Research
My research group explores the structure and function bacterial proteins, primarily associated with bacterial virulence. We draw on techniques from structural biology (mainly X-crystallography), biochemistry and microbiology to understand the underpinning mechanisms of virulence. Our group works collaboratively across disciplines, integrating expertise in infection biology, medicinal chemistry and multi-omics techniques.
Our attention is currently focussed on Acinetobacter baumannii, which is the leading cause of nosocomial infections worldwide, where its high resistance to antibiotic treatments and ability to cause lethal infections, has led to its categorisation as a “critical priority” pathogen by the WHO. In light of this, novel therapeutic strategies are urgently needed to address this problematic pathogen. Our group is interested in targeting bacterial virulence factors; specifically reducing pathogen fitness and its ability to cause disease, without exerting a high selection pressure for resistance or affecting commensal bacteria. However, a key limitation in using this approach against A. baumannii, is the current lack of understanding concerning the molecular mechanisms underpinning virulence. Hence, we are interested in characterising virulence factors and their molecular mechanisms, with the aim of developing inhibitors. We are currently pursuing metal acquisition and utilisation machinery, biofilm assembly and secreted lytic enzymes as targets of our investigations.
We welcome enquiries from enthusiastic individuals, who are interested in PhD study. To discuss projects please contact Dr Harding. Please see (here) for a current, funded PhD opportunity.