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Professor Warwick Dunn
BSc, PhD, FHEA, FRSC

Contact

Warwick.Dunn@liverpool.ac.uk

+44 (0)151 795 4558

Publications

Selected publications

  1. Investigation of the 12-Month Stability of Dried Blood and Urine Spots Applying Untargeted UHPLC-MS Metabolomic Assays (Journal article - 2019)
  2. Characterization of Monophasic Solvent-Based Tissue Extractions for the Detection of Polar Metabolites and Lipids Applying Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry Clinical Metabolic Phenotyping Assays (Journal article - 2021)
  3. AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome (Journal article - 2017)
  4. Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man (Journal article - 2016)
  5. Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy (Journal article - 2016)
  6. A new strategy for MS/MS data acquisition applying multiple data dependent experiments on Orbitrap mass spectrometers in non-targeted metabolomic applications (Journal article - 2015)
  7. Untargeted Metabolic Profiling Identifies Altered Serum Metabolites of Type 2 Diabetes Mellitus in a Prospective, Nested Case Control Study (Journal article - 2015)
  8. Molecular phenotyping of a UK population: defining the human serum metabolome (Journal article - 2015)
  9. Evidence That Multiple Defects in Lipid Regulation Occur before Hyperglycemia during the Prodrome of Type-2 Diabetes (Journal article - 2014)
  10. Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry (Journal article - 2011)
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2024

Metabolomics: Implication in cardiovascular research and diseases.

Ajoolabady, A., Pratico, D., Dunn, W. B., Lip, G. Y. H., & Ren, J. (2024). Metabolomics: Implication in cardiovascular research and diseases.. Obesity reviews : an official journal of the International Association for the Study of Obesity, 25(12), e13825. doi:10.1111/obr.13825

DOI
10.1111/obr.13825
Journal article

Development of microflow ultra high performance liquid chromatography-mass spectrometry metabolomic assays for analysis of mammalian biofluids.

Harwood-Stamper, A. J., Rowland, C. A., & Dunn, W. B. (2024). Development of microflow ultra high performance liquid chromatography-mass spectrometry metabolomic assays for analysis of mammalian biofluids.. Metabolomics : Official journal of the Metabolomic Society, 20(6), 120. doi:10.1007/s11306-024-02187-y

DOI
10.1007/s11306-024-02187-y
Journal article

Metabolomics 2023 workshop report: moving toward consensus on best QA/QC practices in LC-MS-based untargeted metabolomics.

Mosley, J. D., Dunn, W. B., Kuligowski, J., Lewis, M. R., Monge, M. E., Ulmer Holland, C., . . . Metabolomics Quality Assurance, Quality Control Consortium (mQACC). (2024). Metabolomics 2023 workshop report: moving toward consensus on best QA/QC practices in LC-MS-based untargeted metabolomics.. Metabolomics : Official journal of the Metabolomic Society, 20(4), 73. doi:10.1007/s11306-024-02135-w

DOI
10.1007/s11306-024-02135-w
Journal article

Bilateral remote ischemic conditioning in children: A two-center, double-blind, randomized controlled trial in young children undergoing cardiac surgery.

Drury, N. E., van Doorn, C., Woolley, R. L., Amos-Hirst, R. J., Bi, R., Spencer, C. M., . . . Bilateral Remote Ischemic Conditioning in Children Trial Investigators. (2024). Bilateral remote ischemic conditioning in children: A two-center, double-blind, randomized controlled trial in young children undergoing cardiac surgery.. JTCVS open, 18, 193-208. doi:10.1016/j.xjon.2024.02.018

DOI
10.1016/j.xjon.2024.02.018
Journal article

O241: A multi-omic systematic review of metabolites involved in predicting of the response to neoadjuvant therapy in locally advanced rectal cancer

Kler, A., Fok, M., Grundy, G., Sciacovelli, M., Dunn, W., & Vimalchandran, D. (2024). O241: A multi-omic systematic review of metabolites involved in predicting of the response to neoadjuvant therapy in locally advanced rectal cancer. British Journal of Surgery, 111(Supplement_2). doi:10.1093/bjs/znae046.020

DOI
10.1093/bjs/znae046.020
Journal article

2023

Metabolomics 2022 workshop report: state of QA/QC best practices in LC-MS-based untargeted metabolomics, informed through mQACC community engagement initiatives.

Dunn, W. B., Kuligowski, J., Lewis, M., Mosley, J. D., Schock, T., Ulmer Holland, C., . . . Metabolomics Quality Assurance and Quality Control Consortium (mQACC). (2023). Metabolomics 2022 workshop report: state of QA/QC best practices in LC-MS-based untargeted metabolomics, informed through mQACC community engagement initiatives.. Metabolomics : Official journal of the Metabolomic Society, 19(11), 93. doi:10.1007/s11306-023-02060-4

DOI
10.1007/s11306-023-02060-4
Journal article

Unlocking the secrets of the microbiome: exploring the dynamic microbial interplay with humans through metabolomics and their manipulation for synthetic biology applications.

Muhamadali, H., Winder, C. L., Dunn, W. B., & Goodacre, R. (2023). Unlocking the secrets of the microbiome: exploring the dynamic microbial interplay with humans through metabolomics and their manipulation for synthetic biology applications.. The Biochemical journal, 480(12), 891-908. doi:10.1042/bcj20210534

DOI
10.1042/bcj20210534
Journal article

Dysregulation of Amino Acid, Lipid, and Acylpyruvate Metabolism in Idiopathic Intracranial Hypertension: A Non-targeted Case Control and Longitudinal Metabolomic Study

Alimajstorovic, Z., Mollan, S. P., Grech, O., Mitchell, J. L., Yiangou, A., Thaller, M., . . . Sinclair, A. J. (2023). Dysregulation of Amino Acid, Lipid, and Acylpyruvate Metabolism in Idiopathic Intracranial Hypertension: A Non-targeted Case Control and Longitudinal Metabolomic Study. JOURNAL OF PROTEOME RESEARCH, 22(4), 1127-1137. doi:10.1021/acs.jproteome.2c00449

DOI
10.1021/acs.jproteome.2c00449
Journal article

A proposed framework to evaluate the quality and reliability of targeted metabolomics assays from the UK Consortium on Metabolic Phenotyping (MAP/UK).

Sarmad, S., Viant, M. R., Dunn, W. B., Goodacre, R., Wilson, I. D., Chappell, K. E., . . . UK Consortium on Metabolic Phenotyping (MAP/UK). (2023). A proposed framework to evaluate the quality and reliability of targeted metabolomics assays from the UK Consortium on Metabolic Phenotyping (MAP/UK).. Nature protocols. doi:10.1038/s41596-022-00801-8

DOI
10.1038/s41596-022-00801-8
Journal article

2022

Providing metabolomics education and training: pedagogy and considerations

Winder, C. L., Witting, M., Tugizimana, F., Dunn, W. B., & Reinke, S. N. (2022). Providing metabolomics education and training: pedagogy and considerations. METABOLOMICS, 18(12). doi:10.1007/s11306-022-01957-w

DOI
10.1007/s11306-022-01957-w
Journal article

Acute effects of prior dietary fat ingestion on postprandial metabolic responses to protein and carbohydrate co-ingestion in overweight and obese men: A randomised crossover trial

Wilhelmsen, A., Davies, A., Mallinson, J., Pabla, P., Jones, R., Palmer, E. A., . . . Tsintzas, K. (2022). Acute effects of prior dietary fat ingestion on postprandial metabolic responses to protein and carbohydrate co-ingestion in overweight and obese men: A randomised crossover trial. CLINICAL NUTRITION, 41(8), 1623-1635. doi:10.1016/j.clnu.2022.06.022

DOI
10.1016/j.clnu.2022.06.022
Journal article

Suitability of Dried Blood Spots for Accelerating Veterinary Biobank Collections and Identifying Metabolomics Biomarkers With Minimal Resources

Allaway, D., Alexander, J. E., Carvell-Miller, L. J., Reynolds, R. M., Winder, C. L., Weber, R. J. M., . . . Dunn, W. B. (2022). Suitability of Dried Blood Spots for Accelerating Veterinary Biobank Collections and Identifying Metabolomics Biomarkers With Minimal Resources. FRONTIERS IN VETERINARY SCIENCE, 9. doi:10.3389/fvets.2022.887163

DOI
10.3389/fvets.2022.887163
Journal article

Reference materials for MS-based untargeted metabolomics and lipidomics: a review by the metabolomics quality assurance and quality control consortium (mQACC).

Lippa, K. A., Aristizabal-Henao, J. J., Beger, R. D., Bowden, J. A., Broeckling, C., Beecher, C., . . . Ubhi, B. K. (2022). Reference materials for MS-based untargeted metabolomics and lipidomics: a review by the metabolomics quality assurance and quality control consortium (mQACC).. Metabolomics : Official journal of the Metabolomic Society, 18(4), 24. doi:10.1007/s11306-021-01848-6

DOI
10.1007/s11306-021-01848-6
Journal article

2021

Chorioamnionitis alters lung surfactant lipidome in newborns with respiratory distress syndrome

Giambelluca, S., Verlato, G., Simonato, M., Vedovelli, L., Bonadies, L., Najdekr, L., . . . Cogo, P. (2021). Chorioamnionitis alters lung surfactant lipidome in newborns with respiratory distress syndrome. PEDIATRIC RESEARCH, 90(5), 1039-1043. doi:10.1038/s41390-021-01371-3

DOI
10.1038/s41390-021-01371-3
Journal article

An improved strategy for analysis of lipid molecules utilising a reversed phase C<sub>30</sub> UHPLC column and scheduled MS/MS acquisition

Jankevics, A., Jenkins, A., Dunn, W. B., & Najdekr, L. (2021). An improved strategy for analysis of lipid molecules utilising a reversed phase C<sub>30</sub> UHPLC column and scheduled MS/MS acquisition. TALANTA, 229. doi:10.1016/j.talanta.2021.122262

DOI
10.1016/j.talanta.2021.122262
Journal article

Maternal intermittent fasting during pregnancy induces fetal growth restriction and down-regulated placental system A amino acid transport in the rat.

Alkhalefah, A., Dunn, W. B., Allwood, J. W., Parry, K. L., Houghton, F. D., Ashton, N., & Glazier, J. D. (2021). Maternal intermittent fasting during pregnancy induces fetal growth restriction and down-regulated placental system A amino acid transport in the rat.. Clinical science (London, England : 1979), 135(11), 1445-1466. doi:10.1042/cs20210137

DOI
10.1042/cs20210137
Journal article

Improvement in the Prediction of Neonatal Hypoxic-Ischemic Encephalopathy with the Integration of Umbilical Cord Metabolites and Current Clinical Makers

O'Boyle, D. S., Dunn, W. B., O'Neill, D., Kirwan, J. A., Broadhurst, D. I., Hallberg, B., . . . Murray, D. M. (2021). Improvement in the Prediction of Neonatal Hypoxic-Ischemic Encephalopathy with the Integration of Umbilical Cord Metabolites and Current Clinical Makers. JOURNAL OF PEDIATRICS, 229, 175-+. doi:10.1016/j.jpeds.2020.09.065

DOI
10.1016/j.jpeds.2020.09.065
Journal article

Metabolic characterisation of disturbances in the <i>APOC3</i>/triglyceride-rich lipoprotein pathway through sample-based recall by genotype (vol 16, 69, 2020)

Corbin, L. J., Hughes, D. A., Chetwynd, A. J., Taylor, A. E., Southam, A. D., Jankevics, A., . . . Timpson, N. J. (2021). Metabolic characterisation of disturbances in the <i>APOC3</i>/triglyceride-rich lipoprotein pathway through sample-based recall by genotype (vol 16, 69, 2020). METABOLOMICS, 17(2). doi:10.1007/s11306-020-01765-0

DOI
10.1007/s11306-020-01765-0
Journal article

Characterization of Monophasic Solvent-Based Tissue Extractions for the Detection of Polar Metabolites and Lipids Applying Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry Clinical Metabolic Phenotyping Assays

Southam, A. D., Pursell, H., Frigerio, G., Jankevics, A., Weber, R. J. M., & Dunn, W. B. (2021). Characterization of Monophasic Solvent-Based Tissue Extractions for the Detection of Polar Metabolites and Lipids Applying Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry Clinical Metabolic Phenotyping Assays. JOURNAL OF PROTEOME RESEARCH, 20(1), 831-840. doi:10.1021/acs.jproteome.0c00660

