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Professor Cheng-Hock Toh
CBE, MBChB, MD, FRCP, FRCPath

Contact

C.H.Toh@liverpool.ac.uk

+44 (0)151 706 4324

+44 (0)151 795 9637

+44 (0)151 795 9637 Ext. 59637

Publications

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2024

Blood cell defence against pathogens

Abrams, S. T., & Toh, C. -H. (2024). Blood cell defence against pathogens. The Lancet Haematology, 11(10), e728. doi:10.1016/s2352-3026(24)00286-2

DOI
10.1016/s2352-3026(24)00286-2
Journal article

P.028: Optimisation of donation after circulatory death livers – removal of extracellular histones during normothermic perfusion and following whole blood reperfusion in an ex-situ porcine model.

Hussain Abbas, S., Dengu, F., Schofield, J., Wang, G., Morovat, A., Quaglia, A., . . . Friend, P. (2024). P.028: Optimisation of donation after circulatory death livers – removal of extracellular histones during normothermic perfusion and following whole blood reperfusion in an ex-situ porcine model.. Transplantation, 108(9S). doi:10.1097/01.tp.0001067024.19971.ae

DOI
10.1097/01.tp.0001067024.19971.ae
Journal article

Fibrinogen binding to histones in circulation protects against adverse cellular and clinical outcomes.

Toh, J. M., Yong, J., Abrams, S. T., Wang, L., Schofield, J., Lane, S., . . . Toh, C. -H. (2024). Fibrinogen binding to histones in circulation protects against adverse cellular and clinical outcomes.. Journal of thrombosis and haemostasis : JTH, 22(8), 2247-2260. doi:10.1016/j.jtha.2024.05.009

DOI
10.1016/j.jtha.2024.05.009
Journal article

Restoring discarded porcine lungs by ex vivo removal of neutrophil extracellular traps.

Mittendorfer, M., Pierre, L., Huzevka, T., Schofield, J., Abrams, S. T., Wang, G., . . . Lindstedt, S. (2024). Restoring discarded porcine lungs by ex vivo removal of neutrophil extracellular traps.. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, S1053-2498(24)01736-4. doi:10.1016/j.healun.2024.07.007

DOI
10.1016/j.healun.2024.07.007
Journal article

Wider use of tranexamic acid to reduce surgical bleeding could benefit patients and health systems.

Roberts, I., Murphy, M. F., Moonesinghe, R., Grocott, M. P. W., Kalumbi, C., Sayers, R., . . . UK Royal Colleges Tranexamic Acid in Surgery Implementation Group. (2024). Wider use of tranexamic acid to reduce surgical bleeding could benefit patients and health systems.. BMJ (Clinical research ed.), 385, e079444. doi:10.1136/bmj-2024-079444

DOI
10.1136/bmj-2024-079444
Journal article

Infected Blood Inquiry details failure after failure.

Toh, C. -H., & Buggins, E. (2024). Infected Blood Inquiry details failure after failure.. BMJ (Clinical research ed.), 385, q1220. doi:10.1136/bmj.q1220

DOI
10.1136/bmj.q1220
Journal article

Are NETs a Novel, Exciting, Thrombosis Risk Marker?

Wang, G., Abrams, S. T., & Toh, C. -H. (2024). Are NETs a Novel, Exciting, Thrombosis Risk Marker?. Thrombosis and haemostasis, 124(5), 455-458. doi:10.1055/a-2187-0645

DOI
10.1055/a-2187-0645
Journal article

Alternative routes into clinical research: a guide for early career doctors.

Nicolson, P. L., Belete, M., Hawes, R., Fowler, N., & Toh, C. H. (2024). Alternative routes into clinical research: a guide for early career doctors.. BMJ (Clinical research ed.), 385, e076414. doi:10.1136/bmj-2023-076414

DOI
10.1136/bmj-2023-076414
Journal article

Shades of Grey-The brain in TTP.

Dutt, T., & Toh, C. -H. (2024). Shades of Grey-The brain in TTP.. British journal of haematology, 204(3), 757-758. doi:10.1111/bjh.19293

DOI
10.1111/bjh.19293
Journal article

Trauma-induced innate immune activation and disseminated intravascular coagulation.

Gando, S., Levi, M., & Toh, C. -H. (2024). Trauma-induced innate immune activation and disseminated intravascular coagulation.. Journal of thrombosis and haemostasis : JTH, 22(2), 337-351. doi:10.1016/j.jtha.2023.09.028

DOI
10.1016/j.jtha.2023.09.028
Journal article

2023

Rethinking coagulation: from enzymatic cascade and cell-based reactions to a convergent model involving innate immune activation.

Yong, J., & Toh, C. -H. (2023). Rethinking coagulation: from enzymatic cascade and cell-based reactions to a convergent model involving innate immune activation.. Blood, 142(25), 2133-2145. doi:10.1182/blood.2023021166

DOI
10.1182/blood.2023021166
Journal article

Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia.

Abrams, S. T., Du, M., Shaw, R. J., Johnson, C., McGuinness, D., Schofield, J., . . . Toh, C. -H. (2023). Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia.. Journal of thrombosis and haemostasis : JTH, S1538-7836(23)00873-5. doi:10.1016/j.jtha.2023.12.008

DOI
10.1016/j.jtha.2023.12.008
Journal article

How can we ensure that the right patient gets the right blood at the right time?

Toh, C. -H. (2023). How can we ensure that the right patient gets the right blood at the right time?. BMJ (Clinical research ed.), 383, 2446. doi:10.1136/bmj.p2446

DOI
10.1136/bmj.p2446
Journal article

OC 78.5 Systemic Snakebite Envenoming Causes Histone-Induced Thrombocytopaenia

Schofield, J., Abrams, S., Alhamdi, Y., Ainsworth, S., Evans, C., Albulescu, L., . . . Toh, C. (2023). OC 78.5 Systemic Snakebite Envenoming Causes Histone-Induced Thrombocytopaenia. Research and Practice in Thrombosis and Haemostasis, 7, 100487. doi:10.1016/j.rpth.2023.100487

DOI
10.1016/j.rpth.2023.100487
Journal article

PB0794 Fibrinogen Protects against Histone-Induced Thrombocytopaenia

Yong, J., Abrams, S., Alhamdi, Y., Wang, G., & Toh, C. (2023). PB0794 Fibrinogen Protects against Histone-Induced Thrombocytopaenia. Research and Practice in Thrombosis and Haemostasis, 7, 101370. doi:10.1016/j.rpth.2023.101370

DOI
10.1016/j.rpth.2023.101370
Journal article

How to approach acute thrombosis and thrombocytopenia.

Schofield, J., & Toh, C. -H. (2023). How to approach acute thrombosis and thrombocytopenia.. Clinical medicine (London, England), 23(3), 234-241. doi:10.7861/clinmed2023-0076

DOI
10.7861/clinmed2023-0076
Journal article

Neutrophil Extracellular Traps Removal During Ex Vivo Lung Perfusion Improves Lung Function in Aspiration Damaged Porcine Lungs

Mittendorfer, M., Pierre, L., Kjellberg, G., Schofield, J., Abrams, S., Wang, G., . . . Lindstedt, S. (2023). Neutrophil Extracellular Traps Removal During Ex Vivo Lung Perfusion Improves Lung Function in Aspiration Damaged Porcine Lungs. In JOURNAL OF HEART AND LUNG TRANSPLANTATION Vol. 42 (pp. S115). Retrieved from https://www.webofscience.com/

Conference Paper

A "Bundle of Care" to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study

Jorgensen, A. L., Orrell, C., Waitt, C., Toh, C. -H., Sekaggya-Wiltshire, C., Hughes, D. A., . . . Pirmohamed, M. (2023). A "Bundle of Care" to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study. JMIR RESEARCH PROTOCOLS, 12. doi:10.2196/46710

DOI
10.2196/46710
Journal article

A “Bundle of Care” to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study (Preprint)

DOI
10.2196/preprints.46710
Preprint

Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis

Abrams, S. T. T., Alhamdi, Y., Zi, M., Guo, F., Du, M., Wang, G., . . . Toh, C. -H. (2023). Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(4). doi:10.3390/ijms24043225

DOI
10.3390/ijms24043225
Journal article

Alan Randolph Giles, MD (1940-2022): dogged pioneer and esteemed hematologist

Senis, Y. A., Toh, C. -H., & Lillicrap, D. (2023). Alan Randolph Giles, MD (1940-2022): dogged pioneer and esteemed hematologist. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 21(2), 397-399. doi:10.1016/j.jtha.2022.10.026

DOI
10.1016/j.jtha.2022.10.026
Journal article

Tranexamic acid for safer surgery: does the evidence support preventative use? Response to <i>Br J Anaesth</i> 2023; 130: e23-e24

Grocott, M. P. W., Murphy, M., Roberts, I., Sayers, R., & Toh, C. -H. (2023). Tranexamic acid for safer surgery: does the evidence support preventative use? Response to <i>Br J Anaesth</i> 2023; 130: e23-e24. BRITISH JOURNAL OF ANAESTHESIA, 130(2), E195-E196. doi:10.1016/j.bja.2022.11.010

