Publications
2023
Medin amyloid may drive arterial aging and disease in the periphery and brain
Madine, J., Davies, H. A., Migrino, R. Q., Ruotsalainen, S. E., Wagner, J., & Neher, J. J. (2023). Medin amyloid may drive arterial aging and disease in the periphery and brain. NATURE AGING. doi:10.1038/s43587-023-00481-3
2022
Medin co-aggregates with vascular amyloid-β in Alzheimer's disease
Wagner, J., Degenhardt, K., Veit, M., Louros, N., Konstantoulea, K., Skodras, A., . . . Neher, J. J. (2022). Medin co-aggregates with vascular amyloid-β in Alzheimer's disease. NATURE, 612(7938), 123-+. doi:10.1038/s41586-022-05440-3
Is There Enough Evidence to Support the Role of Glycosaminoglycans and Proteoglycans in Thoracic Aortic Aneurysm and Dissection?—A Systematic Review
Rai, P., Robinson, L., Davies, H. A., Akhtar, R., Field, M., & Madine, J. (n.d.). Is There Enough Evidence to Support the Role of Glycosaminoglycans and Proteoglycans in Thoracic Aortic Aneurysm and Dissection?—A Systematic Review. International Journal of Molecular Sciences, 23(16), 9200. doi:10.3390/ijms23169200
Development of amyloid beta gold nanorod aggregates as optoacoustic probes
Soliman, M. G., Davies, H. A., Sharkey, J., Levy, R., & Madine, J. (2022). Development of amyloid beta gold nanorod aggregates as optoacoustic probes. PLOS ONE, 17(3). doi:10.1371/journal.pone.0259608
Time-dependent mechanical behaviour of the aortic chronic dissection flap.
Panpho, P., Yang, Y., Davies, H. A., Nawaytou, O., Harky, A., Torella, F., . . . Akhtar, R. (2022). Time-dependent mechanical behaviour of the aortic chronic dissection flap.. Interactive cardiovascular and thoracic surgery. doi:10.1093/icvts/ivac029
Rapid evaporative ionization mass spectrometry (intelligent knife) for point-of-care testing in acute aortic dissection surgery
Davies, H. A., Caamano-Gutierrez, E., Sarsby, J., Chim, Y. H., Barrett, S., Nawaytou, O., . . . Madine, J. (2022). Rapid evaporative ionization mass spectrometry (intelligent knife) for point-of-care testing in acute aortic dissection surgery. Interactive CardioVascular and Thoracic Surgery. doi:10.1093/icvts/ivac019
2021
Abstract 11596: Amyloidogenic Medin Induces Endothelial Cell Prothrombotic Activation
Karamanova, N., Truran, S., Davies, H., Madine, J., & Migrino, R. Q. (2021). Abstract 11596: Amyloidogenic Medin Induces Endothelial Cell Prothrombotic Activation. Circulation, 144(Suppl_1). doi:10.1161/circ.144.suppl_1.11596
Development of amyloid beta gold nanorod aggregates as optoacoustic probes
Exploring the potential of rapid evaporative ionization mass spectrometry (Intelligent Knife) for point-of-care testing in aortic surgery
Davies, H. A., Caamano-Gutierrez, E., Sarsby, J., Nawaytou, O., Harky, A., Akhtar, R., . . . Madine, J. (n.d.). Exploring the potential of rapid evaporative ionization mass spectrometry (Intelligent Knife) for point-of-care testing in aortic surgery. European Journal of Cardio-Thoracic Surgery. doi:10.1093/ejcts/ezab166
2020
Medin amyloid forms age‐associated aggregates in the brain vasculature and may contribute to cerebral β‐amyloidosis
Wagner, J., Degenhardt, K., Wild, K., Obermüller, U., Haesler, L. M., Koppelmann, A. J., . . . Neher, J. J. (2020). Medin amyloid forms age‐associated aggregates in the brain vasculature and may contribute to cerebral β‐amyloidosis. Alzheimer's & Dementia, 16(S2). doi:10.1002/alz.042861
Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice.
