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Ian Prior

Professor Ian Prior

Associate Pro Vice Chancellor, Technology Infrastructure and Environment Directorate (HLS) and NWCR Professor of Molecular Oncology
Molecular & Clinical Cancer Medicine

Research

Mechanisms underpinning adaptive and acquired resistance to direct KRAS inhibitors

The role of codon bias in KRAS oncogenicity

Analysis of endogenous Ras isoform and mutation-specific signalling

Research grants

A novel in vivo model for studying Ras-driven cancer

NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

January 2022 - July 2025

A cellenONE BSC to enhance UK capability for single-cell proteomics

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

July 2022 - July 2023

Four year PhD Programme (2007)

WELLCOME TRUST (UK)

October 2007 - September 2011

North West Cancer Research Bid

NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

January 2018 - September 2023

Improved Digital Imaging for Liverpool Biomedical Electron Microscopy

NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

March 2019 - March 2020

Kinomic reprogramming during clonal evolution and therapy resistance in chronic lymphocytic leukaemia

LEUKA (UK)

September 2018 - December 2020

Wellcome Trust Four-Year PhD Studentship Programme

WELLCOME TRUST (UK)

October 2017 - March 2022

Absolute quantitation of endogenous Ras isoform protein abundance: Does codon bias explain the predominance of KRAS mutations in cancer?

NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

June 2018 - November 2020

Translating discovery science: DUBs that regulate centrosome clustering, an Achilles' heel of cancer

BREAST CANCER NOW (UK)

October 2019 - March 2024

Kinome profiling and mass cytometry as tools to detect rewiring of B cell receptor signalling in the malignant cells of chronic lymphocytic leukaemia patients taking ibrutinib

NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

March 2019 - September 2022

Wellcome Trust Four-year PhD Studentship 2016

WELLCOME TRUST (UK)

October 2016 - April 2021

Development of novel multiplex single-colour Ras GTPase sensor to compare spatio-temporal features of ras signalling cascades with subcellular resolution.

NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

August 2016 - August 2019

The North West Cancer Bioinformatics Fellowship

NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

October 2015 - September 2018

Kinome reprogramming in response to activating KRAS mutations and Ras pathway therapeutics CASE

ASTRAZENECA LIMITED (UK)

October 2015 - September 2019

Wellcome Trust Four-Year PhD Studentship with the Cellular and Molecular Physiology PhD Programme

WELLCOME TRUST (UK)

October 2015 - September 2019

Liverpool 3View: a national hub for 3D-EM bioscience research

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

January 2014 - December 2014

Why are Ras isoforms not redundant? Characterising isoform-specific oncogenic Ras signalling networks

NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

January 2015 - December 2017

YEAR 1 (part2) Wellcome Trust ISSF Non-Clinical Fellowships

WELLCOME TRUST (UK)

October 2012 - March 2023

Analysis of Ras isoform-specific signalling using RNAi.

ROYAL SOCIETY (CHARITABLE)

August 2005 - April 2006

Analysis of endogenous isoform-specific Ras signalling: summer vacation studentship grant for Rebecca Lea

BIOCHEMICAL SOCIETY (UK)

June 2014 - August 2014

Wellcome Trust Four Year PhD Studentship with the PhD Programme in Cellular and Molecular Physiology - 2009

WELLCOME TRUST (UK)

October 2009 - March 2014

Analysis of Ras isoform-specific signalling.

CANCER RESEARCH UK (UK)

June 2006 - May 2008

Establishment of an advanced electron microscopy unit.

WELLCOME TRUST (UK)

August 2004 - October 2009

miRNA profiling in isogenic cell lines and contingencies on deubiquitinase activity

CANCER RESEARCH UK (UK)

April 2012 - March 2013

Spatial regulation of signalling networks: analysis of Ras compartment-specific signalling

WELLCOME TRUST (UK)

March 2009 - March 2012

Wellcome Trust four year PhD studentship with the Cellular and Molecular Physiology Programme

WELLCOME TRUST (UK)

October 2013 - September 2017

Wellcome Trust Four Year PhD Studentship with the PhD Programme in Cellular and Molecular Physiology - 2010

WELLCOME TRUST (UK)

October 2010 - March 2015

Liverpool Imaging Partnership: Molecular physiology and drug response

MEDICAL RESEARCH COUNCIL

February 2013 - February 2017

Characterising isoform-specific oncogenic KRAS4A and KRAS4B signalling

NORTH WEST CANCER RESEARCH FUND

January 2013 - December 2014

Biomedical vacation scholarship for Alexandra Sheardown

WELLCOME TRUST (UK)

July 2012 - August 2012

Analysis of cell cycle and signaling pathways by quantitative mass spectroscopy.

CANCER RESEARCH UK (UK)

September 2008 - August 2009

Stretching the supply routes: ErbB2 gene amplification and endocytic recycling in metastatic breast cancer

BREAST CANCER NOW (UK)

January 2015 - January 2019

Nanoscale analysis of signalling domains regulating Ras activity.

NORTH WEST CANCER RESEARCH FUND

February 2005 - February 2008

Nanoscale characterisation of cell surface signalling domains.

ROYAL SOCIETY

October 2003 - September 2008

Characterising the Bruton's kinase signaling nexus in leukaemia

NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

September 2015 - September 2018

SILAC analysis of compartment-specific Ras signalling

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

November 2009 - November 2012

University of Liverpool Institutional Discipline Bridging.

MEDICAL RESEARCH COUNCIL

October 2003 - October 2006

Identifying and characterising negative regulators of oncogenic Ras signalling

NORTH WEST CANCER RESEARCH FUND

September 2008 - August 2011

Characterising compartmentalised Ras isoform signalling.

ROYAL SOCIETY

October 2008 - September 2011

Securing and enhancing Liverpool Biomedical EM cryo-preparation facilities

WELLCOME TRUST (UK)

July 2007 - June 2010

Inter-microtubule bridges in kinetochore fibres of the mitotic spindle

NORTH WEST CANCER RESEARCH FUND

January 2013 - December 2015