Publications
2021
CD36 maintains the gastric mucosa and associates with gastric disease
Jacome-Sosa, M., Miao, Z. -F., Peche, V. S., Morris, E. F., Narendran, R., Pietka, K. M., . . . Abumrad, N. A. (2021). CD36 maintains the gastric mucosa and associates with gastric disease. COMMUNICATIONS BIOLOGY, 4(1). doi:10.1038/s42003-021-02765-z
2019
A novel FTIR analysis method for rapid high-confidence discrimination of esophageal cancer
Martin, D. S., Barrett, S., Weightman, P., & Smith, C. (2019). A novel FTIR analysis method for rapid high-confidence discrimination ofesophageal cancer. Infrared Physics and Technology, 102. doi:10.1016/j.infrared.2019.103007
Integrated Omics Profiling Reveals Novel Patterns of Epigenetic Programming in Cancer-Associated Myofibroblasts
Najgebauer, H., Liloglou, T., Jithesh, P. V., Giger, O. T., Varro, A., & Sanderson, C. M. (2019). Integrated Omics Profiling Reveals Novel Patterns of Epigenetic Programming in Cancer-Associated Myofibroblasts. Carcinogenesis, 40(4), 500-512. doi:10.1093/carcin/bgz001
Recharacterization data for a geriatric gastrin polycolonal antibody
Dodd, S., Varro, A., Pritchard, D. M., & Dockray, G. J. (2019). Recharacterization data for a geriatric gastrin polycolonal antibody. DATA IN BRIEF, 24. doi:10.1016/j.dib.2019.103886
Bioelectrical impedance vector analysis (BIVA) as a method to compare body composition differences according to cancer stage and type
Nwosu, A. C., Mayland, C., Mason, S., Cox, T., Varro, A., Stanley, S., & Ellershaw, J. (n.d.). Bioelectrical impedance vector analysis (BIVA) as a method to compare body composition differences according to cancer stage and type. Clinical Nutrition ESPEN. doi:10.1016/j.clnesp.2019.02.006
Integrative Omic Profiling Reveals Unique Hypoxia Induced Signatures in Gastric Cancer Associated Myofibroblasts
Najgebauer, H., Jarnuczak, A. E., Varro, A., & Sanderson, C. M. (2019). Integrative Omic Profiling Reveals Unique Hypoxia Induced Signatures in Gastric Cancer Associated Myofibroblasts. CANCERS, 11(2). doi:10.3390/cancers11020263
Chemerin acts via CMKLR1 and GPR1 to stimulate migration and invasion of gastric cancer cells: putative role of decreased TIMP-1 and TIMP-2
Kumar, J. D., Aolymat, I., Tiszlavicz, L., Reisz, Z., Garalla, H. M., Beynon, R., . . . Varro, A. (2019). Chemerin acts via CMKLR1 and GPR1 to stimulate migration and invasion of gastric cancer cells: putative role of decreased TIMP-1 and TIMP-2. Oncotarget, 10(02), 98-112. Retrieved from https://www.oncotarget.com/article/26414/text/
Netazepide, a Gastrin/CCK2 Receptor Antagonist, Can Eradicate Gastric Neuroendocrine Tumours in PatientsWith Autoimmune Chronic Atrophic Gastritis
Boyce, M., Moore, A. R., Parsons, B., Lloyd, K., Sagatun, L., Varro, A., . . . Pritchard, D. M. (2019). Netazepide, a Gastrin/CCK2 Receptor Antagonist, Can Eradicate Gastric Neuroendocrine Tumours in PatientsWith Autoimmune Chronic Atrophic Gastritis. In PANCREAS Vol. 48 (pp. 429). Retrieved from https://www.webofscience.com/
2018
Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell
Smith, C. I., Siggel-King, M. R. F., Ingham, J., Harrison, P., Martin, D. S., Varro, A., . . . Weightman, P. (2018). Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell. ANALYST, 143(24), 5912-5917. doi:10.1039/c8an01183d
Submicron infrared imaging of an oesophageal cancer cell with chemical specificity using an IR-FEL
Ingham, J., Craig, T., Smith, C. I., Varro, A., Pritchard, D. M., Barrett, S. D., . . . Siggel-King, M. R. F. (2018). Submicron infrared imaging of an oesophageal cancer cell with chemical specificity using an IR-FEL. Biomedical Physics and Engineering Express, 5. doi:10.1088/2057-1976/aaea53
Stable Isotope Dynamic Labeling of Secretomes (SIDLS) Identifies Authentic Secretory Proteins Released by Cancer and Stromal Cells
Hammond, D. E., Kumar, J. D., Raymond, L., Simpson, D. M., Beynon, R. J., Dockray, G. J., & Varro, A. (2018). Stable Isotope Dynamic Labeling of Secretomes (SIDLS) Identifies Authentic Secretory Proteins Released by Cancer and Stromal Cells. MOLECULAR & CELLULAR PROTEOMICS, 17(9), 1837-1849. doi:10.1074/mcp.TIR117.000516
Matrix metalloproteinase (MMP)-7 in Barrett's esophagus and esophageal adenocarcinoma: expression, metabolism, and functional significance
Garalla, H. M., Lertkowit, N., Tiszlavicz, L., Reisz, Z., Holmberg, C., Beynon, R., . . . Varro, A. (2018). Matrix metalloproteinase (MMP)-7 in Barrett's esophagus and esophageal adenocarcinoma: expression, metabolism, and functional significance. Retrieved from https://www.webofscience.com/
SNOM Imaging of a Crypt-Like Feature in Adenocarcinoma Associated with Barrett's Oesophagus
Craig, T., Smith, A. D., Holder, G. M., Ingham, J., Smith, C. I., Varro, A., . . . Siggel-King, M. R. F. (2018). SNOM Imaging of a Crypt-Like Feature in Adenocarcinoma Associated with Barrett's Oesophagus. PHYSICA STATUS SOLIDI B-BASIC SOLID STATE PHYSICS, 255(4). doi:10.1002/pssb.201700518
An evaluation of the application of the aperture infrared SNOM technique to biomedical imaging
Ingham, J., Pilling, M. J., Craig, T., Siggel-King, M. R. F., Smith, C. I., Gardner, P., . . . Weightman, P. (2018). An evaluation of the application of the aperture infrared SNOM technique to biomedical imaging. Biomedical Physics & Engineering Express, 4(2). doi:10.1088/2057-1976/aaa0de
2017
Comparison Of The Human Gastric Microbiota In Hypochlorhydric States Arising As A Result Of Helicobacter pylori-Induced Atrophic Gastritis, Autoimmune Atrophic Gastritis And Proton Pump Inhibitor Use
parsons, B. N., Ijaz, U. Z., D'Amore, R., Burkitt, M. D., Eccles, R., Lenzi, L., . . . Pritchard, D. M. (2017). Comparison Of The Human Gastric Microbiota In Hypochlorhydric States Arising As A Result Of Helicobacter pylori-Induced Atrophic Gastritis, Autoimmune Atrophic Gastritis And Proton Pump Inhibitor Use. PLoS Pathogens. doi:10.1101/144907
Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use
Parsons, B. N., Ijaz, U. Z., D'Amore, R., Burkitt, M. D., Eccles, R., Lenzi, L., . . . Pritchard, D. M. (2017). Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use. PLoS Pathogens, 13(11). doi:10.1371/journal.ppat.1006653
Cell cycle dependent expression of the CCK2 receptor by gastrointestinal myofibroblasts: putative role in determining cell migration
Varga, A., Kumar, J. D., Simpson, A. W. M., Dodd, S., Hegyi, P., Dockray, G. J., & Varro, A. (2017). Cell cycle dependent expression of the CCK2 receptor by gastrointestinal myofibroblasts: putative role in determining cell migration. PHYSIOLOGICAL REPORTS, 5(19). doi:10.14814/phy2.13394
Glucagon-like petide-2 acts on colon cancer myofibroblasts to stimulate proliferation, migration and invasion of both myofibroblasts and cancer cells via the IGF pathway
Shawe-Taylor, M., Kumar, J. D., Holden, W., Dodd, S., Varga, A., Giger, O., . . . Dockray, G. J. (2017). Glucagon-like petide-2 acts on colon cancer myofibroblasts to stimulate proliferation, migration and invasion of both myofibroblasts and cancer cells via the IGF pathway. PEPTIDES, 91, 49-57. doi:10.1016/j.peptides.2017.03.008
Functional Differentiation of Cholecystokinin-Containing Interneurons Destined for the Cerebral Cortex
Calvigioni, D., Mate, Z., Fuzik, J., Girach, F., Zhang, M. -D., Varro, A., . . . Harkany, T. (2017). Functional Differentiation of Cholecystokinin-Containing Interneurons Destined for the Cerebral Cortex. CEREBRAL CORTEX, 27(4), 2453-2468. doi:10.1093/cercor/bhw094
The development of a framework to personalise hydration management in cancer care: the use of non-invasive technology to evaluate fluid status and dehydration-related symptoms
Nwosu, A. C., mayland, C., mason, S., Benze, G., Nauck, F., Armour, K., . . . Ellershaw, J. (2017). The development of a framework to personalise hydration management in cancer care: the use of non-invasive technology to evaluate fluid status and dehydration-related symptoms. In BMJ Supportive and Palliative Care Vol. Volume 7. Belfast Waterfront: BMJ Publishing Group.
