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Research

Research Interest 1

Pancreatic cancer
Pancreatitis
Hsp90
Yeast

Research grants

Molecular characterisation of the interaction between gemcitabine and capecitabine in the treatment of pancreatic cancer

WELLCOME TRUST (UK)

July 2015 - September 2015

Clinical validation of a serum protein biomarker signature for the early diagnosis of pancreatic cancer

IMMUNOVIA AB (SWEDEN)

January 2016 - December 2020

Creating a rapid diagnostic pathway for patients with pancreatic cancer

PANCREATIC CANCER UK (UK)

October 2014 - September 2017

Pathos-T: A Bioresource Collection associated with PATHOS, a Phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV)-positive oropharyngeal cancer

CANCER RESEARCH UK (UK)

November 2015 - December 2025

Liverpool ECMC (LECMC)

CANCER RESEARCH UK (UK), DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

April 2023 - March 2028

A randomized, placebo-controlled, double-blinded trial of the safety and efficacy of tecovirimat for the treatment of non-hospitalised patients with monkeypox virus disease

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

July 2022 - December 2023

A modular, multi-arm, first in human trial to evaluate the safety and tolerability of MDX-124 alone and in combination with anti-cancer treatments, in subjects with locally advanced, unresectable or metastatic solid malignancies

MEDANNEX LIMITED (UK)

June 2022 - April 2027

Exploratory analysis of the association between Cox-2 expression and primary resistance to check-point inhibitor therapy for cancer (COX2)

THE CLATTERBRIDGE CANCER CENTRE NHS FOUNDATION TRUST (UK)

May 2020 - July 2025

Application of deep proteomics using an aptamer-based technology to advance early detection of pancreatic cancer

CANCER RESEARCH UK (UK)

September 2019 - June 2022

Prospective evaluation of urinary biomarker panel for early detection of pancreatic adenocarcinoma

PANCREATIC CANCER RESEARCH FUND (UK)

March 2019 - August 2026

Growing and Embedding Open Research in Institutional Practice and Culture

RESEARCH ENGLAND (UK)

September 2021 - August 2026

Assessing druGs for COVID19 In early cLinical phase Expeditiously (AGILE)

GLAXOSMITHKLINE (UK)

January 2021 - December 2022

Dissecting the biology underpinning pancreatic cancer-associated diabetes

PANCREATIC CANCER UK (UK)

September 2021 - September 2024

Post-hospitalisation COVID-19 study: a national consortium to understand and improve long-term health outcomes (PHOSP-COVID)

MEDICAL RESEARCH COUNCIL

June 2021 - June 2023

CCP–CANCER UK: Clinical Characterisation Protocol for Severe Emerging Infections in the UK (CCP-UK) – a prospective companion study for patients with Cancer and COVID-19.

MEDICAL RESEARCH COUNCIL, THE CLATTERBRIDGE CANCER CHARITY (UK)

June 2020 - April 2024

Integrating biomarkers to stratify adjuvant chemotherapy in pancreatic cancer patients

NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

January 2019 - August 2022

Preclinical evaluation of Nrf2 inhibition as a means to improve chemotherapeutic efficacy in patients with pancreatic cancer

PANCREATIC CANCER RESEARCH FUND (UK)

February 2016 - January 2020

Sample collection from individuals with new-onset diabetes and validation of potential blood-borne biomarkers to enable earlier detection of pancreatic cancer in this high-risk group

PANCREATIC CANCER ACTION (UK)

January 2016 - April 2020

Cancer Apoptosis by Specific Inhibition of Hsp90.

WORLDWIDE CANCER RESEARCH (UK)

April 2001 - June 2004

ESPAC 4 Prospective sample collection - ESPAC 4T

CANCER RESEARCH UK (UK)

September 2010 - November 2017

Combined Genetic and Proteomic Screening for early Detection of Pancreatic Cancer.

CANCER RESEARCH UK (UK)

October 2007 - September 2011

Novel molecular diagnostic tools for the prevention and diagnosis of pancreatic cancer.

EUROPEAN COMMISSION

August 2006 - January 2010

Validation of serum biomarkers for pancreatic cancer detection

NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

October 2013 - June 2016

Can protein profiling enable screening of newly diagnosed diabetics for pancreatic cancer?

PANCREATIC CANCER UK (UK)

October 2013 - November 2014

Stratification of adjuvant chemotherapeutic response to allow personalised choice of pyrimidine prodrug: based on levels of transporters and enzymes involved in initial metabolism

CANCER RESEARCH UK (UK)

November 2013 - April 2017

Bridge funding for research technician within GCLP

ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

March 2015 - August 2015

Identification of genes responsible for familial pancreatic cancer.

ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

January 2003 - December 2004

European Study Group for Pancreatic Cancer Trial 5F prospective sample collection - ESPAC-5FT

CANCER RESEARCH UK (UK)

September 2014 - December 2018

Cell separation device.

ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL

June 2008 - May 2010

Tissue sample collection from the ESPAC Adjuvant Trials in pancreatic cancer

CANCER RESEARCH UK (UK)

January 2007 - August 2010

Familial pancreatic cancer gene discovery.

CANCER RESEARCH UK (UK)

September 2002 - November 2003

Development of Screening Systems for Novel HSP90 Antagonists.

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

May 2000 - May 2003

Identification of mutations predisposing to pancreatic cancer.

CANCER RESEARCH UK (UK)

October 2005 - September 2007

Risk stratification: modelling and accessibility

ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

June 2010 - May 2011

Identification of the genes involved in familial pancreatic cancer.

CLATTERBRIDGE CANCER RESEARCH

October 2002 - September 2006

Age, Methylation and Pancreas Cancer.

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

January 2002 - June 2004

Targeting the tumour microenvironment to improve pancreatic cancer prognosis - EPC-TM-Net (European Pancreatic Cancer-Tumour-Microenvironment Network)

EUROPEAN COMMISSION

February 2011 - July 2014

Evaluating and combining serum biomarkers for early pancreatic cancer detection

PANCREATIC CANCER UK (UK)

August 2011 - March 2015

Identification and validation of serum biomarkers of pancreatic cancer.

CANCER RESEARCH UK (UK)

March 2009 - March 2013

High Affinity Method to Automate Circulating Tumour Cells Capture (CTCs) from Whole blood; a Revolutionary Technology in Cancer Detection and Monitoring

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

October 2012 - June 2016

    Research collaborations

    Hsp90 Research

    Research on Hsp90 as a novel drug target