Publications
2024
Blood cell defence against pathogens
Abrams, S. T., & Toh, C. -H. (2024). Blood cell defence against pathogens. The Lancet Haematology, 11(10), e728. doi:10.1016/s2352-3026(24)00286-2
Revisiting the full blood count: Circulating blood cells and their role in coagulation.
Schofield, J., Yong, J., & Toh, C. -H. (2024). Revisiting the full blood count: Circulating blood cells and their role in coagulation.. British journal of haematology. doi:10.1111/bjh.19690
P.028: Optimisation of donation after circulatory death livers – removal of extracellular histones during normothermic perfusion and following whole blood reperfusion in an ex-situ porcine model.
Hussain Abbas, S., Dengu, F., Schofield, J., Wang, G., Morovat, A., Quaglia, A., . . . Friend, P. (2024). P.028: Optimisation of donation after circulatory death livers – removal of extracellular histones during normothermic perfusion and following whole blood reperfusion in an ex-situ porcine model.. Transplantation, 108(9S). doi:10.1097/01.tp.0001067024.19971.ae
The Highs and Lows of ADAMTS13 Activity.
Shaw, R. J., Abrams, S. T., Badu, S., Toh, C. -H., & Dutt, T. (2024). The Highs and Lows of ADAMTS13 Activity.. Journal of clinical medicine, 13(17), 5152. doi:10.3390/jcm13175152
Fibrinogen binding to histones in circulation protects against adverse cellular and clinical outcomes.
Toh, J. M., Yong, J., Abrams, S. T., Wang, L., Schofield, J., Lane, S., . . . Toh, C. -H. (2024). Fibrinogen binding to histones in circulation protects against adverse cellular and clinical outcomes.. Journal of thrombosis and haemostasis : JTH, 22(8), 2247-2260. doi:10.1016/j.jtha.2024.05.009
The convergent model of coagulation.
Yong, J., & Toh, C. -H. (2024). The convergent model of coagulation.. Journal of thrombosis and haemostasis : JTH, 22(8), 2140-2146. doi:10.1016/j.jtha.2024.05.014
Restoring discarded porcine lungs by ex vivo removal of neutrophil extracellular traps.
Mittendorfer, M., Pierre, L., Huzevka, T., Schofield, J., Abrams, S. T., Wang, G., . . . Lindstedt, S. (2024). Restoring discarded porcine lungs by ex vivo removal of neutrophil extracellular traps.. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, S1053-2498(24)01736-4. doi:10.1016/j.healun.2024.07.007
The Highs and Lows of ADAMTS13 Activity
Wider use of tranexamic acid to reduce surgical bleeding could benefit patients and health systems.
Roberts, I., Murphy, M. F., Moonesinghe, R., Grocott, M. P. W., Kalumbi, C., Sayers, R., . . . UK Royal Colleges Tranexamic Acid in Surgery Implementation Group. (2024). Wider use of tranexamic acid to reduce surgical bleeding could benefit patients and health systems.. BMJ (Clinical research ed.), 385, e079444. doi:10.1136/bmj-2024-079444
Identification of cross reactive T cell responses in adenovirus based COVID 19 vaccines.
Gardner, J., Abrams, S. T., Toh, C. -H., Parker, A. L., Lovatt, C., Nicolson, P. L. R., . . . Naisbitt, D. J. (2024). Identification of cross reactive T cell responses in adenovirus based COVID 19 vaccines.. NPJ vaccines, 9(1), 99. doi:10.1038/s41541-024-00895-z
Infected Blood Inquiry details failure after failure.
Toh, C. -H., & Buggins, E. (2024). Infected Blood Inquiry details failure after failure.. BMJ (Clinical research ed.), 385, q1220. doi:10.1136/bmj.q1220
Are NETs a Novel, Exciting, Thrombosis Risk Marker?
Wang, G., Abrams, S. T., & Toh, C. -H. (2024). Are NETs a Novel, Exciting, Thrombosis Risk Marker?. Thrombosis and haemostasis, 124(5), 455-458. doi:10.1055/a-2187-0645
Alternative routes into clinical research: a guide for early career doctors.
Nicolson, P. L., Belete, M., Hawes, R., Fowler, N., & Toh, C. H. (2024). Alternative routes into clinical research: a guide for early career doctors.. BMJ (Clinical research ed.), 385, e076414. doi:10.1136/bmj-2023-076414
How to approach acute thrombosis and thrombocytopenia
Schofield, J., & Toh, C. -H. (2024). How to approach acute thrombosis and thrombocytopenia. CLINICAL MEDICINE, 23(3), 234-241. doi:10.7861/clinmed2023-0076
Amyloid-Fibrinogen Aggregates ("Microclots") Predict Risks of Disseminated Intravascular Coagulation and Mortality.
Schofield, J., Abrams, S. T., Jenkins, R., Lane, S., Wang, G., & Toh, C. -H. (2024). Amyloid-Fibrinogen Aggregates ("Microclots") Predict Risks of Disseminated Intravascular Coagulation and Mortality.. Blood advances, bloodadvances.2023012473. doi:10.1182/bloodadvances.2023012473
Shades of Grey-The brain in TTP.
Dutt, T., & Toh, C. -H. (2024). Shades of Grey-The brain in TTP.. British journal of haematology, 204(3), 757-758. doi:10.1111/bjh.19293
Trauma-induced innate immune activation and disseminated intravascular coagulation.
Gando, S., Levi, M., & Toh, C. -H. (2024). Trauma-induced innate immune activation and disseminated intravascular coagulation.. Journal of thrombosis and haemostasis : JTH, 22(2), 337-351. doi:10.1016/j.jtha.2023.09.028
2023
Rethinking coagulation: from enzymatic cascade and cell-based reactions to a convergent model involving innate immune activation.
Yong, J., & Toh, C. -H. (2023). Rethinking coagulation: from enzymatic cascade and cell-based reactions to a convergent model involving innate immune activation.. Blood, 142(25), 2133-2145. doi:10.1182/blood.2023021166
Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia.
Abrams, S. T., Du, M., Shaw, R. J., Johnson, C., McGuinness, D., Schofield, J., . . . Toh, C. -H. (2023). Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia.. Journal of thrombosis and haemostasis : JTH, S1538-7836(23)00873-5. doi:10.1016/j.jtha.2023.12.008
How can we ensure that the right patient gets the right blood at the right time?
Toh, C. -H. (2023). How can we ensure that the right patient gets the right blood at the right time?. BMJ (Clinical research ed.), 383, 2446. doi:10.1136/bmj.p2446
OC 78.5 Systemic Snakebite Envenoming Causes Histone-Induced Thrombocytopaenia
Schofield, J., Abrams, S., Alhamdi, Y., Ainsworth, S., Evans, C., Albulescu, L., . . . Toh, C. (2023). OC 78.5 Systemic Snakebite Envenoming Causes Histone-Induced Thrombocytopaenia. Research and Practice in Thrombosis and Haemostasis, 7, 100487. doi:10.1016/j.rpth.2023.100487
PB0794 Fibrinogen Protects against Histone-Induced Thrombocytopaenia
Yong, J., Abrams, S., Alhamdi, Y., Wang, G., & Toh, C. (2023). PB0794 Fibrinogen Protects against Histone-Induced Thrombocytopaenia. Research and Practice in Thrombosis and Haemostasis, 7, 101370. doi:10.1016/j.rpth.2023.101370
Delivering trials in the NHS: more than worth it.
Haynes, R., Mafham, M., Toh, C. H., & Landray, M. J. (2023). Delivering trials in the NHS: more than worth it.. Clinical medicine (London, England), 23(5), 525-526. doi:10.7861/clinmed.2023-0296
How to approach acute thrombosis and thrombocytopenia.
Schofield, J., & Toh, C. -H. (2023). How to approach acute thrombosis and thrombocytopenia.. Clinical medicine (London, England), 23(3), 234-241. doi:10.7861/clinmed2023-0076
Cell-free histones and the cell-based model of coagulation.
Yong, J., Abrams, S. T., Wang, G., & Toh, C. -H. (2023). Cell-free histones and the cell-based model of coagulation.. Journal of thrombosis and haemostasis : JTH, S1538-7836(23)00340-9. doi:10.1016/j.jtha.2023.04.018
Neutrophil Extracellular Traps Removal During Ex Vivo Lung Perfusion Improves Lung Function in Aspiration Damaged Porcine Lungs
Mittendorfer, M., Pierre, L., Kjellberg, G., Schofield, J., Abrams, S., Wang, G., . . . Lindstedt, S. (2023). Neutrophil Extracellular Traps Removal During Ex Vivo Lung Perfusion Improves Lung Function in Aspiration Damaged Porcine Lungs. In JOURNAL OF HEART AND LUNG TRANSPLANTATION Vol. 42 (pp. S115). Retrieved from https://www.webofscience.com/
A "Bundle of Care" to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study
Jorgensen, A. L., Orrell, C., Waitt, C., Toh, C. -H., Sekaggya-Wiltshire, C., Hughes, D. A., . . . Pirmohamed, M. (2023). A "Bundle of Care" to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study. JMIR RESEARCH PROTOCOLS, 12. doi:10.2196/46710
A “Bundle of Care” to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study (Preprint)
Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis
Abrams, S. T. T., Alhamdi, Y., Zi, M., Guo, F., Du, M., Wang, G., . . . Toh, C. -H. (2023). Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(4). doi:10.3390/ijms24043225
36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE.
