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Xiaoli Meng

Dr Xiaoli Meng
Ph.D.

Contact

Xlmeng@liverpool.ac.uk

+44 (0)151 795 6066 Ext. 6066

Publications

Selected publications

  1. Activation of Human CD8+ T Cells with Nitroso Dapsone-Modified HLA-B*13:01-Binding Peptides. (Journal article - 2023)
  2. Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury (Journal article - 2023)
  3. Shared Clavulanate and Tazobactam Antigenic Determinants Activate T-Cells from Hypersensitive Patients (Journal article - 2022)
  4. Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives (Journal article - 2021)
  5. HLA DaB1*15:01-DQB1*06:02-Restricted Human CD4+T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts (Journal article - 2020)
  6. Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation (Journal article - 2020)
  7. CDDO-imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1. (Journal article - 2020)
  8. Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo (Journal article - 2019)
  9. Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017) (Journal article - 2018)
  10. Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients (Journal article - 2014)
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2024

Development and translation of a method of clinical utility for LC-MS/MS analysis to detect SARS-CoV-2 antigens from ONP swabs and saliva

DOI
10.26434/chemrxiv-2024-4t52c
Preprint

P15-06 Amoxicillin-induced liver injury: characterisation of amoxicillin-specific T-cells in healthy donors reveals unexpected HLA class I restrictions

Saville, E., Maier, C., Blackburn, J., Naisbitt, D., & Meng, X. (2024). P15-06 Amoxicillin-induced liver injury: characterisation of amoxicillin-specific T-cells in healthy donors reveals unexpected HLA class I restrictions. Toxicology Letters, 399, S230-S231. doi:10.1016/j.toxlet.2024.07.564

DOI
10.1016/j.toxlet.2024.07.564
Journal article

P15-14 Characterisation of liver-derived T-cells during and upon resolution of CFTR modulator induced liver injury

Clarke, E., Gardner, J., Gillgrass, L., Peckham, D., Meng, X., & Naisbitt, D. (2024). P15-14 Characterisation of liver-derived T-cells during and upon resolution of CFTR modulator induced liver injury. Toxicology Letters, 399, S234. doi:10.1016/j.toxlet.2024.07.572

DOI
10.1016/j.toxlet.2024.07.572
Journal article

Patients with <scp>naproxen‐induced</scp> liver injury display T‐cell memory responses toward an oxidative (S)‐<scp>O‐Desmethyl</scp> Naproxen metabolite but not the acyl glucuronide

Thomson, P., Fragkas, N., Kafu, L. M., Aithal, G. P., Lucena, M. I., Terracciano, L., . . . Naisbitt, D. J. (n.d.). Patients with <scp>naproxen‐induced</scp> liver injury display T‐cell memory responses toward an oxidative (S)‐<scp>O‐Desmethyl</scp> Naproxen metabolite but not the acyl glucuronide. Allergy. doi:10.1111/all.15830

DOI
10.1111/all.15830
Journal article

Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-Desmethyl Naproxen metabolite but not the acyl glucuronide

Thomson, P., Fragkas, N., Kafu, L. M., Aithal, G. P., Lucena, M. I., Terracciano, L., . . . Naisbitt, D. J. (2023). Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-Desmethyl Naproxen metabolite but not the acyl glucuronide. In ALLERGY. doi:10.1111/all.15830

DOI
10.1111/all.15830
Conference Paper

2023

Sodium valproate causes pancreatic injury in vitro and in vivo via dysregulation of one carbon metabolism

Cai, W., Chvanov, M., Awais, M., Meng, X., Latawiec, D., Brown, J., . . . Sutton, R. (2023). Sodium valproate causes pancreatic injury in vitro and in vivo via dysregulation of one carbon metabolism. Pancreatology, 23, e20-e21. doi:10.1016/j.pan.2023.06.453

DOI
10.1016/j.pan.2023.06.453
Journal article

2022

Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity

Hammond, S., Olsson-Brown, A., Grice, S., Gibson, A., Gardner, J., Castrejon-Flores, J. L., . . . Naisbitt, D. J. (2022). Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity. TOXICOLOGICAL SCIENCES, 186(1), 58-69. doi:10.1093/toxsci/kfab144

DOI
10.1093/toxsci/kfab144
Journal article

2021

Deciphering Adverse Drug Reactions: <i>In Vitro</i> Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01

