Publications
Selected publications
- Ebola virus antibody decay-stimulation in a high proportion of survivors (Journal article - 2021)
- Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4+ T-lymphocyte responses and HIV-1 infection in vitro (Journal article - 2019)
- DC-SIGN Polymorphisms Associated with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users (Journal article - 2018)
- Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4<SUP>+</SUP> T lymphocytes (Journal article - 2005)
- Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection (Journal article - 1996)
- HIV-1 entry into CD4(+) cells is mediated by the chemokine receptor CC-CKR-5 (Journal article - 1996)
- Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures (Journal article - 1996)
2024
SARS-CoV-2 S, M and E Structural Proteins Down-modulate HIV-1 LTR Activity and Modulate Endoplasmic Reticulum Stress Responses
Development of a pseudo-typed virus particle based method to determine the efficacy of virucidal agents.
Thomas, J., Mughal, F., Roper, K. J., Kotsiri, A., Albalawi, W., Alshehri, A., . . . Hoptroff, M. (2024). Development of a pseudo-typed virus particle based method to determine the efficacy of virucidal agents.. Scientific reports, 14(1), 2174. doi:10.1038/s41598-024-52177-2
2023
The ecology of viruses in urban rodents with a focus on SARS-CoV-2
Fisher, A. M., Airey, G., Liu, Y., Gemmell, M., Thomas, J., Bentley, E. G., . . . Viney, M. (2023). The ecology of viruses in urban rodents with a focus on SARS-CoV-2. EMERGING MICROBES & INFECTIONS, 12(1). doi:10.1080/22221751.2023.2217940
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2023). Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 14(1), 8487. doi:10.1038/s41467-023-42320-4
Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial.
Rovin, B. H., Barratt, J., Heerspink, H. J. L., Alpers, C. E., Bieler, S., Chae, D. -W., . . . DUPRO steering committee and PROTECT Investigators. (2023). Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial.. Lancet (London, England), 402(10417), 2077-2090. doi:10.1016/s0140-6736(23)02302-4
41 Generation of a SARS-CoV-2 pseudotyped viral particle system enabling for the study of cell-types of infection and patient sera neutralisation
Alshehri, A., Paxton, B., Pollakis, G., Thomas, J., Roper, K., & Albalawi, W. (2023). 41 Generation of a SARS-CoV-2 pseudotyped viral particle system enabling for the study of cell-types of infection and patient sera neutralisation. Clinical Infection in Practice, 20, 100301. doi:10.1016/j.clinpr.2023.100301
A multi-country analysis of COVID-19 hospitalizations by vaccination status.
Gonçalves, B. P., Jassat, W., Baruch, J., Hashmi, M., Rojek, A., Dasgupta, A., . . . ISARIC Clinical Characterisation Group. (2023). A multi-country analysis of COVID-19 hospitalizations by vaccination status.. Med (New York, N.Y.), 4(11), 797-812.e2. doi:10.1016/j.medj.2023.08.005
Liver injury in hospitalized patients with COVID-19: An International observational cohort study.
Tirupakuzhi Vijayaraghavan, B. K., Bishnu, S., Baruch, J., Citarella, B. W., Kartsonaki, C., Meeyai, A., . . . ISARIC Clinical Characterisation Group. (2023). Liver injury in hospitalized patients with COVID-19: An International observational cohort study.. PloS one, 18(9), e0277859. doi:10.1371/journal.pone.0277859
Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera.
Roper, K. J., Thomas, J., Albalawi, W., Maddocks, E., Dobson, S., Alshehri, A., . . . Pollakis, G. (2023). Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera.. Scientific reports, 13(1), 15014. doi:10.1038/s41598-023-41928-2
A second update on mapping the human genetic architecture of COVID-19.
COVID-19 Host Genetics Initiative. (2023). A second update on mapping the human genetic architecture of COVID-19.. Nature, 621(7977), E7-E26. doi:10.1038/s41586-023-06355-3
Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19
Wainstein, M., Spyrison, N., Dai, D., Ghadimi, M., Chávez-Iñiguez, J. S., Rizo-Topete, L., . . . Zucman, D. (2023). Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19. Kidney International Reports, 8(8), 1514-1530. doi:10.1016/j.ekir.2023.05.015
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (vol 617, pg 764, 2023)
Pairo-Castineira, E., Rawlik, K., Bretherick, A. D., Qi, T., Wu, Y., Nassiri, I., . . . Baillie, J. K. (2023). GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (vol 617, pg 764, 2023). NATURE. doi:10.1038/s41586-023-06383-z
Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
Griffee, M. J., Bozza, P. T., Reyes, L. F., Eddington, D. P., Rosenberger, D., Merson, L., . . . Zucman, D. (2023). Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry. Research and Practice in Thrombosis and Haemostasis, 7(5), 102142. doi:10.1016/j.rpth.2023.102142
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
Pairo-Castineira, E., Rawlik, K., Bretherick, A. D., Qi, T., Wu, Y., Nassiri, I., . . . Baillie, J. K. (2023). GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. NATURE, 617(7962), 764-+. doi:10.1038/s41586-023-06034-3
Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial.
Heerspink, H. J. L., Radhakrishnan, J., Alpers, C. E., Barratt, J., Bieler, S., Diva, U., . . . PROTECT Investigators. (2023). Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial.. Lancet (London, England), 401(10388), 1584-1594. doi:10.1016/s0140-6736(23)00569-x
Neurological manifestations of COVID-19 in adults and children.
Cho, S. -M., White, N., Premraj, L., Battaglini, D., Fanning, J., Suen, J., . . . ISARIC Clinical Characterisation Group. (2023). Neurological manifestations of COVID-19 in adults and children.. Brain : a journal of neurology, 146(4), 1648-1661. doi:10.1093/brain/awac332
Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID-19 cohort.
Shah, N., Xue, B., Xu, Z., Yang, H., Marwali, E., Dalton, H., . . . ISARIC Clinical Characterisation Group. (2023). Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID-19 cohort.. Artificial organs. doi:10.1111/aor.14542
A Quantitative Method for the Study of HIV-1 and Mycobacterium tuberculosis Coinfection
Donnellan, S., Pennington, S. H., Ruggiero, A., Martinez-Rodriguez, C., Pouget, M., Thomas, J., . . . Paxton, W. A. (2023). A Quantitative Method for the Study of HIV-1 and Mycobacterium tuberculosis Coinfection. JOURNAL OF INFECTIOUS DISEASES, 227(5), 708-713. doi:10.1093/infdis/jiac491
Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19.
Kartsonaki, C., Baillie, J. K., Barrio, N. G., Baruch, J., Beane, A., Blumberg, L., . . . ISARIC Clinical Characterisation Group. (2023). Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19.. International journal of epidemiology, dyad012. doi:10.1093/ije/dyad012
Glycan dependent phenotype differences of HIV-1 generated from macrophage versus CD4+ T helper cell populations
Heeregrave, E. J., Thomas, J., van Capel, T. M., de Jong, E. C., Pollakis, G., & Paxton, W. A. (n.d.). Glycan dependent phenotype differences of HIV-1 generated from macrophage versus CD4+ T helper cell populations. Frontiers in Immunology, 14. doi:10.3389/fimmu.2023.1107349
SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study
Parker, E., Thomas, J., Roper, K. J., Ijaz, S., Edwards, T., Marchesin, F., . . . Pollakis, G. (2023). SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study. FRONTIERS IN IMMUNOLOGY, 14. doi:10.3389/fimmu.2023.1146702
SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination
Liew, F., Talwar, S., Cross, A., Willett, B. J., Scott, S., Logan, N., . . . Openshaw, P. J. M. (2023). SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. EBIOMEDICINE, 87. doi:10.1016/j.ebiom.2022.104402
2022
Symptom-based case definitions for COVID-19: Time and geographical variations for detection at hospital admission among 260,000 patients.
Baruch, J., Rojek, A., Kartsonaki, C., Vijayaraghavan, B. K. T., Gonçalves, B. P., Pritchard, M. G., . . . ISARIC Clinical Characterisation Group. (2022). Symptom-based case definitions for COVID-19: Time and geographical variations for detection at hospital admission among 260,000 patients.. Influenza and other respiratory viruses, 16(6), 1040-1050. doi:10.1111/irv.13039
Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study
Vink, E., Davis, C., MacLean, A., Pascall, D., McDonald, S. E., Gunson, R., . . . Ho, A. (2022). Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. OPEN FORUM INFECTIOUS DISEASES, 9(11). doi:10.1093/ofid/ofac531
Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.