Turpie, A. G. G., Farjat, A. E., Haas, S., Ageno, W., Weitz, J. I., Goldhaber, S. Z., . . . GARFIELD-VTE investigators. (2023). 36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE.. Thrombosis research, 222, 31-39. doi:10.1016/j.thromres.2022.11.016
Alan Randolph Giles, MD (1940-2022): dogged pioneer and esteemed hematologist
Senis, Y. A., Toh, C. -H., & Lillicrap, D. (2023). Alan Randolph Giles, MD (1940-2022): dogged pioneer and esteemed hematologist. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 21(2), 397-399. doi:10.1016/j.jtha.2022.10.026
Tranexamic acid for safer surgery: does the evidence support preventative use? Response to <i>Br J Anaesth</i> 2023; 130: e23-e24
Grocott, M. P. W., Murphy, M., Roberts, I., Sayers, R., & Toh, C. -H. (2023). Tranexamic acid for safer surgery: does the evidence support preventative use? Response to <i>Br J Anaesth</i> 2023; 130: e23-e24. BRITISH JOURNAL OF ANAESTHESIA, 130(2), E195-E196. doi:10.1016/j.bja.2022.11.010
2022
The Importance of Pore-Forming Toxins in Multiple Organ Injury and Dysfunction
Abrams, S. T. T., Wang, L., Yong, J., Yu, Q., Du, M., Alhamdi, Y., . . . Wang, G. (2022). The Importance of Pore-Forming Toxins in Multiple Organ Injury and Dysfunction. BIOMEDICINES, 10(12). doi:10.3390/biomedicines10123256
Tranexamic acid for safer surgery: the time is now
Grocott, M. P. W., Murphy, M., Roberts, I., Sayers, R., & Toh, C. -H. (2022). Tranexamic acid for safer surgery: the time is now. BRITISH JOURNAL OF ANAESTHESIA, 129(4), 459-461. doi:10.1016/j.bja.2022.06.024
Tranexamic acid for safer surgery: the time is now
Grocott, M. P. W., Murphy, M., Roberts, I., Sayers, R., & Toh, C. -H. (2022). Tranexamic acid for safer surgery: the time is now. BRITISH JOURNAL OF SURGERY, 109(12), 1182-1183. doi:10.1093/bjs/znac252
HaemSTAR-Growing Experience From a National, Trainee-led Research Network
Wilson, L., Doyle, A. J., Millen, E., Bull, T., Biss, T., Hart, D., . . . Nicolson, P. L. R. (2022). HaemSTAR-Growing Experience From a National, Trainee-led Research Network. HEMASPHERE, 6(9). doi:10.1097/HS9.0000000000000766
GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements.
Dixon, P. H., Levine, A. P., Cebola, I., Chan, M. M. Y., Amin, A. S., Aich, A., . . . Williamson, C. (2022). GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements.. Nature communications, 13(1), 4840. doi:10.1038/s41467-022-29931-z
The Health and Care Act 2022: challenges and priorities for embedding research in the NHS
Toh, C. H., & Haynes, R. (2022). The Health and Care Act 2022: challenges and priorities for embedding research in the NHS. LANCET, 400(10349), 343-345. doi:10.1016/S0140-6736(22)01195-3
The aetiopathogenesis of vaccine-induced immune thrombotic thrombocytopenia
Toh, C. -H., Wang, G., & Parker, A. L. (2022). The aetiopathogenesis of vaccine-induced immune thrombotic thrombocytopenia. CLINICAL MEDICINE, 22(2), 140-144. doi:10.7861/clinmed.2022-0006
Rare missense variants in Tropomyosin-4 (TPM4) are associated with platelet dysfunction, cytoskeletal defects, and excessive bleeding.
Stapley, R. J., Poulter, N. S., Khan, A. O., Smith, C. W., Bignell, P., Fratter, C., . . . UK GAPP Study Group. (2022). Rare missense variants in Tropomyosin-4 (TPM4) are associated with platelet dysfunction, cytoskeletal defects, and excessive bleeding.. Journal of thrombosis and haemostasis : JTH, 20(2), 478-485. doi:10.1111/jth.15584
Reduction of NETosis by targeting CXCR1/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsis
Alsabani, M., Abrams, S. T., Cheng, Z., Morton, B., Lane, S., Alosaimi, S., . . . Toh, C. -H. (2022). Reduction of NETosis by targeting CXCR1/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsis. British Journal of Anaesthesia, 128(2), 283-293. doi:10.1016/j.bja.2021.10.039
A single 1 g/kg dose of intravenous immunoglobulin is a safe and effective treatment for immune thrombocytopenia; results of the first HaemSTAR 'Flash-Mob' retrospective study incorporating 961 patients
Nicolson, P. L. R., Perry, R., Buka, R. J., Fisher, A., Scott, G., Magill, L., . . . Hill, Q. A. (2022). A single 1 g/kg dose of intravenous immunoglobulin is a safe and effective treatment for immune thrombocytopenia; results of the first HaemSTAR 'Flash-Mob' retrospective study incorporating 961 patients. BRITISH JOURNAL OF HAEMATOLOGY, 196(2), 433-437. doi:10.1111/bjh.17692
2021
Transfusion 2024: A 5-year plan for clinical and laboratory transfusion in England
Allard, S., Cort, J., Howell, C., Sherliker, L., Miflin, G., & Toh, C. H. (2021). Transfusion 2024: A 5-year plan for clinical and laboratory transfusion in England. TRANSFUSION MEDICINE, 31(6), 400-408. doi:10.1111/tme.12827
The art and science of the thrombosis with thrombocytopenia syndrome
Toh, C. -H. (2021). The art and science of the thrombosis with thrombocytopenia syndrome. CLINICAL MEDICINE, 21(6), E603. doi:10.7861/clinmed.2021-0525
Circulating histones play a central role in COVID-19-associated coagulopathy and mortality
Shaw, R. J., Abrams, S. T., Austin, J., Taylor, J. M., Lane, S., Dutt, T., . . . Toh, C. -H. (2021). Circulating histones play a central role in COVID-19-associated coagulopathy and mortality. HAEMATOLOGICA, 106(9), 2493-2498. doi:10.3324/haematol.2021.278492
COVID-19 and immunothrombosis: emerging understanding and clinical management
Shaw, R. J., Bradbury, C., Abrams, S. T., Wang, G., & Toh, C. -H. (2021). COVID-19 and immunothrombosis: emerging understanding and clinical management. BRITISH JOURNAL OF HAEMATOLOGY, 194(3), 518-529. doi:10.1111/bjh.17664
Intracranial hemorrhage in immune thrombotic thrombocytopenic purpura treated with caplacizumab
Schofield, J., Shaw, R. J., Lester, W., Thomas, W., Toh, C. -H., & Dutt, T. (2021). Intracranial hemorrhage in immune thrombotic thrombocytopenic purpura treated with caplacizumab. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 19(8), 1922-1925. doi:10.1111/jth.15363
Research 2021: never the same again.
Toh, C. -H., & Stewart, P. (2021). Research 2021: never the same again.. Future healthcare journal, 8(2), e187. doi:10.7861/fhj.ed.8.2.2
Real-world experience with caplacizumab in the management of acute TTP
Dutt, T., Shaw, R. J., Stubbs, M., Yong, J., Bailiff, B., Cranfield, T., . . . Scully, M. (2021). Real-world experience with caplacizumab in the management of acute TTP. BLOOD, 137(13), 1731-1740. doi:10.1182/blood.2020007599
Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation
Abrams, S. T., Su, D., Sahraoui, Y., Lin, Z., Cheng, Z., Nesbitt, K., . . . Toh, C. -H. (2021). Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation. BLOOD, 137(1), 103-114. doi:10.1182/blood.2019002973
ADAMTS13 activity trends in TTP patients with COVID-19 infection
Shaw, R. J., Kenworthy, J., Lawrenson, A., Toh, C. -H., & Dutt, T. (2021). ADAMTS13 activity trends in TTP patients with COVID-19 infection. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 193 (pp. 211). Retrieved from https://www.webofscience.com/
OPTIMISATION OF ORAL ANTICOAGULATION FOR STROKE PREVENTION: A SCOPING REVIEW OF FACTORS INFLUENCING UPTAKE AND IMPLEMENTATION IN EFFECTIVENESS STUDIES
Gibson, J., Weldon, J., Banerjee, A., Chauhan, U., Georgiou, R., Joshi, M., . . . Watkins, C. (2021). OPTIMISATION OF ORAL ANTICOAGULATION FOR STROKE PREVENTION: A SCOPING REVIEW OF FACTORS INFLUENCING UPTAKE AND IMPLEMENTATION IN EFFECTIVENESS STUDIES. In INTERNATIONAL JOURNAL OF STROKE Vol. 16 (pp. 37). Retrieved from https://www.webofscience.com/
2020
Extracellular histones stimulate collagen expression <i>in vitro</i> and promote liver fibrogenesis in a mouse model <i>via </i>the TLR4-MyD88 signaling pathway
Wang, Z., Cheng, Z. -X., Abrams, S. T., Lin, Z. -Q., Yates, E. D., Yu, Q., . . . Wang, G. -Z. (2020). Extracellular histones stimulate collagen expression <i>in vitro</i> and promote liver fibrogenesis in a mouse model <i>via </i>the TLR4-MyD88 signaling pathway. WORLD JOURNAL OF GASTROENTEROLOGY, 26(47), 7513-7527. doi:10.3748/wjg.v26.i47.7513
Circulating Histone Levels Correlate with the Severity of COVID-19 and the Extent of Coagulation Activation and Inflammation
Shaw, R. J., Austin, J., Taylor, J., Dutt, T., Wang, G., Abrams, S. T., & Toh, C. H. (2020). Circulating Histone Levels Correlate with the Severity of COVID-19 and the Extent of Coagulation Activation and Inflammation. In BLOOD Vol. 136. doi:10.1182/blood-2020-142344
Extracellular histones stimulate collagen expression and potentially promote liver fibrogenesis via TLR4-MyD88 signalling pathway
The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development
Cheng, Z., Abrams, S. T., Austin, J., Toh, J., Wang, S. S., Wang, Z., . . . Wang, G. (2020). The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development. MEDIATORS OF INFLAMMATION, 2020. doi:10.1155/2020/7418342
The Critical Roles and Mechanisms of Immune Cell Death in Sepsis
Cheng, Z., Abrams, S. T., Toh, J., Wang, S. S., Wang, Z., Yu, Q., . . . Wang, G. (2020). The Critical Roles and Mechanisms of Immune Cell Death in Sepsis. FRONTIERS IN IMMUNOLOGY, 11. doi:10.3389/fimmu.2020.01918
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort.
Thaventhiran, J. E. D., Lango Allen, H., Burren, O. S., Rae, W., Greene, D., Staples, E., . . . Smith, K. G. C. (2020). Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort.. Nature, 584(7819), E2. doi:10.1038/s41586-020-2556-6
Cancer associated thrombosis in everyday practice: perspectives from GARFIELD-VTE.
