Research
Research Interest 1
Pancreatic cancer
Pancreatitis
Hsp90
Yeast
Research grants
Molecular characterisation of the interaction between gemcitabine and capecitabine in the treatment of pancreatic cancer
WELLCOME TRUST (UK)
July 2015 - September 2015
Clinical validation of a serum protein biomarker signature for the early diagnosis of pancreatic cancer
IMMUNOVIA AB (SWEDEN)
January 2016 - December 2020
Creating a rapid diagnostic pathway for patients with pancreatic cancer
PANCREATIC CANCER UK (UK)
October 2014 - September 2017
Pathos-T: A Bioresource Collection associated with PATHOS, a Phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV)-positive oropharyngeal cancer
CANCER RESEARCH UK (UK)
November 2015 - December 2025
Liverpool ECMC (LECMC)
CANCER RESEARCH UK (UK), DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
April 2023 - March 2028
A randomized, placebo-controlled, double-blinded trial of the safety and efficacy of tecovirimat for the treatment of non-hospitalised patients with monkeypox virus disease
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
July 2022 - December 2023
A modular, multi-arm, first in human trial to evaluate the safety and tolerability of MDX-124 alone and in combination with anti-cancer treatments, in subjects with locally advanced, unresectable or metastatic solid malignancies
MEDANNEX LIMITED (UK)
June 2022 - April 2027
Exploratory analysis of the association between Cox-2 expression and primary resistance to check-point inhibitor therapy for cancer (COX2)
THE CLATTERBRIDGE CANCER CENTRE NHS FOUNDATION TRUST (UK)
May 2020 - January 2026
Application of deep proteomics using an aptamer-based technology to advance early detection of pancreatic cancer
CANCER RESEARCH UK (UK)
September 2019 - June 2022
Prospective evaluation of urinary biomarker panel for early detection of pancreatic adenocarcinoma
PANCREATIC CANCER RESEARCH FUND (UK)
March 2019 - August 2026
Growing and Embedding Open Research in Institutional Practice and Culture
RESEARCH ENGLAND (UK)
September 2021 - August 2026
Assessing druGs for COVID19 In early cLinical phase Expeditiously (AGILE)
GLAXOSMITHKLINE (UK)
January 2021 - December 2022
Dissecting the biology underpinning pancreatic cancer-associated diabetes
PANCREATIC CANCER UK (UK)
September 2021 - September 2024
Post-hospitalisation COVID-19 study: a national consortium to understand and improve long-term health outcomes (PHOSP-COVID)
MEDICAL RESEARCH COUNCIL
June 2021 - June 2023
CCP–CANCER UK: Clinical Characterisation Protocol for Severe Emerging Infections in the UK (CCP-UK) – a prospective companion study for patients with Cancer and COVID-19.
MEDICAL RESEARCH COUNCIL, THE CLATTERBRIDGE CANCER CHARITY (UK)
June 2020 - April 2024
Integrating biomarkers to stratify adjuvant chemotherapy in pancreatic cancer patients
NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)
January 2019 - August 2022
Preclinical evaluation of Nrf2 inhibition as a means to improve chemotherapeutic efficacy in patients with pancreatic cancer
PANCREATIC CANCER RESEARCH FUND (UK)
February 2016 - January 2020
Sample collection from individuals with new-onset diabetes and validation of potential blood-borne biomarkers to enable earlier detection of pancreatic cancer in this high-risk group
PANCREATIC CANCER ACTION (UK)
January 2016 - April 2020
Cancer Apoptosis by Specific Inhibition of Hsp90.
WORLDWIDE CANCER RESEARCH (UK)
April 2001 - June 2004
ESPAC 4 Prospective sample collection - ESPAC 4T
CANCER RESEARCH UK (UK)
September 2010 - November 2017
Combined Genetic and Proteomic Screening for early Detection of Pancreatic Cancer.
CANCER RESEARCH UK (UK)
October 2007 - September 2011
Novel molecular diagnostic tools for the prevention and diagnosis of pancreatic cancer.
EUROPEAN COMMISSION
August 2006 - January 2010
Validation of serum biomarkers for pancreatic cancer detection
NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)
October 2013 - June 2016
Can protein profiling enable screening of newly diagnosed diabetics for pancreatic cancer?
PANCREATIC CANCER UK (UK)
October 2013 - November 2014
Stratification of adjuvant chemotherapeutic response to allow personalised choice of pyrimidine prodrug: based on levels of transporters and enzymes involved in initial metabolism
CANCER RESEARCH UK (UK)
November 2013 - April 2017
Bridge funding for research technician within GCLP
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
March 2015 - August 2015
Identification of genes responsible for familial pancreatic cancer.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
January 2003 - December 2004
European Study Group for Pancreatic Cancer Trial 5F prospective sample collection - ESPAC-5FT
CANCER RESEARCH UK (UK)
September 2014 - December 2018
Cell separation device.
ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL
June 2008 - May 2010
Tissue sample collection from the ESPAC Adjuvant Trials in pancreatic cancer
CANCER RESEARCH UK (UK)
January 2007 - August 2010
Familial pancreatic cancer gene discovery.
CANCER RESEARCH UK (UK)
September 2002 - November 2003
Development of Screening Systems for Novel HSP90 Antagonists.
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
May 2000 - May 2003
Identification of mutations predisposing to pancreatic cancer.
CANCER RESEARCH UK (UK)
October 2005 - September 2007
Risk stratification: modelling and accessibility
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
June 2010 - May 2011
Identification of the genes involved in familial pancreatic cancer.
CLATTERBRIDGE CANCER RESEARCH
October 2002 - September 2006
Age, Methylation and Pancreas Cancer.
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
January 2002 - June 2004
Targeting the tumour microenvironment to improve pancreatic cancer prognosis - EPC-TM-Net (European Pancreatic Cancer-Tumour-Microenvironment Network)
EUROPEAN COMMISSION
February 2011 - July 2014
Evaluating and combining serum biomarkers for early pancreatic cancer detection
PANCREATIC CANCER UK (UK)
August 2011 - March 2015
Identification and validation of serum biomarkers of pancreatic cancer.
CANCER RESEARCH UK (UK)
March 2009 - March 2013
High Affinity Method to Automate Circulating Tumour Cells Capture (CTCs) from Whole blood; a Revolutionary Technology in Cancer Detection and Monitoring
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
October 2012 - June 2016
Research collaborations
Hsp90 Research
Research on Hsp90 as a novel drug target