. J. (2021). A prenylated dsRNA sensor protects against severe COVID-19. SCIENCE, 374(6567). doi:10.1126/science.abj3624
Resistance of SARS-CoV-2 variants to neutralization by convalescent plasma from early COVID-19 outbreak in Singapore
Wang, B., Goh, Y. S., Prince, T., Ngoh, E. Z. X., Salleh, S. N. M., Hor, P. X., . . . Wang, C. -I. (2021). Resistance of SARS-CoV-2 variants to neutralization by convalescent plasma from early COVID-19 outbreak in Singapore. NPJ VACCINES, 6(1). doi:10.1038/s41541-021-00389-2
Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study
Hurst, E. A., Mellanby, R. J., Handel, I., Griffith, D. M., Rossi, A. G., Walsh, T. S., . . . Russell, C. D. (2021). Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study. BMJ OPEN, 11(10). doi:10.1136/bmjopen-2021-055435
A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19
Huo, J., Mikolajek, H., Le Bas, A., Clark, J. J., Sharma, P., Kipar, A., . . . Moynie, L. (2021). A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-25480-z
Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice
Salzer, R., Clark, J. J., Vaysburd, M., Chang, V. T., Albecka, A., Kiss, L., . . . Lowe, J. (2021). Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice. FEBS LETTERS, 595(18), 2323-2340. doi:10.1002/1873-3468.14171
Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study.
Twohig, K. A., Nyberg, T., Zaidi, A., Thelwall, S., Sinnathamby, M. A., Aliabadi, S., . . . COVID-19 Genomics UK (COG-UK) consortium. (2021). Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study.. The Lancet. Infectious diseases, 22(1), 35-42. doi:10.1016/s1473-3099(21)00475-8
Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic
Jackson, B., Boni, M. F., Bull, M. J., Colleran, A., Colquhoun, R. M., Darby, A. C., . . . Rambaut, A. (2021). Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic. Cell. doi:10.1016/j.cell.2021.08.014
Using Oxford Nanopore Technology direct RNA sequencing to identify depurination events induced by ricin and other ribosome inactivating proteins
Shutting the gate before the horse has bolted: is it time for a conversation about SARS-CoV-2 and antiviral drug resistance?
Hiscox, J. A., Khoo, S. H., Stewart, J. P., & Owen, A. (2021). Shutting the gate before the horse has bolted: is it time for a conversation about SARS-CoV-2 and antiviral drug resistance?. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 76(9), 2230-2233. doi:10.1093/jac/dkab189
A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19
Amplicon and Metagenomic Analysis of Middle East Respiratory Syndrome (MERS) Coronavirus and the Microbiome in Patients with Severe MERS.
Aljabr, W., Alruwaili, M., Penrice-Randal, R., Alrezaihi, A., Harrison, A. J., Ryan, Y., . . . Hiscox, J. A. (2021). Amplicon and Metagenomic Analysis of Middle East Respiratory Syndrome (MERS) Coronavirus and the Microbiome in Patients with Severe MERS.. mSphere, e0021921. doi:10.1128/msphere.00219-21
Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study
Drake, T. M., Riad, A. M., Fairfield, C. J., Egan, C., Knight, S. R., Pius, R., . . . Semple, M. G. (2021). Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. LANCET, 398(10296), 223-237. Retrieved from https://www.webofscience.com/
Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort
Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., . . . Khunti, K. (2021). Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort. OBESITY, 29(7), 1223-1230. doi:10.1002/oby.23178
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7
Meng, B., Kemp, S. A., Papa, G., Datir, R., Ferreira, I. A. T. M., Marelli, S., . . . Gupta, R. K. (2021). Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7. CELL REPORTS, 35(13). doi:10.1016/j.celrep.2021.109292
Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice
Salzer, R., Clark, J., Vaysburd, M., Chang, V., Albecka, A., Kiss, L., . . . Löwe, J. (2021). Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice. doi:10.1101/2021.05.18.444622
Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England
Volz, E., Mishra, S., Chand, M., Barrett, J. C., Johnson, R., Geidelberg, L., . . . Ferguson, N. M. (2021). Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England. NATURE, 593(7858), 266-+. doi:10.1038/s41586-021-03470-x
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies
Collier, D. A., De Marco, A., Ferreira, I. A. T. M., Meng, B., Datir, R. P., Walls, A. C., . . . Gupta, R. K. (2021). Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies. NATURE, 593(7857), 136-+. doi:10.1038/s41586-021-03412-7
Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study
Graham, M. S., Sudre, C. H., May, A., Antonelli, M., Murray, B., Varsaysky, T., . . . Ourselin, S. (2021). Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study. LANCET PUBLIC HEALTH, 6(5), E335-E345. doi:10.1016/S2468-2667(21)00055-4
SARS-CoV-2 one year on: evidence for ongoing viral adaptation
Peacock, T. P., Penrice-Randal, R., Hiscox, J. A., & Barclay, W. S. (2021). SARS-CoV-2 one year on: evidence for ongoing viral adaptation. JOURNAL OF GENERAL VIROLOGY, 102(4). doi:10.1099/jgv.0.001584
Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study
Gupta, R. K., Harrison, E. M., Ho, A., Docherty, A. B., Knight, S. R., van Smeden, M., . . . Noursadeghi, M. (2021). Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(4), 349-359. doi:10.1016/S2213-2600(20)30559-2
Longitudinal antibody and T cell responses in Ebola virus disease survivors and contacts: an observational cohort study.
Thom, R., Tipton, T., Strecker, T., Hall, Y., Akoi Bore, J., Maes, P., . . . Carroll, M. W. (2021). Longitudinal antibody and T cell responses in Ebola virus disease survivors and contacts: an observational cohort study.. The Lancet. Infectious diseases, 21(4), 507-516. doi:10.1016/s1473-3099(20)30736-2
Covid-19: variants and vaccination
Darby, A. C., & Hiscox, J. A. (2021). Covid-19: variants and vaccination. BMJ-BRITISH MEDICAL JOURNAL, 372. doi:10.1136/bmj.n771
Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.
Thwaites, R. S., Sanchez Sevilla Uruchurtu, A., Siggins, M. K., Liew, F., Russell, C. D., Moore, S. C., . . . ISARIC4C investigators. (2021). Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.. Science Immunology, 6(57). doi:10.1126/sciimmunol.abg9873
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity
Thomson, E. C., Rosen, L. E., Shepherd, J. G., Spreafico, R., Filipe, A. D. S., Wojcechowskyj, J. A., . . . Snell, G. (2021). Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. CELL, 184(5), 1171-+. doi:10.1016/j.cell.2021.01.037
Genetic mechanisms of critical illness in COVID-19
Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A. D., Rawlik, K., Pasko, D., . . . Baillie, J. K. (2021). Genetic mechanisms of critical illness in COVID-19. NATURE, 591(7848), 92-+. doi:10.1038/s41586-020-03065-y
Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans
Dong, X., Penrice-Randal, R., Goldswain, H., Prince, T., Randle, N., Salguero, J., . . . Hiscox, J. (2021). Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans. doi:10.1101/2021.03.03.433753
Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19
Salguero, F. J., White, A. D., Slack, G. S., Fotheringham, S. A., Bewley, K. R., Gooch, K. E., . . . Carroll, M. W. (2021). Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-21389-9
Tissue-Specific Immunopathology in Fatal COVID-19
Dorward, D. A., Russell, C. D., Um, I. H., Elshani, M., Armstrong, S. D., Penrice-Randal, R., . . . Lucas, C. D. (2021). Tissue-Specific Immunopathology in Fatal COVID-19. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 203(2), 192-201. doi:10.1164/rccm.202008-3265OC
Analysis of an Ebola virus disease survivor whose host and viral markers were predictive of death indicates the effectiveness of medical countermeasures and supportive care
Bosworth, A., Rickett, N. Y., Dong, X., Ng, L. F. P., Garcia-Dorival, I., Matthews, D. A., . . . Hiscox, J. A. (2021). Analysis of an Ebola virus disease survivor whose host and viral markers were predictive of death indicates the effectiveness of medical countermeasures and supportive care. GENOME MEDICINE, 13(1). doi:10.1186/s13073-020-00811-9
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
Volz, E., Hill, V., McCrone, J. T., Price, A., Jorgensen, D., O'Toole, Á., . . . Connor, T. R. (2021). Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.. Cell, 184(1), 64-75.e11. doi:10.1016/j.cell.2020.11.020
Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity
Ryan, K. A., Bewley, K. R., Fotheringham, S. A., Slack, G. S., Brown, P., Hall, Y., . . . Carroll, M. W. (2021). Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-020-20439-y
2020
Amplicon and metagenomic analysis of MERS-CoV and the microbiome in patients with severe Middle East respiratory syndrome (MERS)
Aljabr, W., Alruwaili, M., Penrice-Randal, R., Alrezaihi, A., Harrison, A. J., Ryan, Y., . . . Hiscox, J. (2020). Amplicon and metagenomic analysis of MERS-CoV and the microbiome in patients with severe Middle East respiratory syndrome (MERS). doi:10.1101/2020.11.28.400671
Neuropilin-1 is a host factor for SARS-CoV-2 infection
Daly, J. L., Simonetti, B., Klein, K., Chen, K. -E., Williamson, M. K., Anton-Plagaro, C., . . . Yamauchi, Y. (2020). Neuropilin-1 is a host factor for SARS-CoV-2 infection. SCIENCE, 370(6518), 861-+. doi:10.1126/science.abd3072
Structural Characterization of Non-structural Protein 9 Complexed With Specific Nanobody Pinpoints Two Important Residues Involved in Porcine Reproductive and Respiratory Syndrome Virus Replication
Wang, Y., Li, R., Qiao, S., Wang, J., Liu, H., Li, Z., . . . Zhou, E. -M. (2020). Structural Characterization of Non-structural Protein 9 Complexed With Specific Nanobody Pinpoints Two Important Residues Involved in Porcine Reproductive and Respiratory Syndrome Virus Replication. FRONTIERS IN MICROBIOLOGY, 11. doi:10.3389/fmicb.2020.581856
Quantification of Ebola virus replication kinetics in vitro
Liao, L. E., Carruthers, J., Smither, S. J., Weller, S. A., Williamson, D., Laws, T. R., . . . Molina-Paris, C. (2020). Quantification of Ebola virus replication kinetics in vitro. PLOS COMPUTATIONAL BIOLOGY, 16(11). doi:10.1371/journal.pcbi.1008375
Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020
Thompson, C. P., Grayson, N. E., Paton, R. S., Bolton, J. S., Lourenco, J., Penman, B. S., . . . Simmonds, P. (2020). Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. EUROSURVEILLANCE, 25(42), 33-41. doi:10.2807/1560-7917.ES.2020.25.42.2000685
Quantification of Ebola virus replication kinetics in vitro
Sequential infection with influenza A virus followed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to more severe disease and encephalitis in a mouse model of COVID-19
Clark, J., Penrice-Randal, R., Sharma, P., Kipar, A., Dong, X., Pennington, S., . . . Stewart, J. (2020). Sequential infection with influenza A virus followed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to more severe disease and encephalitis in a mouse model of COVID-19. doi:10.1101/2020.10.13.334532
Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism
Moore, S. C., Penrice-Randal, R., Alruwaili, M., Randle, N., Armstrong, S., Hartley, C., . . . Hiscox, J. A. (2020). Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism. VIRUSES-BASEL, 12(10). doi:10.3390/v12101164
Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.