Ogese, M. O., Lister, A., Gardner, J., Meng, X., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2021). Deciphering Adverse Drug Reactions: <i>In Vitro</i> Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01. TOXICOLOGICAL SCIENCES, 183(1), 139-153. doi:10.1093/toxsci/kfab084

DOI
10.1093/toxsci/kfab084
Journal article

In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs

Naisbitt, D. (2021). In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs. Frontiers in Immunology. doi:10.3389/fimmu.2021.630530

DOI
10.3389/fimmu.2021.630530
Journal article

Novel inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives

DOI
10.1101/2021.03.11.434764
Preprint

2020

Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury

Waddington, J. C., Ali, S. -E., Penman, S. L., Whitaker, P., Hamlett, J., Chadwick, A., . . . Meng, X. (2020). Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 33(12), 2939-2943. doi:10.1021/acs.chemrestox.0c00400

DOI
10.1021/acs.chemrestox.0c00400
Journal article

Safety perspectives on presently considered drugs for the treatment of COVID‐19

Penman, S. L., Kiy, R. T., Jensen, R. L., Beoku‐Betts, C., Alfirevic, A., Back, D., . . . Chadwick, A. E. (n.d.). Safety perspectives on presently considered drugs for the treatment of COVID‐19. British Journal of Pharmacology. doi:10.1111/bph.15204

DOI
10.1111/bph.15204
Journal article

2019

Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo

Tailor, A., Waddington, J. C., Hamlett, J., Maggs, J., Kafu, L., Farrell, J., . . . Meng, X. (2019). Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo. CHEMICAL RESEARCH IN TOXICOLOGY, 32(10), 2095-2106. doi:10.1021/acs.chemrestox.9b00282

DOI
10.1021/acs.chemrestox.9b00282
Journal article

Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01

Zhao, Q., Alhilali, K., Alzahrani, A., Almutairi, M., Amjad, J., Liu, H., . . . Naisbitt, D. J. (2019). Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01. Allergy, 74(8), 1533-1548. doi:10.1111/all.13769

DOI
10.1111/all.13769
Journal article

Beta-lactam protein binding leads to the presentation of novel MHC peptides, generating a potential immunogen for drug-hypersensitive reactions

Waddington, J., Meng, X., Illing, P., Tailor, A., Jenkins, R., Purcell, A., . . . Park, B. (2019). Beta-lactam protein binding leads to the presentation of novel MHC peptides, generating a potential immunogen for drug-hypersensitive reactions. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 176 (pp. 3004-3005). Retrieved from https://www.webofscience.com/

Conference Paper

2018

HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors

Usui, T., Tailor, A., Faulkner, L., Meng, X., Farrell, J., Daly, A. K., . . . Naisbitt, D. J. (2018). HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 31(10), 1022-1024. doi:10.1021/acs.chemrestox.8b00163

DOI
10.1021/acs.chemrestox.8b00163
Journal article

Mechanisms leading to T-cell activation in drug hypersensitivity

Meng, X., Yerly, D., & Naisbitt, D. J. (2018). Mechanisms leading to T-cell activation in drug hypersensitivity. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 18(4), 317-324. doi:10.1097/ACI.0000000000000458

DOI
10.1097/ACI.0000000000000458
Journal article

Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017)

Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2018). Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1952. doi:10.4049/jimmunol.1800020

DOI
10.4049/jimmunol.1800020
Journal article

2017

Dapsone and Nitroso Dapsone Activation of Naı̈ve T-Cells from Healthy Donors.

Alzahrani, A., Ogese, M., Meng, X., Waddington, J. C., Tailor, A., Farrell, J., . . . Naisbitt, D. (2017). Dapsone and Nitroso Dapsone Activation of Naive T-Cells from Healthy Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2174-2186. doi:10.1021/acs.chemrestox.7b00263

DOI
10.1021/acs.chemrestox.7b00263
Journal article

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients

Yip, V. L. M., Meng, X., Maggs, J. L., Jenkins, R., Marlot, P., Marson, A., . . . Pirmohamed, M. (2017). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients. Chemical Research in Toxicology, 30(7), 1419-1435. doi:10.1021/acs.chemrestox.7b00063

DOI
10.1021/acs.chemrestox.7b00063
Journal article

2016

No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with HLA-DRB1*07:01-Restricted Lapatinib-Induced Liver Injury