Weitz, J. I., Haas, S., Ageno, W., Goldhaber, S. Z., Turpie, A. G. G., Goto, S., . . . GARFIELD-VTE investigators. (2020). Cancer associated thrombosis in everyday practice: perspectives from GARFIELD-VTE.. Journal of thrombosis and thrombolysis, 50(2), 267-277. doi:10.1007/s11239-020-02180-x
Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria
Moxon, C. A., Alhamdi, Y., Storm, J., Toh, J. M. H., McGuinness, D., Ko, J. Y., . . . Toh, C. (n.d.). Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria. Blood Advances, 4(13), 2851-2864. doi:10.1182/bloodadvances.2019001258
Whole-genome sequencing of a sporadic primary immunodeficiency cohort
Thaventhiran, J. E. D., Allen, H. L., Burren, O. S., Rae, W., Greene, D., Staples, E., . . . Smith, K. G. C. (2020). Whole-genome sequencing of a sporadic primary immunodeficiency cohort. NATURE, 583(7814), 90-+. doi:10.1038/s41586-020-2265-1
Whole-genome sequencing of patients with rare diseases in a national health system
Turro, E., Astle, W. J., Megy, K., Graef, S., Greene, D., Shamardina, O., . . . Ouwehand, W. H. (2020). Whole-genome sequencing of patients with rare diseases in a national health system. NATURE, 583(7814), 96-+. doi:10.1038/s41586-020-2434-2
Complexes between C-Reactive Protein and Very Low Density Lipoprotein Delay Bacterial Clearance in Sepsis
Cheng, Z., Abrams, S. T., Toh, J., Wang, S. S., Downey, C., Ge, X., . . . Toh, C. -H. (2020). Complexes between C-Reactive Protein and Very Low Density Lipoprotein Delay Bacterial Clearance in Sepsis. Journal of Immunology, 204(10), 2712-2721. doi:10.4049/jimmunol.1900962
Parasite histones mediate blood-brain barrier disruption in cerebral malaria.
Moxon, C., Alhamdi, Y., Storm, J., Toh, J., Ko, J. Y., Murphy, G., . . . Toh, C. -H. (2020). Parasite histones mediate blood-brain barrier disruption in cerebral malaria.. Clinical medicine (London, England), 20(Suppl 2), s96-s97. doi:10.7861/clinmed.20-2-s96
Blood works
Toh, C. -H., & Amberley, K. (2020). Blood works. BRITISH JOURNAL OF HAEMATOLOGY, 189(3), 391-392. doi:10.1111/bjh.16650
A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit.
Abrams, S., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2020). A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit.. Clinical medicine (London, England), 20(Suppl 2), s114-s115. doi:10.7861/clinmed.20-2-s114
A cross-sectional evaluation of five warfarin anticoagulation services in Uganda and South Africa
Semakula, J. R., Mouton, J. P., Jorgensen, A., Hutchinson, C., Allie, S., Semakula, L., . . . Cohen, K. (2020). A cross-sectional evaluation of five warfarin anticoagulation services in Uganda and South Africa. PLOS ONE, 15(1). doi:10.1371/journal.pone.0227458
A novel assay of neutrophil extracellular traps (NETs) formation independently predicts DIC and identifies the rationale for anti-IL-8 therapies
Abrams, S., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2020). A novel assay of neutrophil extracellular traps (NETs) formation independently predicts DIC and identifies the rationale for anti-IL-8 therapies. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 189 (pp. 42). Retrieved from https://www.webofscience.com/
Patients with acute thrombotic thrombocytopenic purpura (TTP) should be managed in a critical care setting - A Single TTP Referral Centre Experience
Shaw, R. J., Garth, L., Toh, C. -H., & Dutt, T. (2020). Patients with acute thrombotic thrombocytopenic purpura (TTP) should be managed in a critical care setting - A Single TTP Referral Centre Experience. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 189 (pp. 268). Retrieved from https://www.webofscience.com/
2019
Enabling an equitable spread of research access, involvement, and funding in the UK
Toh, C. -H. (2019). Enabling an equitable spread of research access, involvement, and funding in the UK. LANCET, 394(10214), 2048-2050. Retrieved from https://www.webofscience.com/
A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies
Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2019). A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies. In BLOOD Vol. 134. Retrieved from https://www.webofscience.com/
A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies
Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2019). A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies. In BLOOD Vol. 134. doi:10.1182/blood-2019-128493
A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients
Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M., Lane, S., Welters, I. D., . . . Toh, C. -H. (2019). A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients. American journal of respiratory and critical care medicine, 200(07), 869-880. doi:10.1164/rccm.201811-2111oc
The European Hematology Exam: The Next Step toward the Harmonization of Hematology Training in Europe
Navarro, J. -T., Birgegard, G., Strivens, J., Hollegien, W. W. G., van Hattem, N., Saris, M. T., . . . Almeida, A. M. (2019). The European Hematology Exam: The Next Step toward the Harmonization of Hematology Training in Europe. HEMASPHERE, 3(5). doi:10.1097/HS9.0000000000000291
Circulating Histones Are Major Mediators of Multiple Organ Dysfunction Syndrome in Acute Critical Illnesses.
Cheng, Z., Abrams, S. T., Alhamdi, Y., Toh, J., Yu, W., Wang, G., & Toh, C. -H. (2019). Circulating Histones Are Major Mediators of Multiple Organ Dysfunction Syndrome in Acute Critical Illnesses.. Critical care medicine, 47(8), e677-e684. doi:10.1097/ccm.0000000000003839
Disseminated intravascular coagulation - what can we do?
Toh, C. -H., Toh, J. M. H., & Abrams, S. T. (2019). Disseminated intravascular coagulation - what can we do?. HEMASPHERE, 3, 92-94. doi:10.1097/HS9.0000000000000232
Germline selection shapes human mitochondrial DNA diversity
Wei, W., Tuna, S., Keogh, M. J., Smith, K. R., Aitman, T. J., Beales, P. L., . . . Chinnery, P. F. (2019). Germline selection shapes human mitochondrial DNA diversity. SCIENCE, 364(6442), 749-+. doi:10.1126/science.aau6520
Sepsis-associated coagulopathy and the association of platelet count with mortality
Welters, I. D. M., Waite, A., Alhamdi, Y., Abrams, S., Toh, C., Iqbal, R., & Venugopal, N. (2019). Sepsis-associated coagulopathy and the association of platelet count with mortality. In Critical Care Vol. 23, Suppl 2 (pp. 146). Brussels: Springer Nature.
Developing today's trainees to become tomorrow's clinical researchers - an innovative collaboration driving improvements in clinical training and research delivery.
Loizou, E., Karpha, I., Toh, C. -H., & Dutt, T. (2019). Developing today's trainees to become tomorrow's clinical researchers - an innovative collaboration driving improvements in clinical training and research delivery.. Future healthcare journal, 6(Suppl 1), 112. doi:10.7861/futurehosp.6-1-s112
Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis
Rhodes, C. J., Batai, K., Bleda, M., Haimel, M., Southgate, L., Germain, M., . . . Winslow, C. (2019). Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis. LANCET RESPIRATORY MEDICINE, 7(3), 227-238. doi:10.1016/S2213-2600(18)30409-0
Parasite histones mediate leak and coagulopathy in cerebral malaria
Characteristics and Management of Patients with Venous Thromboembolism: The GARFIELD-VTE Registry
Ageno, W., Haas, S., Weitz, J. I., Goldhaber, S. Z., Turpie, A. G. G., Goto, S., . . . Yang, Z. (2019). Characteristics and Management of Patients with Venous Thromboembolism: The GARFIELD-VTE Registry. THROMBOSIS AND HAEMOSTASIS, 119(2), 319-327. doi:10.1055/s-0038-1676611
A HaemSTAR is born; a trainee-led, UK-wide research network in haematology
Nicolson, P. L. R., Desborough, M. J. R., Hart, D., Biss, T. T., Lowe, G. C., & Toh, C. -H. (2019). A HaemSTAR is born; a trainee-led, UK-wide research network in haematology. CLINICAL MEDICINE, 19(6), 532-533. doi:10.7861/clinmed.2019-0313
DIAPH1-related disorder: audiological phenotype and comparison to MYH9-related disorder and Takenouchi-Kosaki syndrome
Westbury, S., Burney, C., Obaji, S., Collins, P., Toh, C. -H., & Mumford, A. (2019). DIAPH1-related disorder: audiological phenotype and comparison to MYH9-related disorder and Takenouchi-Kosaki syndrome. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 185 (pp. 134-135). Retrieved from https://www.webofscience.com/
Parasite histones are associated with poor outcome in cerebral malaria
Moxon, C., Alhamdi, Y., Storm, J., Toh, J., Ko, J. Y., Murphy, G., . . . Toh, C. -H. (2019). Parasite histones are associated with poor outcome in cerebral malaria. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 185 (pp. 33). Retrieved from https://www.webofscience.com/
2018
The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms
Ainsworth, S., Slagboom, J., Alomran, N., Pla, D., Alhamdi, Y., King, S. I., . . . Casewell, N. R. (2018). The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms. COMMUNICATIONS BIOLOGY, 1. doi:10.1038/s42003-018-0039-1
Histones Bind Prothrombin to Generate Alternative Prothrombinase Complexes That Can Disseminate Intravascular Coagulation
Abrams, S. T., Su, D., Sahraoui, Y., Alhamdi, Y., Wang, G., & Toh, C. H. (2018). Histones Bind Prothrombin to Generate Alternative Prothrombinase Complexes That Can Disseminate Intravascular Coagulation. In BLOOD Vol. 132. doi:10.1182/blood-2018-99-116117
Phenotype description and response to thrombopoietin receptor agonist in <i>DIAPH1</i>-related disorder
Westbury, S. K., Downes, K., Burney, C., Lozano, M. L., Obaji, S. G., Toh, C. H., . . . Mumford, A. D. (2018). Phenotype description and response to thrombopoietin receptor agonist in <i>DIAPH1</i>-related disorder. BLOOD ADVANCES, 2(18), 2341-2346. doi:10.1182/bloodadvances.2018020370
Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data (vol 8, 1300, 2018)
Farmery, J. H. R., Smith, M. L., Lynch, A. G., Huissoon, A., Furnell, A., Mead, A., . . . Tan, Y. (2018). Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data (vol 8, 1300, 2018). SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-018-31524-0