DOI
10.1016/j.bja.2022.11.010
Journal article

2022

Tranexamic acid for safer surgery: the time is now

Grocott, M. P. W., Murphy, M., Roberts, I., Sayers, R., & Toh, C. -H. (2022). Tranexamic acid for safer surgery: the time is now. BRITISH JOURNAL OF ANAESTHESIA, 129(4), 459-461. doi:10.1016/j.bja.2022.06.024

DOI
10.1016/j.bja.2022.06.024
Journal article

HaemSTAR-Growing Experience From a National, Trainee-led Research Network

Wilson, L., Doyle, A. J., Millen, E., Bull, T., Biss, T., Hart, D., . . . Nicolson, P. L. R. (2022). HaemSTAR-Growing Experience From a National, Trainee-led Research Network. HEMASPHERE, 6(9). doi:10.1097/HS9.0000000000000766

DOI
10.1097/HS9.0000000000000766
Journal article

The Health and Care Act 2022: challenges and priorities for embedding research in the NHS

Toh, C. H., & Haynes, R. (2022). The Health and Care Act 2022: challenges and priorities for embedding research in the NHS. LANCET, 400(10349), 343-345. doi:10.1016/S0140-6736(22)01195-3

DOI
10.1016/S0140-6736(22)01195-3
Journal article

The aetiopathogenesis of vaccine-induced immune thrombotic thrombocytopenia

Toh, C. -H., Wang, G., & Parker, A. L. (2022). The aetiopathogenesis of vaccine-induced immune thrombotic thrombocytopenia. CLINICAL MEDICINE, 22(2), 140-144. doi:10.7861/clinmed.2022-0006

DOI
10.7861/clinmed.2022-0006
Journal article

Rare missense variants in Tropomyosin-4 (TPM4) are associated with platelet dysfunction, cytoskeletal defects, and excessive bleeding.

Stapley, R. J., Poulter, N. S., Khan, A. O., Smith, C. W., Bignell, P., Fratter, C., . . . UK GAPP Study Group. (2022). Rare missense variants in Tropomyosin-4 (TPM4) are associated with platelet dysfunction, cytoskeletal defects, and excessive bleeding.. Journal of thrombosis and haemostasis : JTH, 20(2), 478-485. doi:10.1111/jth.15584

DOI
10.1111/jth.15584
Journal article

A single 1 g/kg dose of intravenous immunoglobulin is a safe and effective treatment for immune thrombocytopenia; results of the first HaemSTAR 'Flash-Mob' retrospective study incorporating 961 patients

Nicolson, P. L. R., Perry, R., Buka, R. J., Fisher, A., Scott, G., Magill, L., . . . Hill, Q. A. (2022). A single 1 g/kg dose of intravenous immunoglobulin is a safe and effective treatment for immune thrombocytopenia; results of the first HaemSTAR 'Flash-Mob' retrospective study incorporating 961 patients. BRITISH JOURNAL OF HAEMATOLOGY, 196(2), 433-437. doi:10.1111/bjh.17692

DOI
10.1111/bjh.17692
Journal article

2021

Transfusion 2024: A 5-year plan for clinical and laboratory transfusion in England

Allard, S., Cort, J., Howell, C., Sherliker, L., Miflin, G., & Toh, C. H. (2021). Transfusion 2024: A 5-year plan for clinical and laboratory transfusion in England. TRANSFUSION MEDICINE, 31(6), 400-408. doi:10.1111/tme.12827

DOI
10.1111/tme.12827
Journal article

The art and science of the thrombosis with thrombocytopenia syndrome

Toh, C. -H. (2021). The art and science of the thrombosis with thrombocytopenia syndrome. CLINICAL MEDICINE, 21(6), E603. doi:10.7861/clinmed.2021-0525

DOI
10.7861/clinmed.2021-0525
Journal article

Intracranial hemorrhage in immune thrombotic thrombocytopenic purpura treated with caplacizumab

Schofield, J., Shaw, R. J., Lester, W., Thomas, W., Toh, C. -H., & Dutt, T. (2021). Intracranial hemorrhage in immune thrombotic thrombocytopenic purpura treated with caplacizumab. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 19(8), 1922-1925. doi:10.1111/jth.15363

DOI
10.1111/jth.15363
Journal article

Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation

Abrams, S. T., Su, D., Sahraoui, Y., Lin, Z., Cheng, Z., Nesbitt, K., . . . Toh, C. -H. (2021). Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation. BLOOD, 137(1), 103-114. doi:10.1182/blood.2019002973

DOI
10.1182/blood.2019002973
Journal article

ADAMTS13 activity trends in TTP patients with COVID-19 infection

Shaw, R. J., Kenworthy, J., Lawrenson, A., Toh, C. -H., & Dutt, T. (2021). ADAMTS13 activity trends in TTP patients with COVID-19 infection. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 193 (pp. 211). Retrieved from https://www.webofscience.com/

Conference Paper

OPTIMISATION OF ORAL ANTICOAGULATION FOR STROKE PREVENTION: A SCOPING REVIEW OF FACTORS INFLUENCING UPTAKE AND IMPLEMENTATION IN EFFECTIVENESS STUDIES

Gibson, J., Weldon, J., Banerjee, A., Chauhan, U., Georgiou, R., Joshi, M., . . . Watkins, C. (2021). OPTIMISATION OF ORAL ANTICOAGULATION FOR STROKE PREVENTION: A SCOPING REVIEW OF FACTORS INFLUENCING UPTAKE AND IMPLEMENTATION IN EFFECTIVENESS STUDIES. In INTERNATIONAL JOURNAL OF STROKE Vol. 16 (pp. 37). Retrieved from https://www.webofscience.com/

Conference Paper

2020

Extracellular histones stimulate collagen expression <i>in vitro</i> and promote liver fibrogenesis in a mouse model <i>via </i>the TLR4-MyD88 signaling pathway

Wang, Z., Cheng, Z. -X., Abrams, S. T., Lin, Z. -Q., Yates, E. D., Yu, Q., . . . Wang, G. -Z. (2020). Extracellular histones stimulate collagen expression <i>in vitro</i> and promote liver fibrogenesis in a mouse model <i>via </i>the TLR4-MyD88 signaling pathway. WORLD JOURNAL OF GASTROENTEROLOGY, 26(47), 7513-7527. doi:10.3748/wjg.v26.i47.7513

DOI
10.3748/wjg.v26.i47.7513
Journal article

Circulating Histone Levels Correlate with the Severity of COVID-19 and the Extent of Coagulation Activation and Inflammation

Shaw, R. J., Austin, J., Taylor, J., Dutt, T., Wang, G., Abrams, S. T., & Toh, C. H. (2020). Circulating Histone Levels Correlate with the Severity of COVID-19 and the Extent of Coagulation Activation and Inflammation. In BLOOD Vol. 136. doi:10.1182/blood-2020-142344

DOI
10.1182/blood-2020-142344
Conference Paper

Extracellular histones stimulate collagen expression and potentially promote liver fibrogenesis via TLR4-MyD88 signalling pathway

DOI
10.1101/2020.09.17.302240
Preprint

The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development

Cheng, Z., Abrams, S. T., Austin, J., Toh, J., Wang, S. S., Wang, Z., . . . Wang, G. (2020). The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development. MEDIATORS OF INFLAMMATION, 2020. doi:10.1155/2020/7418342

DOI
10.1155/2020/7418342
Journal article

Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort.

Thaventhiran, J. E. D., Lango Allen, H., Burren, O. S., Rae, W., Greene, D., Staples, E., . . . Smith, K. G. C. (2020). Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort.. Nature, 584(7819), E2. doi:10.1038/s41586-020-2556-6

DOI
10.1038/s41586-020-2556-6
Journal article

Cancer associated thrombosis in everyday practice: perspectives from GARFIELD-VTE.

Weitz, J. I., Haas, S., Ageno, W., Goldhaber, S. Z., Turpie, A. G. G., Goto, S., . . . GARFIELD-VTE investigators. (2020). Cancer associated thrombosis in everyday practice: perspectives from GARFIELD-VTE.. Journal of thrombosis and thrombolysis, 50(2), 267-277. doi:10.1007/s11239-020-02180-x

DOI
10.1007/s11239-020-02180-x
Journal article

Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria

Moxon, C. A., Alhamdi, Y., Storm, J., Toh, J. M. H., McGuinness, D., Ko, J. Y., . . . Toh, C. (n.d.). Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria. Blood Advances, 4(13), 2851-2864. doi:10.1182/bloodadvances.2019001258

DOI
10.1182/bloodadvances.2019001258
Journal article

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Thaventhiran, J. E. D., Allen, H. L., Burren, O. S., Rae, W., Greene, D., Staples, E., . . . Smith, K. G. C. (2020). Whole-genome sequencing of a sporadic primary immunodeficiency cohort. NATURE, 583(7814), 90-+. doi:10.1038/s41586-020-2265-1

DOI
10.1038/s41586-020-2265-1
Journal article

Whole-genome sequencing of patients with rare diseases in a national health system

Turro, E., Astle, W. J., Megy, K., Graef, S., Greene, D., Shamardina, O., . . . Ouwehand, W. H. (2020). Whole-genome sequencing of patients with rare diseases in a national health system. NATURE, 583(7814), 96-+. doi:10.1038/s41586-020-2434-2

DOI
10.1038/s41586-020-2434-2
Journal article

Blood works

Toh, C. -H., & Amberley, K. (2020). Blood works. BRITISH JOURNAL OF HAEMATOLOGY, 189(3), 391-392. doi:10.1111/bjh.16650

DOI
10.1111/bjh.16650
Journal article

A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit.

