Publications
Selected publications
- The small molecule inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release (Preprint - 2023)
- Metabolic Profiling of Rheumatoid Arthritis Neutrophils Reveals Altered Energy Metabolism That Is Not Affected by JAK Inhibition (Journal article - 2022)
- Rheumatoid Arthritis Synovial Fluid Neutrophils Drive Inflammation Through Production of Chemokines, Reactive Oxygen Species, and Neutrophil Extracellular Traps (Journal article - 2021)
- Caught in a Trap? Proteomic analysis of neutrophil extracellular traps in rheumatoid arthritis and systemic lupus erythematosus (Journal article - 2019)
- The multifactorial role of neutrophils in rheumatoid arthritis (Journal article - 2014)
- LAT1 enables T cell activation under inflammatory conditions (Journal article - 2023)
- miRNA-132-5p mediates a negative feedback regulation of IL-8 secretion through S100A8/A9 downregulation in neutrophil-like HL-60 cells (Journal article - 2023)
- Neutrophils in the Pathogenesis of Rheumatoid Arthritis and Systemic Lupus Erythematosus: Same Foe Different MO (Journal article - 2021)
- Circulating Neutrophil Extracellular Trap (NET)-forming neutrophils in rheumatoid arthritis exacerbation are majority dual endothelin-1/signal peptide receptor (DEspR)+ subtype (Journal article - 2024)
- New Insights into Healthy Ageing, Inflammageing and Frailty using Metabolomics (Journal article - 2024)
2024
Circulating Neutrophil Extracellular Trap (NET)-forming neutrophils in rheumatoid arthritis exacerbation are majority dual endothelin-1/signal peptide receptor (DEspR)+ subtype
Cross, A., Wright, H., Choi, J., Edwards, S., Ruiz-Opazo, N., & Herrera, H. (n.d.). Circulating Neutrophil Extracellular Trap (NET)-forming neutrophils in rheumatoid arthritis exacerbation are majority dual endothelin-1/signal peptide receptor (DEspR)+ subtype. Clinical and Experimental Immunology.
Serum metabolomics identifies unique inflammatory signatures to distinguish rheumatoid arthritis responders and non-responders to TNF inhibitor therapy
New Insights into Healthy Ageing, Inflammageing and Frailty using Metabolomics
Abdullah, G., Akpan, A., Phelan, M., & Wright, H. (2024). New Insights into Healthy Ageing, Inflammageing and Frailty using Metabolomics. Frontiers in Aging.
Platelet TLR7 is essential for the formation of platelet-neutrophil complexes and low-density neutrophils in lupus nephritis
Tay, S. H., Zharkova, O., Lee, H. Y., Toh, M. M. X., Libau, E. A., Celhar, T., . . . Fairhurst, A. -M. (2023). Platelet TLR7 is essential for the formation of platelet-neutrophil complexes and low-density neutrophils in lupus nephritis. RHEUMATOLOGY. doi:10.1093/rheumatology/kead296
2023
The small molecule inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Regulation of Dermal Fibroblasts by Human Neutrophil Peptides
Niwetbowornchai, N., Chaisirirat, T., Sriswasdi, S., Saithong, S., Filbertine, G., Wright, H., . . . Chiewchengchol, D. (2023). Regulation of Dermal Fibroblasts by Human Neutrophil Peptides. Scientific Reports.
LAT1 enables T cell activation under inflammatory conditions
Ogbechi, J., Wright, H., Balint, S., Topping, L., Zec, K., Huang, Y. -S., . . . Williams, R. (2023). LAT1 enables T cell activation under inflammatory conditions. Journal of Autoimmunity. doi:10.1016/j.jaut.2023.103031
Neutrophil function following treatment of psoriatic arthritis patients with secukinumab: altered cytokine signalling but no impairment of host defence
Cross, A., Hawkes, J., Frankland, H., Mediana, A., Wright, H., Goodson, N., . . . Moots, R. (2023). Neutrophil function following treatment of psoriatic arthritis patients with secukinumab: altered cytokine signalling but no impairment of host defence. Rheumatology. doi:10.1093/rheumatology/kead007
miRNA-132-5p mediates a negative feedback regulation of IL-8 secretion through S100A8/A9 downregulation in neutrophil-like HL-60 cells
Zhou, Y., Nomigni, M. T., Gaigneaux, A., Tolle, F., Wright, H. L., Bueb, J. -L., & Bréchard, S. (n.d.). miRNA-132-5p mediates a negative feedback regulation of IL-8 secretion through S100A8/A9 downregulation in neutrophil-like HL-60 cells. Frontiers in Immunology, 14. doi:10.3389/fimmu.2023.1274378
2022
Markers of immune dysregulation in response to the ageing gut: insights from aged murine gut microbiota transplants
Giannos, P., Prokopidis, K., Isanejad, M., & Wright, H. L. (2022). Markers of immune dysregulation in response to the ageing gut: insights from aged murine gut microbiota transplants. BMC GASTROENTEROLOGY, 22(1). doi:10.1186/s12876-022-02613-2
LAT1 enables T cell activation under inflammatory conditions: a new therapeutic target for rheumatoid arthritis
Bi-allelic FRA10AC1 variants in a multisystem human syndrome
Banka, S., Shalev, S., Park, S. -M., Wood, K., Thomas, H., Wright, H., . . . O'Keefe, R. (2022). Bi-allelic FRA10AC1 variants in a multisystem human syndrome. Brain.