Faulkner, L., Meng, X., Naisbitt, D. J., Spraggs, C. F., & Park, B. K. (2016). No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with <i>HLA</i>-<i>DRB1</i>*07:01-Restricted Lapatinib-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 29(12), 2111-2113. doi:10.1021/acs.chemrestox.6b00400

DOI
10.1021/acs.chemrestox.6b00400
Journal article

A combination of clinical and genetic covariates significantly influence the metabolism of carbamazepine: potential implications for carbamazepine hypersensitivity

Yip, V. L. M., Meng, X., Maggs, J. L., Pertinez, H., Carr, D. F., Marson, A. G., . . . Pirmohamed, M. (2016). A combination of clinical and genetic covariates significantly influence the metabolism of carbamazepine: potential implications for carbamazepine hypersensitivity. London, UK.

Presentation material

7th drug hypersensitivity meeting: part one

Carr, D. F., Chung, W. -H., Jenkiins, R. E., Chaponda, M., Nwikue, G., Cornejo Castro, E. M., . . . Ruano, F. J. (2016). 7th drug hypersensitivity meeting: part one. Clinical and Translational Allergy, 6(S3). doi:10.1186/s13601-016-0121-z

DOI
10.1186/s13601-016-0121-z
Journal article

2015

Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin

Meng, X., Maggs, J. L., Usui, T., Whitaker, P., French, N. S., Naisbitt, D. J., & Park, B. K. (2015). Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin. Chemical Research in Toxicology, 28(1), 51-58. doi:10.1021/tx500285k

DOI
10.1021/tx500285k
Journal article

Characterization of Peroxidases Expressed in Human AntigenPresenting Cells and Analysis of the Covalent Binding of NitrosoSulfamethoxazole to Myeloperoxidase

Ogese, M. O., Jenkins,, R. E., Maggs, J. L., Meng, X., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2015). Characterization of Peroxidases Expressed in Human AntigenPresenting Cells and Analysis of the Covalent Binding of NitrosoSulfamethoxazole to Myeloperoxidase. Chemical Research in Toxicology, 28(1), 144-154. doi:10.1021/tx500458k

DOI
10.1021/tx500458k
Journal article

2014

Characterization of anti-drug antibodies and drug-responsive B-lymphocytes in piperacillin hypersensitive patients with cystic fibrosis

Amali, M., Sullivan, A., Farrell, J., Meng, X., Jenkins, R., Whitaker, P., . . . Naisbitt, D. J. (2014). Characterization of anti-drug antibodies and drug-responsive B-lymphocytes in piperacillin hypersensitive patients with cystic fibrosis. Clinical and translational allergy, 4(Suppl 3), P113. doi:10.1186/2045-7022-4-s3-p113

DOI
10.1186/2045-7022-4-s3-p113
Journal article

Isoniazid-specific T-cell Responses in patients with anti-tuberculosis drug related liver injury

Usui, T., Saide, K., Meng, X., Whitaker, P., Peckham, D., French, N., . . . Park, K. (2014). Isoniazid-specific T-cell Responses in patients with anti-tuberculosis drug related liver injury. Clinical and translational allergy, 4(Suppl 3), P116. doi:10.1186/2045-7022-4-s3-p116

DOI
10.1186/2045-7022-4-s3-p116
Journal article

Abacavir forms novel cross-linking abacavir protein adducts in patients

Meng, X., Lawrenson, A. S., Berry, N. G., Maggs, J. L., French, N. S., Back, D. J., . . . Park, B. K. (2014). Abacavir forms novel cross-linking abacavir protein adducts in patients. Chemical Research in Toxicology, 27(04), 524-535. doi:10.1021/tx400406p

DOI
10.1021/tx400406p
Journal article

Covalent adduction of carbamazepine 10, 11-epoxide with human serum albumin and glutathione S-transferase pi: implications for carbamazepine hypersensitivity

Yip, V., Maggs, J., Meng, X., Marson, A., Park, K., & Pirmohamed, M. (2014). Covalent adduction of carbamazepine 10, 11-epoxide with human serum albumin and glutathione S-transferase pi: implications for carbamazepine hypersensitivity. LANCET, 383, 114. Retrieved from https://www.webofscience.com/

Journal article

Dissecting the reaction of Phase II metabolites of ibuprofen and other NSAIDS with human plasma protein