Drake, T. M., Docherty, A. B., Harrison, E. M., Quint, J. K., Adamali, H., Agnew, S., . . . ISARIC4C Investigators. (2020). Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.. Am J Respir Crit Care Med. doi:10.1164/rccm.202007-2794OC
Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.
Knight, S. R., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T. M., . . . ISARIC4C investigators. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.. BMJ: British Medical Journal, 370. doi:10.1136/bmj.m3339
Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease
Dong, X., Munoz-Basagoiti, J., Rickett, N. Y., Pollakis, G., Paxton, W. A., Guenther, S., . . . Hiscox, J. A. (2020). Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease. GENOME BIOLOGY, 21(1). doi:10.1186/s13059-020-02148-3
Pseudotyping of VSV with Ebola virus glycoprotein is superior to HIV-1 for the assessment of neutralising antibodies
Steeds, K., Hall, Y., Slack, G. S., Longet, S., Strecker, T., Fehling, S. K., . . . Carroll, M. W. (2020). Pseudotyping of VSV with Ebola virus glycoprotein is superior to HIV-1 for the assessment of neutralising antibodies. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-71225-1
Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study
Swann, O., Holden, K., Turtle, L., Pollock, L., Fairfield, C., Drake, T., . . . ISARIC Coronavirus Clinical Characterisation Consortium (ISARIC4C) Investigators. (2020). Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study. BMJ, 370. doi:10.1136/bmj.m3249
A Comparison of Whole Genome Sequencing of SARS-CoV-2 Using Amplicon-Based Sequencing, Random Hexamers, and Bait Capture
Nasir, J. A., Kozak, R. A., Aftanas, P., Raphenya, A. R., Smith, K. M., Maguire, F., . . . Mubareka, S. (2020). A Comparison of Whole Genome Sequencing of SARS-CoV-2 Using Amplicon-Based Sequencing, Random Hexamers, and Bait Capture. Viruses, 12(8). doi:10.3390/v12080895
Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein
Davidson, A. D., Williamson, M. K., Lewis, S., Shoemark, D., Carroll, M. W., Heesom, K. J., . . . Matthews, D. A. (2020). Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein. Genome Medicine: medicine in the post-genomic era, 12. doi:10.1186/s13073-020-00763-0
Tissue-specific tolerance in fatal Covid-19
Dorward, D., Russell, C., Um, I. H., Elshani, M., Armstrong, S., Penrice-Randal, R., . . . Lucas, C. (2020). Tissue-specific tolerance in fatal Covid-19. doi:10.1101/2020.07.02.20145003
Deep splicing plasticity of the human adenovirus type 5 transcriptome as a driver of virus evolution
Donovan-Banfield, I., Turnell, A., Hiscox, J., Leppard, K., & Matthews, D. (2020). Deep splicing plasticity of the human adenovirus type 5 transcriptome as a driver of virus evolution. Access Microbiology, 2(7A). doi:10.1099/acmi.ac2020.po0028
Neuropilin-1 is a host factor for SARS-CoV-2 infection
An integrated national scale SARS-CoV-2 genomic surveillance network
Darby, A. (2020). An integrated national scale SARS-CoV-2 genomic surveillance network. The Lancet Microbe. doi:10.1016/s2666-5247(20)30054-9
Dose-dependent response to infection with SARS-CoV-2 in the ferret model: evidence of protection to re-challenge
The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins
Touzelet, O., Broadbent, L., Armstrong, S. D., Aljabr, W., Cloutman-Green, E., Power, U. F., & Hiscox, J. A. (2020). The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins. MOLECULAR & CELLULAR PROTEOMICS, 19(5), 793-807. doi:10.1074/mcp.RA119.001546
The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins.
Touzelet, O., Broadbent, L., Armstrong, S. D., Aljabr, W., Cloutman-Green, E., Power, U. F., & Hiscox, J. A. (2020). The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins.. Molecular & cellular proteomics : MCP, 19(5), 793-807. doi:10.1074/mcp.ra119.001546
An Investigation of the Effect of Transfected Defective, Ebola Virus Genomes on Ebola Replication
Smither, S. J., Garcia-Dorival, I., Eastaugh, L., Findlay, J. S., O'Brien, L. M., Carruthers, J., . . . Laws, T. R. (2020). An Investigation of the Effect of Transfected Defective, Ebola Virus Genomes on Ebola Replication. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 10. doi:10.3389/fcimb.2020.00159
UTILISATION OF 'OMIC APPROACHES TO IMPROVE THE IDENTIFICATION, DIAGNOSIS AND TREATMENT OF EXPOSURE TO THE PLANT TOXIN RICIN
Clark, G. C., Armstrong, S., Harrison, A., Moore, K., Essex-Lopresti, A., David, J., . . . Hiscox, J. (2020). UTILISATION OF 'OMIC APPROACHES TO IMPROVE THE IDENTIFICATION, DIAGNOSIS AND TREATMENT OF EXPOSURE TO THE PLANT TOXIN RICIN. TOXICON, 177, S31. Retrieved from https://www.webofscience.com/
Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage site
Deep splicing plasticity of the human adenovirus type 5 transcriptome drives virus evolution
Donovan-Banfield, I., Turnell, A. S., Hiscox, J. A., Leppard, K. N., & Matthews, D. A. (2020). Deep splicing plasticity of the human adenovirus type 5 transcriptome drives virus evolution. COMMUNICATIONS BIOLOGY, 3(1). doi:10.1038/s42003-020-0849-9
Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19
Moore, S., Penrice-Randal, R., Alruwaili, M., Dong, X., Pullan, S., Carter, D., . . . Hiscox, J. (2020). Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19. doi:10.1101/2020.03.05.20032011
TREM-1 activation is a potential key regulator in driving severe pathogenesis of enterovirus A71 infection
Amrun, S. N., Tan, J. J. L., Rickett, N. Y., Cox, J. A., Lee, B., Griffiths, M. J., . . . Ng, L. F. P. (2020). TREM-1 activation is a potential key regulator in driving severe pathogenesis of enterovirus A71 infection. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-60761-5
Coronaviruses in animals and humans
Ng, L. F. P., & Hiscox, J. A. (2020). Coronaviruses in animals and humans. BMJ-BRITISH MEDICAL JOURNAL, 368. doi:10.1136/bmj.m634
2019
Investigating the Cellular Transcriptomic Response Induced by the Makona Variant of Ebola Virus in Differentiated THP-1 Cells
Bosworth, A., Dowall, S. D., Armstrong, S., Liu, X., Dong, X., Bruce, C. B., . . . Hiscox, J. A. (2019). Investigating the Cellular Transcriptomic Response Induced by the Makona Variant of Ebola Virus in Differentiated THP-1 Cells. VIRUSES-BASEL, 11(11). doi:10.3390/v11111023
High Resolution Analysis of Respiratory Syncytial Virus Infection In Vivo
Aljabr, W., Armstrong, S., Rickett, N. Y., Pollakis, G., Touzelet, O., Cloutman-Green, E., . . . Hiscox, J. A. (2019). High Resolution Analysis of Respiratory Syncytial Virus Infection In Vivo. VIRUSES-BASEL, 11(10). doi:10.3390/v11100926
Direct Interaction Between CD163 N-Terminal Domain and MYH9 C-Terminal Domain Contributes to Porcine Reproductive and Respiratory Syndrome Virus Internalization by Permissive Cells
Hou, G., Xue, B., Li, L., Nan, Y., Zhang, L., Li, K., . . . Zhou, E. -M. (2019). Direct Interaction Between CD163 N-Terminal Domain and MYH9 C-Terminal Domain Contributes to Porcine Reproductive and Respiratory Syndrome Virus Internalization by Permissive Cells. FRONTIERS IN MICROBIOLOGY, 10. doi:10.3389/fmicb.2019.01815
Trimester-specific Zika virus infection affects placental responses in women
TREM-1 activation is a key regulator in driving severe pathogenesis of enterovirus 71 infection
Amrun, S. N., Tan, J. J. L., Rickett, N. Y., Cox, J. A., Lee, B., Griffiths, M. J., . . . Ng, L. F. P. (2019). TREM-1 activation is a key regulator in driving severe pathogenesis of enterovirus 71 infection. doi:10.1101/682914
Chicken Organic Anion-Transporting Polypeptide 1A2, a Novel Avian Hepatitis E Virus (HEV) ORF2-Interacting Protein, Is Involved in Avian HEV Infection
Li, H., Fan, M., Liu, B., Ji, P., Chen, Y., Zhang, B., . . . Zhou, E. -M. (2019). Chicken Organic Anion-Transporting Polypeptide 1A2, a Novel Avian Hepatitis E Virus (HEV) ORF2-Interacting Protein, Is Involved in Avian HEV Infection. JOURNAL OF VIROLOGY, 93(11). doi:10.1128/JVI.02205-18
Quantitative Proteomics Analysis Revealed Compromised Chicken Dendritic Cells Function at Early Stage of Very Virulent Infectious Bursal Disease Virus Infection.
