Publications
2024
Contact X-ray Brachytherapy as a sole treatment in selected patients with early rectal cancer – Multi-centre study
Wah Than, N., Mark Pritchard, D., Hughes, D. M., Shing Yu, K., Minnaar, H. S., Dhadda, A., . . . Sun Myint, A. (2024). Contact X-ray Brachytherapy as a sole treatment in selected patients with early rectal cancer – Multi-centre study. Clinical and Translational Radiation Oncology, 100851. doi:10.1016/j.ctro.2024.100851
Microbiome-driven IBS metabotypes influence response to the low FODMAP diet: insights from the faecal volatome.
Conley, T. E., Slater, R., Moss, S., Bulmer, D. C., Negro, J. D. L. R., Ijaz, U. Z., . . . Probert, C. (2024). Microbiome-driven IBS metabotypes influence response to the low FODMAP diet: insights from the faecal volatome.. EBioMedicine, 107, 105282. doi:10.1016/j.ebiom.2024.105282
Sequence of Contact X-ray Brachytherapy (CXB) and External Beam Radiation (EBRT) in organ-preserving treatment for small rectal cancer
Than, N. W., Pritchard, D. M., Hughes, D. M., Duckworth, C. A., Wong, H., Ul Haq, M., . . . Myint, A. S. (2024). Sequence of Contact X-ray Brachytherapy (CXB) and External Beam Radiation (EBRT) in organ-preserving treatment for small rectal cancer. Radiotherapy and Oncology, 110465. doi:10.1016/j.radonc.2024.110465
Contact x-ray brachytherapy for the treatment of rectal cancer: A systematic review and meta-analysis.
Powell, S. G., Wyatt, J., Haq, M., Than, N., Javed, A., Ahmed, S., . . . Sun Myint, A. (2024). Contact x-ray brachytherapy for the treatment of rectal cancer: A systematic review and meta-analysis.. Journal of Clinical Oncology, 42(16_suppl), e15628. doi:10.1200/jco.2024.42.16_suppl.e15628
O63 The clinical relevance of the emerging short chain fatty acid metabotype in irritable bowel syndrome
Conley, T., Slater, R., Spiller, R., Pritchard, D. M., & Probert, C. (2024). O63 The clinical relevance of the emerging short chain fatty acid metabotype in irritable bowel syndrome. In Oral Presentations (pp. A39-A40). BMJ Publishing Group Ltd and British Society of Gastroenterology. doi:10.1136/gutjnl-2024-bsg.63
O64 Microbiome-driven metabotypes influence response to the low FODMAP diet in IBS and implicate short chain fatty acids
Conley, T., Slater, R., Bulmer, D., Moss, S., Negro, J. D. L. R., Ijaz, U., . . . Probert, C. (2024). O64 Microbiome-driven metabotypes influence response to the low FODMAP diet in IBS and implicate short chain fatty acids. In Oral Presentations (pp. A40-A41). BMJ Publishing Group Ltd and British Society of Gastroenterology. doi:10.1136/gutjnl-2024-bsg.64
O84 Exploring the potential short chain fatty acid-serotonin axis in irritable bowel: insights from an integrated faecal and urinary metabolomic analysis
Conley, T., Slater, R., Burke, A., Gotts, N., Wilson, B., Pritchard, D. M., . . . Probert, C. (2024). O84 Exploring the potential short chain fatty acid-serotonin axis in irritable bowel: insights from an integrated faecal and urinary metabolomic analysis. In Late Breaking Abstracts (pp. A295.2-A296). BMJ Publishing Group Ltd and British Society of Gastroenterology. doi:10.1136/gutjnl-2024-bsg.483
Radiation dose esclation with contact X-ray brachytherapy (Papillon) and quality of life in patients with rectal cancer: Results from the phase 3 randomised trial OPERA.
Sun Myint, A., Than, N., Pacé-Loscos, T., Schiappa, R., Ai-Haq, M., Sripadam, R., . . . Gerard, J. P. (2024). Radiation dose esclation with contact X-ray brachytherapy (Papillon) and quality of life in patients with rectal cancer: Results from the phase 3 randomised trial OPERA.. Journal of Clinical Oncology, 42(16_suppl), e23180. doi:10.1200/jco.2024.42.16_suppl.e23180
Multiple and diverse consequences of inhibiting gastric acid secretion: remembering the bicentenary of William Prout's discovery
Pritchard, D. M., & Logan, R. (2023). Multiple and diverse consequences of inhibiting gastric acid secretion: remembering the bicentenary of William Prout's discovery. GUT. doi:10.1136/gutjnl-2023-330133
1340: Timing of Contact X-ray Brachytherapy in organ-preserving treatment of small rectal cancer
Than, N. W., Pritchard, D. M., Duckworth, C., Hughes, D., & Myint, S. (2024). 1340: Timing of Contact X-ray Brachytherapy in organ-preserving treatment of small rectal cancer. Radiotherapy and Oncology, 194, S179-S182. doi:10.1016/s0167-8140(24)01756-0
2565: Clinical prediction models for contact brachytherapy in managing rectal cancers: A scoping review
Haq, M. U., Hughes, D. M., Myint, A. S., Duckworth, C., Pritchard, D. M., & Bonnett, L. J. (2024). 2565: Clinical prediction models for contact brachytherapy in managing rectal cancers: A scoping review. Radiotherapy and Oncology, 194, S189-S193. doi:10.1016/s0167-8140(24)02746-4
Timing of Contact X-ray Brachytherapy in organ-preserving treatment of rectal cancer
Than, N., Pritchard, D. M., Duckworth, C. A., Hughes, D. M., & Myint, A. S. (2024). Timing of Contact X-ray Brachytherapy in organ-preserving treatment of rectal cancer. In ESTRO 2024 Vol. 194 Supplement 1 (pp. 186-189). Glasgow, UK: Journal of the European Society for Raidotherapy and Oncology. Retrieved from https://user-swndwmf.cld.bz/ESTRO-2024-Abstract-Book/186/
Contact X-ray brachytherapy (CXB) as a salvage treatment for rectal cancer patients who developed local tumor re-growth after watch-and-wait approach.
Than, N. W., Pritchard, D. M., Duckworth, C. A., Hughes, D. M., Wong, H., Sripadam, R., & Myint, A. S. (2024). Contact X-ray brachytherapy (CXB) as a salvage treatment for rectal cancer patients who developed local tumor re-growth after watch-and-wait approach.. Journal of contemporary brachytherapy, 16(2), 95-102. doi:10.5114/jcb.2024.139049
Neuroendocrine neoplasms: Consensus on a patient care pathway.
Hooper, J., Jervis, N., Morgan, L., Beckett, V., Hand, P., Higgs, K., . . . Ellis, C. B. (2024). Neuroendocrine neoplasms: Consensus on a patient care pathway.. Journal of neuroendocrinology, 36(4), e13380. doi:10.1111/jne.13380
PREF-NET: A patient preference and experience study of lanreotide autogel (LAN) administered in the home versus hospital setting among patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in the UK
Khan, M., Davies, L., Back, M., Shah, T., Pritchard, D., Cook, K., . . . Higgs, K. (2023). PREF-NET: A patient preference and experience study of lanreotide autogel (LAN) administered in the home versus hospital setting among patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in the UK. In JOURNAL OF NEUROENDOCRINOLOGY Vol. 35 (pp. 225). Retrieved from https://www.webofscience.com/
PREF-NET: a patient preference and experience study of lanreotide autogel administered in the home versus hospital setting among patients with gastroenteropancreatic neuroendocrine tumours in the UK.
Khan, M. S., Cook, K., Weickert, M. O., Davies, L., Pritchard, D. M., Day, M., . . . Higgs, K. (2024). PREF-NET: a patient preference and experience study of lanreotide autogel administered in the home versus hospital setting among patients with gastroenteropancreatic neuroendocrine tumours in the UK.. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 32(3), 199. doi:10.1007/s00520-024-08377-7
2023
Homeostasis, injury, and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt.
Gall, L., Duckworth, C., Jardi, F., Lammens, L., Parker, A., Bianco, A., . . . Pin, C. (2023). Homeostasis, injury, and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt.. eLife, 12, e85478. doi:10.7554/elife.85478
Letter to the editor: <i>Helicobacter pylori</i> eradication - the proof is not in the symptoms
Bornschein, J., Pritchard, D. M., & Malfertheiner, P. (2022). Letter to the editor: <i>Helicobacter pylori</i> eradication - the proof is not in the symptoms. GUT. doi:10.1136/gutjnl-2022-329057
A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug-induced toxicity.
Gall, L., Jardi, F., Lammens, L., Piñero, J., Souza, T. M., Rodrigues, D., . . . Pin, C. (2023). A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug-induced toxicity.. CPT: pharmacometrics & systems pharmacology. doi:10.1002/psp4.13029
European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for gastroduodenal neuroendocrine tumours (NETs) G1-G3
Panzuto, F., Ramage, J., Pritchard, D. M., van Velthuysen, M. -L. F., Schrader, J., Begum, N., . . . O'Toole, D. (2023). European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for gastroduodenal neuroendocrine tumours (NETs) G1-G3. JOURNAL OF NEUROENDOCRINOLOGY. doi:10.1111/jne.13306
Galectin-3 promotes secretion of proteases that decrease epithelium integrity in human colon cancer cells
Li, S., Pritchard, D. M., & Yu, L. -G. (2023). Galectin-3 promotes secretion of proteases that decrease epithelium integrity in human colon cancer cells. CELL DEATH & DISEASE, 14(4). doi:10.1038/s41419-023-05789-x
The Role of Contact X-Ray Brachytherapy in Early Rectal Cancer- Who, when and How?
Myint, A. S., Dhadda, A., Stewart, A., Mills, J., Sripadam, R., Rao, C., . . . Gerard, J. P. (2023). The Role of Contact X-Ray Brachytherapy in Early Rectal Cancer- Who, when and How?. CLINICAL ONCOLOGY, 35(2), 87-96. doi:10.1016/j.clon.2022.10.003
Mouse organoids as an in vitro tool to study the in vivo intestinal response to cytotoxicants
Jardi, F., Kelly, C., Teague, C., Fowler-Williams, H., Sevin, D. C., Rodrigues, D., . . . Pritchard, D. M. (2023). Mouse organoids as an in vitro tool to study the in vivo intestinal response to cytotoxicants. ARCHIVES OF TOXICOLOGY, 97(1), 235-254. doi:10.1007/s00204-022-03374-3
2022
Homeostasis, injury and recovery dynamics at multiple scales in a self-organizing intestinal crypt
Endoscopic surveillance alone is feasible and safe in type I gastric neuroendocrine neoplasms less than 10mm in diameter
Exarchou, K., Hu, H., Stephens, N. A., Moore, A. R., Kelly, M., Lamarca, A., . . . Pritchard, D. M. (2022). Endoscopic surveillance alone is feasible and safe in type I gastric neuroendocrine neoplasms less than 10mm in diameter. In BRITISH JOURNAL OF SURGERY Vol. 109. doi:10.1093/bjs/znac404.040
Clinical prediction models assessing response to radiotherapy for rectal cancer: protocol for a systematic review.
Karageorgou, M., Hughes, D. M., Myint, A. S., Pritchard, D. M., & Bonnett, L. J. (2022). Clinical prediction models assessing response to radiotherapy for rectal cancer: protocol for a systematic review.. Diagnostic and prognostic research, 6(1), 19. doi:10.1186/s41512-022-00132-y
Endoscopic surveillance alone is feasible and safe in type I gastric neuroendocrine neoplasms less than 10 mm in diameter
Exarchou, K., Hu, H., Stephens, N. A., Moore, A. R., Kelly, M., Lamarca, A., . . . Pritchard, D. M. (2022). Endoscopic surveillance alone is feasible and safe in type I gastric neuroendocrine neoplasms less than 10 mm in diameter. ENDOCRINE, 78(1), 186-196. doi:10.1007/s12020-022-03143-3
Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa
Papoutsopoulou, S., Tang, J., Elramli, A. H., Williams, J. M., Gupta, N., Ikuomola, F. I., . . . Pritchard, D. M. (2022). Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa. American Journal of Physiology: Gastrointestinal and Liver Physiology, 323(4), G306-G317. doi:10.1152/ajpgi.00037.2022
New hope from OPERA trial for surgically fit rectal cancer patients who wish to have organ preservation.
Myint, A. S., Dhadda, A. S., Stewart, A., Mills, J., Sripadam, R., Rao, C., . . . Gerard, J. P. (2022). New hope from OPERA trial for surgically fit rectal cancer patients who wish to have organ preservation.. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. doi:10.1111/codi.16286
Regulation and Function of Matrix Metalloproteinase-13 in Cancer Progression and Metastasis
Li, S., Pritchard, D. M., & Yu, L. -G. (2022). Regulation and Function of Matrix Metalloproteinase-13 in Cancer Progression and Metastasis. CANCERS, 14(13). doi:10.3390/cancers14133263
Myths and misconceptions in the management of <i>Helicobacter pylori</i> infection
Bornschein, J., & Pritchard, D. M. (2022). Myths and misconceptions in the management of <i>Helicobacter pylori</i> infection. FRONTLINE GASTROENTEROLOGY, 13(3), 245-253. doi:10.1136/flgastro-2021-101826
New Developments in Gastric Neuroendocrine Neoplasms
Exarchou, K., Stephens, N. A., Moore, A. R., Howes, N. R., & Pritchard, D. M. (2022). New Developments in Gastric Neuroendocrine Neoplasms. Current Oncology Reports. doi:10.1007/s11912-021-01175-y
Neuroendocrine tumours: what gastroenterologists need to know
Khan, M. S., & Pritchard, D. M. (n.d.). Neuroendocrine tumours: what gastroenterologists need to know. Frontline Gastroenterology. doi:10.1136/flgastro-2020-101431
New Mouse Model Suggests That Some Neuroendocrine Tumors May Originate From Neural Crest-Derived Cells.
Pritchard, D. M. (2022). New Mouse Model Suggests That Some Neuroendocrine Tumors May Originate From Neural Crest-Derived Cells.. Cellular and molecular gastroenterology and hepatology, 14(5), 1170-1171. doi:10.1016/j.jcmgh.2022.08.005
2021
Genome-Wide association between EYA1 and Aspirin-induced peptic ulceration
Bourgeois, S., Carr, D. F., Musumba, C. O., Penrose, A., Esume, C., Morris, A. P., . . . Pirmohamed, M. (2021). Genome-Wide association between EYA1 and Aspirin-induced peptic ulceration. EBioMedicine, 74, 103728. doi:10.1016/j.ebiom.2021.103728
Effects of Proton Pump Inhibitor Therapy, H. pylori Infection and Gastric Preneoplastic Pathology on Fasting Serum Gastrin Concentrations
Veysey-Smith, R., Moore, A. R., Murugesan, S. V., Tiszlavicz, L., Dockray, G. J., Varro, A., & Pritchard, D. M. (2021). Effects of Proton Pump Inhibitor Therapy, <i>H</i>. <i>pylori</i> Infection and Gastric Preneoplastic Pathology on Fasting Serum Gastrin Concentrations. FRONTIERS IN ENDOCRINOLOGY, 12. doi:10.3389/fendo.2021.741887
British Society of Gastroenterology guidelines for the management of iron deficiency anaemia in adults
Snook, J., Bhala, N., Beales, I. L. P., Cannings, D., Kightley, C., Logan, R. P., . . . Goddard, A. F. (2021). British Society of Gastroenterology guidelines for the management of iron deficiency anaemia in adults. GUT, 70(11), 2030-2051. doi:10.1136/gutjnl-2021-325210
Is local excision sufficient in selected grade 1 or 2 type III gastric neuroendocrine neoplasms?
