Publications
2024
P.028: Optimisation of donation after circulatory death livers – removal of extracellular histones during normothermic perfusion and following whole blood reperfusion in an ex-situ porcine model.
Hussain Abbas, S., Dengu, F., Schofield, J., Wang, G., Morovat, A., Quaglia, A., . . . Friend, P. (2024). P.028: Optimisation of donation after circulatory death livers – removal of extracellular histones during normothermic perfusion and following whole blood reperfusion in an ex-situ porcine model.. Transplantation, 108(9S). doi:10.1097/01.tp.0001067024.19971.ae
Fibrinogen binding to histones in circulation protects against adverse cellular and clinical outcomes.
Toh, J. M., Yong, J., Abrams, S. T., Wang, L., Schofield, J., Lane, S., . . . Toh, C. -H. (2024). Fibrinogen binding to histones in circulation protects against adverse cellular and clinical outcomes.. Journal of thrombosis and haemostasis : JTH, 22(8), 2247-2260. doi:10.1016/j.jtha.2024.05.009
Restoring discarded porcine lungs by ex vivo removal of neutrophil extracellular traps.
Mittendorfer, M., Pierre, L., Huzevka, T., Schofield, J., Abrams, S. T., Wang, G., . . . Lindstedt, S. (2024). Restoring discarded porcine lungs by ex vivo removal of neutrophil extracellular traps.. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, S1053-2498(24)01736-4. doi:10.1016/j.healun.2024.07.007
Are NETs a Novel, Exciting, Thrombosis Risk Marker?
Wang, G., Abrams, S. T., & Toh, C. -H. (2024). Are NETs a Novel, Exciting, Thrombosis Risk Marker?. Thrombosis and haemostasis, 124(5), 455-458. doi:10.1055/a-2187-0645
Amyloid-Fibrinogen Aggregates ("Microclots") Predict Risks of Disseminated Intravascular Coagulation and Mortality.
Schofield, J., Abrams, S. T., Jenkins, R., Lane, S., Wang, G., & Toh, C. -H. (2024). Amyloid-Fibrinogen Aggregates ("Microclots") Predict Risks of Disseminated Intravascular Coagulation and Mortality.. Blood advances, bloodadvances.2023012473. doi:10.1182/bloodadvances.2023012473
2023
Immune dysregulation in sepsis: experiences, lessons and perspectives.
Cao, M., Wang, G., & Xie, J. (2023). Immune dysregulation in sepsis: experiences, lessons and perspectives.. Cell death discovery, 9(1), 465. doi:10.1038/s41420-023-01766-7
Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia.
Abrams, S. T., Du, M., Shaw, R. J., Johnson, C., McGuinness, D., Schofield, J., . . . Toh, C. -H. (2023). Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia.. Journal of thrombosis and haemostasis : JTH, S1538-7836(23)00873-5. doi:10.1016/j.jtha.2023.12.008
Development of genomic phenotype and immunophenotype of acute respiratory distress syndrome using autophagy and metabolism-related genes.
Xia, F., Chen, H., Liu, Y., Huang, L., Meng, S., Xu, J., . . . Guo, F. (2023). Development of genomic phenotype and immunophenotype of acute respiratory distress syndrome using autophagy and metabolism-related genes.. Frontiers in immunology, 14, 1209959. doi:10.3389/fimmu.2023.1209959
OC 78.5 Systemic Snakebite Envenoming Causes Histone-Induced Thrombocytopaenia
Schofield, J., Abrams, S., Alhamdi, Y., Ainsworth, S., Evans, C., Albulescu, L., . . . Toh, C. (2023). OC 78.5 Systemic Snakebite Envenoming Causes Histone-Induced Thrombocytopaenia. Research and Practice in Thrombosis and Haemostasis, 7, 100487. doi:10.1016/j.rpth.2023.100487
PB0794 Fibrinogen Protects against Histone-Induced Thrombocytopaenia
Yong, J., Abrams, S., Alhamdi, Y., Wang, G., & Toh, C. (2023). PB0794 Fibrinogen Protects against Histone-Induced Thrombocytopaenia. Research and Practice in Thrombosis and Haemostasis, 7, 101370. doi:10.1016/j.rpth.2023.101370
Targeted Destruction of S100A4 Inhibits Metastasis of Triple Negative Breast Cancer Cells
Ismail, T. M., Crick, R. G., Du, M., Shivkumar, U., Carnell, A., Barraclough, R., . . . Rudland, P. S. (2023). Targeted Destruction of S100A4 Inhibits Metastasis of Triple Negative Breast Cancer Cells. BIOMOLECULES, 13(7). doi:10.3390/biom13071099
Cell-free histones and the cell-based model of coagulation.