Yasmin, A. R., Omar, A. R., Farhanah, M. I., Hiscox, A. J., & Yeap, S. K. (2019). Quantitative Proteomics Analysis Revealed Compromised Chicken Dendritic Cells Function at Early Stage of Very Virulent Infectious Bursal Disease Virus Infection.. Avian diseases, 63(2), 275-288. doi:10.1637/11936-072418-reg.1
High throughput screening to identify host-factors involved in RSV fusion
Kelly, J., Logan, L., Hiscox, J., Armstrong, S., Wilson, S., & Bailey, D. (2019). High throughput screening to identify host-factors involved in RSV fusion. Access Microbiology, 1(1A). doi:10.1099/acmi.ac2019.po0402
The secretome profiling of a pediatric airway epithelium infected with human respiratory syncytial virus (hRSV) identified aberrant apical/basolateral trafficking and novel immune modulating (CXCL6, CXCL16, CSF3) and antiviral (CEACAM1) proteins
Touzelet, O., Broadbent, L., Armstrong, S., Aljabr, W., Cloutman-Green, E., Power, U., & Hiscox, J. (2019). The secretome profiling of a pediatric airway epithelium infected with human respiratory syncytial virus (hRSV) identified aberrant apical/basolateral trafficking and novel immune modulating (CXCL6, CXCL16, CSF3) and antiviral (CEACAM1) proteins. Access Microbiology, 1(1A). doi:10.1099/acmi.ac2019.po0458
Experimental infection of rabbit with swine-derived hepatitis E virus genotype 4
Liu, B., Chen, Y., Sun, Y., Nan, Y., Li, H., Du, T., . . . Zhou, E. -M. (2019). Experimental infection of rabbit with swine-derived hepatitis E virus genotype 4. VETERINARY MICROBIOLOGY, 229, 168-175. doi:10.1016/j.vetmic.2019.01.001
UNBIASED WHOLE GENOME SEQUENCE ANALYSIS OF THE MURINE TRANSCRIPTOME IN RESPONSE TO RICIN EXPOSURE VIA THE PULMONARY ROUTE
Essex-Lopresti, A., David, J., Moore, K., Armstrong, S., Auton, P., Rutter, S., . . . Clark, G. C. (2019). UNBIASED WHOLE GENOME SEQUENCE ANALYSIS OF THE MURINE TRANSCRIPTOME IN RESPONSE TO RICIN EXPOSURE VIA THE PULMONARY ROUTE. In TOXICON Vol. 158 (pp. S6). doi:10.1016/j.toxicon.2018.10.029
Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak
Kafetzopoulou, L. E., Pullan, S. T., Lemey, P., Suchard, M. A., Ehichioya, D. U., Pahlmann, M., . . . Duraffour, S. (2019). Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak. Science, 363(6422), 74-77. doi:10.1126/science.aau9343
Immunological observations and transcriptomic analysis of trimester-specific full-term placentas from three Zika virus-infected women
Lum, F. -M., Narang, V., Hue, S., Chen, J., McGovern, N., Rajarethinam, R., . . . Ng, L. F. P. (n.d.). Immunological observations and transcriptomic analysis of trimester-specific full-term placentas from three Zika virus-infected women. Clinical and Translational Immunology, 8(11). doi:10.1002/cti2.1082
2018
Assessment of metagenomic Nanopore and Illumina sequencing for recovering whole genome sequences of chikungunya and dengue viruses directly from clinical samples
Kafetzopoulou, L. E., Efthymiadis, K., Lewandowski, K., Crook, A., Carter, D., Osborne, J., . . . Pullan, S. T. (2018). Assessment of metagenomic Nanopore and Illumina sequencing for recovering whole genome sequences of chikungunya and dengue viruses directly from clinical samples. EUROSURVEILLANCE, 23(50), 18-30. doi:10.2807/1560-7917.ES.2018.23.50.1800228
T-Cell Receptor Diversity and the Control of T-Cell Homeostasis Mark Ebola Virus Disease Survival in Humans
Speranza, E., Ruibal, P., Port, J. R., Feng, F., Burkhardt, L., Grundhoff, A., . . . Munoz-Fontela, C. (2018). T-Cell Receptor Diversity and the Control of T-Cell Homeostasis Mark Ebola Virus Disease Survival in Humans. JOURNAL OF INFECTIOUS DISEASES, 218, S508-S518. doi:10.1093/infdis/jiy352
Porcine reproductive and respiratory syndrome virus inhibits MARC-145 proliferation via inducing apoptosis and G2/M arrest by activation of Chk/Cdc25C and p53/p21 pathway
Song, L., Han, X., Jia, C., Zhang, X., Jiao, Y., Du, T., . . . Mu, Y. (2018). Porcine reproductive and respiratory syndrome virus inhibits MARC-145 proliferation via inducing apoptosis and G2/M arrest by activation of Chk/Cdc25C and p53/p21 pathway. VIROLOGY JOURNAL, 15. doi:10.1186/s12985-018-1081-9
Cross-species infection of mice by rabbit hepatitis E virus
Sun, Y., Lu, Q., Liu, B., Sheng, Y., Du, T., Hiscox, J. A., . . . Zhao, Q. (2018). Cross-species infection of mice by rabbit hepatitis E virus. VETERINARY MICROBIOLOGY, 225, 48-52. doi:10.1016/j.vetmic.2018.09.015
Viperin Poisons Viral Replication
Ng, L. F. P., & Hiscox, J. A. (2018). Viperin Poisons Viral Replication. CELL HOST & MICROBE, 24(2), 181-183. doi:10.1016/j.chom.2018.07.014
Recombinant MYH9 protein C-terminal domain blocks porcine reproductive and respiratory syndrome virus internalization by direct interaction with viral glycoprotein 5
Li, L., Xue, B., Sun, W., Gu, G., Hou, G., Zhang, L., . . . Zhou, E. -M. (2018). Recombinant MYH9 protein C-terminal domain blocks porcine reproductive and respiratory syndrome virus internalization by direct interaction with viral glycoprotein 5. ANTIVIRAL RESEARCH, 156, 10-20. doi:10.1016/j.antiviral.2018.06.001
Characterization of Three Novel Linear Neutralizing B-Cell Epitopes in the Capsid Protein of Swine Hepatitis E Virus
Chen, Y., Liu, B., Sun, Y., Li, H., Du, T., Nan, Y., . . . Zhao, Q. (n.d.). Characterization of Three Novel Linear Neutralizing B-Cell Epitopes in the Capsid Protein of Swine Hepatitis E Virus. Journal of Virology, 92. doi:10.1128/JVI.00251-18
Assessment of Metagenomic MinION and Illumina sequencing as an approach for the recovery of whole genome sequences of chikungunya and dengue viruses directly from clinical samples
Zika Virus Infection Preferentially Counterbalances Human Peripheral Monocyte and/or NK Cell Activity
Lum, F. -M., Lee, D., Chua, T. -K., Tan, J. J. L., Lee, C. Y. P., Liu, X., . . . Ng, L. F. P. (2018). Zika Virus Infection Preferentially Counterbalances Human Peripheral Monocyte and/or NK Cell Activity. MSPHERE, 3(2), 18 pages. doi:10.1128/mSphereDirect.00120-18
2017
IMPROVING THE DIAGNOSIS OF ENCEPHALITIS THROUGH EXAMINING HOST PROTEOME AND GENE EXPRESSION
Ellul, M., Griffiths, M., Hiscox, J., & Solomon, T. (2017). IMPROVING THE DIAGNOSIS OF ENCEPHALITIS THROUGH EXAMINING HOST PROTEOME AND GENE EXPRESSION. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 88 (pp. A55-A56). doi:10.1136/jnnp-2017-ABN.191
Immunopathogenesis and Virus-Host Interactions of Enterovirus 71 in Patients with Hand, Foot and Mouth Disease
Cox, J. A., Hiscox, J. A., Solomon, T., Ooi, M. -H., & Ng, L. F. P. (2017). Immunopathogenesis and Virus-Host Interactions of Enterovirus 71 in Patients with Hand, Foot and Mouth Disease. FRONTIERS IN MICROBIOLOGY, 8. doi:10.3389/fmicb.2017.02249
Zika virus infection preferentially counterbalances human peripheral monocyte and/or NK-cell activity