KCTD12 Auxiliary Proteins Modulate Kinetics of GABA(B) Receptor-Mediated Inhibition in CholecystokininContaining Interneurons
Booker, S. A., Althof, D., Gross, A., Loreth, D., Mueller, J., Unger, A., . . . Kulik, A. (2017). KCTD12 Auxiliary Proteins Modulate Kinetics of GABA(B) Receptor-Mediated Inhibition in CholecystokininContaining Interneurons. Cerebral Cortex, 27(3), 2318-2334. doi:10.1093/cercor/bhw090
Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus
Lee, Y., Urbanska, A. M., Hayakawa, Y., Wang, H., Au, A. S., Luna, A. M., . . . Wang, T. C. (2017). Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus. ONCOTARGET, 8(1), 203-214. doi:10.18632/oncotarget.10667
Netazepide, a gastrin/cholecystokinin‐2 receptor antagonist, can eradicate gastric neuroendocrine tumours in patients with autoimmune chronic atrophic gastritis
Boyce, M., Moore, A. R., Sagatun, L., Parsons, B. N., Varro, A., Campbell, F., . . . Pritchard, D. M. (2017). Netazepide, a gastrin/cholecystokinin‐2 receptor antagonist, can eradicate gastric neuroendocrine tumours in patients with autoimmune chronic atrophic gastritis. British Journal of Clinical Pharmacology, 83(3), 466-475. doi:10.1111/bcp.13146
2016
Editorial overview: Gastrointestinal: Gut hormones - from bench to bedside
Dockray, G. J., & Varro, A. (2016). Editorial overview: Gastrointestinal: Gut hormones - from bench to bedside. CURRENT OPINION IN PHARMACOLOGY, 31, V-VI. doi:10.1016/j.coph.2016.09.004
A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies.
Calvete, O., Varro, A., Pritchard, D. M., Barroso, A., Oteo, M., Morcillo, M., . . . Benitez, J. (2016). A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies.. Disease models & mechanisms, 9(9), 975-984. doi:10.1242/dmm.025890
The Association of Hydration Status with Physical Signs, Symptoms and Survival in Advanced Cancer-The Use of Bioelectrical Impedance Vector Analysis (BIVA) Technology to Evaluate Fluid Volume in Palliative Care: An Observational Study
Nwosu, A. C., Mayland, C. R., Mason, S., Cox, T. F., Varro, A., & Ellershaw, J. (2016). The Association of Hydration Status with Physical Signs, Symptoms and Survival in Advanced Cancer-The Use of Bioelectrical Impedance Vector Analysis (BIVA) Technology to Evaluate Fluid Volume in Palliative Care: An Observational Study. PLOS ONE, 11(9). doi:10.1371/journal.pone.0163114
Connective tissue growth factor is activated by gastrin and involved in gastrin-induced migration and invasion
Bhandari, S., Bakke, I., Kumar, J., Beisvag, V., Sandvik, A. K., Thommesen, L., . . . Norsett, K. G. (2016). Connective tissue growth factor is activated by gastrin and involved in gastrin-induced migration and invasion. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 475(1), 119-124. doi:10.1016/j.bbrc.2016.05.052
Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27(kip1)
Lloyd, K. A., Moore, A. R., Parsons, B. N., O'Hara, A., Boyce, M., Dockray, G. J., . . . Pritchard, D. M. (2016). Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27(kip1). ONCOTARGET, 7(29), 45462-45478. doi:10.18632/oncotarget.9990
REGULATION OF MMP-7 EXPRESSION IN THE PROGRESSION TO OESOPHAGEAL ADENOCARCINOMA
Garalla, H. M., Lertkowit, N., Tiszlavicz, L., Reisz, Z., Dockray, G., & Varro, A. (2016). REGULATION OF MMP-7 EXPRESSION IN THE PROGRESSION TO OESOPHAGEAL ADENOCARCINOMA. In GUT Vol. 65 (pp. A130). doi:10.1136/gutjnl-2016-312388.232
The role of chemerin and ChemR23 in stimulating the invasion of squamous oesophageal cancer cells
Kumar, J. D., Kandola, S., Tiszlavicz, L., Reisz, Z., Dockray, G. J., & Varro, A. (2016). The role of chemerin and ChemR23 in stimulating the invasion of squamous oesophageal cancer cells. BRITISH JOURNAL OF CANCER, 114(10), 1152-1159. doi:10.1038/bjc.2016.93
Distinct miRNA profiles in normal and gastric cancer myofibroblasts and significance in Wnt signaling
Wang, L., Steele, I., Kumar, J. D., Dimaline, R., Jithesh, P. V., Tiszlavicz, L., . . . Varro, A. (2016). Distinct miRNA profiles in normal and gastric cancer myofibroblasts and significance in Wnt signaling. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 310(9), G696-G704. doi:10.1152/ajpgi.00443.2015
PAI-1 deficiency increases the trophic effects of hypergastrinemia in the gastric corpus mucosa
Fossmark, R., Rao, S., Mjones, P., Munkvold, B., Flatberg, A., Varro, A., . . . Norsett, K. G. (2016). PAI-1 deficiency increases the trophic effects of hypergastrinemia in the gastric corpus mucosa. PEPTIDES, 79, 83-94. doi:10.1016/j.peptides.2016.03.016
A knockin mouse with a missense mutation in the H/K-ATPase ATP4a gene, mimics an aggressive familial form of gastric type I neuroendocrine tumors in humans. Assessment of new therapeutic strategies
Calvete, O., Vargiu, P., Varro, A., Oteo, M., Morcillo, M. A., Barroso, A., . . . Ortega, S. (2016). A knockin mouse with a missense mutation in the H/K-ATPase ATP4a gene, mimics an aggressive familial form of gastric type I neuroendocrine tumors in humans. Assessment of new therapeutic strategies. TRANSGENIC RESEARCH, 25(2), 253-254. Retrieved from https://www.webofscience.com/
Netazepide, a Gastrin/CCK2 Receptor Antagonist, Can Eradicate Gastric Neuroendocrine Tumours in Patients with Autoimmune Chronic Atrophic Gastritis
Boyce, M., Moore, A. R., Parsons, B. N., Lloyd, K. A., Sagatun, L., Thomsen, L., . . . Pritchard, D. M. (2016). Netazepide, a Gastrin/CCK2 Receptor Antagonist, Can Eradicate Gastric Neuroendocrine Tumours in Patients with Autoimmune Chronic Atrophic Gastritis. In NEUROENDOCRINOLOGY Vol. 103 (pp. 78). Retrieved from https://www.webofscience.com/
2015
Mesenchymal Stem Cells Exhibit Regulated Exocytosis in Response to Chemerin and IGF
