Research
Gastrointestinal tumour development
My current research interests involves two main themes, firstly investigating the importance of apoptosis, inflammation and NFκB signalling in the pathogenesis of gastrointestinal diseases and secondly elucidating the importance of the gastrin family of peptides in the pathogenesis of gastric and colorectal neoplasms.
My research employs a wide range of techniques including cell lines, transgenic mouse models and biopsies from human patients. Primary organoids from mouse and human gastric epithelia are widely employed.
Research grants
TransQST: Translational quantitative systems toxicology to improve the understanding of the safety of medicines
EUROPEAN COMMISSION
January 2017 - August 2022
Bench fees for Mr Esam Meftah Ali Shahout (201117020)
LIBYAN EMBASSY IN LONDON🚩
December 2019 - November 2023
Bench Fees for Sumeia Ghannay (201382673)
LIBYAN EMBASSY IN LONDON🚩
January 2021 - January 2025
Investigation of the importance of gastrin/cholecystokinin-2 receptor expression and of its inhibition by netazepide in gastric and duodenal neuroendocrine tumours.
TRIO MEDICINES LIMITED (UK)
August 2018 - January 2021
Study to determine the effect of ferric maltol on gut microbiota in inflammatory bowel disease patients with iron deficiency
SHIELD THERAPEUTICS PLC (UK)
January 2018 - January 2019
MECNUT: Impact of dietary exposure to emulsifiers on the intestinal mucosa - implications for inflammatory bowel disease and metabolic syndrome
MEDICAL RESEARCH COUNCIL
November 2017 - September 2021
Investigating the impact of Streptococcus gallolyticus infection on epithelial cell turnover in an enteroid model
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
January 2017 - January 2018
Investigation of a novel gastrin receptor antagonist
TRIO MEDICINES LIMITED (UK)
October 2015 - September 2019
Targeting intestinal epithelial cell shedding using NF-kB inhibitors to ameliorate sepsis
FIONA ELIZABETH AGNEW TRUST (UK)
June 2016 - May 2017
Gastrin and C-Kit in Gastric Cancer.
ROYAL SOCIETY (CHARITABLE)
September 2000 - August 2001
Genetics of non-steroidal anti-inflammatory drugs (NSAIDs)-induced peptic ulceration: a genome wide association study.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
July 2010 - June 2011
Identification of patients at risk of gastric cancer
NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)
February 2014 - January 2015
Role of MMP-7 in the pathogenesis of gastric cancer.
NORTH WEST CANCER RESEARCH FUND
November 2003 - November 2006
The role of NF-kB and cell shedding in inflammatory Bowel Disease
WELLCOME TRUST (UK)
August 2011 - May 2014
Validation and exploitation of biomarkers for identification of patients at risk of gastric cancer
NORTH WEST CANCER RESEARCH FUND
November 2012 - October 2014
Development of primary cultures of human colonic epithelium.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
September 2005 - August 2007
Mechanisms of promotion of colorectal carcinogenesis by the non-amidated precursors of gastrin in vitro and in vivo.
NORTH WEST CANCER RESEARCH FUND
January 2001 - August 2004
Identification of patients at risk of gastric cancer due to helicobacter pylori infection
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
September 2007 - March 2012
Epithelial cell shedding induced gut barrier dysfunction
LIBYAN EMBASSY IN LONDON🚩
October 2014 - September 2015
Role of NF-kappaB signalling in acute experimental pancreatitis
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
March 2014 - February 2015
Investigation of the mechanisms by which progastrin promotes colonic carcinogenesis.
NORTH WEST CANCER RESEARCH FUND
June 2006 - December 2010
Investigation of the intestinal microbiome of mice which have aberrant NF-kappaB signalling
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
August 2014 - July 2015
Bridging and accelerating the translation of novel scientific findings for health and wealth gain
MEDICAL RESEARCH COUNCIL
March 2014 - August 2015
Investigation of the importance of individual members of the Nuclear Factor-kappaB (NF-kB) family during Helicobacter pylori-induced gastric carcinogenesis
WELLCOME TRUST (UK)
April 2008 - March 2011
Towards disease diagnosis through spectrochemical imaging of tissue architecture.
ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL
June 2013 - September 2016
Assessment of the abundance of potential biomarkers of colorectal neoplasia in human patients
CANCER RESEARCH UK (UK)
July 2010 - September 2011
Importance of alternative pathway NF-κB signalling in Helicobacter-induced gastric carcinogenesis
NORTH WEST CANCER RESEARCH FUND
January 2013 - September 2016
How does the gastrin/CCK-2 receptor antagonist netazepide (YF476) alter gastric mucosal gene expression in patients with type I gastric neuroendocrine tumours?
UKI NETS (UK)
January 2014 - December 2014
The role of NF-kB and cell shedding in Inflammatory Bowel Disease.
WELLCOME TRUST (UK)
September 2009 - September 2012
Pathogenesis of type 1 gastric carcinoid tumours.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
September 2006 - August 2008
Investigation of the importance of the gastrin family of peptides and gastrin/CCKb receptor in inflammatory bowel disease.
NAT ASSOC FOR COLITIS & CROHNS DISEASE (UK)
September 2003 - September 2007
Systems medicine of chronic inflammatory bowel disease (SysmedIBD)
EUROPEAN COMMISSION
December 2012 - November 2017
Gastrin and its receptor inflammatory bowel disease.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
September 2003 - February 2007
Investigation of the genetic regulation of apoptosis in the stomach, with particular reference to the development of gastric atrophy.
WELLCOME TRUST (UK)
September 2002 - December 2007
Characterisation and assessment of the functional impact on gastric preneoplasia of the non-Helicobacter gastric dysbiosis of Nfkb1-/- and Nfkb2-/- mice
GUTS (UK CHARITY)
February 2014 - January 2015
How does the microbiome of the hypochlorhydric stomach promote gastric tumourigenesis?
WORLDWIDE CANCER RESEARCH (UK)
November 2012 - October 2015