Deep Sequencing of RNA from Blood and Oral Swab Samples Reveals the Presence of Nucleic Acid from a Number of Pathogens in Patients with Acute Ebola Virus Disease and Is Consistent with Bacterial Translocation across the Gut
Carroll, M. W., Haldenby, S., Rickett, N. Y., Palyi, B., Garcia-Dorival, I., Liu, X., . . . Hiscox, J. A. (2017). Deep Sequencing of RNA from Blood and Oral Swab Samples Reveals the Presence of Nucleic Acid from a Number of Pathogens in Patients with Acute Ebola Virus Disease and Is Consistent with Bacterial Translocation across the Gut. MSPHERE, 2(04), 19 pages. doi:10.1128/mSphereDirect.00325-17
Deep sequencing of RNA from blood and oral swab samples reveals the presence of nucleic acid from a number of pathogens in patients with acute Ebola virus disease and is consistent with bacterial translocation across the gut
Carroll, M. W., Haldenby, S., Rickett, N. Y., Pályi, B., Garcia-Dorival, I., Liu, X., . . . Hiscox, J. A. (2017). Deep sequencing of RNA from blood and oral swab samples reveals the presence of nucleic acid from a number of pathogens in patients with acute Ebola virus disease and is consistent with bacterial translocation across the gut. mSphere, 2(4). doi:10.1128/mSphereDirect.00325-17
Virus genomes reveal factors that spread and sustained the Ebola epidemic
Dudas, G., Carvalho, L. M., Bedford, T., Tatem, A. J., Baele, G., Faria, N. R., . . . Rambaut, A. (2017). Virus genomes reveal factors that spread and sustained the Ebola epidemic. NATURE, 544(7650), 309-315. doi:10.1038/nature22040
Rabbit hepatitis E virus is an opportunistic pathogen in specific-pathogen-free rabbits with the capability of cross-species transmission
Liu, B., Sun, Y., Du, T., Chen, Y., Wang, X., Huan, B., . . . Zhao, Q. (2017). Rabbit hepatitis E virus is an opportunistic pathogen in specific-pathogen-free rabbits with the capability of cross-species transmission. VETERINARY MICROBIOLOGY, 201, 72-77. doi:10.1016/j.vetmic.2016.10.029
A comparison of host gene expression signatures associated with infection in vitro by the Makona and Ecran (Mayinga) variants of Ebola virus
Bosworth, A., Dowall, S. D., Garcia-Dorival, I., Rickett, N. Y., Bruce, C. B., Matthews, D. A., . . . Hiscox, J. A. (2017). A comparison of host gene expression signatures associated with infection in vitro by the Makona and Ecran (Mayinga) variants of Ebola virus. SCIENTIFIC REPORTS, 7. doi:10.1038/srep43144
Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus
Liu, X., Speranza, E., Muñoz-Fontela, C., Haldenby, S., Rickett, N., Garcia-Dorival, I., . . . Hiscox, J. (2017). Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus. Genome Biology, 18. doi:10.1186/s13059-016-1137-3
Heme oxygenase-1 metabolite biliverdin, not iron, inhibits porcine reproductive and respiratory syndrome virus replication
Zhang, A., Duan, H., Li, N., Zhao, L., Pu, F., Huang, B., . . . Xiao, S. (2017). Heme oxygenase-1 metabolite biliverdin, not iron, inhibits porcine reproductive and respiratory syndrome virus replication. FREE RADICAL BIOLOGY AND MEDICINE, 102, 149-161. doi:10.1016/j.freeradbiomed.2016.11.044
2016
Elucidation of the Cellular Interactome of Ebola Virus Nucleoprotein and Identification of Therapeutic Targets
Garcia-Dorival, I., Wu, W., Armstrong, S. D., Barr, J. N., Carroll, M. W., Hewson, R., & Hiscox, J. A. (2016). Elucidation of the Cellular Interactome of Ebola Virus Nucleoprotein and Identification of Therapeutic Targets. JOURNAL OF PROTEOME RESEARCH, 15(12), 4290-4303. doi:10.1021/acs.jproteome.6b00337
Antiviral Screening of Multiple Compounds against Ebola Virus
Dowall, S. D., Bewley, K., Watson, R. J., Vasan, S. S., Ghosh, C., Konai, M. M., . . . Carroll, M. W. (2016). Antiviral Screening of Multiple Compounds against Ebola Virus. VIRUSES-BASEL, 8(11). doi:10.3390/v8110277
Heat Shock Protein 70 Family Members Interact with Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus Nucleocapsid Proteins and Perform a Functional Role in the Nairovirus Replication Cycle
Surtees, R., Dowall, S. D., Shaw, A., Armstrong, S., Hewson, R., Carroll, M. W., . . . Barr, J. N. (2016). Heat Shock Protein 70 Family Members Interact with Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus Nucleocapsid Proteins and Perform a Functional Role in the Nairovirus Replication Cycle. JOURNAL OF VIROLOGY, 90(20), 9305-9316. doi:10.1128/JVI.00661-16
Determination of the interactome of non-structural protein12 from highly pathogenic porcine reproductive and respiratory syndrome virus with host cellular proteins using high throughput proteomics and identification of HSP70 as a cellular factor for virus replication
Dong, S., Liu, L., Wu, W., Armstrong, S. D., Xia, D., Nan, H., . . . Chen, H. (2016). Determination of the interactome of non-structural protein12 from highly pathogenic porcine reproductive and respiratory syndrome virus with host cellular proteins using high throughput proteomics and identification of HSP70 as a cellular factor for virus replication. JOURNAL OF PROTEOMICS, 146, 58-69. doi:10.1016/j.jprot.2016.06.019
Virus genomes reveal the factors that spread and sustained the West African Ebola epidemic
Influenza A Virus Challenge Models in Cynomolgus Macaques Using the Authentic Inhaled Aerosol and Intra-Nasal Routes of Infection
Marriott, A. C., Dennis, M., Kane, J. A., Gooch, K. E., Hatch, G., Sharpe, S., . . . Carroll, M. W. (2016). Influenza A Virus Challenge Models in Cynomolgus Macaques Using the Authentic Inhaled Aerosol and Intra-Nasal Routes of Infection. PLoS One, 11(6). doi:10.1371/journal.pone.0157887
Porcine Reproductive and Respiratory Syndrome Virus Nucleocapsid Protein Interacts with Nsp9 and Cellular DHX9 To Regulate Viral RNA Synthesis
Liu, L., Tian, J., Nan, H., Tian, M., Li, Y., Xu, X., . . . Chen, H. (2016). Porcine Reproductive and Respiratory Syndrome Virus Nucleocapsid Protein Interacts with Nsp9 and Cellular DHX9 To Regulate Viral RNA Synthesis. JOURNAL OF VIROLOGY, 90(11), 5384-5398. doi:10.1128/JVI.03216-15
Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach
Aljabr, W., Touzelet, O., Pollakis, G., Wu, W., Munday, D. C., Hughes, M., . . . Hiscox, J. A. (2016). Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach. JOURNAL OF VIROLOGY, 90(10), 4876-4888. doi:10.1128/JVI.02349-15
Characterization of the Interactome of the Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 2 Reveals the Hyper Variable Region as a Binding Platform for Association with 14-3-3 Proteins
Xiao, Y., Wu, W., Gao, J., Smith, N., Burkard, C., Xia, D., . . . Hiscox, J. A. (2016). Characterization of the Interactome of the Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 2 Reveals the Hyper Variable Region as a Binding Platform for Association with 14-3-3 Proteins. JOURNAL OF PROTEOME RESEARCH, 15(5), 1388-1401. doi:10.1021/acs.jproteome.5b00396
MYH9 is an Essential Factor for Porcine Reproductive and Respiratory Syndrome Virus Infection
