Publications
Selected publications
- Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species (Journal article - 2012)
- A comprehensive evaluation of rodent malaria parasite genomes and gene expression (Journal article - 2014)
- An invariant <i>Trypanosoma vivax</i> vaccine antigen induces protective immunity (Journal article - 2021)
- Variant antigen diversity in Trypanosoma vivax is not driven by recombination. (Journal article - 2020)
- Variant antigen repertoires in Trypanosoma congolense populations and experimental infections can be profiled from deep sequence data using universal protein motifs (Journal article - 2018)
- Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism (Journal article - 2016)
- Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax (Journal article - 2015)
- The genome of the simian and human malaria parasite <i>Plasmodium knowlesi</i> (Journal article - 2008)
2024
Diversification of sphingolipid synthase activities in kinetoplastid protozoa.
Ciganda, M., Jackson, A. P., & Bangs, J. D. (2024). Diversification of sphingolipid synthase activities in kinetoplastid protozoa.. Molecular and biochemical parasitology, 260, 111656. doi:10.1016/j.molbiopara.2024.111656
The 2024 British Society for Parasitology Spring Meeting: promoting innovation across the community.
Jackson, A. P., Ahmed, F., Bent, L., Deles, G., Lester, E., & Ogunmola, J. (2024). The 2024 British Society for Parasitology Spring Meeting: promoting innovation across the community.. Trends in parasitology, 40(7), 531-536. doi:10.1016/j.pt.2024.05.009
2023
Evolutionary analysis of cellular reduction and anaerobicity in the hyper-prevalent gut microbe Blastocystis
Zahonova, K., Low, R. S., Warren, C. J., Cantoni, D., Herman, E. K., Yiangou, L., . . . Tsaousis, A. D. (2023). Evolutionary analysis of cellular reduction and anaerobicity in the hyper-prevalent gut microbe Blastocystis. CURRENT BIOLOGY, 33(12), 2449-+. doi:10.1016/j.cub.2023.05.025
A parasite DNA binding protein with potential to influence disease susceptibility acts as an analogue of mammalian HMGA transcription factors
Durrani, Z., Kinnaird, J., Cheng, C. W., Bruhlmann, F., Capewell, P., Jackson, A., . . . Shiels, B. (2023). A parasite DNA binding protein with potential to influence disease susceptibility acts as an analogue of mammalian HMGA transcription factors. PLOS ONE, 18(6). doi:10.1371/journal.pone.0286526
2022
Molecular and epidemiological surveillance of <i>Plasmodium</i> spp. during a mortality event affecting Humboldt penguins (<i>Spheniscus humboldti</i>) at a zoo in the UK
Gonzalez-Olvera, M., Hernandez-Colina, A., Himmel, T., Eckley, L., Lopez, J., Chantrey, J., . . . Jackson, A. P. (2022). Molecular and epidemiological surveillance of <i>Plasmodium</i> spp. during a mortality event affecting Humboldt penguins (<i>Spheniscus humboldti</i>) at a zoo in the UK. INTERNATIONAL JOURNAL FOR PARASITOLOGY-PARASITES AND WILDLIFE, 19, 26-37. doi:10.1016/j.ijppaw.2022.06.010
Transcriptomic profiling of Trypanosoma congolense mouthpart parasites from naturally infected flies.
