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2024

Efficacy and safety of higher dose rifampicin in adults with presumed drug-susceptible tuberculosis: an updated systematic review and meta-analysis.

Haigh, K. A., Twabi, H. H., Boloko, L., Namale, P. E., Lutje, V., Nevitt, S., & Davies, G. (2024). Efficacy and safety of higher dose rifampicin in adults with presumed drug-susceptible tuberculosis: an updated systematic review and meta-analysis.. EClinicalMedicine, 77, 102857. doi:10.1016/j.eclinm.2024.102857

DOI
10.1016/j.eclinm.2024.102857
Journal article

Multi-drug Resistant Tuberculosis in Travellers

Davies, G. R. (2024). Multi-drug Resistant Tuberculosis in Travellers. In Emerging and Re-emerging Infections in Travellers (pp. 331-342). Springer International Publishing. doi:10.1007/978-3-031-49475-8_21

DOI
10.1007/978-3-031-49475-8_21
Chapter

Analysis of time-to-positivity data in tuberculosis treatment studies: Identifying a new limit of quantification.

DOI
10.1101/2024.05.06.24306879
Preprint

2023

Update on drug treatments for multidrug resistant tuberculosis

Davies, G. R., & Aston, S. (2023). Update on drug treatments for multidrug resistant tuberculosis. CURRENT OPINION IN INFECTIOUS DISEASES, 36(2), 132-139. doi:10.1097/QCO.0000000000000899

DOI
10.1097/QCO.0000000000000899
Journal article

2022

Determination of the Pharmacokinetics and Pharmacodynamics of Isoniazid, Rifampicin, Pyrazinamide and Ethambutol in a Cross-Over Cynomolgus Macaque Model of <i>Mycobacterium tuberculosis</i> Infection

Sibley, L., White, A. D., Sarfas, C., Gullick, J., Gleeson, F., Lanni, F., . . . Sharpe, S. (2022). Determination of the Pharmacokinetics and Pharmacodynamics of Isoniazid, Rifampicin, Pyrazinamide and Ethambutol in a Cross-Over Cynomolgus Macaque Model of <i>Mycobacterium tuberculosis</i> Infection. PHARMACEUTICS, 14(12). doi:10.3390/pharmaceutics14122666

DOI
10.3390/pharmaceutics14122666
Journal article

Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents: a systematic review and individual patient data meta-analysis.

Gafar, F., Wasmann, R. E., McIlleron, H. M., Aarnoutse, R. E., Schaaf, H. S., Marais, B. J., . . . Global Collaborative Group for Meta-Analysis of Paediatric Individual Patient Data in Pharmacokinetics of Anti-TB Drugs. (2022). Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents: a systematic review and individual patient data meta-analysis.. The European respiratory journal, 2201596. doi:10.1183/13993003.01596-2022

DOI
10.1183/13993003.01596-2022
Journal article

High Intrapulmonary Rifampicin and Isoniazid Concentrations Are Associated With Rapid Sputum Bacillary Clearance in Patients With Pulmonary Tuberculosis

McCallum, A. D., Pertinez, H. E., Chirambo, A. P., Sheha, I., Chasweka, M., Malamba, R., . . . Mwandumba, H. C. (2022). High Intrapulmonary Rifampicin and Isoniazid Concentrations Are Associated With Rapid Sputum Bacillary Clearance in Patients With Pulmonary Tuberculosis. CLINICAL INFECTIOUS DISEASES, 75(9), 1520-1528. doi:10.1093/cid/ciac228

DOI
10.1093/cid/ciac228
Journal article

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and amikacin

Pillay, S., Steingart, K. R., Davies, G. R., Chaplin, M., De Vos, M., Schumacher, S. G., . . . Theron, G. (2022). Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and amikacin. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (5). doi:10.1002/14651858.CD014841.pub2

DOI
10.1002/14651858.CD014841.pub2
Journal article

Differences in Outcomes and Factors Associated With Mortality Among Patients With SARS-CoV-2 Infection and Cancer Compared With Those Without Cancer A Systematic Review and Meta-analysis

Khoury, E., Nevitt, S., Madsen, W. R., Turtle, L., Davies, G., & Palmieri, C. (2022). Differences in Outcomes and Factors Associated With Mortality Among Patients With SARS-CoV-2 Infection and Cancer Compared With Those Without Cancer A Systematic Review and Meta-analysis. JAMA NETWORK OPEN, 5(5). doi:10.1001/jamanetworkopen.2022.10880

DOI
10.1001/jamanetworkopen.2022.10880
Journal article

Social and health factors associated with adverse treatment outcomes among people with multidrug-resistant tuberculosis in Sierra Leone: a national, retrospective cohort study

Kamara, R. F., Saunders, M. J., Sahr, F., Losa-Garcia, J. E., Foray, L., Davies, G., & Wingfield, T. (2022). Social and health factors associated with adverse treatment outcomes among people with multidrug-resistant tuberculosis in Sierra Leone: a national, retrospective cohort study. LANCET GLOBAL HEALTH, 10(4), E543-E554. Retrieved from https://www.webofscience.com/

Journal article

2021

Optimizing Dosing and Fixed-Dose Combinations of Rifampicin, Isoniazid, and Pyrazinamide in Pediatric Patients With Tuberculosis: A Prospective Population Pharmacokinetic Study

Denti, P., Wasmann, R. E., van Rie, A., Winckler, J., Bekker, A., Rabie, H., . . . McIlleron, H. M. (2021). Optimizing Dosing and Fixed-Dose Combinations of Rifampicin, Isoniazid, and Pyrazinamide in Pediatric Patients With Tuberculosis: A Prospective Population Pharmacokinetic Study. CLINICAL INFECTIOUS DISEASES, 75(1), 141-151. doi:10.1093/cid/ciab908

DOI
10.1093/cid/ciab908
Journal article

Population pharmacokinetics and pharmacodynamics of investigational regimens' drugs in the TB-PRACTECAL clinical trial (the PRACTECAL-PKPD study): a prospective nested study protocol in a randomised controlled trial

Nyang'wa, B. -T., Kloprogge, F., Moore, D. A. J., Bustinduy, A., Motta, I., Berry, C., & Davies, G. R. (2021). Population pharmacokinetics and pharmacodynamics of investigational regimens' drugs in the TB-PRACTECAL clinical trial (the PRACTECAL-PKPD study): a prospective nested study protocol in a randomised controlled trial. BMJ OPEN, 11(9). doi:10.1136/bmjopen-2020-047185

DOI
10.1136/bmjopen-2020-047185
Journal article

2020

Longitudinal Pharmacokinetic-Pharmacodynamic Biomarkers Correlate With Treatment Outcome in Drug-Sensitive Pulmonary Tuberculosis: A Population Pharmacokinetic-Pharmacodynamic Analysis

Kloprogge, F., Mwandumba, H. C., Banda, G., Kamdolozi, M., Shani, D., Corbett, E. L., . . . Sloan, D. J. (2020). Longitudinal Pharmacokinetic-Pharmacodynamic Biomarkers Correlate With Treatment Outcome in Drug-Sensitive Pulmonary Tuberculosis: A Population Pharmacokinetic-Pharmacodynamic Analysis. OPEN FORUM INFECTIOUS DISEASES, 7(7). doi:10.1093/ofid/ofaa218

DOI
10.1093/ofid/ofaa218
Journal article

Mycobacterium tuberculosis bloodstream infection prevalence, diagnosis, and mortality risk in seriously ill adults with HIV: a systematic review and meta-analysis of individual patient data

Barr, D. A., Lewis, J. M., Feasey, N., Schutz, C., Kerkhoff, A. D., Jacob, S. T., . . . Meintjes, G. (n.d.). Mycobacterium tuberculosis bloodstream infection prevalence, diagnosis, and mortality risk in seriously ill adults with HIV: a systematic review and meta-analysis of individual patient data. The Lancet Infectious Diseases. doi:10.1016/S1473-3099(19)30695-4