Exarchou, K., Kamieniarz, L., Tsoli, M., Victor, A., Oleinikov, K., Khan, M. S., . . . Toumpanakis, C. (2021). Is local excision sufficient in selected grade 1 or 2 type III gastric neuroendocrine neoplasms?. ENDOCRINE, 74(2), 421-429. doi:10.1007/s12020-021-02775-1
Gastric metastasis before diagnosis of primary invasive lobular breast carcinoma: a rare case presentation from Pakistan
Ali, M., Aziz, S., Ahmad, I., Saadia, A., Zahra, R., May, F. E. B., . . . Rasheed, F. (2021). Gastric metastasis before diagnosis of primary invasive lobular breast carcinoma: a rare case presentation from Pakistan. Women & Health, 1-5. doi:10.1080/03630242.2021.1981516
Appendiceal goblet cell carcinomas have poor survival despite completion surgery
Alabraba, E., Pritchard, D. M., Griffin, R., Diaz-Nieto, R., Banks, M., Cuthbertson, D. J., & Fenwick, S. (2021). Appendiceal goblet cell carcinomas have poor survival despite completion surgery. ENDOCRINE, 73(3), 734-744. doi:10.1007/s12020-021-02727-9
Appearance of peanut agglutinin in the blood circulation after peanut ingestion promotes endothelial secretion of metastasis-promoting cytokines
Wang, W., Sindrewicz-Goral, P., Chen, C., Duckworth, C. A., Pritchard, D. M., Rhodes, J. M., & Yu, L. -G. (2021). Appearance of peanut agglutinin in the blood circulation after peanut ingestion promotes endothelial secretion of metastasis-promoting cytokines. CARCINOGENESIS, 42(8), 1079-1088. doi:10.1093/carcin/bgab059
"Test-and-treat" strategy with urea breath test: A cost-effective approach for the management of Helicobacter pylori-related dyspepsia and the prevention of peptic ulcer in the United Kingdom-results of the Hp-Breath initiative
Pritchard, D. M., Bornschein, J., Beales, I. L. P., Salhi, H., Beresniak, A., & Malfertheiner, P. (2021). "Test-and-treat" strategy with urea breath test: A cost-effective approach for the management of Helicobacter pylori-related dyspepsia and the prevention of peptic ulcer in the United Kingdom-results of the Hp-Breath initiative. In HELICOBACTER Vol. 25 (pp. 3). Retrieved from http://gateway.webofknowledge.com/
A "Watch and Wait" Strategy Involving Regular Endoscopic Surveillance Is Safe for Many Patients with Small, Sporadic, Grade 1, Non-Ampullary, Non-Functioning Duodenal Neuroendocrine Tumours
Exarchou, K., Moore, A. R., Smart, H. L., Duckworth, C. A., Howes, N., & Pritchard, D. M. (2021). A "Watch and Wait" Strategy Involving Regular Endoscopic Surveillance Is Safe for Many Patients with Small, Sporadic, Grade 1, Non-Ampullary, Non-Functioning Duodenal Neuroendocrine Tumours. NEUROENDOCRINOLOGY, 111(8), 764-774. doi:10.1159/000511613
Cost-effectiveness modelling of use of urea breath test for the management of <i>Helicobacter pylori</i>-related dyspepsia and peptic ulcer in the UK
Pritchard, D. M., Bornschein, J., Beales, I., Beresniak, A., Salhi, H., & Malfertheiner, P. (2021). Cost-effectiveness modelling of use of urea breath test for the management of <i>Helicobacter pylori</i>-related dyspepsia and peptic ulcer in the UK. BMJ OPEN GASTROENTEROLOGY, 8(1). doi:10.1136/bmjgast-2021-000685
Oral Ferric Maltol Does Not Adversely Affect the Intestinal Microbiome of Patients or Mice, but Ferrous Sulphate Does
Mahalhal, A., Frau, A., Burkitt, M. D., Ijaz, U. Z., Lamb, C. A., Mansfield, J. C., . . . Probert, C. S. (2021). Oral Ferric Maltol Does Not Adversely Affect the Intestinal Microbiome of Patients or Mice, but Ferrous Sulphate Does. NUTRIENTS, 13(7). doi:10.3390/nu13072269
The Impact of <SUP>68</SUP>Gallium DOTA PET/CT in Managing Patients With Sporadic and Familial Pancreatic Neuroendocrine Tumours
Cuthbertson, D. J., Barriuso, J., Lamarca, A., Manoharan, P., Westwood, T., Jaffa, M., . . . Yip, V. S. (2021). The Impact of <SUP>68</SUP>Gallium DOTA PET/CT in Managing Patients With Sporadic and Familial Pancreatic Neuroendocrine Tumours. FRONTIERS IN ENDOCRINOLOGY, 12. doi:10.3389/fendo.2021.654975
IP1867B suppresses the Insulin-like Growth Factor 1 Receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas (Retraction of Vol 458, Pg 29, 2019)
Mihajluk, K., Simms, C., Reay, M., Madureira, P. A., Howarth, A., Murray, P., . . . Hill, R. (2021). IP1867B suppresses the Insulin-like Growth Factor 1 Receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas (Retraction of Vol 458, Pg 29, 2019). CANCER LETTERS, 507, 39. doi:10.1016/j.canlet.2021.03.008
The impact of lymph node metastases and right hemicolectomy on outcomes in appendiceal neuroendocrine tumours (aNETs).
Alabraba, E., Pritchard, D. M., Griffin, R., Diaz-Nieto, R., Banks, M., Cuthbertson, D. J., & Fenwick, S. (n.d.). The impact of lymph node metastases and right hemicolectomy on outcomes in appendiceal neuroendocrine tumours (aNETs).. Eur J Surg Oncol. doi:10.1016/j.ejso.2020.09.012
Long-Term Iron Deficiency and Dietary Iron Excess Exacerbate Acute Dextran Sodium Sulphate-Induced Colitis and Are Associated with Significant Dysbiosis
Mahalhal, A., Burkitt, M. D., Duckworth, C. A., Hold, G. L., Campbell, B. J., Pritchard, D. M., & Probert, C. S. (2021). Long-Term Iron Deficiency and Dietary Iron Excess Exacerbate Acute Dextran Sodium Sulphate-Induced Colitis and Are Associated with Significant Dysbiosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(7). doi:10.3390/ijms22073646
Nonlinear machine learning pattern recognition and bacteria-metabolite multilayer network analysis of perturbed gastric microbiome
Duran, C., Ciucci, S., Palladini, A., Ijaz, U. Z., Zippo, A. G., Sterbini, F. P., . . . Cannistraci, C. V. (2021). Nonlinear machine learning pattern recognition and bacteria-metabolite multilayer network analysis of perturbed gastric microbiome. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-22135-x
A clinical and scientific study to investigate the influence of statins on anastomotic healing in colorectal surgery
Battersby, C. (2021). A clinical and scientific study to investigate the influence of statins on anastomotic healing in colorectal surgery.
IRINOTECAN INDUCES A RAPID INCREASE IN ENTEROID PERMEABILITY
Turnbull, J. L., Lynch, S., Pritchard, D. M., Goldring, C. E. P., & Duckworth, C. A. (2021). IRINOTECAN INDUCES A RAPID INCREASE IN ENTEROID PERMEABILITY. In GUT Vol. 70 (pp. A177-A178). doi:10.1136/gutjnl-2020-bsgcampus.337
2020
Frequency and Causes of False-Positive Elevated Plasma Concentrations of Fasting Gut Hormones in a Specialist Neuroendocrine Tumor Center
Butler, O. L., Mekhael, M. M., Ahmed, A., Cuthbertson, D. J., & Pritchard, D. M. (n.d.). Frequency and Causes of False-Positive Elevated Plasma Concentrations of Fasting Gut Hormones in a Specialist Neuroendocrine Tumor Center. Frontiers in Endocrinology, 11. doi:10.3389/fendo.2020.606264
Carcinoid Heart Disease: Prognostic Value of 5-Hydroxyindoleacetic Acid Levels and Impact on Survival: A Systematic Literature Review
Buchanan-Hughes, A., Pashley, A., Feuilly, M., Marteau, F., Pritchard, D. M., & Singh, S. (2020). Carcinoid Heart Disease: Prognostic Value of 5-Hydroxyindoleacetic Acid Levels and Impact on Survival: A Systematic Literature Review. NEUROENDOCRINOLOGY, 111(1-2), 1-15. doi:10.1159/000506744
Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease
Lloyd, K., Papoutsopoulou, S., Smith, E., Stegmaier, P., Bergey, F., Morris, L., . . . Burkitt, M. D. (2020). Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease. DISEASE MODELS & MECHANISMS, 13(11). doi:10.1242/dmm.044040
NAP1L1: A Novel Human Colorectal Cancer Biomarker Derived From Animal Models of<i>Apc</i>Inactivation
Queiroz, C. J. S., Song, F., Reed, K. R., Al-Khafaji, N., Clarke, A. R., Vimalachandran, D., . . . Jenkins, J. R. (2020). NAP1L1: A Novel Human Colorectal Cancer Biomarker Derived From Animal Models of<i>Apc</i>Inactivation. FRONTIERS IN ONCOLOGY, 10. doi:10.3389/fonc.2020.01565
A Budget Impact Model of the Addition of Telotristat Ethyl Treatment to the Standard of Care in Patients with Uncontrolled Carcinoid Syndrome
Fust, K., Maschio, M., Kohli, M., Singh, S., Pritchard, D. M., Marteau, F., . . . Feuilly, M. (2020). A Budget Impact Model of the Addition of Telotristat Ethyl Treatment to the Standard of Care in Patients with Uncontrolled Carcinoid Syndrome. In PHARMACOECONOMICS Vol. 38 (pp. 607-618). doi:10.1007/s40273-020-00896-5
Systematic review: management of localised low-grade upper gastrointestinal neuroendocrine tumours
Exarchou, K., Howes, N., & Pritchard, D. M. (2020). Systematic review: management of localised low-grade upper gastrointestinal neuroendocrine tumours. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 51(12), 1247-1267. doi:10.1111/apt.15765
Machine learning pattern recognition and differential network analysis of gastric microbiome in the presence of proton pump inhibitor treatment or<i>Helicobacter pylori</i>infection
Risk factors and clinical correlates of neoplastic transformation in gastric hyperplastic polyps in Chinese patients
Hu, H., Zhang, Q., Chen, G., Pritchard, D. M., & Zhang, S. (2020). Risk factors and clinical correlates of neoplastic transformation in gastric hyperplastic polyps in Chinese patients. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-58900-z
IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas (vol 458C, pg 29, 2019)
Mihajluk, K., Simms, C., Reay, M., Madureira, P. A., Howarth, A., Murray, P., . . . Hill, R. (2020). IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas (vol 458C, pg 29, 2019). CANCER LETTERS, 469, 524-525. doi:10.1016/j.canlet.2019.10.002
Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors
Lloyd, K. A., Parsons, B. N., Burkitt, M. D., Moore, A. R., Papoutsopoulou, S., Boyce, M., . . . Pritchard, D. M. (2020). Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors. CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 10(1), 113-132. doi:10.1016/j.jcmgh.2020.01.010
Type III Gastric Neuroendocrine Neoplasms: Is Local Excision Sufficient in Selected Cases?
Exarchou, K., Kameniarz, L., Tsoli, M., Victor, A., Oleinikov, K., Khan, M., . . . Toumpanakis, C. (2020). Type III Gastric Neuroendocrine Neoplasms: Is Local Excision Sufficient in Selected Cases?. In NEUROENDOCRINOLOGY Vol. 110 (pp. 283). Retrieved from https://www.webofscience.com/
2019
Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research
Evans, J. P., Winiarski, B. K., Sutton, P. A., Ressel, L., Duckworth, C. A., Pritchard, D. M., . . . Kitteringham, N. R. (2019). Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research. LABORATORY ANIMALS, 53(6), 598-609. doi:10.1177/0023677219826165
NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells
Jones, L. G., Vaida, A., Thompson, L. M., Ikuomola, F. I., Caamaño, J. H., Burkitt, M. D., . . . Duckworth, C. A. (2019). NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells. Cell Death and Disease, 10. doi:10.1038/s41419-019-2129-5
Audit of the appropriateness and outcomes of 24-hour urinary 5-HIAA testing in a UK general hospital
Higginson, K., & Pritchard, D. M. (n.d.). Audit of the appropriateness and outcomes of 24-hour urinary 5-HIAA testing in a UK general hospital. Endocrine Abstracts. doi:10.1530/endoabs.68.p8
Frequency and causes of elevated fasting plasma concentrations of a panel of gut hormones in routine clinical practice
Butler, O., Mekhael, M., Ahmed, A., & Pritchard, D. M. (n.d.). Frequency and causes of elevated fasting plasma concentrations of a panel of gut hormones in routine clinical practice. Endocrine Abstracts. doi:10.1530/endoabs.68.p18
Type III gastric neuroendocrine neoplasms: moving towards less-extensive resections in selected cases?