Yong, J., Abrams, S. T., Wang, G., & Toh, C. -H. (2023). Cell-free histones and the cell-based model of coagulation.. Journal of thrombosis and haemostasis : JTH, S1538-7836(23)00340-9. doi:10.1016/j.jtha.2023.04.018
Neutrophil Extracellular Traps Removal During Ex Vivo Lung Perfusion Improves Lung Function in Aspiration Damaged Porcine Lungs
Mittendorfer, M., Pierre, L., Kjellberg, G., Schofield, J., Abrams, S., Wang, G., . . . Lindstedt, S. (2023). Neutrophil Extracellular Traps Removal During Ex Vivo Lung Perfusion Improves Lung Function in Aspiration Damaged Porcine Lungs. In JOURNAL OF HEART AND LUNG TRANSPLANTATION Vol. 42 (pp. S115). Retrieved from https://www.webofscience.com/
Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis
Abrams, S. T. T., Alhamdi, Y., Zi, M., Guo, F., Du, M., Wang, G., . . . Toh, C. -H. (2023). Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(4). doi:10.3390/ijms24043225
Systemic snakebite envenoming causes histone-induced thrombocytopaenia
Schofield, J., Abrams, S., Alhamdi, Y., Ainsworth, S., Evans, C., Albulescu, L. -O., . . . Toh, C. -H. (2023). Systemic snakebite envenoming causes histone-induced thrombocytopaenia. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 201 (pp. 52-53). Retrieved from https://www.webofscience.com/
2022
The Importance of Pore-Forming Toxins in Multiple Organ Injury and Dysfunction
Abrams, S. T. T., Wang, L., Yong, J., Yu, Q., Du, M., Alhamdi, Y., . . . Wang, G. (2022). The Importance of Pore-Forming Toxins in Multiple Organ Injury and Dysfunction. BIOMEDICINES, 10(12). doi:10.3390/biomedicines10123256
The aetiopathogenesis of vaccine-induced immune thrombotic thrombocytopenia
Toh, C. -H., Wang, G., & Parker, A. L. (2022). The aetiopathogenesis of vaccine-induced immune thrombotic thrombocytopenia. CLINICAL MEDICINE, 22(2), 140-144. doi:10.7861/clinmed.2022-0006
Extracellular histones cause intestinal epithelium injury and disrupt its barrier function in vitro and in vivo.
Chen, C., Lin, Z., Zhang, X., Zhang, X., Cheng, Z., Jin, T., . . . Xia, Q. (2022). Extracellular histones cause intestinal epithelium injury and disrupt its barrier function in vitro and in vivo.. Toxicology, 469, 153117. doi:10.1016/j.tox.2022.153117
Reduction of NETosis by targeting CXCR1/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsis
Alsabani, M., Abrams, S. T., Cheng, Z., Morton, B., Lane, S., Alosaimi, S., . . . Toh, C. -H. (2022). Reduction of NETosis by targeting CXCR1/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsis. British Journal of Anaesthesia, 128(2), 283-293. doi:10.1016/j.bja.2021.10.039
2021
Circulating histones play a central role in COVID-19-associated coagulopathy and mortality
Shaw, R. J., Abrams, S. T., Austin, J., Taylor, J. M., Lane, S., Dutt, T., . . . Toh, C. -H. (2021). Circulating histones play a central role in COVID-19-associated coagulopathy and mortality. HAEMATOLOGICA, 106(9), 2493-2498. doi:10.3324/haematol.2021.278492
COVID-19 and immunothrombosis: emerging understanding and clinical management
Shaw, R. J., Bradbury, C., Abrams, S. T., Wang, G., & Toh, C. -H. (2021). COVID-19 and immunothrombosis: emerging understanding and clinical management. BRITISH JOURNAL OF HAEMATOLOGY, 194(3), 518-529. doi:10.1111/bjh.17664
Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation
Abrams, S. T., Su, D., Sahraoui, Y., Lin, Z., Cheng, Z., Nesbitt, K., . . . Toh, C. -H. (2021). Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation. BLOOD, 137(1), 103-114. doi:10.1182/blood.2019002973
2020
Extracellular histones stimulate collagen expression <i>in vitro</i> and promote liver fibrogenesis in a mouse model <i>via </i>the TLR4-MyD88 signaling pathway
Wang, Z., Cheng, Z. -X., Abrams, S. T., Lin, Z. -Q., Yates, E. D., Yu, Q., . . . Wang, G. -Z. (2020). Extracellular histones stimulate collagen expression <i>in vitro</i> and promote liver fibrogenesis in a mouse model <i>via </i>the TLR4-MyD88 signaling pathway. WORLD JOURNAL OF GASTROENTEROLOGY, 26(47), 7513-7527. doi:10.3748/wjg.v26.i47.7513
Circulating Histone Levels Correlate with the Severity of COVID-19 and the Extent of Coagulation Activation and Inflammation
Shaw, R. J., Austin, J., Taylor, J., Dutt, T., Wang, G., Abrams, S. T., & Toh, C. H. (2020). Circulating Histone Levels Correlate with the Severity of COVID-19 and the Extent of Coagulation Activation and Inflammation. In BLOOD Vol. 136. doi:10.1182/blood-2020-142344