DOI
10.1016/S1473-3099(19)30695-4
Journal article

Delivery of long-term-injectable agents for TB by lay carers: pragmatic randomised trial

Cohen, D. B., Mbendera, K., Maheswaran, H., Mukaka, M., Mangochi, H., Phiri, L., . . . Squire, B. (2020). Delivery of long-term-injectable agents for TB by lay carers: pragmatic randomised trial. THORAX, 75(1), 64-71. doi:10.1136/thoraxjnl-2018-212675

DOI
10.1136/thoraxjnl-2018-212675
Journal article

TB control programmes remain an important gateway to HIV diagnosis in the era of expanded access to HIV care

McCallum, A. D., Sheha, I., Chasweka, M., Banda, G., Davies, G. R., Khoo, S. H., . . . Sloan, D. J. (2020). TB control programmes remain an important gateway to HIV diagnosis in the era of expanded access to HIV care. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 24(1), 131-132. doi:10.5588/ijtld.19.0504

DOI
10.5588/ijtld.19.0504
Journal article

2019

The impact of inclusion, dose and duration of pyrazinamide (PZA) on efficacy and safety outcomes in tuberculosis: systematic review and meta-analysis protocol

Millard, J. D., Mackay, E. A., Bonnett, L. J., & Davies, G. R. (2019). The impact of inclusion, dose and duration of pyrazinamide (PZA) on efficacy and safety outcomes in tuberculosis: systematic review and meta-analysis protocol. SYSTEMATIC REVIEWS, 8(1). doi:10.1186/s13643-019-1231-1

DOI
10.1186/s13643-019-1231-1
Journal article

Protocol for the development of the STrengthening the Reporting Of Pharmacogenetic Studies (STROPS) guideline: checklist of items for reporting pharmacogenetic studies

Richardson, M., Kirkham, J. J., Dwan, K. M., Sloan, D. J., Davies, G., & Jorgensen, A. (2019). Protocol for the development of the STrengthening the Reporting Of Pharmacogenetic Studies (STROPS) guideline: checklist of items for reporting pharmacogenetic studies. BMJ OPEN, 9(7). doi:10.1136/bmjopen-2019-030212

DOI
10.1136/bmjopen-2019-030212
Journal article

Conflicting Findings on an Intermediate Dose of Rifampicin for Pulmonary Tuberculosis Reply

Velasquez, G. E., Brooks, M. B., Coit, J. M., Sanchez Garavito, E., Calderon, R. I., Jimenez, J., . . . Mitnick, C. D. (2019). Conflicting Findings on an Intermediate Dose of Rifampicin for Pulmonary Tuberculosis Reply. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 199(9), 1167-1168. doi:10.1164/rccm.201812-2281LE

DOI
10.1164/rccm.201812-2281LE
Journal article

Latent tuberculosis infection screening in HIV-infected patients: guidelines versus everyday practice in a UK HIV centre

Aston, S. J., Doherty, K., Black, B., & Davies, G. (2019). Latent tuberculosis infection screening in HIV-infected patients: guidelines versus everyday practice in a UK HIV centre. HIV MEDICINE, 20(1), E3-E4. doi:10.1111/hiv.12678

DOI
10.1111/hiv.12678
Journal article

Model-Based Relationship between the Molecular Bacterial Load Assay and Time to Positivity in Liquid Culture

Svensson, R. J., Sabiiti, W., Kibiki, G. S., Ntinginya, N. E., Bhatt, N., Davies, G., . . . Simonsson, U. S. H. (2019). Model-Based Relationship between the Molecular Bacterial Load Assay and Time to Positivity in Liquid Culture. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 63(10). doi:10.1128/AAC.00652-19

DOI
10.1128/AAC.00652-19
Journal article

2018

Moxifloxacin Replacement in Contemporary Tuberculosis Drug Regimens Is Ineffective against Persistent<i> Mycobacterium tuberculosis</i> in the Cornell Mouse Model

Liu, Y., Pertinez, H., Davies, G. R., Gillespie, S. H., Coates, A. R., & Hua, Y. (2018). Moxifloxacin Replacement in Contemporary Tuberculosis Drug Regimens Is Ineffective against Persistent<i> Mycobacterium tuberculosis</i> in the Cornell Mouse Model. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 62(7). doi:10.1128/AAC.00190-18

DOI
10.1128/AAC.00190-18
Journal article

Making up the difference: ensuring the bioequivalence of fixed-dose combinations for tuberculosis

Velasquez, G. E., Davies, G. R., & Mitnick, C. D. (2018). Making up the difference: ensuring the bioequivalence of fixed-dose combinations for tuberculosis. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 22(5), 473-474. doi:10.5588/ijtld.18.0210

DOI
10.5588/ijtld.18.0210
Journal article

Optimal doses of rifampicin in the standard drug regimen to shorten tuberculosis treatment duration and reduce relapse by eradicating persistent bacteria

Liu, Y., Pertinez, H., Ortega-Muro, F., Alameda-Martin, L., Harrison, T., Davies, G., . . . Hu, Y. (2018). Optimal doses of rifampicin in the standard drug regimen to shorten tuberculosis treatment duration and reduce relapse by eradicating persistent bacteria. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 73(3), 724-731. doi:10.1093/jac/dkx467

DOI
10.1093/jac/dkx467
Journal article

2017

Pharmacokinetic Evidence from the HIRIF Trial To Support Increased Doses of Rifampin for Tuberculosis (vol 61, e00038-17, 2017)

Peloquin, C. A., Velasquez, G. E., Lecca, L., Calderon, R. I., Coit, J., Milstein, M., . . . Daviesh, G. (2017). Pharmacokinetic Evidence from the HIRIF Trial To Support Increased Doses of Rifampin for Tuberculosis (vol 61, e00038-17, 2017). ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 61(9). doi:10.1128/AAC.01524-17

DOI
10.1128/AAC.01524-17
Journal article

Pharmacokinetic Evidence from the HIRIF Trial To Support Increased Doses of Rifampin for Tuberculosis

Peloquin, C. A., Velasquez, G. E., Lecca, L., Calderon, R. I., Coit, J., Milstein, M., . . . Davies, G. (2017). Pharmacokinetic Evidence from the HIRIF Trial To Support Increased Doses of Rifampin for Tuberculosis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 61(8). doi:10.1128/AAC.00038-17

DOI
10.1128/AAC.00038-17
Journal article

Assessment of treatment response by colony forming units, time to culture positivity and the molecular bacterial load assay compared in a mouse tuberculosis model

de Knegt, G. J., Dickinson, L., Pertinez, H., Evangelopoulos, D., McHugh, T. D., Bakker-Woudenberg, I. A. J. M., . . . de Steenwinkel, J. E. M. (2017). Assessment of treatment response by colony forming units, time to culture positivity and the molecular bacterial load assay compared in a mouse tuberculosis model. TUBERCULOSIS, 105, 113-118. doi:10.1016/j.tube.2017.05.002

DOI
10.1016/j.tube.2017.05.002
Journal article

2016

Methods for selecting regimen duration to prevent relapse in drug-susceptible and drug-resistant TB

Davies, G. R., & Wallis, R. S. (2016). Methods for selecting regimen duration to prevent relapse in drug-susceptible and drug-resistant TB. In INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE Vol. 20 (pp. S13-S17). doi:10.5588/ijtld.16.0231

DOI
10.5588/ijtld.16.0231
Conference Paper

Evaluation of high-dose rifampin in patients with new, smear-positive tuberculosis (HIRIF): study protocol for a randomized controlled trial.