Kumar, J., Holmberg, C., Balabanova, S., Borysova, L., Burdyga, T., Beynon, R., . . . Varro, A. (2015). Mesenchymal Stem Cells Exhibit Regulated Exocytosis in Response to Chemerin and IGF. PLOS ONE, 10(10). doi:10.1371/journal.pone.0141331
Helicobacter pylori, HIV and Gastric Hypochlorhydria in the Malawian Population
Geraghty, J., Thumbs, A., Kankwatira, A., Andrews, T., Moore, A., Malamba, R., . . . Gordon, M. (2015). Helicobacter pylori, HIV and Gastric Hypochlorhydria in the Malawian Population. PloS One, 10(8). doi:10.1371/journal.pone.0132043
Gastrin stimulates MMP-1 expression in gastric epithelial cells: putative role in gastric epithelial cell migration
Kumar, J. D., Steele, I., Moore, A. R., Murugesan, S. V., Rakonczay, Z., Venglovecz, V., . . . Dockray, G. J. (2015). Gastrin stimulates MMP-1 expression in gastric epithelial cells: putative role in gastric epithelial cell migration. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 309(2), G78-G86. doi:10.1152/ajpgi.00084.2015
HELICOBACTER PYLORI, HIV AND GASTRIC HYPOCHLORHYDRIA IN THE MALAWIAN POPULATION
Geraghty, J., Thumbs, A., Kankwatira, A., Andrews, T., Moore, A., Malamba, R., . . . Gordon, M. (2015). HELICOBACTER PYLORI, HIV AND GASTRIC HYPOCHLORHYDRIA IN THE MALAWIAN POPULATION. In GUT Vol. 64 (pp. A295). doi:10.1136/gutjnl-2015-309861.636
Su1978 Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy
O'Hara, A., Burkitt, M. D., Carr, D. F., Alfirevic, A., Moore, A. R., Murugesan, S. V., . . . Pritchard, D. M. (2015). Su1978 Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy. Gastroenterology, 148(4), S-566. doi:10.1016/s0016-5085(15)31907-7
A Combination of Fasting Serum Gastrin Concentration, Pepsinogen 1/2 Ratio and <i>Helicobacter pylori</i> IgG Antibody Serotype Accurately Predicts Gastric Mucosal Preneoplasia in a Large European Cohort
Moore, A. R., Steele, I., Murugesan, S. V., Tiszlavicz, L., Dockray, G. J., Varro, A., & Pritchard, D. M. (2015). A Combination of Fasting Serum Gastrin Concentration, Pepsinogen 1/2 Ratio and <i>Helicobacter pylori</i> IgG Antibody Serotype Accurately Predicts Gastric Mucosal Preneoplasia in a Large European Cohort. In GASTROENTEROLOGY Vol. 148 (pp. S54). Retrieved from https://www.webofscience.com/
Gastrin Increases miR-222 Expression in AGS<sub>GR</sub> Cells <i>In Vitro</i> and in the Stomachs of Hypergastrinemic INS-GAS Mice and Humans <i>In Vivo</i> via Activation of the CCK2 Receptor
Lloyd, K. A., Moore, A. R., O'Hara, A., Boyce, M. J., Varro, A., & Pritchard, D. M. (2015). Gastrin Increases miR-222 Expression in AGS<sub>GR</sub> Cells <i>In Vitro</i> and in the Stomachs of Hypergastrinemic INS-GAS Mice and Humans <i>In Vivo</i> via Activation of the CCK2 Receptor. In GASTROENTEROLOGY Vol. 148 (pp. S341). Retrieved from https://www.webofscience.com/
Global hypomethylation of esophageal myofibroblasts is associated with accelerated tumor growth.
Giger, O. T., Brown, B., Liloglou, T., Jithesh, P. V., Dockray, J. G., & Varro, A. (2015). Global hypomethylation of esophageal myofibroblasts is associated with accelerated tumor growth.. In CANCER RESEARCH Vol. 75. doi:10.1158/1538-7445.CHTME14-B20
Identification of Potential Biomarkers of Netazepide (YF476) Treatment of Type I Gastric Neuroendocrine Tumours
Moore, A. R., Parsons, B. N., Boyce, M. J., Rainbow, L., Fang, Y., Varro, A., . . . Pritchard, D. M. (2015). Identification of Potential Biomarkers of Netazepide (YF476) Treatment of Type I Gastric Neuroendocrine Tumours. In GASTROENTEROLOGY Vol. 148 (pp. S342). Retrieved from https://www.webofscience.com/
Polymorphisms in the <i>RELB</i> Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy
O'Hara, A., Burkitt, M. D., Carr, D. F., Alfirevic, A., Moore, A. R., Murugesan, S. V., . . . Pritchard, D. M. (2015). Polymorphisms in the <i>RELB</i> Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy. In GASTROENTEROLOGY Vol. 148 (pp. S566). Retrieved from https://www.webofscience.com/
2014
Analysis of Clinical Isolates of Helicobacter pylori in Pakistan Reveals High Degrees of Pathogenicity and High Frequencies of Antibiotic Resistance
Rasheed, F., Campbell, B. J., Alfizah, H., Varro, A., Zahra, R., Yamaoka, Y., & Pritchard, D. M. (2014). Analysis of Clinical Isolates of Helicobacter pylori in Pakistan Reveals High Degrees of Pathogenicity and High Frequencies of Antibiotic Resistance. Helicobacter, 19(5), 387-399. doi:10.1111/hel.12142
Increased expression of chemerin in squamous esophageal cancer myofibroblasts and role in recruitment of mesenchymal stromal cells
Kumar, J. D., Holmberg, C., Kandola, S., Steele, I., Hegyi, P., Tiszlavicz, L., . . . Varro, A. (2014). Increased expression of chemerin in squamous esophageal cancer myofibroblasts and role in recruitment of mesenchymal stromal cells. PLoS One, 9(8). doi:10.1371/journal.pone.0104877
The neuroendocrine phenotype of gastric myofibroblasts and its loss with cancer progression
Balabanova, S., Holmberg, C., Steele, I., Ebrahimi, B., Rainbow, L., Burdyga, T., . . . Varro, A. (2014). The neuroendocrine phenotype of gastric myofibroblasts and its loss with cancer progression. Carcinogenesis, 35(8), 1798-1806. doi:10.1093/carcin/bgu086
Novel roles of gastrin
Dimaline, R., & Varro, A. (2014). Novel roles of gastrin. JOURNAL OF PHYSIOLOGY-LONDON, 592(14), 2951-2958. doi:10.1113/jphysiol.2014.272435
OC-018 Gastrin Increases Mir-222 Expression In Gastric Epithelial Cells in Vitro And Hypergastrinaemic Ins-gas Mice In Vivo
Lloyd, K., O'Hara, A., Varro, A., & Pritchard, D. M. (2014). OC-018 Gastrin Increases Mir-222 Expression In Gastric Epithelial Cells in Vitro And Hypergastrinaemic Ins-gas Mice In Vivo. Gut, 63, A9. doi:10.1136/gutjnl-2014-307263.18
Indian Hedgehog Mediates Gastrin-Induced Proliferation in Stomach of Adult Mice