Siggins, M. K., Davies, K., Fellows, R., Thwaites, R. S., Baillie, J. K., Semple, M. G., . . . ISARIC4C Investigators. (2022). Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.. Immunology. doi:10.1111/imm.13585
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
Reyes, L. F., Murthy, S., Garcia-Gallo, E., Merson, L., Ibanez-Prada, E. D., Rello, J., . . . Olliaro, P. L. (2022). Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. CRITICAL CARE, 26(1). doi:10.1186/s13054-022-04155-1
Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number
Keeling, M. J., Dyson, L., Guyver-Fletcher, G., Holmes, A., Semple, M. G., Tildesley, M. J., & Hill, E. M. (2022). Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number. STATISTICAL METHODS IN MEDICAL RESEARCH, 31(9), 1716-1737. doi:10.1177/09622802211070257
Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients
Ijaz, S., Dicks, S., Jegatheesan, K., Parker, E., Katsanovskaja, K., Vink, E., . . . Tedder, R. S. (2022). Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients. JOURNAL OF INFECTION, 85(2), 152-160. doi:10.1016/j.jinf.2022.05.033
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19
Garcia-Gallo, E., Merson, L., Kennon, K., Kelly, S., Citarella, B. W., Fryer, D. V., . . . Reyes, L. F. (2022). ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19. SCIENTIFIC DATA, 9(1). doi:10.1038/s41597-022-01534-9
Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study
Millar, J. E., Neyton, L., Seth, S., Dunning, J., Merson, L., Murthy, S., . . . Baillie, J. K. (2022). Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-08032-3
Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study
Narhi, F., Moonesinghe, S. R., Shenkin, S. D., Drake, T. M., Mulholland, R. H., Donegan, C., . . . Docherty, A. B. (2022). Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. LANCET DIGITAL HEALTH, 4(4). Retrieved from https://www.webofscience.com/
The HCV Envelope Glycoprotein Down-Modulates NF-κB Signalling and Associates With Stimulation of the Host Endoplasmic Reticulum Stress Pathway
McKay, L. G. A., Thomas, J., Albalawi, W., Fattaccioli, A., Dieu, M., Ruggiero, A., . . . Paxton, W. A. (2022). The HCV Envelope Glycoprotein Down-Modulates NF-κB Signalling and Associates With Stimulation of the Host Endoplasmic Reticulum Stress Pathway. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.831695
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (2022). SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. Cell, 185(3), 467-484.e15. doi:10.1016/j.cell.2021.12.046
Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol
Knight, S. R., Gupta, R. K., Ho, A., Pius, R., Buchan, I., Carson, G., . . . Harrison, E. M. (2022). Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. THORAX, 77(6), 606-615. doi:10.1136/thoraxjnl-2021-217629
2021
Mapping the human genetic architecture of COVID-19
Niemi, M. E. K., Karjalainen, J., Daly, M., Ganna, A., Mehtonen, J., Cordioli, M., . . . Dopazo, X. (2021). Mapping the human genetic architecture of COVID-19. NATURE, 600(7889), 472-+. doi:10.1038/s41586-021-03767-x
Measuring Proviral HIV-1 DNA: Hurdles and Improvements to an Assay Monitoring Integration Events Utilising Human <i>Alu</i> Repeat Sequences
Malatinkova, E., Thomas, J., De Spiegelaere, W., Rutsaert, S., Geretti, A. M., Pollakis, G., . . . Ruggiero, A. (2021). Measuring Proviral HIV-1 DNA: Hurdles and Improvements to an Assay Monitoring Integration Events Utilising Human <i>Alu</i> Repeat Sequences. LIFE-BASEL, 11(12). doi:10.3390/life11121410
The value of open-source clinical science in pandemic response: lessons from ISARIC
The value of open-source clinical science in pandemic response: lessons from ISARIC (2021). LANCET INFECTIOUS DISEASES, 21(12), 1623-1624. doi:10.1016/S1473-3099(21)00565-X
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells
de, S. T. I., Liu, G., Lindsey, B. B., Dong, D., Moore, S. C., Hsu, N. S., . . . Dong, T. (2021). The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. ISCIENCE, 24(11). doi:10.1016/j.isci.2021.103353
A prenylated dsRNA sensor protects against severe COVID-19
Wickenhagen, A., Sugrue, E., Lytras, S., Kuchi, S., Noerenberg, M., Turnbull, M. L., . . . Wilson, S. J. (2021). A prenylated dsRNA sensor protects against severe COVID-19. SCIENCE, 374(6567). doi:10.1126/science.abj3624
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
Abdukahil, S. A., Abe, R., Abel, L., Absil, L., Acker, A., Adachi, S., . . . Zucman, D. (2021). COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study. INFECTION, 49(5), 889-905. doi:10.1007/s15010-021-01599-5
Streptolysin O concentration and activity is central to in vivo phenotype and disease outcome in Group A Streptococcus infection
Clarke, J., Baltazar, M., Alsahag, M., Panagiotou, S., Pouget, M., Paxton, W. A., . . . Kadioglu, A. (2021). Streptolysin O concentration and activity is central to in vivo phenotype and disease outcome in Group A Streptococcus infection. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-97866-4
Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study
Russell, C. D., Fairfield, C. J., Drake, T. M., Turtle, L., Seaton, R. A., Wootton, D. G., . . . Ho, A. (2021). Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. LANCET MICROBE, 2(8), E354-E365. doi:10.1016/S2666-5247(21)00090-2
Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study
Drake, T. M., Riad, A. M., Fairfield, C. J., Egan, C., Knight, S. R., Pius, R., . . . Semple, M. G. (2021). Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. LANCET, 398(10296), 223-237. Retrieved from https://www.webofscience.com/
Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK
Docherty, A., Mulholland, R., Lone, N. I., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . Semple, M. (2021). Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 773-785. doi:10.1016/S2213-2600(21)00175-2
Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.
Drake, T. M., Fairfield, C. J., Pius, R., Knight, S. R., Norman, L., Girvan, M., . . . ISARIC4C Investigators. (2021). Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.. The Lancet. Rheumatology, 3(7), e498-e506. doi:10.1016/s2665-9913(21)00104-1
Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort
Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., . . . Khunti, K. (2021). Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort. OBESITY, 29(7), 1223-1230. doi:10.1002/oby.23178
Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK
Bloom, C. I., Drake, T. M., Docherty, A. B., Lipworth, B. J., Johnston, S. L., Nguyen-Van-Tam, J. S., . . . Openshaw, P. J. M. (2021). Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 699-711. doi:10.1016/S2213-2600(21)00013-8
Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England
Leclerc, Q. J., Fuller, N. M., Keogh, R. H., Diaz-Ordaz, K., Sekula, R., Semple, M. G., . . . Knight, G. M. (2021). Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England. BMC HEALTH SERVICES RESEARCH, 21(1). doi:10.1186/s12913-021-06509-x
Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study
Gupta, R. K., Harrison, E. M., Ho, A., Docherty, A. B., Knight, S. R., van Smeden, M., . . . Noursadeghi, M. (2021). Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(4), 349-359. doi:10.1016/S2213-2600(20)30559-2
Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol
Sigfrid, L., Drake, T., Pauley, E., Jesudason, E., Olliaro, P., Lim, W. S., . . . ISARIC4C investigators. (2021). Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol. doi:10.1101/2021.03.18.21253888
Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.
Thwaites, R. S., Sanchez Sevilla Uruchurtu, A., Siggins, M. K., Liew, F., Russell, C. D., Moore, S. C., . . . ISARIC4C investigators. (2021). Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.. Science Immunology, 6(57). doi:10.1126/sciimmunol.abg9873
Genetic mechanisms of critical illness in COVID-19
Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A. D., Rawlik, K., Pasko, D., . . . Baillie, J. K. (2021). Genetic mechanisms of critical illness in COVID-19. NATURE, 591(7848), 92-+. doi:10.1038/s41586-020-03065-y
Ebola virus antibody decay-stimulation in a high proportion of survivors
Adaken, C., Scott, J. T., Sharma, R., Gopal, R., Dicks, S., Niazi, S., . . . Pollakis, G. (2021). Ebola virus antibody decay-stimulation in a high proportion of survivors. NATURE, 590(7846), 468-+. doi:10.1038/s41586-020-03146-y
Generation of Liposomes to Study the Effect of <i>Mycobacterium Tuberculosis</i> Lipids on HIV-1 <i>cis</i>- and <i>trans</i>-Infections
Pouget, M., Coussens, A. K., Ruggiero, A., Koch, A., Thomas, J., Besra, G. S., . . . Paxton, W. A. (2021). Generation of Liposomes to Study the Effect of <i>Mycobacterium Tuberculosis</i> Lipids on HIV-1 <i>cis</i>- and <i>trans</i>-Infections. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(4). doi:10.3390/ijms22041945
Importance of patient bed pathways and length of stay differences in predicting COVID-19 bed occupancy in England
Leclerc, Q., Fuller, N., Keogh, R., Diaz-Ordaz, K., Sekula, R., Semple, M., . . . Knight, G. (2021). Importance of patient bed pathways and length of stay differences in predicting COVID-19 bed occupancy in England. doi:10.1101/2021.01.14.21249791
2020
COVID-19 symptoms at hospital admission vary with age and sex: ISARIC multinational study.