Exarchou, K., Kameniarz, L., Victor, A., Khan, M., Srirajaskanthan, R., Mandair, D., . . . Toumpanakis, C. (n.d.). Type III gastric neuroendocrine neoplasms: moving towards less-extensive resections in selected cases?. Endocrine Abstracts. doi:10.1530/endoabs.68.p10
A novel FTIR analysis method for rapid high-confidence discrimination of esophageal cancer
Martin, D. S., Barrett, S., Weightman, P., & Smith, C. (2019). A novel FTIR analysis method for rapid high-confidence discrimination ofesophageal cancer. Infrared Physics and Technology, 102. doi:10.1016/j.infrared.2019.103007
Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients
Papoutsopoulou, S., Burkitt, M. D., Bergey, F., England, H., Hough, R., Schmidt, L., . . . Probert, C. S. (2019). Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients. FRONTIERS IN IMMUNOLOGY, 10. doi:10.3389/fimmu.2019.02168
British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma
Banks, M., Graham, D., Jansen, M., Gotoda, T., Coda, S., di Pietro, M., . . . Dinis-Ribeiro, M. (2019). British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma. GUT, 68(9), 1545-1575. doi:10.1136/gutjnl-2018-318126
IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas
Duckworth, C. A., Pritchard, D. M., Mihailuk, K., Simms, C., Reay, M., Madureira, P., . . . Hill, R. (2019). IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas. Cancer Letters. doi:10.1016/j.canlet.2019.05.028
Replication of Crohn's Disease Mucosal E. coli Isolates inside Macrophages Correlates with Resistance to Superoxide and Is Dependent on Macrophage NF-kappa B Activation
Tawfik, A., Knight, P., Duckworth, C. A., Pritchard, D. M., Rhodes, J. M., & Campbell, B. J. (2019). Replication of Crohn's Disease Mucosal E. coli Isolates inside Macrophages Correlates with Resistance to Superoxide and Is Dependent on Macrophage NF-kappa B Activation. PATHOGENS, 8(2). doi:10.3390/pathogens8020074
FERRIC MALTOL, UNLIKE FERROUS SULPHATE, DOES NOT ADVERSELY AFFECT THE INTESTINAL MICROBIOME
Mahalhal, A., Mansfield, J., Sampson, M., Lewis, S., Lamb, C., Frau, A., . . . Probert, C. (2019). FERRIC MALTOL, UNLIKE FERROUS SULPHATE, DOES NOT ADVERSELY AFFECT THE INTESTINAL MICROBIOME. In GUT Vol. 68 (pp. A84). doi:10.1136/gutjnl-2019-BSGAbstracts.161
RISK FACTORS AND CLINICAL CORRELATES OF NEOPLASTIC TRANSFORMATION IN GASTRIC HYPERPLASTIC POLYPSIN CHINESE PATIENTS
Hu, H., Zhang, Q., Chen, G., Pritchard, D. M., & Zhang, S. (2019). RISK FACTORS AND CLINICAL CORRELATES OF NEOPLASTIC TRANSFORMATION IN GASTRIC HYPERPLASTIC POLYPSIN CHINESE PATIENTS. In GUT Vol. 68 (pp. A102). doi:10.1136/gutjnl-2019-IDDFabstracts.193
Recharacterization data for a geriatric gastrin polycolonal antibody
Dodd, S., Varro, A., Pritchard, D. M., & Dockray, G. J. (2019). Recharacterization data for a geriatric gastrin polycolonal antibody. DATA IN BRIEF, 24. doi:10.1016/j.dib.2019.103886
Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration (vol 8, e2939, 2017)
Burkitt, M. D., Williams, J. M., Townsend, T., Hough, R., Duckworth, C. A., & Pritchard, D. M. (2019). Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration (vol 8, e2939, 2017). CELL DEATH & DISEASE, 10. doi:10.1038/s41419-019-1534-0
Long-term iron deficiency and iron supplementation exacerbate acute DSS-induced colitis and are associated with significant dysbiosis
Mahalhal, A., Burkitt, M., Duckworth, C., Hold, G., Campbell, B., Pritchard, M., & Probert, C. (2019). Long-term iron deficiency and iron supplementation exacerbate acute DSS-induced colitis and are associated with significant dysbiosis. doi:10.1101/585174
Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice
Reade, S., Williams, J. M., Aggio, R., Duckworth, C. A., Mahalhal, A., Hough, R., . . . Probert, C. S. (2019). Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice. FASEB JOURNAL, 33(3), 3129-3136. doi:10.1096/fj.201800076RR
A cohort study of local excision followed by adjuvant therapy incorporating a contact x- ray brachytherapy boost instead of radical resection in 180 patients with rectal cancer.
Smith, F. M., Pritchard, D. M., Wong, H., Whitmarsh, K., Hershman, M. J., & Sun Myint, A. (2019). A cohort study of local excision followed by adjuvant therapy incorporating a contact x- ray brachytherapy boost instead of radical resection in 180 patients with rectal cancer.. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. doi:10.1111/codi.14584
Macrophage-specific NF-κB activation dynamics can segregate inflammatory bowel disease patients
Papoutsopoulou, S., Burkitt, M., Bergey, F., England, H., Hough, R., Schmidt, L., . . . Probert, C. (2019). Macrophage-specific NF-κB activation dynamics can segregate inflammatory bowel disease patients. doi:10.1101/535096
Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.
Evans, J. P., Winiarski, B. K., Sutton, P. A., Jones, R. P., Ressel, L., Duckworth, C. A., . . . Kitteringham, N. R. (2019). Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.. Oncotarget, 10(6), 685. doi:10.18632/oncotarget.26625
Using systems medicine to identify a therapeutic agent with potential for repurposing in Inflammatory Bowel Disease
Endoscopic Surveillance Is a Viable Alternative Management Strategy for Patients with Localised Small Non-Functional Low Grade Duodenal Neuroendocrine Tumours (dNETs)
Exarchou, K., Howes, N., Moore, A., Duckworth, C. A., & Pritchard, D. M. (2019). Endoscopic Surveillance Is a Viable Alternative Management Strategy for Patients with Localised Small Non-Functional Low Grade Duodenal Neuroendocrine Tumours (dNETs). In NEUROENDOCRINOLOGY Vol. 108 (pp. 56). Retrieved from https://www.webofscience.com/
Endoscopic surveillance is a viable alternative management strategy for patients with localised small non-functional low grade duodenal neuroendocrine tumours (dNETs)
Exarchou, K., Howes, N., Moore, A., Duckworth, C. A., & Pritchard, D. M. (2019). Endoscopic surveillance is a viable alternative management strategy for patients with localised small non-functional low grade duodenal neuroendocrine tumours (dNETs). In BRITISH JOURNAL OF SURGERY Vol. 106 (pp. 74). Retrieved from https://www.webofscience.com/
Netazepide, a Gastrin/CCK2 Receptor Antagonist, Can Eradicate Gastric Neuroendocrine Tumours in PatientsWith Autoimmune Chronic Atrophic Gastritis
Boyce, M., Moore, A. R., Parsons, B., Lloyd, K., Sagatun, L., Varro, A., . . . Pritchard, D. M. (2019). Netazepide, a Gastrin/CCK2 Receptor Antagonist, Can Eradicate Gastric Neuroendocrine Tumours in PatientsWith Autoimmune Chronic Atrophic Gastritis. In PANCREAS Vol. 48 (pp. 429). Retrieved from https://www.webofscience.com/
Periodic endoscopic surveillance in patients with low risk Type 1 gastric neuroendocrine tumours (gNETs) also detects associated gastric adenocarcinoma in a subset of patients
Exarchou, K., Howes, N., Moore, A., Duckworth, C., & Pritchard, D. M. (2019). Periodic endoscopic surveillance in patients with low risk Type 1 gastric neuroendocrine tumours (gNETs) also detects associated gastric adenocarcinoma in a subset of patients. In BRITISH JOURNAL OF SURGERY Vol. 106 (pp. 85). Retrieved from https://www.webofscience.com/
2018
Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell
Smith, C. I., Siggel-King, M. R. F., Ingham, J., Harrison, P., Martin, D. S., Varro, A., . . . Weightman, P. (2018). Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell. ANALYST, 143(24), 5912-5917. doi:10.1039/c8an01183d
The impact of 68Ga-based PET-CT scanning on the management of patients with sporadic pancreatic neuroendocrine tumours (pNETs)
Cuthbertson, D., Barriuso, J., Pizanais, M., Jaffa, M., Lamarca, A., Vivian, G., . . . Yip, V. (n.d.). The impact of 68Ga-based PET-CT scanning on the management of patients with sporadic pancreatic neuroendocrine tumours (pNETs). Endocrine Abstracts. doi:10.1530/endoabs.60.p18
Submicron infrared imaging of an oesophageal cancer cell with chemical specificity using an IR-FEL
Ingham, J., Craig, T., Smith, C. I., Varro, A., Pritchard, D. M., Barrett, S. D., . . . Siggel-King, M. R. F. (2018). Submicron infrared imaging of an oesophageal cancer cell with chemical specificity using an IR-FEL. Biomedical Physics and Engineering Express, 5. doi:10.1088/2057-1976/aaea53
Oral iron exacerbates colitis and influences the intestinal microbiome
Mahalhal, A., Williams, J. M., Johnson, S., Ellaby, N., Duckworth, C. A., Burkitt, M. D., . . . Probert, C. S. (2018). Oral iron exacerbates colitis and influences the intestinal microbiome. PLOS ONE, 13(10). doi:10.1371/journal.pone.0202460
Contact X-ray Brachytherapy as an Adjunct to a Watch and Wait Approach is an Affordable Alternative to Standard Surgical Management of Rectal Cancer for Patients with a Partial Clinical Response to Chemoradiotherapy
Rao, C., Stewartz, A., Martin, A. P., Collins, B., Pritchard, D. M., Athanasiou, T., & Myint, A. S. (2018). Contact X-ray Brachytherapy as an Adjunct to a Watch and Wait Approach is an Affordable Alternative to Standard Surgical Management of Rectal Cancer for Patients with a Partial Clinical Response to Chemoradiotherapy. CLINICAL ONCOLOGY, 30(10), 625-633. doi:10.1016/j.clon.2018.06.010
Oral iron exacerbates colitis and influences the intestinal microbiome
Mahalhal, A., Williams, J., Johnson, S., Ellaby, N., Duckworth, C., Burkitt, M., . . . Probert, C. (2018). Oral iron exacerbates colitis and influences the intestinal microbiome. doi:10.1101/385997
Contact X-Ray Brachytherapy in Organ Preservation for Rectal Cancer Reply
Myint, A. S., Smith, F. M., Gollins, S., Rao, C., & Pritchard, D. M. (2018). Contact X-Ray Brachytherapy in Organ Preservation for Rectal Cancer Reply. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 101(3), 743-744. doi:10.1016/j.ijrobp.2018.03.033
The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer
Evans, J. P., Winiarski, B. K., Sutton, P. A., Jones, R. P., Ressel, L., Duckworth, C. A., . . . Kitteringham, N. R. (2018). The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer. Oncotarget, 9(43), 27104-27116. doi:10.18632/oncotarget.25497
IDENTIFICATION OF A NOVEL THERAPEUTIC AGENT FOR TREATING IBD GUIDED BY SYSTEMS MEDICINE
Burkitt, M., Lloyd, K., Papoutsopoulou, S., Smith, E., Stegmaier, P., Pritchard, D. M., . . . Probert, C. (2018). IDENTIFICATION OF A NOVEL THERAPEUTIC AGENT FOR TREATING IBD GUIDED BY SYSTEMS MEDICINE. In GUT Vol. 67 (pp. A52). doi:10.1136/gutjnl-2018-BSGAbstracts.104
INTESTINAL DYSBIOSIS OCCURS IN IRON DEFICIENCY AS WELL AS ACTIVE IBD
Mahalhal, A., Subramanian, S., Pritchard, D. M., & Probert, C. S. (2018). INTESTINAL DYSBIOSIS OCCURS IN IRON DEFICIENCY AS WELL AS ACTIVE IBD. In GUT Vol. 67 (pp. A193). doi:10.1136/gutjnl-2018-BSGAbstracts.384
Matrix metalloproteinase (MMP)-7 in Barrett's esophagus and esophageal adenocarcinoma: expression, metabolism, and functional significance
Garalla, H. M., Lertkowit, N., Tiszlavicz, L., Reisz, Z., Holmberg, C., Beynon, R., . . . Varro, A. (2018). Matrix metalloproteinase (MMP)-7 in Barrett's esophagus and esophageal adenocarcinoma: expression, metabolism, and functional significance. Retrieved from https://www.webofscience.com/
SNOM Imaging of a Crypt-Like Feature in Adenocarcinoma Associated with Barrett's Oesophagus
Craig, T., Smith, A. D., Holder, G. M., Ingham, J., Smith, C. I., Varro, A., . . . Siggel-King, M. R. F. (2018). SNOM Imaging of a Crypt-Like Feature in Adenocarcinoma Associated with Barrett's Oesophagus. PHYSICA STATUS SOLIDI B-BASIC SOLID STATE PHYSICS, 255(4). doi:10.1002/pssb.201700518
An evaluation of the application of the aperture infrared SNOM technique to biomedical imaging
Ingham, J., Pilling, M. J., Craig, T., Siggel-King, M. R. F., Smith, C. I., Gardner, P., . . . Weightman, P. (2018). An evaluation of the application of the aperture infrared SNOM technique to biomedical imaging. Biomedical Physics & Engineering Express, 4(2). doi:10.1088/2057-1976/aaa0de
Dose Escalation Using Contact X-ray Brachytherapy After External Beam Radiotherapy as Nonsurgical Treatment Option for Rectal Cancer: Outcomes From a Single-Center Experience
Myint, A. S., Smith, F. M., Gollins, S., Wong, H., Rao, C., Whitmarsh, K., . . . Pritchard, D. M. (2018). Dose Escalation Using Contact X-ray Brachytherapy After External Beam Radiotherapy as Nonsurgical Treatment Option for Rectal Cancer: Outcomes From a Single-Center Experience. International Journal of Radiation: Oncology - Biology - Physics, 100(3), 565-573. doi:10.1016/j.ijrobp.2017.10.022
<SUP>68</SUP>Gallium DOTANOC-PET Imaging in Lung Carcinoids: Impact on Patients' Management
Lamarca, A., Pritchard, D. M., Westwood, T., Papaxoinis, G., Nonaka, D., Vinjamuri, S., . . . Mansoor, W. (2018). <SUP>68</SUP>Gallium DOTANOC-PET Imaging in Lung Carcinoids: Impact on Patients' Management. NEUROENDOCRINOLOGY, 106(2), 128-138. doi:10.1159/000472717
Factors regulating cell shedding in mouse and rat small intestine
Elramli, A. H. (2018). Factors regulating cell shedding in mouse and rat small intestine.
2017
Comparison Of The Human Gastric Microbiota In Hypochlorhydric States Arising As A Result Of Helicobacter pylori-Induced Atrophic Gastritis, Autoimmune Atrophic Gastritis And Proton Pump Inhibitor Use
parsons, B. N., Ijaz, U. Z., D'Amore, R., Burkitt, M. D., Eccles, R., Lenzi, L., . . . Pritchard, D. M. (2017). Comparison Of The Human Gastric Microbiota In Hypochlorhydric States Arising As A Result Of Helicobacter pylori-Induced Atrophic Gastritis, Autoimmune Atrophic Gastritis And Proton Pump Inhibitor Use. PLoS Pathogens. doi:10.1101/144907
Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use
Parsons, B. N., Ijaz, U. Z., D'Amore, R., Burkitt, M. D., Eccles, R., Lenzi, L., . . . Pritchard, D. M. (2017). Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use. PLoS Pathogens, 13(11). doi:10.1371/journal.ppat.1006653
Quality standards in upper gastrointestinal endoscopy: a position statement of the British Society of Gastroenterology (BSG) and Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland (AUGIS)
Beg, S., Ragunath, K., Wyman, A., Banks, M., Trudgill, N., Pritchard, M. D., . . . Veitch, A. (2017). Quality standards in upper gastrointestinal endoscopy: a position statement of the British Society of Gastroenterology (BSG) and Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland (AUGIS). GUT, 66(11), 1886-1899. doi:10.1136/gutjnl-2017-314109
Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration
Burkitt, M. D., Williams, J. M., Townsend, T., Hough, R., & Pritchard, D. M. (2017). Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration. CELL DEATH & DISEASE, 8. doi:10.1038/cddis.2017.332
Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration.
Burkitt, M., Williams, J., Townsend, T., Hough, R., Duckworth, C., & Pritchard, D. M. (2017). Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration.. Cell Death and Disease. doi:10.1101/112656
EXPRESSION OF MADCAM-1 IN THE UPPER GASTROINTESTINAL TRACT: IS THERE A ROLE FOR DISRUPTING INTERACTIONS BETWEEN MADCAM-1 AND ALPHA-4/BETA-7 INTEGRIN IN UPPER GI CROHN'S DISEASE?