Feng, R., Aihara, E., Kenny, S., Yang, L., Li, J., Varro, A., . . . Zavros, Y. (2014). Indian Hedgehog Mediates Gastrin-Induced Proliferation in Stomach of Adult Mice. Gastroenterology, 147(3), 655-666.e9. doi:10.1053/j.gastro.2014.05.006
2013
Signaling mediated by the NF-κB sub-units NF-κB1, NF-κB2 and c-Rel differentially regulate <i>Helicobacter felis</i>-induced gastric carcinogenesis in C57BL/6 mice
Burkitt, M. D., Williams, J. M., Duckworth, C. A., O'Hara, A., Hanedi, A., Varro, A., . . . Pritchard, D. M. (2013). Signaling mediated by the NF-κB sub-units NF-κB1, NF-κB2 and c-Rel differentially regulate <i>Helicobacter felis</i>-induced gastric carcinogenesis in C57BL/6 mice. ONCOGENE, 32(50), 5563-5573. doi:10.1038/onc.2013.334
Netazepide, a Gastrin Receptor Antagonist, Normalises Tumour Biomarkers and Causes Regression of Type 1 Gastric Neuroendocrine Tumours in a Nonrandomised Trial of Patients with Chronic Atrophic Gastritis
Moore, A. R., Boyce, M., Steele, I. A., Campbell, F., Varro, A., & Pritchard, D. M. (2013). Netazepide, a Gastrin Receptor Antagonist, Normalises Tumour Biomarkers and Causes Regression of Type 1 Gastric Neuroendocrine Tumours in a Nonrandomised Trial of Patients with Chronic Atrophic Gastritis. PLOS ONE, 8(10). doi:10.1371/journal.pone.0076462
Mapping proteolytic processing in the secretome of gastric cancer-associated myofibroblasts reveals activation of MMP-1, MMP-2, and MMP-3.
Holmberg, C., Ghesquière, B., Impens, F., Gevaert, K., Kumar, J. D., Cash, N., . . . Varro, A. (2013). Mapping proteolytic processing in the secretome of gastric cancer-associated myofibroblasts reveals activation of MMP-1, MMP-2, and MMP-3.. Journal of proteome research, 12(7), 3413-3422. doi:10.1021/pr400270q
Sa1735 Proteasome Beta Subunits Interact With the PAI-2 and Regi Promoters and Are Required for Gastrin-Stimulated Transcription
O'Hara, A., Howarth, A. E., Varro, A., & Dimaline, R. (2013). Sa1735 Proteasome Beta Subunits Interact With the PAI-2 and Regi Promoters and Are Required for Gastrin-Stimulated Transcription. Gastroenterology, 144(5), S-295. doi:10.1016/s0016-5085(13)61047-1
The role of proteasome beta subunits in gastrin-mediated transcription of plasminogen activator inhibitor-2 and regenerating protein1.
O'Hara, A., Howarth, A., Varro, A., & Dimaline, R. (2013). The role of proteasome beta subunits in gastrin-mediated transcription of plasminogen activator inhibitor-2 and regenerating protein1.. PloS one, 8(3), e59913. doi:10.1371/journal.pone.0059913
Gastric Expression of Plasminogen Activator Inhibitor (PAI)-1 Is Associated with Hyperphagia and Obesity in Mice
Kenny, S., Gamble, J., Lyons, S., Vlatkovic, N., Dimaline, R., Varro, A., & Dockray, G. J. (2013). Gastric Expression of Plasminogen Activator Inhibitor (PAI)-1 Is Associated with Hyperphagia and Obesity in Mice. ENDOCRINOLOGY, 154(2), 718-726. doi:10.1210/en.2012-1913
Hydration in Advanced Cancer: Can Bioelectrical Impedance Analysis Improve the Evidence Base? A Systematic Review of the Literature
Nwosu, A. C., Mayland, C. R., Mason, S. R., Khodabukus, A. F., Varro, A., & Ellershaw, J. E. (2013). Hydration in Advanced Cancer: Can Bioelectrical Impedance Analysis Improve the Evidence Base? A Systematic Review of the Literature. JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 46(3), 433-+. doi:10.1016/j.jpainsymman.2012.08.018
Patients want to be involved in end-of-life care research
Nwosu, A. C., Mayland, C. R., Mason, S., Varro, A., & Ellershaw, J. E. (2013). Patients want to be involved in end-of-life care research. BMJ Support Palliat Care.
Patients want to be involved in end-of-life care research.
Nwosu, A. C., Mayland, C. R., Mason, S., Varro, A., & Ellershaw, J. E. (2013). Patients want to be involved in end-of-life care research.. BMJ supportive & palliative care, 3(4), 457. doi:10.1136/bmjspcare-2013-000537
Progastrin-Induced Secretion of Insulin-Like Growth Factor 2 From Colonic Myofibroblasts Stimulates Colonic Epithelial Proliferation in Mice
Duckworth, C. A., Clyde, D., Worthley, D. L., Wang, T. C., Varro, A., & Pritchard, D. M. (2013). Progastrin-Induced Secretion of Insulin-Like Growth Factor 2 From Colonic Myofibroblasts Stimulates Colonic Epithelial Proliferation in Mice. GASTROENTEROLOGY, 145(1), 197-+. doi:10.1053/j.gastro.2013.03.012
2012
Release of TGFβig-h3 by gastric myofibroblasts slows tumor growth and is decreased with cancer progression.
Holmberg, C., Quante, M., Steele, I., Kumar, J. D., Balabanova, S., Duval, C., . . . Varro, A. (2012). Release of TGFβig-h3 by gastric myofibroblasts slows tumor growth and is decreased with cancer progression.. Carcinogenesis, 33(8), 1553-1562. doi:10.1093/carcin/bgs180
NHE1 activity contributes to migration and is necessary for proliferation of human gastric myofibroblasts.
Czepán, M., Rakonczay, Z., Varró, A., Steele, I., Dimaline, R., Lertkowit, N., . . . Hegyi, P. (2012). NHE1 activity contributes to migration and is necessary for proliferation of human gastric myofibroblasts.. Pflugers Archiv : European journal of physiology, 463(3), 459-475. doi:10.1007/s00424-011-1059-6
Gastric Sonic Hedgehog acts as a macrophage chemoattractant during the immune response to Helicobacter pylori
Schumacher, M. A., Donnelly, J. M., Engevik, A. C., Xiao,, C., Yang, L., Kenny, S., . . . Zavros, Y. (2012). Gastric Sonic Hedgehog acts as a macrophage chemoattractant during the immune response to Helicobacter pylori. Gastroenterology, 142(5), 1150-1159.
Inhibitors of acid secretion can benefit gastric wound repair independent of luminal pH effects on the site of damage
Demitrack, E. S., Aihara, E., Kenny, S., Varro, A., & Montrose, M. H. (2012). Inhibitors of acid secretion can benefit gastric wound repair independent of luminal pH effects on the site of damage.