Abrams, S., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2020). A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit.. Clinical medicine (London, England), 20(Suppl 2), s114-s115. doi:10.7861/clinmed.20-2-s114

DOI
10.7861/clinmed.20-2-s114
Journal article

A novel assay of neutrophil extracellular traps (NETs) formation independently predicts DIC and identifies the rationale for anti-IL-8 therapies

Abrams, S., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2020). A novel assay of neutrophil extracellular traps (NETs) formation independently predicts DIC and identifies the rationale for anti-IL-8 therapies. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 189 (pp. 42). Retrieved from https://www.webofscience.com/

Conference Paper

Patients with acute thrombotic thrombocytopenic purpura (TTP) should be managed in a critical care setting - A Single TTP Referral Centre Experience

Shaw, R. J., Garth, L., Toh, C. -H., & Dutt, T. (2020). Patients with acute thrombotic thrombocytopenic purpura (TTP) should be managed in a critical care setting - A Single TTP Referral Centre Experience. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 189 (pp. 268). Retrieved from https://www.webofscience.com/

Conference Paper

2019

Enabling an equitable spread of research access, involvement, and funding in the UK

Toh, C. -H. (2019). Enabling an equitable spread of research access, involvement, and funding in the UK. LANCET, 394(10214), 2048-2050. Retrieved from https://www.webofscience.com/

Journal article

A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies

Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2019). A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies. In BLOOD Vol. 134. Retrieved from https://www.webofscience.com/

Conference Paper

A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients

Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M., Lane, S., Welters, I. D., . . . Toh, C. -H. (2019). A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients. American journal of respiratory and critical care medicine, 200(07), 869-880. doi:10.1164/rccm.201811-2111oc

DOI
10.1164/rccm.201811-2111oc
Journal article

Disseminated intravascular coagulation - what can we do?

Toh, C. -H., Toh, J. M. H., & Abrams, S. T. (2019). Disseminated intravascular coagulation - what can we do?. HEMASPHERE, 3, 92-94. doi:10.1097/HS9.0000000000000232

DOI
10.1097/HS9.0000000000000232
Journal article

Germline selection shapes human mitochondrial DNA diversity

Wei, W., Tuna, S., Keogh, M. J., Smith, K. R., Aitman, T. J., Beales, P. L., . . . Chinnery, P. F. (2019). Germline selection shapes human mitochondrial DNA diversity. SCIENCE, 364(6442), 749-+. doi:10.1126/science.aau6520

DOI
10.1126/science.aau6520
Journal article

Developing today's trainees to become tomorrow's clinical researchers - an innovative collaboration driving improvements in clinical training and research delivery.

Loizou, E., Karpha, I., Toh, C. -H., & Dutt, T. (2019). Developing today's trainees to become tomorrow's clinical researchers - an innovative collaboration driving improvements in clinical training and research delivery.. Future healthcare journal, 6(Suppl 1), 112. doi:10.7861/futurehosp.6-1-s112

DOI
10.7861/futurehosp.6-1-s112
Journal article

Parasite histones mediate leak and coagulopathy in cerebral malaria

DOI
10.1101/563551
Preprint

Characteristics and Management of Patients with Venous Thromboembolism: The GARFIELD-VTE Registry

Ageno, W., Haas, S., Weitz, J. I., Goldhaber, S. Z., Turpie, A. G. G., Goto, S., . . . Yang, Z. (2019). Characteristics and Management of Patients with Venous Thromboembolism: The GARFIELD-VTE Registry. THROMBOSIS AND HAEMOSTASIS, 119(2), 319-327. doi:10.1055/s-0038-1676611

DOI
10.1055/s-0038-1676611
Journal article

A HaemSTAR is born; a trainee-led, UK-wide research network in haematology

Nicolson, P. L. R., Desborough, M. J. R., Hart, D., Biss, T. T., Lowe, G. C., & Toh, C. -H. (2019). A HaemSTAR is born; a trainee-led, UK-wide research network in haematology. CLINICAL MEDICINE, 19(6), 532-533. doi:10.7861/clinmed.2019-0313

DOI
10.7861/clinmed.2019-0313
Journal article

DIAPH1-related disorder: audiological phenotype and comparison to MYH9-related disorder and Takenouchi-Kosaki syndrome

Westbury, S., Burney, C., Obaji, S., Collins, P., Toh, C. -H., & Mumford, A. (2019). DIAPH1-related disorder: audiological phenotype and comparison to MYH9-related disorder and Takenouchi-Kosaki syndrome. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 185 (pp. 134-135). Retrieved from https://www.webofscience.com/

Conference Paper

Parasite histones are associated with poor outcome in cerebral malaria

Moxon, C., Alhamdi, Y., Storm, J., Toh, J., Ko, J. Y., Murphy, G., . . . Toh, C. -H. (2019). Parasite histones are associated with poor outcome in cerebral malaria. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 185 (pp. 33). Retrieved from https://www.webofscience.com/

Conference Paper

2018

Histones Bind Prothrombin to Generate Alternative Prothrombinase Complexes That Can Disseminate Intravascular Coagulation

Abrams, S. T., Su, D., Sahraoui, Y., Alhamdi, Y., Wang, G., & Toh, C. H. (2018). Histones Bind Prothrombin to Generate Alternative Prothrombinase Complexes That Can Disseminate Intravascular Coagulation. In BLOOD Vol. 132. doi:10.1182/blood-2018-99-116117

DOI
10.1182/blood-2018-99-116117
Conference Paper

Phenotype description and response to thrombopoietin receptor agonist in <i>DIAPH1</i>-related disorder

Westbury, S. K., Downes, K., Burney, C., Lozano, M. L., Obaji, S. G., Toh, C. H., . . . Mumford, A. D. (2018). Phenotype description and response to thrombopoietin receptor agonist in <i>DIAPH1</i>-related disorder. BLOOD ADVANCES, 2(18), 2341-2346. doi:10.1182/bloodadvances.2018020370

DOI
10.1182/bloodadvances.2018020370
Journal article

A re-evaluation of the D-dimer cut-off value for making a diagnosis according to the ISTH overt-DIC diagnostic criteria: communication from the SSC of the ISTH

Suzuki, K., Wada, H., Imai, H., Iba, T., Thachil, J., & Toh, C. -H. (2018). A re-evaluation of the D-dimer cut-off value for making a diagnosis according to the ISTH overt-DIC diagnostic criteria: communication from the SSC of the ISTH. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 16(7), 1442-1444. doi:10.1111/jth.14134

DOI
10.1111/jth.14134
Journal article

Circulating histones are major mediators of cardiac complications in sepsis

Wang, G., Alhamdi, Y., Abrams, S. T., & Toh, C. H. (2018). Circulating histones are major mediators of cardiac complications in sepsis. In CARDIOVASCULAR RESEARCH Vol. 114 (pp. S99). doi:10.1093/cvr/cvy060.294

DOI
10.1093/cvr/cvy060.294
Conference Paper

Case report: A successful pregnancy in Haemophillia A

Yong, J., & Toh, C. -H. (2018). Case report: A successful pregnancy in Haemophillia A. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 181 (pp. 205). Retrieved from https://www.webofscience.com/

Conference Paper

Case report: a successful pregnancy in hemophilia A

Yong, J., & Toh, C. -H. (2018). Case report: a successful pregnancy in hemophilia A. In HAEMOPHILIA Vol. 24 (pp. 94). Retrieved from https://www.webofscience.com/

Conference Paper

Haematology Speciality Trainees Driving NIHR Clinical Research: The North-West Coast Clinical Research Network (NWC CRN) Experience

Loizou, E., Karpha, I., Nicholson, T., Toh, C. -H., & Dutt, T. (2018). Haematology Speciality Trainees Driving NIHR Clinical Research: The North-West Coast Clinical Research Network (NWC CRN) Experience. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 181 (pp. 168). Retrieved from https://www.webofscience.com/

Conference Paper

Neutrophil Extracellular Traps (NETs) formation in Patients newly diagnosed with Myeloma: Findings from the Thromboprophylaxis in Multiple Myeloma (TiMM) Study

Sayar, Z., Abrams, S. T., Alsabani, M., Czuprynska, J., Benjamin, R., Patel, J. P., . . . Toh, C. H. (2018). Neutrophil Extracellular Traps (NETs) formation in Patients newly diagnosed with Myeloma: Findings from the Thromboprophylaxis in Multiple Myeloma (TiMM) Study. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 181 (pp. 140-141). Retrieved from https://www.webofscience.com/

Conference Paper

2017

Phenotypic Characterization of <i>EIF2AK4</i> Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension.