Metabolic Profiling of Rheumatoid Arthritis Neutrophils Reveals Altered Energy Metabolism That Is Not Affected by JAK Inhibition
Chokesuwattanaskul, S., Alarcon, M. F., Mangalakumaran, S., Grosman, R., Cross, A. L., Chapman, E. A., . . . Wright, H. L. (2022). Metabolic Profiling of Rheumatoid Arthritis Neutrophils Reveals Altered Energy Metabolism That Is Not Affected by JAK Inhibition. METABOLITES, 12(7). doi:10.3390/metabo12070650
Anti-Inflammatory Effects and Decreased Formation of Neutrophil Extracellular Traps by Enoxaparin in COVID-19 Patients
Saithong, S., Saisorn, W., Tovichayathamrong, P., Filbertine, G., Torvorapanit, P., Wright, H. L., . . . Chiewchengchol, D. (2022). Anti-Inflammatory Effects and Decreased Formation of Neutrophil Extracellular Traps by Enoxaparin in COVID-19 Patients. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(9). doi:10.3390/ijms23094805
Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis
Wilkinson, D. J., Falconer, A. M. D., Wright, H. L., Lin, H., Yamamoto, K., Cheung, K., . . . Rowan, A. D. (2022). Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis. FEBS JOURNAL, 289(1), 121-139. doi:10.1111/febs.16127
2021
The clinical significance of antinuclear antibodies and specific autoantibodies in juvenile and adult systemic lupus erythematosus patients
Rodsaward, P., Chottawornsak, N., Suwanchote, S., Rachayon, M., Deekajorndech, T., Wright, H. L., . . . Chiewchengchol, D. (2021). The clinical significance of antinuclear antibodies and specific autoantibodies in juvenile and adult systemic lupus erythematosus patients. ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, 39(4), 279-286. doi:10.12932/AP-211218-0465
Isolation of Microvesicles from Human Circulating Neutrophils
Zhan, D., McConachie, E., Edwards, S. W., Wright, H. L., Moots, R. J., & Honsawek, S. (2021). Isolation of Microvesicles from Human Circulating Neutrophils. BIO-PROTOCOL, 11(19). doi:10.21769/BioProtoc.3119
Internalization of Neutrophil-Derived Microvesicles Modulates TNFα-Stimulated Proinflammatory Cytokine Production in Human Fibroblast-Like Synoviocytes
Zhan, D., Cross, A., Wright, H. L., Moots, R. J., Edwards, S. W., & Honsawek, S. (2021). Internalization of Neutrophil-Derived Microvesicles Modulates TNFα-Stimulated Proinflammatory Cytokine Production in Human Fibroblast-Like Synoviocytes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(14). doi:10.3390/ijms22147409
COMPUTATIONAL ANALYSIS OF NEUTROPHIL GENE EXPRESSION REVEALS ACTIVATION SIGNATURES ASSOCIATED WITH DMARD REFRACTORY RHEUMATOID ARTHRITIS
Alarcon, M. F., Caamano-Gutierrez, E., Antczak, P., Moots, R. J., & Wright, H. L. (2021). COMPUTATIONAL ANALYSIS OF NEUTROPHIL GENE EXPRESSION REVEALS ACTIVATION SIGNATURES ASSOCIATED WITH DMARD REFRACTORY RHEUMATOID ARTHRITIS. In RHEUMATOLOGY Vol. 60. doi:10.1093/rheumatology/keab247.141
THE EFFECT OF JAK INHIBITION ON THE METABOLOME OF NEUTROPHILS FROM PATIENTS WITH RHEUMATOID ARTHRITIS
Alarcon, M. F., Grosman, R., Chokesuwattanaskul, S., Phelan, M., & Wright, H. L. (2021). THE EFFECT OF JAK INHIBITION ON THE METABOLOME OF NEUTROPHILS FROM PATIENTS WITH RHEUMATOID ARTHRITIS. In RHEUMATOLOGY Vol. 60. doi:10.1093/rheumatology/keab247.139
Neutrophils in the Pathogenesis of Rheumatoid Arthritis and Systemic Lupus Erythematosus: Same Foe Different MO
Fresneda Alarcon, M., McLaren, Z., & Wright, H. L. (2021). Neutrophils in the Pathogenesis of Rheumatoid Arthritis and Systemic Lupus Erythematosus: Same Foe Different MO. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.649693