2011
CLASSICAL AND ALTERNATIVE PATHWAY NF-KB SIGNALLING REGULATE GASTRIC EPITHELIAL RESPONSES TO GAMMA-IRRADIATION
Burkitt, M. D., Duckworth, C. A., Varro, A., Caamano, J. H., & Pritchard, D. M. (2011). CLASSICAL AND ALTERNATIVE PATHWAY NF-KB SIGNALLING REGULATE GASTRIC EPITHELIAL RESPONSES TO GAMMA-IRRADIATION. GUT, 60, A9. doi:10.1136/gut.2011.239301.17
Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth.
Quante, M., Tu, S. P., Tomita, H., Gonda, T., Wang, S. S. W., Takashi, S., . . . Wang, T. C. (2011). Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth.. Cancer cell, 19(2), 257-272. doi:10.1016/j.ccr.2011.01.020
Classical and Alternative Pathway Nuclear Factor-κB Signalling Regulate Gastric Epithelial Responses to γ-Irradiation
Burkitt, M. D., Duckworth, C. A., Varro, A., Caamano, J., & Pritchard, D. M. (2011). Classical and Alternative Pathway Nuclear Factor-κB Signalling Regulate Gastric Epithelial Responses to γ-Irradiation. GASTROENTEROLOGY, 140(5), S823. Retrieved from https://www.webofscience.com/
Gastrin stimulates expression of plasminogen activator inhibitor (PAI)-1 in gastric epithelial cells
Norsett, K. G., Steele, I., Duval, C., Sammut, S. J., Murugesan, S. V., Kenny, S., . . . Varro, A. (2011). Gastrin stimulates expression of plasminogen activator inhibitor (PAI)-1 in gastric epithelial cells. American Journal of Physiology, Gastrointestinal Liver Physiology, 301, G446-G453.
Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing
Tomita, H., Takaishi, S., Menheniott, T. R., Yang, X., Shibata, W., Jin, G., . . . Wang, T. C. (2011). Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing.
Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia
Lofgren, J. L., Whary, M. T., Ge, Z., Muthupalani, S., Taylor, N. S., Mobley, M., . . . Fox, J. G. (2011). Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia.
Progastrin stimulates colonic myofibroblast proliferation in vitro and its transgenic over-expression increases colonic myofibroblast abundance in vivo
Clyde, D., Duckworth, C. A., Varro, A., Wang, T. C., & Pritchard, D. M. (2011). Progastrin stimulates colonic myofibroblast proliferation in vitro and its transgenic over-expression increases colonic myofibroblast abundance in vivo. Gastroenterology, 140(5), S106.
2010
EGR1 Is a target for cooperative interactions between cholecystokinin and leptin, and inhibition by ghrelin, in vagal afferent neurons.
de Lartigue, G., Lur, G., Dimaline, R., Varro, A., Raybould, H., & Dockray, G. J. (2010). EGR1 Is a target for cooperative interactions between cholecystokinin and leptin, and inhibition by ghrelin, in vagal afferent neurons.. Endocrinology, 151(8), 3589-3599. doi:10.1210/en.2010-0106
Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype.
Burdyga, G., Varro, A., Dimaline, R., Thompson, D. G., & Dockray, G. J. (2010). Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype.. American journal of physiology. Gastrointestinal and liver physiology, 299(1), G63-G69. doi:10.1152/ajpgi.00059.2010
Cocaine- and Amphetamine-Regulated Transcript Mediates the Actions of Cholecystokinin on Rat Vagal Afferent Neurons
De Lartigue, G., Dimaline, R., Varro, A., Raybould, H., De La Serre, C. B., & Dockray, G. J. (2010). Cocaine- and Amphetamine-Regulated Transcript Mediates the Actions of Cholecystokinin on Rat Vagal Afferent Neurons. Gastroenterology, 138(4), 1479-1490. doi:10.1053/j.gastro.2009.10.034
Cocaine- and amphetamine-regulated transcript mediates the actions of cholecystokinin on rat vagal afferent neurons.
De Lartigue, G., Dimaline, R., Varro, A., Raybould, H., De la Serre, C. B., & Dockray, G. J. (2010). Cocaine- and amphetamine-regulated transcript mediates the actions of cholecystokinin on rat vagal afferent neurons.. Gastroenterology, 138(4), 1479-1490. doi:10.1053/j.gastro.2009.10.034
Defining the role of cholecystokinin in the lipid-induced human brain activation matrix.
Lassman, D. J., McKie, S., Gregory, L. J., Lal, S., D'Amato, M., Steele, I., . . . Thompson, D. G. (2010). Defining the role of cholecystokinin in the lipid-induced human brain activation matrix.. Gastroenterology, 138(4), 1514-1524. doi:10.1053/j.gastro.2009.12.060
EGR1 Is a target for cooperative interactions between cholecystokinin and leptin, and inhibition by ghrelin, in vagal afferent neurons.
de Lartigue, G., Lur, G., Dimaline, R., Varro, A., Raybould, H., & Dockray, G. J. (2010). EGR1 Is a target for cooperative interactions between cholecystokinin and leptin, and inhibition by ghrelin, in vagal afferent neurons.. Endocrinology, 151(8), 3589-3599.
Elevated serum gastrin is associated with a history of advanced neoplasia in Barrett's esophagus.
Wang, J. S., Varro, A., Lightdale, C. J., Lertkowit, N., Slack, K. N., Fingerhood, M. L., . . . Abrams, J. A. (2010). Elevated serum gastrin is associated with a history of advanced neoplasia in Barrett's esophagus.. Am J Gastroenterol., 105(5), 1039-1045.
Gastrin stimulates expression of plasminogen activator inhibitor (PAI)-1 in gastric epithelial cells.
Norsett, K. G., Steele, I., Duval, C., Sammut, S. J., Murugesan, S. V., Kenny, S., . . . Varro, A. (2010). Gastrin stimulates expression of plasminogen activator inhibitor (PAI)-1 in gastric epithelial cells.. Am J Physiol Gastrointest Liver Physiol..
Inhibition of Gastric Carcinogenesis by the Hormone Gastrin Is Mediated by Suppression of TFF1 Epigenetic Silencing.
Tomita, H., Takaishi, S., Menheniott, T. R., Yang, X., Shibata, W., Jin, G., . . . Wang, T. C. (2010). Inhibition of Gastric Carcinogenesis by the Hormone Gastrin Is Mediated by Suppression of TFF1 Epigenetic Silencing.. Gastroenterology.
Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia.
Lofgren, J. L., Whary, M. T., Ge, Z., Muthupalani, S., Taylor, N. S., Mobley, M., . . . Fox, J. G. (2010). Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia.. Gastroenterology, 140(1), 210-220.
Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells
Xiao, C., Ogle, S. A., Schumacher, M. A., Orr-Asman, M. A., Miller, M. L., Lertkowit, N., . . . Zavros, Y. (2010). Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells.
Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells.
Xiao, C., Ogle, S. A., Schumacher, M. A., Orr-Asman, M. A., Miller, M. L., Lertkowit, N., . . . Zavros, Y. (2010). Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells.. Gastroenterology, 138(2), 5500-5561.
Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy?
Gonda, T. A., Varro, A., Wang, T. C., & Tycko, B. (2010). Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy?. Semin Cell Dev Biol., 21(1), 2-10.
Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy?
Gonda, T. A., Varro, A., Wang, T. C., & Tycko, B. (2010). Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy?.
2009
Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1.
