Publications
Selected publications
- Activation of Human CD8+ T Cells with Nitroso Dapsone-Modified HLA-B*13:01-Binding Peptides. (Journal article - 2023)
- Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury (Journal article - 2023)
- Shared Clavulanate and Tazobactam Antigenic Determinants Activate T-Cells from Hypersensitive Patients (Journal article - 2022)
- Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives (Journal article - 2021)
- HLA DaB1*15:01-DQB1*06:02-Restricted Human CD4+T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts (Journal article - 2020)
- Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation (Journal article - 2020)
- CDDO-imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1. (Journal article - 2020)
- Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo (Journal article - 2019)
- Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017) (Journal article - 2018)
- Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients (Journal article - 2014)
2024
CYP3A4-Mediated Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor JNJ-54861911 Results in Redox-Neutral Addition of Glutathione via Catalysis by Glutathione S-Transferase α1, Identified as the Major Target Protein in Human Hepatocytes.
Leclercq, L., de Vries, R., Koppen, V., Verboven, P., Cuyckens, F., Wynant, I., . . . Snoeys, J. (2024). CYP3A4-Mediated Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor JNJ-54861911 Results in Redox-Neutral Addition of Glutathione via Catalysis by Glutathione S-Transferase α1, Identified as the Major Target Protein in Human Hepatocytes.. Chemical research in toxicology. doi:10.1021/acs.chemrestox.4c00279
Feedback regulation of VISTA and Treg by TNF-α controls T cell responses in drug allergy.
Sun, L., Zhao, Q., Ao, S., Liu, T., Wang, Z., You, J., . . . Zhang, F. (2024). Feedback regulation of VISTA and Treg by TNF-α controls T cell responses in drug allergy.. Allergy. doi:10.1111/all.16393
Tolvaptan Safety in Autosomal Dominant Polycystic Kidney Disease; Focus on Idiosyncratic Drug Induced Liver Injury Liabilities.
Hammond, S., Meng, X., Barber, J., Mosedale, M., Chadwick, A., Watkins, P. B., & Naisbitt, D. J. (2024). Tolvaptan Safety in Autosomal Dominant Polycystic Kidney Disease; Focus on Idiosyncratic Drug Induced Liver Injury Liabilities.. Toxicological sciences : an official journal of the Society of Toxicology, kfae142. doi:10.1093/toxsci/kfae142
Selective HLA Class II Allele-Restricted Activation of Atabecestat Metabolite-Specific Human T-Cells.
Ford, M., Thomson, P. J., Snoeys, J., Meng, X., & Naisbitt, D. J. (2024). Selective HLA Class II Allele-Restricted Activation of Atabecestat Metabolite-Specific Human T-Cells.. Chemical research in toxicology, 37(10), 1712-1727. doi:10.1021/acs.chemrestox.4c00262
Development and translation of a method of clinical utility for LC-MS/MS analysis to detect SARS-CoV-2 antigens from ONP swabs and saliva
P15-06 Amoxicillin-induced liver injury: characterisation of amoxicillin-specific T-cells in healthy donors reveals unexpected HLA class I restrictions
Saville, E., Maier, C., Blackburn, J., Naisbitt, D., & Meng, X. (2024). P15-06 Amoxicillin-induced liver injury: characterisation of amoxicillin-specific T-cells in healthy donors reveals unexpected HLA class I restrictions. Toxicology Letters, 399, S230-S231. doi:10.1016/j.toxlet.2024.07.564
P15-14 Characterisation of liver-derived T-cells during and upon resolution of CFTR modulator induced liver injury
Clarke, E., Gardner, J., Gillgrass, L., Peckham, D., Meng, X., & Naisbitt, D. (2024). P15-14 Characterisation of liver-derived T-cells during and upon resolution of CFTR modulator induced liver injury. Toxicology Letters, 399, S234. doi:10.1016/j.toxlet.2024.07.572
Protein Haptenation and Its Role in Allergy.
