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Ian Prior

Professor Ian Prior

Associate Pro Vice Chancellor, Technology Infrastructure and Environment Directorate (HLS) and NWCR Professor of Molecular Oncology
Molecular & Clinical Cancer Medicine

Publications

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2024

2023

2022

2021

One-step preparation of antimicrobial silicone materials based on PDMS and salicylic acid: insights from spatially and temporally resolved techniques

Barbieri, L., Sorzabal Bellido, I., Beckett, A. J., Prior, I. A., Fothergill, J., Diaz Fernandez, Y. A., & Raval, R. (2021). One-step preparation of antimicrobial silicone materials based on PDMS and salicylic acid: insights from spatially and temporally resolved techniques. NPJ BIOFILMS AND MICROBIOMES, 7(1). doi:10.1038/s41522-021-00223-6

DOI
10.1038/s41522-021-00223-6
Journal article

2020

Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle

Badgujar, D., Anil, A., Green, A., Surve, M. V., Madhavan, S., Beckett, A., . . . Banerjee, A. (2020). Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle. doi:10.1101/2020.05.13.093682

DOI
10.1101/2020.05.13.093682
Journal article

Abstract A11: Screening the Ras proteome microenvironment using APEX2

Mo, S. P., Coulson, J. M., & Prior, I. A. (2020). Abstract A11: Screening the Ras proteome microenvironment using APEX2. Molecular Cancer Research, 18(5_Supplement), A11. doi:10.1158/1557-3125.ras18-a11

DOI
10.1158/1557-3125.ras18-a11
Journal article

Screening the Ras proteome microenvironment using APEX2.

Mo, S. P., Coulson, J. M., & Prior, I. A. (2020). Screening the Ras proteome microenvironment using APEX2.. In MOLECULAR CANCER RESEARCH Vol. 18 (pp. 38). Retrieved from https://www.webofscience.com/

Conference Paper

2019

Kinobead Profiling Reveals Reprogramming of B-cell Receptor Signaling in Response to Therapy Within Primary Chronic Lymphocytic Leukemia Cells

DOI
10.1101/841312
Preprint

Endocytic vacuoles in pancreatic acinar cells: actination, dynamics, rupture and exocytosis.

Voronina, S., De Faveri, F., Chvanov, M., Moore, D., Sherwood, M., Awais, M., . . . Tepikin, A. (2019). Endocytic vacuoles in pancreatic acinar cells: actination, dynamics, rupture and exocytosis.. Pancreatology, 19, S17. doi:10.1016/j.pan.2019.05.036

DOI
10.1016/j.pan.2019.05.036
Journal article

PF370 SIGNAL-OMICS ANALYSIS OF THE IMPACT OF THERAPY ON BCR SIGNALLING IN CHRONIC LYMPHOCYTIC LEUKAEMIA

Linley, A., Kalakonda, N., MacEwan, D., Prior, I., & Slupsky, J. (2019). PF370 SIGNAL-OMICS ANALYSIS OF THE IMPACT OF THERAPY ON BCR SIGNALLING IN CHRONIC LYMPHOCYTIC LEUKAEMIA. HemaSphere, 3(S1), 136-137. doi:10.1097/01.hs9.0000559692.06651.82

DOI
10.1097/01.hs9.0000559692.06651.82
Journal article

2018

RAS variant signalling

Mo, S. P., Coulson, J. M., & Prior, I. A. (2018). RAS variant signalling. BIOCHEMICAL SOCIETY TRANSACTIONS, 46, 1325-1332. doi:10.1042/BST20180173

DOI
10.1042/BST20180173
Journal article

Long-Chain n-3 Fatty Acids Attenuate Oncogenic KRas-Driven Proliferation by Altering Plasma Membrane Nanoscale Proteolipid Composition

Fuentes, N. R., Mlih, M., Barhoumi, R., Fan, Y. -Y., Hardin, P., Steele, T. J., . . . Chapkin, R. S. (2018). Long-Chain n-3 Fatty Acids Attenuate Oncogenic KRas-Driven Proliferation by Altering Plasma Membrane Nanoscale Proteolipid Composition. CANCER RESEARCH, 78(14), 3899-3912. doi:10.1158/0008-5472.CAN-18-0324

DOI
10.1158/0008-5472.CAN-18-0324
Journal article

The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity

Fielding, A. B., Concannon, M., Darling, S., Rusilowicz, E., Sacco, J., Prior, I. A., . . . Coulson, J. M. (2018). The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity. Oncogene, 37(17), 2326-2342. doi:10.1038/s41388-017-0092-0

DOI
10.1038/s41388-017-0092-0
Journal article

2017

Fibroblast Growth Factor 2 lethally sensitizes cancer cells to stress-targeted therapeutic inhibitors

DOI
10.1101/227496
Preprint

Regulation of the cell cycle and centrosome biology by deubiquitylases

Darling, S., Fielding, A. B., Sabat-Pospiech, D., Prior, I. A., & Coulson, J. M. (2017). Regulation of the cell cycle and centrosome biology by deubiquitylases. BIOCHEMICAL SOCIETY TRANSACTIONS, 45, 1125-1136. doi:10.1042/BST20170087

DOI
10.1042/BST20170087
Journal article

Abstract 179: Plasma membrane lipid therapy: disruption of oncogenic Ras spatiotemporal organization by membrane-targeted dietary bioactives (MTDB)

Fuentes, N. R., Barhoumi, R., Mlih, M., Karpac, J., Hardin, P., Steele, T., . . . Chapkin, R. S. (2017). Abstract 179: Plasma membrane lipid therapy: disruption of oncogenic Ras spatiotemporal organization by membrane-targeted dietary bioactives (MTDB). Cancer Research, 77(13_Supplement), 179. doi:10.1158/1538-7445.am2017-179

DOI
10.1158/1538-7445.am2017-179
Journal article

Serial block-face scanning electron microscopy applied to study the trafficking of 8D3-coated gold nanoparticles at the blood-brain barrier

