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2024

Expression of versican isoforms V0/V1 by pancreatic cancer associated fibroblasts increases fibroblast proliferation.

Elhashani, S., Glenn, M., Raymant, M., Schmid, M. C., & Mielgo, A. (2024). Expression of versican isoforms V0/V1 by pancreatic cancer associated fibroblasts increases fibroblast proliferation.. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 24(5), 719-731. doi:10.1016/j.pan.2024.04.008

DOI
10.1016/j.pan.2024.04.008
Journal article

Robust and consistent biomarker candidates identification by a machine learning approach applied to pancreatic ductal adenocarcinoma metastasis.

Mahawan, T., Luckett, T., Mielgo Iza, A., Pornputtapong, N., & Caamaño Gutiérrez, E. (2024). Robust and consistent biomarker candidates identification by a machine learning approach applied to pancreatic ductal adenocarcinoma metastasis.. BMC medical informatics and decision making, 24(Suppl 4), 175. doi:10.1186/s12911-024-02578-0

DOI
10.1186/s12911-024-02578-0
Journal article

Inhibition of insulin-like growth factors increases production of CXCL9/10 by macrophages and fibroblasts and facilitates CD8+ cytotoxic T cell recruitment to pancreatic tumours

Freeman, P., Bellomo, G., Ireland, L., Abudula, M., Luckett, T., Oberst, M., . . . Mielgo, A. (n.d.). Inhibition of insulin-like growth factors increases production of CXCL9/10 by macrophages and fibroblasts and facilitates CD8+ cytotoxic T cell recruitment to pancreatic tumours. Frontiers in Immunology, 15. doi:10.3389/fimmu.2024.1382538

DOI
10.3389/fimmu.2024.1382538
Journal article

2023

PINCER (A Platform Study for solId orgaN CancERs): an agile pan-network platform study to deliver high-quality translational research

Jones, R. P., Mielgo, A., Schmid, M., Bury, D., Andrews, T., Burdak-Rothkamm, S., . . . Vimalachandran, D. (2023). PINCER (A Platform Study for solId orgaN CancERs): an agile pan-network platform study to deliver high-quality translational research. BRITISH JOURNAL OF SURGERY. doi:10.1093/bjs/znad097

DOI
10.1093/bjs/znad097
Journal article

2022

2020

2019

2018

2017

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2015

2014

An integrin β3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.

Seguin, L., Kato, S., Franovic, A., Camargo, M. F., Lesperance, J., Elliott, K. C., . . . Cheresh, D. A. (2014). An integrin β3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.. Nature Cell Biology, 16(5), 457-468. doi:10.1038/ncb2953

DOI
10.1038/ncb2953
Journal article

2013

Impact of tumour associated macrophages in pancreatic cancer

Mielgo, A., & Schmid, M. C. (2013). Impact of tumour associated macrophages in pancreatic cancer. BMB REPORTS, 46(3), 131-138. doi:10.5483/BMBRep.2013.46.3.036

DOI
10.5483/BMBRep.2013.46.3.036
Journal article

2012

Caspase-8 isoform 6 promotes death effector filament formation independent of microtubules.

Yuan, R. T., Young, S., Liang, J., Schmid, M. C., Mielgo, A., & Stupack, D. G. (2012). Caspase-8 isoform 6 promotes death effector filament formation independent of microtubules.. Apoptosis..

Journal article

2011

A MEK-independent role for CRAF in mitosis and tumor progression

Mielgo, A., Seguin, L., Huang, M., Camargo, M. F., Anand, S., Franovic, A., . . . Cheresh, D. A. (2011). A MEK-independent role for CRAF in mitosis and tumor progression. NATURE MEDICINE, 17(12), 1641-U156. doi:10.1038/nm.2464

DOI
10.1038/nm.2464
Journal article

Activated Src kinase accelerates KrasG12D-dependent pancreatic neoplasia and promotes oncogenic addiction.

Shields, D. J., Murphy, E., Desgrosellier, J. S., Mielgo, A., Barnes, L., Lesperance, J., . . . Cheresh., D. A. (2011). Activated Src kinase accelerates KrasG12D-dependent pancreatic neoplasia and promotes oncogenic addiction.. Oncogene.

Journal article

2010

PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments

Tanjoni, I., Walsh, C., Uryu, S., Mielgo, A., Tomar, A., Nam, J. -O., . . . Schlaepfer, D. (2010). PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol. Ther.

Journal article

Proc. Natl. Acad. Sci.