Milstein, M., Lecca, L., Peloquin, C., Mitchison, D., Seung, K., Pagano, M., . . . Mitnick, C. D. (2016). Evaluation of high-dose rifampin in patients with new, smear-positive tuberculosis (HIRIF): study protocol for a randomized controlled trial.. BMC infectious diseases, 16(1), 453. doi:10.1186/s12879-016-1790-x

DOI
10.1186/s12879-016-1790-x
Journal article

Investigation of Elimination Rate, Persistent Subpopulation Removal, and Relapse Rates of Mycobacterium tuberculosis by Using Combinations of First-Line Drugs in a Modified Cornell Mouse Model

Hu, Y., Pertinez, H., Ortega-Muro, F., Alameda-Martin, L., Liu, Y., Schipani, A., . . . Coates, A. (2016). Investigation of Elimination Rate, Persistent Subpopulation Removal, and Relapse Rates of Mycobacterium tuberculosis by Using Combinations of First-Line Drugs in a Modified Cornell Mouse Model. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 60(8), 4778-4785. doi:10.1128/AAC.02548-15

DOI
10.1128/AAC.02548-15
Journal article

Optimising molecular diagnostic capacity for effective control of tuberculosis in high-burden settings

Sabiiti, W., Mtafya, B., Kuchaka, D., Azam, K., Viegas, S., Mdolo, A., . . . Biomarker, P. A. N. B. I. O. M. E. P. -A. (2016). Optimising molecular diagnostic capacity for effective control of tuberculosis in high-burden settings. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 20(8), 1004-1009. doi:10.5588/ijtld.15.0951

DOI
10.5588/ijtld.15.0951
Journal article

Serial image analysis of <i>Mycobacterium tuberculosis</i> colony growth reveals a persistent subpopulation in sputum during treatment of pulmonary TB

Barr, D. A., Kamdolozi, M., Nishihara, Y., Ndhlovu, V., Khonga, M., Davies, G. R., & Sloan, D. J. (2016). Serial image analysis of <i>Mycobacterium tuberculosis</i> colony growth reveals a persistent subpopulation in sputum during treatment of pulmonary TB. TUBERCULOSIS, 98, 110-115. doi:10.1016/j.tube.2016.03.001

DOI
10.1016/j.tube.2016.03.001
Journal article

Drug-resistant tuberculosis clinical trials: proposed core research definitions in adults

Furin, J., Alirol, E., Allen, E., Fielding, K., Merle, C., Abubakar, I., . . . du Cros, R. (2016). Drug-resistant tuberculosis clinical trials: proposed core research definitions in adults. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 20(3), 290-294. doi:10.5588/ijtld.15.0490

DOI
10.5588/ijtld.15.0490
Journal article

2015

An integrated model of care for neurological infections: the first six years of referrals to a specialist service at a university teaching hospital in Northwest England

Turtle, L., Jung, A., Beeching, N. J., Cocker, D., Davies, G. R., Nicolson, A., . . . Solomon, T. (2015). An integrated model of care for neurological infections: the first six years of referrals to a specialist service at a university teaching hospital in Northwest England. BMC INFECTIOUS DISEASES, 15. doi:10.1186/s12879-015-1109-3

DOI
10.1186/s12879-015-1109-3
Journal article

Vitamin D deficiency in Malawian adults with pulmonary tuberculosis: risk factors and treatment outcomes

Sloan, D. J., Mwandumba, H. C., Kamdolozi, M., Shani, D., Chisale, B., Dutton, J., . . . Davies, G. R. (2015). Vitamin D deficiency in Malawian adults with pulmonary tuberculosis: risk factors and treatment outcomes. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 19(8), 904-911. doi:10.5588/ijtld.15.0071

DOI
10.5588/ijtld.15.0071
Journal article

Kinetics of <i>Mycobacterium tuberculosis</i>-specific IFN-γ responses and sputum bacillary clearance in HIV-infected adults during treatment of pulmonary tuberculosis

Mzinza, D. T., Sloan, D. J., Jambo, K. C., Shani, D., Kamdolozi, M., Wilkinson, K. A., . . . Mwandumba, H. C. (2015). Kinetics of <i>Mycobacterium tuberculosis</i>-specific IFN-γ responses and sputum bacillary clearance in HIV-infected adults during treatment of pulmonary tuberculosis. TUBERCULOSIS, 95(4), 463-469. doi:10.1016/j.tube.2015.05.009

DOI
10.1016/j.tube.2015.05.009
Journal article

Pharmacodynamic Modeling of Bacillary Elimination Rates and Detection of Bacterial Lipid Bodies in Sputum to Predict and Understand Outcomes in Treatment of Pulmonary Tuberculosis

Sloan, D. J., Mwandumba, H. C., Garton, N. J., Khoo, S. H., Butterworth, A. E., Allain, T. J., . . . Davies, G. R. (2015). Pharmacodynamic Modeling of Bacillary Elimination Rates and Detection of Bacterial Lipid Bodies in Sputum to Predict and Understand Outcomes in Treatment of Pulmonary Tuberculosis. Clinical Infectious Diseases, 61(1), 1-8. doi:10.1093/cid/civ195

DOI
10.1093/cid/civ195
Journal article

Adaptive clinical trials in tuberculosis: applications, challenges and solutions

Davies, G. R., Phillips, P. P. J., & Jaki, T. (2015). Adaptive clinical trials in tuberculosis: applications, challenges and solutions. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 19(6), 626-634. doi:10.5588/ijtld.14.0988

DOI
10.5588/ijtld.14.0988
Journal article

Reply to "Adequate Design of Pharmacokinetic-Pharmacodynamic Studies Will Help Optimize Tuberculosis Treatment for the Future"

Requena-Mendez, A., Davies, G., & Moore, D. A. J. (2015). Reply to "Adequate Design of Pharmacokinetic-Pharmacodynamic Studies Will Help Optimize Tuberculosis Treatment for the Future". ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 59(4), 2475. doi:10.1128/AAC.05182-14

DOI
10.1128/AAC.05182-14
Journal article

<i>HspX</i> knock-out in <i>Mycobacterium tuberculosis</i> leads to shorter antibiotic treatment and lower relapse rate in a mouse model e A potential novel therapeutic target

Hu, Y., Liu, A., Menendez, M. C., Garcia, M. J., Oravcova, K., Gillespie, S. H., . . . Coates, A. R. M. (2015). <i>HspX</i> knock-out in <i>Mycobacterium tuberculosis</i> leads to shorter antibiotic treatment and lower relapse rate in a mouse model e A potential novel therapeutic target. TUBERCULOSIS, 95(1), 31-36. doi:10.1016/j.tube.2014.11.002

DOI
10.1016/j.tube.2014.11.002
Journal article

Use of In Vitro to In Vivo Extrapolation to Predict the Optimal Strategy for Patients Switching from Efavirenz to Maraviroc or Nevirapine

Schipani, A., Back, D., Owen, A., Davies, G., Khoo, S., & Siccardi, M. (2015). Use of In Vitro to In Vivo Extrapolation to Predict the Optimal Strategy for Patients Switching from Efavirenz to Maraviroc or Nevirapine. CLINICAL PHARMACOKINETICS, 54(1), 107-116. doi:10.1007/s40262-014-0184-8

DOI
10.1007/s40262-014-0184-8
Journal article

2014

Effects of Dosage, Comorbidities, and Food on Isoniazid Pharmacokinetics in Peruvian Tuberculosis Patients

Requena-Mendez, A., Davies, G., Waterhouse, D., Ardrey, A., Jave, O., Llanet Lopez-Romero, S., . . . Moore, D. A. J. (2014). Effects of Dosage, Comorbidities, and Food on Isoniazid Pharmacokinetics in Peruvian Tuberculosis Patients. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58(12), 7164-7170. doi:10.1128/AAC.03258-14

DOI
10.1128/AAC.03258-14
Journal article

RISK FACTORS AND THERAPEUTIC IMPLICATIONS OF VITAMIN D DEFICIENCY IN MALAWIAN ADULTS WITH PULMONARY TUBERCULOSIS

Sloan, D. J., Guwende, C., Banda, G., Shani, D., Kamdolozi, M., Chisale, B., . . . Davies, G. R. (2014). RISK FACTORS AND THERAPEUTIC IMPLICATIONS OF VITAMIN D DEFICIENCY IN MALAWIAN ADULTS WITH PULMONARY TUBERCULOSIS. In THORAX Vol. 69 (pp. A42). doi:10.1136/thoraxjnl-2014-206260.81