Ahmed, A., Pritchard, D. M., & Burkitt, M. D. (2017). EXPRESSION OF MADCAM-1 IN THE UPPER GASTROINTESTINAL TRACT: IS THERE A ROLE FOR DISRUPTING INTERACTIONS BETWEEN MADCAM-1 AND ALPHA-4/BETA-7 INTEGRIN IN UPPER GI CROHN'S DISEASE?. In GUT Vol. 66 (pp. A236). doi:10.1136/gutjnl-2017-314472.459
INFECTION WITH STREPTOCOCCUS GALLOLYTICUS INCREASES APOPTOSIS IN THE MURINE COLON
Townsend, T., Burkitt, M., & Pritchard, D. M. (2017). INFECTION WITH STREPTOCOCCUS GALLOLYTICUS INCREASES APOPTOSIS IN THE MURINE COLON. In GUT Vol. 66 (pp. A135). doi:10.1136/gutjnl-2017-314472.265
INFLUENCE OF IRON ON GUT MICROBIAL COMPOSITION IN ACUTE DSS-INDUCED COLITIS IN C57BL/6 MICE
Mahalhal, A., Campbell, B., Pritchard, D. M., & Probert, C. (2017). INFLUENCE OF IRON ON GUT MICROBIAL COMPOSITION IN ACUTE DSS-INDUCED COLITIS IN C57BL/6 MICE. In GUT Vol. 66 (pp. A234). doi:10.1136/gutjnl-2017-314472.456
LONGITUDINAL INVESTIGATION OF MICROBIOTA DYNAMICS IN A MODEL OF MILD CHRONIC DSSINDUCED COLITIS IN WILD-TYPE (WT) C57BL/6 MICE RECEIVING DIETS WITH DIFFERENT IRON CONTENTS
Mahalhal, A., Campbell, B., Pritchard, D. M., & Probert, C. (2017). LONGITUDINAL INVESTIGATION OF MICROBIOTA DYNAMICS IN A MODEL OF MILD CHRONIC DSSINDUCED COLITIS IN WILD-TYPE (WT) C57BL/6 MICE RECEIVING DIETS WITH DIFFERENT IRON CONTENTS. In GUT Vol. 66 (pp. A237). doi:10.1136/gutjnl-2017-314472.463
Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury
Carr, D. F., Ayehunie, S., Davies, A., Duckworth, C. A., French, S., Hall, N., . . . Pirmohamed, M. (2017). Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury. PHARMACOLOGY & THERAPEUTICS, 172, 181-194. doi:10.1016/j.pharmthera.2017.01.002
Hexane Extracts of Calophyllum brasiliense Inhibit the Development of Gastric Preneoplasia in Helicobacter felis Infected INS-Gas Mice
Lemos, L. M. S., Miyajima, F., Castilho, G. R. C., Martins, D. T. O., Pritchard, D. M., & Burkitt, M. D. (2017). Hexane Extracts of Calophyllum brasiliense Inhibit the Development of Gastric Preneoplasia in Helicobacter felis Infected INS-Gas Mice. Frontiers in Pharmacology, 8. doi:10.3389/fphar.2017.00092
<i>Helicobacter pylori</i>-induced gastric pathology: insights from <i>in vivo</i> and ex <i>vivo</i> models
Burkitt, M. D., Duckworth, C. A., Williams, J. M., & Pritchard, D. M. (2017). <i>Helicobacter pylori</i>-induced gastric pathology: insights from <i>in vivo</i> and ex <i>vivo</i> models. DISEASE MODELS & MECHANISMS, 10(2), 89-104. doi:10.1242/dmm.027649
Dose escalation using contact X-ray brachytherapy (Papillon) for rectal cancer: does it improve the chance of organ preservation?
Myint, A. S., Smith, F. M., Gollins, S. W., Wong, H., Rao, C., Whitmarsh, K., . . . Pritchard, D. M. (2017). Dose escalation using contact X-ray brachytherapy (Papillon) for rectal cancer: does it improve the chance of organ preservation?. BRITISH JOURNAL OF RADIOLOGY, 90(1080). doi:10.1259/bjr.20170175
Influence of iron supplementation on gut microbiota and the natural history of inflammatory bowel disease
Mahalhal, A. (2017). Influence of iron supplementation on gut microbiota and the natural history of inflammatory bowel disease.
Investigation of the importance of intestinal epithelial cell specific nuclear factor-κB subunits in regulating the response to intestinal damage-inducing stimuli
James, S. (2017). Investigation of the importance of intestinal epithelial cell specific nuclear factor-κB subunits in regulating the response to intestinal damage-inducing stimuli.
Validation of novel colorectal cancer biomarkers derived from animal models of Apc inactivation : analysis of cohorts from the UK and Brazil
Queiroz, C. J. (2017). Validation of novel colorectal cancer biomarkers derived from animal models of Apc inactivation : analysis of cohorts from the UK and Brazil.
2016
Potential clinical indications for a CCK2 receptor antagonist.
Boyce, M., Lloyd, K. A., & Pritchard, D. M. (2016). Potential clinical indications for a CCK<sub>2</sub> receptor antagonist. CURRENT OPINION IN PHARMACOLOGY, 31, 68-75. doi:10.1016/j.coph.2016.09.002
68Gallium-DOTANOC (68Ga-DOTANOC) positron emission tomography (PET) imaging in Bronchial Carcinoids (BC): multicentre evaluation of its role in clinical practice
Lamarca, A., Pritchard, D. M., Westwood, T., Papaxoinis, G., Vinjamuri, S., Valle, J. W., . . . Mansoor, W. (n.d.). 68Gallium-DOTANOC (68Ga-DOTANOC) positron emission tomography (PET) imaging in Bronchial Carcinoids (BC): multicentre evaluation of its role in clinical practice. Endocrine Abstracts. doi:10.1530/endoabs.46.p2
A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies.
Calvete, O., Varro, A., Pritchard, D. M., Barroso, A., Oteo, M., Morcillo, M., . . . Benitez, J. (2016). A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies.. Disease models & mechanisms, 9(9), 975-984. doi:10.1242/dmm.025890
Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27(kip1)
Lloyd, K. A., Moore, A. R., Parsons, B. N., O'Hara, A., Boyce, M., Dockray, G. J., . . . Pritchard, D. M. (2016). Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27(kip1). ONCOTARGET, 7(29), 45462-45478. doi:10.18632/oncotarget.9990
Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis
Merga, Y. J., O Hara, A., Burkitt, M. D., Duckworth, C. A., Probert, C. S., Campbell, B. J., & Pritchard, D. M. (2016). Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis. American Journal of Physiology - Gastrointestinal and Liver Physiology, 310(11), G1081-G1090. doi:10.1152/ajpgi.00026.2016
Intestinal Preparation Techniques for Histological Analysis in the Mouse.
Williams, J. M., Duckworth, C. A., Vowell, K., Burkitt, M. D., & Pritchard, D. M. (2016). Intestinal Preparation Techniques for Histological Analysis in the Mouse.. Current protocols in mouse biology, 6(2), 148-168. doi:10.1002/cpmo.2
Letter: gastric cancer and pernicious anaemia - only a minority of UK pernicious anaemia patients have had a gastroscopy
Pritchard, D. M., & Hooper, M. (2016). Letter: gastric cancer and pernicious anaemia - only a minority of UK pernicious anaemia patients have had a gastroscopy. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 43(10), 1106-1107. doi:10.1111/apt.13595
Clinical pharmacology of netazepide, a gastrin/CCK-2 receptor antagonist
Boyce, M. J. (2016). Clinical pharmacology of netazepide, a gastrin/CCK-2 receptor antagonist.
Netazepide, a Gastrin/CCK2 Receptor Antagonist, Can Eradicate Gastric Neuroendocrine Tumours in Patients with Autoimmune Chronic Atrophic Gastritis
Boyce, M., Moore, A. R., Parsons, B. N., Lloyd, K. A., Sagatun, L., Thomsen, L., . . . Pritchard, D. M. (2016). Netazepide, a Gastrin/CCK2 Receptor Antagonist, Can Eradicate Gastric Neuroendocrine Tumours in Patients with Autoimmune Chronic Atrophic Gastritis. In NEUROENDOCRINOLOGY Vol. 103 (pp. 78). Retrieved from https://www.webofscience.com/
2015
The stomach in health and disease
Hunt, R. H., Camilleri, M., Crowe, S. E., El-Omar, E. M., Fox, J. G., Kuipers, E. J., . . . Tack, J. (2015). The stomach in health and disease. GUT, 64(10), 1650-1668. doi:10.1136/gutjnl-2014-307595
Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis
Duckworth, C. A., Guimond, S. E., Sindrewicz, P., Hughes, A. J., French, N. S., Lian, L. -Y., . . . Yu, L. -G. (2015). Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis. ONCOTARGET, 6(27), 23671-23687. doi:10.18632/oncotarget.4409
bak deletion stimulates gastric epithelial proliferation and enhances <i>Helicobacter felis</i>-induced gastric atrophy and dysplasia in mice
Duckworth, C. A., Abuderman, A. A., Burkitt, M. D., Williams, J. M., O'Reilly, L. A., & Pritchard, D. M. (2015). bak deletion stimulates gastric epithelial proliferation and enhances <i>Helicobacter felis</i>-induced gastric atrophy and dysplasia in mice. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 309(6), G420-G430. doi:10.1152/ajpgi.00404.2014
Helicobacter pylori, HIV and Gastric Hypochlorhydria in the Malawian Population
Geraghty, J., Thumbs, A., Kankwatira, A., Andrews, T., Moore, A., Malamba, R., . . . Gordon, M. (2015). Helicobacter pylori, HIV and Gastric Hypochlorhydria in the Malawian Population. PloS One, 10(8). doi:10.1371/journal.pone.0132043
PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation
Dammann, K., Khare, V., Lang, M., Claudel, T., Harpain, F., Granofszky, N., . . . Gasche, C. (2015). PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. In CANCER RESEARCH Vol. 75. doi:10.1158/1538-7445.AM2015-137
Gastrin stimulates MMP-1 expression in gastric epithelial cells: putative role in gastric epithelial cell migration
Kumar, J. D., Steele, I., Moore, A. R., Murugesan, S. V., Rakonczay, Z., Venglovecz, V., . . . Dockray, G. J. (2015). Gastrin stimulates MMP-1 expression in gastric epithelial cells: putative role in gastric epithelial cell migration. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 309(2), G78-G86. doi:10.1152/ajpgi.00084.2015
NF-kappaB1, NF-kappaB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice
Burkitt, M., Hanedi, A. F., Duckworth, C., Williams, J. M., Tang, J. M., O'Reilly, L. A., . . . Pritchard, M. (2015). NF-kappaB1, NF-kappaB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice. The Journal of Pathology, 236(3), 326-336. doi:10.1002/path.4527
CONFOCAL ENDOMICROSCOPY DEMONSTRATES INCREASED INTESTINAL PERMEABILITY AND GUT DYSFUNCTION IN PATIENTS WITH ACUTE AND CHRONIC PANCREATITIS
Bharucha, S., Geraghty, J., Duckworth, C., Armstrong, J., Szatmary, P., Winn, S., . . . Sutton, R. (2015). CONFOCAL ENDOMICROSCOPY DEMONSTRATES INCREASED INTESTINAL PERMEABILITY AND GUT DYSFUNCTION IN PATIENTS WITH ACUTE AND CHRONIC PANCREATITIS. In GUT Vol. 64 (pp. A307). doi:10.1136/gutjnl-2015-309861.663
Murine Models of Helicobacter (pylori or felis)-associated Gastric Cancer.