Cabezón, I., Augé, E., Bosch, M., Beckett, A. J., Prior, I. A., Pelegrí, C., & Vilaplana, J. (2017). Serial block-face scanning electron microscopy applied to study the trafficking of 8D3-coated gold nanoparticles at the blood-brain barrier. Histochemistry and cell biology, 148(01), 3-12. doi:10.1007/s00418-017-1553-9

DOI
10.1007/s00418-017-1553-9
Journal article

Conserved effects and altered trafficking of Cetuximab antibodies conjugated to gold nanoparticles with precise control of their number and orientation

García-Fernández, L., Garcia-Pardo, J., Tort, O., Prior, I., Brust, M., Casals, E., . . . Puntes, V. F. (2017). Conserved effects and altered trafficking of Cetuximab antibodies conjugated to gold nanoparticles with precise control of their number and orientation. NANOSCALE, 9(18), 6111-6121. doi:10.1039/c7nr00947j

DOI
10.1039/c7nr00947j
Journal article

2016

The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z‐α1‐antitrypsin

Dickens, J. A., Ordóñez, A., Chambers, J. E., Beckett, A. J., Patel, V., Malzer, E., . . . Marciniak, S. J. (2016). The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z‐α1‐antitrypsin. The FASEB Journal, 30(12), 4083-4097. doi:10.1096/fj.201600430R

DOI
10.1096/fj.201600430R
Journal article

Microtubule organization within mitotic spindles revealed by serial block face scanning EM and image analysis

DOI
10.1101/087866
Preprint

Feedback activation of neurofibromin terminates growth factor-induced Ras activation

Hennig, A., Markwart, R., Wolff, K., Schubert, K., Cui, Y., Prior, I. A., . . . Rubio, I. (2016). Feedback activation of neurofibromin terminates growth factor-induced Ras activation. CELL COMMUNICATION AND SIGNALING, 14, 14 pages. doi:10.1186/s12964-016-0128-z

DOI
10.1186/s12964-016-0128-z
Journal article

2015

Comparative proteomic analysis of compartmentalised Ras signalling

Hernandez-Valladares, M., & Prior, I. A. (2015). Comparative proteomic analysis of compartmentalised Ras signalling. SCIENTIFIC REPORTS, 5. doi:10.1038/srep17307

DOI
10.1038/srep17307
Journal article

Absolute Quantification of Endogenous Ras Isoform Abundance

Mageean, C. J., Griffiths, J. R., Smith, D. L., Clague, M. J., & Prior, I. A. (2015). Absolute Quantification of Endogenous Ras Isoform Abundance. PLOS ONE, 10(11). doi:10.1371/journal.pone.0142674

DOI
10.1371/journal.pone.0142674
Journal article

The role of Ca2+influx in endocytic vacuole formation in pancreatic acinar cells

Voronina, S., Collier, D., Chvanov, M., Middlehurst, B., Beckett, A., Prior, I., . . . Tepikin, A. V. (2015). The role of Ca2+influx in endocytic vacuole formation in pancreatic acinar cells. Biochemical Journal, 465(3), 405-412. doi:10.1042/BJ20140398

DOI
10.1042/BJ20140398
Journal article

Electron Microscopy Methods for Studying Plasma Membranes

Beckett, A. J., & Prior, I. A. (2015). Electron Microscopy Methods for Studying Plasma Membranes. METHODS IN MEMBRANE LIPIDS, SECOND EDITION, 1232, 137-151. doi:10.1007/978-1-4939-1752-5_12

DOI
10.1007/978-1-4939-1752-5_12
Journal article

2014

Differential network reprogramming by distinct activating K-Ras mutations

Hammond, D. E., Mageean, C. J., Rusilowicz, E. V., Clague, M. J., & Prior, I. A. (2014). Differential network reprogramming by distinct activating K-Ras mutations. In MOLECULAR CANCER RESEARCH Vol. 12. doi:10.1158/1557-3125.RASONC14-B30

DOI
10.1158/1557-3125.RASONC14-B30
Conference Paper

Tissue- and isoform-specific Ras expression during development

Newlaczyl, A. U., Coulson, J. M., & Prior, I. A. (2014). Tissue- and isoform-specific Ras expression during development. In CANCER RESEARCH Vol. 74. doi:10.1158/1538-7445.AM2014-4449

DOI
10.1158/1538-7445.AM2014-4449
Conference Paper

Molecular dynamics modelling of local 3D structural differences in genes when carcinogens are bound at mutation hotspots – The link between structural change and mutation hotspot status

Menzies, G., Brancale, A., Prior, I., & Lewis, P. (2014). Molecular dynamics modelling of local 3D structural differences in genes when carcinogens are bound at mutation hotspots – The link between structural change and mutation hotspot status. Toxicology Letters, 229, S163. doi:10.1016/j.toxlet.2014.06.560

DOI
10.1016/j.toxlet.2014.06.560
Journal article

The neuroendocrine phenotype of gastric myofibroblasts and its loss with cancer progression

Balabanova, S., Holmberg, C., Steele, I., Ebrahimi, B., Rainbow, L., Burdyga, T., . . . Varro, A. (2014). The neuroendocrine phenotype of gastric myofibroblasts and its loss with cancer progression. Carcinogenesis, 35(8), 1798-1806. doi:10.1093/carcin/bgu086

DOI
10.1093/carcin/bgu086
Journal article

The neuroendocrine phenotype of gastric myofibroblasts and its loss with cancer progression

Balabanova, S., Holmberg, C., Steele, I., Ebrahimi, B., Rainbow, L., Burdyga, T., . . . Varro, A. (2014). The neuroendocrine phenotype of gastric myofibroblasts and its loss with cancer progression. Carcinogenesis, 35(8), 1798-1806. doi:10.1093/carcin/bgu086