Type I interferon regulates cytokine-delayed neutrophil apoptosis, reactive oxygen species production and chemokine expression
Glennon-Alty, L., Moots, R. J., Edwards, S. W., & Wright, H. L. (2021). Type I interferon regulates cytokine-delayed neutrophil apoptosis, reactive oxygen species production and chemokine expression. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 203(2), 151-159. doi:10.1111/cei.13525
Rheumatoid Arthritis Synovial Fluid Neutrophils Drive Inflammation Through Production of Chemokines, Reactive Oxygen Species, and Neutrophil Extracellular Traps
Wright, H. L., Lyon, M., Chapman, E. A., Moots, R. J., & Edwards, S. W. (2021). Rheumatoid Arthritis Synovial Fluid Neutrophils Drive Inflammation Through Production of Chemokines, Reactive Oxygen Species, and Neutrophil Extracellular Traps. FRONTIERS IN IMMUNOLOGY, 11. doi:10.3389/fimmu.2020.584116
2020
APPA (apocynin and paeonol) modulates pathological aspects of human neutrophil function, without supressing antimicrobial ability, and inhibits TNFα expression and signalling
Cross, A. L., Hawkes, J., Wright, H. L., Moots, R. J., & Edwards, S. W. (2020). APPA (apocynin and paeonol) modulates pathological aspects of human neutrophil function, without supressing antimicrobial ability, and inhibits TNFα expression and signalling. INFLAMMOPHARMACOLOGY, 28(5), 1223-1235. doi:10.1007/s10787-020-00715-5
Autoantibodies to neutrophil extracellular traps represent a potential serological biomarker in rheumatoid arthritis
de Bont, C. M., Stokman, M. E. M., Faas, P., Thurlings, R. M., Boelens, W. C., Wright, H. L., & Pruijn, G. J. M. (2020). Autoantibodies to neutrophil extracellular traps represent a potential serological biomarker in rheumatoid arthritis. JOURNAL OF AUTOIMMUNITY, 113. doi:10.1016/j.jaut.2020.102484
Defective Neutrophil Function in Patients with Sepsis is Mostly Restored by ex vivo Ascorbate Incubation
Sae-khow, K., Tachaboon, S., Wright, H., Edwards, S., Srisawat, N., Leelahavanichkul, A., & Chiewchengchol, D. (2020). Defective Neutrophil Function in Patients with Sepsis is Mostly Restored by ex vivo Ascorbate Incubation. Journal of Inflammation Research, 13, 263-274. doi:10.2147/JIR.S252433
SECUKINUMAB THERAPY DOES NOT AFFECT NEUTROPHIL HOST DEFENCE IN PSORIATIC ARTHRITIS
Cross, A., Hawkes, J., Frankland, H., Mediana, A., Wright, H., Goodson, N., . . . Moots, R. (2020). SECUKINUMAB THERAPY DOES NOT AFFECT NEUTROPHIL HOST DEFENCE IN PSORIATIC ARTHRITIS. In ANNALS OF THE RHEUMATIC DISEASES Vol. 79 (pp. 1353-1354). doi:10.1136/annrheumdis-2020-eular.4477
Modified culture protocol for differentiation of human promyelocytic leukaemia PLB-985 cell-line into mature neutrophil-like granulocytes
Shehu, S., Edwards, S. W., & Wright, H. L. (2020). Modified culture protocol for differentiation of human promyelocytic leukaemia PLB-985 cell-line into mature neutrophil-like granulocytes. The Journal of Immunology, 204(1_Supplement), 164.1. doi:10.4049/jimmunol.204.supp.164.1
P218 Interrogation of transcriptome data in RA for identifying disease susceptibility loci and predictors of treatment response
Smith, R., Goodson, N., Moots, R. J., & Wright, H. L. (2020). P218 Interrogation of transcriptome data in RA for identifying disease susceptibility loci and predictors of treatment response. Rheumatology, 59(Supplement_2). doi:10.1093/rheumatology/keaa111.213
Enhanced neutrophil functions during Opisthorchis viverrini infections and correlation with advanced periductal fibrosis.