Almeida-Vega, S., Catlow, K., Kenny, S., Dimaline, R., & Varro, A. (2009). Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1.. American journal of physiology. Gastrointestinal and liver physiology, 296(2), G414-G423. doi:10.1152/ajpgi.90340.2008
Importance of gastrin in the pathogenesis and treatment of gastric tumors
Burkitt, M. D., Varro, A., & Pritchard, D. M. (2009). Importance of gastrin in the pathogenesis and treatment of gastric tumors. WORLD JOURNAL OF GASTROENTEROLOGY, 15(1), 1-16. doi:10.3748/wjg.15.1
2008
Global hypomethylation of genomic DNA in cancer-associated myofibroblasts.
Jiang, L., Gonda, T. A., Gamble, M. V., Salas, M., Seshan, V., Tu, S., . . . Tycko, B. (2008). Global hypomethylation of genomic DNA in cancer-associated myofibroblasts.. Cancer research, 68(23), 9900-9908. doi:10.1158/0008-5472.can-08-1319
Cholecystokinin regulates expression of Y2 receptors in vagal afferent neurons serving the stomach.
Burdyga, G., de Lartigue, G., Raybould, H. E., Morris, R., Dimaline, R., Varro, A., . . . Dockray, G. J. (2008). Cholecystokinin regulates expression of Y2 receptors in vagal afferent neurons serving the stomach.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(45), 11583-11592. doi:10.1523/jneurosci.2493-08.2008
Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor
Pritchard, D. M., Berry, D., Przemeck, S. M. C., Campbell, F., Edwards, S. W., & Varro, A. (2008). Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 295(4), G798-G805. doi:10.1152/ajpgi.00015.2008
Increased expression of the urokinase plasminogen activator system by <i>Helicobacter pylori</i> in gastric epithelial cells
Kenny, S., Duval, C., Sammut, S. J., Steele, I., Pritchard, D. M., Atherton, J. C., . . . Varro, A. (2008). Increased expression of the urokinase plasminogen activator system by <i>Helicobacter pylori</i> in gastric epithelial cells. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 295(3), G431-G441. doi:10.1152/ajpgi.90283.2008
Hypergastrinemia increases gastric epithelial susceptibility to apoptosis
Przemeck, S. M. C., Varro, A., Berry, D., Steele, I., Wang, T. C., Dockray, G. J., & Pritchard, D. M. (2008). Hypergastrinemia increases gastric epithelial susceptibility to apoptosis. Regulatory Peptides, 146(1-3), 147-156. doi:10.1016/j.regpep.2007.09.002
Hypergastrinemia increases gastric epithelial susceptibility to apoptosis
Przemeck, S. M. C., Varro, A., Berry, D., Steele, I., Wang, T. C., Dockray, G. J., & Pritchard, D. M. (2008). Hypergastrinemia increases gastric epithelial susceptibility to apoptosis. REGULATORY PEPTIDES, 146(1-3), 147-156. doi:10.1016/j.regpep.2007.09.002
Regulation of mammalian gastrin/CCK receptor (CCK2R) expression in vitro and in vivo.
Ashurst, H. L., Varro, A., & Dimaline, R. (2008). Regulation of mammalian gastrin/CCK receptor (CCK2R) expression in vitro and in vivo.. Experimental physiology, 93(2), 223-236. doi:10.1113/expphysiol.2007.040683
Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine <i>Helicobacter</i> infection
Bodger, K., Ahmed, S., Pazmany, L., Pritchard, D. M., Micheal, A., Khan, A. L., . . . Varro, A. (2008). Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine <i>Helicobacter</i> infection. JOURNAL OF CLINICAL PATHOLOGY, 61(1), 72-78. doi:10.1136/jcp.2007.048058
Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine<i>Helicobacter</i>infection
Bodger, K., Ahmed, S., Pazmany, L., Pritchard, D. M., Micheal, A., Khan, A. L., . . . Varro, A. (2008). Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine<i>Helicobacter</i>infection. Journal of Clinical Pathology, 61(1), 72-78. doi:10.1136/jcp.2007.048058
Identification of ezrin as a target of gastrin in immature mouse gastric parietal cells
Pagliocca, A., Hegyi, P., Venglovecz, V., Rackstraw, S. A., Khan, Z., Burdyga, G., . . . Dockray, G. J. (2008). Identification of ezrin as a target of gastrin in immature mouse gastric parietal cells. EXPERIMENTAL PHYSIOLOGY, 93(11), 1174-1189. doi:10.1113/expphysiol.2008.042648
2007
Neurologic, gastric, and opthalmologic pathologies in a murine model of mucolipidosis type IV.
Venugopal, B., Browning, M. F., Curcio-Morelli, C., Varro, A., Michaud, N., Nanthakumar, N., . . . Slaugenhaupt, S. A. (2007). Neurologic, gastric, and opthalmologic pathologies in a murine model of mucolipidosis type IV.. American journal of human genetics, 81(5), 1070-1083. doi:10.1086/521954
Carcinogenic hypergastrinemia: Signet-ring cell carcinoma in a patient with multiple endocrine neoplasia type 1 with Zollinger-Ellison's syndrome
Schott, M., Sagert, C., Willenberg, H. S., Schinner, S., Ramp, U., Varro, A., . . . Scherbaum, W. A. (2007). Carcinogenic hypergastrinemia: Signet-ring cell carcinoma in a patient with multiple endocrine neoplasia type 1 with Zollinger-Ellison's syndrome. Journal of Clinical Endocrinology and Metabolism, 92(9), 3378-3382. doi:10.1210/jc.2007.0283
<i>Helicobacter</i> and gastrin stimulate Reg1 expression in gastric epithelial cells through distinct promoter elements
Steele, I. A., Dimaline, R., Pritchard, D. M., Peek, R. M. J., Wang, T. C., Dockray, G. J., & Varro, A. (2007). <i>Helicobacter</i> and gastrin stimulate Reg1 expression in gastric epithelial cells through distinct promoter elements. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 293(1), G347-G354. doi:10.1152/ajpgi.00076.2007
Attack and defence in the gastric epithelium - a delicate balance.
Dimaline, R., & Varro, A. (2007). Attack and defence in the gastric epithelium - a delicate balance.. Experimental physiology, 92(4), 591-601. doi:10.1113/expphysiol.2006.036483
Identification of a gastrin response element in the vesicular monoamine transporter type 2 promoter and requirement of 20 S proteasome subunits for transcriptional activity.
Catlow, K., Ashurst, H. L., Varro, A., & Dimaline, R. (2007). Identification of a gastrin response element in the vesicular monoamine transporter type 2 promoter and requirement of 20 S proteasome subunits for transcriptional activity.. The Journal of biological chemistry, 282(23), 17069-17077. doi:10.1074/jbc.m611421200
Potentiation of oxyntic atrophy-induced gastric metaplasia in amphiregulin-deficient mice.
Nam, K. T., Varro, A., Coffey, R. J., & Goldenring, J. R. (2007). Potentiation of oxyntic atrophy-induced gastric metaplasia in amphiregulin-deficient mice.. Gastroenterology, 132(5), 1804-1819. doi:10.1053/j.gastro.2007.03.040
Increased gastric expression of MMP-7 in hypergastrinemia and significance for epithelial-mesenchymal signaling
Varro, A., Kenny, S., Hemers, E., McCaig, C., Przemeck, S., Wang, T. C., . . . Pritchard, D. M. (2007). Increased gastric expression of MMP-7 in hypergastrinemia and significance for epithelial-mesenchymal signaling. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 292(4), G1133-G1140. doi:10.1152/ajpgi.00526.2006
Cocaine- and amphetamine-regulated transcript: stimulation of expression in rat vagal afferent neurons by cholecystokinin and suppression by ghrelin.
de Lartigue, G., Dimaline, R., Varro, A., & Dockray, G. J. (2007). Cocaine- and amphetamine-regulated transcript: stimulation of expression in rat vagal afferent neurons by cholecystokinin and suppression by ghrelin.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(11), 2876-2882. doi:10.1523/jneurosci.5508-06.2007
'GAST gene expression is upregulated in non-small cell lung cancer
Liloglou, T., Daskalos, A., Xinarianos, G., Nikolaidis, G., Varro, A., & Field, J. K. (2007). 'GAST gene expression is upregulated in non-small cell lung cancer. In National Cancer Research Institute Conference (pp. 86). Birmingham: National Cancer Research Institute.