<i>De Novo</i> Truncating Mutations in <i>WASF1</i> Cause Intellectual Disability with Seizures
Ito, Y., Carss, K. J., Duarte, S. T., Hartley, T., Keren, B., Kurian, M. A., . . . Raymond, F. L. (2018). <i>De Novo</i> Truncating Mutations in <i>WASF1</i> Cause Intellectual Disability with Seizures. AMERICAN JOURNAL OF HUMAN GENETICS, 103(1), 144-153. doi:10.1016/j.ajhg.2018.06.001
A re-evaluation of the D-dimer cut-off value for making a diagnosis according to the ISTH overt-DIC diagnostic criteria: communication from the SSC of the ISTH
Suzuki, K., Wada, H., Imai, H., Iba, T., Thachil, J., & Toh, C. -H. (2018). A re-evaluation of the D-dimer cut-off value for making a diagnosis according to the ISTH overt-DIC diagnostic criteria: communication from the SSC of the ISTH. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 16(7), 1442-1444. doi:10.1111/jth.14134
Extracellular Histones Inhibit Complement Activation through Interacting with Complement Component 4
Qaddoori, Y., Abrams, S. T., Mould, P., Alhamdi, Y., Christmas, S. E., Wang, G., & Toh, C. -H. (2018). Extracellular Histones Inhibit Complement Activation through Interacting with Complement Component 4. JOURNAL OF IMMUNOLOGY, 200(12), 4125-4133. doi:10.4049/jimmunol.1700779
The European Hematology Curriculum: An Electronic Passport Promoting Professional Competence and Mobility
Almeida, A. M., Ar, C., Hellstrom-Lindberg, E., Hollegien, W. W. G., Navarro, J. T., Saris, M. T., . . . Toh, C. H. (2018). The European Hematology Curriculum: An Electronic Passport Promoting Professional Competence and Mobility. HEMASPHERE, 2(3). doi:10.1097/HS9.0000000000000049
Circulating histones are major mediators of cardiac complications in sepsis
Wang, G., Alhamdi, Y., Abrams, S. T., & Toh, C. H. (2018). Circulating histones are major mediators of cardiac complications in sepsis. In CARDIOVASCULAR RESEARCH Vol. 114 (pp. S99). doi:10.1093/cvr/cvy060.294
Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data
Farmery, J. H. R., Smith, M. L., & Lynch, A. G. (2018). Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data. SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-017-14403-y
Case report: A successful pregnancy in Haemophillia A
Yong, J., & Toh, C. -H. (2018). Case report: A successful pregnancy in Haemophillia A. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 181 (pp. 205). Retrieved from https://www.webofscience.com/
Case report: a successful pregnancy in hemophilia A
Yong, J., & Toh, C. -H. (2018). Case report: a successful pregnancy in hemophilia A. In HAEMOPHILIA Vol. 24 (pp. 94). Retrieved from https://www.webofscience.com/
Haematology Speciality Trainees Driving NIHR Clinical Research: The North-West Coast Clinical Research Network (NWC CRN) Experience
Loizou, E., Karpha, I., Nicholson, T., Toh, C. -H., & Dutt, T. (2018). Haematology Speciality Trainees Driving NIHR Clinical Research: The North-West Coast Clinical Research Network (NWC CRN) Experience. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 181 (pp. 168). Retrieved from https://www.webofscience.com/
Neutrophil Extracellular Traps (NETs) formation in Patients newly diagnosed with Myeloma: Findings from the Thromboprophylaxis in Multiple Myeloma (TiMM) Study
Sayar, Z., Abrams, S. T., Alsabani, M., Czuprynska, J., Benjamin, R., Patel, J. P., . . . Toh, C. H. (2018). Neutrophil Extracellular Traps (NETs) formation in Patients newly diagnosed with Myeloma: Findings from the Thromboprophylaxis in Multiple Myeloma (TiMM) Study. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 181 (pp. 140-141). Retrieved from https://www.webofscience.com/
2017
Phenotypic Characterization of <i>EIF2AK4</i> Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension.
Hadinnapola, C., Bleda, M., Haimel, M., Screaton, N., Swift, A., Dorfmüller, P., . . . Morrell, N. W. (2017). Phenotypic Characterization of <i>EIF2AK4</i> Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension.. Circulation, 136(21), 2022-2033. doi:10.1161/circulationaha.117.028351
Systemic histone release disrupts plasmalemma and contributes to necrosis in acute pancreatitis
Szatmary, P., Liu, T., Abrams, S. T., Voronina, S., Wen, L., Chvanov, M., . . . Sutton, R. (2017). Systemic histone release disrupts plasmalemma and contributes to necrosis in acute pancreatitis. PANCREATOLOGY, 17(6), 884-892. doi:10.1016/j.pan.2017.10.002
Extracellular histones inhibit complement activation through interactions with complement component C4b
Qaddoori, Y., Abrams, S. T., Su, D., Liu, T., Alhamdi, Y., Wang, G., & Toh, C. -H. (2017). Extracellular histones inhibit complement activation through interactions with complement component C4b. In MOLECULAR IMMUNOLOGY Vol. 89 (pp. 132). doi:10.1016/j.molimm.2017.06.067
Accuracy of circulating histones in predicting persistent organ failure and mortality in patients with acute pancreatitis
Liu, T., Huang, W., Szatmary, P., Abrams, S. T., Alhamdi, Y., Lin, Z., . . . Toh, C. H. (2017). Accuracy of circulating histones in predicting persistent organ failure and mortality in patients with acute pancreatitis. BRITISH JOURNAL OF SURGERY, 104(9), 1215-1225. doi:10.1002/bjs.10538
Circulating histones associate with severity and play important roles in acute pancreatitis
Lin, Z., Cheng, Z., Liu, T., Wang, G., Sutton, R., & Toh, C. -H. (2017). Circulating histones associate with severity and play important roles in acute pancreatitis. Pancreatology, 17(3), S33. doi:10.1016/j.pan.2017.05.102
143 The roles and mechanisms of pore-forming toxins in cardiac injury
Wang, G., Alhamdi, Y., & Toh, C. -H. (2017). 143 The roles and mechanisms of pore-forming toxins in cardiac injury. Heart, 103(Suppl 5), A107.1-A107. doi:10.1136/heartjnl-2017-311726.142
Granulocyte colony-stimulating factor (G-CSF) increases histone-complexed DNA plasma levels in healthy volunteers
Schoergenhofer, C., Schwameis, M., Wohlfarth, P., Brostjan, C., Abrams, S. T., Toh, C. -H., & Jilma, B. (2017). Granulocyte colony-stimulating factor (G-CSF) increases histone-complexed DNA plasma levels in healthy volunteers. CLINICAL AND EXPERIMENTAL MEDICINE, 17(2), 243-249. doi:10.1007/s10238-016-0413-6
Elevated Circulating Histones Associate With Multiple Organ Dysfunction Syndromes in Acute Pancreatitis
Liu, T., Huang, W., Abrams, S., Wang, L., Szatmary, P., Alhamdi, Y., . . . Sutton, R. (2016). Elevated Circulating Histones Associate With Multiple Organ Dysfunction Syndromes in Acute Pancreatitis. PANCREAS, 45(10), 1520. Retrieved from https://www.webofscience.com/
Biallelic Mutation of <i>ARHGEF18</i>, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration
Arno, G., Carss, K. J., Hull, S., Zihni, C., Robson, A. G., Fiorentino, A., . . . Webster, A. R. (2017). Biallelic Mutation of <i>ARHGEF18</i>, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration. AMERICAN JOURNAL OF HUMAN GENETICS, 100(2), 334-342. doi:10.1016/j.ajhg.2016.12.014
Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation (vol 36, pg 505, 2016)
Toh, C. -H., Alhamdi, Y., & Abrams, S. T. (2017). Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation (vol 36, pg 505, 2016). ANNALS OF LABORATORY MEDICINE, 37(1), 95. doi:10.3343/alm.2017.37.1.95
Recent advances in pathophysiology of disseminated intravascular coagulation: the role of circulating histones and neutrophil extracellular traps.
Alhamdi, Y., & Toh, C. -H. (2017). Recent advances in pathophysiology of disseminated intravascular coagulation: the role of circulating histones and neutrophil extracellular traps.. F1000Research, 6, 2143. doi:10.12688/f1000research.12498.1
THE ROLES AND MECHANISMS OF PORE-FORMING TOXINS IN CARDIAC INJURY
Wang, G., Alhamdi, Y., & Toh, C. -H. (2017). THE ROLES AND MECHANISMS OF PORE-FORMING TOXINS IN CARDIAC INJURY. In HEART Vol. 103 (pp. A107). Retrieved from https://www.webofscience.com/
2016
Role of Coagulation Factor Concentrates in the Operating Room
Alhamdi, Y. A. T., & Toh, C. H. (n.d.). Role of Coagulation Factor Concentrates in the Operating Room. Europeam Medical Journal.
Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation
Toh, C. -H., Alhamdi, Y., & Abrams, S. T. (2016). Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation. ANNALS OF LABORATORY MEDICINE, 36(6), 505-512. doi:10.3343/alm.2016.36.6.505
Disseminated intravascular coagulation
Gando, S., Levi, M., & Toh, C. -H. (2016). Disseminated intravascular coagulation. In Unknown Book (Vol. 2). doi:10.1038/nrdp.2016.37
Disseminated intravascular coagulation.
Gando, S., Levi, M., & Toh, C. -H. (2016). Disseminated intravascular coagulation.. Nature reviews. Disease primers, 2, 16037. doi:10.1038/nrdp.2016.37
Circulating histones accurately predict persistent organ failure and mortality in patients with acute pancreatitis within 24 h of admission
Liu, T., Huang, W., Szatmary, P., Abrams, S., Alhamdi, Y., Lin, Z., . . . Toh, C. -H. (2016). Circulating histones accurately predict persistent organ failure and mortality in patients with acute pancreatitis within 24 h of admission. Pancreatology, 16(3), S100-S101. doi:10.1016/j.pan.2016.05.338
The role of extracellular histones in haematological disorders
Alhamdi, Y., & Toh, C. -H. (2016). The role of extracellular histones in haematological disorders. BRITISH JOURNAL OF HAEMATOLOGY, 173(5), 805-811. doi:10.1111/bjh.14077
Circulating Histone Concentrations Differentially Affect the Predominance of Left or Right Ventricular Dysfunction in Critical Illness
Alhamdi, Y., Zi, M., Abrams, S., Liu, T., Su, D., Welters, I., . . . Toh, C. -H. (2016). Circulating Histone Concentrations Differentially Affect the Predominance of Left or Right Ventricular Dysfunction in Critical Illness. Critical Care Medicine, 44(05), e278-e288. doi:10.1097/CCM.0000000000001413
36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016.
36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. (2016). Critical care (London, England), 20(Suppl 2), 94. doi:10.1186/s13054-016-1208-6
Disseminated intravascular coagulation (dic) is underdiagnosed in critically ill patients: do we need d-dimer measurements?