DOI
10.1021/acs.jproteome.0c00660
Journal article

2020

Assessment of human plasma and urine sample preparation for reproducible and high-throughput UHPLC-MS clinical metabolic phenotyping

Southam, A. D., Haglington, L. D., Najdekr, L., Jankevics, A., Weber, R. J. M., & Dunn, W. B. (2020). Assessment of human plasma and urine sample preparation for reproducible and high-throughput UHPLC-MS clinical metabolic phenotyping. ANALYST, 145(20), 6511-6523. doi:10.1039/d0an01319f

DOI
10.1039/d0an01319f
Journal article

Dissemination and analysis of the quality assurance (QA) and quality control (QC) practices of LC-MS based untargeted metabolomics practitioners

Evans, A. M., O'Donovan, C., Playdon, M., Beecher, C., Beger, R. D., Bowden, J. A., . . . Vuckovic, D. (2020). Dissemination and analysis of the quality assurance (QA) and quality control (QC) practices of LC-MS based untargeted metabolomics practitioners. METABOLOMICS, 16(10). doi:10.1007/s11306-020-01728-5

DOI
10.1007/s11306-020-01728-5
Journal article

Bilateral Remote Ischaemic Conditioning in Children (BRICC) trial: protocol for a two-centre, double-blind, randomised controlled trial in young children undergoing cardiac surgery

Drury, N. E., Bi, R., Woolley, R. L., Stickley, J., Morris, K. P., Montgomerie, J., . . . Jones, T. J. (2020). Bilateral Remote Ischaemic Conditioning in Children (BRICC) trial: protocol for a two-centre, double-blind, randomised controlled trial in young children undergoing cardiac surgery. BMJ OPEN, 10(10). doi:10.1136/bmjopen-2020-042176

DOI
10.1136/bmjopen-2020-042176
Journal article

Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity

Fultang, L., Booth, S., Yogev, O., da Costa, B. M., Tubb, V., Panetti, S., . . . De Santo, C. (2020). Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity. BLOOD, 136(10), 1155-1160. doi:10.1182/blood.2019004500

DOI
10.1182/blood.2019004500
Journal article

Beta-aminoisobutyric acid is released by contracting human skeletal muscle and lowers insulin release from INS-1 832/3 cells by mediating mitochondrial energy metabolism.

Barlow, J. P., Karstoft, K., Vigelsø, A., Gram, M., Helge, J. W., Dela, F., . . . Solomon, T. P. J. (2020). Beta-aminoisobutyric acid is released by contracting human skeletal muscle and lowers insulin release from INS-1 832/3 cells by mediating mitochondrial energy metabolism.. Metabolism open, 7, 100053. doi:10.1016/j.metop.2020.100053

DOI
10.1016/j.metop.2020.100053
Journal article

Urinary biomonitoring of subjects with different smoking habits. Part II: an untargeted metabolomic approach and the comparison with the targeted measurement of mercapturic acids

Frigerio, G., Mercadante, R., Campo, L., Polledri, E., Boniardi, L., Olgiati, L., . . . Fustinoni, S. (2020). Urinary biomonitoring of subjects with different smoking habits. Part II: an untargeted metabolomic approach and the comparison with the targeted measurement of mercapturic acids. TOXICOLOGY LETTERS, 329, 56-66. doi:10.1016/j.toxlet.2020.03.020

DOI
10.1016/j.toxlet.2020.03.020
Journal article

Intestinal permeability in participants with thermal injury: A case series from a prospective, longitudinal study (HESTIA)

Tipple, C., Moiemen, N. S., Ioannou, C., Paglione, M., Goodson, S., McGee, K., . . . Berger, S. (2020). Intestinal permeability in participants with thermal injury: A case series from a prospective, longitudinal study (HESTIA). Burns Open, 4(3), 94-102. doi:10.1016/j.burnso.2020.05.005

DOI
10.1016/j.burnso.2020.05.005
Journal article

DGAT1 is a lipid metabolism oncoprotein that enables cancer cells to accumulate fatty acid while avoiding lipotoxicity

DOI
10.1101/2020.06.23.166603
Preprint

Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing

Wilkinson, D. J., Rodriguez-Blanco, G., Dunn, W. B., Phillips, B. E., Williams, J. P., Greenhaff, P. L., . . . Atherton, P. J. (2020). Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing. AGING-US, 12(13), 12517-12533. doi:10.18632/aging.103513

DOI
10.18632/aging.103513
Journal article

Metabolic characterisation of disturbances in the<i>APOC3</i>/triglyceride-rich lipoprotein pathway through sample-based recall by genotype

Corbin, L. J., Hughes, D. A., Chetwynd, A. J., Taylor, A. E., Southam, A. D., Jankevics, A., . . . Timpson, N. J. (2020). Metabolic characterisation of disturbances in the<i>APOC3</i>/triglyceride-rich lipoprotein pathway through sample-based recall by genotype. METABOLOMICS, 16(6). doi:10.1007/s11306-020-01689-9

DOI
10.1007/s11306-020-01689-9
Journal article

Multi-Omics Analysis of Diabetic Heart Disease in the <i>db/db</i> Model Reveals Potential Targets for Treatment by a Longevity-Associated Gene

Faulkner, A., Dang, Z., Avolio, E., Thomas, A. C., Batstone, T., Lloyd, G. R., . . . Madeddu, P. (2020). Multi-Omics Analysis of Diabetic Heart Disease in the <i>db/db</i> Model Reveals Potential Targets for Treatment by a Longevity-Associated Gene. CELLS, 9(5). doi:10.3390/cells9051283

DOI
10.3390/cells9051283
Journal article

SERUM METABOLOMIC PROFILES IDENTIFY ALTERATIONS IN LIPID METABOLISM IN PREMENARCHAL GIRLS AT INCREASED RISK FOR PCOS

Torchen, L., Dunn, W., Arlt, W., & Dunaif, A. (2020). SERUM METABOLOMIC PROFILES IDENTIFY ALTERATIONS IN LIPID METABOLISM IN PREMENARCHAL GIRLS AT INCREASED RISK FOR PCOS. In JOURNAL OF INVESTIGATIVE MEDICINE Vol. 68 (pp. 1073-1074). doi:10.1136/jim-2020-MW.67

DOI
10.1136/jim-2020-MW.67
Conference Paper

The metabolomic profile of endometrial receptivity in recurrent miscarriage

Craciunas, L., Chu, J., Pickering, O., Mohiyiddeen, L., Dunn, W., & Coomarasamy, A. (2020). The metabolomic profile of endometrial receptivity in recurrent miscarriage. In HUMAN REPRODUCTION Vol. 35 (pp. 90-91). Retrieved from https://www.webofscience.com/

Conference Paper

2019

Comparison of modified Matyash method to conventional solvent systems for polar metabolite and lipid extractions (vol 1037, pg 301, 2018)

Sostare, E., Di Guida, R., Kirwan, J., Chalal, K., Palmer, E., Dunn, W. B., & Viant, M. R. (2019). Comparison of modified Matyash method to conventional solvent systems for polar metabolite and lipid extractions (vol 1037, pg 301, 2018). ANALYTICA CHIMICA ACTA, 1091, 169. doi:10.1016/j.aca.2019.09.069

DOI
10.1016/j.aca.2019.09.069
Journal article

International Ring Trial of a High Resolution Targeted Metabolomics and Lipidomics Platform for Serum and Plasma Analysis

Thompson, J. W., Adams, K. J., Adamski, J., Asad, Y., Borts, D., Bowden, J. A., . . . Moseley, M. A. (2019). International Ring Trial of a High Resolution Targeted Metabolomics and Lipidomics Platform for Serum and Plasma Analysis. ANALYTICAL CHEMISTRY, 91(22), 14407-14416. doi:10.1021/acs.analchem.9b02908

DOI
10.1021/acs.analchem.9b02908
Journal article

Investigation of the 12-Month Stability of Dried Blood and Urine Spots Applying Untargeted UHPLC-MS Metabolomic Assays

Palmer, E. A., Cooper, H. J., & Dunn, W. B. (2019). Investigation of the 12-Month Stability of Dried Blood and Urine Spots Applying Untargeted UHPLC-MS Metabolomic Assays. ANALYTICAL CHEMISTRY, 91(22), 14306-14313. doi:10.1021/acs.analchem.9b02577

DOI
10.1021/acs.analchem.9b02577
Journal article

Intracrine activation of 11-oxygenated androgens by AKR1C3 modulates lipid metabolism in human female adipose tissue

Schiffer, L., Sinclair, A. J., O'Reilly, M. W., Westgate, C., Mashood, A., Palmer, E., . . . Storbeck, K. -H. (n.d.). Intracrine activation of 11-oxygenated androgens by AKR1C3 modulates lipid metabolism in human female adipose tissue. Endocrine Abstracts. doi:10.1530/endoabs.65.oc1.1

DOI
10.1530/endoabs.65.oc1.1
Journal article

Systemic and femoral adipose tissue-specific nontargeted plasma metabolome during acute hypercortisolaemia

Prete, A., Dunn, W. B., & Manolopoulos, K. (n.d.). Systemic and femoral adipose tissue-specific nontargeted plasma metabolome during acute hypercortisolaemia. Endocrine Abstracts. doi:10.1530/endoabs.65.p199

DOI
10.1530/endoabs.65.p199
Journal article

From mass to metabolite in human untargeted metabolomics: Recent advances in annotation of metabolites applying liquid chromatography-mass spectrometry data

Nash, W. J., & Dunn, W. B. (2019). From mass to metabolite in human untargeted metabolomics: Recent advances in annotation of metabolites applying liquid chromatography-mass spectrometry data. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 120. doi:10.1016/j.trac.2018.11.022

DOI
10.1016/j.trac.2018.11.022
Journal article

Systematic Review: Clinical Metabolomics to Forecast Outcomes in Liver Transplantation Surgery

Attard, J. A., Dunn, W. B., Mergental, H., Mirza, D. F., Afford, S. C., & Perera, T. P. R. (2019). Systematic Review: Clinical Metabolomics to Forecast Outcomes in Liver Transplantation Surgery. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 23(10), 463-476. doi:10.1089/omi.2019.0086

DOI
10.1089/omi.2019.0086
Journal article

Bidirectional Cross-Talk between Biliary Epithelium and Th17 Cells Promotes Local Th17 Expansion and Bile Duct Proliferation in Biliary Liver Diseases

Jeffery, H. C., Hunter, S., Humphreys, E. H., Bhogal, R., Wawman, R. E., Birtwistle, J., . . . Oo, Y. H. (2019). Bidirectional Cross-Talk between Biliary Epithelium and Th17 Cells Promotes Local Th17 Expansion and Bile Duct Proliferation in Biliary Liver Diseases. JOURNAL OF IMMUNOLOGY, 203(5), 1151-1159. doi:10.4049/jimmunol.1800455

DOI
10.4049/jimmunol.1800455
Journal article

Multiple metabolic pathways are predictive of ricin intoxication in a rat model

D'Elia, R. V., Goodchild, S. A., Winder, C. L., Southam, A. D., Weber, R. J. M., Stahl, F. M., . . . Dunn, W. B. (2019). Multiple metabolic pathways are predictive of ricin intoxication in a rat model. METABOLOMICS, 15(7). doi:10.1007/s11306-019-1547-9

DOI
10.1007/s11306-019-1547-9
Journal article

Effects of Chronic Hypervitaminosis a on Global Plasma Metabolome Changes and Liver Gene Expression (OR05-06-19)

Lietz, G., Oxley, A., Finney, K., Clark, A., Giles, T., Foster, N., . . . Dunn, W. (2019). Effects of Chronic Hypervitaminosis a on Global Plasma Metabolome Changes and Liver Gene Expression (OR05-06-19). Current Developments in Nutrition, 3. doi:10.1093/cdn/nzz029.or05-06-19

DOI
10.1093/cdn/nzz029.or05-06-19
Journal article

The Effect of Chronic High Dose Vitamin a Supplementation on Lipid Metabolism in Adipose Tissue (P02-013-19)