Hadinnapola, C., Bleda, M., Haimel, M., Screaton, N., Swift, A., Dorfmüller, P., . . . Morrell, N. W. (2017). Phenotypic Characterization of <i>EIF2AK4</i> Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension.. Circulation, 136(21), 2022-2033. doi:10.1161/circulationaha.117.028351

DOI
10.1161/circulationaha.117.028351
Journal article

Extracellular histones inhibit complement activation through interactions with complement component C4b

Qaddoori, Y., Abrams, S. T., Su, D., Liu, T., Alhamdi, Y., Wang, G., & Toh, C. -H. (2017). Extracellular histones inhibit complement activation through interactions with complement component C4b. In MOLECULAR IMMUNOLOGY Vol. 89 (pp. 132). doi:10.1016/j.molimm.2017.06.067

DOI
10.1016/j.molimm.2017.06.067
Conference Paper

Circulating histones associate with severity and play important roles in acute pancreatitis

Lin, Z., Cheng, Z., Liu, T., Wang, G., Sutton, R., & Toh, C. -H. (2017). Circulating histones associate with severity and play important roles in acute pancreatitis. Pancreatology, 17(3), S33. doi:10.1016/j.pan.2017.05.102

DOI
10.1016/j.pan.2017.05.102
Journal article

143 The roles and mechanisms of pore-forming toxins in cardiac injury

Wang, G., Alhamdi, Y., & Toh, C. -H. (2017). 143 The roles and mechanisms of pore-forming toxins in cardiac injury. Heart, 103(Suppl 5), A107.1-A107. doi:10.1136/heartjnl-2017-311726.142

DOI
10.1136/heartjnl-2017-311726.142
Journal article

Elevated Circulating Histones Associate With Multiple Organ Dysfunction Syndromes in Acute Pancreatitis

Liu, T., Huang, W., Abrams, S., Wang, L., Szatmary, P., Alhamdi, Y., . . . Sutton, R. (2016). Elevated Circulating Histones Associate With Multiple Organ Dysfunction Syndromes in Acute Pancreatitis. PANCREAS, 45(10), 1520. Retrieved from https://www.webofscience.com/

Journal article

Biallelic Mutation of <i>ARHGEF18</i>, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration

Arno, G., Carss, K. J., Hull, S., Zihni, C., Robson, A. G., Fiorentino, A., . . . Webster, A. R. (2017). Biallelic Mutation of <i>ARHGEF18</i>, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration. AMERICAN JOURNAL OF HUMAN GENETICS, 100(2), 334-342. doi:10.1016/j.ajhg.2016.12.014

DOI
10.1016/j.ajhg.2016.12.014
Journal article

Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation (vol 36, pg 505, 2016)

Toh, C. -H., Alhamdi, Y., & Abrams, S. T. (2017). Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation (vol 36, pg 505, 2016). ANNALS OF LABORATORY MEDICINE, 37(1), 95. doi:10.3343/alm.2017.37.1.95

DOI
10.3343/alm.2017.37.1.95
Journal article

THE ROLES AND MECHANISMS OF PORE-FORMING TOXINS IN CARDIAC INJURY

Wang, G., Alhamdi, Y., & Toh, C. -H. (2017). THE ROLES AND MECHANISMS OF PORE-FORMING TOXINS IN CARDIAC INJURY. In HEART Vol. 103 (pp. A107). Retrieved from https://www.webofscience.com/

Conference Paper

2016

Disseminated intravascular coagulation

Gando, S., Levi, M., & Toh, C. -H. (2016). Disseminated intravascular coagulation. In Unknown Book (Vol. 2). doi:10.1038/nrdp.2016.37

DOI
10.1038/nrdp.2016.37
Chapter

Disseminated intravascular coagulation.

Gando, S., Levi, M., & Toh, C. -H. (2016). Disseminated intravascular coagulation.. Nature reviews. Disease primers, 2, 16037. doi:10.1038/nrdp.2016.37

DOI
10.1038/nrdp.2016.37
Journal article

Circulating histones accurately predict persistent organ failure and mortality in patients with acute pancreatitis within 24 h of admission

Liu, T., Huang, W., Szatmary, P., Abrams, S., Alhamdi, Y., Lin, Z., . . . Toh, C. -H. (2016). Circulating histones accurately predict persistent organ failure and mortality in patients with acute pancreatitis within 24 h of admission. Pancreatology, 16(3), S100-S101. doi:10.1016/j.pan.2016.05.338

DOI
10.1016/j.pan.2016.05.338
Journal article

Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding (vol 13, pg 1653, 2015)

Moxon, C. A., Chisala, N. V., Mzikamanda, R., MacCormick, I., Harding, S., Downey, C., . . . Toh, C. H. (2016). Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding (vol 13, pg 1653, 2015). JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 14(2), 415. doi:10.1111/jth.13233

DOI
10.1111/jth.13233
Journal article

EXTRACELLULAR HISTONES ENHANCE FACTOR XA MEDIATED PROTHROMBIN ACTIVATION WITHOUT PHOSPHOLIPID REQUIREMENT

Sahraoui, Y., Abrams, S., Su, D., Alhamdi, Y., Foley, J., Wang, G., & Toh, C. H. (2016). EXTRACELLULAR HISTONES ENHANCE FACTOR XA MEDIATED PROTHROMBIN ACTIVATION WITHOUT PHOSPHOLIPID REQUIREMENT. In HAEMATOLOGICA Vol. 101 (pp. 310). Retrieved from https://www.webofscience.com/

Conference Paper

Early prediction of major clinical outcomes of patients with acute pancreatitis by circulating histones

Liu, T., Huang, W., Szatmary, P., Abrams, S. T., Greenhalf, W., Welters, I., . . . Toh, C. H. (2016). Early prediction of major clinical outcomes of patients with acute pancreatitis by circulating histones. Pancreatology, 16(1), S34. doi:10.1016/j.pan.2015.12.107

DOI
10.1016/j.pan.2015.12.107
Journal article

Extracellular histones promote prothrombin activation in the absence of phospholipids

Sahraoui, Y., Abrams, S. T., Su, D., Alhamdi, Y., Foley, J., Wang, G., & Toh, C. H. (2016). Extracellular histones promote prothrombin activation in the absence of phospholipids. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 173 (pp. 19). Retrieved from https://www.webofscience.com/

Conference Paper

Histone-associated thrombocytopaenia is a significant cause of thrombocytopaenia in critical illness

Alhamdi, Y., Abrams, S. T., Lane, S., Wang, G., & Toh, C. H. (2016). Histone-associated thrombocytopaenia is a significant cause of thrombocytopaenia in critical illness. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 173 (pp. 19). Retrieved from https://www.webofscience.com/

Conference Paper

2015

Acquired coagulation disorders

Collins, P. W., Thachil, J., & Toh, C. -H. (2016). Acquired coagulation disorders. In POSTGRADUATE HAEMATOLOGY, 7TH EDITION (pp. 743-760). Retrieved from https://www.webofscience.com/

Chapter

Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis

Ou, X., Cheng, Z., Liu, T., Tang, Z., Huang, W., Szatmary, P., . . . Wang, G. (2015). Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis. Pancreas, 44(7), 1089-1095. doi:10.1097/MPA.0000000000000416

DOI
10.1097/MPA.0000000000000416
Journal article

Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding

Moxon, C. A., Chisala, N. V., Mzikamanda, R., MacCormick, I., Harding, S., Downey, C., . . . Toh, C. -H. (2015). Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13(9), 1653-1664. doi:10.1111/jth.13060

DOI
10.1111/jth.13060
Journal article

Circulating histones contribute to acute respiratory distress syndrome in acute pancreatitis

Liu, T., Abrams, S., Szatmary, P., Cheng, Z., Huang, W., Ou, X., . . . Toh, C. -H. (2015). Circulating histones contribute to acute respiratory distress syndrome in acute pancreatitis. Pancreatology, 15(3), S63. doi:10.1016/j.pan.2015.05.242

DOI
10.1016/j.pan.2015.05.242
Journal article

Thrombotic thrombocytopenic purpura specialist centres: providing better outcomes for patients with rare but life-threatening conditions.

Dutt, T., Martlew, V., Toh, C. H., & Jones, C. K. (2015). Thrombotic thrombocytopenic purpura specialist centres: providing better outcomes for patients with rare but life-threatening conditions.. Clinical medicine (London, England), 15 Suppl 3, s21. doi:10.7861/clinmedicine.15-3-s21

DOI
10.7861/clinmedicine.15-3-s21
Journal article

Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis

Ou, X., Cheng, Z., Liu, T., Tang, Z., Huang, W., Szatmary, P., . . . Wang, G. (2015). Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis.

