Research
Drug Toxicity via Mitochondrial Dysfunction: pathways from fundamental mechanisms to clinical impact
Drug-induced mitochondrial toxicity is a major pathway in adverse drug-reactions across many organs. Within this mitochondrial dysfunction is cited as a major pathway in drug-induced liver injury (DILI). However, there is little evidence of how this pathway translates to the clinical onset of hepatotoxicity in certain individuals. Therefore the research of the Bioenergetic Group, led by Dr Chadwick, within the MRC Centre for Drug Safety Science is focused upon elucidating the fundamental mechanisms of drug-induced mitochondrial dysfunction, in appropriate in vitro models, and translating this knowledge to understand the molecular and genetic factors underlying individual susceptibility to mitotoxicants. Current research themes include:
1) Novel and advanced in vitro models to identify and investigate drug-induced mitochondrial dysfunction.
2) Mechanistic understanding of the role of mitochondrial dysfunction in cell death and adverse drug reactions.
3) Understanding the link between bioenergetic phenotype and individual susceptibility.
4) Investigating potential translational biomarkers of drug-induced mitochondrial dysfunction.
5) Evaluating the safety of novel mitochondria-targeted compounds.
Research grants
PhD Bench fees Faten Fahad I Bin Dayel (201424089)
ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)
October 2019 - September 2022
Mitochondrial toxicity research
JANSSEN PHARMACEUTICALS (BELGIUM)
February 2017 - June 2020
Bench Fees for Ehdaa Yousef I Ali (201623070)
ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)
January 2023 - January 2025
Provision of a MassArray Mass-spectrometry based multiplex genotyping platform (Agena Biosciences).
MEDICAL RESEARCH COUNCIL
July 2023 - June 2025
Bench fees - Tahani Talea N ALRehaili - 201670941
ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)
November 2023 - October 2027
Automated high-resolution microscope platform with robotics to study pharmacodynamics in 3D cell cultures
MEDICAL RESEARCH COUNCIL
November 2022 - March 2023
Bench Fees for Mohammed N. Bosakhar (201284267)
THE CULTURAL OFFICE OF THE EMBASSY OF THE STATE OF KUWAIT (UK)
January 2022 - January 2025
Utilising point-of-care technology in cardiovascular surgery for the identification of pathologic haemolysis implicated in Acute Kidney Injury (AKI).
KIDNEY RESEARCH UK (UK)
October 2022 - September 2024
CASE Top-Up - Miss A Ball
GLAXOSMITHKLINE (UK)
October 2014 - September 2018
Structure Activity Relationships in Redox Cycling
GLAXOSMITHKLINE RESEARCH & DEVELOPMENT LIMITED (UK)
October 2013 - September 2017