Finney, K., Oxley, A., Winder, C., Southam, A., Jankevics, A., Lloyd, G., . . . Lietz, G. (2019). The Effect of Chronic High Dose Vitamin a Supplementation on Lipid Metabolism in Adipose Tissue (P02-013-19). Current Developments in Nutrition, 3. doi:10.1093/cdn/nzz029.p02-013-19

DOI
10.1093/cdn/nzz029.p02-013-19
Journal article

Enhanced Fatty Acid Scavenging and Glycerophospholipid Metabolism Accompany Melanocyte Neoplasia Progression in Zebrafish

Henderson, F., Johnston, H. R., Badrock, A. P., Jones, E. A., Forster, D., Nagaraju, R. T., . . . Hurlstone, A. (2019). Enhanced Fatty Acid Scavenging and Glycerophospholipid Metabolism Accompany Melanocyte Neoplasia Progression in Zebrafish. CANCER RESEARCH, 79(9), 2136-2151. doi:10.1158/0008-5472.CAN-18-2409

DOI
10.1158/0008-5472.CAN-18-2409
Journal article

Gestational route to healthy birth (GaRBH): protocol for an Indian prospective cohort study

Gupta, V., Saxena, R., Walia, G. K., Agarwal, T., Vats, H., Dunn, W., . . . Sachdeva, M. P. (2019). Gestational route to healthy birth (GaRBH): protocol for an Indian prospective cohort study. BMJ OPEN, 9(4). doi:10.1136/bmjopen-2018-025395

DOI
10.1136/bmjopen-2018-025395
Journal article

MON-203 Local Activation of 11-Oxygenated Androgens by AKR1C3 Is the Predominant Source of Androgens in Human Female Adipose Tissue

Schiffer, L., Sinclair, A., Ludwig, C., O'Reilly, M., Westgate, C., Singhal, R., . . . Storbeck, K. -H. (2019). MON-203 Local Activation of 11-Oxygenated Androgens by AKR1C3 Is the Predominant Source of Androgens in Human Female Adipose Tissue. Journal of the Endocrine Society, 3(Supplement_1). doi:10.1210/js.2019-mon-203

DOI
10.1210/js.2019-mon-203
Journal article

Towards quality assurance and quality control in untargeted metabolomics studies

Beger, R. D., Dunn, W. B., Bandukwala, A., Bethan, B., Broadhurst, D., Clish, C. B., . . . Zanetti, K. A. (2019). Towards quality assurance and quality control in untargeted metabolomics studies. METABOLOMICS, 15(1). doi:10.1007/s11306-018-1460-7

DOI
10.1007/s11306-018-1460-7
Journal article

Chapter 3 The Role of Ultra Performance Liquid Chromatography-Mass Spectrometry in Metabolic Phenotyping

Dunn, W. B., & Lewis, M. R. (2019). Chapter 3 The Role of Ultra Performance Liquid Chromatography-Mass Spectrometry in Metabolic Phenotyping. In The Handbook of Metabolic Phenotyping (pp. 97-136). Elsevier. doi:10.1016/b978-0-12-812293-8.00003-7

DOI
10.1016/b978-0-12-812293-8.00003-7
Chapter

Collection of Untargeted Metabolomic Data for Mammalian Urine Applying HILIC and Reversed Phase Ultra Performance Liquid Chromatography Methods Coupled to a Q Exactive Mass Spectrometer.

Najdekr, L., Blanco, G. R., & Dunn, W. B. (2019). Collection of Untargeted Metabolomic Data for Mammalian Urine Applying HILIC and Reversed Phase Ultra Performance Liquid Chromatography Methods Coupled to a Q Exactive Mass Spectrometer.. In Unknown Book (Vol. 1996, pp. 1-15). doi:10.1007/978-1-4939-9488-5_1

DOI
10.1007/978-1-4939-9488-5_1
Chapter

Untargeted metabolomic analysis and pathway discovery in perinatal asphyxia and hypoxic-ischaemic encephalopathy

Denihan, N. M., Kirwan, J. A., Walsh, B. H., Dunn, W. B., Broadhurst, D. I., Boylan, G. B., & Murray, D. M. (2019). Untargeted metabolomic analysis and pathway discovery in perinatal asphyxia and hypoxic-ischaemic encephalopathy. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 39(1), 147-162. doi:10.1177/0271678X17726502

DOI
10.1177/0271678X17726502
Journal article

Viability Testing and Transplantation of Marginal Donor Livers (VITTAL) Trial: Metabolomics of Ex Vivo Normothermically Machine Perfused Livers Discloses Molecular Signatures Predictive of Graft Viability and Post Transplant Outcomes.

Attard, J., Dunn, W., Wallace, L., Laing, R., Boteon, Y., Mergental, H., . . . Afford, S. (2019). Viability Testing and Transplantation of Marginal Donor Livers (VITTAL) Trial: Metabolomics of Ex Vivo Normothermically Machine Perfused Livers Discloses Molecular Signatures Predictive of Graft Viability and Post Transplant Outcomes.. In AMERICAN JOURNAL OF TRANSPLANTATION Vol. 19 (pp. 341). Retrieved from https://www.webofscience.com/

Conference Paper

2018

Comparison of modified Matyash method to conventional solvent systems for polar metabolite and lipid extractions.

Sostare, J., Di Guida, R., Kirwan, J., Chalal, K., Palmer, E., Dunn, W. B., & Viant, M. R. (2018). Comparison of modified Matyash method to conventional solvent systems for polar metabolite and lipid extractions.. Analytica chimica acta, 1037, 301-315. doi:10.1016/j.aca.2018.03.019

DOI
10.1016/j.aca.2018.03.019
Journal article

Nicotinamide Nucleotide Transhydrogenase as a Novel Treatment Target in Adrenocortical Carcinoma.

Chortis, V., Taylor, A. E., Doig, C. L., Walsh, M. D., Meimaridou, E., Jenkinson, C., . . . Foster, P. A. (2018). Nicotinamide Nucleotide Transhydrogenase as a Novel Treatment Target in Adrenocortical Carcinoma.. Endocrinology, 159(8), 2836-2849. doi:10.1210/en.2018-00014

DOI
10.1210/en.2018-00014
Journal article

Preanalytical Processing and Biobanking Procedures of Biological Samples for Metabolomics Research: A White Paper, Community Perspective (for "Precision Medicine and Pharmacometabolomics Task Group"-The Metabolomics Society Initiative).

Kirwan, J. A., Brennan, L., Broadhurst, D., Fiehn, O., Cascante, M., Dunn, W. B., . . . Velagapudi, V. (2018). Preanalytical Processing and Biobanking Procedures of Biological Samples for Metabolomics Research: A White Paper, Community Perspective (for "Precision Medicine and Pharmacometabolomics Task Group"-The Metabolomics Society Initiative).. Clinical chemistry, 64(8), 1158-1182. doi:10.1373/clinchem.2018.287045

DOI
10.1373/clinchem.2018.287045
Journal article

Abstract 4109: Multi-modality imaging to interrogate lipidome changes during melanoma progression in zebrafish

Henderson, F., Johnston, H., Jones, E., Foster, D., Nagaraju, R. T., Green, M., . . . McMahon, A. (2018). Abstract 4109: Multi-modality imaging to interrogate lipidome changes during melanoma progression in zebrafish. Cancer Research, 78(13_Supplement), 4109. doi:10.1158/1538-7445.am2018-4109

DOI
10.1158/1538-7445.am2018-4109
Journal article

TBIO-19. MASS SPECTROMETRY OF COMMON CEREBELLAR TUMOURS IDENTIFIES DIFFERENCES IN METABOLISM

Bennett, C., Kohe, S., Gill, S., Davies, N., Storer, L., Ritzmann, T., . . . Peet, A. (2018). TBIO-19. MASS SPECTROMETRY OF COMMON CEREBELLAR TUMOURS IDENTIFIES DIFFERENCES IN METABOLISM. Neuro-Oncology, 20(suppl_2), i184. doi:10.1093/neuonc/noy059.707

DOI
10.1093/neuonc/noy059.707
Journal article

Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies

Broadhurst, D., Goodacre, R., Reinke, S. N., Kuligowski, J., Wilson, I. D., Lewis, M. R., & Dunn, W. B. (2018). Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies. METABOLOMICS, 14(6). doi:10.1007/s11306-018-1367-3

DOI
10.1007/s11306-018-1367-3
Journal article

Nicotinamide Nucleotide Transhydrogenase as a novel treatment target in adrenocortical carcinoma

Chortis, V., Taylor, A., Doig, C., Walsh, M., Meimaridou, E., Jenkinson, C., . . . Foster, P. (n.d.). Nicotinamide Nucleotide Transhydrogenase as a novel treatment target in adrenocortical carcinoma. Endocrine Abstracts. doi:10.1530/endoabs.56.gp23

DOI
10.1530/endoabs.56.gp23
Journal article

Identification of the functional pathways altered by placental cell exposure to high glucose: lessons from the transcript and metabolite interactome.

Hulme, C. H., Stevens, A., Dunn, W., Heazell, A. E. P., Hollywood, K., Begley, P., . . . Myers, J. E. (2018). Identification of the functional pathways altered by placental cell exposure to high glucose: lessons from the transcript and metabolite interactome.. Scientific reports, 8(1), 5270. doi:10.1038/s41598-018-22535-y

DOI
10.1038/s41598-018-22535-y
Journal article

The Role of Ultra Performance Liquid Chromatography-Mass Spectrometry in Metabolic Phenotyping

Dunn, W. B., & Lewis, M. R. (2019). The Role of Ultra Performance Liquid Chromatography-Mass Spectrometry in Metabolic Phenotyping. In The Handbook of Metabolic Phenotyping (pp. 97-136). Elsevier. doi:10.1016/b978-0-12-812293-8.00003-7

DOI
10.1016/b978-0-12-812293-8.00003-7
Chapter

2017

Antioxidant pathway targeting as a therapeutic approach in adrenocortical carcinoma

Chortis, V., Taylor, A. E., Doig, C. L., Meimaridou, E., Walsh, M., Jenkinson, C., . . . Foster, P. A. (n.d.). Antioxidant pathway targeting as a therapeutic approach in adrenocortical carcinoma. Endocrine Abstracts. doi:10.1530/endoabs.50.oc1.3

DOI
10.1530/endoabs.50.oc1.3
Journal article

Adipose tissue and metabolic and inflammatory responses to stroke are altered in obese mice.

Haley, M. J., Mullard, G., Hollywood, K. A., Cooper, G. J., Dunn, W. B., & Lawrence, C. B. (2017). Adipose tissue and metabolic and inflammatory responses to stroke are altered in obese mice.. Disease models & mechanisms, 10(10), 1229-1243. doi:10.1242/dmm.030411

DOI
10.1242/dmm.030411
Journal article

AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome

O'Reilly, M. W., Kempegowda, P., Walsh, M., Taylor, A. E., Manolopoulos, K. N., Allwood, J. W., . . . Arlt, W. (2017). AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 102(9), 3327-3339. doi:10.1210/jc.2017-00947

DOI
10.1210/jc.2017-00947
Journal article

AKR1C3-mediated adipose androgen generation drives lipotoxicity in polycystic ovary syndrome

O'Reilly, M., Kempegowda, P., Walsh, M., Taylor, A., Manolopoulos, K., Allwood, W., . . . Arlt, W. (n.d.). AKR1C3-mediated adipose androgen generation drives lipotoxicity in polycystic ovary syndrome. Endocrine Abstracts. doi:10.1530/endoabs.49.oc3.3

DOI
10.1530/endoabs.49.oc3.3
Journal article

msPurity: Automated Evaluation of Precursor Ion Purity for Mass Spectrometry-Based Fragmentation in Metabolomics

Lawson, T. N., Weber, R. J. M., Jones, M. R., Chetwynd, A. J., Rodriguez-Blanco, G., Di Guida, R., . . . Dunn, W. B. (2017). msPurity: Automated Evaluation of Precursor Ion Purity for Mass Spectrometry-Based Fragmentation in Metabolomics. ANALYTICAL CHEMISTRY, 89(4), 2432-2439. doi:10.1021/acs.analchem.6b04358

DOI
10.1021/acs.analchem.6b04358
Journal article

Computational tools and workflows in metabolomics: An international survey highlights the opportunity for harmonisation through Galaxy

Weber, R. J. M., Lawson, T. N., Salek, R. M., Ebbels, T. M. D., Glen, R. C., Goodacre, R., . . . Viant, M. R. (2017). Computational tools and workflows in metabolomics: An international survey highlights the opportunity for harmonisation through Galaxy. METABOLOMICS, 13(2). doi:10.1007/s11306-016-1147-x

DOI
10.1007/s11306-016-1147-x
Journal article

How close are we to complete annotation of metabolomes?

