Publications
2023
Small RNA signatures of the anterior cruciate ligament from patients with knee joint osteoarthritis
Kharaz-Ashraf, Y., Zamboulis, D., Fang, Y., Welting, T., Peffers, M., & Comerford, E. (2023). Small RNA signatures of the anterior cruciate ligament from patients with knee joint osteoarthritis. Frontiers in Molecular Biosciences. doi:10.3389/fmolb.2023.1266088
Multi-Omic Temporal Landscape of Plasma and Synovial Fluid-Derived Extracellular Vesicles Using an Experimental Model of Equine Osteoarthritis.
Anderson, J. R., Johnson, E., Jenkins, R., Jacobsen, S., Green, D., Walters, M., . . . Peffers, M. J. (2023). Multi-Omic Temporal Landscape of Plasma and Synovial Fluid-Derived Extracellular Vesicles Using an Experimental Model of Equine Osteoarthritis.. International journal of molecular sciences, 24(19), 14888. doi:10.3390/ijms241914888
2022
Proteoglycans play a rote in the viscoelastic behaviour of the canine cranial cruciate ligament
Readioff, R., Geraghty, B., Kharaz, Y. A., Elsheikh, A., & Comerford, E. (2022). Proteoglycans play a rote in the viscoelastic behaviour of the canine cranial cruciate ligament. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 10. doi:10.3389/fbioe.2022.984224
Age-related changes in microRNAs expression in cruciate ligaments of wild-stock house mice
Kharaz, Y. A., Goljanek-Whysall, K., Nye, G., Hurst, J. L., McArdle, A., & Comerford, E. J. (2022). Age-related changes in microRNAs expression in cruciate ligaments of wild-stock house mice. PHYSIOLOGICAL REPORTS, 10(16). doi:10.14814/phy2.15426
Identifying Novel Osteoarthritis-Associated Genes in Human Cartilage Using a Systematic Meta-Analysis and a Multi-Source Integrated Network
Shorter, E., Avelar, R., Zachariou, M., Spyrou, G. M., Raina, P., Smagul, A., . . . Poulet, B. (n.d.). Identifying Novel Osteoarthritis-Associated Genes in Human Cartilage Using a Systematic Meta-Analysis and a Multi-Source Integrated Network. International Journal of Molecular Sciences, 23(8), 4395. doi:10.3390/ijms23084395
2021
The effect of exercise on the protein profile of rat knee joint intra- and extra-articular ligaments
Kharaz, Y. A., Birch, H., Chester, A., Alchorne, E., Simpson, D., Clegg, P., & Comerford, E. (2021). The effect of exercise on the protein profile of rat knee joint intra- and extra-articular ligaments. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, 31(11), 2033-2043. doi:10.1111/sms.14023
Equine synovial fluid small non-coding RNA signatures in early osteoarthritis
Castanheira, C., Balaskas, P., Falls, C., Ashraf-Kharaz, Y., Clegg, P., Burke, K., . . . Peffers, M. J. (2021). Equine synovial fluid small non-coding RNA signatures in early osteoarthritis. BMC VETERINARY RESEARCH, 17(1). doi:10.1186/s12917-020-02707-7
Multiomics analysis of the mdx/mTR mouse model of Duchenne muscular dystrophy
Van Pelt, D., Kharaz, Y., Sarver, D., Eckhardt, L., Dzierzawski, J. T., Disser, N. P., . . . Mendias, C. (n.d.). Multiomics analysis of the mdx/mTR mouse model of Duchenne muscular dystrophy. Connective Tissue Research. doi:10.1080/03008207.2020.1791103
2020
Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix
Zamboulis, D. E., Thorpe, C. T., Ashraf Kharaz, Y., Birch, H. L., Screen, H. R. C., & Clegg, P. D. (n.d.). Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix. eLife, 2020(9). doi:10.7554/elife.58075
Small Non-Coding RNAome of Ageing Chondrocytes
Balaskas, P., Green, J. A., Haqqi, T. M., Dyer, P., Kharaz, Y. A., Fang, Y., . . . Peffers, M. J. (2020). Small Non-Coding RNAome of Ageing Chondrocytes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(16). doi:10.3390/ijms21165675
Equine synovial fluid small non-coding RNA signatures in early osteoarthritis
Castanheira, C., Balaskas, P., Falls, C., Ashraf-Kharaz, Y., Clegg, P., Burke, K., . . . Peffers, M. (2020). Equine synovial fluid small non-coding RNA signatures in early osteoarthritis. doi:10.1101/2020.05.01.066027