Iqbal, R., Alhamdi, Y., Venugopal, N., Abrams, S., Downey, C., Toh, C. H., & Welters, I. D. M. (2016). Disseminated intravascular coagulation (dic) is underdiagnosed in critically ill patients: do we need d-dimer measurements?. In Critical Care Vol. 20 (pp. P127). Brussels: BioMed Central.
Histone-Associated Thrombocytopenia in Patients Who Are Critically Ill
Alhamdi, Y., Abrams, S., Lane, S., Wang, G., & Toh, C. -H. (2016). Histone-Associated Thrombocytopenia in Patients Who Are Critically Ill. JAMA: Journal of the American Medical Association, 315(8), 817-819. doi:10.1001/jama.2016.0136
Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding (vol 13, pg 1653, 2015)
Moxon, C. A., Chisala, N. V., Mzikamanda, R., MacCormick, I., Harding, S., Downey, C., . . . Toh, C. H. (2016). Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding (vol 13, pg 1653, 2015). JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 14(2), 415. doi:10.1111/jth.13233
A multi-factorial analysis of response to warfarin in a UK prospective cohort
Bourgeois, S., Jorgensen, A., Zhang, E. J., Hanson, A., Gillman, M. S., Bumpstead, S., . . . Pirmohamed, M. (2016). A multi-factorial analysis of response to warfarin in a UK prospective cohort. Genome Medicine: medicine in the post-genomic era, 8. doi:10.1186/s13073-015-0255-y
36th International Symposium on Intensive Care and Emergency Medicine (vol 20, 94, 2016)
Iqbal, R., Alhamdi, Y., Venugopal, N., Abrams, S., Downey, C., Toh, C. H., & Welters, I. D. (2016). 36th International Symposium on Intensive Care and Emergency Medicine (vol 20, 94, 2016). CRITICAL CARE, 20. doi:10.1186/s13054-016-1358-6
Arterial ischemic stroke in HIV Defining and classifying etiology for research studies
Benjamin, L. A., Bryer, A., Lucas, S., Stanley, A., Allain, T. J., Joekes, E., . . . Solomon, T. (2016). Arterial ischemic stroke in HIV Defining and classifying etiology for research studies. NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 3(4). doi:10.1212/NXI.0000000000000254
EXTRACELLULAR HISTONES ENHANCE FACTOR XA MEDIATED PROTHROMBIN ACTIVATION WITHOUT PHOSPHOLIPID REQUIREMENT
Sahraoui, Y., Abrams, S., Su, D., Alhamdi, Y., Foley, J., Wang, G., & Toh, C. H. (2016). EXTRACELLULAR HISTONES ENHANCE FACTOR XA MEDIATED PROTHROMBIN ACTIVATION WITHOUT PHOSPHOLIPID REQUIREMENT. In HAEMATOLOGICA Vol. 101 (pp. 310). Retrieved from https://www.webofscience.com/
Early prediction of major clinical outcomes of patients with acute pancreatitis by circulating histones
Liu, T., Huang, W., Szatmary, P., Abrams, S. T., Greenhalf, W., Welters, I., . . . Toh, C. H. (2016). Early prediction of major clinical outcomes of patients with acute pancreatitis by circulating histones. Pancreatology, 16(1), S34. doi:10.1016/j.pan.2015.12.107
Extracellular histones promote prothrombin activation in the absence of phospholipids
Sahraoui, Y., Abrams, S. T., Su, D., Alhamdi, Y., Foley, J., Wang, G., & Toh, C. H. (2016). Extracellular histones promote prothrombin activation in the absence of phospholipids. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 173 (pp. 19). Retrieved from https://www.webofscience.com/
Histone-associated thrombocytopaenia is a significant cause of thrombocytopaenia in critical illness
Alhamdi, Y., Abrams, S. T., Lane, S., Wang, G., & Toh, C. H. (2016). Histone-associated thrombocytopaenia is a significant cause of thrombocytopaenia in critical illness. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 173 (pp. 19). Retrieved from https://www.webofscience.com/
2015
Acquired coagulation disorders
Collins, P. W., Thachil, J., & Toh, C. -H. (2016). Acquired coagulation disorders. In POSTGRADUATE HAEMATOLOGY, 7TH EDITION (pp. 743-760). Retrieved from https://www.webofscience.com/
Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis
Ou, X., Cheng, Z., Liu, T., Tang, Z., Huang, W., Szatmary, P., . . . Wang, G. (2015). Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis. Pancreas, 44(7), 1089-1095. doi:10.1097/MPA.0000000000000416
Circulating histones are major mediators of cardiac injury in patients with sepsis
Alhamdi, Y., Abrams, S. T., Cheng, Z., Jing, S., Su, D., Liu, Z., . . . Toh,, C. -H. (2015). Circulating histones are major mediators of cardiac injury in patients with sepsis. Critical Care Medicine, 43(10), 2094-2103. doi:10.1097/CCM.0000000000001162
doi:10.1186/2197-425x-3-s1-a85
Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding
Moxon, C. A., Chisala, N. V., Mzikamanda, R., MacCormick, I., Harding, S., Downey, C., . . . Toh, C. -H. (2015). Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13(9), 1653-1664. doi:10.1111/jth.13060
Circulating histones contribute to acute respiratory distress syndrome in acute pancreatitis
Liu, T., Abrams, S., Szatmary, P., Cheng, Z., Huang, W., Ou, X., . . . Toh, C. -H. (2015). Circulating histones contribute to acute respiratory distress syndrome in acute pancreatitis. Pancreatology, 15(3), S63. doi:10.1016/j.pan.2015.05.242
Thrombotic thrombocytopenic purpura specialist centres: providing better outcomes for patients with rare but life-threatening conditions.
Dutt, T., Martlew, V., Toh, C. H., & Jones, C. K. (2015). Thrombotic thrombocytopenic purpura specialist centres: providing better outcomes for patients with rare but life-threatening conditions.. Clinical medicine (London, England), 15 Suppl 3, s21. doi:10.7861/clinmedicine.15-3-s21
Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection
Alhamdi, Y., Neill, D., Abrams, S., Malak, H., Yahya, R., Barrett-Jolley, R., . . . Toh, C. -H. (2015). Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection. PLoS Pathogens, 11(5). doi:10.1371/journal.ppat.1004836
Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis
Ou, X., Cheng, Z., Liu, T., Tang, Z., Huang, W., Szatmary, P., . . . Wang, G. (2015). Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis.
Circulating Histones Target Acinar Cells and Exacerbate Injury in Experimental Acute Pancreatitis
Szatmary, P., Liu, T., Abrams, S., Wen, L., Huang, W., Wang, G., . . . Sutton, R. (2015). Circulating Histones Target Acinar Cells and Exacerbate Injury in Experimental Acute Pancreatitis. PANCREAS, 44(8), 1418. Retrieved from https://www.webofscience.com/
Circulating histones disturb intracellular calcium homeostasis and cause calcium overload to induce cardiovascular abnormalities in sepsis
Alhamdi, Y., Abrams, S. T., Zi, M., Welters, I., Cartwright, E. J., Wang, G., & Toh, C. -H. (2015). Circulating histones disturb intracellular calcium homeostasis and cause calcium overload to induce cardiovascular abnormalities in sepsis. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13, 159. Retrieved from https://www.webofscience.com/
Developing a laboratory-based score to predict mortality in patients admitted to the ICU
Iqbal, A., Welters, I., Kolamunnage-Dona, R., Toh, C., & Downey, C. (2015). Developing a laboratory-based score to predict mortality in patients admitted to the ICU. Critical care (London, England), 19(Suppl 1), P547. doi:10.1186/cc14627
Early Prediction of Major Clinical Outcomes of Patients With Acute Pancreatitis by Circulating Histones
Liu, T., Huang, W., Szatmary, P., Abrams, S. T., Greenhalf, W., Welters, I., . . . Toh, C. H. (2015). Early Prediction of Major Clinical Outcomes of Patients With Acute Pancreatitis by Circulating Histones. PANCREAS, 44(8), 1393. Retrieved from https://www.webofscience.com/
Exploring the psychosocial implications of living and coping with sickle cell crisis: an interpretative phenomenological analysis
Barrow, E., Houghton, A., Simcox, D., & Toh, C. H. (2015). Exploring the psychosocial implications of living and coping with sickle cell crisis: an interpretative phenomenological analysis. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 169 (pp. 103-104). Retrieved from https://www.webofscience.com/
Histone-associated thrombocytopenia: a new cause of thrombocytopenia in critically ill patients
Alhamdi, Y., Abrams, S. T., Welters, I., Wang, G., & Toh, C. -H. (2015). Histone-associated thrombocytopenia: a new cause of thrombocytopenia in critically ill patients. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13, 94. Retrieved from https://www.webofscience.com/
Neuro-imaging does not correlate with disease severity in acute thrombotic thrombocytopenia purpura (TTP), but may predict long term sequelae
Karpha, I., Kay-Jones, C., Burgiss, J., Martlew, V., Toh, C. H., Fitzsimmons, P., & Dutt, T. (2015). Neuro-imaging does not correlate with disease severity in acute thrombotic thrombocytopenia purpura (TTP), but may predict long term sequelae. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13, 470. Retrieved from https://www.webofscience.com/
Patients with suspected TTP should be acutely managed in a critical care setting
Burgess, J. L., Jones, C. K., Karpha, I., Martlew, V. J., Toh, C. H., & Dutt, T. (2015). Patients with suspected TTP should be acutely managed in a critical care setting. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 169 (pp. 45). Retrieved from https://www.webofscience.com/
Short and long term neurological complications of thrombotic thrombocytopenic purpura (TTP)
Karpha, I., Kay-Jones, C., Burgiss, J., Martlew, V. J., Toh, C. H., Fitzsimmons, P., & Dutt, T. (2015). Short and long term neurological complications of thrombotic thrombocytopenic purpura (TTP). In BRITISH JOURNAL OF HAEMATOLOGY Vol. 169 (pp. 48). Retrieved from https://www.webofscience.com/
doi:10.1186/2197-425x-3-s1-a138