Silva Pereira, S., Mathenge, K., Masiga, D., & Jackson, A. (2022). Transcriptomic profiling of Trypanosoma congolense mouthpart parasites from naturally infected flies.. Parasites & vectors, 15(1), 152. doi:10.1186/s13071-022-05258-y
<i>Vivaxin</i>genes encode highly immunogenic non-variant antigens unique to the<i>Trypanosoma vivax</i>cell-surface
<i>Vivaxin</i> genes encode highly immunogenic, non-variant antigens on the <i>Trypanosoma vivax</i> cell-surface
Romero-Ramirez, A., Casas-Sanchez, A., Autheman, D., Duffy, C. W., Brandt, C., Clare, S., . . . Jackson, A. P. (2022). <i>Vivaxin</i> genes encode highly immunogenic, non-variant antigens on the <i>Trypanosoma vivax</i> cell-surface. PLOS NEGLECTED TROPICAL DISEASES, 16(9). doi:10.1371/journal.pntd.0010791
Evolution of the variant surface glycoprotein family in African trypanosomes
Pereira, S. S., Jackson, A. P., & Figueiredo, L. M. (2022). Evolution of the variant surface glycoprotein family in African trypanosomes. TRENDS IN PARASITOLOGY, 38(1), 23-36. doi:10.1016/j.pt.2021.07.012
2021
An invariant <i>Trypanosoma vivax</i> vaccine antigen induces protective immunity
Autheman, D., Crosnier, C., Clare, S., Goulding, D. A., Brandt, C., Harcourt, K., . . . Wright, G. J. (2021). An invariant <i>Trypanosoma vivax</i> vaccine antigen induces protective immunity. NATURE, 595(7865), 96-+. doi:10.1038/s41586-021-03597-x
<i>Bodo saltans</i> (Kinetoplastida) is dependent on a novel <i>Paracaedibacter</i>-like endosymbiont that possesses multiple putative toxin-antitoxin systems
Midha, S., Rigden, D. J., Siozios, S., Hurst, G. D. D., & Jackson, A. P. (2021). <i>Bodo saltans</i> (Kinetoplastida) is dependent on a novel <i>Paracaedibacter</i>-like endosymbiont that possesses multiple putative toxin-antitoxin systems. ISME JOURNAL, 15(6), 1680-1694. doi:10.1038/s41396-020-00879-6
Detection of Trypanosoma vivax in tissues of experimentally infected goats: what is the role of adipose tissue in the life cycle of this protozoon?
Machado, R. Z., de Almeida Castilho Neto, K. J. G., Goncalves, L. R., Machado, G. F., Rui Luvizotto, M. C., Vasconcelos, R. D. O., . . . Geraldes Teixeira, M. M. (2021). Detection of <i>Trypanosoma vivax</i> in tissues of experimentally infected goats: what is the role of adipose tissue in the life cycle of this protozoon?. REVISTA BRASILEIRA DE PARASITOLOGIA VETERINARIA, 30(4). doi:10.1590/S1984-29612021092
2020
Variant antigen diversity in Trypanosoma vivax is not driven by recombination.
Silva Pereira, S., de Almeida Castilho Neto, K. J. G., Duffy, C. W., Richards, P., Noyes, H., Ogugo, M., . . . Jackson, A. P. (2020). Variant antigen diversity in Trypanosoma vivax is not driven by recombination.. Nature communications, 11(1). doi:10.1038/s41467-020-14575-8
2019
VAPPER: High-throughput variant antigen profiling in African trypanosomes of livestock
Pereira, S. S., Heap, J., Jones, A. R., & Jackson, A. P. (2019). VAPPER: High-throughput variant antigen profiling in African trypanosomes of livestock. GIGASCIENCE, 8(9). doi:10.1093/gigascience/giz091
Clinical expression and antigenic profiles of a Plasmodium vivax vaccine candidate: merozoite surface protein 7 (PvMSP-7)
Cheng, C. W., Jongwutiwes,, S., Putaporntip, C., & Jackson, A. P. (2019). Clinical expression and antigenic profiles of a Plasmodium vivax vaccine candidate: Merozoite Surface Protein 7 (PvMSP-7). Malaria Journal, 18, 20 pages. doi:10.1186/s12936-019-2826-7
Transcriptome, proteome and draft genome of Euglena gracilis.
Ebenezer, T. E., Zoltner, M., Burrell, A., Nenarokova, A., Novák Vanclová, A. M. G., Prasad, B., . . . Field, M. C. (2019). Transcriptome, proteome and draft genome of Euglena gracilis.. BMC biology, 17(1), 11. doi:10.1186/s12915-019-0626-8
2018
The Structure of a Conserved Telomeric Region Associated with Variant Antigen Loci in the Blood Parasite Trypanosoma congolense
Abbas, A. H., Pereira, S. S., D'Archivio, S., Wickstead, B., Morrison, L. J., Hall, N., . . . Jackson, A. P. (2018). The Structure of a Conserved Telomeric Region Associated with Variant Antigen Loci in the Blood Parasite Trypanosoma congolense. Genome Biology and Evolution, 10(9), 2458-2473. doi:10.1093/gbe/evy186
Variant antigen repertoires in Trypanosoma congolense populations and experimental infections can be profiled from deep sequence data using universal protein motifs
Pereira, S. S., Casas-Sanchez, A., Haines, L. R., Absolomon, K., Ogugo, M., Sanders, M., . . . Jackson, A. P. (n.d.). Variant antigen repertoires in Trypanosoma congolense populations and experimental infections can be profiled from deep sequence data using universal protein motifs. GENOME RESEARCH, 28(9), 1383-1394. doi:10.1101/gr.234146.118
UDP-glycosyltransferase genes in trypanosomatid genomes have diversified independently to meet the distinct developmental needs of parasite adaptations
Pereira, S. S., & Jackson, A. P. (2018). UDP-glycosyltransferase genes in trypanosomatid genomes have diversified independently to meet the distinct developmental needs of parasite adaptations. BMC EVOLUTIONARY BIOLOGY, 18. doi:10.1186/s12862-018-1149-6
2017
Emerging challenges in understanding trypanosome antigenic variation
McCulloch, R., Cobbold, C. A., Figueiredo, L., Jackson, A., Morrison, L. J., Mugnier, M. R., . . . Matthews, K. (2017). Emerging challenges in understanding trypanosome antigenic variation.. Emerging topics in life sciences, 1(6), 585-592. doi:10.1042/etls20170104
2016
Variant Exported Blood-Stage Proteins Encoded by Plasmodium Multigene Families Are Expressed in Liver Stages Where They Are Exported into the Parasitophorous Vacuole.