DOI
10.1136/thoraxjnl-2014-206260.81
Conference Paper

Effects of Dosage, Comorbidities, and Food on Isoniazid Pharmacokinetics in Peruvian Tuberculosis Patients

Requena-Méndez, A., Davies, G., Waterhouse, D., Ardrey, A., Jave, O., López-Romero, S. L., . . . Moore, D. A. J. (2014). Effects of Dosage, Comorbidities, and Food on Isoniazid Pharmacokinetics in Peruvian Tuberculosis Patients. Antimicrobial Agents and Chemotherapy, 58(12), 7164-7170. doi:10.1128/AAC.03258-14

DOI
10.1128/AAC.03258-14
Journal article

Pharmacologic Considerations in Use and Development of Antituberculosis Drugs

Davies, G. (2015). Pharmacologic Considerations in Use and Development of Antituberculosis Drugs. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 5(1). doi:10.1101/cshperspect.a021170

DOI
10.1101/cshperspect.a021170
Journal article

Pharmacokinetics of co-formulated mefloquine and artesunate in pregnant and non-pregnant women with uncomplicated <i>Plasmodium falciparum</i> infection in Burkina Faso

Valea, I., Tinto, H., Coulibaly, M. T., Toe, L. C., Lindegardh, N., Tarning, J., . . . Ward, S. A. (2014). Pharmacokinetics of co-formulated mefloquine and artesunate in pregnant and non-pregnant women with uncomplicated <i>Plasmodium falciparum</i> infection in Burkina Faso. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 69(9), 2499-2507. doi:10.1093/jac/dku154

DOI
10.1093/jac/dku154
Journal article

Clinical Tuberculosis

Davies, P. D. O., Gordon, S. B., & Davies, G. (Eds.) (n.d.). Clinical Tuberculosis. In . CRC Press. doi:10.1201/b16604

DOI
10.1201/b16604
Chapter

Pharmacokinetic Variability in TB Therapy: Associations With HIV and Effect On Outcome

Sloan, D. J., Schipani, A., Waterhouse, D., Stone, L., Mwandumba, H. C., Butterworth, A. E., . . . Davies, G. R. (2014). Pharmacokinetic Variability in TB Therapy: Associations With HIV and Effect On Outcome. Topics in Antiviral Medicine, 22(e-1), 55. Retrieved from https://www.iasusa.org/tam/april-2014

Journal article

2013

Bridging the gap in the fight against tuberculosis.

Davies, G. R. (2013). Bridging the gap in the fight against tuberculosis.. Drug discovery today. Technologies, 10(3), e359-e364. doi:10.1016/j.ddtec.2012.04.007

DOI
10.1016/j.ddtec.2012.04.007
Journal article

New Drugs and Treatment Regimens

Sloan, D., Davies, G., & Khoo, S. (2013). New Drugs and Treatment Regimens. Current Respiratory Medicine Reviews, 9(3), 200-210. doi:10.2174/1573398x113099990017

DOI
10.2174/1573398x113099990017
Journal article

Pharmacometrics: Opportunity for reducing disease burden in the developing world: The case of Africa

Pillai, G., Davies, G., Denti, P., Steimer, J. L., McIlleron, H., Zvada, S., . . . Holford, N. H. G. (2013). Pharmacometrics: Opportunity for reducing disease burden in the developing world: The case of Africa. CPT: Pharmacometrics and Systems Pharmacology, 2(9).

Journal article

Opinion: The Pharmacometrics of Infectious Disease

Davies, G. R., Hope, W., & Khoo, S. (2013). Opinion: The Pharmacometrics of Infectious Disease. CPT: Pharmacometrics &amp; Systems Pharmacology, 2(8), 1-3. doi:10.1038/psp.2013.46

DOI
10.1038/psp.2013.46
Journal article

Fluoroquinolones for treating tuberculosis (presumed drug-sensitive)

Ziganshina, L. E., Titarenko, A. F., & Davies, G. R. (2013). Fluoroquinolones for treating tuberculosis (presumed drug-sensitive). COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (6). doi:10.1002/14651858.CD004795.pub4

DOI
10.1002/14651858.CD004795.pub4
Journal article

Modelling Responses to Tuberculosis Treatment

Davies, G. R. (2013). Modelling Responses to Tuberculosis Treatment. In TUBERCULOSIS: LABORATORY DIAGNOSIS AND TREATMENT STRATEGIES (pp. 147-163). Retrieved from https://www.webofscience.com/

Chapter

Intensive phase bacillary elimination predicts clinical outcome in HIV + and HIV- Malawian adults with smear positive pulmonary TB

Sloan, D., Mwandumba, H., Guwende, C., Chipungu, G., Butterworth, A., Dutton, J., . . . Davies, G. (2013). Intensive phase bacillary elimination predicts clinical outcome in HIV + and HIV- Malawian adults with smear positive pulmonary TB. Conference on Retroviruses and Opportunistic Infections, 1, 858.

Journal article

New Drugs and Treatment Regimens for tuberculosis

Sloan, D. J., Davies, G. R., & Khoo, S. H. (2013). New Drugs and Treatment Regimens for tuberculosis. Current Respiratory Medicine Reviews, 9(3), 200-210.

Journal article

Population Pharmacokinetics of Twice Daily Zidovudine in HIV-Infected Children and an assessment of ZDV exposure following WHO dosing guidelines

Dickinson, L., Fillekes, Q., Cressey, T. R., Chokephaibulkit, K., Davies, G. R., Musiime, V., . . . Walker, S. (2013). Population Pharmacokinetics of Twice Daily Zidovudine in HIV-Infected Children and an assessment of ZDV exposure following WHO dosing guidelines. In Reviews in Antiviral Therapy and Infectious Diseases Vol. 3 (pp. 45). Retrieved from http://regist2.virology-education.com/abstractbook/2013_3.pdf

Conference Paper

Population pharmacokinetics of rifampicin in Malawian children

Schipani, A., Pertinez, H., Mlota, R., Lopez, N., Tembo, P., Ward, S., . . . Davies, G. (2013). Population pharmacokinetics of rifampicin in Malawian children. PAGE 2013, 1, I-12. Retrieved from http://www.page-meeting.org/default.asp?abstract=2782

Journal article

Simultaneous Population Pharmacokinetic Modelling of Atazanavir and Ritonavir in HIV-Infected Adults and Assessment of Different Dose Reduction Strategies

Schipani, A., Dickinson, L., Boffito, M., Austin, R., Owen, A., Back, D., . . . Davies, G. (2013). Simultaneous Population Pharmacokinetic Modelling of Atazanavir and Ritonavir in HIV-Infected Adults and Assessment of Different Dose Reduction Strategies. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 62(1), 60-66. doi:10.1097/QAI.0b013e3182737231

DOI
10.1097/QAI.0b013e3182737231
Journal article

Simultaneous population pharmacokinetic modelling of atazanavir and ritonavir in HIV-infected adults and assessment of different dose reduction strategies

Schipani, A., Dickinson, L., Boffito, M., Austin, R., Owen, A., Back, D., . . . Davies, G. (2013). Simultaneous population pharmacokinetic modelling of atazanavir and ritonavir in HIV-infected adults and assessment of different dose reduction strategies. J Acquir Immune Defic Syndr, 62(1), 60-66. doi:10.1097/QAI.0b013e3182737231

DOI
10.1097/QAI.0b013e3182737231
Journal article

The pharmacometrics of infectious diseases

Davies, G. R., Khoo, S. H., & Hope, W. (2013). The pharmacometrics of infectious diseases. CPT: Pharmacometrics and systems pharmacology, 2, e70. Retrieved from cpt:%20pharmacomet.%20syst.%20pharmacol.%202:%20e70;%20doi:10.1038/psp.2013.46

Journal article

2012

Adjunctive rifampicin to reduce early mortality from <i>Staphylococcus aureus</i> bacteraemia (ARREST): study protocol for a randomised controlled trial