Functional Regulation of ECL cells
Varro, A., Kenny, S., Pritchards, D. M., McCaig, C., & Dockray, G. J. (2007). Functional Regulation of ECL cells. In E. Modlin (Ed.), A Centery Advances in Neuroedocrine Disease:a Tribute to Siegfried Oberdorfen (pp. 172-177). Cambridge, UK: Cambridge University Press.
Post-translational Processing: Peptide Hormones and Neuropeptide Transmitters
Varro, A. (2007). Post-translational Processing: Peptide Hormones and Neuropeptide Transmitters. In Y. Zheng (Ed.), Encylopedia of Life Scieces (pp. 1-5). Hoboken: John Wiley &Sons.
2006
Altered metaplastic response of waved-2 EGF receptor mutant mice to acute oxyntic atrophy
Ogawa, M., Nomura, S., Varro, A., Wang, T. C., & Goldenring, J. R. (2006). Altered metaplastic response of waved-2 EGF receptor mutant mice to acute oxyntic atrophy. Am JPhysiol Gastrointest Liver Physiol.
Feeding-dependent depression of melanin-concentrating hormone and melanin-concentrating hormone receptor-1 expression in vagal afferent neurones.
Burdyga, G., Varro, A., Dimaline, R., Thompson, D. G., & Dockray, G. J. (2006). Feeding-dependent depression of melanin-concentrating hormone and melanin-concentrating hormone receptor-1 expression in vagal afferent neurones.. Neuroscience, 137(4), 1405-1415. doi:10.1016/j.neuroscience.2005.10.057
Gastrin and members of the bcl-2 family regulate gastric epithelial apoptosis in vivo
Przemeck, S., Duckworth, C. A., Varro, A., Pritchard, D., & Pritchard, M. (2006). Gastrin and members of the bcl-2 family regulate gastric epithelial apoptosis in vivo. GUT, 55, A61. Retrieved from https://www.webofscience.com/
Gastrin increases murine intestinal crypt regeneration following injury
Ottewell, P. D., Duckworth, C. A., Varro, A., Dimaline, R., Wang, T. C., Watson, A. J. M., . . . Pritchard, D. M. (2006). Gastrin increases murine intestinal crypt regeneration following injury. GASTROENTEROLOGY, 130(4), 1169-1180. doi:10.1053/j.gastro.2005.12.033
Ghrelin receptors in rat and human nodose ganglia: putative role in regulating cannabinoid (CB-1) and melanin concentrating hormone (MCH-1) receptor abundance
Burdyga, G., Varro, A., Dimaline, R., Thompson, D. G., & Dockray, G. J. (2006). Ghrelin receptors in rat and human nodose ganglia: putative role in regulating cannabinoid (CB-1) and melanin concentrating hormone (MCH-1) receptor abundance. Am J Physiol Gastrointest Liver Physiol. Retrieved from http://www.ncbi.nlm.nih.gov/
The role of matrix metalloproteinase-7 in redefining the gastric microenvironment in response to <i>Helicobacter pylori</i>
McCaig, C., Duval, C., Hemers, E., Steele, I., Pritchard, D. M., Przemeck, S., . . . Varro, A. (2006). The role of matrix metalloproteinase-7 in redefining the gastric microenvironment in response to <i>Helicobacter pylori</i>. GASTROENTEROLOGY, 130(6), 1754-1763. doi:10.1053/j.gastro.2006.02.031
2005
Insulin-like growth factor binding protein-5 is a target of matrix metalloproteinase-7: implications for epithelial-mesenchymal signaling.
Hemers, E., Duval, C., McCaig, C., Handley, M., Dockray, G. J., & Varro, A. (2005). Insulin-like growth factor binding protein-5 is a target of matrix metalloproteinase-7: implications for epithelial-mesenchymal signaling.. Cancer research, 65(16), 7363-7369. doi:10.1158/0008-5472.can-05-0157
Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer.
Takaishi, S., Cui, G., Frederick, D. M., Carlson, J. E., Houghton, J., Varro, A., . . . Wang, T. C. (2005). Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer.. Gastroenterology, 128(7), 1965-1983. doi:10.1053/j.gastro.2005.03.027
COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivo
Ottewell, P. D., Varro, A., Dockray, G. J., Kirton, C. M., Watson, A. J. M., Wang, T. C., . . . Pritchard, D. M. (2005). COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivo. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 288(3), G541-G549. doi:10.1152/ajpgi.00268.2004
Gastrin induces MDM-2 and suppresses p53 expression in AGS<sub>GR</sub> cells, resulting in resistance to DNA damage induced apoptosis
Przemeck, S. M. C., Watson, A. J., Varro, A., & Pritchard, D. M. (2005). Gastrin induces MDM-2 and suppresses p53 expression in AGS<sub>GR</sub> cells, resulting in resistance to DNA damage induced apoptosis. GUT, 54, A87-A88. Retrieved from https://www.webofscience.com/
Gastrin induces mdm-2 and suppresses p53 protein expression in Ags-GR cells, resulting in resistance to DNA damage induced apoptosis
Przemeck, S. M., Watson, A. J., Varro, A., & Pritichard, D. M. (2005). Gastrin induces mdm-2 and suppresses p53 protein expression in Ags-GR cells, resulting in resistance to DNA damage induced apoptosis. Gastroenterology, 128(4 Supp), A-141.
Gastrin: old hormone, new functions.
Dockray, G., Dimaline, R., & Varro, A. (2005). Gastrin: old hormone, new functions.. Pflugers Archiv : European journal of physiology, 449(4), 344-355. doi:10.1007/s00424-004-1347-5
Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced intestinal mucositis in mice.
Duckworth, C. A., Ottewell, P. D., Varro, A., Dimaline, R., & Pritchard, D. M. (2005). Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced intestinal mucositis in mice.. GASTROENTEROLOGY, 128(4), A203. Retrieved from https://www.webofscience.com/
Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced mucositis in mice
Duckworth, C. A., Ottewell, P. D., Dimaline, R., Varro, A., & Pritchard, D. M. (2005). Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced mucositis in mice. GUT, 54, A98. Retrieved from https://www.webofscience.com/
Radiation induces gastrin-CCK<sub>B</sub> receptor expression in IEC-6 and IEC-18 intestinal epithelial cells
Ottewell, P. D., Watson, A. J., Varro, A., & Pritchard, D. M. (2005). Radiation induces gastrin-CCK<sub>B</sub> receptor expression in IEC-6 and IEC-18 intestinal epithelial cells. GUT, 54, A88. Retrieved from https://www.webofscience.com/
Th1 cytokines, but not gastrin increase <i>Helicobacter pylori</i> induced apoptosis in short term primary cultures of murine gastric glands
Przemeck, M. C., Watson, A. J., Varro, A., & Pritchard, D. M. (2005). Th1 cytokines, but not gastrin increase <i>Helicobacter pylori</i> induced apoptosis in short term primary cultures of murine gastric glands. GUT, 54, A61. Retrieved from https://www.webofscience.com/
2004
Overexpression of glycine-extended gastrin inhibits parietal cell loss and atrophy in the mouse stomach.