SMALL NUCLEOLAR RNAS AS MEDIATORS OF OXIDATIVE STRESS IN CROSS SPECIES CARTILAGE AND OSTEOARTHRITIS
Pimlott, Z., Hontoir, F., Kharaz, Y. A., Anderson, J., Dyer, P., Collins, J., . . . Peffers, M. J. (2020). SMALL NUCLEOLAR RNAS AS MEDIATORS OF OXIDATIVE STRESS IN CROSS SPECIES CARTILAGE AND OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 28 (pp. S342). Retrieved from https://www.webofscience.com/
THE EFFECT OF EXERCISE ON THE PROTEIN PROFILE OF RAT KNEE JOINT INTRA- AND EXTRA-ARTICULAR LIGAMENTS
Kharaz, Y. A., Birch, H., Allchorne, E., Chesten, A., Clegg, P., & Comerford, E. (2018). THE EFFECT OF EXERCISE ON THE PROTEIN PROFILE OF RAT KNEE JOINT INTRA- AND EXTRA-ARTICULAR LIGAMENTS. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S171). doi:10.1016/j.joca.2018.02.371
2019
Multiomics Analysis of the mdx/mTR Mouse Model of Duchenne Muscular Dystrophy
Comerford, E., & Mendias, C. (n.d.). Multiomics Analysis of the mdx/mTR Mouse Model of Duchenne Muscular Dystrophy. BioRxiv. doi:10.1101/589424
2018
Variations in internal structure, composition and protein distribution between intra- and extra-articular knee ligaments and tendons
Kharaz, Y. A., Canty-Laird, E. G., Tew, S. R., & Comerford, E. J. (2018). Variations in internal structure, composition and protein distribution between intra- and extra-articular knee ligaments and tendons. JOURNAL OF ANATOMY, 232(6), 943-955. doi:10.1111/joa.12802
AGE-RELATED CHANGES IN MICRORNAS EXPRESSION IN MOUSE CRUCIATE LIGAMENTS
Kharaz, Y. A., Whysall, K., Hurst, J., & Comerford, E. (2018). AGE-RELATED CHANGES IN MICRORNAS EXPRESSION IN MOUSE CRUCIATE LIGAMENTS. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S116-S117). doi:10.1016/j.joca.2018.02.254
The effect of exercise on the protein profile of rat knee joint intra- and extra-articular ligaments
Kharaz, Y. A., Birch, H., Allchorne, E., Chester, A., Clegg, P., & Comerford, E. (2018). The effect of exercise on the protein profile of rat knee joint intra- and extra-articular ligaments. In Osteoarthritis and Cartilage Vol. 26 (pp. S171). Elsevier BV. doi:10.1016/j.joca.2018.02.371
Donor age affects proteome composition of tenocyte-derived engineered tendon
Turlo, A. J., Kharaz, Y. A., Clegg, P. D., Anderson, J., & Peffers, M. J. (2018). Donor age affects proteome composition of tenocyte-derived engineered tendon. BMC BIOTECHNOLOGY, 18. doi:10.1186/s12896-018-0414-5
2017
Sex differences in tendon structure and function.
Sarver, D. C., Kharaz, Y. A., Sugg, K. B., Gumucio, J. P., Comerford, E., & Mendias, C. L. (2017). Sex differences in tendon structure and function.. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 35(10), 2117-2126. doi:10.1002/jor.23516
Nano-structure and mechanical changes in sclera following proteoglycan depletion
Zhuola, L., Kharaz, Y., Comerford, E., & Akhtar, R. (2017). Nano-structure and mechanical changes in sclera following proteoglycan depletion. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 98 (pp. A11). Retrieved from https://www.webofscience.com/
Comparison between chaotropic and detergent-based sample preparation workflow in tendon for mass spectrometry analysis
Ashraf Kharaz, Y., Zamboulis, D., Sander, K., Comerford, E., Clegg, P., & Peffers, M. (2017). Comparison between chaotropic and detergent-based sample preparation workflow in tendon for mass spectrometry analysis. Proteomics, 17(13-14). doi:10.1002/pmic.201700018
Biofunctionalisation of Electrospun Constructs with Fibrillin-1 for Anterior Cruciate Ligament Repair and Regeneration
Smith, Z., Kumar, D., Ramos Marques, D., Hu, M., Cain, S., Critchon, G., . . . Gough, J. (2017, June 26). Biofunctionalisation of Electrospun Constructs with Fibrillin-1 for Anterior Cruciate Ligament Repair and Regeneration. In eCells & Materials (pp. P584). Switzerland.