Thwaites, G., Auckland, C., Barlow, G., Cunningham, R., Davies, G., Edgeworth, J., . . . Walker, A. S. (2012). Adjunctive rifampicin to reduce early mortality from <i>Staphylococcus aureus</i> bacteraemia (ARREST): study protocol for a randomised controlled trial. TRIALS, 13. doi:10.1186/1745-6215-13-241

DOI
10.1186/1745-6215-13-241
Journal article

Estimation of the effect of <i>SLCO1B1</i> polymorphisms on lopinavir plasma concentration in HIV-infected adults

Schipani, A., Egan, D., Dickinson, L., Davies, G., Boffito, M., Youle, M., . . . Owen, A. (2012). Estimation of the effect of <i>SLCO1B1</i> polymorphisms on lopinavir plasma concentration in HIV-infected adults. ANTIVIRAL THERAPY, 17(5), 861-868. doi:10.3851/IMP2095

DOI
10.3851/IMP2095
Journal article

Optimizing Outpatient Serial Sputum Colony Counting for Studies of Tuberculosis Treatment in Resource-Poor Settings

Sloan, D. J., Corbett, E. L., Butterworth, A. E., Mwandumba, H. C., Khoo, S. H., Mdolo, A., . . . Davies, G. R. (2012). Optimizing Outpatient Serial Sputum Colony Counting for Studies of Tuberculosis Treatment in Resource-Poor Settings. JOURNAL OF CLINICAL MICROBIOLOGY, 50(7), 2315-2320. doi:10.1128/JCM.00043-12

DOI
10.1128/JCM.00043-12
Journal article

In routine UK hospital practice T-SPOT.TB™ is useful in some patients with a modest pre-test probability of active tuberculosis

Turtle, L., Kemp, T., Davies, G. R., Squire, S. B., Beeching, N. J., & Beadsworth, M. B. J. (2012). In routine UK hospital practice T-SPOT.TB™ is useful in some patients with a modest pre-test probability of active tuberculosis. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 23(4), 363-367. doi:10.1016/j.ejim.2012.01.002

DOI
10.1016/j.ejim.2012.01.002
Journal article

In routine UK hospital practice T-SPOT.TB™ is useful in some patients with a modest pre-test probability of active tuberculosis.

Turtle, L., Kemp, T., Davies, G. R., Squire, S. B., Beeching, N. J., & Beadsworth, M. B. J. (2012). In routine UK hospital practice T-SPOT.TB™ is useful in some patients with a modest pre-test probability of active tuberculosis.. European journal of internal medicine, 23(4), 363-367. doi:10.1016/j.ejim.2012.01.002

DOI
10.1016/j.ejim.2012.01.002
Journal article

The chemotherapy of tuberculosis: past, present and future

Mitchison, D., & Davies, G. (2012). The chemotherapy of tuberculosis: past, present and future. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 16(6), 724-732. doi:10.5588/ijtld.12.0083

DOI
10.5588/ijtld.12.0083
Journal article

Pharmacokinetics of Rifampin in Peruvian Tuberculosis Patients with and without Comorbid Diabetes or HIV

Requena-Mendez, A., Davies, G., Ardrey, A., Jave, O., Lopez-Romero, S. L., Ward, S. A., & Moore, D. A. J. (2012). Pharmacokinetics of Rifampin in Peruvian Tuberculosis Patients with and without Comorbid Diabetes or HIV. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 56(5), 2357-2363. doi:10.1128/AAC.06059-11

DOI
10.1128/AAC.06059-11
Journal article

'I Told You So' Said the Surgeon to the Physician!

Chrdle, A., Folb, J., Davies, G., Mehra, S., Rigdway, D., & Beadsworth, M. B. J. (2012). 'I Told You So' Said the Surgeon to the Physician!. Federation of Infection Societies 2012, -. Retrieved from http://www.hisconference.org.uk/documents/Programmepagesfromv6handbook.pdf

Journal article

Bacillary Elimination Rates, Persister Phenotypes and Clinical Outcomes in a Longitudinal Study of TB Treatment in Malawi

Sloan, D. J., Mwandumba, H. C., Corbett, E. L., Butterworth, A. E., Chipungu, G., Heyderman, R. S., . . . Davies, G. R. (2012). Bacillary Elimination Rates, Persister Phenotypes and Clinical Outcomes in a Longitudinal Study of TB Treatment in Malawi. Keystone Symposium : Drug Resistance and Persistence in Tuberculosis Kampala Uganda May 2012, -.

Journal article

Clinical experience with Tspot.TB™ for diagnosis of tuberculosis in HIV negative and HIV positive patients

Turtle, L., Kemp, T., Davies, G. R., Beeching, N. J., & Beadsworth, M. B. J. (2012). Clinical experience with Tspot.TB™ for diagnosis of tuberculosis in HIV negative and HIV positive patients. Eur J Int Med, 23(4), 363-367.

Journal article

Effect of dose size and food on pharmacokinetics of isoniazid in peruvian TB patients

Requena-Mendez, A., Davies, G. R., Ardrey, A., Jave, O., Ward, S., & Moore, D. (2012). Effect of dose size and food on pharmacokinetics of isoniazid in peruvian TB patients. 5th International Workshop on the Clinical pharmacology of anti-tuberculosis drugs San Francisco 2012, -.

Journal article

Effect of limit of detection on analyses of bacteriological biomarkers in TB clinical trials

Davies, G. R., Martineau, A., & Lienhardt, C. (2012). Effect of limit of detection on analyses of bacteriological biomarkers in TB clinical trials. 5th International Workshop on the Clinical pharmacology of anti-tuberculosis drugs San Francisco 2012, -.

Journal article

Estimation of the effect of SLCO1B1 polymorphisms on lopinavir plasma concentration in HIV-infected adults

Schipani, A., Egan, D., Dickinson, L., Davies, G., Boffito, M., Youle, M., . . . Owen, A. (2012). Estimation of the effect of SLCO1B1 polymorphisms on lopinavir plasma concentration in HIV-infected adults. Antiviral Therapy, 17(5), 861-868.

Journal article

Pharmacokinetic-pharmacodynamic modelling of tuberculosis treatment response in Malawian adults with smear positive pulmonary tuberculosis

Sloan, D. J., Mwandumba, H. C., Corbett, E. L., Butterworth, A. E., Chipungu, G., Heyderman, R. S., . . . Davies, G. R. (2012). Pharmacokinetic-pharmacodynamic modelling of tuberculosis treatment response in Malawian adults with smear positive pulmonary tuberculosis. International Workshop on the Clinical pharmacology of anti-tuberculosis drugs San Francisco 2012, -.

Journal article

Predicting ritonavir-boosted saquinavir exposure in HIV-infected patients aged 2-15 years using adult data as prior information

Dickinson, L., Levi, M., Davies, G., Khoo, S., Pozniak, A., Boffito, M., & Back, D. (2012). Predicting ritonavir-boosted saquinavir exposure in HIV-infected patients aged 2-15 years using adult data as prior information. In 13th International Workshop on Clinical Pharmacology of HIV Therapy Vol. -.

Conference Paper

Rifampicin pharmacokinetics in Peruvian tuberculosis patients with and without co-morbid diabetes or HIV

Requena-Menendez, A., Davies, G. R., Ardey, A., Jave, O., López-Romero, S. L., Ward, S. A., & Moore, D. A. J. (2012). Rifampicin pharmacokinetics in Peruvian tuberculosis patients with and without co-morbid diabetes or HIV. Antimicrobial Agents & Chemotherapy, 56(5), 2357-2363.

