Research
Research Interest 1
Cell and molecular biology of bone.
Research grants
Bone anabolic effects of low dose parathyroid hormone.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
October 2005 - September 2006
ICAC (Integrated Clinical Arthritis Centre) Grant.
ARTHRITIS RESEARCH CAMPAIGN
April 2002 - October 2004
Investigating the mechanisms of ATP release and interconversion from osteoblasts.
ARTHRITIS RESEARCH CAMPAIGN
May 2006 - January 2010
Regulation of P2Y receptor-mediated Ca2+ transients by membrane potential in arterial smooth muscle cells.
BRITISH HEART FOUNDATION (UK)
February 2005 - January 2007
Investigation of how extracellular nucleotides synergise with growth factors to stimulate gene expression, cell proliferation and neoplastic progression
NORTH WEST CANCER RESEARCH FUND
April 1998 - December 2001
Find AKUre.
THE ALKAPTONURIA SOCIETY (UK)
May 2009 - May 2013
ATPBone—Fighting osteoporosis by blocking nucleotides: purinergic signalling in bone formation and homeostasis
EUROPEAN COMMISSION
January 2008 - December 2010
Establishment of an advanced electron microscopy unit.
WELLCOME TRUST (UK)
August 2004 - October 2009
The Pathogenesis of Tissue Damage in Alkaptonuria
THE ALKAPTONURIA SOCIETY (UK)
August 2006 - August 2007
High resolution analysis of phenotype in manipulated complex tissues.
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
November 2003 - November 2004
A preclinical feasibility study using recombinant homogentisic acid dehydrogenase as an enzyme replacement therapy for Alkaptonuria
WELLCOME TRUST (UK)
June 2014 - May 2015
Nociceptive purinergic P2X receptors in equine laminae and nerves – potential molecular targets for treating laminitis
PET PLAN CHARITABLE TRUST (UK)
October 2009 - September 2010
Effects of ultrasound on ATP release from human osteoblasts in vitro.
WRIGHTINGTON, WIGAN AND LEIGH NHS FOUNDATION TRUST (UK)
March 2005 - August 2005
ATP Binding Cassette (ABC) Transporters in Bone.
MEDICAL RESEARCH COUNCIL
September 2000 - August 2003
Academic Secretary Grant.
ARTHRITIS RESEARCH CAMPAIGN
April 1999 - April 2002
Investigation of the Mechanisms of Synergy and Consequences of Co-activation of Osteoblasts by Parathyroid Hormone and Extracellular Nucleotides.
ARTHRITIS RESEARCH CAMPAIGN
December 2001 - January 2005
Alkaptonuria PhD student
THE ALKAPTONURIA SOCIETY (UK)
October 2007 - March 2011
DevelopAKUre - Clinical Development of Nitisinone for Alkaptonuria
EUROPEAN COMMISSION
November 2012 - January 2019
Investigation of isoform-specific effects of PTHrP (1-173) in human osteoblasts.
ACTION MEDICAL RESEARCH (UK)
December 1998 - December 2001
Initiating events in the pigmentation of connective tissues that is the basis of the genetic disease Alkaptonuria
CHILDWICK TRUST
January 2013 - December 2015
Advanced Study of AKU in the Hgd-/-Mouse
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
July 2014 - December 2020
Administration of B.N.A.
BRITISH NEUROSCIENCE ASSOCIATION (UK)
October 1997 - August 2011
The expression and functional significance of P2 receptor subtypes in normal and pathological bone.
ARTHRITIS RESEARCH CAMPAIGN
October 1999 - September 2004
Assessment of Ochronosis in Ear Biopsies in AKU Patients
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
June 2012 - December 2025
Assessment of Disease Progress in the Rare Disease Alkaptonuria by Quantitative Image Analysis
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
November 2014 - June 2020