Aleksic, M., & Meng, X. (2024). Protein Haptenation and Its Role in Allergy.. Chemical research in toxicology, 37(6), 850-872. doi:10.1021/acs.chemrestox.4c00062
Patients with <scp>naproxen‐induced</scp> liver injury display T‐cell memory responses toward an oxidative (S)‐<scp>O‐Desmethyl</scp> Naproxen metabolite but not the acyl glucuronide
Thomson, P., Fragkas, N., Kafu, L. M., Aithal, G. P., Lucena, M. I., Terracciano, L., . . . Naisbitt, D. J. (n.d.). Patients with <scp>naproxen‐induced</scp> liver injury display T‐cell memory responses toward an oxidative (S)‐<scp>O‐Desmethyl</scp> Naproxen metabolite but not the acyl glucuronide. Allergy. doi:10.1111/all.15830
Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-Desmethyl Naproxen metabolite but not the acyl glucuronide
Thomson, P., Fragkas, N., Kafu, L. M., Aithal, G. P., Lucena, M. I., Terracciano, L., . . . Naisbitt, D. J. (2023). Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-Desmethyl Naproxen metabolite but not the acyl glucuronide. In ALLERGY. doi:10.1111/all.15830
2023
Sodium valproate causes pancreatic injury in vitro and in vivo via dysregulation of one carbon metabolism
Cai, W., Chvanov, M., Awais, M., Meng, X., Latawiec, D., Brown, J., . . . Sutton, R. (2023). Sodium valproate causes pancreatic injury in vitro and in vivo via dysregulation of one carbon metabolism. Pancreatology, 23, e20-e21. doi:10.1016/j.pan.2023.06.453
HLA-C*15:02 and epidermal growth factor receptor inhibitor-induced erosive pustular dermatosis of the scalp
Zhang, Y., Grice, S., Wang, N., Liu, Y., Zhao, Q., Liu, T., . . . Zhang, F. (2023). HLA-C*15:02 and epidermal growth factor receptor inhibitor-induced erosive pustular dermatosis of the scalp. CLINICAL AND EXPERIMENTAL DERMATOLOGY. doi:10.1093/ced/llad282
A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment
Ogese, M. O., Lister, A., Farrell, L., Gardner, J., Kafu, L., Ali, S. -E., . . . Naisbitt, D. J. (2023). A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment. TOXICOLOGICAL SCIENCES. doi:10.1093/toxsci/kfad101
Why drug exposure is frequently associated with T-cell mediated cutaneous hypersensitivity reactions
Line, J., Saville, E., Meng, X., & Naisbitt, D. (2023). Why drug exposure is frequently associated with T-cell mediated cutaneous hypersensitivity reactions. FRONTIERS IN TOXICOLOGY, 5. doi:10.3389/ftox.2023.1268107
What’s been Hapten-ing over the last 88 years?
Thomson, P., Hammond, S., Meng, X., & Naisbitt, D. J. (n.d.). What’s been Hapten-ing over the last 88 years?. Medicinal Chemistry Research. doi:10.1007/s00044-023-03091-1
Activation of Human CD8+ T Cells with Nitroso Dapsone-Modified HLA-B*13:01-Binding Peptides.