Duckworth, C. A., Burkitt, M. D., Williams, J. M., Parsons, B. N., Tang, J. M. F., & Pritchard, D. M. (2015). Murine Models of Helicobacter (pylori or felis)-associated Gastric Cancer.. Current protocols in pharmacology, 69, 14.34.1-14.34.35. doi:10.1002/0471141755.ph1434s69
OC-043 Nfkb1 deficiency alters susceptibility to helicobacter spp. induced il-1Β secretion in bone marrow derived dendritic cells
Tang, J. M., Pritchard, D. M., Duckworth, C. A., Caamano, J., & Burkitt, M. D. (2015). OC-043 Nfkb1 deficiency alters susceptibility to helicobacter spp. induced il-1Β secretion in bone marrow derived dendritic cells. Gut, 64(Suppl 1), A22.2-A23. doi:10.1136/gutjnl-2015-309861.43
VOLATILE ORGANIC COMPOUND (VOC) PROFILES AS INDICATORS OF EARLY LESIONS IN MURINE COLON CARCINOGENESIS
Reade, S., Williams, J. M., Pritchard, D. M., & Probert, C. S. J. (2015). VOLATILE ORGANIC COMPOUND (VOC) PROFILES AS INDICATORS OF EARLY LESIONS IN MURINE COLON CARCINOGENESIS. In GUT Vol. 64 (pp. A374-A375). doi:10.1136/gutjnl-2015-309861.819
Exome sequencing identifies ATP4A gene as responsible of an atypical familial type I gastric neuroendocrine tumour
Calvete, O., Reyes, J., Zuniga, S., Paumard-Hernandez, B., Fernandez, V., Bujanda, L., . . . Benitez, J. (2015). Exome sequencing identifies ATP4A gene as responsible of an atypical familial type I gastric neuroendocrine tumour. Human Molecular Genetics, 24(10), 2914-2922. doi:10.1093/hmg/ddv054
Epithelial Cell Shedding and Barrier Function: A Matter of Life and Death at the Small Intestinal Villus Tip
Williams, J. M., Duckworth, C. A., Burkitt, M. D., Watson, A. J. M., Campbell, B. J., & Pritchard, D. M. (2015). Epithelial Cell Shedding and Barrier Function: A Matter of Life and Death at the Small Intestinal Villus Tip. VETERINARY PATHOLOGY, 52(3), 445-455. doi:10.1177/0300985814559404
242 A Combination of Fasting Serum Gastrin Concentration, Pepsinogen 1/2 Ratio and Helicobacter pylori IgG Antibody Serotype Accurately Predicts Gastric Mucosal Preneoplasia in a Large European Cohort
Moore, A. R., Steele, I., Murugesan, S. V., Tiszlavicz, L., Dockray, G. J., Varro, A., & Pritchard, D. M. (2015). 242 A Combination of Fasting Serum Gastrin Concentration, Pepsinogen 1/2 Ratio and Helicobacter pylori IgG Antibody Serotype Accurately Predicts Gastric Mucosal Preneoplasia in a Large European Cohort. Gastroenterology, 148(4), S-54. doi:10.1016/s0016-5085(15)30187-6
25 Intestinal Epithelial Cell Specific Deletion of Nfkb2 Protects Against Immune Cell Derived Damage-Inducing Factors in an Enteroid and Bone Marrow Derived Dendritic Cell Co-Culture System
Burkitt, M. D., Jones, L. G., Caamano, J., Pritchard, D. M., & Duckworth, C. A. (2015). 25 Intestinal Epithelial Cell Specific Deletion of Nfkb2 Protects Against Immune Cell Derived Damage-Inducing Factors in an Enteroid and Bone Marrow Derived Dendritic Cell Co-Culture System. Gastroenterology, 148(4). doi:10.1016/s0016-5085(15)30025-1
606 NFKB1 Deficiency Alters Susceptibility to Helicobacter spp. Induced IL-1β Secretion in Bone Marrow Derived Dendritic Cells
Tang, J. M., Duckworth, C. A., Pritchard, D. M., Caamano, J., & Burkitt, M. D. (2015). 606 NFKB1 Deficiency Alters Susceptibility to Helicobacter spp. Induced IL-1β Secretion in Bone Marrow Derived Dendritic Cells. Gastroenterology, 148(4), S-118. doi:10.1016/s0016-5085(15)30409-1
760 Confocal Endomicroscopy Demonstrates Increased Intestinal Permeability and Gut Dysfunction in Patients With Acute and Chronic Pancreatitis
Bharucha, S., Geraghty, J., Duckworth, C. A., Armstrong, J., Szatmary, P., Winn, S. A., . . . Sutton, R. (2015). 760 Confocal Endomicroscopy Demonstrates Increased Intestinal Permeability and Gut Dysfunction in Patients With Acute and Chronic Pancreatitis. Gastroenterology, 148(4), S-145. doi:10.1016/s0016-5085(15)30495-9
Sa1821 Gastrin Increases miR-222 Expression in AGSGR Cells In Vitro and in the Stomachs of Hypergastrinemic INS-GAS Mice and Humans In Vivo via Activation of the CCK2 Receptor
Lloyd, K. A., Moore, A. R., O'Hara, A., Boyce, M. J., Varro, A., & Pritchard, D. M. (2015). Sa1821 Gastrin Increases miR-222 Expression in AGSGR Cells In Vitro and in the Stomachs of Hypergastrinemic INS-GAS Mice and Humans In Vivo via Activation of the CCK2 Receptor. Gastroenterology, 148(4), S-341. doi:10.1016/s0016-5085(15)31137-9
Sa1824 Identification of Potential Biomarkers of Netazepide (YF476) Treatment of Type I Gastric Neuroendocrine Tumours
Moore, A. R., Parsons, B. N., Boyce, M. J., Rainbow, L., Fang, Y., Varro, A., . . . Pritchard, D. M. (2015). Sa1824 Identification of Potential Biomarkers of Netazepide (YF476) Treatment of Type I Gastric Neuroendocrine Tumours. Gastroenterology, 148(4), S-342. doi:10.1016/s0016-5085(15)31140-9
Su1927 Passive Transmission of Helicobacter felis Occurs in a Specific Pathogen Free (SPF) Laboratory Environment
Tang, J. M., Parsons, B. N., Williams, J. M., Pritchard, D. M., & Burkitt, M. D. (2015). Su1927 Passive Transmission of Helicobacter felis Occurs in a Specific Pathogen Free (SPF) Laboratory Environment. Gastroenterology, 148(4), S-553. doi:10.1016/s0016-5085(15)31857-6
Su1973 Tamoxifen Induced Gastric Atrophy Is Regulated by the NF-κB Subunit NFKB1
Williams, J. M., Norman, R., Tang, J. M., Caamano, J., Duckworth, C. A., Pritchard, D. M., & Burkitt, M. D. (2015). Su1973 Tamoxifen Induced Gastric Atrophy Is Regulated by the NF-κB Subunit NFKB1. Gastroenterology, 148(4), S-565. doi:10.1016/s0016-5085(15)31902-8
<i>NFKB1</i> Deficiency Alters Susceptibility to <i>Helicobacter spp</i>. Induced IL-1β Secretion in Bone Marrow Derived Dendritic Cells
Tang, J. M., Duckworth, C. A., Pritchard, D. M., Caamano, J., & Burkitt, M. D. (2015). <i>NFKB1</i> Deficiency Alters Susceptibility to <i>Helicobacter spp</i>. Induced IL-1β Secretion in Bone Marrow Derived Dendritic Cells. In GASTROENTEROLOGY Vol. 148 (pp. S118). Retrieved from https://www.webofscience.com/
A Combination of Fasting Serum Gastrin Concentration, Pepsinogen 1/2 Ratio and <i>Helicobacter pylori</i> IgG Antibody Serotype Accurately Predicts Gastric Mucosal Preneoplasia in a Large European Cohort
Moore, A. R., Steele, I., Murugesan, S. V., Tiszlavicz, L., Dockray, G. J., Varro, A., & Pritchard, D. M. (2015). A Combination of Fasting Serum Gastrin Concentration, Pepsinogen 1/2 Ratio and <i>Helicobacter pylori</i> IgG Antibody Serotype Accurately Predicts Gastric Mucosal Preneoplasia in a Large European Cohort. In GASTROENTEROLOGY Vol. 148 (pp. S54). Retrieved from https://www.webofscience.com/
Confocal Endomicroscopy Demonstrates Increased Intestinal Permeability and Gut Dysfunction in Patients With Acute and Chronic Pancreatitis
Bharucha, S., Geraghty, J., Duckworth, C. A., Armstrong, J., Szatmary, P., Winn, S. A., . . . Sutton, R. (2015). Confocal Endomicroscopy Demonstrates Increased Intestinal Permeability and Gut Dysfunction in Patients With Acute and Chronic Pancreatitis. In GASTROENTEROLOGY Vol. 148 (pp. S145). Retrieved from https://www.webofscience.com/
Gastrin Increases miR-222 Expression in AGS<sub>GR</sub> Cells <i>In Vitro</i> and in the Stomachs of Hypergastrinemic INS-GAS Mice and Humans <i>In Vivo</i> via Activation of the CCK2 Receptor
Lloyd, K. A., Moore, A. R., O'Hara, A., Boyce, M. J., Varro, A., & Pritchard, D. M. (2015). Gastrin Increases miR-222 Expression in AGS<sub>GR</sub> Cells <i>In Vitro</i> and in the Stomachs of Hypergastrinemic INS-GAS Mice and Humans <i>In Vivo</i> via Activation of the CCK2 Receptor. In GASTROENTEROLOGY Vol. 148 (pp. S341). Retrieved from https://www.webofscience.com/
Intestinal Epithelial Cell Specific Deletion of Nfkb2 Protects Against Immune Cell Derived Damage-Inducing Factors in an Enteroid and Bone Marrow Derived Dendritic Cell Co-Culture System
Burkitt, M. D., Jones, L. G., Caamano, J., Pritchard, D. M., & Duckworth, C. A. (2015). Intestinal Epithelial Cell Specific Deletion of Nfkb2 Protects Against Immune Cell Derived Damage-Inducing Factors in an Enteroid and Bone Marrow Derived Dendritic Cell Co-Culture System. In GASTROENTEROLOGY Vol. 148 (pp. S8-S9). Retrieved from https://www.webofscience.com/
Passive Transmission of <i>Helicobacter felis</i> Occurs in a Specific Pathogen Free (SPF) Laboratory Environment
Tang, J. M., Parsons, B. N., Williams, J. M., Pritchard, D. M., & Burkitt, M. D. (2015). Passive Transmission of <i>Helicobacter felis</i> Occurs in a Specific Pathogen Free (SPF) Laboratory Environment. In GASTROENTEROLOGY Vol. 148 (pp. S553). Retrieved from https://www.webofscience.com/
Polymorphisms in the <i>RELB</i> Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy
O'Hara, A., Burkitt, M. D., Carr, D. F., Alfirevic, A., Moore, A. R., Murugesan, S. V., . . . Pritchard, D. M. (2015). Polymorphisms in the <i>RELB</i> Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy. In GASTROENTEROLOGY Vol. 148 (pp. S566). Retrieved from https://www.webofscience.com/
Tamoxifen Induced Gastric Atrophy Is Regulated by the NF-κB Subunit NFKB1
Williams, J. M., Norman, R., Tang, J. M., Caamano, J., Duckworth, C. A., Pritchard, D. M., & Burkitt, M. D. (2015). Tamoxifen Induced Gastric Atrophy Is Regulated by the NF-κB Subunit NFKB1. In GASTROENTEROLOGY Vol. 148 (pp. S565). Retrieved from https://www.webofscience.com/
2014
Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galactin-3 to promote metastasis by interaction with cancer-associated MUC1
Zhao, Q., Duckworth, C. A., Wang, W. K., Guo, X., Barrow, H., Pritchard, D. M., . . . Yu, L. G. (2014). Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galactin-3 to promote metastasis by interaction with cancer-associated MUC1. Carcinogenesis, 35(12), 2815-2821. doi:10.1093/carcin/bgu216
Serial surveillance of carcinoid heart disease: factors associated with echocardiographic progression and mortality
Dobson, R., Burgess, M. I., Valle, J. W., Pritchard, D. M., Vora, J., Wong, C., . . . Cuthbertson, D. J. (2014). Serial surveillance of carcinoid heart disease: factors associated with echocardiographic progression and mortality. British Journal of Cancer, 111(09), 1703-1709. doi:10.1038/bjc.2014.468
Analysis of Clinical Isolates of Helicobacter pylori in Pakistan Reveals High Degrees of Pathogenicity and High Frequencies of Antibiotic Resistance
Rasheed, F., Campbell, B. J., Alfizah, H., Varro, A., Zahra, R., Yamaoka, Y., & Pritchard, D. M. (2014). Analysis of Clinical Isolates of Helicobacter pylori in Pakistan Reveals High Degrees of Pathogenicity and High Frequencies of Antibiotic Resistance. Helicobacter, 19(5), 387-399. doi:10.1111/hel.12142
The clinical presentation and management of carcinoid heart disease
Dobson, R., Burgess, M. I., Pritchard, D. M., & Cuthbertson, D. J. (2014). The clinical presentation and management of carcinoid heart disease. INTERNATIONAL JOURNAL OF CARDIOLOGY, 173(1), 29-32. doi:10.1016/j.ijcard.2014.02.037
Circulating galectins-2,-4 and-8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis
Chen, C., Duckworth, C. A., Fu, B., Pritchard, D. M., Rhodes, J. M., & Yu, L. -G. (2014). Circulating galectins-2,-4 and-8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis. BRITISH JOURNAL OF CANCER, 110(3), 741-752. doi:10.1038/bjc.2013.793
Circulating galectins -2, -4 and -8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis
Chen, C., Duckworth, C. A., Fu, B., Pritchard, D. M., Rhodes, J. M., & Yu, L. G. (2014). Circulating galectins -2, -4 and -8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis. Br J Cancer, 110(3), 741-752. doi:10.1038/bjc.2013.793
2013
Signaling mediated by the NF-κB sub-units NF-κB1, NF-κB2 and c-Rel differentially regulate <i>Helicobacter felis</i>-induced gastric carcinogenesis in C57BL/6 mice
Burkitt, M. D., Williams, J. M., Duckworth, C. A., O'Hara, A., Hanedi, A., Varro, A., . . . Pritchard, D. M. (2013). Signaling mediated by the NF-κB sub-units NF-κB1, NF-κB2 and c-Rel differentially regulate <i>Helicobacter felis</i>-induced gastric carcinogenesis in C57BL/6 mice. ONCOGENE, 32(50), 5563-5573. doi:10.1038/onc.2013.334
A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide
Williams, J. M., Duckworth, C. A., Watson, A. J. M., Frey, M. R., Miguel, J. C., Burkitt, M. D., . . . Pritchard, D. M. (2013). A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide. DISEASE MODELS & MECHANISMS, 6(6), 1388-1399. doi:10.1242/dmm.013284
Proteomic profiling of a mouse model of acute intestinal <i>Apc</i> deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC)
Hammoudi, A., Song, F., Reed, K. R., Jenkins, R. E., Meniel, V. S., Watson, A. J. M., . . . Jenkins, J. R. (2013). Proteomic profiling of a mouse model of acute intestinal <i>Apc</i> deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC). BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 440(3), 364-370. doi:10.1016/j.bbrc.2013.08.076
Effects of EGFR Inhibitor on Helicobacter pylori Induced Gastric Epithelial Pathology in Vivo.
Crabtree, J. E., Jeremy, A. H. T., Duval, C., Dixon, M. F., Danjo, K., Carr, I. M., . . . Robinson, P. A. (2013). Effects of EGFR Inhibitor on Helicobacter pylori Induced Gastric Epithelial Pathology in Vivo.. Pathogens (Basel, Switzerland), 2(4), 571-590. doi:10.3390/pathogens2040571
Netazepide, a Gastrin Receptor Antagonist, Normalises Tumour Biomarkers and Causes Regression of Type 1 Gastric Neuroendocrine Tumours in a Nonrandomised Trial of Patients with Chronic Atrophic Gastritis
Moore, A. R., Boyce, M., Steele, I. A., Campbell, F., Varro, A., & Pritchard, D. M. (2013). Netazepide, a Gastrin Receptor Antagonist, Normalises Tumour Biomarkers and Causes Regression of Type 1 Gastric Neuroendocrine Tumours in a Nonrandomised Trial of Patients with Chronic Atrophic Gastritis. PLOS ONE, 8(10). doi:10.1371/journal.pone.0076462
The Association of a Panel of Biomarkers with the Presence and Severity of Carcinoid Heart Disease: A Cross-Sectional Study
Dobson, R., Burgess, M. I., Banks, M., Pritchard, D. M., Vora, J., Valle, J. W., . . . Cuthbertson, D. J. (2013). The Association of a Panel of Biomarkers with the Presence and Severity of Carcinoid Heart Disease: A Cross-Sectional Study. PLOS ONE, 8(9). doi:10.1371/journal.pone.0073679
752 Deletion of Specific NFκB Proteins Regulates Susceptibility to Developing Colitis Associated Cancer in C57BL/6 Mice As a Result of Altered Inflammatory and DNA Damage Responses
Hanedi, A., Burkitt, M. D., Williams, J. M., Duckworth, C. A., Caamano, J., & Pritchard, D. M. (2013). 752 Deletion of Specific NFκB Proteins Regulates Susceptibility to Developing Colitis Associated Cancer in C57BL/6 Mice As a Result of Altered Inflammatory and DNA Damage Responses. Gastroenterology, 144(5), S-136. doi:10.1016/s0016-5085(13)60492-8
Mo1807 Lipopolysaccharide Induces Small Intestinal Epithelial Cell Apoptosis and Shedding by a TLR4 and TNFR1 Dependent Mechanism, Which Is Regulated by NFκB Signalling
Williams, J. M., Duckworth, C. A., Campbell, B. J., Frey, M. R., Miguel, J. C., Burkitt, M. D., . . . Pritchard, D. M. (2013). Mo1807 Lipopolysaccharide Induces Small Intestinal Epithelial Cell Apoptosis and Shedding by a TLR4 and TNFR1 Dependent Mechanism, Which Is Regulated by NFκB Signalling. Gastroenterology, 144(5), S-668. doi:10.1016/s0016-5085(13)62476-2
Sa2016 Netazepide, a Gastrin/CCK-2 Receptor Antagonist, Causes Regression of Type 1 Gastric Neuroendocrine Tumors and Reduces Expression of Chromogranin a and Histidine Decarboxylase Genes in Chronic Atrophic Gastritis
Moore, A. R., Boyce, M. J., Steele, I., Campbell, F., Varro, A., & Pritchard, D. M. (2013). Sa2016 Netazepide, a Gastrin/CCK-2 Receptor Antagonist, Causes Regression of Type 1 Gastric Neuroendocrine Tumors and Reduces Expression of Chromogranin a and Histidine Decarboxylase Genes in Chronic Atrophic Gastritis. Gastroenterology, 144(5), S-360. doi:10.1016/s0016-5085(13)61325-6
The role of plasminogen activator inhibitor-1 in gastric mucosal protection
Kenny, S., Steele, I., Lyons, S., Moore, A. R., Murugesan, S. V., Tiszlavicz, L., . . . Dockray, G. J. (2013). The role of plasminogen activator inhibitor-1 in gastric mucosal protection. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 304(9), G814-G822. doi:10.1152/ajpgi.00017.2013
Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation
Radulescu, S., Ridgway, R. A., Cordero, J., Athineos, D., Salgueiro, P., Poulsom, R., . . . Sansom, O. J. (2013). Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation. ONCOGENE, 32(16), 2048-2057. doi:10.1038/onc.2012.224
Peptide receptor radionuclide therapy with <SUP>90</SUP>Y-DOTATATE/<SUP>90</SUP>Y-DOTATOC in patients with progressive metastatic neuroendocrine tumours: assessment of response, survival and toxicity
Vinjamuri, S., Gilbert, T. M., Banks, M., McKane, G., Maltby, P., Poston, G., . . . Cuthbertson, D. J. (2013). Peptide receptor radionuclide therapy with <SUP>90</SUP>Y-DOTATATE/<SUP>90</SUP>Y-DOTATOC in patients with progressive metastatic neuroendocrine tumours: assessment of response, survival and toxicity. BRITISH JOURNAL OF CANCER, 108(7), 1440-1448. doi:10.1038/bjc.2013.103
Correlation between a short-term intravenous octreotide suppression test and response to antrectomy in patients with type-1 gastric neuroendocrine tumours
Murugesan, S. V., Steele, I. A., Dimaline, R., Poston, G. J., Shrotri, M., Campbell, F., . . . Pritchard, D. M. (2013). Correlation between a short-term intravenous octreotide suppression test and response to antrectomy in patients with type-1 gastric neuroendocrine tumours. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 25(4), 474-481. doi:10.1097/MEG.0b013e32835cec52
Increased Circulation of Galectin-3 in Cancer Induces Secretion of Metastasis-Promoting Cytokines from Blood Vascular Endothelium
Chen, C., Duckworth, C. A., Zhao, Q., Pritchard, D. M., Rhodes, J. M., & Yu, L. -G. (2013). Increased Circulation of Galectin-3 in Cancer Induces Secretion of Metastasis-Promoting Cytokines from Blood Vascular Endothelium. CLINICAL CANCER RESEARCH, 19(7), 1693-1704. doi:10.1158/1078-0432.CCR-12-2940
Near-field optical microscopy with an infra-red free electron laser applied to cancer diagnosis
Smith, A. D., Siggel-King, M. R. F., Holder, G. M., Cricenti, A., Luce, M., Harrison, P., . . . Weightman, P. (2013). Near-field optical microscopy with an infra-red free electron laser applied to cancer diagnosis. APPLIED PHYSICS LETTERS, 102(5). doi:10.1063/1.4790436
<i>CYP2C19*17</i> Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease
Musumba, C. O., Jorgensen, A., Sutton, L., Van Eker, D., Zhang, E., O'Hara, N., . . . Pirmohamed, M. (2013). <i>CYP2C19*17</i> Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease. CLINICAL PHARMACOLOGY & THERAPEUTICS, 93(2), 195-203. doi:10.1038/clpt.2012.215
Correction: Netazepide, a Gastrin Receptor Antagonist, Normalises Tumour Biomarkers and Causes Regression of Type 1 Gastric Neuroendocrine Tumours in a Nonrandomised Trial of Patients with Chronic Atrophic Gastritis
Correction: Netazepide, a Gastrin Receptor Antagonist, Normalises Tumour Biomarkers and Causes Regression of Type 1 Gastric Neuroendocrine Tumours in a Nonrandomised Trial of Patients with Chronic Atrophic Gastritis (2013). PloS one, 8(11).