Degenhardt, K., Wagner, J., Skodras, A., Candlish, M., Koppelmann, A. J., Wild, K., . . . Neher, J. J. (2020). Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice.. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.2011133117
Cerebrovascular medin is associated with Alzheimer's disease and vascular dementia.
Migrino, R. Q., Karamanova, N., Truran, S., Serrano, G. E., Davies, H. A., Madine, J., & Beach, T. G. (2020). Cerebrovascular medin is associated with Alzheimer's disease and vascular dementia.. Alzheimer's and Dementia, 12(1), e12072. doi:10.1002/dad2.12072
Medin Oligomer Membrane Pore Formation: A Potential Mechanism of Vascular Dysfunction
Younger, S., Jang, H., Davies, H. A., Niemiec, M. J., Garcia, J. G. N., Nussinov, R., . . . Arce, F. T. (2020). Medin Oligomer Membrane Pore Formation: A Potential Mechanism of Vascular Dysfunction. BIOPHYSICAL JOURNAL, 118(11), 2769-2782. doi:10.1016/j.bpj.2020.04.026
Endothelial Immune Activation by Medin: Potential Role in Cerebrovascular Disease and Reversal by Monosialoganglioside‐Containing Nanoliposomes
Karamanova, N., Truran, S., Serrano, G. E., Beach, T. G., Madine, J., Weissig, V., . . . Migrino, R. Q. (2020). Endothelial Immune Activation by Medin: Potential Role in Cerebrovascular Disease and Reversal by Monosialoganglioside‐Containing Nanoliposomes. Journal of the American Heart Association, 9(2). doi:10.1161/JAHA.119.014810
2019
2.8 Unique Patterns of Elastin Degradation in Ascending Aortic Aneurysms in Bicuspid Aortic Valve Patients
Chim, Y. H., Davies, H., Nawaytou, O., Field, M., Madine, J., & Akhtar, R. (2019). 2.8 Unique Patterns of Elastin Degradation in Ascending Aortic Aneurysms in Bicuspid Aortic Valve Patients. Artery Research, 25(S1), S19. doi:10.2991/artres.k.191224.013
P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection
Panpho, P., Davies, H., Field, M., Madine, J., Yang, Y., & Akhtar, R. (2019). P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection. Artery Research, 25(S1), S43. doi:10.2991/artres.k.191224.036
Bicuspid valve aortopathy is associated with distinct patterns of matrix degradation
Chim, Y. H., Davies, H., Mason, D., Nawaytou, O., Field, M., Madine, J., & Akhtar, R. (2019). Bicuspid valve aortopathy is associated with distinct patterns of matrix degradation. The Journal of Thoracic and Cardiovascular Surgery, 160(6), E239-E257. doi:10.1016/j.jtcvs.2019.08.094
Idiopathic degenerative thoracic aneurysms are associated with increased aortic medial amyloid
Davies, H. A., Caamano-Gutierrez, E., Chim, Y. H., Field, M., Nawaytou, O., Ressel, L., . . . Madine, J. (n.d.). Idiopathic degenerative thoracic aneurysms are associated with increased aortic medial amyloid. Amyloid: international journal of experimental and clinical investigation, 26(3), 148-155. doi:10.1080/13506129.2019.1625323
Macro- and Micro-mechanical Properties of the Ovine Aorta: Correlation with Regional Variations in Collagen, Elastin and Glycosominoglycan Levels
Panpho, P., Brendan, G., Chim, Y. H., Davies, H., Field, M., Madine, J., & Akhtar, R. (n.d.). Macro- and Micro-mechanical Properties of the Ovine Aorta: Correlation with Regional Variations in Collagen, Elastin and Glycosominoglycan Levels. Artery Research, 25(1-2), 27-36. doi:10.2991/artres.k.191114.003