Journal article

2011

Serial Sputum Colony Counting in Drug Development

Sloan, D., & Davies, G. (2011). Serial Sputum Colony Counting in Drug Development. In ANTITUBERCULOSIS CHEMOTHERAPY (Vol. 40, pp. 227-234). Retrieved from https://www.webofscience.com/

Chapter

Integration of population pharmacokinetics and pharmacogenetics: an aid to optimal nevirapine dose selection in HIV-infected individuals

Schipani, A., Wyen, C., Mahungu, T., Hendra, H., Egan, D., Siccardi, M., . . . Back, D. J. (2011). Integration of population pharmacokinetics and pharmacogenetics: an aid to optimal nevirapine dose selection in HIV-infected individuals. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 66(6), 1332-1339. doi:10.1093/jac/dkr087

DOI
10.1093/jac/dkr087
Journal article

Sequential Population Pharmacokinetic Modeling of Lopinavir and Ritonavir in Healthy Volunteers and Assessment of Different Dosing Strategies

Dickinson, L., Boffito, M., Back, D., Else, L., von Hentig, N., Davies, G., . . . Aarons, L. (2011). Sequential Population Pharmacokinetic Modeling of Lopinavir and Ritonavir in Healthy Volunteers and Assessment of Different Dosing Strategies. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 55(6), 2775-2782. doi:10.1128/AAC.00887-10

DOI
10.1128/AAC.00887-10
Journal article

Sequential Population Pharmacokinetic Modeling of Lopinavir and Ritonavir in Healthy Volunteers and Assessment of Different Dosing Strategies

Dickinson, L., Boffito, M., Back, D., Else, L., von Hentig, N., Davies, G., . . . Aarons, L. (2011). Sequential Population Pharmacokinetic Modeling of Lopinavir and Ritonavir in Healthy Volunteers and Assessment of Different Dosing Strategies. Antimicrobial Agents and Chemotherapy, 55(6), 2775-2782. doi:10.1128/aac.00887-10

DOI
10.1128/aac.00887-10
Journal article

High-dose vitamin D<sub>3</sub> during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial

Martineau, A. R., Timms, P. M., Bothamley, G. H., Hanifa, Y., Islam, K., Claxton, A. P., . . . Griffiths, C. J. (2011). High-dose vitamin D<sub>3</sub> during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial. LANCET, 377(9761), 242-250. doi:10.1016/S0140-6736(10)61889-2

DOI
10.1016/S0140-6736(10)61889-2
Journal article

Integrating Pharmacogenetics and Population Pharmacokinetic Analysis: Simulating the Impact of CYP2B6 516G>T for 400 mg Once-daily Nevirapine Dosing.

Schipani, A., Mahungu, T. W., Wyen, C., Esser, S., Brockmeyer, N., Khoo, S., . . . Back, D. (2011). Integrating Pharmacogenetics and Population Pharmacokinetic Analysis: Simulating the Impact of CYP2B6 516G>T for 400 mg Once-daily Nevirapine Dosing..

Journal article

Population Pharmacokinetic Modelling of Plasma and Intracellular Once Daily Ritonavir-Boosted Darunavir in HIV-Infected Patients (Abstract O_12))

Dickinson, L., Jackson, A., Garvey, L., Watson, V., Khoo, S., Winston, A., . . . Back, D. (2011). Population Pharmacokinetic Modelling of Plasma and Intracellular Once Daily Ritonavir-Boosted Darunavir in HIV-Infected Patients (Abstract O_12)). Reviews in Antiviral Therapy and Infectious Diseases, 3, 13. Retrieved from http://regist2.virology-education.com/abstractbook/2011_3.pdf

Journal article

Sequential population pharmacokinetic modelling of lopinavir and ritonavir in healthy volunteers and assessment of different dosing strategies

Dickinson, L., Boffito, M., Back, D., Else, L., von Hentig, N., Davies, G., . . . Aarons, L. (2011). Sequential population pharmacokinetic modelling of lopinavir and ritonavir in healthy volunteers and assessment of different dosing strategies. Antimicrobial Agents & Chemotherapy.

Journal article

2010

Population Pharmacokinetic Modeling of the Association between 63396C→T Pregnane X Receptor Polymorphism and Unboosted Atazanavir Clearance

Schipani, A., Siccardi, M., D'Avolio, A., Baietto, L., Simiele, M., Bonora, S., . . . Owen, A. (2010). Population Pharmacokinetic Modeling of the Association between 63396C→T Pregnane X Receptor Polymorphism and Unboosted Atazanavir Clearance. Antimicrobial Agents and Chemotherapy, 54(12), 5242-5250. doi:10.1128/aac.00781-10

DOI
10.1128/aac.00781-10
Journal article

Population Pharmacokinetic Modeling of the Association between 63396C→T Pregnane X Receptor Polymorphism and Unboosted Atazanavir Clearance

Schipani, A., Siccardi, M., D'Avolio, A., Baietto, L., Simiele, M., Bonora, S., . . . Owen, A. (2010). Population Pharmacokinetic Modeling of the Association between 63396C→T Pregnane X Receptor Polymorphism and Unboosted Atazanavir Clearance. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(12), 5242-5250. doi:10.1128/AAC.00781-10

DOI
10.1128/AAC.00781-10
Journal article

Insufficient Evidence for Chest CT Scan in TB Outbreak Investigation

Joekes, E., Davies, G., Mwandumba, H. C., & Squire, S. B. (2010). Insufficient Evidence for Chest CT Scan in TB Outbreak Investigation. CHEST, 138(1), 234-235. doi:10.1378/chest.10-0077

DOI
10.1378/chest.10-0077
Journal article

Early clinical development of anti-tuberculosis drugs: Science, statistics and sterilizing activity

Davies, G. R. (2010). Early clinical development of anti-tuberculosis drugs: Science, statistics and sterilizing activity. TUBERCULOSIS, 90(3), 171-176. doi:10.1016/j.tube.2010.03.007

DOI
10.1016/j.tube.2010.03.007
Journal article

Methodological issues in the design of clinical trials for the treatment of multidrug-resistant tuberculosis: challenges and opportunities

Lienhardt, C., & Davies, G. (2010). Methodological issues in the design of clinical trials for the treatment of multidrug-resistant tuberculosis: challenges and opportunities. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 14(5), 528-537. Retrieved from https://www.webofscience.com/

Journal article

Biomarkers for tuberculosis disease activity, cure, and relapse

Phillips, P. P. J., Davies, G. R., & Mitchison, D. A. (2010). Biomarkers for tuberculosis disease activity, cure, and relapse. LANCET INFECTIOUS DISEASES, 10(2), 69-70. doi:10.1016/S1473-3099(09)70256-7

DOI
10.1016/S1473-3099(09)70256-7
Journal article

A Population Pharmacokinetic Model Illustrates an Association between a Pregnane-X Receptor Polymorphism and Boosted Atazanavir Clearance

Schipani, A., Siccardi, M., Boffito, M., D'Avolio, A., Bonora, S., Davies, G., . . . Owen, A. (2010). A Population Pharmacokinetic Model Illustrates an Association between a Pregnane-X Receptor Polymorphism and Boosted Atazanavir Clearance. Conference on Retroviruses and Opportunistic Infections, 618. Retrieved from http://www.retroconference.org/2010/Abstracts/39338.htm

Journal article

A novel application of population pharmacokinetic analysis : simulating nevirapine dose adjustment according to CYP2B6 516G>T polymorphism

Schipani, A., Mahungu, T. W., Wyen, C., Esser, S., Brockmeyer, N. H., Khoo, S. H., . . . Back, D. J. (2010). A novel application of population pharmacokinetic analysis : simulating nevirapine dose adjustment according to CYP2B6 516G>T polymorphism. 11th Workshop on Clinical Pharmacology of HIV drugs, 20. Retrieved from http://regist2.virology-education.com/abstractbook/2010_2.pdf

Journal article

Integrating Pharmacogenetics and Population Pharmacokinetic Analysis: Simulating the Impact of CYP2B6 516G>T for 400 mg Once-daily Nevirapine Dosing

Schipani, A., Mahungu, T. W., Wyen, C., Esser, S., Brockmeyer, N., Khoo, S., . . . Back, D. (2010). Integrating Pharmacogenetics and Population Pharmacokinetic Analysis: Simulating the Impact of CYP2B6 516G>T for 400 mg Once-daily Nevirapine Dosing. Conference on Retroviruses and Opportunistic Infections, 601. Retrieved from http://www.retroconference.org/2010/Abstracts/38775.htm

Journal article

Modelling response to tuberculosis therapy

Davies, G. R. (2010). Modelling response to tuberculosis therapy. In T. D. McHugh (Ed.), Tuberculosis: progress in diagnosis & treatment (pp. 000). Wallingford, Oxford: CABI.