Gao, J., Xiao, S., Xiao, Y., Wang, X., Zhang, C., Zhao, Q., . . . Zhou, E. -M. (2016). MYH9 is an Essential Factor for Porcine Reproductive and Respiratory Syndrome Virus Infection. SCIENTIFIC REPORTS, 6. doi:10.1038/srep25120
Real-time, portable genome sequencing for Ebola surveillance
Quick, J., Loman, N. J., Duraffour, S., Simpson, J. T., Severi, E., Cowley, L., . . . Carroll, M. W. (2016). Real-time, portable genome sequencing for Ebola surveillance. Nature, 530, 228-232. doi:10.1038/nature16996
2015
Intranasal inoculation of sows with highly pathogenic porcine reproductive and respiratory syndrome virus at mid-gestation causes transplacental infection of fetuses
Wang, T., Wang, X., Li, X. -A., Zhang, M., Liu, S., Zhao, X., . . . Xiao, Y. (2015). Intranasal inoculation of sows with highly pathogenic porcine reproductive and respiratory syndrome virus at mid-gestation causes transplacental infection of fetuses. VETERINARY RESEARCH, 46. doi:10.1186/s13567-015-0283-z
The crystal structure of the Hazara virus nucleocapsid protein
Surtees, R., Ariza, A., Punch, E. K., Trinh, C. H., Dowall, S. D., Hewson, R., . . . Edwards, T. A. (2015). The crystal structure of the Hazara virus nucleocapsid protein. BMC STRUCTURAL BIOLOGY, 15. doi:10.1186/s12900-015-0051-3
Human respiratory syncytial virus non-structural protein NS1 modifies miR-24 expression via transforming growth factor-β
Bakre, A., Wu, W., Hiscox, J., Spann, K., Teng, M. N., & Tripp, R. A. (2015). Human respiratory syncytial virus non-structural protein NS1 modifies miR-24 expression via transforming growth factor-β. JOURNAL OF GENERAL VIROLOGY, 96, 3179-3191. doi:10.1099/jgv.0.000261
Glycoprotein 5 of porcine reproductive and respiratory syndrome virus strain SD16 inhibits viral replication and causes G2/M cell cycle arrest, but does not induce cellular apoptosis in Marc-145 cells
Mu, Y., Li, L., Zhang, B., Huang, B., Gao, J., Wang, X., . . . Zhou, E. -M. (2015). Glycoprotein 5 of porcine reproductive and respiratory syndrome virus strain SD16 inhibits viral replication and causes G2/M cell cycle arrest, but does not induce cellular apoptosis in Marc-145 cells. VIROLOGY, 484, 136-145. doi:10.1016/j.virol.2015.05.019
Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa
Carroll, M. W., Matthews, D. A., Hiscox, J., Elmore, M. J., Pollakis, G., Rambaut, A., . . . Günther, S. (2015). Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa. Nature, 524(7563), 97-101. doi:10.1038/nature14594
MicroRNA miR-24-3p Promotes Porcine Reproductive and Respiratory Syndrome Virus Replication through Suppression of Heme Oxygenase-1 Expression
Xiao, S., Wang, X., Ni, H., Li, N., Zhang, A., Liu, H., . . . Zhou, E. -M. (2015). MicroRNA miR-24-3p Promotes Porcine Reproductive and Respiratory Syndrome Virus Replication through Suppression of Heme Oxygenase-1 Expression. JOURNAL OF VIROLOGY, 89(8), 4494-4503. doi:10.1128/JVI.02810-14
Resolution of the cellular proteome of the nucleocapsid protein from a highly pathogenic isolate of porcine reproductive and respiratory syndrome virus identifies PARP-1 as a cellular target whose interaction is critical for virus biology
Liu, L., Lear, Z., Hughes, D. J., Wu, W., Zhou, E. -M., Whitehouse, A., . . . Hiscox, J. A. (2015). Resolution of the cellular proteome of the nucleocapsid protein from a highly pathogenic isolate of porcine reproductive and respiratory syndrome virus identifies PARP-1 as a cellular target whose interaction is critical for virus biology. VETERINARY MICROBIOLOGY, 176(1-2), 109-119. doi:10.1016/j.vetmic.2014.11.023
Proteomic analysis of mitochondria in respiratory epithelial cells infected with human respiratory syncytial virus and functional implications for virus and cell biology
Munday, D. C., Howell, G., Barr, J. N., & Hiscox, J. A. (2015). Proteomic analysis of mitochondria in respiratory epithelial cells infected with human respiratory syncytial virus and functional implications for virus and cell biology. JOURNAL OF PHARMACY AND PHARMACOLOGY, 67(3), 300-318. doi:10.1111/jphp.12349
Interactome Analysis of the Human Respiratory Syncytial Virus RNA Polymerase Complex Identifies Protein Chaperones as Important Cofactors That Promote L-Protein Stability and RNA Synthesis
Munday, D. C., Wu, W., Smith, N., Fix, J., Noton, S. L., Galloux, M., . . . Hiscox, J. A. (2015). Interactome Analysis of the Human Respiratory Syncytial Virus RNA Polymerase Complex Identifies Protein Chaperones as Important Cofactors That Promote L-Protein Stability and RNA Synthesis. JOURNAL OF VIROLOGY, 89(2), 917-930. doi:10.1128/JVI.01783-14
2014
GP5 expression in Marc-145 cells inhibits porcine reproductive and respiratory syndrome virus infection by inducing beta interferon activity
Gao, J., Ji, P., Zhang, M., Wang, X., Li, N., Wang, C., . . . Zhou, E. -M. (2014). GP5 expression in Marc-145 cells inhibits porcine reproductive and respiratory syndrome virus infection by inducing beta interferon activity. VETERINARY MICROBIOLOGY, 174(3-4), 409-418. doi:10.1016/j.vetmic.2014.09.030
Elucidation of the Ebola Virus VP24 Cellular Interactome and Disruption of Virus Biology through Targeted Inhibition of Host-Cell Protein Function
Garcia-Dorival, I., Wu, W., Dowall, S., Armstrong, S., Touzelet, O., Wastling, J., . . . Hiscox, J. A. (2014). Elucidation of the Ebola Virus VP24 Cellular Interactome and Disruption of Virus Biology through Targeted Inhibition of Host-Cell Protein Function. JOURNAL OF PROTEOME RESEARCH, 13(11), 5120-5135. doi:10.1021/pr500556d
Anti-idiotypic antibodies reduce efficacy of the attenuated vaccine against highly pathogenic PRRSV challenge
Yu, Y., Cai, X., Wang, G., Kong, N., Liu, Y., Xiao, Y., . . . Zhou, E. -M. (2014). Anti-idiotypic antibodies reduce efficacy of the attenuated vaccine against highly pathogenic PRRSV challenge. BMC VETERINARY RESEARCH, 10. doi:10.1186/1746-6148-10-39
Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation
Tanner, S. J., Ariza, A., Richard, C. -A., Kyle, H. F., Dods, R. L., Blondot, M. -L., . . . Barr, J. N. (2014). Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(4), 1580-1585. doi:10.1073/pnas.1317262111
Elucidating variations in the nucleotide sequence of Ebola virus associated with increasing pathogenicity
Dowall, S. D., Matthews, D. A., Garcia-Dorival, I., Taylor, I., Kenny, J., Hertz-Fowler, C., . . . Hiscox, J. A. (2014). Elucidating variations in the nucleotide sequence of Ebola virus associated with increasing pathogenicity. GENOME BIOLOGY, 15(11). doi:10.1186/s13059-014-0540-x
Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host cell protein function.
GarcÃa-Dorival, I., Wu, W., Dowall, S., Armstrong, S., Touzelet, O., Wastling, J., . . . Hiscox, J. A. (2014). Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host cell protein function.. Journal of Proteome Research.