Quality of Reporting in Human Aortic Tissue Research – A Systematic Review
Chim, Y. -H., Caamaño-Gutiérrez, E., Birla, R., Madine, J., Field, M., Akhtar, R., & Davies, H. A. (n.d.). Quality of Reporting in Human Aortic Tissue Research – A Systematic Review. Artery Research. doi:10.2991/artres.k.191106.003
BAV AORTOPATHY EXHIBITS A UNIQUE PATTERN OF AORTIC DEGRADATION EVEN THOUGH THE CLINICAL RISK OF RUPTURE MIRRORS OTHER ANEURYSMS - A MICROMECHANICAL AND MICROSTRUCTURAL APPROACH
Chim, Y. H., Davies, H., Field, M., Madine, J., & Akhtar, R. (2019). BAV AORTOPATHY EXHIBITS A UNIQUE PATTERN OF AORTIC DEGRADATION EVEN THOUGH THE CLINICAL RISK OF RUPTURE MIRRORS OTHER ANEURYSMS - A MICROMECHANICAL AND MICROSTRUCTURAL APPROACH. In HEART Vol. 105 (pp. A162). doi:10.1136/heartjnl-2019-BCS.196
Abstract TP557: Endothelial Cell Proinflammatory Priming by Amyloidogenic Medin via NFκB and Inflammasome Pathways and Reversal by Monosialoganglioside Nanoliposomes
Karamanova, N., Truran, S., Madine, J., Davies, H., Zhang, W., Franco, D., . . . Migrino, R. Q. (2019). Abstract TP557: Endothelial Cell Proinflammatory Priming by Amyloidogenic Medin via NFκB and Inflammasome Pathways and Reversal by Monosialoganglioside Nanoliposomes. Stroke, 50(Suppl_1). doi:10.1161/str.50.suppl_1.tp557
Abstract WMP73: Discerning How Vascular Inflammation Modulates Neuroinflammation Using Novel Vascular Brain Organ-On-A-Chip: Proof-of-Concept Study
Veldhuizen, J., Truran, S., Madine, J., Davies, H., Karamanova, N., Nikkhah, M., & Migrino, R. Q. (2019). Abstract WMP73: Discerning How Vascular Inflammation Modulates Neuroinflammation Using Novel Vascular Brain Organ-On-A-Chip: Proof-of-Concept Study. Stroke, 50(Suppl_1). doi:10.1161/str.50.suppl_1.wmp73
Biochemical Characteristics of the Aortic True Lumen Wall, False Lumen Wall and Flap During the Acute Phases of Type A Aortic Dissection in Humans
Harky, A., Chim, Y. H., Davies, H. A., Field, M., Nawaytou, O., Akhtar, R., & Madine, J. (2019). Biochemical Characteristics of the Aortic True Lumen Wall, False Lumen Wall and Flap During the Acute Phases of Type A Aortic Dissection in Humans. In CIRCULATION Vol. 140. Retrieved from https://www.webofscience.com/
2018
P75 DIFFERENTIAL ELASTIN DEGRADATION AND MICROMECHANICAL PROPERTIES IN ASCENDING AORTIC ANEURYSM GROUPS: STATISTICAL MODELLING
Chim, Y. H., Davies, H., Diaz De la O, F., Field, M., Madine, J., & Akhtar, R. (n.d.). P75 DIFFERENTIAL ELASTIN DEGRADATION AND MICROMECHANICAL PROPERTIES IN ASCENDING AORTIC ANEURYSM GROUPS: STATISTICAL MODELLING. Artery Research, 24(C), 100. doi:10.1016/j.artres.2018.10.128
Human cerebral collateral arteriole function in subjects with normal cognition, mild cognitive impairment, and dementia
Migrino, R. Q., Truran, S., Karamanova, N., Davies, H., Madine, J., Reaven, P., & Beach, T. G. (2018). Human cerebral collateral arteriole function in subjects with normal cognition, mild cognitive impairment, and dementia. American Journal of Physiology: Heart and Circulatory Physiology, 315(2), H284-H290. doi:10.1152/ajpheart.00206.2018
Insights into the Origin of Distinct Medin Fibril Morphologies Induced by Incubation Conditions and Seeding