Salao, K., Spofford, E. M., Price, C., Mairiang, E., Suttiprapa, S., Wright, H. L., . . . Edwards, S. W. (2020). Enhanced neutrophil functions during Opisthorchis viverrini infections and correlation with advanced periductal fibrosis.. International Journal for Parasitology, 50(2), 145-152. doi:10.1016/j.ijpara.2019.11.007
INTERROGATION OF TRANSCRIPTOME DATA IN RA FOR IDENTIFYING DISEASE SUSCEPTIBILITY LOCI AND PREDICTORS OF TREATMENT RESPONSE
Smith, R., Goodson, N., Moots, R. J., & Wright, H. L. (2020). INTERROGATION OF TRANSCRIPTOME DATA IN RA FOR IDENTIFYING DISEASE SUSCEPTIBILITY LOCI AND PREDICTORS OF TREATMENT RESPONSE. In RHEUMATOLOGY Vol. 59 (pp. 101). Retrieved from https://www.webofscience.com/
Modified culture protocol for differentiation of human promyelocytic leukaemia PLB-985 cell-line into mature neutrophil-like granulocytes
Shehu, S., Edwards, S. W., & Wright, H. L. (2020). Modified culture protocol for differentiation of human promyelocytic leukaemia PLB-985 cell-line into mature neutrophil-like granulocytes. In JOURNAL OF IMMUNOLOGY Vol. 204. Retrieved from https://www.webofscience.com/
Proinflammatory Neutrophil Function Is Modulated During Secukinumab Therapy in Psoriatic Arthritis Without Compromising Host Defence
Moots, R., Cross, A., Wright, H., Edwards, S., Goodson, N., Hawkes, J., . . . Frankland, H. (2020). Proinflammatory Neutrophil Function Is Modulated During Secukinumab Therapy in Psoriatic Arthritis Without Compromising Host Defence. In ARTHRITIS & RHEUMATOLOGY Vol. 72. Retrieved from https://www.webofscience.com/
2019
Human neutrophils activated via TLR8 promote Th17 polarization through IL-23
Tamassia, N., Arruda-Silva, F., Wright, H. L., Moots, R., Gardiman, E., Bianchetto-Aguilera, F., . . . Cassatella, M. (2019). Human neutrophils activated via TLR8 promote Th17 polarization through IL-23. Journal of Leukocyte Biology, 105(6), 1155-1165. doi:10.1002/JLB.MA0818-308R
012 Proteomic analysis of neutrophil extracellular traps in rheumatoid arthritis and systemic lupus erythematosus
Chapman, E. A., Lyon, M., Simpson, D., Mason, D., Beynon, R. J., Moots, R. J., & Wright, H. L. (2019). 012 Proteomic analysis of neutrophil extracellular traps in rheumatoid arthritis and systemic lupus erythematosus. Rheumatology, 58(Supplement_3). doi:10.1093/rheumatology/kez106.011
014 APPA inhibits neutrophil pro-inflammatory functions without impairing host defence: is this a potential new therapy for arthritis?
Cross, A. L., Hawkes, J. J., Wright, H. L., Moots, R. J., & Edwards, S. W. (2019). 014 APPA inhibits neutrophil pro-inflammatory functions without impairing host defence: is this a potential new therapy for arthritis?. Rheumatology, 58(Supplement_3). doi:10.1093/rheumatology/kez106.013
APPA, A POTENTIAL NEW THERAPY FOR OSTEOARTHRITIS, INHIBITS NEUTROPHIL PRO-INFLAMMATORY FUNCTIONS WITHOUT IMPAIRING HOST DEFENCE
Cross, A., Hawkes, J., Wright, H., Larkins, N., Edwards, S., & Moots, R. (2019). APPA, A POTENTIAL NEW THERAPY FOR OSTEOARTHRITIS, INHIBITS NEUTROPHIL PRO-INFLAMMATORY FUNCTIONS WITHOUT IMPAIRING HOST DEFENCE. In OSTEOARTHRITIS AND CARTILAGE Vol. 27 (pp. S189-S190). doi:10.1016/j.joca.2019.02.290
APPA INHIBITS NEUTROPHIL PRO-INFLAMMATORY FUNCTIONS WITHOUT IMPAIRING HOST DEFENCE: IS THIS A POTENTIAL NEW THERAPY FOR ARTHRITIS?