DOI
10.1093/carcin/bgu086
Journal article

IDENTIFICATION OF CONCENTRIC LAMELLAE IN THE ARTICULAR CALCIFIED CARTILAGE OF OSTEOARTHRITIC MICE

Keenan, C. M., Beckett, A., Sutherland, H., Prior, I., Ranganath, L. R., Jarvis, J. C., & Gallagher, J. A. (2014). IDENTIFICATION OF CONCENTRIC LAMELLAE IN THE ARTICULAR CALCIFIED CARTILAGE OF OSTEOARTHRITIC MICE. In OSTEOARTHRITIS AND CARTILAGE Vol. 22 (pp. S363-S364). doi:10.1016/j.joca.2014.02.673

DOI
10.1016/j.joca.2014.02.673
Conference Paper

Decoding RAS isoform and codon-specific signalling

Newlaczyl, A. U., Hood, F. E., Coulson, J. M., & Prior, I. A. (2014). Decoding RAS isoform and codon-specific signalling. Biochem. Soc. Trans., 4, 7426.

Journal article

Quantitative Proteomic Analysis of Compartmentalized Signaling Networks

Hernandez-Valladares, M., Aran, V., & Prior, I. A. (2014). Quantitative Proteomic Analysis of Compartmentalized Signaling Networks. ENDOSOME SIGNALING, PT B, 535, 309-325. doi:10.1016/B978-0-12-397925-4.00018-3

DOI
10.1016/B978-0-12-397925-4.00018-3
Journal article

2013

Pronounced in vivo hemoglobin polymerization in red blood cells of Gulf toadfish: a general role for hemoglobin aggregation in vertebrate hemoparasite defense?

Koldkjaer, P., McDonald, M. D., Prior, I., & Berenbrink, M. (2013). Pronounced in vivo hemoglobin polymerization in red blood cells of Gulf toadfish: a general role for hemoglobin aggregation in vertebrate hemoparasite defense?. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 305(10), R1190-R1199. doi:10.1152/ajpregu.00246.2013

DOI
10.1152/ajpregu.00246.2013
Journal article

Oncogenic K-ras segregates at spatially distinct plasma membrane signaling platforms according to its phosphorylation status

Barcelo, C., Paco, N., Beckett, A. J., Alvarez-Moya, B., Garrido, E., Gelabert, M., . . . Agell, N. (2013). Oncogenic K-ras segregates at spatially distinct plasma membrane signaling platforms according to its phosphorylation status. JOURNAL OF CELL SCIENCE, 126(20), 4553-4559. doi:10.1242/jcs.123737

DOI
10.1242/jcs.123737
Journal article

Ras palmitoylation is necessary for N-Ras activation and signal propagation in growth factor signalling

Song, S. -P., Hennig, A., Schubert, K., Markwart, R., Schmidt, P., Prior, I. A., . . . Rubio, I. (2013). Ras palmitoylation is necessary for N-Ras activation and signal propagation in growth factor signalling. Biochemical Journal, 455(1), 131. doi:10.1042/bj4550131v

DOI
10.1042/bj4550131v
Journal article

Compartmentalized Ras signaling differentially contributes to phenotypic outputs

Aran, V., & Prior, I. A. (2013). Compartmentalized Ras signaling differentially contributes to phenotypic outputs. CELLULAR SIGNALLING, 25(9), 1748-1753. doi:10.1016/j.cellsig.2013.05.004

DOI
10.1016/j.cellsig.2013.05.004
Journal article

Ras palmitoylation is necessary for N-Ras activation and signal propagation in growth factor signalling

Song, S. -P., Hennig, A., Schubert, K., Markwart, R., Schmidt, P., Prior, I. A., . . . Rubio, I. (2013). Ras palmitoylation is necessary for N-Ras activation and signal propagation in growth factor signalling. BIOCHEMICAL JOURNAL, 454, 323-332. doi:10.1042/BJ20121799

DOI
10.1042/BJ20121799
Journal article

Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension

Cheeseman, L. P., Harry, E. F., McAinsh, A. D., Prior, I. A., & Royle, S. J. (2013). Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension. JOURNAL OF CELL SCIENCE, 126(9), 2102-2113. doi:10.1242/jcs.124834

DOI
10.1242/jcs.124834
Journal article

CD317/tetherin is an organiser of membrane microdomains

Billcliff, P. G., Rollason, R., Prior, I., Owen, D. M., Gaus, K., & Banting, G. (2013). CD317/tetherin is an organiser of membrane microdomains. JOURNAL OF CELL SCIENCE, 126(7), 1553-1564. doi:10.1242/jcs.112953

DOI
10.1242/jcs.112953
Journal article

The role of palmitoylation in regulating Ras localization and function

Eisenberg, S., Laude, A. J., Beckett, A. J., Mageean, C. J., Aran, V., Hernandez-Valladares, M., . . . Prior, I. A. (2013). The role of palmitoylation in regulating Ras localization and function. BIOCHEMICAL SOCIETY TRANSACTIONS, 41, 79-83. doi:10.1042/BST20120268

DOI
10.1042/BST20120268
Journal article

Plasticity of mammary cell boundaries governed by EGF

Tang, Y., Beckett, A. J., Prior, I. A., Coulson, J. M., Urbe, S., & Clague, M. J. (2013). Plasticity of mammary cell boundaries governed by EGF. MOLECULAR BIOLOGY OF THE CELL, 24. Retrieved from https://www.webofscience.com/

Journal article

Studying Kinetochore-Fiber Ultrastructure Using Correlative Light-Electron Microscopy

Booth, D. G., Cheeseman, L. P., Prior, I. A., & Royle, S. J. (2013). Studying Kinetochore-Fiber Ultrastructure Using Correlative Light-Electron Microscopy. MICROTUBULES, IN VITRO, 2ND EDITION, 115, 327-342. doi:10.1016/B978-0-12-407757-7.00020-7

DOI
10.1016/B978-0-12-407757-7.00020-7
Journal article

2012

Global Snapshot of the Influence of Endocytosis upon EGF Receptor Signaling Output