Factors affecting <i>de novo</i> RNA synthesis and back-priming by the respiratory syncytial virus polymerase
Noton, S. L., Aljabr, W., Hiscox, J. A., Matthews, D. A., & Fearns, R. (2014). Factors affecting <i>de novo</i> RNA synthesis and back-priming by the respiratory syncytial virus polymerase. VIROLOGY, 462, 318-327. doi:10.1016/j.virol.2014.05.032
Heme oxygenase-1 acts as an antiviral factor for porcine reproductive and respiratory syndrome virus infection and over-expression inhibits virus replication <i>in vitro</i>
Xiao, S., Zhang, A., Zhang, C., Ni, H., Gao, J., Wang, C., . . . Zhou, E. -M. (2014). Heme oxygenase-1 acts as an antiviral factor for porcine reproductive and respiratory syndrome virus infection and over-expression inhibits virus replication <i>in vitro</i>. ANTIVIRAL RESEARCH, 110, 60-69. doi:10.1016/j.antiviral.2014.07.011
Heme oxygenase-1 acts as an antiviral factor for porcine reproductive and respiratory syndrome virus infection and over-expression inhibits virus replication in vitro.
Xiao, S., Zhang, A., Zhang, C., Ni, H., Gao, J., Wang, C., . . . Zhou, E. M. (2014). Heme oxygenase-1 acts as an antiviral factor for porcine reproductive and respiratory syndrome virus infection and over-expression inhibits virus replication in vitro.. Anti-viral research, 110, 60-69.
2013
Characterization of antigenic domains and epitopes in the ORF3 protein of a Chinese isolate of avian hepatitis E virus
Zhao, Q., Sun, Y. -N., Hu, S. -B., Wang, X. -J., Xiao, Y. -H., Hsu, W. H., . . . Zhou, E. -M. (2013). Characterization of antigenic domains and epitopes in the ORF3 protein of a Chinese isolate of avian hepatitis E virus. VETERINARY MICROBIOLOGY, 167(3-4), 242-249. doi:10.1016/j.vetmic.2013.08.006
PK-15 cells transfected with porcine CD163 by PiggyBac transposon system are susceptible to porcine reproductive and respiratory syndrome virus
Wang, X., Wei, R., Li, Q., Liu, H., Huang, B., Gao, J., . . . Zhou, E. -M. (2013). PK-15 cells transfected with porcine CD163 by PiggyBac transposon system are susceptible to porcine reproductive and respiratory syndrome virus. JOURNAL OF VIROLOGICAL METHODS, 193(2), 383-390. doi:10.1016/j.jviromet.2013.06.035
The Cellular Interactome of the Coronavirus Infectious Bronchitis Virus Nucleocapsid Protein and Functional Implications for Virus Biology
Emmott, E., Munday, D., Bickerton, E., Britton, P., Rodgers, M. A., Whitehouse, A., . . . Hiscox, J. A. (2013). The Cellular Interactome of the Coronavirus Infectious Bronchitis Virus Nucleocapsid Protein and Functional Implications for Virus Biology. JOURNAL OF VIROLOGY, 87(17), 9486-9500. doi:10.1128/JVI.00321-13
The Asymmetric Structure of an Icosahedral Virus Bound to Its Receptor Suggests a Mechanism for Genome Release
Dent, K. C., Thompson, R., Barker, A. M., Hiscox, J. A., Barr, J. N., Stockley, P. G., & Ranson, N. A. (2013). The Asymmetric Structure of an Icosahedral Virus Bound to Its Receptor Suggests a Mechanism for Genome Release. STRUCTURE, 21(7), 1225-1234. doi:10.1016/j.str.2013.05.012
Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization
Ariza, A., Tanner, S. J., Walter, C. T., Dent, K. C., Shepherd, D. A., Wu, W., . . . Edwards, T. A. (2013). Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization. NUCLEIC ACIDS RESEARCH, 41(11), 5912-+. doi:10.1093/nar/gkt268
2012
Structure, Function, and Evolution of the Crimean-Congo Hemorrhagic Fever Virus Nucleocapsid Protein
Carter, S. D., Surtees, R., Walter, C. T., Ariza, A., Bergeron, E., Nichol, S. T., . . . Barr, J. N. (2012). Structure, Function, and Evolution of the Crimean-Congo Hemorrhagic Fever Virus Nucleocapsid Protein. JOURNAL OF VIROLOGY, 86(20), 10914-10923. doi:10.1128/JVI.01555-12
The Interactome of the Human Respiratory Syncytial Virus NS1 Protein Highlights Multiple Effects on Host Cell Biology
Wu, W., Tran, K. C., Teng, M. N., Heesom, K. J., Matthews, D. A., Barr, J. N., & Hiscox, J. A. (2012). The Interactome of the Human Respiratory Syncytial Virus NS1 Protein Highlights Multiple Effects on Host Cell Biology. JOURNAL OF VIROLOGY, 86(15), 7777-7789. doi:10.1128/JVI.00460-12
A quantitative proteomic analysis of lung epithelial (A549) cells infected with 2009 pandemic influenza A virus using stable isotope labelling with amino acids in cell culture
Dove, B. K., Surtees, R., Bean, T. J. H., Munday, D., Wise, H. M., Digard, P., . . . Hiscox, J. A. (2012). A quantitative proteomic analysis of lung epithelial (A549) cells infected with 2009 pandemic influenza A virus using stable isotope labelling with amino acids in cell culture. PROTEOMICS, 12(9), 1431-1436. doi:10.1002/pmic.201100470
An interactome map of the nucleocapsid protein from a highly pathogenic North American porcine reproductive and respiratory syndrome virus strain generated using SILAC-based quantitative proteomics
Jourdan, S. S., Osorio, F., & Hiscox, J. A. (2012). An interactome map of the nucleocapsid protein from a highly pathogenic North American porcine reproductive and respiratory syndrome virus strain generated using SILAC-based quantitative proteomics. PROTEOMICS, 12(7), 1015-1023. doi:10.1002/pmic.201100469
Biophysical characterisation of the nucleocapsid protein from a highly pathogenic porcine reproductive and respiratory syndrome virus strain
Jourdan, S. S., Osorio, F. A., & Hiscox, J. A. (2012). Biophysical characterisation of the nucleocapsid protein from a highly pathogenic porcine reproductive and respiratory syndrome virus strain. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 419(2), 137-141. doi:10.1016/j.bbrc.2011.11.126
Different NF-κB activation characteristics of human respiratory syncytial virus subgroups A and B
Wu, W., Macdonald, A., Hiscox, J. A., & Barr, J. N. (2012). Different NF-κB activation characteristics of human respiratory syncytial virus subgroups A and B. MICROBIAL PATHOGENESIS, 52(3), 184-191. doi:10.1016/j.micpath.2011.12.006
Using SILAC and quantitative proteomics to investigate the interactions between viral and host proteomes
Munday, D. C., Surtees, R., Emmott, E., Dove, B. K., Digard, P., Barr, J. N., . . . Hiscox, J. A. (2012). Using SILAC and quantitative proteomics to investigate the interactions between viral and host proteomes. PROTEOMICS, 12(4-5), 666-672. doi:10.1002/pmic.201100488
2011
Nucleolar NF-κB/RelA mediates apoptosis by causing cytoplasmic relocalization of nucleophosmin
Khandelwal, N., Simpson, J., Taylor, G., Rafique, S., Whitehouse, A., Hiscox, J., & Stark, L. A. (2011). Nucleolar NF-κB/RelA mediates apoptosis by causing cytoplasmic relocalization of nucleophosmin. CELL DEATH AND DIFFERENTIATION, 18(12), 1889-1903. doi:10.1038/cdd.2011.79
Characterization of the Interaction between Human Respiratory Syncytial Virus and the Cell Cycle in Continuous Cell Culture and Primary Human Airway Epithelial Cells
Wu, W., Munday, D. C., Howell, G., Platt, G., Barr, J. N., & Hiscox, J. A. (2011). Characterization of the Interaction between Human Respiratory Syncytial Virus and the Cell Cycle in Continuous Cell Culture and Primary Human Airway Epithelial Cells. JOURNAL OF VIROLOGY, 85(19), 10300-10309. doi:10.1128/JVI.05164-11
Viruses and the Nucleolus
Matthews, D., Emmott, E., & Hiscox, J. (2011). Viruses and the Nucleolus. NUCLEOLUS, 15, 321-345. doi:10.1007/978-1-4614-0514-6_14
2010
Quantitative proteomic analysis of A549 cells infected with human respiratory syncytial virus subgroup B using SILAC coupled to LC-MS/MS