ISARIC Clinical Characterisation Group. (2020). COVID-19 symptoms at hospital admission vary with age and sex: ISARIC multinational study.. medRxiv. doi:10.1101/2020.10.26.20219519
Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020
Thompson, C. P., Grayson, N. E., Paton, R. S., Bolton, J. S., Lourenco, J., Penman, B. S., . . . Simmonds, P. (2020). Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. EUROSURVEILLANCE, 25(42), 33-41. doi:10.2807/1560-7917.ES.2020.25.42.2000685
Human Leucocyte Antigen-G (HLA-G) 3’ UTR Genetic Polymorphisms associate with HIV-1 High-Risk Seronegative Status in the Amsterdam Cohorts Studies
Christmas, S. E. (2020). Human Leucocyte Antigen-G (HLA-G) 3’ UTR Genetic Polymorphisms associate with HIV-1 High-Risk Seronegative Status in the Amsterdam Cohorts Studies. JAID, 7(1). doi:10.17303/jaid.2020.7.104
Elevated antiviral, myeloid and endothelial inflammatory markers in severe COVID-19
Thwaites, R., Sevilla Uruchurtu, A. S., Siggins, M., Liew, F., Russell, C., Moore, S., . . . Openshaw, P. J. M. (2020). Elevated antiviral, myeloid and endothelial inflammatory markers in severe COVID-19. doi:10.1101/2020.10.08.20209411
Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.
Drake, T. M., Docherty, A. B., Harrison, E. M., Quint, J. K., Adamali, H., Agnew, S., . . . ISARIC4C Investigators. (2020). Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.. Am J Respir Crit Care Med. doi:10.1164/rccm.202007-2794OC
Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.
Knight, S. R., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T. M., . . . ISARIC4C investigators. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.. BMJ: British Medical Journal, 370. doi:10.1136/bmj.m3339
Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease
Dong, X., Munoz-Basagoiti, J., Rickett, N. Y., Pollakis, G., Paxton, W. A., Guenther, S., . . . Hiscox, J. A. (2020). Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease. GENOME BIOLOGY, 21(1). doi:10.1186/s13059-020-02148-3
Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study
Swann, O., Holden, K., Turtle, L., Pollock, L., Fairfield, C., Drake, T., . . . ISARIC Coronavirus Clinical Characterisation Consortium (ISARIC4C) Investigators. (2020). Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study. BMJ, 370. doi:10.1136/bmj.m3249
Robust, reproducible clinical patterns in hospitalised patients with COVID-19
Millar, J., Neyton, L., Seth, S., Dunning, J., Merson, L., Murthy, S., . . . Baillie, K. (2020). Robust, reproducible clinical patterns in hospitalised patients with COVID-19. doi:10.1101/2020.08.14.20168088
Outcomes of COVID-19 related hospitalisation among people with HIV in the ISARIC WHO Clinical Characterisation Protocol (UK): a prospective observational study
Geretti, A., Stockdale, A., Kelly, S., Villa, G., Turtle, L., Semple, M., & Sabin, C. (2020). Outcomes of COVID-19 related hospitalisation among people with HIV in the ISARIC WHO Clinical Characterisation Protocol (UK): a prospective observational study. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 23, 13-14. Retrieved from https://www.webofscience.com/
Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score
Knight, S., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T., . . . Harrison, E. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. doi:10.1101/2020.07.30.20165464
ISARIC COVID-19 Clinical Data Report: Final report January 2020 – January 2023
ISARIC Clinical Characterisation Group., Baillie, K., Baruch, J., Beane, A., Blumberg, L., Bozza, F. A., . . . Merson, L. (2020). ISARIC COVID-19 Clinical Data Report: Final report January 2020 – January 2023. doi:10.1101/2020.07.17.20155218
Clinical characteristics of children and young people hospitalised with covid-19 in the United Kingdom: prospective multicentre observational cohort study
Swann, O., Holden, K., Turtle, L., Pollock, L., Fairfield, C., Drake, T., . . . Semple, M. (2020). Clinical characteristics of children and young people hospitalised with covid-19 in the United Kingdom: prospective multicentre observational cohort study. doi:10.1101/2020.07.14.20153320
Chloroquine Administration in Breastfeeding Mothers Associates with Increased HIV-1 Plasma Viral Loads
Paxton, W., Naarding, M., Wit, F. W. N. M., Veldhuijzen, N., Chersich, M., Kankindi, B., . . . Luchters, S. (2020). Chloroquine Administration in Breastfeeding Mothers Associates with Increased HIV-1 Plasma Viral Loads. doi:10.1101/2020.04.29.20085308
Measuring the Success of HIV-1 Cure Strategies
Thomas, J., Ruggiero, A., Paxton, W. A., & Pollakis, G. (2020). Measuring the Success of HIV-1 Cure Strategies. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 10. doi:10.3389/fcimb.2020.00134
2019
Bile-salt stimulated lipase polymorphisms do not associate with HCV susceptibility
Steba, G. S., Koekkoek, S. M., Prins, M., Brinkman, K., Kwa, D., van der Meer, J. T. M., . . . Acu, M. O. S. A. I. C. M. S. M. O. S. (2019). Bile-salt stimulated lipase polymorphisms do not associate with HCV susceptibility. VIRUS RESEARCH, 274. doi:10.1016/j.virusres.2019.197715
Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4+ T-lymphocyte responses and HIV-1 infection in vitro
Mouser, E., Pollakis, G., Smits, H., Thomas, J., Yazdanbakhsh, M., De Jong, E., & Paxton, W. (2019). Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4+ T-lymphocyte responses and HIV-1 infection in vitro. PLoS Pathogens, 15(9). doi:10.1371/journal.ppat.1007924
Streptolysin production and activity is central to<i>in vivo</i>pathotype and disease outcome in GAS infections
Clarke, J., Baltazar, M., Alsahag, M., Panagiotou, S., Pouget, M., Paxton, W., . . . Kadioglu, A. (2019). Streptolysin production and activity is central to<i>in vivo</i>pathotype and disease outcome in GAS infections. doi:10.1101/686303
SNP rs688 within the low-density lipoprotein receptor (LDL-R) gene associates with HCV susceptibility
Steba, G. S., Koekkoek, S. M., Tanck, M. W. T., Vanhommerig, J. W., van der Meer, J. T. M., Kwa, D., . . . MOSAIC (MSM observational Study of Acute infection with Hepatitis C) Study Group and the ACS (Amsterdam Cohort Studies). (2019). SNP rs688 within the low-density lipoprotein receptor (LDL-R) gene associates with HCV susceptibility. Liver International, 39(3), 463-469. doi:10.1111/liv.13978
Comparative analysis and generation of a robust HIV-1 DNA quantification assay
Thomas, J., Ruggiero, A., Procopio, F., Pantaleo, G., Paxton, A. W., & Pollakis, G. (2019). Comparative analysis and generation of a robust HIV-1 DNA quantificationassay. Journal of Virological Methods, 263, 24-31. doi:10.1016/j.jviromet.2018.10.010
2018
Development of a Sensitive qPCR Assay for Quantification of Integrated HIV-1 DNA in Peripheral Blood Mononuclear Cells
Ruggiero, A., Malatinkova, E., De Spiegelaere, W., Thomas, J., Rutsaert, S., Geretti, A. M., . . . Paxton, W. A. (n.d.). Development of a Sensitive qPCR Assay for Quantification of Integrated HIV-1 DNA in Peripheral Blood Mononuclear Cells. Journal of Virological Methods.