doi:10.1186/2197-425x-3-s1-a913
2014
Protective Effects of Carbon Monoxide-Releasing Molecule-2 on the Barrier Function of Intestinal Epithelial Cells
Mu, X., Pan, C., Zheng, S., Alhamdi, Y., Sun, B., Shi, Q., . . . Wang, G. (2014). Protective Effects of Carbon Monoxide-Releasing Molecule-2 on the Barrier Function of Intestinal Epithelial Cells. PLOS ONE, 9(8). doi:10.1371/journal.pone.0104032
A Master Class for European Hematology
Toh, C. H., Strivens, J., Guenova, M., & Modok, S. (2014). A Master Class for European Hematology. HAEMATOLOGICA, 99(6), 949-951. doi:10.3324/haematol.2014.107540
Survey of professional competence in hematology in Europe
Lindberg, E. H., Almeida, A., Enoksson, F., de Wit, T. D., Strivens, J., Naeve, A., & Toh, C. -H. (2014). Survey of professional competence in hematology in Europe. HAEMATOLOGICA, 99(3), 404-408. doi:10.3324/haematol.2014.104299
Persistent Endothelial Activation and Inflammation After <i>Plasmodium falciparum</i> Infection in Malawian Children
Moxon, C. A., Chisala, N. V., Wassmer, S. C., Taylor, T. E., Seydel, K. B., Molyneux, M. E., . . . Heyderman, R. S. (2014). Persistent Endothelial Activation and Inflammation After <i>Plasmodium falciparum</i> Infection in Malawian Children. JOURNAL OF INFECTIOUS DISEASES, 209(4), 610-615. doi:10.1093/infdis/jit419
Role of sequestration-induced loss of protein C receptors in coagulation and inflammation in cerebral malaria
Moxon, C., Wassmer, S., Milner, D. J., Chisala, N., Taylor, T., Seydel, K., . . . Heyderman, R. (2014). Role of sequestration-induced loss of protein C receptors in coagulation and inflammation in cerebral malaria. In LANCET Vol. 383 (pp. 75). Retrieved from https://www.webofscience.com/
HYPOMAGNESAEMIA IN CRITICAL CARE
Homer, L. E., Kolammunage-Dona, R., Steele, T., Toh, C. -H., Downey, C., & Welters, I. D. (2014). HYPOMAGNESAEMIA IN CRITICAL CARE. In INTENSIVE CARE MEDICINE Vol. 40 (pp. S196-S197). Retrieved from https://www.webofscience.com/
LOW SERUM PHOSPHATE LEVELS IN CRITICAL ILLNESS
Agarwal, K., Kolammunage-Dona, R., Steele, T., Toh, C. H., Downey, C., & Welters, I. D. (2014). LOW SERUM PHOSPHATE LEVELS IN CRITICAL ILLNESS. In INTENSIVE CARE MEDICINE Vol. 40 (pp. S178). Retrieved from https://www.webofscience.com/
SEVERE HYPONATRAEMIA IN CRITICAL ILLNESS
Lee, S. D., Gilmartin, M., Nee, A., Steele, T., Toh, C. H., & Welters, I. (2014). SEVERE HYPONATRAEMIA IN CRITICAL ILLNESS. In INTENSIVE CARE MEDICINE Vol. 40 (pp. S196). Retrieved from https://www.webofscience.com/
Safe implementation of the new oral anticoagulants (NOACs) requires patient monitoring
Loizou, E., Toh, C. -H., & Dutt, T. (2014). Safe implementation of the new oral anticoagulants (NOACs) requires patient monitoring. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 12, 9. Retrieved from https://www.webofscience.com/
The Role of Neutrophil Extracellular Traps in Acute Pancreatitis
Szatmary, P., Liu, T., Wen, L., Huang, W., Awais, M., Wang, G., . . . Sutton, R. (2014). The Role of Neutrophil Extracellular Traps in Acute Pancreatitis. PANCREAS, 43(8), 1413. Retrieved from https://www.webofscience.com/
Use of Citrullinated Histones and Circulating Nucleosomes in Early Prediction of Organ Failure in Acute Pancreatitis
Szatmary, P., Liu, T., Huang, W., Wang, G., Latawiec, D., Davies, K., . . . Sutton, R. (2014). Use of Citrullinated Histones and Circulating Nucleosomes in Early Prediction of Organ Failure in Acute Pancreatitis. PANCREAS, 43(8), 1413. Retrieved from https://www.webofscience.com/
2013
A Randomized Trial of Genotype-Guided Dosing of Warfarin
Pirmohamed, M., Burnside, G., Eriksson, N., Jorgensen, A. L., Toh, C. H., Nicholson, T., . . . Wadelius, M. (2013). A Randomized Trial of Genotype-Guided Dosing of Warfarin. NEW ENGLAND JOURNAL OF MEDICINE, 369(24), 2294-2303. doi:10.1056/NEJMoa1311386
A Randomized Trial of Genotype-Guided Dosing of Warfarin
Pirmohamed, M., Burnside, G., Eriksson, N., Jorgensen, A. L., Toh, C. H., Nicholson, T., . . . Wadelius, M. (2013). A Randomized Trial of Genotype-Guided Dosing of Warfarin. New England Journal of Medicine, 369(24), 2294-2303. doi:10.1056/nejmoa1311386
Current consideration and management of disseminated intravascular coagulation.
Toh, C. H., & Alhamdi, Y. (2013). Current consideration and management of disseminated intravascular coagulation.. Hematology. American Society of Hematology. Education Program, 2013, 286-291. doi:10.1182/asheducation-2013.1.286
Histone-Induced Lung Injury and Coagulation Activation Are Reduced By C-Reactive Protein In The Acute Phase Response
Abrams, S. T., Zhang, N., Wang, G., & Toh, C. -H. (2013). Histone-Induced Lung Injury and Coagulation Activation Are Reduced By C-Reactive Protein In The Acute Phase Response. In BLOOD Vol. 122. doi:10.1182/blood.V122.21.457.457
Human CRP Defends against the Toxicity of Circulating Histones
Abrams, S. T., Zhang, N., Dart, C., Wang, S. S., Thachil, J., Guan, Y., . . . Toh, C. -H. (2013). Human CRP Defends against the Toxicity of Circulating Histones. JOURNAL OF IMMUNOLOGY, 191(5), 2495-2502. doi:10.4049/jimmunol.1203181
Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children
Moxon, C. A., Wassmer, S. C., Milner, D. A. J., Chisala, N. V., Taylor, T. E., Seydel, K. B., . . . Heyderman, R. S. (2013). Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children. BLOOD, 122(5), 842-851. doi:10.1182/blood-2013-03-490219
A European strategy for targeted education in hematology.
Strivens, J., Hellström-Lindberg, E., Bjerrum, O. W., & Toh, C. -H. (2013). A European strategy for targeted education in hematology.. Haematologica, 98(7), 1000-1002. doi:10.3324/haematol.2013.090423
Assessment and clinical course of hypocalcemia in critical illness
Steele, T., Kolamunnage-Dona, R., Downey, C., Toh, C. -H., & Welters, I. (2013). Assessment and clinical course of hypocalcemia in critical illness. CRITICAL CARE, 17(3). doi:10.1186/cc12756
Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines.
Wada, H., Thachil, J., Di Nisio, M., Mathew, P., Kurosawa, S., Gando, S., . . . The Scientific Standardization Committee on DIC of the International Society on Thrombosis Haemostasis. (2013). Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines.. Journal of thrombosis and haemostasis : JTH. doi:10.1111/jth.12155
Circulating Histones Are Mediators of Trauma-associated Lung Injury
Abrams, S. T., Zhang, N., Manson, J., Liu, T., Dart, C., Baluwa, F., . . . Toh, C. -H. (2013). Circulating Histones Are Mediators of Trauma-associated Lung Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 187(2), 160-169. doi:10.1164/rccm.201206-1037OC
A Randomized Trial Comparing Genotype-Guided Dosing of Warfarin to Standard Dosing: The EU Pharmacogenetics of Anticoagulant Therapy (EU-PACT) Warfarin Study
Pirmohamed, M., Burnside, G., Stoddern, J., Prince, C., Toh, C. H., Nicholson, T., . . . Wadelius, M. (2013). A Randomized Trial Comparing Genotype-Guided Dosing of Warfarin to Standard Dosing: The EU Pharmacogenetics of Anticoagulant Therapy (EU-PACT) Warfarin Study. CIRCULATION, 128(24), 2710-2711. Retrieved from https://www.webofscience.com/
Activated protein C (APC) and thrombin modulate cardiomyocytes contractility via a protease activated receptor-1 (PAR1)-cardiac troponin I (CTI) pathway
Alhamdi, Y., Wang, G., & Toh, C. -H. (2013). Activated protein C (APC) and thrombin modulate cardiomyocytes contractility via a protease activated receptor-1 (PAR1)-cardiac troponin I (CTI) pathway. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 38). Retrieved from https://www.webofscience.com/
Acute phase proteins reduce histone-induced platelet aggregation and coagulation activation
Abrams, S. T., Manson, J., Liu, T., Baluwa, F., Barrera, V., Brohi, K., . . . Toh, C. H. (2013). Acute phase proteins reduce histone-induced platelet aggregation and coagulation activation. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 22). Retrieved from https://www.webofscience.com/
Adherence and variability in warfarin dose requirements: assessment in a prospective cohort
Jorgensen, A. L., Hughes, D. A., Hanson, A., van Eker, D., Toh, C. H., Pirmohamed, M., & Williamson, P. R. (2013). Adherence and variability in warfarin dose requirements: assessment in a prospective cohort. PHARMACOGENOMICS, 14(2), 151-163. doi:10.2217/PGS.12.199
Albumin-adjusted calcium concentration should not be used to identify hypocalcaemia in critical illness
Steele, T., Kolamunnage-Dona, R., Downey, C., Toh, C., & Welters, I. (2013). Albumin-adjusted calcium concentration should not be used to identify hypocalcaemia in critical illness. Critical care (London, England), 17(Suppl 2), P446. doi:10.1186/cc12384
Circulating histone-induced thrombosis leads to circulatory and respiratory failure
Abrams, S. T., Manson, J., Liu, T., Alhamdi, Y., Brohi, K., Wang, G., & Toh, C. H. (2013). Circulating histone-induced thrombosis leads to circulatory and respiratory failure. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 128). Retrieved from https://www.webofscience.com/
Improving specificity for diagnosing heparin-induced thrombocytopenia through repeated testing
Vithanarachchi, S., Saminaden, L., Downey, C., Toh, C. H., & Dutt, T. (2013). Improving specificity for diagnosing heparin-induced thrombocytopenia through repeated testing. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 542). Retrieved from https://www.webofscience.com/
Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children.