Cross, A. L., Hawkes, J. J., Wright, H. L., Moots, R. J., & Edwards, S. W. (2019). APPA INHIBITS NEUTROPHIL PRO-INFLAMMATORY FUNCTIONS WITHOUT IMPAIRING HOST DEFENCE: IS THIS A POTENTIAL NEW THERAPY FOR ARTHRITIS?. In RHEUMATOLOGY Vol. 58 (pp. 46). Retrieved from https://www.webofscience.com/
Caught in a Trap? Proteomic analysis of neutrophil extracellular traps in rheumatoid arthritis and systemic lupus erythematosus
Chapman, E., Lyon, M., Simpson, D., Mason, D., Beynon, R., Moots, R., & Wright, H. L. (2019). Caught in a Trap? Proteomic analysis of neutrophil extracellular traps in rheumatoid arthritis and systemic lupus erythematosus. Frontiers in Immunology, 10. doi:10.3389/fimmu.2019.00423
Computational approaches to neutrophil transcriptome analysis
Wright, H., & Antczak, P. (2019). Computational approaches to neutrophil transcriptome analysis. In EUROPEAN JOURNAL OF CLINICAL INVESTIGATION Vol. 49 (pp. 130). Retrieved from https://www.webofscience.com/
PROTEOMIC ANALYSIS OF NEUTROPHIL EXTRACELLULAR TRAPS IN RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS
Chapman, E. A., Lyon, M., Simpson, D., Mason, D., Beynon, R. J., Moots, R. J., & Wright, H. L. (2019). PROTEOMIC ANALYSIS OF NEUTROPHIL EXTRACELLULAR TRAPS IN RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS. RHEUMATOLOGY, 58. Retrieved from https://www.webofscience.com/
Proteomic analysis of neutrophil extracellular traps in rheumatoid arthritis and systemic lupus erythematosus
Chapman, E., Lyon, M., Simpson, D., Mason, D., Beynon, R., Moots, R., & Wright, H. (2019). Proteomic analysis of neutrophil extracellular traps in rheumatoid arthritis and systemic lupus erythematosus. In EUROPEAN JOURNAL OF CLINICAL INVESTIGATION Vol. 49 (pp. 63). Retrieved from https://www.webofscience.com/
2018
A robust intracellular metabolite extraction protocol for human neutrophil metabolic profiling
Chokesuwattanaskul, S., Phelan, M., Edwards, S., & Wright, H. L. (2018). A robust intracellular metabolite extraction protocol for human neutrophil metabolic profiling. PLoS One, 13(12). doi:10.1371/journal.pone.0209270
1H NMR metabolomics identifies underlying inflammatory pathology in osteoarthritis and rheumatoid arthritis synovial joints
Anderson, J., Chokesuwattanaskul, S., Phelan, M., Welting, T., Lian, L. Y., Peffers, M., & Wright, H. L. (2018). 1H NMR metabolomics identifies underlying inflammatory pathology in osteoarthritis and rheumatoid arthritis synovial joints. Journal of Proteome Research, 17(11), 3780-3790. doi:10.1021/acs.jproteome.8b00455
Neutrophils and redox stress in the pathogenesis of autoimmune disease
Glennon-Alty, L., Hackett, A. P., Chapman, E. A., & Wright, H. L. (2018). Neutrophils and redox stress in the pathogenesis of autoimmune disease. FREE RADICAL BIOLOGY AND MEDICINE, 125, 25-35. doi:10.1016/j.freeradbiomed.2018.03.049
Opisthorchiasis-Induced Cholangiocarcinoma: How Innate Immunity May Cause Cancer
Edwards, S., Spofford, E., Price, C., Wright, H. L., Salao, K., Suttiprapa, S., & Sripa, B. (2018). Opisthorchiasis-Induced Cholangiocarcinoma: How Innate Immunity May Cause Cancer. Advances in Parasitology. doi:10.1016/bs.apar.2018.05.006
The CDK inhibitor purvalanol A induces neutrophil apoptosis and increases the turnover rate of Mcl-1: potential role of p38-MAPK in regulation of Mcl-1 turnover
Phoomvuthisarn, P., Cross, A., Glennon-Alty, L., Wright, H. L., & Edwards, S. W. (2018). The CDK inhibitor purvalanol A induces neutrophil apoptosis and increases the turnover rate of Mcl-1: potential role of p38-MAPK in regulation of Mcl-1 turnover. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 192(2), 171-180. doi:10.1111/cei.13107