Detection, characterization, and enrollment of donors of Ebola convalescent plasma in Sierra Leone
Tedder, R. S., Samuel, D., Dicks, S., Scott, J. T., Ijaz, S., Smith, C. C., . . . Semple, M. G. (2018). Detection, characterization, and enrollment of donors of Ebola convalescent plasma in Sierra Leone. TRANSFUSION, 58(5), 1289-1298. doi:10.1111/trf.14580
Blood CXCR3(+) CD4 T Cells Are Enriched in Inducible Replication Competent HIV in Aviremic Antiretroviral Therapy-Treated Individuals
Banga, R., Procopio, F. A., Ruggiero, A., Noto, A., Ohmiti, K., Cavassini, M., . . . Perreau, M. (2018). Blood CXCR3(+) CD4 T Cells Are Enriched in Inducible Replication Competent HIV in Aviremic Antiretroviral Therapy-Treated Individuals. Frontiers in Immunology, 9. doi:10.3389/fimmu.2018.00144
DC-SIGN Polymorphisms Associated with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users
Steba, G. S., Koekkoek, S. M., Vanhommerig, J. W., Brinkman, K., Kwa, D., Van Der Meer, J. T. M., . . . MOSAIC (MSM observational Study of Acute infection with Hepatitis C) study group and the ACS (Amsterdam Cohort Studies). (2018). DC-SIGN Polymorphisms Associated with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users. The Journal of Infectious Diseases, 217(3), 353-357. doi:10.1093/infdis/jix587
2017
Utility of integrated HIV-1 DNA quantification in cure studies
Ruggiero, A., Malatinkova, E., Rutsaert, S., Paxton, W. A., Vandekerckhove, L., & De Spiegelaere, W. (2017). Utility of integrated HIV-1 DNA quantification in cure studies. FUTURE VIROLOGY, 12(4), 215-225. doi:10.2217/fvl-2016-0130
DC-SIGN polymorphisms associate with sexual hepatitis C virus transmission and DC-SIGN m-RNA expression levels
Steba, G. S., Koekkoek, S. M., Vanhommerig, J. W., Brinkman, K., van der Meer, J. T. M., Prins, M., . . . Schinkel, J. (2017). DC-SIGN polymorphisms associate with sexual hepatitis C virus transmission and DC-SIGN m-RNA expression levels. In JOURNAL OF HEPATOLOGY Vol. 66 (pp. S318-S319). doi:10.1016/S0168-8278(17)30958-3
2016
Why Are Some HIV-1 Subtypes More "Wimpy" at Causing Disease?
Paxton, W. A. (2016). Why Are Some HIV-1 Subtypes More "Wimpy" at Causing Disease?. EBIOMEDICINE, 13, 27-28. doi:10.1016/j.ebiom.2016.10.023
Brugia malayi Antigen (BmA) Inhibits HIV-1 Trans-Infection but Neither BmA nor ES-62 Alter HIV-1 Infectivity of DC Induced CD4(+) Th-Cells
Mouser, E. E. I. M., Pollakis, G., Yazdanbakhsh, M., Harnett, W., de Jong, E. C., & Paxton, W. A. (2016). Brugia malayi Antigen (BmA) Inhibits HIV-1 Trans-Infection but Neither BmA nor ES-62 Alter HIV-1 Infectivity of DC Induced CD4(+) Th-Cells. PLOS ONE, 11(1). doi:10.1371/journal.pone.0146527
2015
Reactivation of Neutralized HIV-1 by Dendritic Cells Is Dependent on the Epitope Bound by the Antibody
van Montfort, T., Thomas, A. A. M., Krawczyk, P. M., Berkhout, B., Sanders, R. W., & Paxton, W. A. (2015). Reactivation of Neutralized HIV-1 by Dendritic Cells Is Dependent on the Epitope Bound by the Antibody. Journal of Immunology, 195(8), 3759-3768. doi:10.4049/jimmunol.1402344
Association between gp120 envelope V1V2 and V4V5 variable loop profiles in a defined HIV-1 transmission cluster
Pollakis, G., Baan, E., van Werkhoven, M. B., Berkhout, B., Bakker, M., Jurriaans, S., & Paxton, W. A. (2015). Association between gp120 envelope V1V2 and V4V5 variable loop profiles in a defined HIV-1 transmission cluster. AIDS, 29(10), 1161-1171. doi:10.1097/QAD.0000000000000692
Colorectal Mucus Binds DC-SIGN and Inhibits HIV-1 <i>Trans</i>-Infection of CD4<SUP>+</SUP> T-Lymphocytes
Stax, M. J., Mouser, E. E. I. M., van Montfort, T., Sanders, R. W., de Vries, H. J. C., Dekker, H. L., . . . Paxton, W. A. (2015). Colorectal Mucus Binds DC-SIGN and Inhibits HIV-1 <i>Trans</i>-Infection of CD4<SUP>+</SUP> T-Lymphocytes. PLOS ONE, 10(3). doi:10.1371/journal.pone.0122020
Improved metastasis-free survival in nonadjuvantly treated postmenopausal breast cancer patients with chemokine receptor 5 del32 frameshift mutations
Span, P. N., Pollakis, G., Paxton, W. A., Sweep, F. C. G. J., Foekens, J. A., Martens, J. W. M., . . . van Laarhoven, H. W. M. (2015). Improved metastasis-free survival in nonadjuvantly treated postmenopausal breast cancer patients with chemokine receptor 5 del32 frameshift mutations. INTERNATIONAL JOURNAL OF CANCER, 136(1), 91-97. doi:10.1002/ijc.28962
2014
Increased HIV-1 Activity in Anal High-Grade Squamous Intraepithelial Lesions Compared With Unaffected Anal Mucosa in Men Who Have Sex With Men
Pollakis, G., Richel, O., Vis, J. D., Prins, J. M., Paxton, W. A., & de Vries, H. J. C. (2014). Increased HIV-1 Activity in Anal High-Grade Squamous Intraepithelial Lesions Compared With Unaffected Anal Mucosa in Men Who Have Sex With Men. CLINICAL INFECTIOUS DISEASES, 58(11), 1634-1637. doi:10.1093/cid/ciu133
The search for a T cell line for testing novel antiviral strategies against HIV-1 isolates of diverse receptor tropism and subtype origin
Herrera-Carrillo, E., Paxton, W. A., & Berkhout, B. (2014). The search for a T cell line for testing novel antiviral strategies against HIV-1 isolates of diverse receptor tropism and subtype origin. JOURNAL OF VIROLOGICAL METHODS, 203, 88-96. doi:10.1016/j.jviromet.2014.03.021
2013
Bile salt-stimulated lipase from human milk and mucosal transmission of pathogens during breastfeeding
Pollakis, G., Stax, M. J., & Paxton, W. A. (2013). Bile salt-stimulated lipase from human milk and mucosal transmission of pathogens during breastfeeding. In HANDBOOK OF DIETARY AND NUTRITIONAL ASPECTS OF HUMAN BREAST MILK (pp. 461-476). doi:10.3920/978-90-8686-764-6_26
HIV-1 Autologous Antibody Neutralization Associates with Mother to Child Transmission
Baan, E., de Ronde, A., Stax, M., Sanders, R. W., Luchters, S., Vyankandondera, J., . . . Paxton, W. A. (2013). HIV-1 Autologous Antibody Neutralization Associates with Mother to Child Transmission. PLOS ONE, 8(7). doi:10.1371/journal.pone.0069274
Human immunodeficiency virus type 1 gp120 envelope characteristics associated with disease progression differ in family members infected with genetically similar viruses
Baan, E., van der Sluis, R. M., Bakker, M. E., Bekker, V., Pajkrt, D., Jurriaans, S., . . . Pollakis, G. (2013). Human immunodeficiency virus type 1 gp120 envelope characteristics associated with disease progression differ in family members infected with genetically similar viruses. JOURNAL OF GENERAL VIROLOGY, 94, 20-29. doi:10.1099/vir.0.046185-0
Quantitation of HIV-1 DNA with a sensitive TaqMan assay that has broad subtype specificity
van der Sluis, R. M., van Montfort, T., Centlivre, M., Schopman, N. C. T., Cornelissen, M., Sanders, R. W., . . . Pollakis, G. (2013). Quantitation of HIV-1 DNA with a sensitive TaqMan assay that has broad subtype specificity. JOURNAL OF VIROLOGICAL METHODS, 187(1), 94-102. doi:10.1016/j.jviromet.2012.09.019
2012
Use of (alternative) coreceptors for HIV entry
Pollakis, G., & Paxton, W. A. (2012). Use of (alternative) coreceptors for HIV entry. CURRENT OPINION IN HIV AND AIDS, 7(5), 440-449. doi:10.1097/COH.0b013e328356e9f3
HIV Type 1 Mother-to-Child Transmission Facilitated by Distinctive Glycosylation Sites in the gp120 Envelope Glycoprotein
Baan, E., de Ronde, A., Luchters, S., Vyankandondera, J., Lange, J. M., Pollakis, G., & Paxton, W. A. (2012). HIV Type 1 Mother-to-Child Transmission Facilitated by Distinctive Glycosylation Sites in the gp120 Envelope Glycoprotein. AIDS RESEARCH AND HUMAN RETROVIRUSES, 28(7), 715-724. doi:10.1089/aid.2011.0023
Effects of helminths and <i>Mycobacterium tuberculosis</i> infection on HIV-1: a cellular immunological perspective
Mouser, E. E. I. M., Pollakis, G., & Paxton, W. A. (2012). Effects of helminths and <i>Mycobacterium tuberculosis</i> infection on HIV-1: a cellular immunological perspective. CURRENT OPINION IN HIV AND AIDS, 7(3), 260-267. doi:10.1097/COH.0b013e3283521144
HIV-1 Disease Progression Is Associated with Bile-Salt Stimulated Lipase (<i>BSSL</i>) Gene Polymorphism