Moxon, C. A., Wassmer, S. C., Milner, D. A. J., Chisala, N. V., Taylor, T. E., Seydel, K. B., . . . Heyderman, R. S. (2013). Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children.. Blood, 122(5), 842-845. doi:10.1182/blood-2013-03-490219
Loss of protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria
Moxon, C. A., Wassmer, S. C., Milner, D. A., Chisala, N. V., Taylor, T. E., Seydel, K. B., . . . Heyderman, R. S. (2013). Loss of protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 4). Retrieved from https://www.webofscience.com/
Platelet surface high mobility group box protein-1 binds receptor for advanced glycation endproducts in plasma or on monocytes in septic patients
Thachil, J., Barrera, V., Djebabri, B., Abrams, S. T., Wang, G., & Toh, C. H. (2013). Platelet surface high mobility group box protein-1 binds receptor for advanced glycation endproducts in plasma or on monocytes in septic patients. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 71). Retrieved from https://www.webofscience.com/
2012
Comparison of disseminated intravascular coagulation in trauma with coagulopathy of trauma/acute coagulopathy of trauma-shock.
Gando, S., Wada, H., Kim, H. K., Kurosawa, S., Nielsen, J. D., Thachil, J., . . . Scientific and Standardization Committee on DIC of the ISTH. (2012). Comparison of disseminated intravascular coagulation in trauma with coagulopathy of trauma/acute coagulopathy of trauma-shock.. Journal of thrombosis and haemostasis : JTH, 10(12), 2593-2595. doi:10.1111/jth.12011
415 Activated Protein C (APC) Alleviates Endoplasmic Reticulum (ER) Stress and ER Stress-Linked Apoptosis in Endothelial Cells
Alhamdi, Y. A., Wang, G., & Toh, C. (2012). 415 Activated Protein C (APC) Alleviates Endoplasmic Reticulum (ER) Stress and ER Stress-Linked Apoptosis in Endothelial Cells. Canadian Journal of Cardiology, 28(5), S255. doi:10.1016/j.cjca.2012.07.390
The withdrawal of Activated Protein C from the use in patients with severe sepsis and DIC [Amendment to the BCSH guideline on disseminated intravascular coagulation].
Thachil, J., Toh, C. H., Levi, M., & Watson, H. G. (2012). The withdrawal of Activated Protein C from the use in patients with severe sepsis and DIC [Amendment to the BCSH guideline on disseminated intravascular coagulation].. British journal of haematology, 157(4), 493-494. doi:10.1111/j.1365-2141.2011.09019.x
Current concepts in the management of disseminated intravascular coagulation.
Thachil, J., & Toh, C. H. (2012). Current concepts in the management of disseminated intravascular coagulation.. Thrombosis research, 129 Suppl 1, S54-S59. doi:10.1016/s0049-3848(12)70017-8
2011
Lipoproteins, statins and septic haematology patients.
Thachil, J., Abrams, S., Downey, C., & Toh, C. H. (2011). Lipoproteins, statins and septic haematology patients.. British journal of haematology, 155(1), 122-123. doi:10.1111/j.1365-2141.2011.08642.x
Reduction of circulating histone toxicity is a major function of C-reactive protein after extensive tissue damage
The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis
Perez-Casal, M., Thompson, V., Downey, C., Welters, I., Wyncoll, D., Thachil, J., & Toh, C. H. (2011). The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis. CRITICAL CARE, 15(4). doi:10.1186/cc10356
Diagnostic efficacy of activated partial thromboplastin time waveform and procalcitonin analysis in pediatric meningococcal sepsis
Paize, F., Carrol, E., Downey, C., Parry, C. M., Green, G., Diggle, P., . . . Toh, C. -H. (2011). Diagnostic efficacy of activated partial thromboplastin time waveform and procalcitonin analysis in pediatric meningococcal sepsis. PEDIATRIC CRITICAL CARE MEDICINE, 12(6), E322-E329. doi:10.1097/PCC.0b013e3182231034
Diagnostic efficacy of activated partial thromboplastin time waveform and procalcitonin analysis in pediatric meningococcal sepsis.
Paize, F., Carrol, E., Downey, C., Parry, C. M., Green, G., Diggle, P., . . . Toh, C. H. (2011). Diagnostic efficacy of activated partial thromboplastin time waveform and procalcitonin analysis in pediatric meningococcal sepsis.. Pediatr Crit Care Med, 12(6), e322-e329.
The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis
Pérez-Casal, M., Thompson, V., Downey, C., Welters, I., Wyncoll, D., Thachil, J., & Toh, C. H. (n.d.). The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis. Critical Care, 15(4). doi:10.1186/cc10356
2010
Accuracy of platelet counting by automated hematologic analyzers in acute leukemia and disseminated intravascular coagulation: potential effects of platelet activation.
Kim, S. Y., Kim, J. -E., Kim, H. K., Han, K. -S., & Toh, C. H. (2010). Accuracy of platelet counting by automated hematologic analyzers in acute leukemia and disseminated intravascular coagulation: potential effects of platelet activation.. American journal of clinical pathology, 134(4), 634-647. doi:10.1309/ajcp88jylrcsrxpp
Modified non-overt DIC diagnostic criteria predict the early phase of overt-DIC.
Wada, H., Hatada, T., Okamoto, K., Uchiyama, T., Kawasugi, K., Mayumi, T., . . . Japanese Society of Thrombosis Hemostasis/DIC subcommittee. (2010). Modified non-overt DIC diagnostic criteria predict the early phase of overt-DIC.. American journal of hematology, 85(9), 691-694. doi:10.1002/ajh.21783
Application of the international normalized ratio in the scoring system for disseminated intravascular coagulation.
Kim, H. K., Hong, K. H., Toh, C. H., & Scientific and Standardization Committee on DIC of The International Society on THrombosis and Haemostasis. (2010). Application of the international normalized ratio in the scoring system for disseminated intravascular coagulation.. Journal of thrombosis and haemostasis : JTH, 8(5), 1116-1118. doi:10.1111/j.1538-7836.2010.03834.x
Appropriate use of D-dimer in hospital patients.
Thachil, J., Fitzmaurice, D. A., & Toh, C. H. (2010). Appropriate use of D-dimer in hospital patients.. The American journal of medicine, 123(1), 17-19. doi:10.1016/j.amjmed.2009.09.011
Non-malignant haematology research in the UK: looking forward to new opportunities.
Collins, P. W., Baglin, T. P., Dang, R., Evans, G., Greaves, M., Laffan, M., . . . Toh, C. H. (2010). Non-malignant haematology research in the UK: looking forward to new opportunities.. Br J Haematol, 150(6), 732-736.
2009
Effects of <i>CYP4F2</i> genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy
Zhang, J. E., Jorgensen, A. L., Alfirevic, A., Williamson, P. R., Toh, C. H., Park, B. K., & Pirmohamed, M. (2009). Effects of <i>CYP4F2</i> genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy. PHARMACOGENETICS AND GENOMICS, 19(10), 781-789. doi:10.1097/FPC.0b013e3283311347
Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study
Jorgensen, A. L., Al-Zubiedi, S., Zhang, J. E., Keniry, A., Hanson, A., Hughes, D. A., . . . Pirmohamed, M. (2009). Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study. PHARMACOGENETICS AND GENOMICS, 19(10), 800-812. doi:10.1097/FPC.0b013e3283317ab5
Disseminated intravascular coagulation in obstetric disorders and its acute haematological management.
Thachil, J., & Toh, C. -H. (2009). Disseminated intravascular coagulation in obstetric disorders and its acute haematological management.. Blood reviews, 23(4), 167-176. doi:10.1016/j.blre.2009.04.002
Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology.
Levi, M., Toh, C. H., Thachil, J., & Watson, H. G. (2009). Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology.. British journal of haematology, 145(1), 24-33. doi:10.1111/j.1365-2141.2009.07600.x
Microparticle-associated endothelial protein C receptor and the induction of cytoprotective and anti-inflammatory effects.
Pérez-Casal, M., Downey, C., Cutillas-Moreno, B., Zuzel, M., Fukudome, K., & Toh, C. H. (2009). Microparticle-associated endothelial protein C receptor and the induction of cytoprotective and anti-inflammatory effects.. Haematologica, 94(3), 387-394. doi:10.3324/haematol.13547
Guidelines for the diagnosis and management of disseminated intravascular coagulation.
Levi, M., Toh, C. H., Thachil, J., & Watson, H. G. (2009). Guidelines for the diagnosis and management of disseminated intravascular coagulation.. Br J Haematol, 94, 387-394.
2007
The formation of a Ca2+-dependent complex of C-reactive protein and very low density lipoprotein causes the biphasic transmittance waveform
Nesheim, M., Samis, J., Walker, J., Fischer, T., Tejidor, L., Jones, G., . . . Toh, C. H. (2007). The formation of a Ca2+-dependent complex of C-reactive protein and very low density lipoprotein causes the biphasic transmittance waveform. BMC Pharmacology, 7(S1). doi:10.1186/1471-2210-7-s1-p42
The scoring system of the Scientific and Standardisation Committee on Disseminated Intravascular Coagulation of the International Society on Thrombosis and Haemostasis: a 5-year overview.
Toh, C. H., & Hoots, W. K. (2007). The scoring system of the Scientific and Standardisation Committee on Disseminated Intravascular Coagulation of the International Society on Thrombosis and Haemostasis: a 5-year overview.. J Thromb Haemost, 5, 604-606.
2006
Disseminated intravascular coagulation
Toh, C. H. (2006). Disseminated intravascular coagulation. In N. S. Young, S. L. Gerson, & K. A. High (Eds.), Clinical Hematology (Vol. 1, pp. 1134-1143). Philadelphia: Elsevier.
2005
Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells.
Farahani, M., Treweeke, A. T., Toh, C. H., Till, K. J., Harris, R. J., Cawley, J. C., . . . Chen, H. (2005). Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells.. Leukemia, 19(4), 524-530. doi:10.1038/sj.leu.2403631
Activated protein C induces the release of microparticle-associated endothelial protein C receptor.
Pérez-Casal, M., Downey, C., Fukudome, K., Marx, G., & Toh, C. H. (2005). Activated protein C induces the release of microparticle-associated endothelial protein C receptor.. Blood, 105(4), 1515-1522. doi:10.1182/blood-2004-05-1896
Back to the future testing in disseminated intravascular coagulation
Toh, C. H., & Downey, C. (2005). Back to the future testing in disseminated intravascular coagulation. Unknown Journal, 16(8), 535-542.
Performance and prognostic importance of a new clinical and laboratory scoring system for identifying non-overt disseminated intravascular coagulation.