Almutairi, M., Lister, A., Zhao, Q., Line, J., Adair, K., Tailor, A., . . . Naisbitt, D. J. (2023). Activation of Human CD8+ T Cells with Nitroso Dapsone-Modified HLA-B*13:01-Binding Peptides.. Journal of immunology (Baltimore, Md. : 1950), 210(8), 1031-1042. doi:10.4049/jimmunol.2200531
Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System
Ali, S. -E., Meng, X., Kafu, L., Hammond, S., Zhao, Q., Ogese, M., . . . Naisbitt, D. J. (2023). Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System. CHEMICAL RESEARCH IN TOXICOLOGY, 36(3), 390-401. doi:10.1021/acs.chemrestox.2c00343
Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury
Ali, S. -E., Waddington, J. C., Lister, A., Sison-Young, R., Jones, R. P., Rehman, A. H., . . . Meng, X. (2023). Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury. TOXICOLOGICAL SCIENCES, 192(1), 106-116. doi:10.1093/toxsci/kfad015
Activation of tolvaptan-responsive T-cell clones with the structurally-related mozavaptan
Hammond, S., Meng, X., Mosedale, M., & Naisbitt, D. J. (2023). Activation of tolvaptan-responsive T-cell clones with the structurally-related mozavaptan. Toxicology Letters, 373, 148-151. doi:10.1016/j.toxlet.2022.11.017
2022
Shared Clavulanate and Tazobactam Antigenic Determinants Activate T-Cells from Hypersensitive Patients
Ariza, A., Jaruthamsophon, K., Meng, X., Labella, M., Adair, K., Tailor, A., . . . Naisbitt, D. J. (2022). Shared Clavulanate and Tazobactam Antigenic Determinants Activate T-Cells from Hypersensitive Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 35(11), 2122-2132. doi:10.1021/acs.chemrestox.2c00231
Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity
Hammond, S., Olsson-Brown, A., Grice, S., Gibson, A., Gardner, J., Castrejon-Flores, J. L., . . . Naisbitt, D. J. (2022). Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity. TOXICOLOGICAL SCIENCES, 186(1), 58-69. doi:10.1093/toxsci/kfab144
2021
HLA Class-II. Restricted CD8<SUP>+</SUP> T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients
Zhao, Q., Almutairi, M., Tailor, A., Lister, A., Harper, N., Line, J., . . . Naisbitt, D. J. (2021). HLA Class-II. Restricted CD8<SUP>+</SUP> T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 141(10), 2412-+. doi:10.1016/j.jid.2021.03.014
Drug hapten-specific T-cell activation: Current status and unanswered questions
Adair, K., Meng, X., & Naisbitt, D. J. (2021). Drug hapten-specific T-cell activation: Current status and unanswered questions. PROTEOMICS, 21(17-18). doi:10.1002/pmic.202000267
Deciphering Adverse Drug Reactions: <i>In Vitro</i> Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01
Ogese, M. O., Lister, A., Gardner, J., Meng, X., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2021). Deciphering Adverse Drug Reactions: <i>In Vitro</i> Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01. TOXICOLOGICAL SCIENCES, 183(1), 139-153. doi:10.1093/toxsci/kfab084
Drug-specific T-cell responses in patients with liver injury following treatment with the BACE inhibitor atabecestat
Thomson, P. J., Kafu, L., Meng, X., Snoeys, J., De Bondt, A., De Maeyer, D., . . . Naisbitt, D. J. (2021). Drug-specific T-cell responses in patients with liver injury following treatment with the BACE inhibitor atabecestat. ALLERGY, 76(6), 1825-1835. doi:10.1111/all.14652
Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine
Yip, V. L. M., Pertinez, H., Meng, X., Maggs, J. L., Carr, D. F., Park, B. K., . . . Pirmohamed, M. (2021). Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(6), 2572-2588. doi:10.1111/bcp.14667
Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives
Amporndanai, K., Meng, X., Shang, W., Jin, Z., Zhao, Y., Rao, Z., . . . Rogers, M. (2021). Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-23313-7
In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs
Naisbitt, D. (2021). In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs. Frontiers in Immunology. doi:10.3389/fimmu.2021.630530
Novel inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives
2020
Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury
Waddington, J. C., Ali, S. -E., Penman, S. L., Whitaker, P., Hamlett, J., Chadwick, A., . . . Meng, X. (2020). Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 33(12), 2939-2943. doi:10.1021/acs.chemrestox.0c00400
Characterization of Clozapine-Responsive Human T Cells
Ogese, M. O., Lister, A., Jenkins, R. E., Meng, X., Alfirevic, A., Douglas, L., . . . Naisbitt, D. J. (2020). Characterization of Clozapine-Responsive Human T Cells. JOURNAL OF IMMUNOLOGY, 205(9), 2375-+. doi:10.4049/jimmunol.2000646
HLA DaB1*15:01-DQB1*06:02-Restricted Human CD4+T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts
Tailor, A., Meng, X., Adair, K., Farrell, J., Waddington, J. C., Daly, A., . . . Naisbitt, D. J. (2020). HLA DaB1*15:01-DQB1*06:02-Restricted Human CD4+T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts. TOXICOLOGICAL SCIENCES, 178(1), 115-126. doi:10.1093/toxsci/kfaa128
Characterization of amoxicillin and clavulanic acid specific T-cell clones from patients with immediate drug hypersensitivity
Ariza, A., Fernandez-Santamaria, R., Meng, X., Salas, M., Ogese, M. O., Tailor, A., . . . Naisbitt, D. J. (2020). Characterization of amoxicillin and clavulanic acid specific T-cell clones from patients with immediate drug hypersensitivity. ALLERGY, 75(10), 2562-2573. doi:10.1111/all.14298
Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation
Waddington, J. C., Meng, X., Illing, P. T., Tailor, A., Adair, K., Whitaker, P., . . . Park, B. K. (2020). Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation. TOXICOLOGICAL SCIENCES, 177(2), 454-465. doi:10.1093/toxsci/kfaa124
Safety perspectives on presently considered drugs for the treatment of COVID‐19
Penman, S. L., Kiy, R. T., Jensen, R. L., Beoku‐Betts, C., Alfirevic, A., Back, D., . . . Chadwick, A. E. (n.d.). Safety perspectives on presently considered drugs for the treatment of COVID‐19. British Journal of Pharmacology. doi:10.1111/bph.15204
CDDO-imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1.