Chapter

Population Pharmacokinetic Modelling of Once Daily Ritonavir-Boosted Darunavir in HIV-Infected Patients

Dickinson, L., Jackson, A., Garvey, L., Watson, V., Khoo, S., Winston, A., . . . Back, D. (2010). Population Pharmacokinetic Modelling of Once Daily Ritonavir-Boosted Darunavir in HIV-Infected Patients. Journal of the International AIDS Society, 13(S4), P184.

Journal article

Population pharmacokinetic modeling of the association between 63396C->T pregnane X receptor polymorphism and unboosted atazanavir clearance

Schipani, A., Siccardi, M., D'Avolio, A., Baietto, L., Simiele, M., Bonora, S., . . . Owen, A. (2010). Population pharmacokinetic modeling of the association between 63396C->T pregnane X receptor polymorphism and unboosted atazanavir clearance. Antimicrobial Agents & Chemotherapy, 54(12), 5242-5250.

Journal article

Population pharmacokinetics of pyrazinamide in healthy volunteers and tuberculosis patients in Thailand

Davies, G. R., Cheirakul, N., Saguenwong, N., Chaiprasert, A., Chuchuttaworn, C., Eompokalap, B., . . . Khoo, S. (2010). Population pharmacokinetics of pyrazinamide in healthy volunteers and tuberculosis patients in Thailand. 3rd Int Workshop on TB-PK, P_13. Retrieved from http://regist2.virology-education.com/

Journal article

Serial sputum colony counting

Davies, G. R. (2010). Serial sputum colony counting. In P. R. Donald, & P. van Helden (Eds.), Antituberculosis Chemotherapy (pp. 000). Basel: Karger.

Chapter

2009

Population pharmacokinetics of ritonavir-boosted atazanavir in HIV-infected patients and healthy volunteers

Dickinson, L., Boffito, M., Back, D., Waters, L., Else, L., Davies, G., . . . Aarons, L. (2009). Population pharmacokinetics of ritonavir-boosted atazanavir in HIV-infected patients and healthy volunteers. Journal of Antimicrobial Chemotherapy, 63(6), 1233-1243. doi:10.1093/jac/dkp102

DOI
10.1093/jac/dkp102
Journal article

Population pharmacokinetics of ritonavir-boosted atazanavir in HIV-infected patients and healthy volunteers

Dickinson, L., Boffito, M., Back, D., Waters, L., Else, L., Davies, G., . . . Aarons, L. (2009). Population pharmacokinetics of ritonavir-boosted atazanavir in HIV-infected patients and healthy volunteers. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 63(6), 1233-1243. doi:10.1093/jac/dkp102

DOI
10.1093/jac/dkp102
Journal article

Pharmacokinetics of High-Dose Oseltamivir in Healthy Volunteers

Wattanagoon, Y., Stepniewska, K., Lindegardh, N., Pukrittayakamee, S., Silachamroon, U., Piyaphanee, W., . . . White, N. J. (2009). Pharmacokinetics of High-Dose Oseltamivir in Healthy Volunteers. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 53(3), 945-952. doi:10.1128/AAC.00588-08

DOI
10.1128/AAC.00588-08
Journal article

2008

Pharmacokinetics and pharmacodynamics in the development of anti-tuberculosis drugs

Davies, G. R., & Nuermberger, E. L. (2008). Pharmacokinetics and pharmacodynamics in the development of anti-tuberculosis drugs. TUBERCULOSIS, 88, S65-S74. doi:10.1016/S1472-9792(08)70037-4

DOI
10.1016/S1472-9792(08)70037-4
Journal article

Pharmacokinetics and pharmacodynamics in the development of anti-tuberculosis drugs.

Davies, G. R., & Nuermberger, E. L. (2008). Pharmacokinetics and pharmacodynamics in the development of anti-tuberculosis drugs.. Tuberculosis (Edinburgh, Scotland), 88 Suppl 1, S65-S74. doi:10.1016/s1472-9792(08)70037-4

DOI
10.1016/s1472-9792(08)70037-4
Journal article

Doubts about DOTS - It's too soon to say that direct observation of short courses of tuberculosis treatment is failing

Davies, G. R., & Squire, S. B. (2008). Doubts about DOTS - It's too soon to say that direct observation of short courses of tuberculosis treatment is failing. BMJ-BRITISH MEDICAL JOURNAL, 336(7642), 457-458. doi:10.1136/bmj.39464.485208.80

DOI
10.1136/bmj.39464.485208.80
Journal article

A Factorial Study of the Effect of HIV, TB, and Pharmacogenetics on the Pharmacokinetics and Pharmacodynamics of Anti-TB Drugs

Davies, G., Cheirakul, N., Saguenwong, N., Chaiprasert, A., Chuchuttaworn, C., Eompokalap, B., . . . Khoo, S. (2008). A Factorial Study of the Effect of HIV, TB, and Pharmacogenetics on the Pharmacokinetics and Pharmacodynamics of Anti-TB Drugs. Conference on Retroviruses and Opportunistic Infections, O-1005. Retrieved from http://www.retroconference.org/2008/Abstracts/31198.htm

Journal article

A Phase II study of the sterilising activities of ofloxacin, gatifloxacin and moxifloxacin in pulmonary tuberculosis

Rustomjee, R., Lienhardt, C., Kanyok, T., Davies, G. R., Levin, J., Mthiyane, T., . . . Mitchison, D. A. (2008). A Phase II study of the sterilising activities of ofloxacin, gatifloxacin and moxifloxacin in pulmonary tuberculosis. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 12(2), 128-138. Retrieved from https://www.webofscience.com/

Journal article

2007

Rifabutin for treating pulmonary tuberculosis

Davies, G., Cerri, S., & Richeldi, L. (2007). Rifabutin for treating pulmonary tuberculosis. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (4). doi:10.1002/14651858.CD005159.pub2

DOI
10.1002/14651858.CD005159.pub2
Journal article

A rapid and sensitive HPLC-MS method for the detection of plasma and cellular rifampicin

Hartkoorn, R. C., Khoo, S., Back, D. J., Tjia, J. F., Waitt, C. J., Chaponda, M., . . . Ward, S. A. (2007). A rapid and sensitive HPLC-MS method for the detection of plasma and cellular rifampicin. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 857(1), 76-82. doi:10.1016/j.jchromb.2007.07.005

DOI
10.1016/j.jchromb.2007.07.005
Journal article

Biomarkers and surrogate end points in clinical trials of tuberculosis treatment

Davies, G. R., Phillips, P. P. J., & Nunn, A. J. (2007). Biomarkers and surrogate end points in clinical trials of tuberculosis treatment. JOURNAL OF INFECTIOUS DISEASES, 196(4), 648-649. doi:10.1086/519744

DOI
10.1086/519744
Journal article

Isoniazid activity is terminated by bacterial persistence

Mitchison, D. A., Jindani, A., Davies, G. R., & Sirgel, F. (2007). Isoniazid activity is terminated by bacterial persistence. JOURNAL OF INFECTIOUS DISEASES, 195(12), 1871-1872. doi:10.1086/518046

DOI
10.1086/518046
Journal article

Importance of collection tube during clinical studies of oseltamivir

Lindegardh, N., Davies, G. R., Hien, T. T., Farrar, J., Singhasivanon, P., Day, N. P. J., & White, N. J. (2007). Importance of collection tube during clinical studies of oseltamivir. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 51(5), 1835-1836. doi:10.1128/AAC.01534-06