Viant, M. R., Kurland, I. J., Jones, M. R., & Dunn, W. B. (2017). How close are we to complete annotation of metabolomes?. CURRENT OPINION IN CHEMICAL BIOLOGY, 36, 64-69. doi:10.1016/j.cbpa.2017.01.001

DOI
10.1016/j.cbpa.2017.01.001
Journal article

MALDI-MS of drugs: Profiling, imaging, and steps towards quantitative analysis

Turker, S. D., Dunn, W. B., & Wilkie, J. (2017). MALDI-MS of drugs: Profiling, imaging, and steps towards quantitative analysis. Applied Spectroscopy Reviews, 52(1), 73-99. doi:10.1080/05704928.2016.1207659

DOI
10.1080/05704928.2016.1207659
Journal article

Collection and Preparation of Clinical Samples for Metabolomics.

Chetwynd, A. J., Dunn, W. B., & Rodriguez-Blanco, G. (2017). Collection and Preparation of Clinical Samples for Metabolomics.. In Unknown Book (Vol. 965, pp. 19-44). doi:10.1007/978-3-319-47656-8_2

DOI
10.1007/978-3-319-47656-8_2
Chapter

The future of metabolomics in ELIXIR

van Rijswijk, M., Beirnaert, C., Caron, C., Cascante, M., Dominguez, V., Dunn, W. B., . . . Steinbeck, C. (n.d.). The future of metabolomics in ELIXIR. F1000Research, 6, 1649. doi:10.12688/f1000research.12342.1

DOI
10.12688/f1000research.12342.1
Journal article

2016

Metabolomics enables precision medicine: "A White Paper, Community Perspective"

Beger, R. D., Dunn, W., Schmidt, M. A., Gross, S. S., Kirwan, J. A., Cascante, M., . . . Kaddurah-Daouk, R. (2016). Metabolomics enables precision medicine: "A White Paper, Community Perspective". METABOLOMICS, 12(9). doi:10.1007/s11306-016-1094-6

DOI
10.1007/s11306-016-1094-6
Journal article

OC09.03: Metabolomic changes in amniotic fluid from Twin–twin transfusion syndrome recipient twins in relation to treatment and fetal cardiovascular risk

Mackie, F. L., Dunn, W. B., Allwood, J. W., Van Mieghem, T., Morris, R. K., Fox, C. E., & Kilby, M. D. (2016). OC09.03: Metabolomic changes in amniotic fluid from Twin–twin transfusion syndrome recipient twins in relation to treatment and fetal cardiovascular risk. Ultrasound in Obstetrics &amp; Gynecology, 48(S1), 16-17. doi:10.1002/uog.16069

DOI
10.1002/uog.16069
Journal article

Carbohydrate and fatty acid perturbations in the amniotic fluid of the recipient twin of pregnancies complicated by twin-twin transfusion syndrome in relation to treatment and fetal cardiovascular risk

Dunn, W. B., Allwood, J. W., Van Mieghem, T., Morris, R. K., Mackie, F. L., Fox, C. E., & Kilby, M. D. (2016). Carbohydrate and fatty acid perturbations in the amniotic fluid of the recipient twin of pregnancies complicated by twin-twin transfusion syndrome in relation to treatment and fetal cardiovascular risk. PLACENTA, 44, 6-12. doi:10.1016/j.placenta.2016.05.012

DOI
10.1016/j.placenta.2016.05.012
Journal article

Characterisation of the metabolome of ocular tissues and post-mortem changes in the rat retina

Tan, S. Z., Mullard, G., Hollywood, K. A., Dunn, W. B., & Bishop, P. N. (2016). Characterisation of the metabolome of ocular tissues and post-mortem changes in the rat retina. EXPERIMENTAL EYE RESEARCH, 149, 8-15. doi:10.1016/j.exer.2016.05.019

DOI
10.1016/j.exer.2016.05.019
Journal article

Metabolites involved in glycolysis and amino acid metabolism are altered in short children born small for gestational age

Murray, P. G., Butcher, I., Dunn, W. B., Stevens, A., Perchard, R., Hanson, D., . . . Clayton, P. E. (2016). Metabolites involved in glycolysis and amino acid metabolism are altered in short children born small for gestational age. PEDIATRIC RESEARCH, 80(2), 299-305. doi:10.1038/pr.2016.72

DOI
10.1038/pr.2016.72
Journal article

Non-targeted UHPLC-MS metabolomic data processing methods: a comparative investigation of normalisation, missing value imputation, transformation and scaling

Di Guida, R., Engel, J., Allwood, J. W., Weber, R. J. M., Jones, M. R., Sommer, U., . . . Dunn, W. B. (2016). Non-targeted UHPLC-MS metabolomic data processing methods: a comparative investigation of normalisation, missing value imputation, transformation and scaling. METABOLOMICS, 12(5). doi:10.1007/s11306-016-1030-9

DOI
10.1007/s11306-016-1030-9
Journal article

A1.18 Mesenchymal stem cells lose their immuno-protective effects upon changes in their local microenvironment

Munir, H., Benjamin, A., Allwood, J. W., Dunn, W. B., He, S., Nash, G. B., & McGettrick, H. M. (2016). A1.18 Mesenchymal stem cells lose their immuno-protective effects upon changes in their local microenvironment. Annals of the Rheumatic Diseases, 75(Suppl 1), A8.1-A8. doi:10.1136/annrheumdis-2016-209124.18

DOI
10.1136/annrheumdis-2016-209124.18
Journal article

Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man

Hazlehurst, J. M., Oprescu, A. I., Nikolaou, N., Di Guida, R., Grinbergs, A. E. K., Davies, N. P., . . . Tomlinson, J. W. (2016). Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 101(1), 102-112. doi:10.1210/jc.2015-2928

DOI
10.1210/jc.2015-2928
Journal article

Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy

Freeman, O. J., Unwin, R. D., Dowsey, A. W., Begley, P., Ali, S., Hollywood, K. A., . . . Gardiner, N. J. (2016). Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy. DIABETES, 65(1), 228-238. doi:10.2337/db15-0835

DOI
10.2337/db15-0835
Journal article

Metabolomics reveals the physiological response of <i>Pseudomonas</i> <i>putida</i> KT2440 (UWC1) after pharmaceutical exposure

Currie, F., Broadhurst, D. I., Dunn, W. B., Sellick, C. A., & Goodacre, R. (2016). Metabolomics reveals the physiological response of <i>Pseudomonas</i> <i>putida</i> KT2440 (UWC1) after pharmaceutical exposure. MOLECULAR BIOSYSTEMS, 12(4), 1367-1377. doi:10.1039/c5mb00889a

DOI
10.1039/c5mb00889a
Journal article

2015

Identification and Annotation of Lipid Species in Metabolomics Studies Need Improvement Reply

Dunn, W. B., & Boeing, H. (2015). Identification and Annotation of Lipid Species in Metabolomics Studies Need Improvement Reply. CLINICAL CHEMISTRY, 61(12), 1544-1546. doi:10.1373/clinchem.2015.246843

DOI
10.1373/clinchem.2015.246843
Journal article

Metabolic profiling reveals potential metabolic markers associated with Hypoxia Inducible Factor-mediated signalling in hypoxic cancer cells

Armitage, E. G., Kotze, H. L., Allwood, J. W., Dunn, W. B., Goodacre, R., & Williams, K. J. (2015). Metabolic profiling reveals potential metabolic markers associated with Hypoxia Inducible Factor-mediated signalling in hypoxic cancer cells. SCIENTIFIC REPORTS, 5. doi:10.1038/srep15649

DOI
10.1038/srep15649
Journal article

Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma

Ludwig, C., Williams, D. S., Bartlett, D. B., Essex, S. J., McNee, G., Allwood, J. W., . . . Tennant, D. A. (2015). Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma. BLOOD CANCER JOURNAL, 5. doi:10.1038/bcj.2015.85

DOI
10.1038/bcj.2015.85
Journal article

Adipose tissue-specific androgen generation fuels an adverse metabolic phenotype in patients with polycystic ovary syndrome

O'Reilly, M., Kempegowda, P., Gathercole, L., Bujalska, I., Taylor, A., Hughes, B., . . . Arlt, W. (n.d.). Adipose tissue-specific androgen generation fuels an adverse metabolic phenotype in patients with polycystic ovary syndrome. Endocrine Abstracts. doi:10.1530/endoabs.38.oc1.4

DOI
10.1530/endoabs.38.oc1.4
Journal article

Dual 5-[alpha] reductase inhibition promotes hepatic lipid accumulation in man as a result of changes to lipid metabolism in adipose tissue and the liver

Hazlehurst, J., Oprescu, A., Nikolaou, N., Guida, R. D., Grinbergs, A., Davies, N., . . . Tomlinson, J. (n.d.). Dual 5-[alpha] reductase inhibition promotes hepatic lipid accumulation in man as a result of changes to lipid metabolism in adipose tissue and the liver. Endocrine Abstracts. doi:10.1530/endoabs.38.oc2.1

DOI
10.1530/endoabs.38.oc2.1
Journal article

A new strategy for MS/MS data acquisition applying multiple data dependent experiments on Orbitrap mass spectrometers in non-targeted metabolomic applications

Mullard, G., Allwood, J. W., Weber, R., Brown, M., Begley, P., Hollywood, K. A., . . . Dunn, W. B. (2015). A new strategy for MS/MS data acquisition applying multiple data dependent experiments on Orbitrap mass spectrometers in non-targeted metabolomic applications. METABOLOMICS, 11(5), 1068-1080. doi:10.1007/s11306-014-0763-6

DOI
10.1007/s11306-014-0763-6
Journal article

A new strategy for MS/MS data acquisition applying multiple data dependent experiments on Orbitrap mass spectrometers in non-targeted metabolomic applications (vol 11, pg 1068, 2015)

Mullard, G., Allwood, J. W., Weber, R. J. M., Brown, M., Begley, P., Hollywood, K. A., . . . Dunn, W. B. (2015). A new strategy for MS/MS data acquisition applying multiple data dependent experiments on Orbitrap mass spectrometers in non-targeted metabolomic applications (vol 11, pg 1068, 2015). METABOLOMICS, 11(5), 1081. doi:10.1007/s11306-015-0771-1

DOI
10.1007/s11306-015-0771-1
Journal article

Training needs in metabolomics

Weber, R. J. M., Winder, C. L., Larcombe, L. D., Dunn, W. B., & Viant, M. R. (2015). Training needs in metabolomics. METABOLOMICS, 11(4), 784-786. doi:10.1007/s11306-015-0815-6

DOI
10.1007/s11306-015-0815-6
Journal article

Antiphospholipid Antibodies Alter Cell-Death-Regulating Lipid Metabolites in First and Third Trimester Human Placentae

Pantham, P., Heazell, A. E. P., Mullard, G., Begley, P., Chen, Q., Brown, M., . . . Chamley, L. W. (2015). Antiphospholipid Antibodies Alter Cell-Death-Regulating Lipid Metabolites in First and Third Trimester Human Placentae. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 74(2), 181-199. doi:10.1111/aji.12387

DOI
10.1111/aji.12387
Journal article

Exploring the mode of action of dithranol therapy for psoriasis: a metabolomic analysis using HaCaT cells

Hollywood, K. A., Winder, C. L., Dunn, W. B., Xu, Y., Broadhurst, D., Griffiths, C. E. M., & Goodacre, R. (2015). Exploring the mode of action of dithranol therapy for psoriasis: a metabolomic analysis using HaCaT cells. MOLECULAR BIOSYSTEMS, 11(8), 2198-2209. doi:10.1039/c4mb00739e

DOI
10.1039/c4mb00739e
Journal article

MUSCLE: automated multi-objective evolutionary optimization of targeted LC-MS/MS analysis