Stax, M. J., Kootstra, N. A., van 't Wout, A. B., Tanck, M. W. T., Bakker, M., Pollakis, G., & Paxton, W. A. (2012). HIV-1 Disease Progression Is Associated with Bile-Salt Stimulated Lipase (<i>BSSL</i>) Gene Polymorphism. PLOS ONE, 7(3). doi:10.1371/journal.pone.0032534
Transmission of Two Distinct HIV Type 1 Strains to an Individual That Were Harbored for Many Years by Another
van Werkhoven, M. B., Baan, E., Bakker, M., Jurriaans, S., Paxton, W. A., & Pollakis, G. (2012). Transmission of Two Distinct HIV Type 1 Strains to an Individual That Were Harbored for Many Years by Another. AIDS RESEARCH AND HUMAN RETROVIRUSES, 28(2), 225-227. doi:10.1089/aid.2011.0178
2011
Editorial introductions
&NA;. (2011). Editorial introductions. Current Opinion in HIV and AIDS, 6(5), vii. doi:10.1097/coh.0b013e32834af4a7
Innate immune factors associated with HIV-1 transmission
Pollakis, G., Stax, M. J., & Paxton, W. A. (2011). Innate immune factors associated with HIV-1 transmission. CURRENT OPINION IN HIV AND AIDS, 6(5), 341-347. doi:10.1097/COH.0b013e3283499e11
Binding of Human Milk to Pathogen Receptor DC-SIGN Varies with Bile Salt-Stimulated Lipase (BSSL) Gene Polymorphism
Stax, M. J., Naarding, M. A., Tanck, M. W. T., Lindquist, S., Hernell, O., Lyle, R., . . . Paxton, W. A. (2011). Binding of Human Milk to Pathogen Receptor DC-SIGN Varies with Bile Salt-Stimulated Lipase (BSSL) Gene Polymorphism. PLOS ONE, 6(2). doi:10.1371/journal.pone.0017316
Altered dynamics and differential infection profiles of lymphoid and myeloid cell subsets during acute and chronic HIV-1 infection
Centlivre, M., Legrand, N., Steingrover, R., van der Sluis, R., Grijsen, M. L., Bakker, M., . . . Pollakis, G. (2011). Altered dynamics and differential infection profiles of lymphoid and myeloid cell subsets during acute and chronic HIV-1 infection. JOURNAL OF LEUKOCYTE BIOLOGY, 89(5), 785-795. doi:10.1189/jlb.0410231
Sexual Transmission of Hepatitis C Virus in Human Immunodeficiency Virus-Negative Men Who Have Sex With Men: A Series of Case Reports
van de Laar, T. J. W., Paxton, W. A., Zorgdrager, F., Cornelissen, M., & de Vries, H. J. C. (2011). Sexual Transmission of Hepatitis C Virus in Human Immunodeficiency Virus-Negative Men Who Have Sex With Men: A Series of Case Reports. SEXUALLY TRANSMITTED DISEASES, 38(2), 102-104. doi:10.1097/OLQ.0b013e3181ec9de5
HIV-1 disease progression is associated with bile-salt stimulated lipase (BSSL) gene polymorphism
Stax, M. J., Kootstra, N. A., van't Wout, A. B., Bakker, M., Pollakis, G., & Paxton, W. A. (2011). HIV-1 disease progression is associated with bile-salt stimulated lipase (BSSL) gene polymorphism. Retrovirology, 8(Suppl 2), P65. doi:10.1186/1742-4690-8-s2-p65
Stable HIV-1 envelope glycoprotein immune complexes as vaccine immunogens
van Montfort, T., Melchers, M., van Capel, T. M. M., de Jong, E. C., Paxton, W. A., & Sanders, R. W. (2011). Stable HIV-1 envelope glycoprotein immune complexes as vaccine immunogens. Retrovirology, 8(Suppl 2), P75.
Variant cell types and host glycoproteins influencing HIV-1 infection
Paxton, W. A. (2011). Variant cell types and host glycoproteins influencing HIV-1 infection. Retrovirology, 8(Suppl 2), O28. doi:10.1186/1742-4690-8-s2-o28
2010
Preferential infection and depletion of <i>Mycobacterium tuberculosis</i>-specific CD4 T cells after HIV-1 infection
Geldmacher, C., Ngwenyama, N., Schuetz, A., Petrovas, C., Reither, K., Heeregrave, E. J., . . . Koup, R. A. (2010). Preferential infection and depletion of <i>Mycobacterium tuberculosis</i>-specific CD4 T cells after HIV-1 infection. JOURNAL OF EXPERIMENTAL MEDICINE, 207(13), 2869-2881. doi:10.1084/jem.20100090
Varied sensitivity to therapy of HIV-1 strains in CD4<SUP>+</SUP> lymphocyte sub-populations upon ART initiation
Heeregrave, E. J., Geels, M. J., Baan, E., van der Sluis, R. M., Paxton, W. A., & Pollakis, G. (2010). Varied sensitivity to therapy of HIV-1 strains in CD4<SUP>+</SUP> lymphocyte sub-populations upon ART initiation. AIDS RESEARCH AND THERAPY, 7. doi:10.1186/1742-6405-7-42
Generation of representative primary virus isolates from blood plasma after isolation of HIV-1 with CD44 MicroBeads
Cornelissen, M., Heeregrave, E. J., Zorgdrager, F., Pollakis, G., Paxton, W. A., & van der Kuyl, A. C. (2010). Generation of representative primary virus isolates from blood plasma after isolation of HIV-1 with CD44 MicroBeads. ARCHIVES OF VIROLOGY, 155(12), 2017-2022. doi:10.1007/s00705-010-0806-x
Generation of HIV-1 primary isolates representative of plasma variants using the U87.CD4 cell line
Heeregrave, E. J., Ampofo, W. K., Tetteh, J. K. A., Ofori, M., Ofori, S. B., Shah, A. S., . . . Paxton, W. A. (2010). Generation of HIV-1 primary isolates representative of plasma variants using the U87.CD4 cell line. JOURNAL OF VIROLOGICAL METHODS, 169(2), 341-350. doi:10.1016/j.jviromet.2010.08.001
HIV-1 (co)Receptors: Implications for Vaccine and Therapy Design
Pollakis, G., & Paxton, W. A. (2010). HIV-1 (co)Receptors: Implications for Vaccine and Therapy Design. CURRENT PHARMACEUTICAL DESIGN, 16(33), 3701-3715. doi:10.2174/138161210794079146
Innate immunity against HIV: a priority target for HIV prevention research
Borrow, P., Shattock, R. J., & Vyakarnam, A. (2010). Innate immunity against HIV: a priority target for HIV prevention research. RETROVIROLOGY, 7. doi:10.1186/1742-4690-7-84
Differences in HIV Type 1 RNA Plasma Load Profile of Closely Related Cocirculating Ethiopian Subtype C Strains: C and C′
Ayele, W., Mekonnen, Y., Messele, T., Mengistu, Y., Tsegaye, A., Bakker, M., . . . Pollakis, G. (2010). Differences in HIV Type 1 RNA Plasma Load Profile of Closely Related Cocirculating Ethiopian Subtype C Strains: C and C′. AIDS RESEARCH AND HUMAN RETROVIRUSES, 26(7), 805-813. doi:10.1089/aid.2009.0152
BILE SALT STIMULATED LIPASE GENOTYPES IN GHANAIAN COUPLES DISCORDANT FOR HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION
Affram, Y., Martijn, M., Pollakis, G., Sagoe, K. W., Mingle, J. A., Ampofo, W. K., . . . Jacob, B. (2010). BILE SALT STIMULATED LIPASE GENOTYPES IN GHANAIAN COUPLES DISCORDANT FOR HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 83 (pp. 199). Retrieved from https://www.webofscience.com/
2009
Natural compounds in bodily fluids which bind DC-SIGN and prevent HIV-1 capture and transfer to CD4 cells
Stax, M. J., Pollakis, G., Sprenger, R. R., Melchers, M., van Montfort, T., Sanders, R. W., . . . Paxton, W. A. (2009). Natural compounds in bodily fluids which bind DC-SIGN and prevent HIV-1 capture and transfer to CD4 cells. In RETROVIROLOGY Vol. 6. doi:10.1186/1742-4690-6-S3-P108
Lack of <i>in vivo</i> compartmentalization among HIV-1 infected naive and memory CD4<SUP>+</SUP> T cell subsets
Heeregrave, E. J., Geels, M. J., Brenchley, J. M., Laan, E., Ambrozak, D. R., van der Sluis, R. M., . . . Paxton, W. A. (2009). Lack of <i>in vivo</i> compartmentalization among HIV-1 infected naive and memory CD4<SUP>+</SUP> T cell subsets. VIROLOGY, 393(1), 24-32. doi:10.1016/j.virol.2009.07.011
HIV vaccine: it may take two to tango, but no party time yet
Berkhout, B., & Paxton, W. A. (2009). HIV vaccine: it may take two to tango, but no party time yet. RETROVIROLOGY, 6. doi:10.1186/1742-4690-6-88
Mucin 6 in seminal plasma binds DC-SIGN and potently blocks dendritic cell mediated transfer of HIV-1 to CD4<SUP>+</SUP> T-lymphocytes
Stax, M. J., van Montfort, T., Sprenger, R. R., Melchers, M., Sanders, R. W., van Leeuwen, E., . . . Paxton, W. A. (2009). Mucin 6 in seminal plasma binds DC-SIGN and potently blocks dendritic cell mediated transfer of HIV-1 to CD4<SUP>+</SUP> T-lymphocytes. VIROLOGY, 391(2), 203-211. doi:10.1016/j.virol.2009.06.011
Use of chloroquine in reducing mother to child transmission of HIV-1 during breastfeeding
Naarding, M., Luchters, S., Vyankandondera, J., Wit, F., Veldhuijzen, N., Kankindi, B., . . . Paxton, W. (2009). Use of chloroquine in reducing mother to child transmission of HIV-1 during breastfeeding. Retrovirology, 6(S1). doi:10.1186/1742-4690-6-s1-o13
RNA detection and subtype C assessment of HIV-1 in infants with diarrhea in Ethiopia.