Meng, X., Waddington, J. C., Tailor, A., Lister, A., Hamlett, J., Berry, N., . . . Sporn, M. B. (2020). CDDO-imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1. JOURNAL OF MEDICINAL CHEMISTRY, 63(17), 9965-9976. doi:10.1021/acs.jmedchem.0c01088
Safety perspectives on presently considered drugs for the treatment of COVID-19
Immune dysregulation increases the incidence of delayed-type drug hypersensitivity reactions
Naisbitt, D. J., Olsson-Brown, A., Gibson, A., Meng, X., Ogese, M. O., Tailor, A., & Thomson, P. (2020). Immune dysregulation increases the incidence of delayed-type drug hypersensitivity reactions. ALLERGY, 75(4), 781-797. doi:10.1111/all.14127
Definition of the Chemical and Immunological Signals Involved in Drug-Induced Liver Injury
Ali, S. -E., Waddington, J. C., Park, B. K., & Meng, X. (2020). Definition of the Chemical and Immunological Signals Involved in Drug-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 33(1), 61-76. doi:10.1021/acs.chemrestox.9b00275
2019
Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system.
Ogese, M. O., Jenkins, R. E., Adair, K., Tailor, A., Meng, X., Faulkner, L. L., . . . Betts, C. (2019). Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system.. Hepatology, 70(5), 1732-1749. doi:10.1002/hep.30701
Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo
Tailor, A., Waddington, J. C., Hamlett, J., Maggs, J., Kafu, L., Farrell, J., . . . Meng, X. (2019). Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo. CHEMICAL RESEARCH IN TOXICOLOGY, 32(10), 2095-2106. doi:10.1021/acs.chemrestox.9b00282
Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01
Zhao, Q., Alhilali, K., Alzahrani, A., Almutairi, M., Amjad, J., Liu, H., . . . Naisbitt, D. J. (2019). Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01. Allergy, 74(8), 1533-1548. doi:10.1111/all.13769
Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers
Alhilali, K. A., Al-Attar, Z., Gibson, A., Tailor, A., Meng, X., Monshouwer, M., . . . Naisbitt, D. J. (2019). Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers. TOXICOLOGICAL SCIENCES, 168(2), 597-609. doi:10.1093/toxsci/kfz007
Beta-lactam protein binding leads to the presentation of novel MHC peptides, generating a potential immunogen for drug-hypersensitive reactions
Waddington, J., Meng, X., Illing, P., Tailor, A., Jenkins, R., Purcell, A., . . . Park, B. (2019). Beta-lactam protein binding leads to the presentation of novel MHC peptides, generating a potential immunogen for drug-hypersensitive reactions. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 176 (pp. 3004-3005). Retrieved from https://www.webofscience.com/
2018
HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors
Usui, T., Tailor, A., Faulkner, L., Meng, X., Farrell, J., Daly, A. K., . . . Naisbitt, D. J. (2018). HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 31(10), 1022-1024. doi:10.1021/acs.chemrestox.8b00163
Immune drug-induced liver disease and drugs
Waddington, J. C., Meng, X., Naisbitt, D. J., & Park, B. K. (2018). Immune drug-induced liver disease and drugs. Current Opinion in Toxicology, 10, 46-53. doi:10.1016/j.cotox.2017.12.006
Mechanisms leading to T-cell activation in drug hypersensitivity
Meng, X., Yerly, D., & Naisbitt, D. J. (2018). Mechanisms leading to T-cell activation in drug hypersensitivity. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 18(4), 317-324. doi:10.1097/ACI.0000000000000458
Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017)
Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2018). Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1952. doi:10.4049/jimmunol.1800020
2017
Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts
Amali, M. O., Jenkins, R. E., Meng, X., Faulkner, L., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2017). Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2097-2099. doi:10.1021/acs.chemrestox.7b00291
Dapsone and Nitroso Dapsone Activation of Naı̈ve T-Cells from Healthy Donors.