Shields, D. J., Niessen, S., Murphy, E., Mielgo, A., Barnes, L., Lesperance, J., . . . Cheresh., D. A. (2010). Proc. Natl. Acad. Sci..

Journal article

Rab5 mediates caspase 8 promoted cell motility and metastasis.

Torres, V., Mielgo, A., Barbero, S., Hsiao, R., Wilkins, J. A., Schmid, S. L., & Stupack, D. G. (2010). Rab5 mediates caspase 8 promoted cell motility and metastasis.. Mol. Biol. Cell.

Journal article

2009

The Death Effector Domains of Caspase-8 Induce Terminal Differentiation

Mielgo, A., Torres, V. A., Schmid, M. C., Graf, R., Zeitlin, S. G., Lee, P., . . . Stupack, D. G. (2009). The Death Effector Domains of Caspase-8 Induce Terminal Differentiation. PLOS ONE, 4(11). doi:10.1371/journal.pone.0007879

DOI
10.1371/journal.pone.0007879
Journal article

Caspase 8 association with the focal adhesion complex promotes cellular migration and cancer metastasis

Barbero, S., Mielgo, A., Wu, L., Shields, D., Teitz, T., Mikolon, D., . . . Stupack, D. (2009). Caspase 8 association with the focal adhesion complex promotes cellular migration and cancer metastasis. Cancer Research.

Journal article

Paclitaxel promotes a caspase 8-mediated apoptosis via death effector domain association with microtubules.

Mielgo, A., Torres, V. A., Clair, K., & Stupack, D. G. (2009). Paclitaxel promotes a caspase 8-mediated apoptosis via death effector domain association with microtubules.. Oncogene.

Journal article

2008

Apoptosis and pathogenesis of melanoma and non-melanoma skin cancer.

Erb, P., Ji, J., Kump, E., Mielgo, A., & Wernli, M. (2008). Apoptosis and pathogenesis of melanoma and non-melanoma skin cancer.. Adv. Exp. Med. Biol..

Journal article

Caspase 8 promotes peripheral localization and activation of Rab5. .

Torres, V. A., Mielgo, A., Anderson, D., & Stupack, D. G. (2008). Caspase 8 promotes peripheral localization and activation of Rab5. .. J. Biol. Chem.

Journal article

Distinct FAK-Src activation events promote alpha5beta1 and alpha4beta1 integrin-stimulated neuroblastoma cell motility.

Wu, L., Bernard-Trifilo, J. A., lim, Y., Lim, S. -T., Mitra, S. K., Uryu, S., . . . Schlaepfer, D. D. (2008). Distinct FAK-Src activation events promote alpha5beta1 and alpha4beta1 integrin-stimulated neuroblastoma cell motility.. Oncogene.

Journal article

Identification of a critical tyrosine residue in caspase 8 that promotes cell migration.

Barbero, S., Barila, D., Mielgo, A., Stagni, V., Clair, K., & Stupack., D. (2008). Identification of a critical tyrosine residue in caspase 8 that promotes cell migration.. J. Biol. Chem.

Journal article

The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8.

Mielgo, A., Wrasidlo, W., Torres, V. A., Barbero, S., Stoletov, K., Suyama, T. L., . . . Stupack, D. G. (2008). The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8.. Proc. Natl. Acad. Sci..

Journal article

2007

The CD44 standard/ezrin complex regulates Fas-mediated apoptosis in Jurkat cells

Mielgo, A., Brondani, V., Landmann, L., Glaser-Ruhm, A., Erb, P., Stupack, D., & Guenthert, U. (2007). The CD44 standard/ezrin complex regulates Fas-mediated apoptosis in Jurkat cells. APOPTOSIS, 12(11), 2051-2061. doi:10.1007/s10495-007-0115-3

DOI
10.1007/s10495-007-0115-3
Journal article

2006

A novel antiapoptotic mechanism based on interference of Fas signaling by CD44 variant isoforms

Mielgo, A., van Driel, M., Bloem, A., Landmann, L., & Günthert, U. (2006). A novel antiapoptotic mechanism based on interference of Fas signaling by CD44 variant isoforms. CELL DEATH AND DIFFERENTIATION, 13(3), 465-477. doi:10.1038/sj.cdd.4401763

DOI
10.1038/sj.cdd.4401763
Journal article

2005

Fas-ligand gene silencing in basal cell carcinoma tissue with small interfering RNA.

Ji, J., Wernly, M., Mielgo, A., Buechner, S. A., & Erb., P. (2005). Fas-ligand gene silencing in basal cell carcinoma tissue with small interfering RNA.. Gene Therapy.

Journal article