Publications
2024
Role of Transporters and Enzymes in Metabolism and Distribution of 4-Chlorokynurenine (AV-101).
Patel, W., Shankar, R. G., Smith, M. A., Snodgrass, H. R., Pirmohamed, M., Jorgensen, A. L., . . . Dickens, D. (2024). Role of Transporters and Enzymes in Metabolism and Distribution of 4-Chlorokynurenine (AV-101).. Molecular pharmaceutics. doi:10.1021/acs.molpharmaceut.3c00700
2023
2022
AV-101, a Pro-Drug Antagonist at the NMDA Receptor Glycine Site, Reduces L-Dopa Induced Dyskinesias in MPTP Monkeys
Bourque, M., Gregoire, L., Patel, W., Dickens, D., Snodgrass, R., & Di Paolo, T. (2022). AV-101, a Pro-Drug Antagonist at the NMDA Receptor Glycine Site, Reduces L-Dopa Induced Dyskinesias in MPTP Monkeys. CELLS, 11(22). doi:10.3390/cells11223530
2021
Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex
Patel, W., Rimmer, L., Smith, M., Moss, L., Smith, M. A., Snodgrass, H. R., . . . Dickens, D. (2021). Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex. MOLECULAR PHARMACEUTICS, 18(1), 113-123. doi:10.1021/acs.molpharmaceut.0c00727
2019
Cigarette Smoke Exposure Induces Retrograde Trafficking of CFTR to the Endoplasmic Reticulum.
Marklew, A. J., Patel, W., Moore, P. J., Tan, C. D., Smith, A. J., Sassano, M. F., . . . Tarran, R. (2019). Cigarette Smoke Exposure Induces Retrograde Trafficking of CFTR to the Endoplasmic Reticulum.. Scientific reports, 9(1), 13655. doi:10.1038/s41598-019-49544-9
Increases in cytosolic Ca<sup>2+</sup> induce dynamin- and calcineurin-dependent internalisation of CFTR.
Patel, W., Moore, P. J., Sassano, M. F., Lopes-Pacheco, M., Aleksandrov, A. A., Amaral, M. D., . . . Gray, M. A. (2019). Increases in cytosolic Ca<sup>2+</sup> induce dynamin- and calcineurin-dependent internalisation of CFTR.. Cellular and molecular life sciences : CMLS, 76(5), 977-994. doi:10.1007/s00018-018-2989-3
2016
Increasing extracellular H2O2 produces a bi-phasic response in intracellular H2O2, with peroxiredoxin hyperoxidation only triggered once the cellular H2O2-buffering capacity is overwhelmed.
Tomalin, L. E., Day, A. M., Underwood, Z. E., Smith, G. R., Dalle Pezze, P., Rallis, C., . . . Veal, E. A. (2016). Increasing extracellular H2O2 produces a bi-phasic response in intracellular H2O2, with peroxiredoxin hyperoxidation only triggered once the cellular H2O2-buffering capacity is overwhelmed.. Free radical biology & medicine, 95, 333-348. doi:10.1016/j.freeradbiomed.2016.02.035
Metabolic regulation of Ca2+ homeostasis as a novel therapeutic strategy for pancreatic cancer
James, A., Patel, W., Butt, Z., Adiamah, M., Dakhel, R., Latif, A., . . . Bruce, J. (2016). Metabolic regulation of Ca2+ homeostasis as a novel therapeutic strategy for pancreatic cancer. Pancreatology, 16(3), S30. doi:10.1016/j.pan.2016.05.102
Hypercapnia modulates cAMP signalling and cystic fibrosis transmembrane conductance regulator-dependent anion and fluid secretion in airway epithelia.
Turner, M. J., Saint-Criq, V., Patel, W., Ibrahim, S. H., Verdon, B., Ward, C., . . . Gray, M. A. (2016). Hypercapnia modulates cAMP signalling and cystic fibrosis transmembrane conductance regulator-dependent anion and fluid secretion in airway epithelia.. The Journal of physiology, 594(6), 1643-1661. doi:10.1113/jp271309
2015
The Plasma Membrane Calcium Pump in Pancreatic Cancer Cells Exhibiting the Warburg Effect Relies on Glycolytic ATP.
James, A. D., Patel, W., Butt, Z., Adiamah, M., Dakhel, R., Latif, A., . . . Bruce, J. I. E. (2015). The Plasma Membrane Calcium Pump in Pancreatic Cancer Cells Exhibiting the Warburg Effect Relies on Glycolytic ATP.. The Journal of biological chemistry, 290(41), 24760-24771. doi:10.1074/jbc.m115.668707
2014
Insulin protects pancreatic acinar cells from palmitoleic acid-induced cellular injury.
Samad, A., James, A., Wong, J., Mankad, P., Whitehouse, J., Patel, W., . . . Bruce, J. I. E. (2014). Insulin protects pancreatic acinar cells from palmitoleic acid-induced cellular injury.. The Journal of biological chemistry, 289(34), 23582-23595. doi:10.1074/jbc.m114.589440
2013
Insulin protects pancreatic acinar cells against fatty acid/ethanol metabolites
Bruce, J. I. E., Samad, A., Patel, W., Alves-Simoes, M., Whitehouse, J., Mankad, P., & Siriwardena, A. (2013). Insulin protects pancreatic acinar cells against fatty acid/ethanol metabolites. Pancreatology, 13(2), e17. doi:10.1016/j.pan.2012.12.113