Bradbury, J., Genta-Jouve, G., Allwood, J. W., Dunn, W. B., Goodacre, R., Knowles, J. D., . . . Viant, M. R. (2015). MUSCLE: automated multi-objective evolutionary optimization of targeted LC-MS/MS analysis. BIOINFORMATICS, 31(6), 975-977. doi:10.1093/bioinformatics/btu740

DOI
10.1093/bioinformatics/btu740
Journal article

Untargeted Metabolic Profiling Identifies Altered Serum Metabolites of Type 2 Diabetes Mellitus in a Prospective, Nested Case Control Study

Drogan, D., Dunn, W. B., Lin, W., Buijsse, B., Schulze, M. B., Langenberg, C., . . . Boeing, H. (2015). Untargeted Metabolic Profiling Identifies Altered Serum Metabolites of Type 2 Diabetes Mellitus in a Prospective, Nested Case Control Study. CLINICAL CHEMISTRY, 61(3), 487-497. doi:10.1373/clinchem.2014.228965

DOI
10.1373/clinchem.2014.228965
Journal article

Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy

Gehmlich, K., Dodd, M. S., Allwood, J. W., Kelly, M., Bellahcene, M., Lad, H. V., . . . Dunn, W. B. (2015). Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy. MOLECULAR BIOSYSTEMS, 11(2), 564-573. doi:10.1039/c4mb00594e

DOI
10.1039/c4mb00594e
Journal article

Molecular phenotyping of a UK population: defining the human serum metabolome

Dunn, W. B., Lin, W., Broadhurst, D., Begley, P., Brown, M., Zelena, E., . . . Kell, D. B. (2015). Molecular phenotyping of a UK population: defining the human serum metabolome. METABOLOMICS, 11(1), 9-26. doi:10.1007/s11306-014-0707-1

DOI
10.1007/s11306-014-0707-1
Journal article

Cryptococcal 3-Hydroxy Fatty Acids Protect Cells Against Amoebal Phagocytosis

Madu, U. L., Ogundeji, A. O., Mochochoko, B. M., Pohl, C. H., Albertyn, J., Swart, C. W., . . . Sebolai, O. M. (2015). Cryptococcal 3-Hydroxy Fatty Acids Protect Cells Against Amoebal Phagocytosis. FRONTIERS IN MICROBIOLOGY, 6. doi:10.3389/fmicb.2015.01351

DOI
10.3389/fmicb.2015.01351
Journal article

Discovery-based Studies of Mammalian Metabolomes with the Application of Mass Spectrometry Platforms

Dunn, W. B., Winder, C. L., & Carroll, K. M. (2015). Discovery-based Studies of Mammalian Metabolomes with the Application of Mass Spectrometry Platforms. METABOLIC PROFILING: DISEASE AND XENOBIOTICS, 21, 162-198. Retrieved from https://www.webofscience.com/

Journal article

Profiling of spatial metabolite distributions in wheat leaves under normal and nitrate limiting conditions

Allwood, J. W., Chandra, S., Xu, Y., Dunn, W. B., Correa, E., Hopkins, L., . . . Bowsher, C. G. (2015). Profiling of spatial metabolite distributions in wheat leaves under normal and nitrate limiting conditions. PHYTOCHEMISTRY, 115, 99-111. doi:10.1016/j.phytochem.2015.01.007

DOI
10.1016/j.phytochem.2015.01.007
Journal article

2014

Metabolomics Society Board election 2014: introduction of the new officers and directors

Dunn, W. (2014). Metabolomics Society Board election 2014: introduction of the new officers and directors. Metabolomics, 10(6), 1045-1046. doi:10.1007/s11306-014-0736-9

DOI
10.1007/s11306-014-0736-9
Journal article

Antiphospholipid antibodies alter cell-death-regulating lipid metabolites in first and third trimester human placentae

Pantham, P., Heazell, A., Mullard, G., Begley, P., Chen, Q., Brown, M., . . . Chamley, L. (2014). Antiphospholipid antibodies alter cell-death-regulating lipid metabolites in first and third trimester human placentae. Placenta, 35(9), A67-A68. doi:10.1016/j.placenta.2014.06.219

DOI
10.1016/j.placenta.2014.06.219
Journal article

The New Data Quality Task Group (DQTG): ensuring high quality data today and in the future

Bearden, D. W., Beger, R. D., Broadhurst, D., Dunn, W., Edison, A., Guillou, C., . . . Wilson, I. (2014). The New Data Quality Task Group (DQTG): ensuring high quality data today and in the future. METABOLOMICS, 10(4), 539-540. doi:10.1007/s11306-014-0679-1

DOI
10.1007/s11306-014-0679-1
Journal article

Metabolite identification: are you sure? And how do your peers gauge your confidence?

Creek, D. J., Dunn, W. B., Fiehn, O., Griffin, J. L., Hall, R. D., Lei, Z., . . . Wolfender, J. -L. (2014). Metabolite identification: are you sure? And how do your peers gauge your confidence?. METABOLOMICS, 10(3), 350-353. doi:10.1007/s11306-014-0656-8

DOI
10.1007/s11306-014-0656-8
Journal article

A metabolomics investigation into the effects of HIV protease inhibitors on HPV16 E6 expressing cervical carcinoma cells

Kim, D. -H., Allwood, J. W., Moore, R. E., Marsden-Edwards, E., Dunn, W. B., Xu, Y., . . . Goodacre, R. (2014). A metabolomics investigation into the effects of HIV protease inhibitors on HPV16 E6 expressing cervical carcinoma cells. MOLECULAR BIOSYSTEMS, 10(3), 398-411. doi:10.1039/c3mb70423h

DOI
10.1039/c3mb70423h
Journal article

HAMMER: automated operation of mass frontier to construct <i>in silico</i> mass spectral fragmentation libraries

Zhou, J., Weber, R. J. M., Allwood, J. W., Mistrik, R., Zhu, Z., Ji, Z., . . . Viant, M. R. (2014). HAMMER: automated operation of mass frontier to construct <i>in silico</i> mass spectral fragmentation libraries. BIOINFORMATICS, 30(4), 581-583. doi:10.1093/bioinformatics/btt711

DOI
10.1093/bioinformatics/btt711
Journal article

CHAPTER 6. Discovery-based Studies of Mammalian Metabolomes with the Application of Mass Spectrometry Platforms

Dunn, W. B., Winder, C. L., & Carroll, K. M. (2014). CHAPTER 6. Discovery-based Studies of Mammalian Metabolomes with the Application of Mass Spectrometry Platforms. In Issues in Toxicology (pp. 162-198). Royal Society of Chemistry. doi:10.1039/9781849735162-00162

DOI
10.1039/9781849735162-00162
Chapter

Evidence That Multiple Defects in Lipid Regulation Occur before Hyperglycemia during the Prodrome of Type-2 Diabetes

Anderson, S. G., Dunn, W. B., Banerjee, M., Brown, M., Broadhurst, D. I., Goodacre, R., . . . Cruickshank, J. K. (2014). Evidence That Multiple Defects in Lipid Regulation Occur before Hyperglycemia during the Prodrome of Type-2 Diabetes. PLOS ONE, 9(9). doi:10.1371/journal.pone.0103217

DOI
10.1371/journal.pone.0103217
Journal article

Tuulia Hyötyläinen and Susanne Wiedmer (Eds.): Chromatographic methods in metabolomics

Dunn, W. B. (2014). Tuulia Hyötyläinen and Susanne Wiedmer (Eds.): Chromatographic methods in metabolomics. Analytical and Bioanalytical Chemistry, 406(3), 659-660. doi:10.1007/s00216-013-7511-z

DOI
10.1007/s00216-013-7511-z
Journal article

Yeast cells with impaired drug resistance accumulate glycerol and glucose

Dikicioglu, D., Oc, S., Rash, B. M., Dunn, W. B., Pir, P., Kell, D. B., . . . Oliver, S. G. (2014). Yeast cells with impaired drug resistance accumulate glycerol and glucose. MOLECULAR BIOSYSTEMS, 10(1), 93-102. doi:10.1039/c2mb25512j

DOI
10.1039/c2mb25512j
Journal article

2013

A novel untargeted metabolomics correlation-based network analysis incorporating human metabolic reconstructions

Kotze, H. L., Armitage, E. G., Sharkey, K. J., Allwood, J. W., Dunn, W. B., Williams, K. J., & Goodacre, R. (2013). A novel untargeted metabolomics correlation-based network analysis incorporating human metabolic reconstructions. BMC SYSTEMS BIOLOGY, 7. doi:10.1186/1752-0509-7-107

DOI
10.1186/1752-0509-7-107
Journal article

The role of reporting standards for metabolite annotation and identification in metabolomic studies

Salek, R. M., Steinbeck, C., Viant, M. R., Goodacre, R., & Dunn, W. B. (2013). The role of reporting standards for metabolite annotation and identification in metabolomic studies. GIGASCIENCE, 2. doi:10.1186/2047-217X-2-13

DOI
10.1186/2047-217X-2-13
Journal article

Report on the 9th Annual International Conference of the Metabolomics Society

Ebbels, T., & Dunn, W. (2013). Report on the 9th Annual International Conference of the Metabolomics Society. Metabolomics, 9(5), 935-937. doi:10.1007/s11306-013-0579-9

DOI
10.1007/s11306-013-0579-9
Journal article

A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes

Smallbone, K., Messiha, H. L., Carroll, K. M., Winder, C. L., Malys, N., Dunn, W. B., . . . Mendes, P. (2013). A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes. FEBS LETTERS, 587(17), 2832-2841. doi:10.1016/j.febslet.2013.06.043

DOI
10.1016/j.febslet.2013.06.043
Journal article

Metabolomic analyses show that electron donor and acceptor ratios control anaerobic electron transfer pathways in <i>Shewanella oneidensis</i>

Wang, H., Correa, E., Dunn, W. B., Winder, C. L., Goodacre, R., & Lloyd, J. R. (2013). Metabolomic analyses show that electron donor and acceptor ratios control anaerobic electron transfer pathways in <i>Shewanella oneidensis</i>. METABOLOMICS, 9(3), 642-656. doi:10.1007/s11306-012-0488-3

DOI
10.1007/s11306-012-0488-3
Journal article

Platelet-derived deoxyribose-1-phosphate promotes endothelial cell motility in vitro and angiogenesis in vivo

Vara, D. S., Woodman, T., Dunn, W. B., Garonna, E., Campanella, M., Wheeler-Jones, C. P. D., & Pula, G. (2013). Platelet-derived deoxyribose-1-phosphate promotes endothelial cell motility in vitro and angiogenesis in vivo. Cardiovascular Pathology, 22(3), e51-e52. doi:10.1016/j.carpath.2013.01.076

DOI
10.1016/j.carpath.2013.01.076
Journal article

Autocrine amplification of integrin αIIbβ3 activation and platelet adhesive responses by deoxyribose-1-phosphate

Vara, D. S., Campanella, M., Canobbio, I., Dunn, W. B., Pizzorno, G., Hirano, M., & Pula, G. (2013). Autocrine amplification of integrin αIIbβ3 activation and platelet adhesive responses by deoxyribose-1-phosphate. THROMBOSIS AND HAEMOSTASIS, 109(6), 1108-1119. doi:10.1160/TH12-10-0751

DOI
10.1160/TH12-10-0751
Journal article

Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics

Dunn, W. B., Erban, A., Weber, R. J. M., Creek, D. J., Brown, M., Breitling, R., . . . Viant, M. R. (2013). Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics. METABOLOMICS, 9(1), S44-S66. doi:10.1007/s11306-012-0434-4

DOI
10.1007/s11306-012-0434-4
Journal article

Mass spectrometry and metabolomics: past, present and future

Dunn, W. B., & Hankemeier, T. (2013). Mass spectrometry and metabolomics: past, present and future. METABOLOMICS, 9(1), S1-S3. doi:10.1007/s11306-013-0507-z

DOI
10.1007/s11306-013-0507-z
Journal article

Diabetes - the Role of Metabolomics in the Discovery of New Mechanisms and Novel Biomarkers

Dunn, W. B. (2013). Diabetes - the Role of Metabolomics in the Discovery of New Mechanisms and Novel Biomarkers. Current Cardiovascular Risk Reports, 7(1), 25-32. doi:10.1007/s12170-012-0282-9