Extracellular histones stimulate collagen expression and potentially promote liver fibrogenesis via TLR4-MyD88 signalling pathway
The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development
Cheng, Z., Abrams, S. T., Austin, J., Toh, J., Wang, S. S., Wang, Z., . . . Wang, G. (2020). The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development. MEDIATORS OF INFLAMMATION, 2020. doi:10.1155/2020/7418342
The Critical Roles and Mechanisms of Immune Cell Death in Sepsis
Cheng, Z., Abrams, S. T., Toh, J., Wang, S. S., Wang, Z., Yu, Q., . . . Wang, G. (2020). The Critical Roles and Mechanisms of Immune Cell Death in Sepsis. FRONTIERS IN IMMUNOLOGY, 11. doi:10.3389/fimmu.2020.01918
Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria
Moxon, C. A., Alhamdi, Y., Storm, J., Toh, J. M. H., McGuinness, D., Ko, J. Y., . . . Toh, C. (n.d.). Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria. Blood Advances, 4(13), 2851-2864. doi:10.1182/bloodadvances.2019001258
Complexes between C-Reactive Protein and Very Low Density Lipoprotein Delay Bacterial Clearance in Sepsis
Cheng, Z., Abrams, S. T., Toh, J., Wang, S. S., Downey, C., Ge, X., . . . Toh, C. -H. (2020). Complexes between C-Reactive Protein and Very Low Density Lipoprotein Delay Bacterial Clearance in Sepsis. Journal of Immunology, 204(10), 2712-2721. doi:10.4049/jimmunol.1900962
Parasite histones mediate blood-brain barrier disruption in cerebral malaria.
Moxon, C., Alhamdi, Y., Storm, J., Toh, J., Ko, J. Y., Murphy, G., . . . Toh, C. -H. (2020). Parasite histones mediate blood-brain barrier disruption in cerebral malaria.. Clinical medicine (London, England), 20(Suppl 2), s96-s97. doi:10.7861/clinmed.20-2-s96
Direct interaction of metastasis-inducing S100P protein with tubulin causes enhanced cell migration without changes in cell adhesion
Du, M., Wang, G., Barsukov, I. L., Gross, S. R., Smith, R., & Rudland, P. S. (2020). Direct interaction of metastasis-inducing S100P protein with tubulin causes enhanced cell migration without changes in cell adhesion. BIOCHEMICAL JOURNAL, 477(6), 1159-1178. doi:10.1042/BCJ20190644
A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit.
Abrams, S., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2020). A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit.. Clinical medicine (London, England), 20(Suppl 2), s114-s115. doi:10.7861/clinmed.20-2-s114
2019
A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies
Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2019). A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies. In BLOOD Vol. 134. doi:10.1182/blood-2019-128493
A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients
Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M., Lane, S., Welters, I. D., . . . Toh, C. -H. (2019). A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients. American journal of respiratory and critical care medicine, 200(07), 869-880. doi:10.1164/rccm.201811-2111oc
Circulating Histones Are Major Mediators of Multiple Organ Dysfunction Syndrome in Acute Critical Illnesses.
Cheng, Z., Abrams, S. T., Alhamdi, Y., Toh, J., Yu, W., Wang, G., & Toh, C. -H. (2019). Circulating Histones Are Major Mediators of Multiple Organ Dysfunction Syndrome in Acute Critical Illnesses.. Critical care medicine, 47(8), e677-e684. doi:10.1097/ccm.0000000000003839
Parasite histones mediate leak and coagulopathy in cerebral malaria
Parasite histones are associated with poor outcome in cerebral malaria
Moxon, C., Alhamdi, Y., Storm, J., Toh, J., Ko, J. Y., Murphy, G., . . . Toh, C. -H. (2019). Parasite histones are associated with poor outcome in cerebral malaria. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 185 (pp. 33). Retrieved from https://www.webofscience.com/
2018
Histones Bind Prothrombin to Generate Alternative Prothrombinase Complexes That Can Disseminate Intravascular Coagulation
Abrams, S. T., Su, D., Sahraoui, Y., Alhamdi, Y., Wang, G., & Toh, C. H. (2018). Histones Bind Prothrombin to Generate Alternative Prothrombinase Complexes That Can Disseminate Intravascular Coagulation. In BLOOD Vol. 132. doi:10.1182/blood-2018-99-116117
Proteolysis-targeting chimera (PROTAC) compounds to degrade S100A4 and inhibit breast cancer metastasis