Davies, H., Lee, C. F., Miller, L., Liu, L., & Madine, J. (2018). Insights into the Origin of Distinct Medin FibrilMorphologies Induced by Incubation Conditionsand Seeding. International Journal of Molecular Sciences, 19(5), 1-15. doi:10.3390/ijms19051357
Amyloidogenic Medin Impairs Endothelial Cell Autophagy and Viability that is Reversed by Monosialoganglioside Nanoliposomes
Karamanova, N., Truran, S., Weissig, V., Madine, J., Davies, H., Guzman‐Villanueva, D., & Migrino, R. (2018). Amyloidogenic Medin Impairs Endothelial Cell Autophagy and Viability that is Reversed by Monosialoganglioside Nanoliposomes. The FASEB Journal, 32(S1). doi:10.1096/fasebj.2018.32.1_supplement.846.16
Peripheral Adipose Arteriole Dilator Response to Amyloid Proteins and Palmitic Acid Recapitulates Central Leptomeningeal Arteriole Response: Validation of a Novel Human Tissue Model
Truran, S., Karamanova, N., Serrano, G., Madine, J., Davies, H., Beach, T., & Migrino, R. Q. (2018). Peripheral Adipose Arteriole Dilator Response to Amyloid Proteins and Palmitic Acid Recapitulates Central Leptomeningeal Arteriole Response: Validation of a Novel Human Tissue Model. The FASEB Journal, 32(S1). doi:10.1096/fasebj.2018.32.1_supplement.712.6
Abstract WP416: Comparison of Ex-vivo Human Leptomeningeal Arteriole Function in Cognitively Normal and Dementia Disorders From Rapid Autopsy Brain Donors
Madrigal, C., Truran, S., Karamanova, N., Serrano, G., Madine, J., Davies, H., . . . Migrino, R. Q. (2018). Abstract WP416: Comparison of Ex-vivo Human Leptomeningeal Arteriole Function in Cognitively Normal and Dementia Disorders From Rapid Autopsy Brain Donors. Stroke, 49(Suppl_1). doi:10.1161/str.49.suppl_1.wp416
2017
Amyloidogenic Medin Induces Endothelial Dysfunction and Vascular Inflammation through the Receptor for Advanced Glycation Endproducts
Migrino, M., Davies, H. A., Truran, S., Karamanova, N., Franco, D. A., Beach, T. G., . . . Madine, J. (2017). Amyloidogenic Medin Induces Endothelial Dysfunction and Vascular Inflammation through the Receptor for Advanced Glycation Endproducts. Cardiovascular Research, 113(11), 1389-1402. doi:10.1093/cvr/cvx135
Amyloidogenic Medin Induces Endothelial Dysfunction and Vascular Inflammation Through the Receptor for Advanced Glycation Endproducts
Migrino, R. Q., Davies, H., Truran, S., Karamanova, N., Franco, D. A., Serrano, G., . . . Madine, J. (2017). Amyloidogenic Medin Induces Endothelial Dysfunction and Vascular Inflammation Through the Receptor for Advanced Glycation Endproducts. In FASEB JOURNAL Vol. 31. Retrieved from https://www.webofscience.com/
Probing Medin Monomer Structure and its Amyloid Nucleation Using 13C-Direct Detection NMR in Combination with Structural Bioinformatics
Davies, H. A., Rigden, D. J., Phelan, M. M., & Madine, J. (2017). Probing Medin Monomer Structure and its Amyloid Nucleation Using 13C-Direct Detection NMR in Combination with Structural Bioinformatics. Scientific Reports, 7. doi:10.1038/srep45224
2016
HUMAN MICROVASCULAR ENDOTHELIAL DYSFUNCTION INDUCED BY AMYLOIDOGENIC MEDIN PROTEIN
Migrino, R. Q., Truran, S., Karamanova, N., Franco, D., Davies, H. A., Burciu, C., & Madine, J. (2016). HUMAN MICROVASCULAR ENDOTHELIAL DYSFUNCTION INDUCED BY AMYLOIDOGENIC MEDIN PROTEIN. In JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY Vol. 67 (pp. 2310). doi:10.1016/S0735-1097(16)32311-7