Ayele, W., Assefa, T., Lulseged, S., Tegbaru, B., Berhanu, H., Tamene, W., . . . Pollakis, G. (2009). RNA detection and subtype C assessment of HIV-1 in infants with diarrhea in Ethiopia.. The open AIDS journal, 3, 19-23. doi:10.2174/1874613600903010019
Optimization of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins with V1/V2 Deleted, Using Virus Evolution
Bontjer, I., Land, A., Eggink, D., Verkade, E., Tuin, K., Baldwin, C., . . . Sanders, R. W. (2009). Optimization of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins with V1/V2 Deleted, Using Virus Evolution. JOURNAL OF VIROLOGY, 83(1), 368-383. doi:10.1128/JVI.01404-08
2008
Only Five of 10 Strictly Conserved Disulfide Bonds Are Essential for Folding and Eight for Function of the HIV-1 Envelope Glycoprotein
van Anken, E., Sanders, R. W., Liscaljet, I. M., Land, A., Bontjer, I., Tillemans, S., . . . Braakman, I. (2008). Only Five of 10 Strictly Conserved Disulfide Bonds Are Essential for Folding and Eight for Function of the HIV-1 Envelope Glycoprotein. MOLECULAR BIOLOGY OF THE CELL, 19(10), 4298-4309. doi:10.1091/mbc.E07-12-1282
Dendritic cells preferentially transfer CXCR4-using human immunodeficiency virus type 1 variants to CD4<SUP>+</SUP> T lymphocytes in <i>trans</i>
van Montfort, T., Thomas, A. A. M., Pollakis, G., & Paxton, W. A. (2008). Dendritic cells preferentially transfer CXCR4-using human immunodeficiency virus type 1 variants to CD4<SUP>+</SUP> T lymphocytes in <i>trans</i>. JOURNAL OF VIROLOGY, 82(16), 7886-7896. doi:10.1128/JVI.00245-08
Increased virus replication in mammalian cells by blocking intracellular innate defense responses
de Vries, W., Haasnoot, J., van der Velden, J., van Montfort, T., Zorgdrager, F., Paxton, W., . . . Berkhout, B. (2008). Increased virus replication in mammalian cells by blocking intracellular innate defense responses. GENE THERAPY, 15(7), 545-552. doi:10.1038/gt.2008.12
The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion
Sanders, R. W., van Anken, E., Nabatov, A. A., Liscaljet, M., Bontjer, I., Eggink, D., . . . Paxton, W. A. (2008). The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion. RETROVIROLOGY, 5. doi:10.1186/1742-4690-5-10
Bile-salt stimulated lipase in human milk binds DC-SIGN and inhibits HIV-1 transmission
Stax, M. J., Naarding, M. A., Speijer, D., Hernell, O., Pollakis, G., & Paxton, W. A. (2008). Bile-salt stimulated lipase in human milk binds DC-SIGN and inhibits HIV-1 transmission. Retrovirology, 5(Suppl 1), O3. doi:10.1186/1742-4690-5-s1-o3
Optimization of V1/V2-Deleted HIV-1 Envelope Glycoproteins using Evolution
Bontjer, I., Land, A., Eggink, D., Verkade, E., Tuin, K., Baldwin, C., . . . Sanders, R. W. (2008). Optimization of V1/V2-Deleted HIV-1 Envelope Glycoproteins using Evolution. In AIDS RESEARCH AND HUMAN RETROVIRUSES Vol. 24 (pp. 56). Retrieved from https://www.webofscience.com/
2007
Vaccine The controversial story of medicine’s greatest lifesaver
Vaccine The controversial story of medicine’s greatest lifesaver (2007). The Journal of clinical investigation, 117(8), 2017.
Statins Disrupt CCR5 and RANTES Expression Levels in CD4<SUP>+</SUP> T Lymphocytes In Vitro and Preferentially Decrease Infection of R5 Versus X4 HIV-1
Nabatov, A. A., Pollakis, G., Linnemann, T., Paxton, W. A., & de Baar, M. P. (2007). Statins Disrupt CCR5 and RANTES Expression Levels in CD4<SUP>+</SUP> T Lymphocytes In Vitro and Preferentially Decrease Infection of R5 Versus X4 HIV-1. PLOS ONE, 2(5). doi:10.1371/journal.pone.0000470
Characterization of an HIV-1 group m variant that is distinct from the known subtypes
Van der Hoek, L., Pollakis, G., Lukashov, V. V., Jebbink, M. F., Jeeninga, R. E., Bakker, M., . . . Berkhout, B. (2007). Characterization of an HIV-1 group m variant that is distinct from the known subtypes. AIDS RESEARCH AND HUMAN RETROVIRUSES, 23(3), 466-470. doi:10.1089/aid.2006.0184
Efficient capture of antibody neutralized HIV-1 by cells expressing DC-SIGN and transfer to CD4<SUP>+</SUP> T lymphocytes
van Montfort, T., Nabatov, A. A., Geijtenbeek, T. B. H., Pollakis, G., & Paxton, W. A. (2007). Efficient capture of antibody neutralized HIV-1 by cells expressing DC-SIGN and transfer to CD4<SUP>+</SUP> T lymphocytes. JOURNAL OF IMMUNOLOGY, 178(5), 3177-3185. doi:10.4049/jimmunol.178.5.3177
Use of dried spots of whole blood, plasma, and mother's milk collected on filter paper for measurement of human immunodeficiency virus type 1 burden
Ayele, W., Schuurman, R., Messele, T., Dorigo-Zetsma, W., Mengistu, Y., Goudsmit, J., . . . Pollakis, G. (2007). Use of dried spots of whole blood, plasma, and mother's milk collected on filter paper for measurement of human immunodeficiency virus type 1 burden. JOURNAL OF CLINICAL MICROBIOLOGY, 45(3), 891-896. doi:10.1128/JCM.01919-06
Effect of chloroquine on reducing HIV-I replication <i>in vitro</i> and the DC-SIGN mediated transfer of virus to CD<SUP>4+</SUP> T-lymphocytes
Naarding, M. A., Baan, E., Pollakis, G., & Paxton, W. A. (2007). Effect of chloroquine on reducing HIV-I replication <i>in vitro</i> and the DC-SIGN mediated transfer of virus to CD<SUP>4+</SUP> T-lymphocytes. RETROVIROLOGY, 4. doi:10.1186/1742-4690-4-6
2006
Interaction of HIV-1 with dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-expressing cells is influenced by gp120 envelope modifications associated with disease progression
Nabatov, A. A., van Montfort, T., Geijtenbeek, T. B. H., Pollakis, G., & Paxton, W. A. (2006). Interaction of HIV-1 with dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-expressing cells is influenced by gp120 envelope modifications associated with disease progression. FEBS JOURNAL, 273(21), 4944-4958. doi:10.1111/j.1742-4658.2006.05491.x
Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4<SUP>+</SUP> T cells
Naarding, M. A., Dirac, A. M., Ludwig, I. S., Speijer, D., Lindquist, S., Vestman, E. -L., . . . Paxton, W. A. (2006). Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4<SUP>+</SUP> T cells. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 50(10), 3367-3374. doi:10.1128/AAC.00593-06
CTL escape and increased viremia irrespective of HIV-specific CD4<SUP>+</SUP> T-helper responses in two HIV-infected individuals
Geels, M. J., Jansen, C. A., Baan, E., De Cuyper, I. M., van Schijndel, G. J. M., Schuitemaker, H., . . . van Baarle, D. (2006). CTL escape and increased viremia irrespective of HIV-specific CD4<SUP>+</SUP> T-helper responses in two HIV-infected individuals. VIROLOGY, 345(1), 209-219. doi:10.1016/j.virol.2005.09.023