Omerovic, J., Hammond, D. E., Prior, I. A., & Clague, M. J. (2012). Global Snapshot of the Influence of Endocytosis upon EGF Receptor Signaling Output. Journal of Proteome Research, 11(11), 5157-5166. doi:10.1021/pr3007304

DOI
10.1021/pr3007304
Journal article

Global Snapshot of the Influence of Endocytosis upon EGF Receptor Signaling Output

Omerovic, J., Hammond, D. E., Prior, I. A., & Clague, M. J. (2012). Global Snapshot of the Influence of Endocytosis upon EGF Receptor Signaling Output. JOURNAL OF PROTEOME RESEARCH, 11(11), 5157-5166. doi:10.1021/pr3007304

DOI
10.1021/pr3007304
Journal article

Transport of Fibroblast Growth Factor 2 in the Pericellular Matrix Is Controlled by the Spatial Distribution of Its Binding Sites in Heparan Sulfate

Duchesne, L., Octeau, V., Bearon, R. N., Beckett, A., Prior, I. A., Lounis, B., & Fernig, D. G. (2012). Transport of Fibroblast Growth Factor 2 in the Pericellular Matrix Is Controlled by the Spatial Distribution of Its Binding Sites in Heparan Sulfate. PLOS BIOLOGY, 10(7). doi:10.1371/journal.pbio.1001361

DOI
10.1371/journal.pbio.1001361
Journal article

A Comprehensive Survey of Ras Mutations in Cancer

Prior, I. A., Lewis, P. D., & Mattos, C. (2012). A Comprehensive Survey of Ras Mutations in Cancer. CANCER RESEARCH, 72(10), 2457-2467. doi:10.1158/0008-5472.CAN-11-2612

DOI
10.1158/0008-5472.CAN-11-2612
Journal article

Mercaptocarborane-Capped Gold Nanoparticles: Electron Pools and Ion Traps with Switchable Hydrophilicity

Cioran, A. M., Musteti, A. D., Teixidor, F., Krpetic, Z., Prior, I. A., He, Q., . . . Vinas, C. (2012). Mercaptocarborane-Capped Gold Nanoparticles: Electron Pools and Ion Traps with Switchable Hydrophilicity. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134(1), 212-221. doi:10.1021/ja203367h

DOI
10.1021/ja203367h
Journal article

Putting signalling into context

Prior, I. A. (2012). Putting signalling into context. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 23(2), 125. doi:10.1016/j.semcdb.2012.02.008

DOI
10.1016/j.semcdb.2012.02.008
Journal article

Quantitative FRAP Analysis Demonstrates that Raft Protein Clustering Alters N-Ras Depalmitoylation, Membrane Interactions and Activation Pattern

Eisenberg, S., Wolfenson, H., Berkovich, R., Prior, I. A., Ehrlich, M., Klafter, J., . . . Henis, Y. I. (2012). Quantitative FRAP Analysis Demonstrates that Raft Protein Clustering Alters N-Ras Depalmitoylation, Membrane Interactions and Activation Pattern. Biophysical Journal, 102(3), 32a. doi:10.1016/j.bpj.2011.11.201

DOI
10.1016/j.bpj.2011.11.201
Journal article

Ras trafficking, localization and compartmentalized signalling

Prior, I. A., & Hancock, J. F. (2012). Ras trafficking, localization and compartmentalized signalling. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 23(2), 145-153. doi:10.1016/j.semcdb.2011.09.002

DOI
10.1016/j.semcdb.2011.09.002
Journal article

2011

Raft Protein Clustering Alters N-Ras Membrane Interactions and Activation Pattern

Eisenberg, S., Beckett, A. J., Prior, I. A., Dekker, F. J., Hedberg, C., Waldmann, H., . . . Henis, Y. I. (2011). Raft Protein Clustering Alters N-Ras Membrane Interactions and Activation Pattern. MOLECULAR AND CELLULAR BIOLOGY, 31(19), 3938-3952. doi:10.1128/MCB.05570-11

DOI
10.1128/MCB.05570-11
Journal article

Intracellular mapping with SERS-encoded gold nanostars

Rodriguez-Lorenzo, L., Krpetic, Z., Barbosa, S., Alvarez-Puebla, R. A., Liz-Marzan, L. M., Prior, I. A., & Brust, M. (2011). Intracellular mapping with SERS-encoded gold nanostars. INTEGRATIVE BIOLOGY, 3(9), 922-926. doi:10.1039/c1ib00029b

DOI
10.1039/c1ib00029b
Journal article

Acrylate-Facilitated Cellular Uptake of Gold Nanoparticles

Krpetic, Z., Nativo, P., Prior, I. A., & Brust, M. (2011). Acrylate-Facilitated Cellular Uptake of Gold Nanoparticles. SMALL, 7(14), 1982-1986. doi:10.1002/smll.201100462

DOI
10.1002/smll.201100462
Journal article

Aurora A kinase activity is required for localization of TACC3/ch-TOG/clathrin inter-microtubule bridges

Cheeseman, L. P., Booth, D. G., Hood, F. E., Prior, I. A., & Royle, S. J. (2011). Aurora A kinase activity is required for localization of TACC3/ch-TOG/clathrin inter-microtubule bridges. Communicative & Integrative Biology, 4(4), 409-412. doi:10.4161/cib.15250

DOI
10.4161/cib.15250
Journal article

Negotiation of Intracellular Membrane Barriers by TAT-Modified Gold Nanoparticles

Krpetic, Z., Saleemi, S., Prior, I. A., See, V., Qureshi, R., & Brust, M. (2011). Negotiation of Intracellular Membrane Barriers by TAT-Modified Gold Nanoparticles. ACS NANO, 5(6), 5195-5201. doi:10.1021/nn201369k