250 The effect of JAK inhibition on neutrophil killing, netosis and metabolism in rheumatoid arthritis
Chokesuwattanaskul, S., Mangalakumaran, S., Chapman, E., Cross, A., Phelan, M. M., Lian, L. -Y., . . . Wright, H. L. (2018). 250 The effect of JAK inhibition on neutrophil killing, netosis and metabolism in rheumatoid arthritis. Rheumatology, 57(suppl_3). doi:10.1093/rheumatology/key075.474
251 Synovial fluid metabolite profiles differ between osteoarthritis and rheumatoid arthritis
Anderson, J. R., Chokesuwattanaskul, S., Phelan, M. P., Welting, T. J. M., Lian, L. -Y., Peffers, M. J., & Wright, H. L. (2018). 251 Synovial fluid metabolite profiles differ between osteoarthritis and rheumatoid arthritis. Rheumatology, 57(suppl_3). doi:10.1093/rheumatology/key075.475
Anti-neutrophil cytoplasmic antibodies and their clinical significance
Suwanchote, S., Rachayon, M., Rodsaward, P., Wongpiyabovorn, J., Deekajorndech, T., Wright, H. L., . . . Chiewchengchol, D. (2018). Anti-neutrophil cytoplasmic antibodies and their clinical significance. CLINICAL RHEUMATOLOGY, 37(4), 875-884. doi:10.1007/s10067-018-4062-x
Neutrophil activation signature in juvenile idiopathic arthritis indicates the presence of low-density granulocytes
Ramanathan, K., Glaser, A., Lythgoe, H., Ong, J., Beresford, M. W., Midgley, A., & Wright, H. L. (2018). Neutrophil activation signature in juvenile idiopathic arthritis indicates the presence of low-density granulocytes. RHEUMATOLOGY, 57(3), 488-498. doi:10.1093/rheumatology/kex441
2017
Janus kinase inhibitors prevent migration of rheumatoid arthritis neutrophils towards interleukin-8, but do not inhibit priming of the respiratory burst or reactive oxygen species production
Mitchell, T. S., Moots, R. J., & Wright, H. L. (2017). Janus kinase inhibitors prevent migration of rheumatoid arthritis neutrophils towards interleukin-8, but do not inhibit priming of the respiratory burst or reactive oxygen species production. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 189(2), 250-258. doi:10.1111/cei.12970
Neutrophil biomarkers predict response to therapy with tumor necrosis factor inhibitors in rheumatoid arthritis
Wright, H. L., Cox, T., Moots, R. J., & Edwards, S. W. (2017). Neutrophil biomarkers predict response to therapy with tumor necrosis factor inhibitors in rheumatoid arthritis. Journal of Leukocyte Biology, 101(3), 785-795. doi:10.1189/jlb.5A0616-258R
Low-density granulocytes: functionally distinct, immature neutrophils in rheumatoid arthritis with altered properties and defective TNF signalling
Wright, H. L., Makki, F. A., Moots, R. J., & Edwards, S. W. (2017). Low-density granulocytes: functionally distinct, immature neutrophils in rheumatoid arthritis with altered properties and defective TNF signalling. JOURNAL OF LEUKOCYTE BIOLOGY, 101(2), 599-611. doi:10.1189/jlb.5A0116-022R
GARROD PRIZE WINNER. INSIDE THE CHAMBER OF SECRETS: OMICS ANALYSIS OF NEUTROPHILS IN RHEUMATOID ARTHRITIS
Wright, H. L. (2017). GARROD PRIZE WINNER. INSIDE THE CHAMBER OF SECRETS: OMICS ANALYSIS OF NEUTROPHILS IN RHEUMATOID ARTHRITIS. In RHEUMATOLOGY Vol. 56 (pp. 6). Retrieved from https://www.webofscience.com/
2016
Human neutrophils in auto-immunity
Thieblemont, N., Wright, H. L., Edwards, S. W., & Witko-Sarsat, V. (2016). Human neutrophils in auto-immunity. SEMINARS IN IMMUNOLOGY, 28(2), 159-173. doi:10.1016/j.smim.2016.03.004
The Cdk2 inhibitor, Purvalanol A, induces apoptosis is myeloid cells via p38-MAPK dependent turnover of Mcl-1
Phoomvuthisarn, P., Wright, H. L., Clark, R. E., Mutirangura, A., & Edwards, S. W. (2016). The Cdk2 inhibitor, Purvalanol A, induces apoptosis is myeloid cells via p38-MAPK dependent turnover of Mcl-1. In EUROPEAN JOURNAL OF CLINICAL INVESTIGATION Vol. 46 (pp. 81). Retrieved from https://www.webofscience.com/