Munday, D. C., Hiscox, J. A., & Barr, J. N. (2010). Quantitative proteomic analysis of A549 cells infected with human respiratory syncytial virus subgroup B using SILAC coupled to LC-MS/MS. PROTEOMICS, 10(23), 4320-4334. Retrieved from https://www.webofscience.com/
Nucleolar proteomics and viral infection
Hiscox, J. A., Whitehouse, A., & Matthews, D. A. (2010). Nucleolar proteomics and viral infection. PROTEOMICS, 10(22), 4077-4086. doi:10.1002/pmic.201000251
Quantitative Proteomic Analysis of A549 Cells Infected with Human Respiratory Syncytial Virus
Munday, D. C., Emmott, E., Surtees, R., Lardeau, C. -H., Wu, W., Duprex, W. P., . . . Hiscox, J. A. (2010). Quantitative Proteomic Analysis of A549 Cells Infected with Human Respiratory Syncytial Virus. MOLECULAR & CELLULAR PROTEOMICS, 9(11), 2438-2459. doi:10.1074/mcp.M110.001859
Elucidation of the avian nucleolar proteome by quantitative proteomics using SILAC and changes in cells infected with the coronavirus infectious bronchitis virus
Emmott, E., Smith, C., Emmett, S. R., Dove, B. K., & Hiscox, J. A. (2010). Elucidation of the avian nucleolar proteome by quantitative proteomics using SILAC and changes in cells infected with the coronavirus infectious bronchitis virus. PROTEOMICS, 10(19), 3558-3562. doi:10.1002/pmic.201000139
Quantitative Proteomics Using SILAC Coupled to LC-MS/MS Reveals Changes in the Nucleolar Proteome in Influenza A Virus-Infected Cells
Emmott, E., Wise, H., Loucaides, E. M., Matthews, D. A., Digard, P., & Hiscox, J. A. (2010). Quantitative Proteomics Using SILAC Coupled to LC-MS/MS Reveals Changes in the Nucleolar Proteome in Influenza A Virus-Infected Cells. JOURNAL OF PROTEOME RESEARCH, 9(10), 5335-5345. doi:10.1021/pr100593g
Quantitative Proteomics Using Stable Isotope Labeling with Amino Acids in Cell Culture Reveals Changes in the Cytoplasmic, Nuclear, and Nucleolar Proteomes in Vero Cells Infected with the Coronavirus Infectious Bronchitis Virus
Emmott, E., Rodgers, M. A., Macdonald, A., McCrory, S., Ajuh, P., & Hiscox, J. A. (2010). Quantitative Proteomics Using Stable Isotope Labeling with Amino Acids in Cell Culture Reveals Changes in the Cytoplasmic, Nuclear, and Nucleolar Proteomes in Vero Cells Infected with the Coronavirus Infectious Bronchitis Virus. MOLECULAR & CELLULAR PROTEOMICS, 9(9), 1920-1936. doi:10.1074/mcp.M900345-MCP200
Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability
Carter, S. D., Dent, K. C., Atkins, E., Foster, T. L., Verow, M., Gorny, P., . . . Barr, J. N. (2010). Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability. FEBS LETTERS, 584(13), 2786-2790. doi:10.1016/j.febslet.2010.05.006
2009
Nucleolar targeting: the hub of the matter
Emmott, E., & Hiscox, J. A. (2009). Nucleolar targeting: the hub of the matter. EMBO REPORTS, 10(3), 231-238. doi:10.1038/embor.2009.14
2008
Viral nucleolar localisation signals determine dynamic trafficking within the nucleolus
Emmott, E., Dove, B. K., Howell, G., Chappell, L. A., Reed, M. L., Boyne, J. R., . . . Hiscox, J. A. (2008). Viral nucleolar localisation signals determine dynamic trafficking within the nucleolus. VIROLOGY, 380(2), 191-202. doi:10.1016/j.virol.2008.05.032
A model for the dynamic nuclear/nucleolar/cytoplasmic trafficking of the porcine reproductive and respiratory syndrome virus (PRRSV) nucleocapsid protein based on live cell imaging
You, J. -H., Howell, G., Pattnaik, A. K., Osorio, F. A., & Hiscox, J. A. (2008). A model for the dynamic nuclear/nucleolar/cytoplasmic trafficking of the porcine reproductive and respiratory syndrome virus (PRRSV) nucleocapsid protein based on live cell imaging. VIROLOGY, 378(1), 34-47. doi:10.1016/j.virol.2008.04.037
Production of an infectious Herpesvirus saimiri-based episomally maintained amplicon system
Macnab, S., White, R., Hiscox, J., & Whitehouse, A. (2008). Production of an infectious Herpesvirus saimiri-based episomally maintained amplicon system. JOURNAL OF BIOTECHNOLOGY, 134(3-4), 287-296. doi:10.1016/j.jbiotec.2008.01.012
Role of phosphorylation clusters in the biology of the coronavirus infectious bronchitis virus nucleocapsid protein
Spencer, K. -A., Dee, M., Britton, P., & Hiscox, J. A. (2008). Role of phosphorylation clusters in the biology of the coronavirus infectious bronchitis virus nucleocapsid protein. VIROLOGY, 370(2), 373-381. doi:10.1016/j.virol.2007.08.016
2007
Recombinant viral proteins for use in diagnostic ELISAs to detect virus infection
Spencer, K. -A., Osori, F. A., & Hiscox, J. A. (2007). Recombinant viral proteins for use in diagnostic ELISAs to detect virus infection. VACCINE, 25(30), 5653-5659. doi:10.1016/j.vaccine.2007.02.053
Trafficking motifs in the SARS-coronavirus nucleocapsid protein
You, J. -H., Reed, M. L., & Hiscox, J. A. (2007). Trafficking motifs in the SARS-coronavirus nucleocapsid protein. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 358(4), 1015-1020. doi:10.1016/j.bbrc.2007.05.036
Characterization of the nuclear export signal in the coronavirus infectious bronchitis virus nucleocapsid protein
Reed, M. L., Howell, G., Harrison, S. M., Spencer, K. -A., & Hiscox, J. A. (2007). Characterization of the nuclear export signal in the coronavirus infectious bronchitis virus nucleocapsid protein. JOURNAL OF VIROLOGY, 81(8), 4298-4304. doi:10.1128/JVI.02239-06
Characterisation of cyclin D1 down-regulation in coronavirus infected cells
Harrison, S. M., Dove, B. K., Rothwell, L., Kaiser, P., Tarpey, I., Brooks, G., & Hiscox, J. A. (2007). Characterisation of cyclin D1 down-regulation in coronavirus infected cells. FEBS LETTERS, 581(7), 1275-1286. doi:10.1016/j.febslet.2007.02.039
Cell cycle dependent nucleolar localization of the coronavirus nucleocapsid protein
Cawood, R., Harrison, S. M., Dove, B. K., Reed, M. L., & Hiscox, J. A. (2007). Cell cycle dependent nucleolar localization of the coronavirus nucleocapsid protein. CELL CYCLE, 6(7), 863-867. doi:10.4161/cc.6.7.4032
Lithium chloride inhibits the coronavirus infectious bronchitis virus in cell culture
Harrison, S. M., Tarpey, I., Rothwell, L., Kaiser, P., & Hiscox, J. A. (2007). Lithium chloride inhibits the coronavirus infectious bronchitis virus in cell culture. AVIAN PATHOLOGY, 36(2), 109-114. doi:10.1080/03079450601156083
RNA viruses: hijacking the dynamic nucleolus
Hiscox, J. A. (2007). RNA viruses: hijacking the dynamic nucleolus. NATURE REVIEWS MICROBIOLOGY, 5(2), 119-127. doi:10.1038/nrmicro1597
2006
Characterisation of the RNA binding properties of the coronavirus infectious bronchitis virus nucleocapsid protein amino-terminal region
Spencer, K. -A., & Hiscox, J. A. (2006). Characterisation of the RNA binding properties of the coronavirus infectious bronchitis virus nucleocapsid protein amino-terminal region. FEBS LETTERS, 580(25), 5993-5998. doi:10.1016/j.febslet.2006.09.052
Changes in nucleolar morphology and proteins during infection with the coronavirus infectious bronchitis virus
Dove, B. K., You, J. -H., Reed, M. L., Emmett, S. R., Brooks, G., & Hiscox, J. A. (2006). Changes in nucleolar morphology and proteins during infection with the coronavirus infectious bronchitis virus. CELLULAR MICROBIOLOGY, 8(7), 1147-1157. doi:10.1111/j.1462-5822.2006.00698.x
Delineation and modelling of a nucleolar retention signal in the coronavirus nucleocapsid protein
Reed, M. L., Dove, B. K., Jackson, R. M., Collins, R., Brooks, G., & Hiscox, J. A. (2006). Delineation and modelling of a nucleolar retention signal in the coronavirus nucleocapsid protein. TRAFFIC, 7(7), 833-848. doi:10.1111/j.1600-0854.2006.00424.x
Cell cycle perturbations induced by infection with the coronavirus infectious bronchitis virus and their effect on virus replication