DOI
10.1128/AAC.01534-06
Journal article

Evaluation of new antituberculosis drugs in mouse models

Davies, G. R., Pym, A. S., & Mitchison, D. A. (2007). Evaluation of new antituberculosis drugs in mouse models. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 51(1), 403. doi:10.1128/AAC.01246-06

DOI
10.1128/AAC.01246-06
Journal article

2006

Mixture analysis of tuberculin survey data from northern Malawi and critique of the method

Davies, G. R., Fine, P. E., & Vynnycky, E. (2006). Mixture analysis of tuberculin survey data from northern Malawi and critique of the method. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 10(9), 1023-1029. Retrieved from https://www.webofscience.com/

Journal article

Optimal sampling strategies for early pharmacodynamic measures in tuberculosis

Davies, G. R., Khoo, S. H., & Aarons, L. J. (2006). Optimal sampling strategies for early pharmacodynamic measures in tuberculosis. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 58(3), 594-600. doi:10.1093/jac/dkl272

DOI
10.1093/jac/dkl272
Journal article

Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases

Lindegardh, N., Davies, G. R., Hien, T. T., Farrar, J., Singhasivanon, P., Day, N. P. J., & White, N. J. (2006). Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 50(9), 3197-3199. doi:10.1128/AAC.00500-06

DOI
10.1128/AAC.00500-06
Journal article

Use of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatment

Davies, G. R., Brindle, R., Khoo, S. H., & Aarons, L. J. (2006). Use of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatment. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 50(9), 3154-3156. doi:10.1128/AAC.00774-05

DOI
10.1128/AAC.00774-05
Journal article

2003

Sales of over-the-counter remedies as an early warning system for winter bed crises

Davies, G. R., & Finch, R. G. (2003). Sales of over-the-counter remedies as an early warning system for winter bed crises. CLINICAL MICROBIOLOGY AND INFECTION, 9(8), 858-863. doi:10.1046/j.1469-0691.2003.00693.x

DOI
10.1046/j.1469-0691.2003.00693.x
Journal article

2002

Loss of cytomegalovirus-specific immunological memory in a patient with thymoma

Huissoon, A. P., Davies, G., Cox, R. A., Sloper, C. M. L., Thomson, B. J., & Robins, R. A. (2002). Loss of cytomegalovirus-specific immunological memory in a patient with thymoma. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 129(2), 297-301. doi:10.1046/j.1365-2249.2002.01923.x

DOI
10.1046/j.1365-2249.2002.01923.x
Journal article

Successful conservative management of splenic rupture in vivax malaria

Davies, G. R., & Venkatesan, P. (2002). Successful conservative management of splenic rupture in vivax malaria. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 96(2), 149-150. doi:10.1016/S0035-9203(02)90285-3

DOI
10.1016/S0035-9203(02)90285-3
Journal article

2001

Fever of unknown origin

Davies, G. R., & Finch, R. G. (2001). Fever of unknown origin. CLINICAL MEDICINE, 1(3), 177-179. doi:10.7861/clinmedicine.1-3-177

DOI
10.7861/clinmedicine.1-3-177
Journal article

1999

Who fails to complete tuberculosis treatment? Temporal trends and risk factors for treatment interruption in a community-based directly observed therapy programme in a rural district of South Africa

Connolly, C., Davies, G. R., & Wilkinson, D. (1999). Who fails to complete tuberculosis treatment? Temporal trends and risk factors for treatment interruption in a community-based directly observed therapy programme in a rural district of South Africa. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 3(12), 1081-1087. Retrieved from https://www.webofscience.com/

Journal article

Twice-weekly, directly observed treatment for HIV-infected and uninfected tuberculosis patients: cohort study in rural South Africa

Davies, G. R., Connolly, C., Sturm, A. W., McAdam, K. P. W. J., & Wilkinson, D. (1999). Twice-weekly, directly observed treatment for HIV-infected and uninfected tuberculosis patients: cohort study in rural South Africa. AIDS, 13(7), 811-817. doi:10.1097/00002030-199905070-00010

DOI
10.1097/00002030-199905070-00010
Journal article

Emergence of multidrug-resistant tuberculosis in a community-based directly observed treatment programme in rural South Africa

Davies, G. R., Pillay, M., Sturm, A. W., & Wilkinson, D. (1999). Emergence of multidrug-resistant tuberculosis in a community-based directly observed treatment programme in rural South Africa. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 3(9), 799-804. Retrieved from https://www.webofscience.com/

Journal article

1998

Impact of the human immunodeficiency virus epidemic on mortality among adults with tuberculosis in rural South Africa, 1991-1995

Connolly, C., Davies, G. R., & Wilkinson, D. (1998). Impact of the human immunodeficiency virus epidemic on mortality among adults with tuberculosis in rural South Africa, 1991-1995. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2(11), 919-925. Retrieved from https://www.webofscience.com/

Journal article

Pediatric tuberculosis in rural South Africa - Value of directly observed therapy

Wilkinson, D., & Davies, G. R. (1998). Pediatric tuberculosis in rural South Africa - Value of directly observed therapy. JOURNAL OF TROPICAL PEDIATRICS, 44(5), 266-269. doi:10.1093/tropej/44.5.266

DOI
10.1093/tropej/44.5.266
Journal article

1997

The increasing burden of tuberculosis in rural South Africa - Impact of the HIV epidemic

Wilkinson, D., & Davies, G. R. (1997). The increasing burden of tuberculosis in rural South Africa - Impact of the HIV epidemic. SOUTH AFRICAN MEDICAL JOURNAL, 87(4), 447-450. Retrieved from https://www.webofscience.com/

Journal article

Coping with Africa's increasing tuberculosis burden: Are community supervisors an essential component of the DOT strategy?

Wilkinson, D., & Davies, G. R. (1997). Coping with Africa's increasing tuberculosis burden: Are community supervisors an essential component of the DOT strategy?. TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2(7), 700-704. doi:10.1046/j.1365-3156.1997.d01-358.x

DOI
10.1046/j.1365-3156.1997.d01-358.x
Journal article

Efficacy of twice weekly treatment for tuberculosis given under direct observation in Africa

Wilkinson, D., Anderson, E., Davies, G. R., Sturm, A. W., & McAdam, K. P. W. J. (1997). Efficacy of twice weekly treatment for tuberculosis given under direct observation in Africa. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 91(1), 87-89. doi:10.1016/S0035-9203(97)90407-7

DOI
10.1016/S0035-9203(97)90407-7
Journal article

Molecular epidemiology and transmission dynamics of Mycobacterium tuberculosis in rural Africa

Wilkinson, D., Pillay, M., Crump, J., Lombard, C., Davies, G. R., & Sturm, A. W. (1997). Molecular epidemiology and transmission dynamics of Mycobacterium tuberculosis in rural Africa. TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2(8), 747-753. doi:10.1046/j.1365-3156.1997.d01-386.x

DOI
10.1046/j.1365-3156.1997.d01-386.x
Journal article

1996

Directly observed therapy for tuberculosis in rural South Africa, 1991 through 1994

Wilkinson, D., Davies, G. R., & Connolly, C. (1996). Directly observed therapy for tuberculosis in rural South Africa, 1991 through 1994. AMERICAN JOURNAL OF PUBLIC HEALTH, 86(8), 1094-1097. doi:10.2105/AJPH.86.8_Pt_1.1094

DOI
10.2105/AJPH.86.8_Pt_1.1094
Journal article

HIV and tuberculosis

Davies, G. R., Wilkinson, D., & Colvin, M. (1996). HIV and tuberculosis. SOUTH AFRICAN MEDICAL JOURNAL, 86(1), 91. Retrieved from https://www.webofscience.com/

Journal article

Resistance to antituberculosis drugs in rural South Africa: Rates, patterns, risks, and transmission dynamics

Wilkinson, D., Pillay, M., Davies, G. R., & Sturm, A. W. (1996). Resistance to antituberculosis drugs in rural South Africa: Rates, patterns, risks, and transmission dynamics. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 90(6), 692-695. doi:10.1016/S0035-9203(96)90440-X

DOI
10.1016/S0035-9203(96)90440-X
Journal article