Alzahrani, A., Ogese, M., Meng, X., Waddington, J. C., Tailor, A., Farrell, J., . . . Naisbitt, D. (2017). Dapsone and Nitroso Dapsone Activation of Naive T-Cells from Healthy Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2174-2186. doi:10.1021/acs.chemrestox.7b00263
Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients
Yip, V. L. M., Meng, X., Maggs, J. L., Jenkins, R., Marlot, P., Marson, A., . . . Pirmohamed, M. (2017). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients. Chemical Research in Toxicology, 30(7), 1419-1435. doi:10.1021/acs.chemrestox.7b00063
Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients.
Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2017). Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients.. Journal of Immunology, 198(11), 4217-4227. doi:10.4049/jimmunol.1700209
Detection of drug-responsive B lymphocytes and antidrug IgG in patients with β-lactam hypersensitivity
Amali, M. O., Sullivan, A., Jenkins, R. E., Farrell, J., Meng, X., Faulkner, L., . . . Naisbitt, D. J. (2017). Detection of drug-responsive B lymphocytes and antidrug IgG in patients with β-lactam hypersensitivity. ALLERGY, 72(6), 896-907. doi:10.1111/all.13087
From the Cover: Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury.
Usui, T., Meng, X., Saide, K., Farrell, J., Thomson, P., Whitaker, P., . . . Naisbitt, D. J. (2017). Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury. TOXICOLOGICAL SCIENCES, 155(2), 420-431. doi:10.1093/toxsci/kfw218
Immunological Mechanisms of Drug Hypersensitivity
Meng, X., Ariza, A., Waddington, J., Park, K., & Naisbitt, D. (2016). Immunological Mechanisms of Drug Hypersensitivity. CURRENT PHARMACEUTICAL DESIGN, 22(45), 6734-6747. doi:10.2174/1381612822666161003115103
New Approaches to Investigate Drug-Induced Hypersensitivity
Ogese, M. O., Ahmed, S., Alferivic, A., Betts, C. J., Dickinson, A., Faulkner, L., . . . Naisbitt, D. J. (2017). New Approaches to Investigate Drug-Induced Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 30(1), 239-259. doi:10.1021/acs.chemrestox.6b00333
2016
Mass Spectrometric and Functional Aspects of Drug-Protein Conjugation
Tailor, A., Waddington, J. C., Meng, X., & Park, B. K. (2016). Mass Spectrometric and Functional Aspects of Drug-Protein Conjugation. CHEMICAL RESEARCH IN TOXICOLOGY, 29(12), 1912-1935. doi:10.1021/acs.chemrestox.6b00147
No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with HLA-DRB1*07:01-Restricted Lapatinib-Induced Liver Injury
Faulkner, L., Meng, X., Naisbitt, D. J., Spraggs, C. F., & Park, B. K. (2016). No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with <i>HLA</i>-<i>DRB1</i>*07:01-Restricted Lapatinib-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 29(12), 2111-2113. doi:10.1021/acs.chemrestox.6b00400
A combination of clinical and genetic covariates significantly influence the metabolism of carbamazepine: potential implications for carbamazepine hypersensitivity
Yip, V. L. M., Meng, X., Maggs, J. L., Pertinez, H., Carr, D. F., Marson, A. G., . . . Pirmohamed, M. (2016). A combination of clinical and genetic covariates significantly influence the metabolism of carbamazepine: potential implications for carbamazepine hypersensitivity. London, UK.
Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury
Usui, T., Whitaker, P., Meng, X., Watson, J., Antoine, D. J., French, N. S., . . . Naisbitt, D. J. (2016). Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 29(11), 1793-1795. doi:10.1021/acs.chemrestox.6b00393
Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients
Meng, X., Earnshaw, C. J., Tailor, A., Jenkins, R. E., Waddington, J. C., Whitaker, P., . . . Park, B. K. (2016). Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 29(10), 1762-1772. doi:10.1021/acs.chemrestox.6b00253
7th drug hypersensitivity meeting: part one
Carr, D. F., Chung, W. -H., Jenkiins, R. E., Chaponda, M., Nwikue, G., Cornejo Castro, E. M., . . . Ruano, F. J. (2016). 7th drug hypersensitivity meeting: part one. Clinical and Translational Allergy, 6(S3). doi:10.1186/s13601-016-0121-z
2015
Promiscuous T-cell responses to drugs and drug-haptens
Yaseen, F. S., Saide, K., Kim, S. -H., Monshi, M., Tailor, A., Wood, S., . . . Naisbitt, D. J. (2015). Promiscuous T-cell responses to drugs and drug-haptens. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136(2), 474-+. doi:10.1016/j.jaci.2015.02.036
Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin
Meng, X., Maggs, J. L., Usui, T., Whitaker, P., French, N. S., Naisbitt, D. J., & Park, B. K. (2015). Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin. Chemical Research in Toxicology, 28(1), 51-58. doi:10.1021/tx500285k
Characterization of Peroxidases Expressed in Human AntigenPresenting Cells and Analysis of the Covalent Binding of NitrosoSulfamethoxazole to Myeloperoxidase
Ogese, M. O., Jenkins,, R. E., Maggs, J. L., Meng, X., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2015). Characterization of Peroxidases Expressed in Human AntigenPresenting Cells and Analysis of the Covalent Binding of NitrosoSulfamethoxazole to Myeloperoxidase. Chemical Research in Toxicology, 28(1), 144-154. doi:10.1021/tx500458k
2014
Abacavir forms novel cross-linking abacavir protein adducts in patients
Meng, X., Lawrenson, A., Berry, N., Maggs, J., French, N., Back, D., . . . Park, K. (2014). Abacavir forms novel cross-linking abacavir protein adducts in patients. Clinical and translational allergy, 4(Suppl 3), P38. doi:10.1186/2045-7022-4-s3-p38
Antigen exposure required for T cell activation
Meng, X., Yaseen, F., Earnshaw, C., Jenkins, R., Peckham, D., Whitaker, P., . . . Park, K. (2014). Antigen exposure required for T cell activation. Clinical and translational allergy, 4(Suppl 3), P115. doi:10.1186/2045-7022-4-s3-p115
Characterization of anti-drug antibodies and drug-responsive B-lymphocytes in piperacillin hypersensitive patients with cystic fibrosis
Amali, M., Sullivan, A., Farrell, J., Meng, X., Jenkins, R., Whitaker, P., . . . Naisbitt, D. J. (2014). Characterization of anti-drug antibodies and drug-responsive B-lymphocytes in piperacillin hypersensitive patients with cystic fibrosis. Clinical and translational allergy, 4(Suppl 3), P113. doi:10.1186/2045-7022-4-s3-p113
Isoniazid-specific T-cell Responses in patients with anti-tuberculosis drug related liver injury
Usui, T., Saide, K., Meng, X., Whitaker, P., Peckham, D., French, N., . . . Park, K. (2014). Isoniazid-specific T-cell Responses in patients with anti-tuberculosis drug related liver injury. Clinical and translational allergy, 4(Suppl 3), P116. doi:10.1186/2045-7022-4-s3-p116
Abacavir forms novel cross-linking abacavir protein adducts in patients
Meng, X., Lawrenson, A. S., Berry, N. G., Maggs, J. L., French, N. S., Back, D. J., . . . Park, B. K. (2014). Abacavir forms novel cross-linking abacavir protein adducts in patients. Chemical Research in Toxicology, 27(04), 524-535. doi:10.1021/tx400406p
Covalent adduction of carbamazepine 10, 11-epoxide with human serum albumin and glutathione S-transferase pi: implications for carbamazepine hypersensitivity