Fougere, A., Jackson, A. P., Bechtsi, D. P., Braks, J. A. M., Annoura, T., Fonager, J., . . . Franke-Fayard, B. (2016). Variant Exported Blood-Stage Proteins Encoded by <i>Plasmodium</i> Multigene Families Are Expressed in Liver Stages Where They Are Exported into the Parasitophorous Vacuole. PLOS PATHOGENS, 12(11). doi:10.1371/journal.ppat.1005917
Gene family phylogeny and the evolution of parasite cell surfaces
Jackson, A. P. (2016). Gene family phylogeny and the evolution of parasite cell surfaces. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 209(1-2), 64-75. doi:10.1016/j.molbiopara.2016.03.007
Genome of <i>Leptomonas pyrrhocoris</i>: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of <i>Leishmania</i>
Flegontov, P., Butenko, A., Firsov, S., Kraeva, N., Elias, M., Field, M. C., . . . Lukes, J. (2016). Genome of <i>Leptomonas pyrrhocoris</i>: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of <i>Leishmania</i>. SCIENTIFIC REPORTS, 6. doi:10.1038/srep23704
Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism
Jackson, A. P., Otto, T. D., Aslett, M., Armstrong, S. D., Bringaud, F., Schlacht, A., . . . Berriman, M. (2016). Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism. Current Biology, 26(2), 161-172. doi:10.1016/j.cub.2015.11.055
2015
Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax
Jackson, A., Goyard, S., Xia, D., Foth, B. J., Sanders, M., Wastling, J., . . . Berriman, M. (2015). Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax. PLoS Neglected Tropical Diseases, 9(8). doi:10.1371/journal.pntd.0003975
Genome evolution in trypanosomatid parasites
Jackson, A. P. (2015). Genome evolution in trypanosomatid parasites. PARASITOLOGY, 142, S40-S56. doi:10.1017/S0031182014000894
Preface: the evolution of parasite genomes and the origins of parasitism
Jackson, A. P. (2015). Preface: the evolution of parasite genomes and the origins of parasitism. PARASITOLOGY, 142, S1-S5. doi:10.1017/S0031182014001516
Genome and Phylogenetic Analyses of <i>Trypanosoma evansi</i> Reveal Extensive Similarity to <i>T</i>. <i>brucei</i> and Multiple Independent Origins for Dyskinetoplasty
Carnes, J., Anupama, A., Balmer, O., Jackson, A., Lewis, M., Brown, R., . . . Schnaufer, A. (2015). Genome and Phylogenetic Analyses of <i>Trypanosoma evansi</i> Reveal Extensive Similarity to <i>T</i>. <i>brucei</i> and Multiple Independent Origins for Dyskinetoplasty. PLOS NEGLECTED TROPICAL DISEASES, 9(1). doi:10.1371/journal.pntd.0003404
2014
A comprehensive evaluation of rodent malaria parasite genomes and gene expression
Otto, T. D., Boehme, U., Jackson, A. P., Hunt, M., Franke-Fayard, B., Hoeijmakers, W. A. M., . . . Janse, C. J. (2014). A comprehensive evaluation of rodent malaria parasite genomes and gene expression. BMC BIOLOGY, 12. doi:10.1186/s12915-014-0086-0
The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction
Jackson, A. P., Otto, T. D., Darby, A., Ramaprasad, A., Xia, D., Echaide, I. E., . . . Pain, A. (2014). The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction. Nucleic Acids Research, 42(11), 7113-7131. doi:10.1093/nar/gku322
The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.