DOI
10.1007/s12170-012-0282-9
Journal article

Metabolomics and Its Role in the Study of Mammalian Systems

Dunn, W. B., Mamas, M., & Heazell, A. (2013). Metabolomics and Its Role in the Study of Mammalian Systems. In Unknown Book (pp. 345-377). Wiley. doi:10.1002/9783527655861.ch14

DOI
10.1002/9783527655861.ch14
Chapter

Biological Methods for Metabolic Research

Cebrián, A., Menchén, L., Sánchez-López, E., Casado-Vela, J., Díaz-Moralli, S., Cascante, M., . . . Lacal, J. C. (2013). Biological Methods for Metabolic Research. In Methodologies for Metabolomics (pp. 54-76). Cambridge University Press. doi:10.1017/cbo9780511996634.004

DOI
10.1017/cbo9780511996634.004
Chapter

Considerations in Sample Preparation, Collection, and Extraction Approaches Applied in Microbial, Plant, and Mammalian Metabolic Profiling

William Allwood, J., Winder, C. L., Dunn, W. B., & Goodacre, R. (2013). Considerations in Sample Preparation, Collection, and Extraction Approaches Applied in Microbial, Plant, and Mammalian Metabolic Profiling. In Methodologies for Metabolomics (pp. 79-118). Cambridge University Press. doi:10.1017/cbo9780511996634.006

DOI
10.1017/cbo9780511996634.006
Chapter

A community-driven global reconstruction of human metabolism

Thiele, I., Swainston, N., Fleming, R. M. T., Hoppe, A., Sahoo, S., Aurich, M. K., . . . Palsson, B. O. (2013). A community-driven global reconstruction of human metabolism. NATURE BIOTECHNOLOGY, 31(5), 419-+. doi:10.1038/nbt.2488

DOI
10.1038/nbt.2488
Journal article

2012

Liquid Chromatography-Mass Spectrometry Calibration Transfer and Metabolomics Data Fusion

Vaughan, A. A., Dunn, W. B., Allwood, J. W., Wedge, D. C., Blackhall, F. H., Whetton, A. D., . . . Goodacre, R. (2012). Liquid Chromatography-Mass Spectrometry Calibration Transfer and Metabolomics Data Fusion. ANALYTICAL CHEMISTRY, 84(22), 9848-9857. doi:10.1021/ac302227c

DOI
10.1021/ac302227c
Journal article

ChemInform Abstract: Fingerprinting Food: Current Technologies for the Detection of Food Adulteration and Contamination

Ellis, D. I., Brewster, V. L., Dunn, W. B., Allwood, J. W., Golovanov, A. P., & Goodacre, R. (2012). ChemInform Abstract: Fingerprinting Food: Current Technologies for the Detection of Food Adulteration and Contamination. ChemInform, 43(45). doi:10.1002/chin.201245273

DOI
10.1002/chin.201245273
Journal article

Fingerprinting food: current technologies for the detection of food adulteration and contamination

Ellis, D. I., Brewster, V. L., Dunn, W. B., Allwood, J. W., Golovanov, A. P., & Goodacre, R. (2012). Fingerprinting food: current technologies for the detection of food adulteration and contamination. CHEMICAL SOCIETY REVIEWS, 41(17), 5706-5727. doi:10.1039/c2cs35138b

DOI
10.1039/c2cs35138b
Journal article

Dupuytren's disease metabolite analyses reveals alterations following initial short-term fibroblast culturing

Rehman, S., Xu, Y., Dunn, W. B., Day, P. J. R., Westerhoff, H. V., Goodacre, R., & Bayat, A. (2012). Dupuytren's disease metabolite analyses reveals alterations following initial short-term fibroblast culturing. MOLECULAR BIOSYSTEMS, 8(9), 2274-2288. doi:10.1039/c2mb25173f

DOI
10.1039/c2mb25173f
Journal article

The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans

Dunn, W. B., Wilson, I. D., Nicholls, A. W., & Broadhurst, D. (2012). The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans. BIOANALYSIS, 4(18), 2249-2264. doi:10.4155/BIO.12.204

DOI
10.4155/BIO.12.204
Journal article

A Metabolomic Approach Identifies Differences in Maternal Serum in Third Trimester Pregnancies That End in Poor Perinatal Outcome

Heazell, A. E. P., Bernatavicius, G., Warrander, L., Brown, M. C., & Dunn, W. B. (2012). A Metabolomic Approach Identifies Differences in Maternal Serum in Third Trimester Pregnancies That End in Poor Perinatal Outcome. REPRODUCTIVE SCIENCES, 19(8), 863-875. doi:10.1177/1933719112438446

DOI
10.1177/1933719112438446
Journal article

The metabolome of human placental tissue: investigation of first trimester tissue and changes related to preeclampsia in late pregnancy

Dunn, W. B., Brown, M., Worton, S. A., Davies, K., Jones, R. L., Kell, D. B., & Heazell, A. E. P. (2012). The metabolome of human placental tissue: investigation of first trimester tissue and changes related to preeclampsia in late pregnancy. METABOLOMICS, 8(4), 579-597. doi:10.1007/s11306-011-0348-6

DOI
10.1007/s11306-011-0348-6
Journal article

Improving metabolic flux predictions using absolute gene expression data

Lee, D., Smallbone, K., Dunn, W. B., Murabito, E., Winder, C. L., Kell, D. B., . . . Swainston, N. (2012). Improving metabolic flux predictions using absolute gene expression data. BMC SYSTEMS BIOLOGY, 6. doi:10.1186/1752-0509-6-73

DOI
10.1186/1752-0509-6-73
Journal article

Proof-of-principle study to detect metabolic changes in peritoneal dialysis effluent in patients who develop encapsulating peritoneal sclerosis

Dunn, W. B., Summers, A., Brown, M., Goodacre, R., Lambie, M., Johnson, T., . . . Brenchley, P. (2012). Proof-of-principle study to detect metabolic changes in peritoneal dialysis effluent in patients who develop encapsulating peritoneal sclerosis. NEPHROLOGY DIALYSIS TRANSPLANTATION, 27(6), 2502-2510. doi:10.1093/ndt/gfr662

DOI
10.1093/ndt/gfr662
Journal article

Short- and long-term dynamic responses of the metabolic network and gene expression in yeast to a transient change in the nutrient environment

Dikicioglu, D., Dunn, W. B., Kell, D. B., Kirdar, B., & Oliver, S. G. (2012). Short- and long-term dynamic responses of the metabolic network and gene expression in yeast to a transient change in the nutrient environment. MOLECULAR BIOSYSTEMS, 8(6), 1760-1774. doi:10.1039/c2mb05443d

DOI
10.1039/c2mb05443d
Journal article

Metabolic profiles identify markers of catch-up growth in children born small for gestational age (SGA)

Butcher, I., Whatmore, A., Bonshek, C., Shaikh, G., Dunn, W., Brown, M., . . . Clayton, P. (2012). Metabolic profiles identify markers of catch-up growth in children born small for gestational age (SGA). Archives of Disease in Childhood, 97(Suppl 1), A102.1-A102. doi:10.1136/archdischild-2012-301885.240

DOI
10.1136/archdischild-2012-301885.240
Journal article

Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA)

Ugarte, M., Brown, M., Hollywood, K. A., Cooper, G. J., Bishop, P. N., & Dunn, W. B. (2012). Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA). GENOME MEDICINE, 4. doi:10.1186/gm334

DOI
10.1186/gm334
Journal article

Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets (vol 27, pg 1108, 2011)

Brown, M., Wedge, D. C., Goodacre, R., Kell, D. B., Baker, P. N., Kenny, L. C., . . . Dunn, W. B. (2012). Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets (vol 27, pg 1108, 2011). BIOINFORMATICS, 28(1), 149. doi:10.1093/bioinformatics/btr601

DOI
10.1093/bioinformatics/btr601
Journal article

2011

P3-09-02: Intermittent Dietary Carbohydrate Restriction Enables Weight Loss and Reduces Breast Cancer Risk Biomarkers.

Harvie, M., Wright, C., Pegington, M., Mitchell, E., Evans, D. G., Jebb, S., . . . Howell, A. (2011). P3-09-02: Intermittent Dietary Carbohydrate Restriction Enables Weight Loss and Reduces Breast Cancer Risk Biomarkers.. Cancer Research, 71(24_Supplement). doi:10.1158/0008-5472.sabcs11-p3-09-02

DOI
10.1158/0008-5472.sabcs11-p3-09-02
Journal article

Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

Dunn, W. B., Broadhurst, D. I., Atherton, H. J., Goodacre, R., & Griffin, J. L. (2011). Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy. CHEMICAL SOCIETY REVIEWS, 40(1), 387-426. doi:10.1039/b906712b

DOI
10.1039/b906712b
Journal article

Absolute Quantification of the Glycolytic Pathway in Yeast: DEPLOYMENT OF A COMPLETE QconCAT APPROACH

Carroll, K. M., Simpson, D. M., Eyers, C. E., Knight, C. G., Brownridge, P., Dunn, W. B., . . . Beynon, R. J. (2011). Absolute Quantification of the Glycolytic Pathway in Yeast: DEPLOYMENT OF A COMPLETE QconCAT APPROACH. MOLECULAR & CELLULAR PROTEOMICS, 10(12). doi:10.1074/mcp.M111.007633

DOI
10.1074/mcp.M111.007633
Journal article

Integration of metabolomics in heart disease and diabetes research: current achievements and future outlook

Dunn, W. B., Goodacre, R., Neyses, L., & Mamas, M. (2011). Integration of metabolomics in heart disease and diabetes research: current achievements and future outlook. BIOANALYSIS, 3(19), 2205-2222. doi:10.4155/BIO.11.223

DOI
10.4155/BIO.11.223
Journal article

Is Serum or Plasma More Appropriate for Intersubject Comparisons in Metabolomic Studies? An Assessment in Patients with Small-Cell Lung Cancer

Wedge, D. C., Allwood, J. W., Dunn, W., Vaughan, A. A., Simpson, K., Brown, M., . . . Goodacre, R. (2011). Is Serum or Plasma More Appropriate for Intersubject Comparisons in Metabolomic Studies? An Assessment in Patients with Small-Cell Lung Cancer. ANALYTICAL CHEMISTRY, 83(17), 6689-6697. doi:10.1021/ac2012224

DOI
10.1021/ac2012224
Journal article

Metabolomic approaches reveal that cell wall modifications play a major role in ethylene-mediated resistance against <i>Botrytis cinerea</i>

Lloyd, A. J., Allwood, J. W., Winder, C. L., Dunn, W. B., Heald, J. K., Cristescu, S. M., . . . Mur, L. A. J. (2011). Metabolomic approaches reveal that cell wall modifications play a major role in ethylene-mediated resistance against <i>Botrytis cinerea</i>. PLANT JOURNAL, 67(5), 852-868. doi:10.1111/j.1365-313X.2011.04639.x

DOI
10.1111/j.1365-313X.2011.04639.x
Journal article

Metabolic Profiling Uncovers a Phenotypic Signature of Small for Gestational Age in Early Pregnancy

Horgan, R. P., Broadhurst, D. I., Walsh, S. K., Dunn, W. B., Brown, M., Roberts, C. T., . . . Kenny, L. C. (2011). Metabolic Profiling Uncovers a Phenotypic Signature of Small for Gestational Age in Early Pregnancy. JOURNAL OF PROTEOME RESEARCH, 10(8), 3660-3673. doi:10.1021/pr2002897

DOI
10.1021/pr2002897
Journal article

TARDIS-based microbial metabolomics: time and relative differences in systems

Winder, C. L., Dunn, W. B., & Goodacre, R. (2011). TARDIS-based microbial metabolomics: time and relative differences in systems. TRENDS IN MICROBIOLOGY, 19(7), 315-322. doi:10.1016/j.tim.2011.05.004

DOI
10.1016/j.tim.2011.05.004
Journal article

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

Dunn, W. B., Broadhurst, D., Begley, P., Zelena, E., Francis-McIntyre, S., Anderson, N., . . . Goodacre, R. (2011). Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. NATURE PROTOCOLS, 6(7), 1060-1083. doi:10.1038/nprot.2011.335

