BIOL322 - Genome Organisation and Evolution

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BIOL322 - Genome Organisation and Evolution

Module co-ordinator : Dr. L.A. Iwanejko

Location

Science Lecture Block LTD

Times

Thursday, Friday: 16.00

Week
Lecture Content

13-18
11 Dr. L. Iwanejko
Introduction to Genome Organisation and Analysis

Some of the reasons for wanting to study and understand genome organisation will presented. Simple genomes will then be used to illustrate and introduce some of the techniques and concepts that will be encountered in more detail later in the course e.g. types of repeated sequences.

Structure of Eukaryotic Genomes — Simple Genomes

The yeast genome has now been completely sequenced and has been made publicly available in various databases. Analysis of this sequence information is extensive and on going. However most of the up to date information can be readily accessed via the Internet. We will be discussing some of the findings and the possible molecular mechanisms that have shaped the yeast genome. Other genomes such as Trypanosomes, will be used to provide evidence that these mechanisms operate during normal development in some organisms.

Mobile DNA

Large proportions of eukaryotic genomes are comprised of repeated DNA sequences that are categorised as mobile DNA. Some of these sequences from yeast and Drosophila will be examined and discussed. Conditions that cause mobilisation will be investigated and possible consequences for the host will be examined.

Mobile DNA in Complex Genomes — Plants and Humans

The origin and potential importance of LINES and SINES will be discussed with particular reference to plant and human genomes.

Gene Evolution

Exon shuffling and the origin of introns will be discussed. Current hypothesis and arguments for and against will be covered.

Overview of Eukaryotic Genome Organisation

A general picture of eukaryotic genomes will presented. The importance of understanding genome organisation will be discussed with particular reference to modern techniques that involve genome manipulation e.g. gene therapy, plant genetic manipulation.

Past examination questions/answers will be discussed.

CONTENTS | NEXT PAGE

Location	Science Lecture Block LTD
Times	Thursday, Friday: 16.00

Week	Lecture	Content
13-18	11	Dr. L. Iwanejko Introduction to Genome Organisation and Analysis Some of the reasons for wanting to study and understand genome organisation will presented. Simple genomes will then be used to illustrate and introduce some of the techniques and concepts that will be encountered in more detail later in the course e.g. types of repeated sequences. Structure of Eukaryotic Genomes — Simple Genomes The yeast genome has now been completely sequenced and has been made publicly available in various databases. Analysis of this sequence information is extensive and on going. However most of the up to date information can be readily accessed via the Internet. We will be discussing some of the findings and the possible molecular mechanisms that have shaped the yeast genome. Other genomes such as Trypanosomes, will be used to provide evidence that these mechanisms operate during normal development in some organisms. Mobile DNA Large proportions of eukaryotic genomes are comprised of repeated DNA sequences that are categorised as mobile DNA. Some of these sequences from yeast and Drosophila will be examined and discussed. Conditions that cause mobilisation will be investigated and possible consequences for the host will be examined. Mobile DNA in Complex Genomes — Plants and Humans The origin and potential importance of LINES and SINES will be discussed with particular reference to plant and human genomes. Gene Evolution Exon shuffling and the origin of introns will be discussed. Current hypothesis and arguments for and against will be covered. Overview of Eukaryotic Genome Organisation A general picture of eukaryotic genomes will presented. The importance of understanding genome organisation will be discussed with particular reference to modern techniques that involve genome manipulation e.g. gene therapy, plant genetic manipulation. Past examination questions/answers will be discussed.