DOI
10.1021/nn201369k
Journal article

A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging

Booth, D. G., Hood, F. E., Prior, I. A., & Royle, S. J. (2011). A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging. EMBO JOURNAL, 30(5), 906-919. doi:10.1038/emboj.2011.15

DOI
10.1038/emboj.2011.15
Journal article

Magnetic CoPt nanoparticles as MRI contrast agent for transplanted neural stem cells detection

Meng, X., Seton, H. C., Lu, L. T., Prior, I. A., Thanh, N. T. K., & Song, B. (2011). Magnetic CoPt nanoparticles as MRI contrast agent for transplanted neural stem cells detection. NANOSCALE, 3(3), 977-984. doi:10.1039/c0nr00846j

DOI
10.1039/c0nr00846j
Journal article

2010

Highly Stable Dextran-Coated Quantum Dots for Biomolecular Detection and Cellular Imaging

Wilson, R., Spiller, D. G., Beckett, A., Prior, I. A., & See, V. (2010). Highly Stable Dextran-Coated Quantum Dots for Biomolecular Detection and Cellular Imaging. CHEMISTRY OF MATERIALS, 22(23), 6361-6369. doi:10.1021/cm1023635

DOI
10.1021/cm1023635
Journal article

Inflicting Controlled Nonthermal Damage to Subcellular Structures by Laser-Activated Gold Nanoparticles

Krpetić, Ž., Nativo, P., Sée, V., Prior, I. A., Brust, M., & Volk, M. (2010). Inflicting Controlled Nonthermal Damage to Subcellular Structures by Laser-Activated Gold Nanoparticles. Nano Letters, 10(11), 4549-4554. doi:10.1021/nl103142t

DOI
10.1021/nl103142t
Journal article

Inflicting Controlled Nonthermal Damage to Subcellular Structures by Laser-Activated Gold Nanoparticles

Krpetic, Z., Nativo, P., See, V., Prior, I. A., Brust, M., & Volk, M. (2010). Inflicting Controlled Nonthermal Damage to Subcellular Structures by Laser-Activated Gold Nanoparticles. NANO LETTERS, 10(11), 4549-4554. doi:10.1021/nl103142t

DOI
10.1021/nl103142t
Journal article

Regulatory activity of polyunsaturated fatty acids in T-cell signaling

Kim, W., Khan, N. A., McMurray, D. N., Prior, I. A., Wang, N., & Chapkin, R. S. (2010). Regulatory activity of polyunsaturated fatty acids in T-cell signaling. PROGRESS IN LIPID RESEARCH, 49(3), 250-261. doi:10.1016/j.plipres.2010.01.002

DOI
10.1016/j.plipres.2010.01.002
Journal article

Ultrastructural examination of tissue in a patient with alkaptonuric arthropathy reveals a distinct pattern of binding of ochronotic pigment

Taylor, A. M., Wlodarski, B., Prior, I. A., Wilson, P. J. M., Jarvis, J. C., Ranganath, L. R., & Gallagher, J. A. (2010). Ultrastructural examination of tissue in a patient with alkaptonuric arthropathy reveals a distinct pattern of binding of ochronotic pigment. Rheumatology, 49(7), 1412-1414. doi:10.1093/rheumatology/keq027

DOI
10.1093/rheumatology/keq027
Journal article

Ultrastructural examination of tissue in a patient with alkaptonuric arthropathy reveals a distinct pattern of binding of ochronotic pigment

Taylor, A. M., Wlodarski, B., Prior, I. A., Wilson, P. J. M., Jarvis, J. C., Ranganath, L. R., & Gallagher, J. A. (2010). Ultrastructural examination of tissue in a patient with alkaptonuric arthropathy reveals a distinct pattern of binding of ochronotic pigment. RHEUMATOLOGY, 49(7), 1412-1414. doi:10.1093/rheumatology/keq027

DOI
10.1093/rheumatology/keq027
Journal article

Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells

Omerovic, J., Clague, M. J., & Prior, I. A. (2010). Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells. BIOCHEMICAL JOURNAL, 426, 65-72. doi:10.1042/BJ20091413

DOI
10.1042/BJ20091413
Journal article

Intracellular Delivery and Fate of Peptide-Capped Gold Nanoparticles

Cesbron, Y., See, V., Free, P., Nativo, P., Shaheen, U., Rigden, D. J., . . . Levy, R. (2010). Intracellular Delivery and Fate of Peptide-Capped Gold Nanoparticles. In BIOPHYSICAL JOURNAL Vol. 98 (pp. 203A). doi:10.1016/j.bpj.2009.12.1081

DOI
10.1016/j.bpj.2009.12.1081
Conference Paper

Laser-induced Delivery of Gold Nanoparticles into Living Cells

Nativo, P., Brust, M., See, V., Prior, I., & Volk, M. (2010). Laser-induced Delivery of Gold Nanoparticles into Living Cells. In B. Wyborn (Ed.), Central Laser Facility Annual Report 2008/09 (pp. 190-192). Didcot: Science and Technology Facilities Council.

Chapter

2009

Ribosome-free Terminals of Rough ER Allow Formation of STIM1 Puncta and Segregation of STIM1 from IP<sub>3</sub> Receptors

Lur, G., Haynes, L. P., Prior, I. A., Gerasimenko, O. V., Feske, S., Petersen, O. H., . . . Tepikin, A. V. (2009). Ribosome-free Terminals of Rough ER Allow Formation of STIM1 Puncta and Segregation of STIM1 from IP<sub>3</sub> Receptors. CURRENT BIOLOGY, 19(19), 1648-1653. doi:10.1016/j.cub.2009.07.072

DOI
10.1016/j.cub.2009.07.072
Journal article

Cathepsin L Digestion of Nanobioconjugates upon Endocytosis

See, V., Free, P., Cesbron, Y., Nativo, P., Shaheen, U., Rigden, D. J., . . . Levy, R. (2009). Cathepsin L Digestion of Nanobioconjugates upon Endocytosis. ACS NANO, 3(9), 2461-2468. doi:10.1021/nn9006994