THE EFFECT OF DONOR AGE ON ENGINEERED TENDON TISSUE DERIVED FROM TENOCYTES AND MESENCHYMAL STEM CELLS
Turlo, A. J., Kharaz, Y. A., Clegg, P. D., Anderson, J., & Peffers, M. J. (2017). THE EFFECT OF DONOR AGE ON ENGINEERED TENDON TISSUE DERIVED FROM TENOCYTES AND MESENCHYMAL STEM CELLS. In OSTEOARTHRITIS AND CARTILAGE Vol. 25 (pp. S88). doi:10.1016/j.joca.2017.02.137
Age-related changes in ligament and cartilage composition are altered with exercise
Ashraf Kharaz, Y., Nye, G., Mcardle, A., Hurst, J., & Comerford, E. (2017). Age-related changes in ligament and cartilage composition are altered with exercise. In Orthopaedic Research Society. San Diego.
2016
Comparison of protein extraction methods in tendon for mass spectrometry analysis
Ashraf Kharaz, Y., Zamboulis, D., Sander, K., Comerford, E., Clegg, P., & Peffers, M. (2016). Comparison of protein extraction methods in tendon for mass spectrometry analysis. In International Journal of Experimental Pathology Vol. 9 (pp. A26). Chester University.
Proteomic differences between native and tissue-engineered tendon and ligament
Kharaz, Y. A., Tew, S. R., Peffers, M., Canty-Laird, E. G., & Comerford, E. (2016). Proteomic differences between native and tissue-engineered tendon and ligament. PROTEOMICS, 16(10), 1547-1556. doi:10.1002/pmic.201500459
Anterior cruciate ligamentocyte response to electrospun scaffolds decorated with fibrillin
Margues, D. R., Kumar, D., Crichton, G., Ashraf Kharaz, Y., Comerford, E., & Gough, J. E. (2016). Anterior cruciate ligamentocyte response to electrospun scaffolds decorated with fibrillin. In European Cells and Materials Vol. 32 (pp. 78). London: European Cells & Materials Ltd.
2015
Distribution and organisation comparison of extracellular matrix proteins between tendon and ligament
Ashraf Kharaz, Y., Tew, S. E., Canty-Laird, E. G., & Comerford, E. (2015). Distribution and organisation comparison of extracellular matrix proteins between tendon and ligament. In The Bone & Joint Journal Vol. 97-B.
The molecular and cellular differences between tendons and ligaments
Ashraf Kharaz, Y. (2015, March 15). The molecular and cellular differences between tendons and ligaments. (PhD Thesis, University of Liverpool).
2014
A COMPARISON OF THE EXTRACELLULAR MATRIX COMPOSITION OF TENDON/LIGAMENT TISSUE AND TISSUE ENGINEERED TENDON AND LIGAMENT CONSTRUCT
Kharaz, Y. A., Tew, S., Canty-Laird, E., & Comerford, E. (2014). A COMPARISON OF THE EXTRACELLULAR MATRIX COMPOSITION OF TENDON/LIGAMENT TISSUE AND TISSUE ENGINEERED TENDON AND LIGAMENT CONSTRUCT. In OSTEOARTHRITIS AND CARTILAGE Vol. 22 (pp. S313). doi:10.1016/j.joca.2014.02.580
Biochemical comparison of the extracellular matrix composition of tendon/ligament tissue and tissue engineered tendon/ligament constructs
Kharaz, A. K. A., Tew, S. R. T., Laird, E. G. L., & Comerford, E. C. (2014). Biochemical comparison of the extracellular matrix composition of tendon/ligament tissue and tissue engineered tendon/ligament constructs. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 95 (pp. A4-A5). Retrieved from https://www.webofscience.com/