Du, M., Wang, G., Ismail, T. M., Crick, R., Barraclough, R., Daimark, B. H., . . . Rudland, P. (2018). Proteolysis-targeting chimera (PROTAC) compounds to degrade S100A4 and inhibit breast cancer metastasis. In ANNALS OF ONCOLOGY Vol. 29. Retrieved from https://www.webofscience.com/
Extracellular Histones Inhibit Complement Activation through Interacting with Complement Component 4
Qaddoori, Y., Abrams, S. T., Mould, P., Alhamdi, Y., Christmas, S. E., Wang, G., & Toh, C. -H. (2018). Extracellular Histones Inhibit Complement Activation through Interacting with Complement Component 4. JOURNAL OF IMMUNOLOGY, 200(12), 4125-4133. doi:10.4049/jimmunol.1700779
2017
Systemic histone release disrupts plasmalemma and contributes to necrosis in acute pancreatitis
Szatmary, P., Liu, T., Abrams, S. T., Voronina, S., Wen, L., Chvanov, M., . . . Sutton, R. (2017). Systemic histone release disrupts plasmalemma and contributes to necrosis in acute pancreatitis. PANCREATOLOGY, 17(6), 884-892. doi:10.1016/j.pan.2017.10.002
Extracellular histones inhibit complement activation through interactions with complement component C4b
Qaddoori, Y., Abrams, S. T., Su, D., Liu, T., Alhamdi, Y., Wang, G., & Toh, C. -H. (2017). Extracellular histones inhibit complement activation through interactions with complement component C4b. In MOLECULAR IMMUNOLOGY Vol. 89 (pp. 132). doi:10.1016/j.molimm.2017.06.067
Accuracy of circulating histones in predicting persistent organ failure and mortality in patients with acute pancreatitis
Liu, T., Huang, W., Szatmary, P., Abrams, S. T., Alhamdi, Y., Lin, Z., . . . Toh, C. H. (2017). Accuracy of circulating histones in predicting persistent organ failure and mortality in patients with acute pancreatitis. BRITISH JOURNAL OF SURGERY, 104(9), 1215-1225. doi:10.1002/bjs.10538
Circulating histones associate with severity and play important roles in acute pancreatitis
Lin, Z., Cheng, Z., Liu, T., Wang, G., Sutton, R., & Toh, C. -H. (2017). Circulating histones associate with severity and play important roles in acute pancreatitis. Pancreatology, 17(3), S33. doi:10.1016/j.pan.2017.05.102
143 The roles and mechanisms of pore-forming toxins in cardiac injury
Wang, G., Alhamdi, Y., & Toh, C. -H. (2017). 143 The roles and mechanisms of pore-forming toxins in cardiac injury. Heart, 103(Suppl 5), A107.1-A107. doi:10.1136/heartjnl-2017-311726.142
Elevated Circulating Histones Associate With Multiple Organ Dysfunction Syndromes in Acute Pancreatitis
Liu, T., Huang, W., Abrams, S., Wang, L., Szatmary, P., Alhamdi, Y., . . . Sutton, R. (2016). Elevated Circulating Histones Associate With Multiple Organ Dysfunction Syndromes in Acute Pancreatitis. PANCREAS, 45(10), 1520. Retrieved from https://www.webofscience.com/
THE ROLES AND MECHANISMS OF PORE-FORMING TOXINS IN CARDIAC INJURY
Wang, G., Alhamdi, Y., & Toh, C. -H. (2017). THE ROLES AND MECHANISMS OF PORE-FORMING TOXINS IN CARDIAC INJURY. In HEART Vol. 103 (pp. A107). Retrieved from https://www.webofscience.com/
2016
Feasibility Study of Using the Housing Cases of Implantable Devices as Antennas
Kod, M., Zhou, J., Huang, Y., Stanley, M., Hussein, M., Sohrab, A. P., . . . Wang, G. (2016). Feasibility Study of Using the Housing Cases of Implantable Devices as Antennas. IEEE Access, 4, 6939-6949. doi:10.1109/ACCESS.2016.2613968
Circulating histones accurately predict persistent organ failure and mortality in patients with acute pancreatitis within 24 h of admission
Liu, T., Huang, W., Szatmary, P., Abrams, S., Alhamdi, Y., Lin, Z., . . . Toh, C. -H. (2016). Circulating histones accurately predict persistent organ failure and mortality in patients with acute pancreatitis within 24 h of admission. Pancreatology, 16(3), S100-S101. doi:10.1016/j.pan.2016.05.338
Circulating Histone Concentrations Differentially Affect the Predominance of Left or Right Ventricular Dysfunction in Critical Illness
Alhamdi, Y., Zi, M., Abrams, S., Liu, T., Su, D., Welters, I., . . . Toh, C. -H. (2016). Circulating Histone Concentrations Differentially Affect the Predominance of Left or Right Ventricular Dysfunction in Critical Illness. Critical Care Medicine, 44(05), e278-e288. doi:10.1097/CCM.0000000000001413
Histone-Associated Thrombocytopenia in Patients Who Are Critically Ill
Alhamdi, Y., Abrams, S., Lane, S., Wang, G., & Toh, C. -H. (2016). Histone-Associated Thrombocytopenia in Patients Who Are Critically Ill. JAMA: Journal of the American Medical Association, 315(8), 817-819. doi:10.1001/jama.2016.0136