Yip, V., Maggs, J., Meng, X., Marson, A., Park, K., & Pirmohamed, M. (2014). Covalent adduction of carbamazepine 10, 11-epoxide with human serum albumin and glutathione S-transferase pi: implications for carbamazepine hypersensitivity. LANCET, 383, 114. Retrieved from https://www.webofscience.com/
Dissecting the reaction of Phase II metabolites of ibuprofen and other NSAIDS with human plasma protein
Monrad, R. N., Errey, J. C., Barry, C. S., Iqbal, M., Meng, X., Iddon, L., . . . Davis, B. G. (2014). Dissecting the reaction of Phase II metabolites of ibuprofen and other NSAIDS with human plasma protein. CHEMICAL SCIENCE, 5(10), 3789-3794. doi:10.1039/c4sc01329h
Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients
Hammond, T. G., Meng, X., Jenkins, R. E., Maggs, J. L., Castelazo, A. S., Regan, S. L., . . . Williams, D. P. (2014). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 350(2), 387-402. doi:10.1124/jpet.114.215079
The importance of hapten - protein complex formation in the development of drug allergy
Faulkner, L., Meng, X., Park, B. K., & Naisbitt, D. J. (2014). The importance of hapten - protein complex formation in the development of drug allergy. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 14(4), 293-300. doi:10.1097/ACI.0000000000000078
2013
β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis
Jenkins, R. E., Yaseen, F. S., Monshi, M. M., Whitaker, P., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2013). β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis. CHEMICAL RESEARCH IN TOXICOLOGY, 26(6), 963-975. doi:10.1021/tx400124m
Glucuronides from metabolites to medicines: a survey of the in vivo generation, chemical synthesis and properties of glucuronides.
Stachulski, A. V., & Meng, X. (2013). Glucuronides from metabolites to medicines: a survey of the in vivo generation, chemical synthesis and properties of glucuronides.. Natural product reports, 30(6), 806-848. doi:10.1039/c3np70003h
Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients
Meng, X., Howarth, A., Earnshaw, C. J., Jenkins, R. E., French, N. S., Back, D. J., . . . Park, B. K. (2013). Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 26(4), 575-583. doi:10.1021/tx4000107
2012
Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis
El-Ghaiesh, S., Monshi, M. M., Whitaker, P., Jenkins, R., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 341(3), 597-610. doi:10.1124/jpet.111.190900
2011
In vitro assessment of the interactions between diclofenac and tolmetin acyl glucuronide drug metabolites and human serum albumin
Hammond, T. G., Regan, S. L., Meng, X., Maggs, J. L., Jenkins, R. E., Kenna, J. G., . . . Park, B. K. (2011). In vitro assessment of the interactions between diclofenac and tolmetin acyl glucuronide drug metabolites and human serum albumin. Toxicology, 290(2-3), 142-143. doi:10.1016/j.tox.2011.09.072
Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients
Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 338(3), 841-849. doi:10.1124/jpet.111.183871
Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients
Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. Journal of Pharmacology and Experimental Therapeutics, 338(3), 841-849. doi:10.1124/jpet.111.183871
Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis
Whitaker, P., Meng, X., Lavergne, S. N., El-Ghaiesh, S., Monshi, M., Earnshaw, C., . . . Park, B. K. (2011). Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis. J Immunol, 187(1), 200-211.
2010
Protein binding and pharmacokinetics of reactive acyl glucuronide drug metabolites
Hammond, T. G., Regan, S. L., Meng, X., Maggs, J. L., Jenkins, R. E., Kenna, G. L., . . . Park, B. K. (2010). Protein binding and pharmacokinetics of reactive acyl glucuronide drug metabolites. Toxicology, 278(3), 357-358. doi:10.1016/j.tox.2010.08.108
High-performance liquid chromatography/mass spectrometric and proton nuclear magnetic resonance spectroscopic studies of the transacylation and hydrolysis of the acyl glucuronides of a series of phenylacetic acids in buffer and human plasma.
