Publications
Selected publications
- An anti-biofilm cyclic peptide targets a secreted aminopeptidase from P. aeruginosa. (Journal article - 2023)
- A rotary mechanism for allostery in bacterial hybrid malic enzymes. (Journal article - 2021)
- A lysozyme with altered substrate specificity facilitates prey cell exit by the periplasmic predator Bdellovibrio bacteriovorus. (Journal article - 2020)
2024
Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament
Snapshots of the Reaction Coordinate of a Thermophilic 2'-Deoxyribonucleoside/ribonucleoside Transferase.
Tang, P., Harding, C. J., Dickson, A. L., da Silva, R. G., Harrison, D. J., & Czekster, C. M. (2024). Snapshots of the Reaction Coordinate of a Thermophilic 2'-Deoxyribonucleoside/ribonucleoside Transferase.. ACS catalysis, 14(5), 3090-3102. doi:10.1021/acscatal.3c06260
2023
Unveiling the Catalytic Mechanism of a Processive Metalloaminopeptidase.
Simpson, M. C., Harding, C. J., Czekster, R. M., Remmel, L., Bode, B. E., & Czekster, C. M. (2023). Unveiling the Catalytic Mechanism of a Processive Metalloaminopeptidase.. Biochemistry, 62(22), 3188-3205. doi:10.1021/acs.biochem.3c00420
An anti-biofilm cyclic peptide targets a secreted aminopeptidase from P. aeruginosa.
Harding, C. J., Bischoff, M., Bergkessel, M., & Czekster, C. M. (2023). An anti-biofilm cyclic peptide targets a secreted aminopeptidase from P. aeruginosa.. Nature chemical biology, 19(9), 1158-1166. doi:10.1038/s41589-023-01373-8
2022
Active site remodelling of a cyclodipeptide synthase redefines substrate scope.
Sutherland, E., Harding, C. J., & Czekster, C. M. (2022). Active site remodelling of a cyclodipeptide synthase redefines substrate scope.. Communications chemistry, 5, 101. doi:10.1038/s42004-022-00715-2
2021
A rotary mechanism for allostery in bacterial hybrid malic enzymes.
Harding, C. J., Cadby, I. T., Moynihan, P. J., & Lovering, A. L. (2021). A rotary mechanism for allostery in bacterial hybrid malic enzymes.. Nature communications, 12(1), 1228. doi:10.1038/s41467-021-21528-2
Bypassing the requirement for aminoacyl-tRNA by a cyclodipeptide synthase enzyme.
Harding, C. J., Sutherland, E., Hanna, J. G., Houston, D. R., & Czekster, C. M. (2021). Bypassing the requirement for aminoacyl-tRNA by a cyclodipeptide synthase enzyme.. RSC chemical biology, 2(1), 230-240. doi:10.1039/d0cb00142b
2020
A lysozyme with altered substrate specificity facilitates prey cell exit by the periplasmic predator Bdellovibrio bacteriovorus.
Harding, C. J., Huwiler, S. G., Somers, H., Lambert, C., Ray, L. J., Till, R., . . . Lovering, A. L. (2020). A lysozyme with altered substrate specificity facilitates prey cell exit by the periplasmic predator Bdellovibrio bacteriovorus.. Nature communications, 11(1), 4817. doi:10.1038/s41467-020-18139-8
2019
Target highlights in CASP13: Experimental target structures through the eyes of their authors.
Lepore, R., Kryshtafovych, A., Alahuhta, M., Veraszto, H. A., Bomble, Y. J., Bufton, J. C., . . . Schwede, T. (2019). Target highlights in CASP13: Experimental target structures through the eyes of their authors.. Proteins, 87(12), 1037-1057. doi:10.1002/prot.25805
Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport system.
Hughes, G. W., Hall, S. C. L., Laxton, C. S., Sridhar, P., Mahadi, A. H., Hatton, C., . . . Knowles, T. J. (2019). Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport system.. Nature microbiology, 4(10), 1692-1705. doi:10.1038/s41564-019-0481-y