EXTRACELLULAR HISTONES ENHANCE FACTOR XA MEDIATED PROTHROMBIN ACTIVATION WITHOUT PHOSPHOLIPID REQUIREMENT
Sahraoui, Y., Abrams, S., Su, D., Alhamdi, Y., Foley, J., Wang, G., & Toh, C. H. (2016). EXTRACELLULAR HISTONES ENHANCE FACTOR XA MEDIATED PROTHROMBIN ACTIVATION WITHOUT PHOSPHOLIPID REQUIREMENT. In HAEMATOLOGICA Vol. 101 (pp. 310). Retrieved from https://www.webofscience.com/
Early prediction of major clinical outcomes of patients with acute pancreatitis by circulating histones
Liu, T., Huang, W., Szatmary, P., Abrams, S. T., Greenhalf, W., Welters, I., . . . Toh, C. H. (2016). Early prediction of major clinical outcomes of patients with acute pancreatitis by circulating histones. Pancreatology, 16(1), S34. doi:10.1016/j.pan.2015.12.107
Extracellular histones promote prothrombin activation in the absence of phospholipids
Sahraoui, Y., Abrams, S. T., Su, D., Alhamdi, Y., Foley, J., Wang, G., & Toh, C. H. (2016). Extracellular histones promote prothrombin activation in the absence of phospholipids. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 173 (pp. 19). Retrieved from https://www.webofscience.com/
Histone-associated thrombocytopaenia is a significant cause of thrombocytopaenia in critical illness
Alhamdi, Y., Abrams, S. T., Lane, S., Wang, G., & Toh, C. H. (2016). Histone-associated thrombocytopaenia is a significant cause of thrombocytopaenia in critical illness. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 173 (pp. 19). Retrieved from https://www.webofscience.com/
2015
Carbon Monoxide-Releasing Molecule-2 Reduces Intestinal Epithelial Tight-Junction Damage and Mortality in Septic Rats
Zhang, S., Zheng, S., Wang, X., Shi, Q., Wang, X., Yuan, S., . . . Ji, Z. (2015). Carbon Monoxide-Releasing Molecule-2 Reduces Intestinal Epithelial Tight-Junction Damage and Mortality in Septic Rats. PLOS ONE, 10(12). doi:10.1371/journal.pone.0145988
Visualizing myocardial inflammation in a rat model of type 4 cardiorenal syndrome by dual-modality molecular imaging.
Chang, D., Wang, Y. -C., Zhang, S. -J., Bai, Y. -Y., Liu, D. -F., Zang, F. -C., . . . Ju, S. (2015). Visualizing myocardial inflammation in a rat model of type 4 cardiorenal syndrome by dual-modality molecular imaging.. Biomaterials, 68, 67-76. doi:10.1016/j.biomaterials.2015.07.050
Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis
Ou, X., Cheng, Z., Liu, T., Tang, Z., Huang, W., Szatmary, P., . . . Wang, G. (2015). Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis. Pancreas, 44(7), 1089-1095. doi:10.1097/MPA.0000000000000416
Circulating histones are major mediators of cardiac injury in patients with sepsis
Alhamdi, Y., Abrams, S. T., Cheng, Z., Jing, S., Su, D., Liu, Z., . . . Toh,, C. -H. (2015). Circulating histones are major mediators of cardiac injury in patients with sepsis. Critical Care Medicine, 43(10), 2094-2103. doi:10.1097/CCM.0000000000001162
Synergistic Effects of Transplanted Endothelial Progenitor Cells and RWJ 67657 in Diabetic Ischemic Stroke Models
Bai, Y. -Y., Wang, L., Chang, D., Zhao, Z., Lu, C. -Q., Wang, G., & Ju, S. (2015). Synergistic Effects of Transplanted Endothelial Progenitor Cells and RWJ 67657 in Diabetic Ischemic Stroke Models. STROKE, 46(7), 1938-1946. doi:10.1161/STROKEAHA.114.008495
S100P REGULATES CYTOSKELETON DYNAMICS TO PROMOTE CELL MIGRATION AND METASTASIS
Du, M., Wang, G., Barraclough, R., & Rudland, P. (2015). S100P REGULATES CYTOSKELETON DYNAMICS TO PROMOTE CELL MIGRATION AND METASTASIS. In EUROPEAN JOURNAL OF CANCER Vol. 51 (pp. E6-E7). doi:10.1016/j.ejca.2015.06.022
Circulating histones contribute to acute respiratory distress syndrome in acute pancreatitis
Liu, T., Abrams, S., Szatmary, P., Cheng, Z., Huang, W., Ou, X., . . . Toh, C. -H. (2015). Circulating histones contribute to acute respiratory distress syndrome in acute pancreatitis. Pancreatology, 15(3), S63. doi:10.1016/j.pan.2015.05.242
Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection
Alhamdi, Y., Neill, D., Abrams, S., Malak, H., Yahya, R., Barrett-Jolley, R., . . . Toh, C. -H. (2015). Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection. PLoS Pathogens, 11(5). doi:10.1371/journal.ppat.1004836
Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis
Ou, X., Cheng, Z., Liu, T., Tang, Z., Huang, W., Szatmary, P., . . . Wang, G. (2015). Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis.