2005
Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4<SUP>+</SUP> T lymphocytes
Naarding, M. A., Ludwig, I. S., Groot, F., Berkhout, B., Geijtenbeek, T. B. H., Pollakis, G., & Paxton, W. A. (2005). Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4<SUP>+</SUP> T lymphocytes. JOURNAL OF CLINICAL INVESTIGATION, 115(11), 3256-3264. doi:10.1172/JCI25105
Broad cross-glade T-cell responses to gag in individuals infected with human immunodeficiency virus type 1 non-B clades (A to G): Importance of HLA anchor residue conservation
Geels, M. J., Dubey, S. A., Anderson, K., Baan, E., Bakker, M., Pollakis, G., . . . Goudsmit, J. (2005). Broad cross-glade T-cell responses to gag in individuals infected with human immunodeficiency virus type 1 non-B clades (A to G): Importance of HLA anchor residue conservation. JOURNAL OF VIROLOGY, 79(17), 11247-11258. doi:10.1128/JVI.79.17.11247-11258.2005
2004
Phenotypic and genotypic comparisons of CCR5- and CXCR4-Tropic human immunodeficiency virus type 1 biological clones isolated from subtype C-infected individuals
Pollakis, G., Abebe, A., Kliphuis, A., Chalaby, M. I. M., Bakker, M., Mengistu, Y., . . . Paxton, W. A. (2004). Phenotypic and genotypic comparisons of CCR5- and CXCR4-Tropic human immunodeficiency virus type 1 biological clones isolated from subtype C-infected individuals. JOURNAL OF VIROLOGY, 78(6), 2841-2852. doi:10.1128/JVI.78.6.2841-2852.2004
Intrapatient alterations in the human immunodeficiency virus type 1 gp120 V1V2 and V3 regions differentially modulate coreceptor usage, virus inhibition by CC/CXC chemokines, soluble CD4, and the b12 and 2G12 monoclonal antibodies
Nabatov, A. A., Pollakis, G., Linnemann, T., Kliphius, A., Chalaby, M. I. M., & Paxton, W. A. (2004). Intrapatient alterations in the human immunodeficiency virus type 1 gp120 V1V2 and V3 regions differentially modulate coreceptor usage, virus inhibition by CC/CXC chemokines, soluble CD4, and the b12 and 2G12 monoclonal antibodies. JOURNAL OF VIROLOGY, 78(1), 524-530. doi:10.1128/JVI.78.1.524-530.2004
2003
Identification of sequential viral escape mutants associated with altered T-cell responses in a human immunodeficiency virus type 1-infected individual
Geels, M. J., Cornelissen, M., Schuitemaker, H., Anderson, K., Kwa, D., Maas, J., . . . Goudsmit, J. (2003). Identification of sequential viral escape mutants associated with altered T-cell responses in a human immunodeficiency virus type 1-infected individual. JOURNAL OF VIROLOGY, 77(23), 12430-12440. doi:10.1128/JVI.77.23.12430-12440.2003
2001
RANTES production from CD<SUP>4+</SUP> lymphocytes correlates with host genotype and rates of human immunodeficiency virus type 1 disease progression
Paxton, W. A., Neumann, A. U., Kang, S., Deutch, L., Brown, R. C., Koup, R. A., & Wolinsky, S. M. (2001). RANTES production from CD<SUP>4+</SUP> lymphocytes correlates with host genotype and rates of human immunodeficiency virus type 1 disease progression. In JOURNAL OF INFECTIOUS DISEASES Vol. 183 (pp. 1678-1681). doi:10.1086/320701
<i>N</i>-linked glycosylation of the HIV type-1 gp120 envelope glycoprotein as a major determinant of CCR5 and CXCR4 coreceptor utilization
Pollakis, G., Kang, S., Kliphuis, A., Chalaby, M. I. M., Goudsmit, J., & Paxton, W. A. (2001). <i>N</i>-linked glycosylation of the HIV type-1 gp120 envelope glycoprotein as a major determinant of CCR5 and CXCR4 coreceptor utilization. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(16), 13433-13441. doi:10.1074/jbc.M009779200
2000
Up-regulation of HIV coreceptors CXCR4 and CCR5 on CD4<SUP>+</SUP> T cells during human endotoxemia and after stimulation with (myco)bacterial antigens:: the role of cytokines
Juffermans, N. P., Paxton, W. A., Dekkers, P. E. P., Verbon, A., de Jonge, E., Speelman, P., . . . van der Poll, T. (2000). Up-regulation of HIV coreceptors CXCR4 and CCR5 on CD4<SUP>+</SUP> T cells during human endotoxemia and after stimulation with (myco)bacterial antigens:: the role of cytokines. BLOOD, 96(8), 2649-2654. Retrieved from https://www.webofscience.com/
Up-regulation of HIV coreceptors CXCR4 and CCR5 on CD4+ T cells during human endotoxemia and after stimulation with (myco)bacterial antigens: the role of cytokines
Juffermans, N. P., Paxton, W. A., Dekkers, P. E. P., Verbon, A., de Jonge, E., Speelman, P., . . . van der Poll, T. (2000). Up-regulation of HIV coreceptors CXCR4 and CCR5 on CD4+ T cells during human endotoxemia and after stimulation with (myco)bacterial antigens: the role of cytokines. Blood, 96(8), 2649-2654. doi:10.1182/blood.v96.8.2649.h8002649_2649_2654
1999
HIV-1 infectability of CD4<SUP>+</SUP> lymphocytes with relation to β-chemokines and the CCR5 coreceptor
Paxton, W. A., Kang, S., Liu, R., Landau, N. R., Gingeras, T. R., Wu, L. J., . . . Koup, R. A. (1999). HIV-1 infectability of CD4<SUP>+</SUP> lymphocytes with relation to β-chemokines and the CCR5 coreceptor. In IMMUNOLOGY LETTERS Vol. 66 (pp. 71-75). doi:10.1016/S0165-2478(98)00154-0
1998
The HIV type 1 coreceptor CCR5 and its role in viral transmission and disease progression
Paxton, W. A., Kang, S., & Koup, R. A. (1998). The HIV type 1 coreceptor CCR5 and its role in viral transmission and disease progression. In AIDS RESEARCH AND HUMAN RETROVIRUSES Vol. 14 (pp. S89-S92). Retrieved from https://www.webofscience.com/
Reduced HIV-1 infectability of CD4<SUP>+</SUP> lymphocytes from exposed-uninfected individuals:: Association with low expression of CCR5 and high production of β-chemokines
Paxton, W. A., Liu, R., Kang, S., Wu, L. J., Gingeras, T. R., Landau, N. R., . . . Koup, R. A. (1998). Reduced HIV-1 infectability of CD4<SUP>+</SUP> lymphocytes from exposed-uninfected individuals:: Association with low expression of CCR5 and high production of β-chemokines. VIROLOGY, 244(1), 66-73. doi:10.1006/viro.1998.9082
Chemokine receptor allelic polymorphisms: Relationships to HIV resistance and disease progression
Paxton, W. A., & Kang, S. (1998). Chemokine receptor allelic polymorphisms: Relationships to HIV resistance and disease progression. SEMINARS IN IMMUNOLOGY, 10(3), 187-194. doi:10.1006/smim.1998.0132
Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines
Trkola, A., Paxton, W. A., Monard, S. P., Hoxie, J. A., Siani, M. A., Thompson, D. A., . . . Moore, J. P. (1998). Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines. JOURNAL OF VIROLOGY, 72(1), 396-404. doi:10.1128/JVI.72.1.396-404.1998