DOI
10.1021/nn9006994
Journal article

Variant shape growth of nanoparticles of metallic Fe-Pt, Fe-Pd and Fe-Pt-Pd alloys

Ung, D., Tung, L. D., Caruntu, G., Delaportas, D., Alexandrou, I., Prior, I. A., & Thanh, N. T. K. (2009). Variant shape growth of nanoparticles of metallic Fe-Pt, Fe-Pd and Fe-Pt-Pd alloys. CRYSTENGCOMM, 11(7), 1309-1316. doi:10.1039/b823290n

DOI
10.1039/b823290n
Journal article

A reliable method for attaching biological molecules to layer-by-layer self-assemblies

Wilson, R., Mehrabi, M., Prior, I. A., Beckett, A., & Hutchinson, A. (2009). A reliable method for attaching biological molecules to layer-by-layer self-assemblies. CHEMICAL COMMUNICATIONS, (18), 2487-2489. doi:10.1039/b822688a

DOI
10.1039/b822688a
Journal article

Connexin expression and gap junctional coupling in human cumulus cells: contribution to embryo quality

Wang, H. -X., Tong, D., El-Gehani, F., Tekpetey, F. R., & Kidder, G. M. (2009). Connexin expression and gap junctional coupling in human cumulus cells: contribution to embryo quality. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 13(5), 972-984. doi:10.1111/j.1582-4934.2008.00373.x

DOI
10.1111/j.1582-4934.2008.00373.x
Journal article

Three-dimensional electron microscopic reconstruction of intracellular organellar arrangements in vascular smooth muscle--further evidence of nanospaces and contacts.

Tong, W. C., Sweeney, M., Jones, C. J. P., Zhang, H., O'Neill, S. C., Prior, I., & Taggart, M. J. (2009). Three-dimensional electron microscopic reconstruction of intracellular organellar arrangements in vascular smooth muscle--further evidence of nanospaces and contacts.. Journal of cellular and molecular medicine, 13(5), 995-998. doi:10.1111/j.1582-4934.2009.00770.x

DOI
10.1111/j.1582-4934.2009.00770.x
Journal article

Compartmentalized signalling: Ras proteins and signalling nanoclusters

Omerovic, J., & Prior, I. A. (2009). Compartmentalized signalling: Ras proteins and signalling nanoclusters. FEBS JOURNAL, 276(7), 1817-1825. doi:10.1111/j.1742-4658.2009.06928.x

DOI
10.1111/j.1742-4658.2009.06928.x
Journal article

Compartmentalized signalling: cAMP, calcium and Ras

Prior, I. A. (2009). Compartmentalized signalling: cAMP, calcium and Ras. FEBS JOURNAL, 276(7), 1789. doi:10.1111/j.1742-4658.2009.06925.x

DOI
10.1111/j.1742-4658.2009.06925.x
Journal article

Ras acylation, compartmentalization and signaling nanoclusters (Review)

Henis, Y. I., Hancock, J. F., & Prior, I. A. (2009). Ras acylation, compartmentalization and signaling nanoclusters (Review). MOLECULAR MEMBRANE BIOLOGY, 26(1-2), 80-92. doi:10.1080/09687680802649582

DOI
10.1080/09687680802649582
Journal article

Three-dimensional electron microscopic reconstruction of sarcoplasmic reticular arrangement in vascular smooth muscle with respect to mitochondria and the nucleus - further evidence of nanospaces and contacts

Tong, W. C., Sweeney, M., Jones, C. J. P., Zhang, H., O'Neill, S. C., Prior, I., & Taggart, M. J. (2009). Three-dimensional electron microscopic reconstruction of sarcoplasmic reticular arrangement in vascular smooth muscle with respect to mitochondria and the nucleus - further evidence of nanospaces and contacts. J. Cellular Mol. Med., in press.

Journal article

2008

Uptake and intracellular fate of surface-modified gold nanoparticles

Nativo, P., Prior, I. A., & Brust, M. (2008). Uptake and intracellular fate of surface-modified gold nanoparticles. ACS NANO, 2(8), 1639-1644. doi:10.1021/nn800330a

DOI
10.1021/nn800330a
Journal article

S-nitrosylation of syntaxin 1 at Cys<SUP>145</SUP> is a regulatory switch controlling Munc18-1 binding

Palmer, Z. J., Duncan, R. R., Johnson, J. R., Lian, L. -Y., Mello, L. V., Booth, D., . . . Morgan, A. (2008). S-nitrosylation of syntaxin 1 at Cys<SUP>145</SUP> is a regulatory switch controlling Munc18-1 binding. BIOCHEMICAL JOURNAL, 413, 479-491. doi:10.1042/BJ20080069

DOI
10.1042/BJ20080069
Journal article

Ras isoform abundance and signalling in human cancer cell lines

Omerovic, J., Hammond, D. E., Clague, M. J., & Prior, I. A. (2008). Ras isoform abundance and signalling in human cancer cell lines. ONCOGENE, 27(19), 2754-2762. doi:10.1038/sj.onc.1210925

DOI
10.1038/sj.onc.1210925
Journal article

Palmitoylation and localisation of RAS isoforms are modulated by the hypervariable linker domain

Laude, A. J., & Prior, I. A. (2008). Palmitoylation and localisation of RAS isoforms are modulated by the hypervariable linker domain. JOURNAL OF CELL SCIENCE, 121(4), 421-427. doi:10.1242/jcs.020107

DOI
10.1242/jcs.020107
Journal article

Docosahexaenoic acid alters the size and distribution of cell surface microdomains

Chapkin, R. S., Wang, N., Fan, Y. -Y., Lupton, J. R., & Prior, I. A. (2008). Docosahexaenoic acid alters the size and distribution of cell surface microdomains. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1778(2), 466-471. doi:10.1016/j.bbamem.2007.11.003