Circulating Histones Target Acinar Cells and Exacerbate Injury in Experimental Acute Pancreatitis
Szatmary, P., Liu, T., Abrams, S., Wen, L., Huang, W., Wang, G., . . . Sutton, R. (2015). Circulating Histones Target Acinar Cells and Exacerbate Injury in Experimental Acute Pancreatitis. PANCREAS, 44(8), 1418. Retrieved from https://www.webofscience.com/
Circulating histones disturb intracellular calcium homeostasis and cause calcium overload to induce cardiovascular abnormalities in sepsis
Alhamdi, Y., Abrams, S. T., Zi, M., Welters, I., Cartwright, E. J., Wang, G., & Toh, C. -H. (2015). Circulating histones disturb intracellular calcium homeostasis and cause calcium overload to induce cardiovascular abnormalities in sepsis. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13, 159. Retrieved from https://www.webofscience.com/
Early Prediction of Major Clinical Outcomes of Patients With Acute Pancreatitis by Circulating Histones
Liu, T., Huang, W., Szatmary, P., Abrams, S. T., Greenhalf, W., Welters, I., . . . Toh, C. H. (2015). Early Prediction of Major Clinical Outcomes of Patients With Acute Pancreatitis by Circulating Histones. PANCREAS, 44(8), 1393. Retrieved from https://www.webofscience.com/
Histone-associated thrombocytopenia: a new cause of thrombocytopenia in critically ill patients
Alhamdi, Y., Abrams, S. T., Welters, I., Wang, G., & Toh, C. -H. (2015). Histone-associated thrombocytopenia: a new cause of thrombocytopenia in critically ill patients. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13, 94. Retrieved from https://www.webofscience.com/
2014
Protective Effects of Carbon Monoxide-Releasing Molecule-2 on the Barrier Function of Intestinal Epithelial Cells
Mu, X., Pan, C., Zheng, S., Alhamdi, Y., Sun, B., Shi, Q., . . . Wang, G. (2014). Protective Effects of Carbon Monoxide-Releasing Molecule-2 on the Barrier Function of Intestinal Epithelial Cells. PLOS ONE, 9(8). doi:10.1371/journal.pone.0104032
The Role of Neutrophil Extracellular Traps in Acute Pancreatitis
Szatmary, P., Liu, T., Wen, L., Huang, W., Awais, M., Wang, G., . . . Sutton, R. (2014). The Role of Neutrophil Extracellular Traps in Acute Pancreatitis. PANCREAS, 43(8), 1413. Retrieved from https://www.webofscience.com/
Use of Citrullinated Histones and Circulating Nucleosomes in Early Prediction of Organ Failure in Acute Pancreatitis
Szatmary, P., Liu, T., Huang, W., Wang, G., Latawiec, D., Davies, K., . . . Sutton, R. (2014). Use of Citrullinated Histones and Circulating Nucleosomes in Early Prediction of Organ Failure in Acute Pancreatitis. PANCREAS, 43(8), 1413. Retrieved from https://www.webofscience.com/
2013
Histone-Induced Lung Injury and Coagulation Activation Are Reduced By C-Reactive Protein In The Acute Phase Response
Abrams, S. T., Zhang, N., Wang, G., & Toh, C. -H. (2013). Histone-Induced Lung Injury and Coagulation Activation Are Reduced By C-Reactive Protein In The Acute Phase Response. In BLOOD Vol. 122. doi:10.1182/blood.V122.21.457.457
Human CRP Defends against the Toxicity of Circulating Histones
Abrams, S. T., Zhang, N., Dart, C., Wang, S. S., Thachil, J., Guan, Y., . . . Toh, C. -H. (2013). Human CRP Defends against the Toxicity of Circulating Histones. JOURNAL OF IMMUNOLOGY, 191(5), 2495-2502. doi:10.4049/jimmunol.1203181
Circulating Histones Are Mediators of Trauma-associated Lung Injury
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Activated protein C (APC) and thrombin modulate cardiomyocytes contractility via a protease activated receptor-1 (PAR1)-cardiac troponin I (CTI) pathway
Alhamdi, Y., Wang, G., & Toh, C. -H. (2013). Activated protein C (APC) and thrombin modulate cardiomyocytes contractility via a protease activated receptor-1 (PAR1)-cardiac troponin I (CTI) pathway. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 38). Retrieved from https://www.webofscience.com/
Acute phase proteins reduce histone-induced platelet aggregation and coagulation activation
Abrams, S. T., Manson, J., Liu, T., Baluwa, F., Barrera, V., Brohi, K., . . . Toh, C. H. (2013). Acute phase proteins reduce histone-induced platelet aggregation and coagulation activation. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 22). Retrieved from https://www.webofscience.com/
Circulating histone-induced thrombosis leads to circulatory and respiratory failure
Abrams, S. T., Manson, J., Liu, T., Alhamdi, Y., Brohi, K., Wang, G., & Toh, C. H. (2013). Circulating histone-induced thrombosis leads to circulatory and respiratory failure. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 128). Retrieved from https://www.webofscience.com/
Platelet surface high mobility group box protein-1 binds receptor for advanced glycation endproducts in plasma or on monocytes in septic patients
Thachil, J., Barrera, V., Djebabri, B., Abrams, S. T., Wang, G., & Toh, C. H. (2013). Platelet surface high mobility group box protein-1 binds receptor for advanced glycation endproducts in plasma or on monocytes in septic patients. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 71). Retrieved from https://www.webofscience.com/
The involvement of epigenetic silencing of Foxa2 in cellular replicative and premature senescence induced by hydrogen peroxide.