DOI
10.1038/nprot.2011.335
Journal article

Extensive metabolic cross-talk in melon fruit revealed by spatial and developmental combinatorial metabolomics

Moing, A., Aharoni, A., Biais, B., Rogachev, I., Meir, S., Brodsky, L., . . . Hall, R. D. (2011). Extensive metabolic cross-talk in melon fruit revealed by spatial and developmental combinatorial metabolomics. NEW PHYTOLOGIST, 190(3), 683-696. doi:10.1111/j.1469-8137.2010.03626.x

DOI
10.1111/j.1469-8137.2010.03626.x
Journal article

ChemInform Abstract: Systems Level Studies of Mammalian Metabolomes: The Roles of Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy

Dunn, W. B., Broadhurst, D. I., Atherton, H. J., Goodacre, R., & Griffin, J. L. (2011). ChemInform Abstract: Systems Level Studies of Mammalian Metabolomes: The Roles of Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy. ChemInform, 42(17). doi:10.1002/chin.201117279

DOI
10.1002/chin.201117279
Journal article

ATR (ataxia telangiectasia mutated- and Rad3-related kinase) is activated by mild hypothermia in mammalian cells and subsequently activates p53

Roobol, A., Roobol, J., Carden, M. J., Bastide, A., Willis, A. E., Dunn, W. B., . . . Smales, C. M. (2011). ATR (ataxia telangiectasia mutated- and Rad3-related kinase) is activated by mild hypothermia in mammalian cells and subsequently activates p53. BIOCHEMICAL JOURNAL, 435, 499-508. doi:10.1042/BJ20101303

DOI
10.1042/BJ20101303
Journal article

Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets

Brown, M., Wedge, D. C., Goodacre, R., Kell, D. B., Baker, P. N., Kenny, L. C., . . . Dunn, W. B. (2011). Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets. BIOINFORMATICS, 27(8), 1108-1112. doi:10.1093/bioinformatics/btr079

DOI
10.1093/bioinformatics/btr079
Journal article

Review: The effects of oxygen on normal and pre-eclamptic placental tissue - insights from metabolomics

Heazell, A. E. P., Brown, M., Worton, S. A., & Dunn, W. B. (2011). Review: The effects of oxygen on normal and pre-eclamptic placental tissue - insights from metabolomics. PLACENTA, 32, S119-S124. doi:10.1016/j.placenta.2010.12.001

DOI
10.1016/j.placenta.2010.12.001
Journal article

Metabolic profiling of meat: assessment of pork hygiene and contamination with <i>Salmonella typhimurium</i>

Xu, Y., Cheung, W., Winder, C. L., Dunn, W. B., & Goodacre, R. (2011). Metabolic profiling of meat: assessment of pork hygiene and contamination with <i>Salmonella typhimurium</i>. ANALYST, 136(3), 508-514. doi:10.1039/c0an00394h

DOI
10.1039/c0an00394h
Journal article

Adapting <i>in vitro</i> dual perfusion of the human placenta to soluble oxygen tensions associated with normal and pre-eclamptic pregnancy

Soydemir, F., Kuruvilla, S., Brown, M., Dunn, W., Day, P., Crocker, I. P., . . . Brownbill, P. (2011). Adapting <i>in vitro</i> dual perfusion of the human placenta to soluble oxygen tensions associated with normal and pre-eclamptic pregnancy. LABORATORY INVESTIGATION, 91(2), 181-189. doi:10.1038/labinvest.2010.171

DOI
10.1038/labinvest.2010.171
Journal article

Fit-for-Purpose Quenching and Extraction Protocols for Metabolic Profiling of Yeast Using Chromatography-Mass Spectrometry Platforms

Winder, C. L., & Dunn, W. B. (2011). Fit-for-Purpose Quenching and Extraction Protocols for Metabolic Profiling of Yeast Using Chromatography-Mass Spectrometry Platforms. In YEAST SYSTEMS BIOLOGY: METHODS AND PROTOCOLS (Vol. 759, pp. 225-238). doi:10.1007/978-1-61779-173-4_14

DOI
10.1007/978-1-61779-173-4_14
Chapter

MASS SPECTROMETRY IN SYSTEMS BIOLOGY: AN INTRODUCTION

Dunn, W. B. (2011). MASS SPECTROMETRY IN SYSTEMS BIOLOGY: AN INTRODUCTION. In METHODS IN ENZYMOLOGY, VOL 500 (Vol. 500, pp. 15-35). doi:10.1016/B978-0-12-385118-5.00002-5

DOI
10.1016/B978-0-12-385118-5.00002-5
Chapter

Mass Spectrometry in Systems Biology

Dunn, W. B. (2011). Mass Spectrometry in Systems Biology. In Methods in Enzymology (pp. 15-35). Elsevier. doi:10.1016/b978-0-12-385118-5.00002-5

DOI
10.1016/b978-0-12-385118-5.00002-5
Chapter

SAMPLE PREPARATION RELATED TO THE INTRACELLULAR METABOLOME OF YEAST: METHODS FOR QUENCHING, EXTRACTION, AND METABOLITE QUANTITATION

Dunn, W. B., & Winder, C. L. (2011). SAMPLE PREPARATION RELATED TO THE INTRACELLULAR METABOLOME OF YEAST: METHODS FOR QUENCHING, EXTRACTION, AND METABOLITE QUANTITATION. In METHODS IN ENZYMOLOGY, VOL 500 (Vol. 500, pp. 277-297). doi:10.1016/B978-0-12-385118-5.00015-3

DOI
10.1016/B978-0-12-385118-5.00015-3
Chapter

Sample Preparation Related to the Intracellular Metabolome of Yeast

Dunn, W. B., & Winder, C. L. (2011). Sample Preparation Related to the Intracellular Metabolome of Yeast. In Methods in Enzymology (pp. 277-297). Elsevier. doi:10.1016/b978-0-12-385118-5.00015-3

DOI
10.1016/b978-0-12-385118-5.00015-3
Chapter

The role of metabolites and metabolomics in clinically applicable biomarkers of disease

Mamas, M., Dunn, W. B., Neyses, L., & Goodacre, R. (2011). The role of metabolites and metabolomics in clinically applicable biomarkers of disease. ARCHIVES OF TOXICOLOGY, 85(1), 5-17. doi:10.1007/s00204-010-0609-6

DOI
10.1007/s00204-010-0609-6
Journal article

2010

Paracrine Stimulation of Endothelial Cell Motility and Angiogenesis by Platelet-Derived Deoxyribose-1-Phosphate

Pula, G., Garonna, E., Dunn, W. B., Hirano, M., Pizzorno, G., Campanella, M., . . . Wheeler-Jones, C. P. D. (2010). Paracrine Stimulation of Endothelial Cell Motility and Angiogenesis by Platelet-Derived Deoxyribose-1-Phosphate. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 30(12), 2631-U566. doi:10.1161/ATVBAHA.110.215855

DOI
10.1161/ATVBAHA.110.215855
Journal article

Systematic integration of experimental data and models in systems biology

Li, P., Dada, J. O., Jameson, D., Spasic, I., Swainston, N., Carroll, K., . . . Paton, N. W. (2010). Systematic integration of experimental data and models in systems biology. BMC BIOINFORMATICS, 11. doi:10.1186/1471-2105-11-582

DOI
10.1186/1471-2105-11-582
Journal article

Further developments towards a genome-scale metabolic model of yeast

Dobson, P. D., Smallbone, K., Jameson, D., Simeonidis, E., Lanthaler, K., Pir, P., . . . Mendes, P. (2010). Further developments towards a genome-scale metabolic model of yeast. BMC SYSTEMS BIOLOGY, 4. doi:10.1186/1752-0509-4-145

DOI
10.1186/1752-0509-4-145
Journal article

Changes in the Metabolic Footprint of Placental Explant-Conditioned Medium Cultured in Different Oxygen Tensions from Placentas of Small for Gestational Age and Normal Pregnancies

Horgan, R. P., Broadhurst, D. I., Dunn, W. B., Brown, M., Heazell, A. E. P., Kell, D. B., . . . Kenny, L. C. (2010). Changes in the Metabolic Footprint of Placental Explant-Conditioned Medium Cultured in Different Oxygen Tensions from Placentas of Small for Gestational Age and Normal Pregnancies. PLACENTA, 31(10), 893-901. doi:10.1016/j.placenta.2010.07.002

DOI
10.1016/j.placenta.2010.07.002
Journal article

M7.4 Uncovering the metabolomic signature of intrauterine growth restriction in early pregnancy: search, discovery and validation

Broadhurst, D., Dunn, W., Horgan, R., Dekker, G., & Kenny, L. (2010). M7.4 Uncovering the metabolomic signature of intrauterine growth restriction in early pregnancy: search, discovery and validation. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 1, S5. doi:10.1016/s2210-7789(10)60034-7

DOI
10.1016/s2210-7789(10)60034-7
Journal article

Robust Early Pregnancy Prediction of Later Preeclampsia Using Metabolomic Biomarkers

Kenny, L. C., Broadhurst, D. I., Dunn, W., Brown, M., North, R. A., McCowan, L., . . . Baker, P. N. (2010). Robust Early Pregnancy Prediction of Later Preeclampsia Using Metabolomic Biomarkers. HYPERTENSION, 56(4), 741-749. doi:10.1161/HYPERTENSIONAHA.110.157297

DOI
10.1161/HYPERTENSIONAHA.110.157297
Journal article

BAS/BSCR3 Partial reconstruction of myocardial metabolic pathways following analysis of peripheral serum using metabolomics in early cardiac ischaemia

Mamas, M. A., Dunn, W. B., Broadhurst, D., Chacko, S., Brown, M., El-Omar, M., . . . Neyses, L. (2010). BAS/BSCR3 Partial reconstruction of myocardial metabolic pathways following analysis of peripheral serum using metabolomics in early cardiac ischaemia. Heart, 96(17), e13. doi:10.1136/hrt.2010.205781.14

DOI
10.1136/hrt.2010.205781.14
Journal article

Metabolic changes in plasma from the umbilical cord of small for gestational age babies and from a rat model of placental insufficiency

Horgan, R., Broadhurst, D., Dunn, W., Walsh, S., Brown, M., Kell, D., . . . Kenny, L. (2010). Metabolic changes in plasma from the umbilical cord of small for gestational age babies and from a rat model of placental insufficiency. Archives of Disease in Childhood - Fetal and Neonatal Edition, 95(Supplement 1), Fa14-Fa15. doi:10.1136/adc.2010.189746.10

DOI
10.1136/adc.2010.189746.10
Journal article

T1259 Serum Metabolite Profiles Differentiate Crohn's Disease From Ulcerative Colitis and From Healthy Controls

Johnston, C., Dunn, W., Broadhurst, D., Brown, M., Goodacre, R., Campbell, S., . . . Watson, A. J. (2010). T1259 Serum Metabolite Profiles Differentiate Crohn's Disease From Ulcerative Colitis and From Healthy Controls. Gastroenterology, 138(5), S-523. doi:10.1016/s0016-5085(10)62414-6

DOI
10.1016/s0016-5085(10)62414-6
Journal article

SERUM METABOLITE PROFILES DIFFERENTIATE CROHN'S DISEASE FROM ULCERATIVE COLITIS AND FROM HEALTHY CONTROLS

Johnston, C., Dunn, W., Broadhurst, D., Brown, M., Makin, A., Campbell, S., . . . Watson, A. J. M. (2010). SERUM METABOLITE PROFILES DIFFERENTIATE CROHN'S DISEASE FROM ULCERATIVE COLITIS AND FROM HEALTHY CONTROLS. In GUT Vol. 59 (pp. A61). doi:10.1136/gut.2009.209031s

DOI
10.1136/gut.2009.209031s
Conference Paper

Assessment of adaptive focused acoustics <i>versus</i> manual vortex/freeze-thaw for intracellular metabolite extraction from <i>Streptomyces lividans</i> producing recombinant proteins using GC-MS and multi-block principal component analysis

Kassama, Y., Xu, Y., Dunn, W. B., Geukens, N., Anne, J., & Goodacre, R. (2010). Assessment of adaptive focused acoustics <i>versus</i> manual vortex/freeze-thaw for intracellular metabolite extraction from <i>Streptomyces lividans</i> producing recombinant proteins using GC-MS and multi-block principal component analysis. ANALYST, 135(5), 934-942. doi:10.1039/b918163f