Monrad, R. N., Errey, J. C., Barry, C. S., Iqbal, M., Meng, X., Iddon, L., . . . Davis, B. G. (2014). Dissecting the reaction of Phase II metabolites of ibuprofen and other NSAIDS with human plasma protein. CHEMICAL SCIENCE, 5(10), 3789-3794. doi:10.1039/c4sc01329h

DOI
10.1039/c4sc01329h
Journal article

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients

Hammond, T. G., Meng, X., Jenkins, R. E., Maggs, J. L., Castelazo, A. S., Regan, S. L., . . . Williams, D. P. (2014). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 350(2), 387-402. doi:10.1124/jpet.114.215079

DOI
10.1124/jpet.114.215079
Journal article

The importance of hapten - protein complex formation in the development of drug allergy

Faulkner, L., Meng, X., Park, B. K., & Naisbitt, D. J. (2014). The importance of hapten - protein complex formation in the development of drug allergy. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 14(4), 293-300. doi:10.1097/ACI.0000000000000078

DOI
10.1097/ACI.0000000000000078
Journal article

2013

β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis

Jenkins, R. E., Yaseen, F. S., Monshi, M. M., Whitaker, P., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2013). β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis. CHEMICAL RESEARCH IN TOXICOLOGY, 26(6), 963-975. doi:10.1021/tx400124m

DOI
10.1021/tx400124m
Journal article

Glucuronides from metabolites to medicines: a survey of the in vivo generation, chemical synthesis and properties of glucuronides.

Stachulski, A. V., & Meng, X. (2013). Glucuronides from metabolites to medicines: a survey of the in vivo generation, chemical synthesis and properties of glucuronides.. Natural product reports, 30(6), 806-848. doi:10.1039/c3np70003h

DOI
10.1039/c3np70003h
Journal article

Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients

Meng, X., Howarth, A., Earnshaw, C. J., Jenkins, R. E., French, N. S., Back, D. J., . . . Park, B. K. (2013). Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 26(4), 575-583. doi:10.1021/tx4000107

DOI
10.1021/tx4000107
Journal article

2012

Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis

El-Ghaiesh, S., Monshi, M. M., Whitaker, P., Jenkins, R., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 341(3), 597-610. doi:10.1124/jpet.111.190900

DOI
10.1124/jpet.111.190900
Journal article

2011

In vitro assessment of the interactions between diclofenac and tolmetin acyl glucuronide drug metabolites and human serum albumin

Hammond, T. G., Regan, S. L., Meng, X., Maggs, J. L., Jenkins, R. E., Kenna, J. G., . . . Park, B. K. (2011). In vitro assessment of the interactions between diclofenac and tolmetin acyl glucuronide drug metabolites and human serum albumin. Toxicology, 290(2-3), 142-143. doi:10.1016/j.tox.2011.09.072

DOI
10.1016/j.tox.2011.09.072
Journal article

Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients

Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. Journal of Pharmacology and Experimental Therapeutics, 338(3), 841-849. doi:10.1124/jpet.111.183871

DOI
10.1124/jpet.111.183871
Journal article

Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients

Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 338(3), 841-849. doi:10.1124/jpet.111.183871

DOI
10.1124/jpet.111.183871
Journal article

Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis

Whitaker, P., Meng, X., Lavergne, S. N., El-Ghaiesh, S., Monshi, M., Earnshaw, C., . . . Park, B. K. (2011). Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis. J Immunol, 187(1), 200-211.

Journal article

2010

Protein binding and pharmacokinetics of reactive acyl glucuronide drug metabolites

Hammond, T. G., Regan, S. L., Meng, X., Maggs, J. L., Jenkins, R. E., Kenna, G. L., . . . Park, B. K. (2010). Protein binding and pharmacokinetics of reactive acyl glucuronide drug metabolites. Toxicology, 278(3), 357-358. doi:10.1016/j.tox.2010.08.108

DOI
10.1016/j.tox.2010.08.108
Journal article

High-performance liquid chromatography/mass spectrometric and proton nuclear magnetic resonance spectroscopic studies of the transacylation and hydrolysis of the acyl glucuronides of a series of phenylacetic acids in buffer and human plasma.

Karlsson, E. S., Johnson, C. H., Sarda, S., Iddon, L., Iqbal, M., Meng, X., . . . Lindon, J. C. (2010). High-performance liquid chromatography/mass spectrometric and proton nuclear magnetic resonance spectroscopic studies of the transacylation and hydrolysis of the acyl glucuronides of a series of phenylacetic acids in buffer and human plasma.. Rapid communications in mass spectrometry : RCM, 24(20), 3043-3051. doi:10.1002/rcm.4740

DOI
10.1002/rcm.4740
Journal article

Integrated HPLC-MS and (1)H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides.