Zhang, W., Ji, W., Yang, L., Yao, L., Wang, G., Xuan, A., & Zhuang, Z. (2013). The involvement of epigenetic silencing of Foxa2 in cellular replicative and premature senescence induced by hydrogen peroxide.. Free radical research, 47(4), 325-332. doi:10.3109/10715762.2013.773589
2012
S100P Dissociates Myosin IIA Filaments and Focal Adhesion Sites to Reduce Cell Adhesion and Enhance Cell Migration
Du, M., Wang, G., Ismail, T. M., Gross, S., Fernig, D. G., Barraclough, R., & Rudland, P. S. (2012). S100P Dissociates Myosin IIA Filaments and Focal Adhesion Sites to Reduce Cell Adhesion and Enhance Cell Migration. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(19), 15330-15344. doi:10.1074/jbc.M112.349787
2011
Reduction of circulating histone toxicity is a major function of C-reactive protein after extensive tissue damage
2010
Self-association of Calcium-binding Protein S100A4 and Metastasis
Ismail, T. M., Zhang, S., Fernig, D. G., Gross, S., Martin-Fernandez, M. L., See, V., . . . Barraclough, R. (2010). Self-association of Calcium-binding Protein S100A4 and Metastasis. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(2), 914-922. doi:10.1074/jbc.M109.010892
2008
The basic C-terminal amino acids of calcium-binding protein S100A4 promote metastasis
Ismail, T. M., Fernig, D. G., Rudland, P. S., Terry, C. J., Wang, G., & Barraclough, R. (2008). The basic C-terminal amino acids of calcium-binding protein S100A4 promote metastasis. CARCINOGENESIS, 29(12), 2259-2266. doi:10.1093/carcin/bgn217
HP1-beta is required for development of the cerebral neocortex and neuromuscular junctions.
Aucott, R., Bullwinkel, J., Yu, Y., Shi, W., Billur, M., Brown, J. P., . . . Singh, P. B. (2008). HP1-beta is required for development of the cerebral neocortex and neuromuscular junctions.. The Journal of cell biology, 183(4), 597-606. doi:10.1083/jcb.200804041
2006
Induction of metastasis by S100P in a rat mammary model and its association with poor survival of breast cancer patients
Wang, G. Z., Platt-Higgins, A., Carroll, J., Rudland, S. D., Winstanley, J., Barraclough, R., & Rudland, P. S. (2006). Induction of metastasis by S100P in a rat mammary model and its association with poor survival of breast cancer patients. CANCER RESEARCH, 66(2), 1199-1207. doi:10.1158/0008-5472.CAN-05-2605
2005
The <i>C</i>-terminal region of S100A4 is important for its metastasis-inducing properties
Zhang, S., Wang, G. Z., Liu, D., Bao, Z. Z., Fernig, D. G., Rudland, P. S., & Barraclough, R. (2005). The <i>C</i>-terminal region of S100A4 is important for its metastasis-inducing properties. ONCOGENE, 24(27), 4401-4411. doi:10.1038/sj.onc.1208663
Mutually antagonistic actions of S100A4 and S100A1 on normal and metastatic phenotypes
Wang, G. Z., Zhang, S., Fernig, D. G., Martin-Fernandez, M., Rudland, P. S., & Barraclough, R. (2005). Mutually antagonistic actions of S100A4 and S100A1 on normal and metastatic phenotypes. ONCOGENE, 24(8), 1445-1454. doi:10.1038/sj.onc.1208291
Interaction of metastasis-inducing S100A4 protein in vivo by fluorescence lifetime imaging microscopy
Zhang, S., Wang, G. Z., Fernig, D. G., Rudland, P. S., Webb, S. E. D., Barraclough, R., & Martin-Fernandez, M. (2005). Interaction of metastasis-inducing S100A4 protein in vivo by fluorescence lifetime imaging microscopy. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 34(1), 19-27. doi:10.1007/s00249-004-0428-x
2004
Heterodimeric interaction and interfaces of S100A1 and S100P
Wang, G. Z., Zhang, S., Fernig, D. G., Spiller, D., Martin-Fernandez, M., Zhang, H. M., . . . Barraclough, R. (2004). Heterodimeric interaction and interfaces of S100A1 and S100P. BIOCHEMICAL JOURNAL, 382, 375-383. doi:10.1042/BJ20040142
2003
Purification, crystallization and preliminary X-ray analysis of human pirin.