Journal article

Circulating Histones Target Acinar Cells and Exacerbate Injury in Experimental Acute Pancreatitis

Szatmary, P., Liu, T., Abrams, S., Wen, L., Huang, W., Wang, G., . . . Sutton, R. (2015). Circulating Histones Target Acinar Cells and Exacerbate Injury in Experimental Acute Pancreatitis. PANCREAS, 44(8), 1418. Retrieved from https://www.webofscience.com/

Journal article

Early Prediction of Major Clinical Outcomes of Patients With Acute Pancreatitis by Circulating Histones

Liu, T., Huang, W., Szatmary, P., Abrams, S. T., Greenhalf, W., Welters, I., . . . Toh, C. H. (2015). Early Prediction of Major Clinical Outcomes of Patients With Acute Pancreatitis by Circulating Histones. PANCREAS, 44(8), 1393. Retrieved from https://www.webofscience.com/

Journal article

Exploring the psychosocial implications of living and coping with sickle cell crisis: an interpretative phenomenological analysis

Barrow, E., Houghton, A., Simcox, D., & Toh, C. H. (2015). Exploring the psychosocial implications of living and coping with sickle cell crisis: an interpretative phenomenological analysis. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 169 (pp. 103-104). Retrieved from https://www.webofscience.com/

Conference Paper

Histone-associated thrombocytopenia: a new cause of thrombocytopenia in critically ill patients

Alhamdi, Y., Abrams, S. T., Welters, I., Wang, G., & Toh, C. -H. (2015). Histone-associated thrombocytopenia: a new cause of thrombocytopenia in critically ill patients. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13, 94. Retrieved from https://www.webofscience.com/

Journal article

Neuro-imaging does not correlate with disease severity in acute thrombotic thrombocytopenia purpura (TTP), but may predict long term sequelae

Karpha, I., Kay-Jones, C., Burgiss, J., Martlew, V., Toh, C. H., Fitzsimmons, P., & Dutt, T. (2015). Neuro-imaging does not correlate with disease severity in acute thrombotic thrombocytopenia purpura (TTP), but may predict long term sequelae. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13, 470. Retrieved from https://www.webofscience.com/

Journal article

Patients with suspected TTP should be acutely managed in a critical care setting

Burgess, J. L., Jones, C. K., Karpha, I., Martlew, V. J., Toh, C. H., & Dutt, T. (2015). Patients with suspected TTP should be acutely managed in a critical care setting. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 169 (pp. 45). Retrieved from https://www.webofscience.com/

Conference Paper

Short and long term neurological complications of thrombotic thrombocytopenic purpura (TTP)

Karpha, I., Kay-Jones, C., Burgiss, J., Martlew, V. J., Toh, C. H., Fitzsimmons, P., & Dutt, T. (2015). Short and long term neurological complications of thrombotic thrombocytopenic purpura (TTP). In BRITISH JOURNAL OF HAEMATOLOGY Vol. 169 (pp. 48). Retrieved from https://www.webofscience.com/

Conference Paper

2014

Protective Effects of Carbon Monoxide-Releasing Molecule-2 on the Barrier Function of Intestinal Epithelial Cells

Mu, X., Pan, C., Zheng, S., Alhamdi, Y., Sun, B., Shi, Q., . . . Wang, G. (2014). Protective Effects of Carbon Monoxide-Releasing Molecule-2 on the Barrier Function of Intestinal Epithelial Cells. PLOS ONE, 9(8). doi:10.1371/journal.pone.0104032

DOI
10.1371/journal.pone.0104032
Journal article

A Master Class for European Hematology

Toh, C. H., Strivens, J., Guenova, M., & Modok, S. (2014). A Master Class for European Hematology. HAEMATOLOGICA, 99(6), 949-951. doi:10.3324/haematol.2014.107540

DOI
10.3324/haematol.2014.107540
Journal article

Survey of professional competence in hematology in Europe

Lindberg, E. H., Almeida, A., Enoksson, F., de Wit, T. D., Strivens, J., Naeve, A., & Toh, C. -H. (2014). Survey of professional competence in hematology in Europe. HAEMATOLOGICA, 99(3), 404-408. doi:10.3324/haematol.2014.104299

DOI
10.3324/haematol.2014.104299
Journal article

Role of sequestration-induced loss of protein C receptors in coagulation and inflammation in cerebral malaria

Moxon, C., Wassmer, S., Milner, D. J., Chisala, N., Taylor, T., Seydel, K., . . . Heyderman, R. (2014). Role of sequestration-induced loss of protein C receptors in coagulation and inflammation in cerebral malaria. In LANCET Vol. 383 (pp. 75). Retrieved from https://www.webofscience.com/

Conference Paper

HYPOMAGNESAEMIA IN CRITICAL CARE

Homer, L. E., Kolammunage-Dona, R., Steele, T., Toh, C. -H., Downey, C., & Welters, I. D. (2014). HYPOMAGNESAEMIA IN CRITICAL CARE. In INTENSIVE CARE MEDICINE Vol. 40 (pp. S196-S197). Retrieved from https://www.webofscience.com/

Conference Paper

LOW SERUM PHOSPHATE LEVELS IN CRITICAL ILLNESS

Agarwal, K., Kolammunage-Dona, R., Steele, T., Toh, C. H., Downey, C., & Welters, I. D. (2014). LOW SERUM PHOSPHATE LEVELS IN CRITICAL ILLNESS. In INTENSIVE CARE MEDICINE Vol. 40 (pp. S178). Retrieved from https://www.webofscience.com/

Conference Paper

SEVERE HYPONATRAEMIA IN CRITICAL ILLNESS

Lee, S. D., Gilmartin, M., Nee, A., Steele, T., Toh, C. H., & Welters, I. (2014). SEVERE HYPONATRAEMIA IN CRITICAL ILLNESS. In INTENSIVE CARE MEDICINE Vol. 40 (pp. S196). Retrieved from https://www.webofscience.com/

Conference Paper

Safe implementation of the new oral anticoagulants (NOACs) requires patient monitoring

Loizou, E., Toh, C. -H., & Dutt, T. (2014). Safe implementation of the new oral anticoagulants (NOACs) requires patient monitoring. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 12, 9. Retrieved from https://www.webofscience.com/

Journal article

The Role of Neutrophil Extracellular Traps in Acute Pancreatitis

Szatmary, P., Liu, T., Wen, L., Huang, W., Awais, M., Wang, G., . . . Sutton, R. (2014). The Role of Neutrophil Extracellular Traps in Acute Pancreatitis. PANCREAS, 43(8), 1413. Retrieved from https://www.webofscience.com/

Journal article

Use of Citrullinated Histones and Circulating Nucleosomes in Early Prediction of Organ Failure in Acute Pancreatitis

Szatmary, P., Liu, T., Huang, W., Wang, G., Latawiec, D., Davies, K., . . . Sutton, R. (2014). Use of Citrullinated Histones and Circulating Nucleosomes in Early Prediction of Organ Failure in Acute Pancreatitis. PANCREAS, 43(8), 1413. Retrieved from https://www.webofscience.com/

Journal article

2013

A Randomized Trial of Genotype-Guided Dosing of Warfarin

Pirmohamed, M., Burnside, G., Eriksson, N., Jorgensen, A. L., Toh, C. H., Nicholson, T., . . . Wadelius, M. (2013). A Randomized Trial of Genotype-Guided Dosing of Warfarin. NEW ENGLAND JOURNAL OF MEDICINE, 369(24), 2294-2303. doi:10.1056/NEJMoa1311386

DOI
10.1056/NEJMoa1311386
Journal article

A Randomized Trial of Genotype-Guided Dosing of Warfarin

Pirmohamed, M., Burnside, G., Eriksson, N., Jorgensen, A. L., Toh, C. H., Nicholson, T., . . . Wadelius, M. (2013). A Randomized Trial of Genotype-Guided Dosing of Warfarin. New England Journal of Medicine, 369(24), 2294-2303. doi:10.1056/nejmoa1311386

DOI
10.1056/nejmoa1311386
Journal article

Current consideration and management of disseminated intravascular coagulation.