Progastrin-Induced Secretion of Insulin-Like Growth Factor 2 From Colonic Myofibroblasts Stimulates Colonic Epithelial Proliferation in Mice
Duckworth, C. A., Clyde, D., Worthley, D. L., Wang, T. C., Varro, A., & Pritchard, D. M. (2013). Progastrin-Induced Secretion of Insulin-Like Growth Factor 2 From Colonic Myofibroblasts Stimulates Colonic Epithelial Proliferation in Mice. GASTROENTEROLOGY, 145(1), 197-+. doi:10.1053/j.gastro.2013.03.012
2012
Gastrin receptor pharmacology.
Dockray, G. J., Moore, A., Varro, A., & Pritchard, D. M. (2012). Gastrin receptor pharmacology.. Current gastroenterology reports, 14(6), 453-459. doi:10.1007/s11894-012-0293-1
Gastric <i>Helicobacter</i> Infection Induces Iron Deficiency in the INS-GAS Mouse
Thomson, M. J., Pritchard, D. M., Boxall, S. A., Abuderman, A. A., Williams, J. M., Varro, A., & Crabtree, J. E. (2012). Gastric <i>Helicobacter</i> Infection Induces Iron Deficiency in the INS-GAS Mouse. PLOS ONE, 7(11). doi:10.1371/journal.pone.0050194
CD24 is expressed in gastric parietal cells and regulates apoptosis and the response to <i>Helicobacter felis</i> infection in the murine stomach
Duckworth, C. A., Clyde, D., & Pritchard, D. M. (2012). CD24 is expressed in gastric parietal cells and regulates apoptosis and the response to <i>Helicobacter felis</i> infection in the murine stomach. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 303(8), G915-G926. doi:10.1152/ajpgi.00068.2012
Letter: are idiopathic (non-NSAID, non-Helicobacter pylori) ulcers really increasing? Authors' reply
Musumba, C., Hopkins, M., Pritchard, D. M., & Pirmohamed, M. (2012). Letter: are idiopathic (non-NSAID, non-Helicobacter pylori) ulcers really increasing? Authors' reply. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 36(6), 601-602. doi:10.1111/apt.12001
Commentary: changing aetiology of peptic ulcers - author's reply
Musumba, C., Pritchard, D. M., & Pirmohamed, M. (2012). Commentary: changing aetiology of peptic ulcers - author's reply. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 36(3), 292-293. doi:10.1111/j.1365-2036.2012.05176.x
Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease
Kiesslich, R., Duckworth, C. A., Moussata, D., Gloeckner, A., Lim, L. G., Goetz, M., . . . Watson, A. J. M. (2012). Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease. Gut, 61(8), 1146-1153. doi:10.1136/gutjnl-2011-300695
Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease
Kiesslich, R., Duckworth, C. A., Moussata, D., Gloeckner, A., Lim, L. G., Goetz, M., . . . Watson, A. J. M. (2012). Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease. GUT, 61(8), 1146-1153. doi:10.1136/gutjnl-2011-300695
CYP2C19*17 GAIN OF FUNCTION MUTATION IS ASSOCIATED WITH PEPTIC ULCER DISEASE
Musumba, C. O., Eker, D. V., Jorgensen, A., Pritchard, D. M., & Pirmohamed, M. (2012). CYP2C19*17 GAIN OF FUNCTION MUTATION IS ASSOCIATED WITH PEPTIC ULCER DISEASE. GUT, 61, A363. doi:10.1136/gutjnl-2012-302514d.165
Pro-GRP-Derived Peptides Are Expressed in Colorectal Cancer Cells and Tumors and Are Biologically Active <i>in Vivo</i>
Patel, O., Clyde, D., Chang, M., Nordlund, M. S., Steel, R., Kemp, B. E., . . . Baldwin, G. S. (2012). Pro-GRP-Derived Peptides Are Expressed in Colorectal Cancer Cells and Tumors and Are Biologically Active <i>in Vivo</i>. ENDOCRINOLOGY, 153(3), 1082-1092. doi:10.1210/en.2011-1875
Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity (vol 103, pg 19, 1998)
Pritchard, D. M., Jackman, A., Potten, C. S., & Hickman, J. A. (2012). Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity (vol 103, pg 19, 1998). TOXICOLOGY LETTERS, 208(1), 75. doi:10.1016/j.toxlet.2011.10.009
The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010
Musumba, C., Jorgensen, A., Sutton, L., Van Eker, D., Moorcroft, J., Hopkins, M., . . . Pirmohamed, M. (2012). The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 36(1), 48-56. doi:10.1111/j.1365-2036.2012.05118.x
2011
Gastrin stimulates expression of plasminogen activator inhibitor-1 in gastric epithelial cells
Norsett, K. G., Steele, I., Duval, C., Sammut, S. J., Murugesan, S. V. M., Kenny, S., . . . Varro, A. (2011). Gastrin stimulates expression of plasminogen activator inhibitor-1 in gastric epithelial cells. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 301(3), G446-G453. doi:10.1152/ajpgi.00527.2010
IFN-γ Inhibits Gastric Carcinogenesis by Inducing Epithelial Cell Autophagy and T-Cell Apoptosis
Tu, S. P., Quante, M., Bhagat, G., Takaishi, S., Cui, G., Yang, X. D., . . . Wang, T. C. (2011). IFN-γ Inhibits Gastric Carcinogenesis by Inducing Epithelial Cell Autophagy and T-Cell Apoptosis. CANCER RESEARCH, 71(12), 4247-4259. doi:10.1158/0008-5472.CAN-10-4009
Bak Deficiency Alters Gastric Epithelial Homeostasis and Modulates the Consequences of Helicobacter felis Infection In Vivo
Duckworth, C. A., Abuderman, A. A., Burkitt, M. D., & Pritchard, D. M. (2011). Bak Deficiency Alters Gastric Epithelial Homeostasis and Modulates the Consequences of Helicobacter felis Infection In Vivo. Gastroenterology, 140(5), S-824. doi:10.1016/s0016-5085(11)63414-8
CD24 Co-Localises With DCAMKL-1 in the Intestine and Regulates Epithelial Apoptosis and Crypt Regeneration Following Damage Inducing Stimuli
Duckworth, C. A., Clyde, D., & Pritchard, D. M. (2011). CD24 Co-Localises With DCAMKL-1 in the Intestine and Regulates Epithelial Apoptosis and Crypt Regeneration Following Damage Inducing Stimuli. Gastroenterology, 140(5), S-6. doi:10.1016/s0016-5085(11)60026-7
Classical and Alternative Pathway Nuclear Factor-κB Signalling Differentially Regulate Gastric Epithelial Responses to Helicobacter felis Infection
Burkitt, M. D., Varro, A., Caamano, J., & Pritchard, D. M. (2011). Classical and Alternative Pathway Nuclear Factor-κB Signalling Differentially Regulate Gastric Epithelial Responses to Helicobacter felis Infection. Gastroenterology, 140(5), S-673. doi:10.1016/s0016-5085(11)62791-1
Classical and Alternative Pathway Nuclear Factor-κB Signalling Regulate Gastric Epithelial Responses to γ-Irradiation
Burkitt, M. D., Duckworth, C. A., Varro, A., Caamano, J., & Pritchard, D. M. (2011). Classical and Alternative Pathway Nuclear Factor-κB Signalling Regulate Gastric Epithelial Responses to γ-Irradiation. Gastroenterology, 140(5), S-823. doi:10.1016/s0016-5085(11)63410-0
Determinants of Human Fasting Serum Gastrin Concentration- Interaction Between H. pylori Infection, Gastric Preneoplastic Pathology and Proton Pump Inhibitor Use
Murugesan, S. V., Steele, I., Tiszlavicz, L., Farragher, T., Moore, A. R., Pritchard, D. M., & Varro, A. (2011). Determinants of Human Fasting Serum Gastrin Concentration- Interaction Between H. pylori Infection, Gastric Preneoplastic Pathology and Proton Pump Inhibitor Use. Gastroenterology, 140(5), S-729. doi:10.1016/s0016-5085(11)63030-8
Factors That Determine the Sensitivity of Rapid Urease Tests for the Detection of Helicobacter pylori Infection
Murugesan, S. V., Steele, I., Tiszlavicz, L., Farragher, T., Moore, A. R., Varro, A., & Pritchard, D. M. (2011). Factors That Determine the Sensitivity of Rapid Urease Tests for the Detection of Helicobacter pylori Infection. Gastroenterology, 140(5), S-879. doi:10.1016/s0016-5085(11)63654-8
Progastrin Stimulates Colonic Myofibroblast Proliferation In Vitro and Its Transgenic Overexpression Increases Colonic Myofibroblast Abundance In Vivo
Clyde, D., Duckworth, C. A., Varro, A., Wang, T. C., & Pritchard, D. M. (2011). Progastrin Stimulates Colonic Myofibroblast Proliferation In Vitro and Its Transgenic Overexpression Increases Colonic Myofibroblast Abundance In Vivo. Gastroenterology, 140(5), S-106. doi:10.1016/s0016-5085(11)60429-0
The Effects of Host, Environmental and Bacterial Factors on Development of Gastric Preneoplastic Pathology
Murugesan, S. V., Tiszlavicz, L., Steele, I., Farragher, T., Moore, A. R., Varro, A., & Pritchard, D. M. (2011). The Effects of Host, Environmental and Bacterial Factors on Development of Gastric Preneoplastic Pathology. Gastroenterology, 140(5). doi:10.1016/s0016-5085(11)62805-9
Bak Deficiency Alters Gastric Epithelial Homeostasis and Modulates the Consequences of Helicobacter fells Infection <i>In Vivo</i>
Duckworth, C. A., Abuderman, A. A., Burkitt, M. D., & Pritchard, D. M. (2011). Bak Deficiency Alters Gastric Epithelial Homeostasis and Modulates the Consequences of Helicobacter fells Infection <i>In Vivo</i>. GASTROENTEROLOGY, 140(5), S824. Retrieved from https://www.webofscience.com/
Zollinger-Ellison Syndrome: Still a Diagnostic Challenge in the 21st Century?