DOI
10.1016/j.bbamem.2007.11.003
Journal article

2007

The Vpu-regulated endocytosis of HIV-1 Gag is clathrin-independent

Harila, K., Salminen, A., Prior, I., Hinkula, J., & Suomalainen, M. (2007). The Vpu-regulated endocytosis of HIV-1 Gag is clathrin-independent. VIROLOGY, 369(2), 299-308. doi:10.1016/j.virol.2007.08.009

DOI
10.1016/j.virol.2007.08.009
Journal article

A simple method for preparing spectrally encoded magnetic beads for multiplexed detection

Wilson, R., Spiller, D. G., Prior, I. A., Veltkamp, K. J., & Hutchinson, A. (2007). A simple method for preparing spectrally encoded magnetic beads for multiplexed detection. ACS NANO, 1(5), 487-493. doi:10.1021/nn700289m

DOI
10.1021/nn700289m
Journal article

Magnetic microspheres encoded with photoluminescent quantum dots for multiplexed detection

Wilson, R., Spiller, D. G., Prior, I. A., Bhatt, R., & Hutchinson, A. (2007). Magnetic microspheres encoded with photoluminescent quantum dots for multiplexed detection. JOURNAL OF MATERIALS CHEMISTRY, 17(41), 4400-4406. doi:10.1039/b708174j

DOI
10.1039/b708174j
Journal article

Ras proteins: paradigms for compartmentalised and isoform-specific signalling

Omerovic, J., Laude, A. J., & Prior, I. A. (2007). Ras proteins: paradigms for compartmentalised and isoform-specific signalling. CELLULAR AND MOLECULAR LIFE SCIENCES, 64(19-20), 2575-2589. doi:10.1007/s00018-007-7133-8

DOI
10.1007/s00018-007-7133-8
Journal article

Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells

Sherwood, M. W., Prior, I. A., Voronina, S. G., Barrow, S. L., Woodsmith, J. D., Gerasimenko, O. V., . . . Tepikin, A. V. (2007). Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104(13), 5674-5679. doi:10.1073/pnas.0700951104

DOI
10.1073/pnas.0700951104
Journal article

2006

Control of growth factor receptor dynamics by reversible ubiquitination

Urbe, S., McCullough, J., Row, P. E., Prior, I. A., Welchman, R., & Clague, M. J. (2006). Control of growth factor receptor dynamics by reversible ubiquitination. BIOCHEMICAL SOCIETY TRANSACTIONS, 34, 754-756. doi:10.1042/BST0340754

DOI
10.1042/BST0340754
Journal article

The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation

Row, P. E., Prior, I. A., McCullough, J., Clague, M. J., & Urbé, S. (2006). The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(18), 12618-12624. doi:10.1074/jbc.M512615200

DOI
10.1074/jbc.M512615200
Journal article

Vpu and Tsg101 regulate intracellular targeting of the human immunodeficiency virus type 1 core protein precursor Pr55<i><SUP>gag</SUP></i>

Harila, K., Prior, I., Sjöberg, M., Salminen, A., Hinkula, J., & Suomalainen, M. (2006). Vpu and Tsg101 regulate intracellular targeting of the human immunodeficiency virus type 1 core protein precursor Pr55<i><SUP>gag</SUP></i>. JOURNAL OF VIROLOGY, 80(8), 3765-3772. doi:10.1128/JVI.80.8.3765-3772.2006

DOI
10.1128/JVI.80.8.3765-3772.2006
Journal article

2005

Traffic of Kv4 K<SUP>+</SUP> channels mediated by KChlP1 is via a novel post-ER vesicular pathway

Hasdemir, B., Fitzgerald, D. J., Prior, I. A., Tepikin, A. V., & Burgoyne, R. D. (2005). Traffic of Kv4 K<SUP>+</SUP> channels mediated by KChlP1 is via a novel post-ER vesicular pathway. JOURNAL OF CELL BIOLOGY, 171(3), 459-469. doi:10.1083/jcb.200506005

DOI
10.1083/jcb.200506005
Journal article

Electron microscopic imaging of Ras signaling domains

Hancock, J. F., & Prior, I. A. (2005). Electron microscopic imaging of Ras signaling domains. METHODS, 37(2), 165-172. doi:10.1016/j.ymeth.2005.05.018

DOI
10.1016/j.ymeth.2005.05.018
Journal article

Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling

Roy, S., Plowman, S., Rotblat, B., Prior, I. A., Muncke, C., Grainger, S., . . . Hancock, J. F. (2005). Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling. MOLECULAR AND CELLULAR BIOLOGY, 25(15), 6722-6733. doi:10.1128/MCB.25.15.6722-6733.2005

DOI
10.1128/MCB.25.15.6722-6733.2005
Journal article

2004

Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane

Rotblat, B., Prior, I. A., Muncke, C., Parton, R. G., Kloog, Y., Henis, Y. I., & Hancock, J. F. (2004). Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane. MOLECULAR AND CELLULAR BIOLOGY, 24(15), 6799-6810. doi:10.1128/MCB.24.15.6799-6810.2004

DOI
10.1128/MCB.24.15.6799-6810.2004
Journal article

Plasma membrane microdomains: organization, function and trafficking (Review)

Laude, A. J., & Prior, I. A. (2004). Plasma membrane microdomains: organization, function and trafficking (Review). MOLECULAR MEMBRANE BIOLOGY, 21(3), 193-205. doi:10.1080/09687680410001700517

DOI
10.1080/09687680410001700517
Journal article

2003

C-terminal sequences in R-Ras are involved in integrin regulation and in plasma membrane microdomain distribution

Hansen, M., Prior, I. A., Hughes, P. E., Oertli, B., Chou, F. L., Willumsen, B. M., . . . Ginsberg, M. H. (2003). C-terminal sequences in R-Ras are involved in integrin regulation and in plasma membrane microdomain distribution. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 311(4), 829-838. doi:10.1016/j.bbrc.2003.10.074

DOI
10.1016/j.bbrc.2003.10.074
Journal article

Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane

Wyse, B. D., Prior, I. A., Qian, H. W., Morrow, I. C., Nixon, S., Muncke, C., . . . Hancock, J. F. (2003). Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane. JOURNAL OF BIOLOGICAL CHEMISTRY, 278(26), 23738-23746. doi:10.1074/jbc.M212892200

DOI
10.1074/jbc.M212892200
Journal article

Observing cell surface signaling domains using electron microscopy.