Johnson, C. H., Karlsson, E., Sarda, S., Iddon, L., Iqbal, M., Meng, X., . . . Lindon, J. C. (2010). Integrated HPLC-MS and (1)H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides.. Xenobiotica; the fate of foreign compounds in biological systems, 40(1), 9-23. doi:10.3109/00498250903348720

DOI
10.3109/00498250903348720
Journal article

2009

Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA <i>in vitro</i> and <i>in vivo</i>

Jenkins, R. E., Meng, X., Elliott, V. L., Kitteringham, N. R., Pirmohamed, M., & Park, B. K. (2009). Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA <i>in vitro</i> and <i>in vivo</i>. PROTEOMICS CLINICAL APPLICATIONS, 3(6), 720-729. doi:10.1002/prca.200800222

DOI
10.1002/prca.200800222
Journal article

Convenient syntheses of the in vivo carbohydrate metabolites of mycophenolic acid: reactivity of the acyl glucuronide

Jones, A. E., Wilson, H. K., Meath, P., Meng, X., Holt, D. W., Johnston, A., . . . Stachulski, A. V. (2009). Convenient syntheses of the in vivo carbohydrate metabolites of mycophenolic acid: reactivity of the acyl glucuronide. Tetrahedron Letters, 50(35), 4973-4977. doi:10.1016/j.tetlet.2009.06.060

DOI
10.1016/j.tetlet.2009.06.060
Journal article

Synthesis, transacylation kinetics and computational chemistry of a set of arylacetic acid 1β-<i>O</i>-acyl glucuronides

Berry, N. G., Iddon, L., Iqbal, M., Meng, X., Jayapal, P., Johnson, C. H., . . . Stachulski, A. V. (2009). Synthesis, transacylation kinetics and computational chemistry of a set of arylacetic acid 1β-<i>O</i>-acyl glucuronides. ORGANIC & BIOMOLECULAR CHEMISTRY, 7(12), 2525-2533. doi:10.1039/b822777b

DOI
10.1039/b822777b
Journal article

2008

Kinetic and J-resolved statistical total correlation NMR spectroscopy approaches to structural information recovery in complex reacting mixtures: application to acyl glucuronide intramolecular transacylation reactions.

Johnson, C. H., Athersuch, T. J., Wilson, I. D., Iddon, L., Meng, X., Stachulski, A. V., . . . Nicholson, J. K. (2008). Kinetic and J-resolved statistical total correlation NMR spectroscopy approaches to structural information recovery in complex reacting mixtures: application to acyl glucuronide intramolecular transacylation reactions.. Analytical chemistry, 80(13), 4886-4895. doi:10.1021/ac702614t

DOI
10.1021/ac702614t
Journal article

2007

Cyclization of the acyl glucuronide metabolite of a neutral endopeptidase inhibitor to an electrophilic glutarimide: synthesis, reactivity, and mechanistic analysis.

Meng, X., Maggs, J. L., Pryde, D. C., Planken, S., Jenkins, R. E., Peakman, T. M., . . . Stachulski, A. V. (2007). Cyclization of the acyl glucuronide metabolite of a neutral endopeptidase inhibitor to an electrophilic glutarimide: synthesis, reactivity, and mechanistic analysis.. Journal of medicinal chemistry, 50(24), 6165-6176. doi:10.1021/jm0706766

DOI
10.1021/jm0706766
Journal article

Investigation of the immunogenicity of diclofenac and diclofenac metabolites

Naisbitt, D. J., Sanderson, L. S., Meng, X., Stachulski, A. V., Clarke, S. E., & Park, B. K. (2007). Investigation of the immunogenicity of diclofenac and diclofenac metabolites. TOXICOLOGY LETTERS, 168(1), 45-50. doi:10.1016/j.toxlet.2006.10.014

DOI
10.1016/j.toxlet.2006.10.014
Journal article

2004

Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac.

Kenny, J. R., Maggs, J. L., Meng, X., Sinnott, D., Clarke, S. E., Park, B. K., & Stachulski, A. V. (2004). Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac.. Journal of medicinal chemistry, 47(11), 2816-2825. doi:10.1021/jm030891w

DOI
10.1021/jm030891w
Journal article