Pritchard, D. M. (2011). Zollinger-Ellison Syndrome: Still a Diagnostic Challenge in the 21st Century?. GASTROENTEROLOGY, 140(5), 1380-1383. doi:10.1053/j.gastro.2011.03.026
2010
Gastrin regulates the urokinase plasminogen activator system
Norsett, K. G., Steele, I., Rainbow, L., Murugesam, S. V. M., Duval, C., Kenny, S., . . . Varro, A. (2010). Gastrin regulates the urokinase plasminogen activator system. REGULATORY PEPTIDES, 164(1), 29. doi:10.1016/j.regpep.2010.07.067
The management of gastric polyps
Goddard, A. F., Badreldin, R., Pritchard, D. M., Walker, M. M., & Warren, B. (2010). The management of gastric polyps. GUT, 59(9), 1270-1276. doi:10.1136/gut.2009.182089
587 EGFR Inhibitor Reduces Helicobacter-Induced Upregulation of Gastric Activation-Induced Cytidine Deaminase in the Murine INS-GAS Cancer Model
Duval, C., Pritchard, D. M., Abuderman, A., Varro, A., Robinson, P. A., & Crabtree, J. E. (2010). 587 EGFR Inhibitor Reduces Helicobacter-Induced Upregulation of Gastric Activation-Induced Cytidine Deaminase in the Murine INS-GAS Cancer Model. Gastroenterology, 138(5), S-84. doi:10.1016/s0016-5085(10)60382-4
S1693 Progrp-Derived Peptides are Present in Human Colorectal Cancer Cells and Stimulate Proliferation In Vitro and in the Murine Colonic Mucosa In Vivo
Patel, O., Clyde, D., Chang, M., Nordlund, M. S., Pritchard, D. M., Shulkes, A., & Baldwin, G. S. (2010). S1693 Progrp-Derived Peptides are Present in Human Colorectal Cancer Cells and Stimulate Proliferation In Vitro and in the Murine Colonic Mucosa In Vivo. Gastroenterology, 138(5), S-255. doi:10.1016/s0016-5085(10)61163-8
Conditional Deletion of IκB-Kinase-β Accelerates <i>Helicobacter</i>-Dependent Gastric Apoptosis, Proliferation, and Preneoplasia
Shibata, W., Takaishi, S., Muthupalani, S., Pritchard, D. M., Whary, M. T., Rogers, A. B., . . . Wang, T. C. (2010). Conditional Deletion of IκB-Kinase-β Accelerates <i>Helicobacter</i>-Dependent Gastric Apoptosis, Proliferation, and Preneoplasia. GASTROENTEROLOGY, 138(3), 1022-U295. doi:10.1053/j.gastro.2009.11.054
2009
Review article: cellular and molecular mechanisms of NSAID-induced peptic ulcers
Musumba, C., Pritchard, D. M., & Pirmohamed, M. (2009). Review article: cellular and molecular mechanisms of NSAID-induced peptic ulcers. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 30(6), 517-531. doi:10.1111/j.1365-2036.2009.04086.x
Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice
Jin, G., Ramanathan, V., Quante, M., Baik, G. H., Yang, X., Wang, S. S. W., . . . Wang, T. C. (2009). Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice. JOURNAL OF CLINICAL INVESTIGATION, 119(9), 2691-2701. doi:10.1172/JCI38918
Review article: strategies to determine whether hypergastrinaemia is due to Zollinger-Ellison syndrome rather than a more common benign cause
Murugesan, S. V. M., Varro, A., & Pritchard, D. M. (2009). Review article: strategies to determine whether hypergastrinaemia is due to Zollinger-Ellison syndrome rather than a more common benign cause. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 29(10), 1055-1068. doi:10.1111/j.1365-2036.2009.03976.x
T1633 Gastric Helicobacter Infection Induces Iron Deficiency in the INS-GAS Mouse
Boxall, S., Pritchard, D. M., Abuderman, A., Wang, T. C., Varro, A., & Crabtree, J. E. (2009). T1633 Gastric Helicobacter Infection Induces Iron Deficiency in the INS-GAS Mouse. Gastroenterology, 136(5), A-547. doi:10.1016/s0016-5085(09)62513-0
KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract
Zheng, H., Pritchard, D. M., Yang, X., Bennett, E., Liu, G., Liu, C., & Ai, W. (2009). KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 296(3), G490-G498. doi:10.1152/ajpgi.90393.2008
Importance of gastrin in the pathogenesis and treatment of gastric tumors
Burkitt, M. D., Varro, A., & Pritchard, D. M. (2009). Importance of gastrin in the pathogenesis and treatment of gastric tumors. WORLD JOURNAL OF GASTROENTEROLOGY, 15(1), 1-16. doi:10.3748/wjg.15.1
Suppression of Apoptosis, Crypt Hyperplasia, and Altered Differentiation in the Colonic Epithelia of <i>Bak</i>-Null Mice
Duckworth, C. A., & Pritchard, D. M. (2009). Suppression of Apoptosis, Crypt Hyperplasia, and Altered Differentiation in the Colonic Epithelia of <i>Bak</i>-Null Mice. GASTROENTEROLOGY, 136(3), 943-952. doi:10.1053/j.gastro.2008.11.036
2008
Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor
Pritchard, D. M., Berry, D., Przemeck, S. M. C., Campbell, F., Edwards, S. W., & Varro, A. (2008). Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 295(4), G798-G805. doi:10.1152/ajpgi.00015.2008
Increased expression of the urokinase plasminogen activator system by <i>Helicobacter pylori</i> in gastric epithelial cells
Kenny, S., Duval, C., Sammut, S. J., Steele, I., Pritchard, D. M., Atherton, J. C., . . . Varro, A. (2008). Increased expression of the urokinase plasminogen activator system by <i>Helicobacter pylori</i> in gastric epithelial cells. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 295(3), G431-G441. doi:10.1152/ajpgi.90283.2008
606 KLF4 Is a Downstream Target of the Notch Signaling Pathway That Controls Goblet Cell Differentiation in the Mouse GI Tract
Yang, X., Pritchard, D. M., Takaishi, S., Tu, S., Marrache, F., Gordon, S. A., . . . Ai, W. (2008). 606 KLF4 Is a Downstream Target of the Notch Signaling Pathway That Controls Goblet Cell Differentiation in the Mouse GI Tract. Gastroenterology, 134(4), A-84. doi:10.1016/s0016-5085(08)60396-0
812 Inactivation of Cholecystokinin-2 Receptor Inhibits Progastrin-Dependent Colonic Proliferation and Colorectal Cancer in Mice
Jin, G., Dubeykovskiy, A. N., Pritchard, D. M., Betz, K. S., Varro, A., & Wang, T. C. (2008). 812 Inactivation of Cholecystokinin-2 Receptor Inhibits Progastrin-Dependent Colonic Proliferation and Colorectal Cancer in Mice. Gastroenterology, 134(4), A-115. doi:10.1016/s0016-5085(08)60537-5
Assessment of the efficacy and toxicity of <SUP>131</SUP>I-metaiodobenzylguanidine therapy for metastatic neuroendocrine tumours
Nwosu, A. C., Jones, L., Vora, J., Poston, G. J., Vinjamuri, S., & Pritchard, D. M. (2008). Assessment of the efficacy and toxicity of <SUP>131</SUP>I-metaiodobenzylguanidine therapy for metastatic neuroendocrine tumours. BRITISH JOURNAL OF CANCER, 98(6), 1053-1058. doi:10.1038/sj.bjc.6604273
Hypergastrinemia increases gastric epithelial susceptibility to apoptosis
Przemeck, S. M. C., Varro, A., Berry, D., Steele, I., Wang, T. C., Dockray, G. J., & Pritchard, D. M. (2008). Hypergastrinemia increases gastric epithelial susceptibility to apoptosis. Regulatory Peptides, 146(1-3), 147-156. doi:10.1016/j.regpep.2007.09.002
Hypergastrinemia increases gastric epithelial susceptibility to apoptosis
Przemeck, S. M. C., Varro, A., Berry, D., Steele, I., Wang, T. C., Dockray, G. J., & Pritchard, D. M. (2008). Hypergastrinemia increases gastric epithelial susceptibility to apoptosis. REGULATORY PEPTIDES, 146(1-3), 147-156. doi:10.1016/j.regpep.2007.09.002
Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine <i>Helicobacter</i> infection
Bodger, K., Ahmed, S., Pazmany, L., Pritchard, D. M., Micheal, A., Khan, A. L., . . . Varro, A. (2008). Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine <i>Helicobacter</i> infection. JOURNAL OF CLINICAL PATHOLOGY, 61(1), 72-78. doi:10.1136/jcp.2007.048058
Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine<i>Helicobacter</i>infection
Bodger, K., Ahmed, S., Pazmany, L., Pritchard, D. M., Micheal, A., Khan, A. L., . . . Varro, A. (2008). Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine<i>Helicobacter</i>infection. Journal of Clinical Pathology, 61(1), 72-78. doi:10.1136/jcp.2007.048058
2007
<i>Helicobacter</i> and gastrin stimulate Reg1 expression in gastric epithelial cells through distinct promoter elements
Steele, I. A., Dimaline, R., Pritchard, D. M., Peek, R. M. J., Wang, T. C., Dockray, G. J., & Varro, A. (2007). <i>Helicobacter</i> and gastrin stimulate Reg1 expression in gastric epithelial cells through distinct promoter elements. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 293(1), G347-G354. doi:10.1152/ajpgi.00076.2007
Pathogenesis of gastrinomas associated with multiple endocrine neoplasia type 1
Pritchard, D. M. (2007). Pathogenesis of gastrinomas associated with multiple endocrine neoplasia type 1. GUT, 56(5), 606-607. doi:10.1136/gut.2006.113985
Increased gastric expression of MMP-7 in hypergastrinemia and significance for epithelial-mesenchymal signaling
Varro, A., Kenny, S., Hemers, E., McCaig, C., Przemeck, S., Wang, T. C., . . . Pritchard, D. M. (2007). Increased gastric expression of MMP-7 in hypergastrinemia and significance for epithelial-mesenchymal signaling. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 292(4), G1133-G1140. doi:10.1152/ajpgi.00526.2006
Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2
Przemeck, S. M. C., Duckworth, C. A., & Pritchard, D. M. (2007). Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 292(2), G620-G627. doi:10.1152/ajpgi.00391.2006
Bak-null mice demonstrate suppression of epithelial apoptosis, crypt hyperplasia and altered differentiation in the colon, and are more susceptible to colonic carcinogenesis
Duckworth, C. A., & Pritchard, D. M. (2007). Bak-null mice demonstrate suppression of epithelial apoptosis, crypt hyperplasia and altered differentiation in the colon, and are more susceptible to colonic carcinogenesis. GASTROENTEROLOGY, 132(4), A154. Retrieved from https://www.webofscience.com/
2006
<i>Helicobacter pylori</i> and gastric cancer
Pritchard, D. M., & Crabtree, J. E. (2006). <i>Helicobacter pylori</i> and gastric cancer. CURRENT OPINION IN GASTROENTEROLOGY, 22(6), 620-625. doi:10.1097/01.mog.0000245539.50765.f6
Review article: pathogenesis and management of gastric carcinoid tumours
Burkitt, M. D., & Pritchard, D. M. (2006). Review article: pathogenesis and management of gastric carcinoid tumours. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 24(9), 1305-1320. doi:10.1111/j.1365-2036.2006.03130.x
Characterization of epithelial cell shedding from human small intestine
Bullen, T. F., Forrest, S., Campbell, F., Dodson, A. R., Hershman, M. J., Pritchard, D. M., . . . Watson, A. J. M. (2006). Characterization of epithelial cell shedding from human small intestine. LABORATORY INVESTIGATION, 86(10), 1052-1063. doi:10.1038/labinvest.3700464
Gastrin-induced apoptosis contributes to carcinogenesis in the stomach
Cui, G., Takaishi, S., Ai, W., Betz, K. S., Florholmen, J., Koh, T. J., . . . Wang, T. C. (2006). Gastrin-induced apoptosis contributes to carcinogenesis in the stomach. LABORATORY INVESTIGATION, 86(10), 1037-1051. doi:10.1038/labinvest.3700462
Gastrin and members of the bcl-2 family regulate gastric epithelial apoptosis in vivo
Przemeck, S., Duckworth, C. A., Varro, A., Pritchard, D., & Pritchard, M. (2006). Gastrin and members of the bcl-2 family regulate gastric epithelial apoptosis in vivo. GUT, 55, A61. Retrieved from https://www.webofscience.com/
Gastrin increases MCL-1 expression in AGS<sub>GR</sub> gastric epithelial cells to cause supression of apoptosis
Przemeck, S., Varro, A., & Pritchard, D. M. (2006). Gastrin increases MCL-1 expression in AGS<sub>GR</sub> gastric epithelial cells to cause supression of apoptosis. In GUT Vol. 55 (pp. A27). Retrieved from https://www.webofscience.com/
Gastrin increases murine intestinal crypt regeneration following injury
Ottewell, P. D., Duckworth, C. A., Varro, A., Dimaline, R., Wang, T. C., Watson, A. J. M., . . . Pritchard, D. M. (2006). Gastrin increases murine intestinal crypt regeneration following injury. GASTROENTEROLOGY, 130(4), 1169-1180. doi:10.1053/j.gastro.2005.12.033
Suppression of colonic epithelial apoptosis and crypt hyperplasia occurs in <i>bak</i>-null mice
Duckworth, C. A., & Pritchard, D. M. (2006). Suppression of colonic epithelial apoptosis and crypt hyperplasia occurs in <i>bak</i>-null mice. GUT, 55, A9. Retrieved from https://www.webofscience.com/
The role of matrix metalloprotease-7 in redefining the gastric micro-environment in response to gastrin and <i>H pylori</i>
Varro, A., Pritchard, D. M., McCaig, C., Duval, C., Campbell, F., Ahmed, S., . . . Kerrigan, D. D. (2006). The role of matrix metalloprotease-7 in redefining the gastric micro-environment in response to gastrin and <i>H pylori</i>. In GUT Vol. 55 (pp. A114). Retrieved from https://www.webofscience.com/
The role of matrix metalloproteinase-7 in redefining the gastric microenvironment in response to <i>Helicobacter pylori</i>
McCaig, C., Duval, C., Hemers, E., Steele, I., Pritchard, D. M., Przemeck, S., . . . Varro, A. (2006). The role of matrix metalloproteinase-7 in redefining the gastric microenvironment in response to <i>Helicobacter pylori</i>. GASTROENTEROLOGY, 130(6), 1754-1763. doi:10.1053/j.gastro.2006.02.031
2005
Models of gastric cancer
Pritchard, D. M. (2005). Models of gastric cancer. Drug Discovery Today: Disease Models, 2(1), 21-26. doi:10.1016/j.ddmod.2005.05.001
COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivo
Ottewell, P. D., Varro, A., Dockray, G. J., Kirton, C. M., Watson, A. J. M., Wang, T. C., . . . Pritchard, D. M. (2005). COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivo. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 288(3), G541-G549. doi:10.1152/ajpgi.00268.2004
Gastrin induces MDM-2 and suppresses p53 expression in AGS<sub>GR</sub> cells, resulting in resistance to DNA damage induced apoptosis
Przemeck, S. M. C., Watson, A. J., Varro, A., & Pritchard, D. M. (2005). Gastrin induces MDM-2 and suppresses p53 expression in AGS<sub>GR</sub> cells, resulting in resistance to DNA damage induced apoptosis. GUT, 54, A87-A88. Retrieved from https://www.webofscience.com/
Gastrin induces mdm-2 and suppresses p53 protein expression in Ags-GR cells, resulting in resistance to DNA damage induced apoptosis
Przemeck, S. M., Watson, A. J., Varro, A., & Pritichard, D. M. (2005). Gastrin induces mdm-2 and suppresses p53 protein expression in Ags-GR cells, resulting in resistance to DNA damage induced apoptosis. Gastroenterology, 128(4 Supp), A-141.
Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced intestinal mucositis in mice.
Duckworth, C. A., Ottewell, P. D., Varro, A., Dimaline, R., & Pritchard, D. M. (2005). Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced intestinal mucositis in mice.. GASTROENTEROLOGY, 128(4), A203. Retrieved from https://www.webofscience.com/
Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced mucositis in mice
Duckworth, C. A., Ottewell, P. D., Dimaline, R., Varro, A., & Pritchard, D. M. (2005). Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced mucositis in mice. GUT, 54, A98. Retrieved from https://www.webofscience.com/
Radiation induces gastrin-CCK<sub>B</sub> receptor expression in IEC-6 and IEC-18 intestinal epithelial cells
Ottewell, P. D., Watson, A. J., Varro, A., & Pritchard, D. M. (2005). Radiation induces gastrin-CCK<sub>B</sub> receptor expression in IEC-6 and IEC-18 intestinal epithelial cells. GUT, 54, A88. Retrieved from https://www.webofscience.com/
Radiation induces p53 dependent apoptosis in the proliferative zone of mouse gastric epithelium
Przemeck, S. M. C., Ottewell, P. D., Watson, A. J. M., & Pritchard, D. M. (2005). Radiation induces p53 dependent apoptosis in the proliferative zone of mouse gastric epithelium. GUT, 54, A88. Retrieved from https://www.webofscience.com/
Shedding of human intestinal epithelial cells results in gaps in the epithelial monolayer
Bullen, T. F., Campbell, F., Pritchard, D. M., Hershman, M. J., & Watson, A. J. M. (2005). Shedding of human intestinal epithelial cells results in gaps in the epithelial monolayer. GUT, 54, A25. Retrieved from https://www.webofscience.com/
Th1 cytokines, but not gastrin increase <i>Helicobacter pylori</i> induced apoptosis in short term primary cultures of murine gastric glands
Przemeck, M. C., Watson, A. J., Varro, A., & Pritchard, D. M. (2005). Th1 cytokines, but not gastrin increase <i>Helicobacter pylori</i> induced apoptosis in short term primary cultures of murine gastric glands. GUT, 54, A61. Retrieved from https://www.webofscience.com/
2004
Review article: how useful are the rodent animal models of gastric adenocarcinoma?