Cui, G., Koh, T. J., Chen, D., Zhao, C. -M., Takaishi, S., Dockray, G. J., . . . Wang, T. C. (2004). Overexpression of glycine-extended gastrin inhibits parietal cell loss and atrophy in the mouse stomach.. Cancer research, 64(22), 8160-8166. doi:10.1158/0008-5472.can-04-0876
Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element.
Ashcroft, F. J., Varro, A., Dimaline, R., & Dockray, G. J. (2004). Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element.. The Biochemical journal, 381(Pt 2), 397-403. doi:10.1042/bj20031793
Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin.
Burdyga, G., Lal, S., Varro, A., Dimaline, R., Thompson, D. G., & Dockray, G. J. (2004). Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(11), 2708-2715. doi:10.1523/jneurosci.5404-03.2004
Glycine-extended gastrin promotes the growth of lung cancer
Koh, T. J., Field, J. K., Varro, A., Liloglou, L., Fielding, P., Cui, G., . . . Wang, T. C. (2004). Glycine-extended gastrin promotes the growth of lung cancer. Cancer Research, 64(1), 196-201. doi:10.1158/0008-5472.CAN-03-2112
Glycine-extended gastrin promotes the growth of lung cancer
Koh, T. J., Field, J. K., Varro, A., Liloglou, T., Fielding, P., Cui, G. L., . . . Wang, T. C. (2004). Glycine-extended gastrin promotes the growth of lung cancer. CANCER RESEARCH, 64(1), 196-201. doi:10.1158/0008-5472.CAN-03-2112
Glycine-extended gastrin promotes the growth of lung cancer
Koh, T. J., Field, J. K., Varro, A., Liloglou, T., Fielding, P., Cui, G. L., . . . Wang, T. C. (2004). Glycine-extended gastrin promotes the growth of lung cancer. Cancer Research, 64(1), 196-201. Retrieved from http://cancerres.aacrjournals.org/cgi/reprint/64/1/196
Helicobacter pylori induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-κB and RhoA: implications for invasion and apoptosis
Varro, A., Noble, P. J., Pritchard, D. M., Kennedy, S., Hart, C. A., Dimaline, R., & Dockray, G. J. (2004). Helicobacter pylori induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-κB and RhoA: implications for invasion and apoptosis. Cancer Res, 64(5), 1695-1702. Retrieved from http://cancerres.aacrjournals.org/cgi/reprint/64/5/1695
2003
Stimulation of MMP-7 (matrilysin) by <i>Helicobacter pylori</i> in human gastric epithelial cells:: role in epithelial cell migration
Wroblewski, L. E., Noble, P. J. M., Pagliocca, A., Pritchard, D. M., Hart, C. A., Campbell, F., . . . Varro, A. (2003). Stimulation of MMP-7 (matrilysin) by <i>Helicobacter pylori</i> in human gastric epithelial cells:: role in epithelial cell migration. JOURNAL OF CELL SCIENCE, 116(14), 3017-3026. doi:10.1242/jcs.00518
Stimulation of MMP-7 (matrilysin) by Helicobacter pylori in human gastric epithelial cells: role in epithelial cell migration
Wroblewski, L. E., Noble, P. J., Pagliocca, A., Pritchard, D. M., Hart, C. A., Campbell, F., . . . Varro, A. (2003). Stimulation of MMP-7 (matrilysin) by Helicobacter pylori in human gastric epithelial cells: role in epithelial cell migration. J Cell Sci, 116(Pt 14), 3017-3026. doi:10.1242/10.1242/jcs.00518
Stimulation of gastrin-CCK<sub>B</sub> receptor promotes migration of gastric AGS cells via multiple paracrine pathways
Noble, P. J. M., Wilde, G., White, M. R. H., Pennington, S. R., Dockray, G. J., & Varro, A. (2003). Stimulation of gastrin-CCK<sub>B</sub> receptor promotes migration of gastric AGS cells via multiple paracrine pathways. American Journal of Physiology-Gastrointestinal and Liver Physiology, 284(1), G75-G84. doi:10.1152/ajpgi.00300.2002
2002
Gastrin-stimulated gastric epithelial cell invasion: the role and mechanism of increased matrix metalloproteinase 9 expression
Wroblewski, L. E., Pritchard, D. M., Carter, S., & Varro, A. (2002). Gastrin-stimulated gastric epithelial cell invasion: the role and mechanism of increased matrix metalloproteinase 9 expression. BIOCHEMICAL JOURNAL, 365, 873-879. doi:10.1042/BJ20020068
Stimulation of the gastrin-cholecystokinin<sub>B</sub>receptor promotes branching morphogenesis in gastric AGS cells
Pagliocca, A., Wroblewski, L. E., Ashcroft, F. J., Noble, P. J., Dockray, G. J., & Varro, A. (2002). Stimulation of the gastrin-cholecystokinin<sub>B</sub>receptor promotes branching morphogenesis in gastric AGS cells. American Journal of Physiology-Gastrointestinal and Liver Physiology, 283(2), G292-G299. doi:10.1152/ajpgi.00056.2002
Identification of plasminogen activator inhibitor-2 as a gastrin-regulated gene: Role of Rho GTPase and menin.
Varro, A., Hemers, E., Archer, D., Pagliocca, A., Haigh, C., Ahmed, S., . . . Dockray, G. J. (2002). Identification of plasminogen activator inhibitor-2 as a gastrin-regulated gene: Role of Rho GTPase and menin.. Gastroenterology, 123(1), 271-280. doi:10.1053/gast.2002.34162
Gastrin-cholecystokinin(B) receptor expression in AGS cells is associated with direct inhibition and indirect stimulation of cell proliferation via paracrine activation of the epidermal growth factor receptor
Varro, A., Noble, P. J., Wroblewski, L. E., Bishop, L., & Dockray, G. J. (2002). Gastrin-cholecystokinin(B) receptor expression in AGS cells is associated with direct inhibition and indirect stimulation of cell proliferation via paracrine activation of the epidermal growth factor receptor. Gut, 50(6), 827-833.
Expression of the leptin receptor in rat and human nodose ganglion neurones.
Burdyga, G., Spiller, D., Morris, R., Lal, S., Thompson, D. G., Saeed, S., . . . Dockray, G. J. (2002). Expression of the leptin receptor in rat and human nodose ganglion neurones.. Neuroscience, 109(2), 339-347. doi:10.1016/s0306-4522(01)00474-2
Gastrin-cholecystokininB receptor expression in AGS cells is associated with direct inhibition and indirect stimulation of cell proliferation via paracrine activation of the EGF-receptor
Varro, A., Noble, P. -J., Wroblewski, L., Bishop, L., & Dockray, G. J. (2002). Gastrin-cholecystokininB receptor expression in AGS cells is associated with direct inhibition and indirect stimulation of cell proliferation via paracrine activation of the EGF-receptor. Gut, 50(6), 827-833.
2001
Measurement of secretory vesicle pH reveals intravesicular alkalinization by vesicular monoamine transporter type 2 resulting in inhibition of prohormone cleavage.
Blackmore, C. G., Varro, A., Dimaline, R., Bishop, L., Gallacher, D. V., & Dockray, G. J. (2001). Measurement of secretory vesicle pH reveals intravesicular alkalinization by vesicular monoamine transporter type 2 resulting in inhibition of prohormone cleavage.. The Journal of physiology, 531(Pt 3), 605-617. doi:10.1111/j.1469-7793.2001.0605h.x