Toh, C. H., & Alhamdi, Y. (2013). Current consideration and management of disseminated intravascular coagulation.. Hematology. American Society of Hematology. Education Program, 2013, 286-291. doi:10.1182/asheducation-2013.1.286

DOI
10.1182/asheducation-2013.1.286
Journal article

Histone-Induced Lung Injury and Coagulation Activation Are Reduced By C-Reactive Protein In The Acute Phase Response

Abrams, S. T., Zhang, N., Wang, G., & Toh, C. -H. (2013). Histone-Induced Lung Injury and Coagulation Activation Are Reduced By C-Reactive Protein In The Acute Phase Response. In BLOOD Vol. 122. doi:10.1182/blood.V122.21.457.457

DOI
10.1182/blood.V122.21.457.457
Conference Paper

Human CRP Defends against the Toxicity of Circulating Histones

Abrams, S. T., Zhang, N., Dart, C., Wang, S. S., Thachil, J., Guan, Y., . . . Toh, C. -H. (2013). Human CRP Defends against the Toxicity of Circulating Histones. JOURNAL OF IMMUNOLOGY, 191(5), 2495-2502. doi:10.4049/jimmunol.1203181

DOI
10.4049/jimmunol.1203181
Journal article

Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children

Moxon, C. A., Wassmer, S. C., Milner, D. A. J., Chisala, N. V., Taylor, T. E., Seydel, K. B., . . . Heyderman, R. S. (2013). Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children. BLOOD, 122(5), 842-851. doi:10.1182/blood-2013-03-490219

DOI
10.1182/blood-2013-03-490219
Journal article

Assessment and clinical course of hypocalcemia in critical illness

Steele, T., Kolamunnage-Dona, R., Downey, C., Toh, C. -H., & Welters, I. (2013). Assessment and clinical course of hypocalcemia in critical illness. CRITICAL CARE, 17(3). doi:10.1186/cc12756

DOI
10.1186/cc12756
Journal article

Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines.

Wada, H., Thachil, J., Di Nisio, M., Mathew, P., Kurosawa, S., Gando, S., . . . The Scientific Standardization Committee on DIC of the International Society on Thrombosis Haemostasis. (2013). Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines.. Journal of thrombosis and haemostasis : JTH. doi:10.1111/jth.12155

DOI
10.1111/jth.12155
Journal article

A Randomized Trial Comparing Genotype-Guided Dosing of Warfarin to Standard Dosing: The EU Pharmacogenetics of Anticoagulant Therapy (EU-PACT) Warfarin Study

Pirmohamed, M., Burnside, G., Stoddern, J., Prince, C., Toh, C. H., Nicholson, T., . . . Wadelius, M. (2013). A Randomized Trial Comparing Genotype-Guided Dosing of Warfarin to Standard Dosing: The EU Pharmacogenetics of Anticoagulant Therapy (EU-PACT) Warfarin Study. CIRCULATION, 128(24), 2710-2711. Retrieved from https://www.webofscience.com/

Journal article

Activated protein C (APC) and thrombin modulate cardiomyocytes contractility via a protease activated receptor-1 (PAR1)-cardiac troponin I (CTI) pathway

Alhamdi, Y., Wang, G., & Toh, C. -H. (2013). Activated protein C (APC) and thrombin modulate cardiomyocytes contractility via a protease activated receptor-1 (PAR1)-cardiac troponin I (CTI) pathway. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 38). Retrieved from https://www.webofscience.com/

Conference Paper

Acute phase proteins reduce histone-induced platelet aggregation and coagulation activation

Abrams, S. T., Manson, J., Liu, T., Baluwa, F., Barrera, V., Brohi, K., . . . Toh, C. H. (2013). Acute phase proteins reduce histone-induced platelet aggregation and coagulation activation. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 22). Retrieved from https://www.webofscience.com/

Conference Paper

Adherence and variability in warfarin dose requirements: assessment in a prospective cohort

Jorgensen, A. L., Hughes, D. A., Hanson, A., van Eker, D., Toh, C. H., Pirmohamed, M., & Williamson, P. R. (2013). Adherence and variability in warfarin dose requirements: assessment in a prospective cohort. PHARMACOGENOMICS, 14(2), 151-163. doi:10.2217/PGS.12.199

DOI
10.2217/PGS.12.199
Journal article

Circulating histone-induced thrombosis leads to circulatory and respiratory failure

Abrams, S. T., Manson, J., Liu, T., Alhamdi, Y., Brohi, K., Wang, G., & Toh, C. H. (2013). Circulating histone-induced thrombosis leads to circulatory and respiratory failure. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 128). Retrieved from https://www.webofscience.com/

Conference Paper

Improving specificity for diagnosing heparin-induced thrombocytopenia through repeated testing

Vithanarachchi, S., Saminaden, L., Downey, C., Toh, C. H., & Dutt, T. (2013). Improving specificity for diagnosing heparin-induced thrombocytopenia through repeated testing. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 542). Retrieved from https://www.webofscience.com/

Conference Paper

Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children.

Moxon, C. A., Wassmer, S. C., Milner, D. A. J., Chisala, N. V., Taylor, T. E., Seydel, K. B., . . . Heyderman, R. S. (2013). Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children.. Blood, 122(5), 842-845. doi:10.1182/blood-2013-03-490219

DOI
10.1182/blood-2013-03-490219
Journal article

Loss of protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria

Moxon, C. A., Wassmer, S. C., Milner, D. A., Chisala, N. V., Taylor, T. E., Seydel, K. B., . . . Heyderman, R. S. (2013). Loss of protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 4). Retrieved from https://www.webofscience.com/

Conference Paper

Platelet surface high mobility group box protein-1 binds receptor for advanced glycation endproducts in plasma or on monocytes in septic patients

Thachil, J., Barrera, V., Djebabri, B., Abrams, S. T., Wang, G., & Toh, C. H. (2013). Platelet surface high mobility group box protein-1 binds receptor for advanced glycation endproducts in plasma or on monocytes in septic patients. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 71). Retrieved from https://www.webofscience.com/

Conference Paper

2012

Comparison of disseminated intravascular coagulation in trauma with coagulopathy of trauma/acute coagulopathy of trauma-shock.

Gando, S., Wada, H., Kim, H. K., Kurosawa, S., Nielsen, J. D., Thachil, J., . . . Scientific and Standardization Committee on DIC of the ISTH. (2012). Comparison of disseminated intravascular coagulation in trauma with coagulopathy of trauma/acute coagulopathy of trauma-shock.. Journal of thrombosis and haemostasis : JTH, 10(12), 2593-2595. doi:10.1111/jth.12011

DOI
10.1111/jth.12011
Journal article

415 Activated Protein C (APC) Alleviates Endoplasmic Reticulum (ER) Stress and ER Stress-Linked Apoptosis in Endothelial Cells

Alhamdi, Y. A., Wang, G., & Toh, C. (2012). 415 Activated Protein C (APC) Alleviates Endoplasmic Reticulum (ER) Stress and ER Stress-Linked Apoptosis in Endothelial Cells. Canadian Journal of Cardiology, 28(5), S255. doi:10.1016/j.cjca.2012.07.390

DOI
10.1016/j.cjca.2012.07.390
Journal article

The withdrawal of Activated Protein C from the use in patients with severe sepsis and DIC [Amendment to the BCSH guideline on disseminated intravascular coagulation].

Thachil, J., Toh, C. H., Levi, M., & Watson, H. G. (2012). The withdrawal of Activated Protein C from the use in patients with severe sepsis and DIC [Amendment to the BCSH guideline on disseminated intravascular coagulation].. British journal of haematology, 157(4), 493-494. doi:10.1111/j.1365-2141.2011.09019.x

DOI
10.1111/j.1365-2141.2011.09019.x
Journal article

Current concepts in the management of disseminated intravascular coagulation.

Thachil, J., & Toh, C. H. (2012). Current concepts in the management of disseminated intravascular coagulation.. Thrombosis research, 129 Suppl 1, S54-S59. doi:10.1016/s0049-3848(12)70017-8

DOI
10.1016/s0049-3848(12)70017-8
Journal article

2011

Lipoproteins, statins and septic haematology patients.

Thachil, J., Abrams, S., Downey, C., & Toh, C. H. (2011). Lipoproteins, statins and septic haematology patients.. British journal of haematology, 155(1), 122-123. doi:10.1111/j.1365-2141.2011.08642.x

DOI
10.1111/j.1365-2141.2011.08642.x
Journal article

Reduction of circulating histone toxicity is a major function of C-reactive protein after extensive tissue damage

DOI
10.1038/npre.2011.6264.1
Preprint

The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis

Perez-Casal, M., Thompson, V., Downey, C., Welters, I., Wyncoll, D., Thachil, J., & Toh, C. H. (2011). The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis. CRITICAL CARE, 15(4). doi:10.1186/cc10356

DOI
10.1186/cc10356
Journal article

Diagnostic efficacy of activated partial thromboplastin time waveform and procalcitonin analysis in pediatric meningococcal sepsis

Paize, F., Carrol, E., Downey, C., Parry, C. M., Green, G., Diggle, P., . . . Toh, C. -H. (2011). Diagnostic efficacy of activated partial thromboplastin time waveform and procalcitonin analysis in pediatric meningococcal sepsis. PEDIATRIC CRITICAL CARE MEDICINE, 12(6), E322-E329. doi:10.1097/PCC.0b013e3182231034

DOI
10.1097/PCC.0b013e3182231034
Journal article

Diagnostic efficacy of activated partial thromboplastin time waveform and procalcitonin analysis in pediatric meningococcal sepsis.

Paize, F., Carrol, E., Downey, C., Parry, C. M., Green, G., Diggle, P., . . . Toh, C. H. (2011). Diagnostic efficacy of activated partial thromboplastin time waveform and procalcitonin analysis in pediatric meningococcal sepsis.. Pediatr Crit Care Med, 12(6), e322-e329.