Toh, C. H., & Downey, C. (2005). Performance and prognostic importance of a new clinical and laboratory scoring system for identifying non-overt disseminated intravascular coagulation.. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 16(1), 69-74. doi:10.1097/00001721-200501000-00011
The use of clot waveform analysis in sepsis
Toh, C. H. (2005). The use of clot waveform analysis in sepsis. Unknown Journal, 4, 103-107.
Marx, G., Swaraj, S., Breen, A., Ritchie, G., Shenkin, A., Toh, C., & Leuwer, M. (2005). Unknown Title. Critical Care, 9(Suppl 1), P167. doi:10.1186/cc3230
2004
Thrombin activatable fibrinolysis inhibitor and its fibrinolytic effect in normal pregnancy.
Mousa, H. A., Downey, C., Alfirevic, Z., & Toh, C. -H. (2004). Thrombin activatable fibrinolysis inhibitor and its fibrinolytic effect in normal pregnancy.. Thrombosis and haemostasis, 92(5), 1025-1031. doi:10.1160/th04-06-0387
Temporal changes in factors associated with neutrophil elastase and coagulation in intensive care patients with a biphasic waveform and disseminated intravascular coagulation.
Samis, J. A., Stewart, K. A., Toh, C. H., Day, A., Downey, C., & Nesheim, M. E. (2004). Temporal changes in factors associated with neutrophil elastase and coagulation in intensive care patients with a biphasic waveform and disseminated intravascular coagulation.. Journal of thrombosis and haemostasis : JTH, 2(9), 1535-1544. doi:10.1111/j.1538-7836.2004.00826.x
Prothrombinase enhancement through quantitative and qualitative changes affecting very low density lipoprotein in complex with C-reactive protein.
Dennis, M. W., Downey, C., Brufatto, N., Nesheim, M. E., Stevenson, K., & Toh, C. H. (2004). Prothrombinase enhancement through quantitative and qualitative changes affecting very low density lipoprotein in complex with C-reactive protein.. Thrombosis and haemostasis, 91(3), 522-530. doi:10.1160/th03-08-0548
Computational aspects of protein functionality
Paton, R., & Toh, C. H. (2004). Computational aspects of protein functionality. Unknown Journal, 5, 85-90.
2003
Acquired activated protein C resistance may be a risk factor for recurrent fetal loss.
Dawood, F., Farquharson, R., Quenby, S., & Toh, C. H. (2003). Acquired activated protein C resistance may be a risk factor for recurrent fetal loss.. Fertility and sterility, 80(3), 649-650. doi:10.1016/s0015-0282(03)00972-5
A Longitudinal Study of Maternal Dose Response to Low Molecular Weight Heparin in Pregnancy
Sephton, V., Farquharson, R. G., Topping, J., Quenby, S. M., Cowan, C., Back, D. J., & Toh, C. H. (2003). A Longitudinal Study of Maternal Dose Response to Low Molecular Weight Heparin in Pregnancy. Obstetrics & Gynecology, 101(6), 1307-1311. doi:10.1097/00006250-200306000-00028
A longitudinal study of maternal dose response to low molecular weight heparin in pregnancy
Sephton, V., Farquharson, R. G., Topping, J., Quenby, S. M., Cowan, C., Back, D. J., & Toh, C. H. (2003). A longitudinal study of maternal dose response to low molecular weight heparin in pregnancy. OBSTETRICS AND GYNECOLOGY, 101(6), 1307-1311. doi:10.1016/S0029-7844(03)00340-5
Characterisation of thrombin activatable fibrinolysis inhibitor in normal and acquired haemostatic dysfunction
Toh, C. H. (2003). Characterisation of thrombin activatable fibrinolysis inhibitor in normal and acquired haemostatic dysfunction. Unknown Journal, 14(Suppl), 69-72.
DIC 2002: a review on disseminated intravascular coagulation
Toh, C. H., & Dennis, M. (2003). DIC 2002: a review on disseminated intravascular coagulation. Unknown Journal, 8(2), 65-71.
Disseminated intravascular coagulation: Old disease, new hope
Toh, C. H., & Dennis, M. (2003). Disseminated intravascular coagulation: Old disease, new hope. Unknown Journal, 327(7421), 974-977.
Early identification of sepsis and mortality risks through simple, rapid clot-waveform analysis - Implications of lipoprotein-complexed C reactive protein formation
Toh, C. H., Ticknor, L. O., Downey, C., Giles, A. R., Paton, R. C., & Wenstone, R. (2003). Early identification of sepsis and mortality risks through simple, rapid clot-waveform analysis - Implications of lipoprotein-complexed C reactive protein formation. INTENSIVE CARE MEDICINE, 29(1), 55-61. doi:10.1007/s00134-002-1557-2
Lipoprotein-complexed C reactive protein: new wave in sepsis management
Toh, C. H., & Breen, A. (2003). Lipoprotein-complexed C reactive protein: new wave in sepsis management. Unknown Journal, 13, 17-21.
2002
Biphasic transmittance waveform in the APTT coagulation assay is due to the formation of a Ca<SUP>++</SUP>-dependent complex of C-reactive protein with very-low-density lipoprotein and is a novel marker of impending disseminated intravascular coagulation
Toh, C. H., Samis, J., Downey, C., Walker, J., Becker, L., Brufatto, N., . . . Nesheim, M. (2002). Biphasic transmittance waveform in the APTT coagulation assay is due to the formation of a Ca<SUP>++</SUP>-dependent complex of C-reactive protein with very-low-density lipoprotein and is a novel marker of impending disseminated intravascular coagulation. BLOOD, 100(7), 2522-2529. doi:10.1182/blood.V100.7.2522
Lipoprotein-complexed C-reactive protein and the biphasic transmittance waveform in critically ill patients.
Nesheim, M., Samis, J., Walker, J., Becker, L., Brufatto, N., Fischer, T., . . . Toh, C. H. (2002). Lipoprotein-complexed C-reactive protein and the biphasic transmittance waveform in critically ill patients.. Blood reviews, 16 Suppl 1, S15-S22.
2001
Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation.
Taylor, F. B., Toh, C. H., Hoots, W. K., Wada, H., Levi, M., & Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). (2001). Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation.. Thrombosis and haemostasis, 86(5), 1327-1330.
The formation of a CA2+-dependent complex of C-reactive protein and very low density lipoprotein causes the biphasic transmittance waveform
Nesheim, M., Samis, J., Walker, J., Fischer, T., Tejidor, L., Jones, G., . . . Toh, C. H. (n.d.). The formation of a CA2+-dependent complex of C-reactive protein and very low density lipoprotein causes the biphasic transmittance waveform. BMC News and views, 1(S2). doi:10.1186/2048-4623-1-s2-007
Aberrant dimerization of von Willebrand factor as the result of mutations in the carboxy-terminal region: identification of 3 mutations in members of 3 different families with type 2A (phenotype IID) von Willebrand disease.
Enayat, M. S., Guilliatt, A. M., Surdhar, G. K., Jenkins, P. V., Pasi, K. J., Toh, C. H., . . . Hill, F. G. (2001). Aberrant dimerization of von Willebrand factor as the result of mutations in the carboxy-terminal region: identification of 3 mutations in members of 3 different families with type 2A (phenotype IID) von Willebrand disease.. Blood, 98(3), 674-680. doi:10.1182/blood.v98.3.674
Postnatal Screening for Thrombophilia in Women With Severe Pregnancy Complications
ALFIREVIC, Z., MOUSA, H. A., MARTLEW, V., BRISCOE, L., PEREZ-CASAL, M., & TOH, C. H. (2001). Postnatal Screening for Thrombophilia in Women With Severe Pregnancy Complications. Obstetrics & Gynecology, 97(5), 753-759. doi:10.1097/00006250-200105000-00021
2000
The value of the aptt waveform in predicting mortality and haemostatic dysfunction
Toh, C. H., Downey, C., Wenstone, R., Paton, R., & Ticknor, L. (2000). The value of the aptt waveform in predicting mortality and haemostatic dysfunction. Blood, 96(11 PART I).
In vitro and in vivo production of vascular endothelial growth factor by chronic lymphocytic leukemia cells.
Chen, H., Treweeke, A. T., West, D. C., Till, K. J., Cawley, J. C., Zuzel, M., & Toh, C. H. (2000). In vitro and in vivo production of vascular endothelial growth factor by chronic lymphocytic leukemia cells.. Blood, 96(9), 3181-3187.
What clinical significance has the presence of the homozygous G20210A prothrombin gene mutation in a healthy woman?
Martlew, V. J., Perez-Casal, M., Alfirevic, Z., & Toh, C. H. (2000). What clinical significance has the presence of the homozygous G20210A prothrombin gene mutation in a healthy woman?. Thrombosis and haemostasis, 84(2), 355-356.
Angiogenically active vascular endothelial growth factor is over-expressed in malignant human and rat prostate carcinoma cells.
Chen, H. J., Treweeke, A. T., Ke, Y. Q., West, D. C., & Toh, C. H. (2000). Angiogenically active vascular endothelial growth factor is over-expressed in malignant human and rat prostate carcinoma cells.. British journal of cancer, 82(10), 1694-1701. doi:10.1054/bjoc.2000.1122
1999
07 The differential regulation of the endothelial protein C receptor (EPCR) and thrombomodulin by inflammatory cytokines
Oates, M., Perez-Casal, M. M., Chen, H. J., & Toh, C. H. (1999). 07 The differential regulation of the endothelial protein C receptor (EPCR) and thrombomodulin by inflammatory cytokines. Blood Coagulation & Fibrinolysis, 10(8), 532. doi:10.1097/00001721-199912000-00019
1997
A cell model for studies on the function of the endothelial protein C receptor
Oates, M., Chen, H. J., & Toh, C. H. (1997). A cell model for studies on the function of the endothelial protein C receptor. Blood Coagulation & Fibrinolysis, 8(7), 463. doi:10.1097/00001721-199710000-00024
Evaluation of two simplified methods for genotyping hepatitis C virus
Khan, R. U., Tong, C. Y. W., Bloom, S., Gilmore, I. T., Toh, C. H., BoltonMaggs, P. H., . . . Hart, C. A. (1997). Evaluation of two simplified methods for genotyping hepatitis C virus. JOURNAL OF MEDICAL VIROLOGY, 52(1), 35-41. doi:3.0.CO;2-S">10.1002/(SICI)1096-9071(199705)52:1<35::AID-JMV7>3.0.CO;2-S