Differential changes in gene expression in human neutrophils following TNF-α stimulation: Up-regulation of anti-apoptotic proteins and down-regulation of proteins involved in death receptor signaling
Chiewchengchol, D., Wright, H. L., Thomas, H. B., Lam, C. W., Roberts, K. J., Hirankarn, N., . . . Edwards, S. W. (2016). Differential changes in gene expression in human neutrophils following TNF-α stimulation: Up-regulation of anti-apoptotic proteins and down-regulation of proteins involved in death receptor signaling. IMMUNITY INFLAMMATION AND DISEASE, 4(1), 35-44. doi:10.1002/iid3.90
2015
Whose gene is it anyway? The effect of preparation purity on neutrophil transcriptome studies
Thomas, H., Moots, R., Edwards, S., & Wright, H. (2015). Whose gene is it anyway? The effect of preparation purity on neutrophil transcriptome studies. PLoS One, 10(9). doi:10.1371/journal.pone.0138982
Killing of Escherichia coli by Crohn's Disease Monocyte-derived Macrophages and Its Enhancement by Hydroxychloroquine and Vitamin D
Flanagan, P., Chiewchengchol, D., Wright, H., Edwards, S., Alswied, A., Satsangi, J., . . . Campbell, B. (2015). Killing of Escherichia coli by Crohn's Disease Monocyte-derived Macrophages and Its Enhancement by Hydroxychloroquine and Vitamin D. Inflammatory Bowel Diseases®, 21(7), 1499-1510. doi:10.1097/MIB.0000000000000387
Synovial fluid IL-6 concentrations associated with positive response to tocilizumab in an RA patient with failed response to anti-TNF and rituximab
Wright, H. L., Mewar, D., Bucknall, R. C., Edwards, S. W., & Moots, R. J. (2015). Synovial fluid IL-6 concentrations associated with positive response to tocilizumab in an RA patient with failed response to anti-TNF and rituximab. RHEUMATOLOGY, 54(4), 743-744. doi:10.1093/rheumatology/keu488
Interferon gene expression signature in rheumatoid arthritis neutrophils correlates with a good response to TNFi therapy
Wright, H., Thomas, H., Moots, R., & Edwards, S. (2015). Interferon gene expression signature in rheumatoid arthritis neutrophils correlates with a good response to TNFi therapy. Rheumatology, 54(1), 188-193. doi:10.1093/rheumatology/keu299
2014
A lack of confirmation with alternative assays questions the validity of IL-17A expression in human neutrophils using immunohistochemistry
Tamarozzi, F., Wright, H. L., Thomas, H. B., Edwards, S. W., & Taylor, M. J. (2014). A lack of confirmation with alternative assays questions the validity of IL-17A expression in human neutrophils using immunohistochemistry. IMMUNOLOGY LETTERS, 162(2), 194-198. doi:10.1016/j.imlet.2014.10.025
232. Interferons Alter the Response of Neutrophils to Inflammatory Cytokines in vitro
Wright, H. L., Moots, R. J., & Edwards, S. W. (2014). 232. Interferons Alter the Response of Neutrophils to Inflammatory Cytokines in vitro. Rheumatology, 53(suppl_1), i147. doi:10.1093/rheumatology/keu117.001
Effects of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo
Wright, H. L., Cross, A. L., Edwards, S. W., & Moots, R. J. (2014). Effects of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo. Rheumatology, 53(7), 1321-1331. doi:10.1093/rheumatology/keu035
Human filarial <i>Wolbachia</i> lipopeptide directly activates human neutrophils <i>in vitro</i>
Tamarozzi, F., Wright, H. L., Johnston, K. L., Edwards, S. W., Turner, J. D., & Taylor, M. J. (2014). Human filarial <i>Wolbachia</i> lipopeptide directly activates human neutrophils <i>in vitro</i>. PARASITE IMMUNOLOGY, 36(10), 494-502. doi:10.1111/pim.12122
The multifactorial role of neutrophils in rheumatoid arthritis