Karlsson, E. S., Johnson, C. H., Sarda, S., Iddon, L., Iqbal, M., Meng, X., . . . Lindon, J. C. (2010). High-performance liquid chromatography/mass spectrometric and proton nuclear magnetic resonance spectroscopic studies of the transacylation and hydrolysis of the acyl glucuronides of a series of phenylacetic acids in buffer and human plasma.. Rapid communications in mass spectrometry : RCM, 24(20), 3043-3051. doi:10.1002/rcm.4740
Integrated HPLC-MS and (1)H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides.
Johnson, C. H., Karlsson, E., Sarda, S., Iddon, L., Iqbal, M., Meng, X., . . . Lindon, J. C. (2010). Integrated HPLC-MS and (1)H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides.. Xenobiotica; the fate of foreign compounds in biological systems, 40(1), 9-23. doi:10.3109/00498250903348720
2009
Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA <i>in vitro</i> and <i>in vivo</i>
Jenkins, R. E., Meng, X., Elliott, V. L., Kitteringham, N. R., Pirmohamed, M., & Park, B. K. (2009). Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA <i>in vitro</i> and <i>in vivo</i>. PROTEOMICS CLINICAL APPLICATIONS, 3(6), 720-729. doi:10.1002/prca.200800222
Convenient syntheses of the in vivo carbohydrate metabolites of mycophenolic acid: reactivity of the acyl glucuronide
Jones, A. E., Wilson, H. K., Meath, P., Meng, X., Holt, D. W., Johnston, A., . . . Stachulski, A. V. (2009). Convenient syntheses of the in vivo carbohydrate metabolites of mycophenolic acid: reactivity of the acyl glucuronide. Tetrahedron Letters, 50(35), 4973-4977. doi:10.1016/j.tetlet.2009.06.060
Synthesis, transacylation kinetics and computational chemistry of a set of arylacetic acid 1β-<i>O</i>-acyl glucuronides
Berry, N. G., Iddon, L., Iqbal, M., Meng, X., Jayapal, P., Johnson, C. H., . . . Stachulski, A. V. (2009). Synthesis, transacylation kinetics and computational chemistry of a set of arylacetic acid 1β-<i>O</i>-acyl glucuronides. ORGANIC & BIOMOLECULAR CHEMISTRY, 7(12), 2525-2533. doi:10.1039/b822777b
2008
Kinetic and J-resolved statistical total correlation NMR spectroscopy approaches to structural information recovery in complex reacting mixtures: application to acyl glucuronide intramolecular transacylation reactions.
Johnson, C. H., Athersuch, T. J., Wilson, I. D., Iddon, L., Meng, X., Stachulski, A. V., . . . Nicholson, J. K. (2008). Kinetic and J-resolved statistical total correlation NMR spectroscopy approaches to structural information recovery in complex reacting mixtures: application to acyl glucuronide intramolecular transacylation reactions.. Analytical chemistry, 80(13), 4886-4895. doi:10.1021/ac702614t
2007
Cyclization of the acyl glucuronide metabolite of a neutral endopeptidase inhibitor to an electrophilic glutarimide: synthesis, reactivity, and mechanistic analysis.
Meng, X., Maggs, J. L., Pryde, D. C., Planken, S., Jenkins, R. E., Peakman, T. M., . . . Stachulski, A. V. (2007). Cyclization of the acyl glucuronide metabolite of a neutral endopeptidase inhibitor to an electrophilic glutarimide: synthesis, reactivity, and mechanistic analysis.. Journal of medicinal chemistry, 50(24), 6165-6176. doi:10.1021/jm0706766
Investigation of the immunogenicity of diclofenac and diclofenac metabolites
Naisbitt, D. J., Sanderson, L. S., Meng, X., Stachulski, A. V., Clarke, S. E., & Park, B. K. (2007). Investigation of the immunogenicity of diclofenac and diclofenac metabolites. TOXICOLOGY LETTERS, 168(1), 45-50. doi:10.1016/j.toxlet.2006.10.014
2004
Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac.
Kenny, J. R., Maggs, J. L., Meng, X., Sinnott, D., Clarke, S. E., Park, B. K., & Stachulski, A. V. (2004). Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac.. Journal of medicinal chemistry, 47(11), 2816-2825. doi:10.1021/jm030891w