Journal article

The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis

Pérez-Casal, M., Thompson, V., Downey, C., Welters, I., Wyncoll, D., Thachil, J., & Toh, C. H. (n.d.). The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis. Critical Care, 15(4). doi:10.1186/cc10356

DOI
10.1186/cc10356
Journal article

2010

Accuracy of platelet counting by automated hematologic analyzers in acute leukemia and disseminated intravascular coagulation: potential effects of platelet activation.

Kim, S. Y., Kim, J. -E., Kim, H. K., Han, K. -S., & Toh, C. H. (2010). Accuracy of platelet counting by automated hematologic analyzers in acute leukemia and disseminated intravascular coagulation: potential effects of platelet activation.. American journal of clinical pathology, 134(4), 634-647. doi:10.1309/ajcp88jylrcsrxpp

DOI
10.1309/ajcp88jylrcsrxpp
Journal article

Modified non-overt DIC diagnostic criteria predict the early phase of overt-DIC.

Wada, H., Hatada, T., Okamoto, K., Uchiyama, T., Kawasugi, K., Mayumi, T., . . . Japanese Society of Thrombosis Hemostasis/DIC subcommittee. (2010). Modified non-overt DIC diagnostic criteria predict the early phase of overt-DIC.. American journal of hematology, 85(9), 691-694. doi:10.1002/ajh.21783

DOI
10.1002/ajh.21783
Journal article

Application of the international normalized ratio in the scoring system for disseminated intravascular coagulation.

Kim, H. K., Hong, K. H., Toh, C. H., & Scientific and Standardization Committee on DIC of The International Society on THrombosis and Haemostasis. (2010). Application of the international normalized ratio in the scoring system for disseminated intravascular coagulation.. Journal of thrombosis and haemostasis : JTH, 8(5), 1116-1118. doi:10.1111/j.1538-7836.2010.03834.x

DOI
10.1111/j.1538-7836.2010.03834.x
Journal article

Appropriate use of D-dimer in hospital patients.

Thachil, J., Fitzmaurice, D. A., & Toh, C. H. (2010). Appropriate use of D-dimer in hospital patients.. The American journal of medicine, 123(1), 17-19. doi:10.1016/j.amjmed.2009.09.011

DOI
10.1016/j.amjmed.2009.09.011
Journal article

Non-malignant haematology research in the UK: looking forward to new opportunities.

Collins, P. W., Baglin, T. P., Dang, R., Evans, G., Greaves, M., Laffan, M., . . . Toh, C. H. (2010). Non-malignant haematology research in the UK: looking forward to new opportunities.. Br J Haematol, 150(6), 732-736.

Journal article

2009

Effects of <i>CYP4F2</i> genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy

Zhang, J. E., Jorgensen, A. L., Alfirevic, A., Williamson, P. R., Toh, C. H., Park, B. K., & Pirmohamed, M. (2009). Effects of <i>CYP4F2</i> genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy. PHARMACOGENETICS AND GENOMICS, 19(10), 781-789. doi:10.1097/FPC.0b013e3283311347

DOI
10.1097/FPC.0b013e3283311347
Journal article

Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study

Jorgensen, A. L., Al-Zubiedi, S., Zhang, J. E., Keniry, A., Hanson, A., Hughes, D. A., . . . Pirmohamed, M. (2009). Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study. PHARMACOGENETICS AND GENOMICS, 19(10), 800-812. doi:10.1097/FPC.0b013e3283317ab5

DOI
10.1097/FPC.0b013e3283317ab5
Journal article

Disseminated intravascular coagulation in obstetric disorders and its acute haematological management.

Thachil, J., & Toh, C. -H. (2009). Disseminated intravascular coagulation in obstetric disorders and its acute haematological management.. Blood reviews, 23(4), 167-176. doi:10.1016/j.blre.2009.04.002

DOI
10.1016/j.blre.2009.04.002
Journal article

Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology.

Levi, M., Toh, C. H., Thachil, J., & Watson, H. G. (2009). Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology.. British journal of haematology, 145(1), 24-33. doi:10.1111/j.1365-2141.2009.07600.x

DOI
10.1111/j.1365-2141.2009.07600.x
Journal article

Guidelines for the diagnosis and management of disseminated intravascular coagulation.

Levi, M., Toh, C. H., Thachil, J., & Watson, H. G. (2009). Guidelines for the diagnosis and management of disseminated intravascular coagulation.. Br J Haematol, 94, 387-394.

Journal article

2007

The formation of a Ca2+-dependent complex of C-reactive protein and very low density lipoprotein causes the biphasic transmittance waveform

Nesheim, M., Samis, J., Walker, J., Fischer, T., Tejidor, L., Jones, G., . . . Toh, C. H. (2007). The formation of a Ca2+-dependent complex of C-reactive protein and very low density lipoprotein causes the biphasic transmittance waveform. BMC Pharmacology, 7(S1). doi:10.1186/1471-2210-7-s1-p42

DOI
10.1186/1471-2210-7-s1-p42
Journal article

The scoring system of the Scientific and Standardisation Committee on Disseminated Intravascular Coagulation of the International Society on Thrombosis and Haemostasis: a 5-year overview.

Toh, C. H., & Hoots, W. K. (2007). The scoring system of the Scientific and Standardisation Committee on Disseminated Intravascular Coagulation of the International Society on Thrombosis and Haemostasis: a 5-year overview.. J Thromb Haemost, 5, 604-606.

Journal article

2006

Disseminated intravascular coagulation

Toh, C. H. (2006). Disseminated intravascular coagulation. In N. S. Young, S. L. Gerson, & K. A. High (Eds.), Clinical Hematology (Vol. 1, pp. 1134-1143). Philadelphia: Elsevier.

Chapter

2005

Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells.

Farahani, M., Treweeke, A. T., Toh, C. H., Till, K. J., Harris, R. J., Cawley, J. C., . . . Chen, H. (2005). Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells.. Leukemia, 19(4), 524-530. doi:10.1038/sj.leu.2403631

DOI
10.1038/sj.leu.2403631
Journal article

Activated protein C induces the release of microparticle-associated endothelial protein C receptor.

Pérez-Casal, M., Downey, C., Fukudome, K., Marx, G., & Toh, C. H. (2005). Activated protein C induces the release of microparticle-associated endothelial protein C receptor.. Blood, 105(4), 1515-1522. doi:10.1182/blood-2004-05-1896

DOI
10.1182/blood-2004-05-1896
Journal article

Back to the future testing in disseminated intravascular coagulation

Toh, C. H., & Downey, C. (2005). Back to the future testing in disseminated intravascular coagulation. Unknown Journal, 16(8), 535-542.

Journal article

Performance and prognostic importance of a new clinical and laboratory scoring system for identifying non-overt disseminated intravascular coagulation.

Toh, C. H., & Downey, C. (2005). Performance and prognostic importance of a new clinical and laboratory scoring system for identifying non-overt disseminated intravascular coagulation.. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 16(1), 69-74. doi:10.1097/00001721-200501000-00011

DOI
10.1097/00001721-200501000-00011
Journal article

The use of clot waveform analysis in sepsis

Toh, C. H. (2005). The use of clot waveform analysis in sepsis. Unknown Journal, 4, 103-107.

Journal article

Marx, G., Swaraj, S., Breen, A., Ritchie, G., Shenkin, A., Toh, C., & Leuwer, M. (2005). Unknown Title. Critical Care, 9(Suppl 1), P167. doi:10.1186/cc3230

DOI
10.1186/cc3230
Journal article

2004

Thrombin activatable fibrinolysis inhibitor and its fibrinolytic effect in normal pregnancy.

Mousa, H. A., Downey, C., Alfirevic, Z., & Toh, C. -H. (2004). Thrombin activatable fibrinolysis inhibitor and its fibrinolytic effect in normal pregnancy.. Thrombosis and haemostasis, 92(5), 1025-1031. doi:10.1160/th04-06-0387

DOI
10.1160/th04-06-0387
Journal article

Temporal changes in factors associated with neutrophil elastase and coagulation in intensive care patients with a biphasic waveform and disseminated intravascular coagulation.

Samis, J. A., Stewart, K. A., Toh, C. H., Day, A., Downey, C., & Nesheim, M. E. (2004). Temporal changes in factors associated with neutrophil elastase and coagulation in intensive care patients with a biphasic waveform and disseminated intravascular coagulation.. Journal of thrombosis and haemostasis : JTH, 2(9), 1535-1544. doi:10.1111/j.1538-7836.2004.00826.x

DOI
10.1111/j.1538-7836.2004.00826.x
Journal article

Prothrombinase enhancement through quantitative and qualitative changes affecting very low density lipoprotein in complex with C-reactive protein.

Dennis, M. W., Downey, C., Brufatto, N., Nesheim, M. E., Stevenson, K., & Toh, C. H. (2004). Prothrombinase enhancement through quantitative and qualitative changes affecting very low density lipoprotein in complex with C-reactive protein.. Thrombosis and haemostasis, 91(3), 522-530. doi:10.1160/th03-08-0548

DOI
10.1160/th03-08-0548
Journal article

Computational aspects of protein functionality

Paton, R., & Toh, C. H. (2004). Computational aspects of protein functionality. Unknown Journal, 5, 85-90.