Zeng, Q., Li, X., Bartlam, M., Wang, G., Pang, H., & Rao, Z. (2003). Purification, crystallization and preliminary X-ray analysis of human pirin.. Acta crystallographica. Section D, Biological crystallography, 59(Pt 8), 1496-1498. doi:10.1107/s0907444903012289
The crystal structure at 2 Å resolution of the Ca<SUP>2+</SUP>-binding protein S100P
Zhang, H. M., Wang, G. Z., Ding, Y., Wang, Z. L., Barraclough, R., Rudland, P. S., . . . Rao, Z. H. (2003). The crystal structure at 2 Å resolution of the Ca<SUP>2+</SUP>-binding protein S100P. JOURNAL OF MOLECULAR BIOLOGY, 325(4), 785-794. doi:10.1016/S0022-2836(02)01278-0
2002
Purification, crystallization and preliminary X-ray diffraction studies of a Ca<SUP>2+</SUP>-binding protein, human S100P
Zhang, H. M., Wang, Z. L., Ding, Y., Wang, G. Z., Wang, X. D., Gao, F., . . . Rao, Z. H. (2002). Purification, crystallization and preliminary X-ray diffraction studies of a Ca<SUP>2+</SUP>-binding protein, human S100P. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 58, 694-696. doi:10.1107/S0907444902002342
Crystallization and preliminary crystallographic analysis of a metastasis-inducing protein, human S100A4
Zhang, H. M., Wang, Z. L., Ding, Y., Wang, G. Z., Wang, X. D., Bartlam, M., . . . Rao, Z. H. (2002). Crystallization and preliminary crystallographic analysis of a metastasis-inducing protein, human S100A4. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 58, 127-129. doi:10.1107/S090744490101650X
2001
Preliminary X-ray crystallographic analysis of a Ca<SUP>2+</SUP>-binding protein human S100A1
Wang, Z. L., Zhang, H. M., Ding, Y., Wang, G. Z., Wang, X. D., Ye, S., . . . Rao, Z. H. (2001). Preliminary X-ray crystallographic analysis of a Ca<SUP>2+</SUP>-binding protein human S100A1. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 57, 882-883. doi:10.1107/S0907444901005273
2000
Conservation of heterochromatin protein 1 function.
Wang, G., Ma, A., Chow, C. M., Horsley, D., Brown, N. R., Cowell, I. G., & Singh, P. B. (2000). Conservation of heterochromatin protein 1 function.. Molecular and cellular biology, 20(18), 6970-6983. doi:10.1128/mcb.20.18.6970-6983.2000
Interaction <i>in vivo</i> and <i>in vitro</i> of the metastasis-inducing S100 protein, S100A4 (p9Ka) with S100A1
Wang, G. Z., Rudland, P. S., White, M. R., & Barraclough, R. (2000). Interaction <i>in vivo</i> and <i>in vitro</i> of the metastasis-inducing S100 protein, S100A4 (p9Ka) with S100A1. JOURNAL OF BIOLOGICAL CHEMISTRY, 275(15), 11141-11146. doi:10.1074/jbc.275.15.11141
1998
The M31 gene has a complex developmentally regulated expression profile and may encode alternative protein products that possess diverse subcellular localisation patterns.
Peterson, K., Wang, G., Horsley, D., Richardson, J. C., Sapienza, C., Latham, K. E., & Singh, P. B. (1998). The M31 gene has a complex developmentally regulated expression profile and may encode alternative protein products that possess diverse subcellular localisation patterns.. The Journal of experimental zoology, 280(4), 288-303. doi:3.0.co;2-k">10.1002/(sici)1097-010x(19980301)280:4<288::aid-jez3>3.0.co;2-k
1997
M33, a mammalian homologue of Drosophila Polycomb localises to euchromatin within interphase nuclei but is enriched within the centromeric heterochromatin of metaphase chromosomes.
Wang, G., Horsley, D., Ma, A., Otte, A. P., Hutchings, A., Butcher, G. W., & Singh, P. B. (1997). M33, a mammalian homologue of Drosophila Polycomb localises to euchromatin within interphase nuclei but is enriched within the centromeric heterochromatin of metaphase chromosomes.. Cytogenetics and cell genetics, 78(1), 50-55. doi:10.1159/000134626