Jackson, A. P., Otto, T. D., Darby, A., Ramaprasad, A., Xia, D., Echaide, I. E., . . . Pain, A. (2014). The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.. Nucleic Acids Research, 42(11), 7113-7131.
2013
A Cell-surface Phylome for African Trypanosomes
Jackson, A. P., Allison, H. C., Barry, J. D., Field, M. C., Hertz-Fowler, C., & Berriman, M. (2013). A Cell-surface Phylome for African Trypanosomes. PLOS NEGLECTED TROPICAL DISEASES, 7(3). doi:10.1371/journal.pntd.0002121
2012
The Evolution of Antigenic Variation in African Trypanosomes
Jackson, A. P., & Barry, J. D. (2012). The Evolution of Antigenic Variation in African Trypanosomes. In Unknown Book (pp. 324-336). Wiley. doi:10.1002/9781118308165.ch17
Characterization and gene expression analysis of the cir multi-gene family of Plasmodium chabaudi chabaudi (AS).
Lawton, J., Brugat, T., Yan, Y. X., Reid, A. J., Böhme, U., Otto, T. D., . . . Langhorne, J. (2012). Characterization and gene expression analysis of the cir multi-gene family of Plasmodium chabaudi chabaudi (AS).. BMC genomics, 13, 125. doi:10.1186/1471-2164-13-125
Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species
Jackson, A. P., Berry, A., Aslett, M., Allison, H. C., Burton, P., Vavrova-Anderson, J., . . . Berriman, M. (2012). Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(9), 3416-3421. doi:10.1073/pnas.1117313109
GeneDB-an annotation database for pathogens
Logan-Klumpler, F. J., De Silva, N., Boehme, U., Rogers, M. B., Velarde, G., McQuillan, J. A., . . . Berriman, M. (2012). GeneDB-an annotation database for pathogens. NUCLEIC ACIDS RESEARCH, 40(D1), D98-D108. doi:10.1093/nar/gkr1032
2010
<i>Leishmania</i>-Specific Surface Antigens Show Sub-Genus Sequence Variation and Immune Recognition
Depledge, D. P., MacLean, L. M., Hodgkinson, M. R., Smith, B. A., Jackson, A. P., Ma, S., . . . Smith, D. F. (2010). <i>Leishmania</i>-Specific Surface Antigens Show Sub-Genus Sequence Variation and Immune Recognition. PLOS NEGLECTED TROPICAL DISEASES, 4(9). doi:10.1371/journal.pntd.0000829
The Genome Sequence of <i>Trypanosoma brucei gambiense</i>, Causative Agent of Chronic Human African Trypanosomiasis
Jackson, A. P., Sanders, M., Berry, A., McQuillan, J., Aslett, M. A., Quail, M. A., . . . Hertz-Fowler, C. (2010). The Genome Sequence of <i>Trypanosoma brucei gambiense</i>, Causative Agent of Chronic Human African Trypanosomiasis. PLOS NEGLECTED TROPICAL DISEASES, 4(4). doi:10.1371/journal.pntd.0000658
The Evolution of Amastin Surface Glycoproteins in Trypanosomatid Parasites
Jackson, A. P. (2010). The Evolution of Amastin Surface Glycoproteins in Trypanosomatid Parasites. MOLECULAR BIOLOGY AND EVOLUTION, 27(1), 33-45. doi:10.1093/molbev/msp214
The genome sequence of Trypanosoma brucei gambiense: the causative agent of chronic sleeping sickness
Jackson, A. P., Sanders, M., Berry, A., McQuillan, J., Aslett, M. A., Quail, M. A., . . . Hertz-Fowler, C. (2010). The genome sequence of Trypanosoma brucei gambiense: the causative agent of chronic sleeping sickness. PLoS Neglected Tropical Diseases, 4, e658. Retrieved from http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0000658
2009
Evolutionary diversification of an ancient gene family (<i>rhs</i>) through C-terminal displacement
Jackson, A. P., Thomas, G. H., Parkhill, J., & Thomson, N. R. (2009). Evolutionary diversification of an ancient gene family (<i>rhs</i>) through C-terminal displacement. BMC GENOMICS, 10. doi:10.1186/1471-2164-10-584
Comparative genomics of the fungal pathogens <i>Candida dubliniensis</i> and <i>Candida albicans</i>