Immature dendritic cells selectively replicate macrophagetropic (M-tropic) human immunodeficiency virus type 1, while mature cells efficiently transmit both M- and T-Tropic virus to T cells
Granelli-Piperno, A., Delgado, E., Finkel, V., Paxton, W., & Steinman, R. M. (1998). Immature dendritic cells selectively replicate macrophagetropic (M-tropic) human immunodeficiency virus type 1, while mature cells efficiently transmit both M- and T-Tropic virus to T cells. JOURNAL OF VIROLOGY, 72(4), 2733-2737. doi:10.1128/JVI.72.4.2733-2737.1998
1997
CCR-5: A hot target for drug discovery
Landau, N. R., Liu, R., DiMarzio, P., Choe, S., Ceradini, D., Yang, J., . . . Koup, R. A. (1997). CCR-5: A hot target for drug discovery. In FASEB JOURNAL Vol. 11 (pp. A855). Retrieved from https://www.webofscience.com/
CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro
Wu, L. J., Paxton, W. A., Kassam, N., Ruffing, N., Rottman, J. B., Sullivan, N., . . . Mackay, C. R. (1997). CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro. JOURNAL OF EXPERIMENTAL MEDICINE, 185(9), 1681-1691. doi:10.1084/jem.185.9.1681
Mechanisms of resistance to HIV infection
Paxton, W. A., & Koup, R. A. (1997). Mechanisms of resistance to HIV infection. SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 18(3), 323-340. doi:10.1007/BF00813501
1996
Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors
GranelliPiperno, A., Moser, B., Pope, M., Chen, D. L., Wei, Y., Isdell, F., . . . Steinman, R. M. (1996). Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors. JOURNAL OF EXPERIMENTAL MEDICINE, 184(6), 2433-2438. doi:10.1084/jem.184.6.2433
Perspective: Research highlights at the Aaron Diamond AIDS Research Center - The beta-chemokines, HIV type 1 second receptors, and exposed uninfected persons
Paxton, W. A., Dragic, T., Koup, R. A., & Moore, J. P. (1996). Perspective: Research highlights at the Aaron Diamond AIDS Research Center - The beta-chemokines, HIV type 1 second receptors, and exposed uninfected persons. AIDS RESEARCH AND HUMAN RETROVIRUSES, 12(13), 1203-1207. doi:10.1089/aid.1996.12.1203
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
Liu, R., Paxton, W. A., Choe, S., Ceradini, D., Martin, S. R., Horuk, R., . . . Landau, N. R. (1996). Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. CELL, 86(3), 367-377. doi:10.1016/S0092-8674(00)80110-5
Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures
Paxton, W. A., Martin, S. R., Tse, D., OBrien, T. R., Skurnick, J., VanDevanter, N. L., . . . Koup, R. A. (1996). Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures. NATURE MEDICINE, 2(4), 412-417. doi:10.1038/nm0496-412
HIV-1 entry into CD4(+) cells is mediated by the chemokine receptor CC-CKR-5
Dragic, T., Litwin, V., Allaway, G. P., Martin, S. R., Huang, Y. X., Nagashima, K. A., . . . Paxton, W. A. (1996). HIV-1 entry into CD4(+) cells is mediated by the chemokine receptor CC-CKR-5. NATURE, 381(6584), 667-673. doi:10.1038/381667a0
Macrophages and CD4(+) T lymphocytes from two multiply exposed, uninfected individuals resist infection with primary non-syncytium-inducing isolates of human immunodeficiency virus type 1
Connor, R. I., Paxton, W. A., Sheridan, K. E., & Koup, R. A. (1996). Macrophages and CD4(+) T lymphocytes from two multiply exposed, uninfected individuals resist infection with primary non-syncytium-inducing isolates of human immunodeficiency virus type 1. JOURNAL OF VIROLOGY, 70(12), 8758-8764. doi:10.1128/JVI.70.12.8758-8764.1996
The role of a mutant CCR5 allele in HIV-1 transmission and disease progression
Huang, Y. X., Paxton, W. A., Wolinsky, S. M., Neumann, A. U., Zhang, L. Q., He, T., . . . Koup, R. A. (1996). The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. NATURE MEDICINE, 2(11), 1240-1243. doi:10.1038/nm1196-1240
1995
DIFFERENTIAL ANTIBODY ISOTYPE REACTIVITY TO SPECIFIC ANTIGENS IN HUMAN LYMPHATIC FILARIASIS - GP15/400 PREFERENTIALLY INDUCES IMMUNOGLOBULIN-E (IGE), IGG4, AND IGG2
YAZDANBAKHSH, M., PAXTON, W. A., BRANDENBURG, A., VANREE, R., LENS, M., PARTONO, F., . . . SELKIRK, M. E. (1995). DIFFERENTIAL ANTIBODY ISOTYPE REACTIVITY TO SPECIFIC ANTIGENS IN HUMAN LYMPHATIC FILARIASIS - GP15/400 PREFERENTIALLY INDUCES IMMUNOGLOBULIN-E (IGE), IGG4, AND IGG2. INFECTION AND IMMUNITY, 63(10), 3772-3779. doi:10.1128/IAI.63.10.3772-3779.1995
1993
T-CELL RESPONSIVENESS CORRELATES DIFFERENTIALLY WITH ANTIBODY ISOTYPE LEVELS IN CLINICAL AND ASYMPTOMATIC FILARIASIS
YAZDANBAKHSH, M., PAXTON, W. A., KRUIZE, Y. C. M., SARTONO, E., KURNIAWAN, A., WOUT, A. V., . . . MAIZELS, R. M. (1993). T-CELL RESPONSIVENESS CORRELATES DIFFERENTIALLY WITH ANTIBODY ISOTYPE LEVELS IN CLINICAL AND ASYMPTOMATIC FILARIASIS. JOURNAL OF INFECTIOUS DISEASES, 167(4), 925-931. doi:10.1093/infdis/167.4.925
BRUGIA-PAHANGI AND BRUGIA-MALAYI - A SURFACE-ASSOCIATED GLYCOPROTEIN (GP15-400) IS COMPOSED OF MULTIPLE TANDEMLY REPEATED UNITS AND PROCESSED FROM A 400-KDA PRECURSOR
TWEEDIE, S., PAXTON, W. A., INGRAM, L., MAIZELS, R. M., MCREYNOLDS, L. A., & SELKIRK, M. E. (1993). BRUGIA-PAHANGI AND BRUGIA-MALAYI - A SURFACE-ASSOCIATED GLYCOPROTEIN (GP15-400) IS COMPOSED OF MULTIPLE TANDEMLY REPEATED UNITS AND PROCESSED FROM A 400-KDA PRECURSOR. EXPERIMENTAL PARASITOLOGY, 76(2), 156-164. doi:10.1006/expr.1993.1018
INCORPORATION OF VPR INTO HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VIRIONS - REQUIREMENT FOR THE P6 REGION OF GAG AND MUTATIONAL ANALYSIS
PAXTON, W., CONNOR, R. I., & LANDAU, N. R. (1993). INCORPORATION OF VPR INTO HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VIRIONS - REQUIREMENT FOR THE P6 REGION OF GAG AND MUTATIONAL ANALYSIS. JOURNAL OF VIROLOGY, 67(12), 7229-7237. doi:10.1128/JVI.67.12.7229-7237.1993
PRIMARY STRUCTURE OF AND IMMUNOGLOBULIN-E RESPONSE TO THE REPEAT SUBUNIT OF GP15/400 FROM HUMAN LYMPHATIC FILARIAL PARASITES
PAXTON, W. A., YAZDANBAKHSH, M., KURNIAWAN, A., PARTONO, F., MAIZELS, R. M., & SELKIRK, M. E. (1993). PRIMARY STRUCTURE OF AND IMMUNOGLOBULIN-E RESPONSE TO THE REPEAT SUBUNIT OF GP15/400 FROM HUMAN LYMPHATIC FILARIAL PARASITES. INFECTION AND IMMUNITY, 61(7), 2827-2833. doi:10.1128/IAI.61.7.2827-2833.1993
VPU AFFECTS THE ABILITY OF HIV-1 TO REPLICATE AND FORM SYNCYTIA IN CELLS EXPRESSING HIGH-LEVELS OF CD4
LANDAU, N. R., LENBURG, M. E., & PAXTON, W. (1993). VPU AFFECTS THE ABILITY OF HIV-1 TO REPLICATE AND FORM SYNCYTIA IN CELLS EXPRESSING HIGH-LEVELS OF CD4. In JOURNAL OF CELLULAR BIOCHEMISTRY (pp. 50). Retrieved from https://www.webofscience.com/