Journal article

2003

Acquired activated protein C resistance may be a risk factor for recurrent fetal loss.

Dawood, F., Farquharson, R., Quenby, S., & Toh, C. H. (2003). Acquired activated protein C resistance may be a risk factor for recurrent fetal loss.. Fertility and sterility, 80(3), 649-650. doi:10.1016/s0015-0282(03)00972-5

DOI
10.1016/s0015-0282(03)00972-5
Journal article

A Longitudinal Study of Maternal Dose Response to Low Molecular Weight Heparin in Pregnancy

Sephton, V., Farquharson, R. G., Topping, J., Quenby, S. M., Cowan, C., Back, D. J., & Toh, C. H. (2003). A Longitudinal Study of Maternal Dose Response to Low Molecular Weight Heparin in Pregnancy. Obstetrics &amp; Gynecology, 101(6), 1307-1311. doi:10.1097/00006250-200306000-00028

DOI
10.1097/00006250-200306000-00028
Journal article

A longitudinal study of maternal dose response to low molecular weight heparin in pregnancy

Sephton, V., Farquharson, R. G., Topping, J., Quenby, S. M., Cowan, C., Back, D. J., & Toh, C. H. (2003). A longitudinal study of maternal dose response to low molecular weight heparin in pregnancy. OBSTETRICS AND GYNECOLOGY, 101(6), 1307-1311. doi:10.1016/S0029-7844(03)00340-5

DOI
10.1016/S0029-7844(03)00340-5
Journal article

Characterisation of thrombin activatable fibrinolysis inhibitor in normal and acquired haemostatic dysfunction

Toh, C. H. (2003). Characterisation of thrombin activatable fibrinolysis inhibitor in normal and acquired haemostatic dysfunction. Unknown Journal, 14(Suppl), 69-72.

Journal article

DIC 2002: a review on disseminated intravascular coagulation

Toh, C. H., & Dennis, M. (2003). DIC 2002: a review on disseminated intravascular coagulation. Unknown Journal, 8(2), 65-71.

Journal article

Disseminated intravascular coagulation: Old disease, new hope

Toh, C. H., & Dennis, M. (2003). Disseminated intravascular coagulation: Old disease, new hope. Unknown Journal, 327(7421), 974-977.

Journal article

Early identification of sepsis and mortality risks through simple, rapid clot-waveform analysis - Implications of lipoprotein-complexed C reactive protein formation

Toh, C. H., Ticknor, L. O., Downey, C., Giles, A. R., Paton, R. C., & Wenstone, R. (2003). Early identification of sepsis and mortality risks through simple, rapid clot-waveform analysis - Implications of lipoprotein-complexed C reactive protein formation. INTENSIVE CARE MEDICINE, 29(1), 55-61. doi:10.1007/s00134-002-1557-2

DOI
10.1007/s00134-002-1557-2
Journal article

Lipoprotein-complexed C reactive protein: new wave in sepsis management

Toh, C. H., & Breen, A. (2003). Lipoprotein-complexed C reactive protein: new wave in sepsis management. Unknown Journal, 13, 17-21.

Journal article

2002

Biphasic transmittance waveform in the APTT coagulation assay is due to the formation of a Ca<SUP>++</SUP>-dependent complex of C-reactive protein with very-low-density lipoprotein and is a novel marker of impending disseminated intravascular coagulation

Toh, C. H., Samis, J., Downey, C., Walker, J., Becker, L., Brufatto, N., . . . Nesheim, M. (2002). Biphasic transmittance waveform in the APTT coagulation assay is due to the formation of a Ca<SUP>++</SUP>-dependent complex of C-reactive protein with very-low-density lipoprotein and is a novel marker of impending disseminated intravascular coagulation. BLOOD, 100(7), 2522-2529. doi:10.1182/blood.V100.7.2522

DOI
10.1182/blood.V100.7.2522
Journal article

Lipoprotein-complexed C-reactive protein and the biphasic transmittance waveform in critically ill patients.

Nesheim, M., Samis, J., Walker, J., Becker, L., Brufatto, N., Fischer, T., . . . Toh, C. H. (2002). Lipoprotein-complexed C-reactive protein and the biphasic transmittance waveform in critically ill patients.. Blood reviews, 16 Suppl 1, S15-S22.

Journal article

2001

Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation.

Taylor, F. B., Toh, C. H., Hoots, W. K., Wada, H., Levi, M., & Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). (2001). Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation.. Thrombosis and haemostasis, 86(5), 1327-1330.

Journal article

The formation of a CA2+-dependent complex of C-reactive protein and very low density lipoprotein causes the biphasic transmittance waveform

Nesheim, M., Samis, J., Walker, J., Fischer, T., Tejidor, L., Jones, G., . . . Toh, C. H. (n.d.). The formation of a CA2+-dependent complex of C-reactive protein and very low density lipoprotein causes the biphasic transmittance waveform. BMC News and views, 1(S2). doi:10.1186/2048-4623-1-s2-007

DOI
10.1186/2048-4623-1-s2-007
Journal article

Aberrant dimerization of von Willebrand factor as the result of mutations in the carboxy-terminal region: identification of 3 mutations in members of 3 different families with type 2A (phenotype IID) von Willebrand disease.

Enayat, M. S., Guilliatt, A. M., Surdhar, G. K., Jenkins, P. V., Pasi, K. J., Toh, C. H., . . . Hill, F. G. (2001). Aberrant dimerization of von Willebrand factor as the result of mutations in the carboxy-terminal region: identification of 3 mutations in members of 3 different families with type 2A (phenotype IID) von Willebrand disease.. Blood, 98(3), 674-680. doi:10.1182/blood.v98.3.674

DOI
10.1182/blood.v98.3.674
Journal article

Postnatal Screening for Thrombophilia in Women With Severe Pregnancy Complications

ALFIREVIC, Z., MOUSA, H. A., MARTLEW, V., BRISCOE, L., PEREZ-CASAL, M., & TOH, C. H. (2001). Postnatal Screening for Thrombophilia in Women With Severe Pregnancy Complications. Obstetrics &amp; Gynecology, 97(5), 753-759. doi:10.1097/00006250-200105000-00021

DOI
10.1097/00006250-200105000-00021
Journal article

2000

The value of the aptt waveform in predicting mortality and haemostatic dysfunction

Toh, C. H., Downey, C., Wenstone, R., Paton, R., & Ticknor, L. (2000). The value of the aptt waveform in predicting mortality and haemostatic dysfunction. Blood, 96(11 PART I).

Journal article

In vitro and in vivo production of vascular endothelial growth factor by chronic lymphocytic leukemia cells.

Chen, H., Treweeke, A. T., West, D. C., Till, K. J., Cawley, J. C., Zuzel, M., & Toh, C. H. (2000). In vitro and in vivo production of vascular endothelial growth factor by chronic lymphocytic leukemia cells.. Blood, 96(9), 3181-3187.

Journal article

What clinical significance has the presence of the homozygous G20210A prothrombin gene mutation in a healthy woman?

Martlew, V. J., Perez-Casal, M., Alfirevic, Z., & Toh, C. H. (2000). What clinical significance has the presence of the homozygous G20210A prothrombin gene mutation in a healthy woman?. Thrombosis and haemostasis, 84(2), 355-356.

Journal article

1999

07 The differential regulation of the endothelial protein C receptor (EPCR) and thrombomodulin by inflammatory cytokines

Oates, M., Perez-Casal, M. M., Chen, H. J., & Toh, C. H. (1999). 07 The differential regulation of the endothelial protein C receptor (EPCR) and thrombomodulin by inflammatory cytokines. Blood Coagulation &amp; Fibrinolysis, 10(8), 532. doi:10.1097/00001721-199912000-00019

DOI
10.1097/00001721-199912000-00019
Journal article

1997

A cell model for studies on the function of the endothelial protein C receptor

Oates, M., Chen, H. J., & Toh, C. H. (1997). A cell model for studies on the function of the endothelial protein C receptor. Blood Coagulation &amp; Fibrinolysis, 8(7), 463. doi:10.1097/00001721-199710000-00024

DOI
10.1097/00001721-199710000-00024
Journal article

Evaluation of two simplified methods for genotyping hepatitis C virus

Khan, R. U., Tong, C. Y. W., Bloom, S., Gilmore, I. T., Toh, C. H., BoltonMaggs, P. H., . . . Hart, C. A. (1997). Evaluation of two simplified methods for genotyping hepatitis C virus. JOURNAL OF MEDICAL VIROLOGY, 52(1), 35-41. doi:3.0.CO;2-S">10.1002/(SICI)1096-9071(199705)52:1<35::AID-JMV7>3.0.CO;2-S

DOI
10.1002/(SICI)1096-9071(199705)52:1<35::AID-JMV7>3.0.CO;2-S
Journal article