Wright, H. L., Moots, R. J., & Edwards, S. W. (2014). The multifactorial role of neutrophils in rheumatoid arthritis. NATURE REVIEWS RHEUMATOLOGY, 10(10), 593-601. doi:10.1038/nrrheum.2014.80
2013
DcR3 Mutations in Patients with Juvenile-onset Systemic Lupus Erythematosus Lead to Enhanced Lymphocyte Proliferation
Chokdeemeeboon, C., Amrnarinthnukrowh, P., Tongkobpetch, S., Srichomtong, C., Deekajorndech, T., Rianthavorn, P., . . . Shotelersuk, V. (2013). DcR3 Mutations in Patients with Juvenile-onset Systemic Lupus Erythematosus Lead to Enhanced Lymphocyte Proliferation. JOURNAL OF RHEUMATOLOGY, 40(8), 1316-1326. doi:10.3899/jrheum.121285
RNA-Seq Reveals Activation of Both Common and Cytokine-Specific Pathways following Neutrophil Priming
Wright, H. L., Thomas, H. B., Moots, R. J., & Edwards, S. W. (2013). RNA-Seq Reveals Activation of Both Common and Cytokine-Specific Pathways following Neutrophil Priming. PLOS ONE, 8(3). doi:10.1371/journal.pone.0058598
INTERFERON GENE EXPRESSION SIGNATURE IN NEUTROPHILS FROM RA PATIENTS PRE- AND POST-ANTI-TNF THERAPY
Wright, H. L., Thomas, H. B., Moots, R., & Edwards, S. W. (2013). INTERFERON GENE EXPRESSION SIGNATURE IN NEUTROPHILS FROM RA PATIENTS PRE- AND POST-ANTI-TNF THERAPY. RHEUMATOLOGY, 52, 46. Retrieved from https://www.webofscience.com/
Interferon gene expression signature in rheumatoid arthritis neutrophils predicts response to anti-TNF therapy
Wright, H. L., Thomas, H. B., Moots, R. J., & Edwards, S. W. (2013). Interferon gene expression signature in rheumatoid arthritis neutrophils predicts response to anti-TNF therapy. In IMMUNOLOGY Vol. 140 (pp. 161). Retrieved from https://www.webofscience.com/
2012
Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy
Wright, H. L., Bucknall, R. C., Moots, R. J., & Edwards, S. W. (2012). Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy. Rheumatology, 51(3), 451-459. doi:10.1093/rheumatology/ker338
Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy
Wright, H. L., Bucknall, R. C., Moots, R. J., & Edwards, S. W. (2012). Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy. RHEUMATOLOGY, 51(3), 451-459. doi:10.1093/rheumatology/ker338
DISCOVERING CYTOKINE-SPECIFIC GENE EXPRESSION PROFILES IN INFLAMMATORY NEUTROPHILS USING WHOLE TRANSCRIPTOME SEQUENCING
Wright, H. L., Thomas, H. B., Moots, R. J., & Edwards, S. W. (2012). DISCOVERING CYTOKINE-SPECIFIC GENE EXPRESSION PROFILES IN INFLAMMATORY NEUTROPHILS USING WHOLE TRANSCRIPTOME SEQUENCING. In RHEUMATOLOGY Vol. 51 (pp. 140-141). Retrieved from https://www.webofscience.com/
The Effects of TNF Stimulation On Control of Apoptosis in Neutrophils.
Chiewchengchol, D., Lam, C., Roberts, K., Wright, H., Thomas, H., Moots, R., & Edwards, S. (2012). The Effects of TNF Stimulation On Control of Apoptosis in Neutrophils.. In ARTHRITIS AND RHEUMATISM Vol. 64 (pp. S461). Retrieved from https://www.webofscience.com/
2011
Changes in expression of membrane TNF, NF-κB activation and neutrophil apoptosis during active and resolved inflammation
Wright, H. L., Chikura, B., Bucknall, R. C., Moots, R. J., & Edwards, S. W. (2011). Changes in expression of membrane TNF, NF-κB activation and neutrophil apoptosis during active and resolved inflammation. ANNALS OF THE RHEUMATIC DISEASES, 70(3), 537-543. doi:10.1136/ard.2010.138065
2010
Neutrophil function in inflammation and inflammatory diseases
Wright, H. L., Moots, R. J., Bucknall, R. C., & Edwards, S. W. (2010). Neutrophil function in inflammation and inflammatory diseases. RHEUMATOLOGY, 49(9), 1618-1631. doi:10.1093/rheumatology/keq045
2009
Neutrophil function in rheumatoid arthritis
Wright, H. L. (2009). Neutrophil function in rheumatoid arthritis. (PhD Thesis, University of Liverpool).