Dove, B., Brooks, G., Bicknell, K., Wurm, T., & Hiscox, J. A. (2006). Cell cycle perturbations induced by infection with the coronavirus infectious bronchitis virus and their effect on virus replication. JOURNAL OF VIROLOGY, 80(8), 4147-4156. doi:10.1128/JVI.80.8.4147-4156.2006
Expression and structural analysis of infectious bronchitis virus nucleoprotein
Spencer, K. -A., & Hiscox, J. A. (2006). Expression and structural analysis of infectious bronchitis virus nucleoprotein. NIDOVIRUSES: TOWARD CONTROL OF SARS AND OTHER NIDOVIRUS DISEASES, 581, 133-138. Retrieved from https://www.webofscience.com/
Infectious bronchitis coronavirus induces cell-cycle perturbations
Dove, B. K., Bicknell, K., Brooks, G., Harrison, S., & Hiscox, J. A. (2006). Infectious bronchitis coronavirus induces cell-cycle perturbations. NIDOVIRUSES: TOWARD CONTROL OF SARS AND OTHER NIDOVIRUS DISEASES, 581, 357-362. Retrieved from https://www.webofscience.com/
Three-dimensional reconstruction of the nucleolus using meta-confocal microscopy in cells expressing the coronavirus nucleoprotein
You, J. -H., Reed, M. L., Dove, B. K., & Hiscox, J. A. (2006). Three-dimensional reconstruction of the nucleolus using meta-confocal microscopy in cells expressing the coronavirus nucleoprotein. NIDOVIRUSES: TOWARD CONTROL OF SARS AND OTHER NIDOVIRUS DISEASES, 581, 313-318. Retrieved from https://www.webofscience.com/
2005
Subcellular localization of the severe acute respiratory syndrome coronavirus nucleocapsid protein
You, J. W., Dove, B. K., Enjuanes, L., DeDiego, M. L., Alvarez, E., Howell, G., . . . Hiscox, J. A. (2005). Subcellular localization of the severe acute respiratory syndrome coronavirus nucleocapsid protein. JOURNAL OF GENERAL VIROLOGY, 86, 3303-3310. doi:10.1099/vir.0.81076-0
Nucleolin is regulated both at the level of transcription and translation
Bicknell, K., Brooks, G., Kaiser, P., Chen, H. Y., Dove, B. K., & Hiscox, J. A. (2005). Nucleolin is regulated both at the level of transcription and translation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 332(3), 817-822. doi:10.1016/j.bbrc.2005.05.022
Mass spectroscopic characterization of the coronavirus infectious bronchitis virus nucleoprotein and elucidation of the role of phosphorylation in RNA binding by using surface plasmon resonance
Chen, H. Y., Gill, A., Dove, B. K., Emmett, S. R., Kemp, C. F., Ritchie, M. A., . . . Hiscox, J. A. (2005). Mass spectroscopic characterization of the coronavirus infectious bronchitis virus nucleoprotein and elucidation of the role of phosphorylation in RNA binding by using surface plasmon resonance. JOURNAL OF VIROLOGY, 79(2), 1164-1179. doi:10.1128/JVI.79.2.1164-1179.2005
The cell cycle and virus infection.
Emmett, S. R., Dove, B., Mahoney, L., Wurm, T., & Hiscox, J. A. (2005). The cell cycle and virus infection.. Methods in molecular biology (Clifton, N.J.), 296, 197-218. doi:10.1385/1-59259-857-9:197
2004
ACE2: from vasopeptidase to SARS virus receptor
Turner, A. J., Hiscox, J. A., & Hooper, N. M. (2004). ACE2: from vasopeptidase to SARS virus receptor. TRENDS IN PHARMACOLOGICAL SCIENCES, 25(6), 291-294. doi:10.1016/j.tips.2004.04.001
2003
Evaluation of a nucleoprotein-based enzyme-linked immunosorbent assay for the detection of antibodies against infectious bronchitis virus
Chen, H. Y., Coote, B., Attree, S., & Hiscox, J. A. (2003). Evaluation of a nucleoprotein-based enzyme-linked immunosorbent assay for the detection of antibodies against infectious bronchitis virus. AVIAN PATHOLOGY, 32(5), 519-526. doi:10.1080/0307945031000154125
The interaction of animal cytoplasmic RNA viruses with the nucleus to facilitate replication
Hiscox, J. A. (2003). The interaction of animal cytoplasmic RNA viruses with the nucleus to facilitate replication. VIRUS RESEARCH, 95(1-2), 13-22. doi:10.1016/S0168-1702(03)00160-6
2002
The nucleolus - a gateway to viral infection?
Hiscox, J. A. (2002). The nucleolus - a gateway to viral infection?. ARCHIVES OF VIROLOGY, 147(6), 1077-1089. doi:10.1007/s00705-001-0792-0
Interaction of the coronavirus nucleoprotein with nucleolar antigens and the host cell
Chen, H. Y., Wurm, T., Britton, P., Brooks, G., & Hiscox, J. A. (2002). Interaction of the coronavirus nucleoprotein with nucleolar antigens and the host cell. JOURNAL OF VIROLOGY, 76(10), 5233-5250. doi:10.1128/JVI.76.10.5233-5250.2002
2001
Localization to the nucleolus is a common feature of coronavirus nucleoproteins, and the protein may disrupt host cell division
Wurm, T., Chen, H. Y., Hodgson, T., Britton, P., Brooks, G., & Hiscox, J. A. (2001). Localization to the nucleolus is a common feature of coronavirus nucleoproteins, and the protein may disrupt host cell division. JOURNAL OF VIROLOGY, 75(19), 9345-9356. doi:10.1128/JVI.75.19.9345-9356.2001
Enhancement of defective RNA expression vectors as potential vaccine delivery systems for avian infectious bronchitis virus
Dove, B., Shaw, K., Hiscox, J., Cavanagh, D., & Britton, P. (2001). Enhancement of defective RNA expression vectors as potential vaccine delivery systems for avian infectious bronchitis virus. NIDOVIRUSES (CORONAVIRUSES AND ARTERIVIRUSES), 494, 407-409. Retrieved from https://www.webofscience.com/
The coronavirus infectious bronchitis virus nucleoprotein localizes to the nucleolus
Hiscox, J. A., Wurm, T., Wilson, L., Britton, P., Cavanagh, D., & Brooks, G. (2001). The coronavirus infectious bronchitis virus nucleoprotein localizes to the nucleolus. JOURNAL OF VIROLOGY, 75(1), 506-512. doi:10.1128/JVI.75.1.506-512.2001
1997
Cotranslational disassembly of flock house virus in a cell-free system
Hiscox, J. A., & Ball, L. A. (1997). Cotranslational disassembly of flock house virus in a cell-free system. JOURNAL OF VIROLOGY, 71(10), 7974-7977. doi:10.1128/JVI.71.10.7974-7977.1997
1995
Characterization of the transmissible gastroenteritis virus (TGEV) transcription initiation sequence. Characterization of TGEV TIS.
Hiscox, J. A., Mawditt, K. L., Cavanagh, D., & Britton, P. (1995). Characterization of the transmissible gastroenteritis virus (TGEV) transcription initiation sequence. Characterization of TGEV TIS.. Advances in experimental medicine and biology, 380, 529-535. doi:10.1007/978-1-4615-1899-0_84
INVESTIGATION OF THE CONTROL OF CORONAVIRUS SUBGENOMIC MESSENGER-RNA TRANSCRIPTION BY USING T7-GENERATED NEGATIVE-SENSE RNA TRANSCRIPTS
HISCOX, J. A., MAWDITT, K. L., CAVANAGH, D., & BRITTON, P. (1995). INVESTIGATION OF THE CONTROL OF CORONAVIRUS SUBGENOMIC MESSENGER-RNA TRANSCRIPTION BY USING T7-GENERATED NEGATIVE-SENSE RNA TRANSCRIPTS. JOURNAL OF VIROLOGY, 69(10), 6219-6227. doi:10.1128/JVI.69.10.6219-6227.1995
QUANTIFICATION OF INDIVIDUAL SUBGENOMIC MESSENGER-RNA SPECIES DURING REPLICATION OF THE CORONAVIRUS TRANSMISSIBLE GASTROENTERITIS VIRUS
HISCOX, J. A., CAVANAGH, D., & BRITTON, P. (1995). QUANTIFICATION OF INDIVIDUAL SUBGENOMIC MESSENGER-RNA SPECIES DURING REPLICATION OF THE CORONAVIRUS TRANSMISSIBLE GASTROENTERITIS VIRUS. VIRUS RESEARCH, 36(2-3), 119-130. doi:10.1016/0168-1702(94)00108-O
1994
Control of TGEV mRNA transcription.
Hiscox, J., Pocock, D. H., & Britton, P. (1993). Control of TGEV mRNA transcription.. Advances in experimental medicine and biology, 342, 99-104. doi:10.1007/978-1-4615-2996-5_16
Undated
Mechanisms and Stages of Covid-19 Immunopathology Revealed by Tissue-Specific Proteomes
Russell, C. D., Valanciute, A., Gachanja, N. N., Stephen, J., Penrice-Randal, R., Armstrong, S. D., . . . Lucas, C. D. (n.d.). Mechanisms and Stages of Covid-19 Immunopathology Revealed by Tissue-Specific Proteomes.