Department of Human Anatomy and Cell Biology
New Medical School
Ashton Street
Liverpool
L69 3GE
UK
Tel +44 (0)151 794 5505
Fax +44 (0)151 794 5478



The Human Bone Cell Research group, based in the Department of Human Anatomy and Cell Biology, is one of the largest research groups in the University of Liverpool. Research is focused on the application of contemporary cellular and molecular biology to investigate the remodelling of human skeletal and articular tissues. Specific emphasis is placed on the development and application of techniques to culture bone and cartilage cells of human origin. This is the largest research group in the region undertaking osteoarticular research and consists of fifteen research staff who work in close co-operation and collaboration with orthopaedic surgeons, rheumatologists and other clinical colleagues throughout the Merseyside region. Funding is from the research councils, medical charities and the pharmaceutical and diagnostic industries.


GROUP LEADER Jim Gallagher
Major research interests include culture of human osteoblasts and the regulation of human bone remodelling (See:- Gallagher J.A., Gundle R., Beresford J.N. (1996) Isolation and Culture of Osteoblastic Cells from Human Bone. In 'Human Cell Culture Protocols' Ed. G.E. Jones, Humana Press Inc. pp 233-262 and Gallagher, J.A., Dillon J.P. (1997) Human Bone Remodeling. In 'Encyclopaedia of Human Biology' 2nd Edition. Ed. R. Dulbecco, Academic Press.
SENIOR SCIENTISTS
WayneBowler (ARC Fellow) Purinoceptors in tissue remodelling (See Bowler, W.B., Birch, M. A., Gallagher, J.A., Bilbe G (1995) Identification and cloning of human P2U purinoceptor present in osteoclastoma, bone and osteoblasts. Journal of Bone and Mineral Research 10: 1137-1145).
Cathy Walsh Human bone cell culture ( See Walsh C. A., Carron J.A., Gallagher J.A., (1996) Isolation of osteoclasts from human giant cell tumour and long term marrow cultures. In 'Human Cell Culture Protocols' Ed. G.E. Jones, Humana Press Inc. pp 263-276).
John Carron Matrix proteins in cartilage and bone (See Carron J.A., Walsh C.A., Fraser W.D., Gallagher J.A. (1995) Thrombospondin promotes resorption by osteoclasts in vitro. Biochimica Biophysical Research Communications 213:1017-1025).
Simon Wagstaff
RESEARCH ASSISTANTSJane Dillon
David McCreavy
PhD STUDENTS Joanna Start
Melanie Cleaton-Roberts
Alison Gartland
Peter Wilson
Katherine Buckley
Sarah Golding
TECHNICIANS Brenda Wlodarski

Funded by

Action Research SPARKS
Arthritis Research Campaign Action Research SPARKS North West
Cancer Research Fund



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This page was last updated by Simon Wagstaff on 6th September 1999