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Professor Enitan Carrol
MBChB, MRCP, FRCPCH, MD, DTMH, PG Cert. Dip.Med.Sci, FHEA

Research

Serious Bacterial Infections in Children

Host response to bacterial infection
Sepsis
Early recognition of serious infection
Diagnostic markers of bacterial /viral Infection including sepsis
Invasive pneumococcal and meningococcal infection
Antimicrobial stewardship

Funding- NIHR HTA Programme (BATCH Trial: CI, PRONTO Trial: Co:I), H2020 ( EUCLIDS: Co-I, PERFORM: Co-I,. DIAMONDS Co-I)

https://www.cardiff.ac.uk/centre-for-trials-research/research/studies-and-trials/view/batch
https://www.cardiff.ac.uk/centre-for-trials-research/research/studies-and-trials/view/pronto
https://www.perform2020.org/

Recent news:
https://news.liverpool.ac.uk/2020/01/20/rapid-test-could-diagnose-serious-conditions-within-two-hours/

https://news.liverpool.ac.uk/2017/09/27/watch/

Paediatric Early Warning Scores

Use of electronic surveillance systems
Early identification of deterioration including sepsis

Funding -NIHR i4i Programme (DETECT Study: co-CI)

Research grants

NIHR ARC 2 national social care implementation projects

DEPARTMENT OF HEALTH & SOCIAL CARE (UK), LCCG - LIVERPOOL CLINICAL COMMISSIONING GROUP (UK)

October 2019 - March 2026

ADAPT

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

September 2019 - March 2022

Attenuated Total Reflection Fourier transform infrared (ATR-FTIR) spectroscopy point-of-care testing for the detection of sepsis pathogens

CENTRE OF EXCELLENCE IN INFECTIOUS DISEASES RESEARCH (UK)

September 2019 - June 2021

A cluster randomised trial to evaluate the effectiveness of household alcohol-based handrub for the prevention of sepsis, diarrhoea and pneumonia in Ugandan infants (Babygel)

EUROPEAN AND DEVELOPING COUNTRIES CLINICAL TRIALS PARTNERSHIP (EDCTP) - (NETHERLANDS), EUROPEAN AND DEVELOPING COUNTRIES CLINICAL TRIALS PARTNERSHIP - (NETHERLANDS)

February 2019 - January 2025

Clinical Research Network North West Coast (CRN NWC):

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

October 2018 - December 2021

Research Capability Funding

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

February 2018 - July 2019

Research Capability Funding

LCCG - LIVERPOOL CLINICAL COMMISSIONING GROUP (UK)

July 2018 - December 2018

Dynamic Electronic Tracking and Escalation to reduce Critical Care Transfers (The DETECT study)

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK), DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

October 2018 - August 2022

Biomarker-guided duration of antibiotic treatment in hospitalised children with confirmed or suspected sepsis (BATCH)

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

September 2017 - June 2024

Before Arrival at Hospital: Children’s journeys to hospital in serious infectious illness.(The BeArH project)

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

October 2017 - September 2019

Personalising sepsis therapy in children through improved mechanistic understanding of phagocytic killing

ALDER HEY CHILDREN'S CHARITY (UK), ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

September 2016 - March 2020

PERFORM: Personalised Risk assessment in febrile illness to Optimise Real-life Management across the European Union.

EUROPEAN COMMISSION

January 2016 - June 2021

Increasing Industry Engagement and Open Innovation in Health and Life Sciences - Proximity to Discovery Award

MEDICAL RESEARCH COUNCIL

March 2016 - August 2017

Development of a urine-based point-of-care test for adherence to antiretroviral drugs

NATIONAL INSTITUTES OF HEALTH (USA)

December 2015 - November 2021

Avacta Life Sciences and Infection and Global Health KTP.

AVACTA GROUP PLC (UK), INNOVATE UK (UK)

November 2015 - May 2018

EUCLIDS - EU childhood life threatening infectious diseases genetics study

EUROPEAN COMMISSION

September 2011 - May 2017

Impact Acceleration Account - University of Liverpool 2012

ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL

October 2012 - March 2017

Assessment of point-of-care biomarker devices to support and inform clinical decisions in febrile children presenting to the emergency department

ALDER HEY IMAGINE APPEAL (UK)

March 2012 - December 2014

FSF Clinical Research Fellow in Paediatric Infectious Diseases

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

October 2010 - September 2012

Paediatric early warning system Utilisation and Mortality Avoidance (“PUMA”): a prospective, mixed methods, before and after study.

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

November 2014 - October 2019

Bridging and accelerating the translation of novel scientific findings for health and wealth gain

MEDICAL RESEARCH COUNCIL

March 2014 - August 2015

A cluster randomised trial of maternal alcohol hand gel to prevent newborn infection (BabyGel)

MEDICAL RESEARCH COUNCIL

April 2015 - July 2016

Understanding the epidemiology of life threatening invasive Group A Streptococcal infections in Merseyside.

LIVERPOOL HEALTH PARTNERS (UK)

March 2013 - April 2013

DISTINCTIVE - Diagnostic comparison of procalcitonin and the aPTT biphasic waveform in children with bacterial sepsis on the intensive care unit

ALDER HEY IMAGINE APPEAL (UK), DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

September 2010 - August 2014

IMPACT/SBRI Study (Alder Hey)

INNOVATE UK (UK)

July 2014 - August 2014

Predicting Influenza severity by proteomics (PrInSeP).

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

January 2014 - June 2016

Characterisation of Clostridium difficile strains in neonates and children and its epidemiological relevance in relation to the circulating adult strains and the onset of disease

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

August 2013 - July 2014

Development of a rapid salivary test to detect serious bacterial infection in children presenting to the accident and emergency department. SPICED.

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

September 2010 - May 2012

The validation of a novel point of care device to detect serious bacterial infection in children attending the emergency department

ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

May 2011 - December 2014

The role of the Microcirculation in the Pathophysiology of Meningococcal Disease.

JOHANNE HOLLY MENINGITIS FUND, MENINGITIS RESEARCH FOUNDATION (UK)

January 2009 - September 2010

WELLCOME VIP2007/08

WELLCOME TRUST (UK)

October 2007 - September 2008

Investigation of the cytokine profile in invasive pneumococcal disease and host determinants of disease susceptibility and severity in Malawian children.

ROYAL LIVERPOOL CHILDREN'S NHS TRUST (CHARITABLE) (UK), WELLCOME TRUST (UK)

May 2003 - July 2009

RESOLuTION study: Rapid Electrochemical bioSensor technOLogy for the integrated diagnosis of serious childhood infecTION

MICROLAB DEVICES LTD (UK)

November 2012 - April 2014

    Research collaborations

    Prof Martin Antonio

    MRC Gambia ?LSHTM

    Co investigator aetiology of bacterial meningitis

    Dr Matt Johnson

    Avacta Ltd

    Research and Development

    Federico Martinón-Torres MD, PhD, Assoc Prof

    Hospital Clínico Universitario de Santiago de Compostela