Research
Cross-seeding of amyloid proteins
I am interested in how amyloid proteins interact with one-another and how this can alter the disease progression and outcomes. Using a combination of biophysical and structural techniques I aim to understand how interactions between these proteins can alter their aggregation kinetics, morphology and pathology. Alongside this work I also aim to understand the structural differences between model amyloid assemblies generated in vitro and the structure of plaques in the body.
Additional factors that affect amyloid deposition in vivo.
Another key aim of our group is to understand the role accessory molecules have in the development and pathology of amyloid plaques. Amyloid plaques are a complex mixture of molecules and can include glycosaminoglycans, additional proteins, metal ions etc. We are trying to un-pick the key components of these assemblies and understand their role in amyloid formation using a wide range of techniques from histology to nuclear magnetic resonance.
Research grants
Neuroblastology! – Brain in a bottle
BIOCHEMICAL SOCIETY (UK)
November 2015 - May 2017