<SUP>1</SUP>H, <SUP>15</SUP>N and <SUP>13</SUP>C assignment of the amyloidogenic protein medin using fast-pulsing NMR techniques
Davies, H. A., Phelan, M. M., & Madine, J. (2016). <SUP>1</SUP>H, <SUP>15</SUP>N and <SUP>13</SUP>C assignment of the amyloidogenic protein medin using fast-pulsing NMR techniques. BIOMOLECULAR NMR ASSIGNMENTS, 10(1), 75-77. doi:10.1007/s12104-015-9641-z
Nanoliposomes protect against human arteriole endothelial dysfunction induced by β-amyloid peptide
Truran, S., Weissig, V., Madine, J., Davies, H. A., Guzman-Villanueva, D., Franco, D. A., . . . Migrino, R. Q. (2016). Nanoliposomes protect against human arteriole endothelial dysfunction induced by β-amyloid peptide. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 36(2), 405-412. doi:10.1177/0271678X15610134
2015
Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial Amyloid
Davies, H., Phelan, M., Wilkinson, M., Migrino, R., Truran, S., Franco, D. A., . . . Madine, J. (2015). Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial Amyloid. Biophysical Journal, 109(11), 2363-2370. doi:10.1016/j.bpj.2015.10.034
β-amyloid Peptide-Induced Human Arteriole Endothelial Dysfunction is Attenuated by Nanoliposomes
Guzman-Villanueva, D., Madine, J., Truran, S., Davies, H., Burciu, C., Franco, D., . . . Migrino, R. (2015). β-amyloid Peptide-Induced Human Arteriole Endothelial Dysfunction is Attenuated by Nanoliposomes. In FASEB JOURNAL Vol. 29. Retrieved from https://www.webofscience.com/
Comparison with amyloid-beta reveal an aspartate residue that stabilizes fibrils of the aortic amyloid polypeptide medin
Davies, H., Madine, J., & Middleton, D. (2015). Comparison with amyloid-beta reveal an aspartate residue that stabilizes fibrils of the aortic amyloid polypeptide medin. The Journal of Biological Chemistry, 290, 7791-7803. doi:10.1074/jbc.M114.602177
2014
Expression and purification of the aortic amyloid polypeptide medin
Davies, H. A., Wilkinson, M. C., Gibson, R. P., & Middleton, D. A. (2014). Expression and purification of the aortic amyloid polypeptide medin. PROTEIN EXPRESSION AND PURIFICATION, 98, 32-37. doi:10.1016/j.pep.2014.02.009
2013
Heparin Promotes the Rapid Fibrillization of a Peptide with Low Intrinsic Amyloidogenicity
Madine, J., Davies, H. A., Hughes, E., & Middleton, D. A. (2013). Heparin Promotes the Rapid Fibrillization of a Peptide with Low Intrinsic Amyloidogenicity. BIOCHEMISTRY, 52(50), 8984-8992. doi:10.1021/bi401231u
2012
Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks
Madine, J., Davies, H. A., Shaw, C., Hamley, I. W., & Middleton, D. A. (2012). Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks. CHEMICAL COMMUNICATIONS, 48(24), 2976-2978. doi:10.1039/c2cc17118j
Solid-state NMR reveals differences in the packing arrangements of peptide aggregates derived from the aortic amyloid polypeptide medin
Davies, H. A., Madine, J., & Middleton, D. A. (2012). Solid-state NMR reveals differences in the packing arrangements of peptide aggregates derived from the aortic amyloid polypeptide medin. JOURNAL OF PEPTIDE SCIENCE, 18(1), 65-72. doi:10.1002/psc.1418
Undated
Expression and characterisation of cardiovascular amyloid proteins
Davies, H. (n.d.). Expression and characterisation of cardiovascular amyloid proteins. (PhD Thesis, University of Liverpool).