Jackson, A. P., Gamble, J. A., Yeomans, T., Moran, G. P., Saunders, D., Harris, D., . . . Berriman, M. (2009). Comparative genomics of the fungal pathogens <i>Candida dubliniensis</i> and <i>Candida albicans</i>. GENOME RESEARCH, 19(12), 2231-2244. doi:10.1101/gr.097501.109
2008
Insights into the genome sequence of a free-living Kinetoplastid: <i>Bodo saltans</i> (Kinetoplastida: Euglenozoa)
Jackson, A. P., Quail, M. A., & Berriman, M. (2008). Insights into the genome sequence of a free-living Kinetoplastid: <i>Bodo saltans</i> (Kinetoplastida: Euglenozoa). BMC GENOMICS, 9. doi:10.1186/1471-2164-9-594
Telomeric Expression Sites Are Highly Conserved in <i>Trypanosoma brucei</i>
Hertz-Fowler, C., Figueiredo, L. M., Quail, M. A., Becker, M., Jackson, A., Bason, N., . . . Berriman, M. (2008). Telomeric Expression Sites Are Highly Conserved in <i>Trypanosoma brucei</i>. PLOS ONE, 3(10). doi:10.1371/journal.pone.0003527
The genome of the simian and human malaria parasite <i>Plasmodium knowlesi</i>
Pain, A., Bohme, U., Berry, A. E., Mungall, K., Finn, R. D., Jackson, A. P., . . . Berriman, M. (2008). The genome of the simian and human malaria parasite <i>Plasmodium knowlesi</i>. NATURE, 455(7214), 799-7U7. doi:10.1038/nature07306
Multi-locus phylogenetic analysis of neotropical figs does not support co-speciation with the pollinators: The importance of systematic scale in fig/wasp cophylogenetic studies
Jackson, A. P., Machado, C. A., Robbins, N., & Herre, E. A. (2008). Multi-locus phylogenetic analysis of neotropical figs does not support co-speciation with the pollinators: The importance of systematic scale in fig/wasp cophylogenetic studies. Symbiosis, 45(1-3), 57-72.
Order within a mosaic distribution of mitochondrial <i>c</i>-type cytochrome biogenesis systems?
Allen, J. W. A., Jackson, A. P., Rigden, D. J., Willis, A. C., Ferguson, S. J., & Ginger, M. L. (2008). Order within a mosaic distribution of mitochondrial <i>c</i>-type cytochrome biogenesis systems?. FEBS JOURNAL, 275(10), 2385-2402. doi:10.1111/j.1742-4658.2008.06380.x
2007
Evolutionary consequences of a large duplication event in <i>Trypanosoma brucei</i>:: Chromosomes 4 and 8 are partial duplicons
Jackson, A. P. (2007). Evolutionary consequences of a large duplication event in <i>Trypanosoma brucei</i>:: Chromosomes 4 and 8 are partial duplicons. BMC GENOMICS, 8. doi:10.1186/1471-2164-8-432
Tandem gene arrays in <i>Trypanosoma brucei</i>:: Comparative phylogenomic analysis of duplicate sequence variation
Jackson, A. P. (2007). Tandem gene arrays in <i>Trypanosoma brucei</i>:: Comparative phylogenomic analysis of duplicate sequence variation. BMC EVOLUTIONARY BIOLOGY, 7. doi:10.1186/1471-2148-7-54
Origins of amino acid transporter loci in trypanosomatid parasites.
Jackson, A. P. (2007). Origins of amino acid transporter loci in trypanosomatid parasites.. BMC evolutionary biology, 7, 26. doi:10.1186/1471-2148-7-26
2006
Evolution of Tubulin Gene Arrays in Trypanosomatid parasites:: genomic restructuring in <i>Leishmania</i>
Jackson, A. P., Vaughan, S., & Gull, K. (2006). Evolution of Tubulin Gene Arrays in Trypanosomatid parasites:: genomic restructuring in <i>Leishmania</i>. BMC GENOMICS, 7. doi:10.1186/1471-2164-7-261
Comparative genomics and concerted evolution of β-tubulin paralogs in <i>Leishmania</i> spp
Jackson, A. P., Vaughan, S., & Gull, K. (2006). Comparative genomics and concerted evolution of β-tubulin paralogs in <i>Leishmania</i> spp. BMC GENOMICS, 7. doi:10.1186/1471-2164-7-137
2005
The effect of paralogous lineages on the application of reconciliation analysis by cophylogeny mapping
Jackson, A. P. (2005). The effect of paralogous lineages on the application of reconciliation analysis by cophylogeny mapping. SYSTEMATIC BIOLOGY, 54(1), 127-145. doi:10.1080/10635150590905911