Pritchard, D. M., & Przemeck, S. M. C. (2004). Review article: how useful are the rodent animal models of gastric adenocarcinoma?. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 19(8), 841-859. doi:10.1111/j.1365-2036.2004.01911.x
<i>Helicobacter pylori</i> induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-κB and RhoA:: Implications for invasion and apoptosis
Varro, A., Noble, P. J. M., Pritchard, D. M., Kennedy, S., Hart, C. A., Dimaline, R., & Dockray, G. J. (2004). <i>Helicobacter pylori</i> induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-κB and RhoA:: Implications for invasion and apoptosis. CANCER RESEARCH, 64(5), 1695-1702. doi:10.1158/0008-5472.CAN-03-2399
Helicobacter pylori induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-kappaB and RhoA: implications for invasion and apoptosis
Varro, A., Noble, P. J., Pritchard, D. M., Kennedy, S., Hart, C. A., Dimaline, R., & Dockray, G. J. (2004). Helicobacter pylori induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-kappaB and RhoA: implications for invasion and apoptosis. Cancer Res, 64(5), 1695-1702. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/14996729
Helicobacter pylori induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-kappaB and RhoA: implications for invasion and apoptosis
Varro, A., Noble, P. J., Pritchard, D. M., Kennedy, S., Hart, C. A., Dimaline, R., & Dockray, G. J. (2004). Helicobacter pylori induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-kappaB and RhoA: implications for invasion and apoptosis. Cancer Res, 64(5), 1695-1702. Retrieved from http://www.ncbi.nlm.nih.gov/
MMP-7 acts as a signal from epithelial cells to myofibroblasts in gastric carcinoid tumours
Varro, A., Hemers, E., & Pritchard, D. M. (2004). MMP-7 acts as a signal from epithelial cells to myofibroblasts in gastric carcinoid tumours. In BRITISH JOURNAL OF CANCER Vol. 91 (pp. S10). Retrieved from https://www.webofscience.com/
New role for gastrin in regulating epithelial-mesenchymal signalling via MMP-7 in gastric carcinoid tumours
Hemers, E., Pritchard, D. M., Campbell, F., Ahmed, S., Bodger, K., Kerrigan, D. D., . . . Varro, A. (2004). New role for gastrin in regulating epithelial-mesenchymal signalling via MMP-7 in gastric carcinoid tumours. In REGULATORY PEPTIDES Vol. 122 (pp. 45). Retrieved from https://www.webofscience.com/
Regulation of plasminogen activator inhibitor 2 (PAI-2) by <i>Helicobacter pylori</i>:: Role in invasion and in apoptosis
Varro, A., Noble, P. J. M., Pritchard, D. M., Kennedy, S., Dimaline, R., Hart, C. A., & Dockray, G. J. (2004). Regulation of plasminogen activator inhibitor 2 (PAI-2) by <i>Helicobacter pylori</i>:: Role in invasion and in apoptosis. In GUT Vol. 53 (pp. A15). Retrieved from https://www.webofscience.com/
2003
Can proton pump inhibitors be blamed for the rising incidence of esophageal cancer?
Younes, M. (2003). Can proton pump inhibitors be blamed for the rising incidence of esophageal cancer?. GASTROENTEROLOGY, 125(6), 1912. doi:10.1053/j.gastro.2003.04.014
Gastrin-induced hyperproliferation in Barrett's esophagus - Reply
Haigh, C. R., Kirton, C. M., Pritchard, D. M., Varro, A., Dimaline, R., Attwood, S. E. A., . . . Jankowski, J. A. (2003). Gastrin-induced hyperproliferation in Barrett's esophagus - Reply. GASTROENTEROLOGY, 125(6), 1921-1922. doi:10.1053/j.gastro.2003.10.036
Stimulation of matrix metalloproteinase-7 (MMP-7) by Helicobacter pylori in gastric epithelial cells: role in epithelial cell migration
Wroblewski, L. E., Noble, P. -J., Pagliocca, A., Pritchard, D. M., Hart, C. T., & Varro, A. (2003). Stimulation of matrix metalloproteinase-7 (MMP-7) by Helicobacter pylori in gastric epithelial cells: role in epithelial cell migration. Gastroenterology, 124(4), A6. doi:10.1016/s0016-5085(03)80030-6
Gastrin induces proliferation in Barrett's metaplasia through activation of the CCK<sub>2</sub> receptor
Haigh, C. R., Attwood, S. E. A., Thompson, D. G., Jankowski, J. A., Kirton, C. M., Pritchard, D. M., . . . Dimaline, R. (2003). Gastrin induces proliferation in Barrett's metaplasia through activation of the CCK<sub>2</sub> receptor. GASTROENTEROLOGY, 124(3), 615-625. doi:10.1053/gast.2003.50091
Can proton pump inhibitors be blamed for the rising incidence of esophageal cancer? Reply
Haigh, C. R., Kirton, C., Pritchard, D. M., Varro, A., Dimaline, R., Attwood, S. E. A., . . . Jankowski, J. A. (2003). Can proton pump inhibitors be blamed for the rising incidence of esophageal cancer? Reply. GASTROENTEROLOGY, 125(6), 1912-1913. doi:10.1053/j.gastro.2003.10.031
Elevated plasma concentrations of amidated gastrin cause increased crypt survival in murine intestinal epithelia after γ radiation
Ottewell, P. D., Watson, A. J. M., Wang, T. C., Varro, A., Dockray, G. J., & Pritchard, D. M. (2003). Elevated plasma concentrations of amidated gastrin cause increased crypt survival in murine intestinal epithelia after γ radiation. GUT, 52, A8. Retrieved from https://www.webofscience.com/
Gastrin-induced hyperproliferation in Barrett's esophagus
Fitzgerald, R. C., & Abdalla, S. (2003). Gastrin-induced hyperproliferation in Barrett's esophagus. GASTROENTEROLOGY, 125(6), 1921. doi:10.1053/j.gastro.2003.05.017
Progastrin stimulates murine colonic epithelial mitosis after DNA damage.
Ottewell, P. D., Watson, A. J., Wang, T. C., Varro, A., Dockray, G. J., & Pritchard, D. M. (2003). Progastrin stimulates murine colonic epithelial mitosis after DNA damage.. Gastroenterology, 124(5), 1348-1357. doi:10.1016/S0016-5085(03)00288-9
Stimulation of matrix metalloproteinase-7 (MMP-7) by <i>Helicobacter pylori</i> in gastric epithelial cells:: Role in epithelial cell migration
Varro, A., Wroblewski, L. E., Pagliocca, A., Pritchard, D. M., Noble, P. J. M., & Hart, C. A. (2003). Stimulation of matrix metalloproteinase-7 (MMP-7) by <i>Helicobacter pylori</i> in gastric epithelial cells:: Role in epithelial cell migration. In GUT Vol. 52 (pp. A53). Retrieved from https://www.webofscience.com/
2002
Gastrin-stimulated gastric epithelial cell invasion: the role and mechanism of increased matrix metalloproteinase 9 expression
Wroblewski, L. E., Pritchard, D. M., Carter, S., & Varro, A. (2002). Gastrin-stimulated gastric epithelial cell invasion: the role and mechanism of increased matrix metalloproteinase 9 expression. BIOCHEMICAL JOURNAL, 365, 873-879. doi:10.1042/BJ20020068
Progastrin Stimulates Murine Colonic Epithelial Mitosis after Dna Damage
Pritchard, D. M., Ottewell, P. D., Watson, A. J. M., Wang, T. C., & Dockray, G. J. (2002). Progastrin Stimulates Murine Colonic Epithelial Mitosis after Dna Damage. Clinical Science, 103(s47), 43P. doi:10.1042/cs103043p
Amidated gastrin induces proliferation via the cholecystokinin type 2 (CCK<sub>2</sub>) receptor in Barrett's oesophagus
Haigh, C. R., Attwood, S. E. A., Thompson, D. G., Kirton, C. M., Pritchard, D. M., Varro, A., & Dimaline, R. (2002). Amidated gastrin induces proliferation via the cholecystokinin type 2 (CCK<sub>2</sub>) receptor in Barrett's oesophagus. In JOURNAL OF PHYSIOLOGY-LONDON Vol. 543 (pp. 50P). Retrieved from https://www.webofscience.com/
Progastrin stimulates murine colonic epithelial mitosis after DNA damage
Ottewell, P. D., Watson, A. J. M., Wang, T. C., Dockray, G. J., & Pritchard, D. M. (2002). Progastrin stimulates murine colonic epithelial mitosis after DNA damage. GUT, 50, A93. Retrieved from https://www.webofscience.com/
2000
Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine
Pritchard, D. M., Print, C., O'Reilly, L., Adams, J. M., Potten, C. S., & Hickman, J. A. (2000). Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine. ONCOGENE, 19(34), 3955-3959. doi:10.1038/sj.onc.1203729
BCL-W expression is an important determinant of damage-induced apoptosis in murine small and large intestinal epithelium in vivo
Pritchard, D. M., Print, C., Adams, J. M., Potten, C. S., & Hickman, J. A. (2000). BCL-W expression is an important determinant of damage-induced apoptosis in murine small and large intestinal epithelium in vivo. Gastroenterology, 118(4), A538. doi:10.1016/s0016-5085(00)84284-5
New directions in the treatment of colorectal cancer: a look to the future
Sobrero, A., Kerr, D., Glimelius, B., Van Cutsem, E., Milano, G., Pritchard, D. M., . . . Aapro, M. (2000). New directions in the treatment of colorectal cancer: a look to the future. EUROPEAN JOURNAL OF CANCER, 36(5), 559-566. doi:10.1016/S0959-8049(99)00314-7
Balb/c mice as a preclinical model for raltitrexed-induced gastrointestinal toxicity
Clarke, S. J., Farrugia, D. C., Aherne, G. W., Pritchard, D. M., Benstead, J., & Jackman, A. L. (2000). Balb/c mice as a preclinical model for raltitrexed-induced gastrointestinal toxicity. CLINICAL CANCER RESEARCH, 6(1), 285-296. Retrieved from https://www.webofscience.com/
Lessons from genetically engineered animal models VII. Apoptosis in intestinal epithelium: Lessons from transgenic and knockout mice
Watson, A. J. M., & Pritchard, D. M. (2000). Lessons from genetically engineered animal models VII. Apoptosis in intestinal epithelium: Lessons from transgenic and knockout mice. American Journal of Physiology - Gastrointestinal and Liver Physiology, 278(1 41-1). doi:10.1152/ajpgi.2000.278.1.g1
Lessons from genetically engineered animal models VII. Apoptosis in intestinal epithelium: lessons from transgenic and knockout mice
Watson, A. J. M., & Pritchard, D. M. (2000). Lessons from genetically engineered animal models VII. Apoptosis in intestinal epithelium: lessons from transgenic and knockout mice. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 278(1), G1-G5. doi:10.1152/ajpgi.2000.278.1.G1
The importance of p53-independent apoptosis in the intestinal toxicity induced by raltitrexed (ZD1694, Tomudex): Genetic differences between BALB/c and DBA/2 mice
Pritchard, D. M., Bower, L., Potten, C. S., Jackman, A. L., & Hickman, J. A. (2000). The importance of p53-independent apoptosis in the intestinal toxicity induced by raltitrexed (ZD1694, Tomudex): Genetic differences between BALB/c and DBA/2 mice. CLINICAL CANCER RESEARCH, 6(11), 4389-4395. Retrieved from https://www.webofscience.com/
1999
Damage-induced apoptosis in intestinal epithelia from <i>bcl</i>-2-null and <i>bax</i>-null mice:: investigations of the mechanistic determinants of epithelial apoptosis <i>in vivo</i>
Pritchard, D. M., Potten, C. S., Korsmeyer, S. J., Roberts, S., & Hickman, J. A. (1999). Damage-induced apoptosis in intestinal epithelia from <i>bcl</i>-2-null and <i>bax</i>-null mice:: investigations of the mechanistic determinants of epithelial apoptosis <i>in vivo</i>. ONCOGENE, 18(51), 7287-7293. doi:10.1038/sj.onc.1203150
Role of Bcl-2 Family Members in Homeostasis, in Toxicology in Normal Intestine, and for Prognosis of Colonic Carcinomas
Pritchard, D. M. (1999). Role of Bcl-2 Family Members in Homeostasis, in Toxicology in Normal Intestine, and for Prognosis of Colonic Carcinomas. In Apoptosis and Cancer Chemotherapy (pp. 275-290). Humana Press. doi:10.1007/978-1-59259-720-8_18
1998
Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity
Pritchard, D. M., Jackman, A., Potten, C. S., & Hickman, J. A. (1998). Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity. TOXICOLOGY LETTERS, 103, 19-27. doi:10.1016/S0378-4274(98)00273-2
The relationships between p53-dependent apoptosis, inhibition of proliferation, and 5-fluorouracil-induced histopathology in murine intestinal epithelia
Pritchard, D. M., Potten, C. S., & Hickman, J. A. (1998). The relationships between p53-dependent apoptosis, inhibition of proliferation, and 5-fluorouracil-induced histopathology in murine intestinal epithelia. CANCER RESEARCH, 58(23), 5453-5465. Retrieved from https://www.webofscience.com/
Radiation-induced p53 and p21<SUP>WAF-1/CIP1</SUP> expression in the murine intestinal epithelium -: Apoptosis and cell cycle arrest
Wilson, J. W., Pritchard, D. M., Hickman, J. A., & Potten, C. S. (1998). Radiation-induced p53 and p21<SUP>WAF-1/CIP1</SUP> expression in the murine intestinal epithelium -: Apoptosis and cell cycle arrest. AMERICAN JOURNAL OF PATHOLOGY, 153(3), 899-909. doi:10.1016/S0002-9440(10)65631-3
1997
The intestinal epithelial stem cell: the mucosal governor
Potten, C. S., Booth, C., & Pritchard, D. M. (1997). The intestinal epithelial stem cell: the mucosal governor. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 78(4), 219-243. doi:10.1046/j.1365-2613.1997.280362.x
Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: Evidence for the involvement of RNA perturbation
Pritchard, D. M., Watson, A. J. M., Potten, C. S., Jackman, A. L., & Hickman, J. A. (1997). Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: Evidence for the involvement of RNA perturbation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 94(5), 1795-1799. doi:10.1073/pnas.94.5.1795
1996
Apoptosis and gastrointestinal pharmacology
Pritchard, D. M., & Watson, A. J. M. (1996). Apoptosis and gastrointestinal pharmacology. PHARMACOLOGY & THERAPEUTICS, 72(2), 149-169. doi:10.1016/S0163-7258(96)00102-7