Prior, I. A., Parton, R. G., & Hancock, J. F. (2003). Observing cell surface signaling domains using electron microscopy.. Science's STKE : signal transduction knowledge environment, 2003(177), PL9. doi:10.1126/stke.2003.177.pl9

DOI
10.1126/stke.2003.177.pl9
Journal article

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

Prior, I. A., Muncke, C., Parton, R. G., & Hancock, J. F. (2003). Direct visualization of Ras proteins in spatially distinct cell surface microdomains. JOURNAL OF CELL BIOLOGY, 160(2), 165-170. doi:10.1083/jcb.200209091

DOI
10.1083/jcb.200209091
Journal article

2002

Flotillin-1/Reggie-2 traffics to surface raft domains via a novel Golgi-independent pathway - Identification of a novel membrane targeting domain and a role for palmitoylation

Morrow, I. C., Rea, S., Martin, S., Prior, I. A., Prohaska, R., Hancock, J. F., . . . Parton, R. G. (2002). Flotillin-1/Reggie-2 traffics to surface raft domains via a novel Golgi-independent pathway - Identification of a novel membrane targeting domain and a role for palmitoylation. JOURNAL OF BIOLOGICAL CHEMISTRY, 277(50), 48834-48841. doi:10.1074/jbc.M209082200

DOI
10.1074/jbc.M209082200
Journal article

Inhibition of lipid raft-dependent signaling by a dystrophy-associated mutant of caveolin-3

Carozzi, A. J., Roy, S., Morrow, I. C., Pol, A., Wyse, B., Clyde-Smith, J., . . . Parton, R. G. (2002). Inhibition of lipid raft-dependent signaling by a dystrophy-associated mutant of caveolin-3. JOURNAL OF BIOLOGICAL CHEMISTRY, 277(20), 17944-17949. doi:10.1074/jbc.M110879200

DOI
10.1074/jbc.M110879200
Journal article

2001

Compartmentalization of Ras proteins.

Prior, I. A., & Hancock, J. F. (2001). Compartmentalization of Ras proteins.. Journal of cell science, 114(Pt 9), 1603-1608. doi:10.1242/jcs.114.9.1603

DOI
10.1242/jcs.114.9.1603
Journal article

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

Prior, I. A., Harding, A., Yan, J., Sluimer, J., Parton, R. G., & Hancock, J. F. (2001). GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. NATURE CELL BIOLOGY, 3(4), 368-375. doi:10.1038/35070050

DOI
10.1038/35070050
Journal article

Compartmentalization of Ras proteins

Prior, I. A., & Hancock, J. F. (2001). Compartmentalization of Ras proteins. J Cell Sci, 114(Pt 9), 1603-1608. Retrieved from http://www.ncbi.nlm.nih.gov/

Journal article

Compartmentalization of Ras proteins

Prior, I. A., & Hancock, J. F. (2001). Compartmentalization of Ras proteins. JOURNAL OF CELL SCIENCE, 114(9), 1603-1608. Retrieved from https://www.webofscience.com/

Journal article

Which Ras rides the raft? Reply

Prior, I. A., Parton, R. G., & Hancock, J. F. (2001). Which Ras rides the raft? Reply. NATURE CELL BIOLOGY, 3(8), E172. doi:10.1038/35087100

DOI
10.1038/35087100
Journal article

2000

Detection of thiol modification following generation of reactive nitrogen species: analysis of synaptic vesicle proteins

Prior, I. A., & Clague, M. J. (2000). Detection of thiol modification following generation of reactive nitrogen species: analysis of synaptic vesicle proteins. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1475(3), 281-286. doi:10.1016/S0304-4165(00)00078-7

DOI
10.1016/S0304-4165(00)00078-7
Journal article

H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

Apolloni, A., Prior, I. A., Lindsay, M., Parton, R. G., & Hancock, J. F. (2000). H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway. MOLECULAR AND CELLULAR BIOLOGY, 20(7), 2475-2487. doi:10.1128/MCB.20.7.2475-2487.2000

DOI
10.1128/MCB.20.7.2475-2487.2000
Journal article

1999

Localization of a class II phosphatidylinositol 3-kinase, PI3KC2alpha, to clathrin-coated vesicles.

Prior, I. A., & Clague, M. J. (1999). Localization of a class II phosphatidylinositol 3-kinase, PI3KC2alpha, to clathrin-coated vesicles.. Molecular cell biology research communications : MCBRC, 1(2), 162-166. doi:10.1006/mcbr.1999.0126

DOI
10.1006/mcbr.1999.0126
Journal article

1998

Evaluation of X-ray microfluorescence spectrometry for the elemental analysis of firearm discharge residues

Flynn, J., Stoilovic, M., Lennard, C., Prior, L., & Kobus, H. (1998). Evaluation of X-ray microfluorescence spectrometry for the elemental analysis of firearm discharge residues. FORENSIC SCIENCE INTERNATIONAL, 97(1), 21-36. doi:10.1016/S0379-0738(98)00127-3

DOI
10.1016/S0379-0738(98)00127-3
Journal article

1997

Glutamate uptake occurs at an early stage of synaptic vesicle recycling

Prior, I. A., & Clague, M. J. (1997). Glutamate uptake occurs at an early stage of synaptic vesicle recycling. CURRENT BIOLOGY, 7(5), 353-356. doi:10.1016/S0960-9822(06)00159-X

DOI
10.1016/S0960-9822(06)00159-X
Journal article