DOI
10.1039/b918163f
Journal article

Metabolite Identification in Metabolomics

Dunn, W. (2010). Metabolite Identification in Metabolomics. GENETIC ENGINEERING & BIOTECHNOLOGY NEWS, 30(8), 36-37. Retrieved from https://www.webofscience.com/

Journal article

2009

Systems Biology: The elements and principles of Life

Westerhoff, H. V., Winder, C., Messiha, H., Simeonidis, E., Adamczyk, M., Verma, M., . . . Dunn, W. (2009). Systems Biology: The elements and principles of Life. FEBS LETTERS, 583(24), 3882-3890. doi:10.1016/j.febslet.2009.11.018

DOI
10.1016/j.febslet.2009.11.018
Journal article

Inter-laboratory reproducibility of fast gas chromatography-electron impact-time of flight mass spectrometry (GC-EI-TOF/MS) based plant metabolomics

Allwood, J. W., Erban, A., de Koning, S., Dunn, W. B., Luedemann, A., Lommen, A., . . . Goodacre, R. (2009). Inter-laboratory reproducibility of fast gas chromatography-electron impact-time of flight mass spectrometry (GC-EI-TOF/MS) based plant metabolomics. METABOLOMICS, 5(4), 479-496. doi:10.1007/s11306-009-0169-z

DOI
10.1007/s11306-009-0169-z
Journal article

Changes in the Metabolic Footprint of Placental Explant-Conditioned Culture Medium Identifies Metabolic Disturbances Related to Hypoxia and Pre-Eclampsia

Dunn, W. B., Brown, M., Worton, S. A., Crocker, I. P., Broadhurst, D., Horgan, R., . . . Heazell, A. E. P. (2009). Changes in the Metabolic Footprint of Placental Explant-Conditioned Culture Medium Identifies Metabolic Disturbances Related to Hypoxia and Pre-Eclampsia. PLACENTA, 30(11), 974-980. doi:10.1016/j.placenta.2009.08.008

DOI
10.1016/j.placenta.2009.08.008
Journal article

Development and Performance of a Gas Chromatography-Time-of-Flight Mass Spectrometry Analysis for Large-Scale Nontargeted Metabolomic Studies of Human Serum

Begley, P., Francis-McIntyre, S., Dunn, W. B., Broadhurst, D. I., Halsall, A., Tseng, A., . . . Kell, D. B. (2009). Development and Performance of a Gas Chromatography-Time-of-Flight Mass Spectrometry Analysis for Large-Scale Nontargeted Metabolomic Studies of Human Serum. ANALYTICAL CHEMISTRY, 81(16), 7038-7046. doi:10.1021/ac9011599

DOI
10.1021/ac9011599
Journal article

Biomarkers of Dietary Energy Restriction in Women at Increased Risk of Breast Cancer

Ong, K. R., Sims, A. H., Harvie, M., Chapman, M., Dunn, W. B., Broadhurst, D., . . . Howell, A. (2009). Biomarkers of Dietary Energy Restriction in Women at Increased Risk of Breast Cancer. CANCER PREVENTION RESEARCH, 2(8), 720-731. doi:10.1158/1940-6207.CAPR-09-0008

DOI
10.1158/1940-6207.CAPR-09-0008
Journal article

P4‐310: Serum Metabolite Biomarkers In Alzheimer's Disease

Purandare, N., Zubair, M., Xu, Y., Broadhurst, D., Dunn, W. B., Begley, P., . . . Goodacre, R. (2009). P4‐310: Serum Metabolite Biomarkers In Alzheimer's Disease. Alzheimer's &amp; Dementia, 5(4S_Part_17). doi:10.1016/j.jalz.2009.07.089

DOI
10.1016/j.jalz.2009.07.089
Journal article

<SUP>1</SUP>H NMR, GC-EI-TOFMS, and Data Set Correlation for Fruit Metabolomics: Application to Spatial Metabolite Analysis in Melon

Biais, B., Allwood, J. W., Deborde, C., Xu, Y., Maucourt, M., Beauvoit, B., . . . Moing, A. (2009). <SUP>1</SUP>H NMR, GC-EI-TOFMS, and Data Set Correlation for Fruit Metabolomics: Application to Spatial Metabolite Analysis in Melon. ANALYTICAL CHEMISTRY, 81(8), 2884-2894. doi:10.1021/ac9001996

DOI
10.1021/ac9001996
Journal article

Development of a Robust and Repeatable UPLC-MS Method for the Long-Term Metabolomic Study of Human Serum

Zelena, E., Dunn, W. B., Broadhurst, D., Francis-McIntyre, S., Carroll, K. M., Begley, P., . . . Kellt, D. B. (2009). Development of a Robust and Repeatable UPLC-MS Method for the Long-Term Metabolomic Study of Human Serum. ANALYTICAL CHEMISTRY, 81(4), 1357-1364. doi:10.1021/ac8019366

DOI
10.1021/ac8019366
Journal article

Effective Quenching Processes for Physiologically Valid Metabolite Profiling of Suspension Cultured Mammalian Cells

Sellick, C. A., Hansen, R., Maqsood, A. R., Dunn, W. B., Stephens, G. M., Goodacre, R., & Dickson, A. J. (2009). Effective Quenching Processes for Physiologically Valid Metabolite Profiling of Suspension Cultured Mammalian Cells. ANALYTICAL CHEMISTRY, 81(1), 174-183. doi:10.1021/ac8016899

DOI
10.1021/ac8016899
Journal article

Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics

Brown, M., Dunn, W. B., Dobson, P., Patel, Y., Winder, C. L., Francis-McIntyre, S., . . . Kell, D. B. (2009). Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics. ANALYST, 134(7), 1322-1332. doi:10.1039/b901179j

DOI
10.1039/b901179j
Journal article

2008

A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology

Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., . . . Kell, D. B. (2008). A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology. NATURE BIOTECHNOLOGY, 26(10), 1155-1160. doi:10.1038/nbt1492

DOI
10.1038/nbt1492
Journal article

Metabolic profiling of serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system

Dunn, W. B., Broadhurst, D., Brown, M., Baker, P. N., Redman, C. W. G., Kenny, L. C., & Kell, D. B. (2008). Metabolic profiling of serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 871(2), 288-298. doi:10.1016/j.jchromb.2008.03.021

DOI
10.1016/j.jchromb.2008.03.021
Journal article

Analysis of the metabolic footprint and tissue metabolome of placental villous explants cultured at different oxygen tensions reveals novel redox biomarkers

Heazell, A. E. P., Brown, M., Dunn, W. B., Worton, S. A., Crocker, I. P., Baker, P. N., & Kell, D. B. (2008). Analysis of the metabolic footprint and tissue metabolome of placental villous explants cultured at different oxygen tensions reveals novel redox biomarkers. PLACENTA, 29(8), 691-698. doi:10.1016/j.placenta.2008.05.002

DOI
10.1016/j.placenta.2008.05.002
Journal article

Genomics in cardiac metabolism

Samuel, J. -L., Schaub, M. C., Zaugg, M., Mamas, M., Dunn, W. B., & Swynghedauw, B. (2008). Genomics in cardiac metabolism. CARDIOVASCULAR RESEARCH, 79(2), 218-227. doi:10.1093/cvr/cvn061

DOI
10.1093/cvr/cvn061
Journal article

Detection and identification of novel metabolomic biomarkers in preeclampsia

Kenny, L. C., Broadhurst, D., Brown, M., Dunn, W. B., Redman, C. W. G., Kill, D. B., & Baker, P. N. (2008). Detection and identification of novel metabolomic biomarkers in preeclampsia. REPRODUCTIVE SCIENCES, 15(6), 591-597. doi:10.1177/1933719108316908

DOI
10.1177/1933719108316908
Journal article

Relatedness of medically important strains of <i>Saccharomyces cerevisiae</i> as revealed by phylogenetics and metabolomics

MacKenzie, D. A., Defernez, M., Dunn, W. B., Brown, M., Fuller, L. J., Seco de Herrera, S. R. M., . . . Roberts, I. N. (2008). Relatedness of medically important strains of <i>Saccharomyces cerevisiae</i> as revealed by phylogenetics and metabolomics. YEAST, 25(7), 501-512. doi:10.1002/yea.1601

DOI
10.1002/yea.1601
Journal article

Global metabolic profiling of <i>Escherichia coli</i> cultures:: An evaluation of methods for quenching and extraction of intracellular metabolites

Winder, C. L., Dunn, W. B., Schuler, S., Broadhurst, D., Jarvis, R., Stephens, G. M., & Goodacre, R. (2008). Global metabolic profiling of <i>Escherichia coli</i> cultures:: An evaluation of methods for quenching and extraction of intracellular metabolites. ANALYTICAL CHEMISTRY, 80(8), 2939-2948. doi:10.1021/ac7023409

DOI
10.1021/ac7023409
Journal article

A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols

Dunn, W. B., Broadhurst, D., Ellis, D. I., Brown, M., Halsall, A., O'Hagan, S., . . . Kell, D. B. (2008). A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 37, 23-30. doi:10.1093/ije/dym281

DOI
10.1093/ije/dym281
Journal article

Genomics in cardiac metabolism

Samuel, J. L., Schaub, M. C., Zaugg, M., Mamas, M., Dunn, W. B., & Swynghedauw, B. (2008). Genomics in cardiac metabolism. Journal of Molecular and Cellular Cardiology, 44(4), 807-808. doi:10.1016/j.yjmcc.2008.02.230

DOI
10.1016/j.yjmcc.2008.02.230
Journal article

Comparative evaluation of software for deconvolution of metabolomics data based on GC-TOF-MS

Lu, H., Dunn, W. B., Shen, H., Kell, D. B., & Liang, Y. (2008). Comparative evaluation of software for deconvolution of metabolomics data based on GC-TOF-MS. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 27(3), 215-227. doi:10.1016/j.trac.2007.11.004

DOI
10.1016/j.trac.2007.11.004
Journal article

Metabolite profiles of interacting mycelial fronts differ for pairings of the wood decay basidiomycete fungus, <i>Stereum hirsutum</i> with its competitors <i>Coprinus micaceus</i> and <i>Coprinus disseminatus</i>

Peiris, D., Dunn, W. B., Brown, M., Kell, D. B., Roy, I., & Hedger, J. N. (2008). Metabolite profiles of interacting mycelial fronts differ for pairings of the wood decay basidiomycete fungus, <i>Stereum hirsutum</i> with its competitors <i>Coprinus micaceus</i> and <i>Coprinus disseminatus</i>. METABOLOMICS, 4(1), 52-62. doi:10.1007/s11306-007-0100-4

DOI
10.1007/s11306-007-0100-4
Journal article

Current trends and future requirements for the mass spectrometric investigation of microbial, mammalian and plant metabolomes

Dunn, W. B. (2008). Current trends and future requirements for the mass spectrometric investigation of microbial, mammalian and plant metabolomes. PHYSICAL BIOLOGY, 5(1). doi:10.1088/1478-3975/5/1/011001

DOI
10.1088/1478-3975/5/1/011001
Journal article

2007

Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate

Dunn, W. B., Broadhurst, D. I., Deepak, S. M., Buch, M. H., McDowell, G., Spasic, I., . . . Neyses, L. (2007). Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate. METABOLOMICS, 3(4), 413-426. doi:10.1007/s11306-007-0063-5

DOI
10.1007/s11306-007-0063-5
Journal article

Metabolic fingerprinting as a diagnostic tool

Ellis, D. I., Dunn, W. B., Griffin, J. L., Allwood, J. W., & Goodacre, R. (2007). Metabolic fingerprinting as a diagnostic tool. PHARMACOGENOMICS, 8(9), 1243-1266. doi:10.2217/14622416.8.9.1243

DOI
10.2217/14622416.8.9.1243
Journal article

Transcriptional and metabolic response of <i>Saccharomyces cerevisiae</i> to a nutritional perturbation when under stress

Dikicioglu, D., Rash, B., Dunn, W. B., Pir, P., Hayes, A., Kell, D. B., . . . Oliver, S. G. (2007). Transcriptional and metabolic response of <i>Saccharomyces cerevisiae</i> to a nutritional perturbation when under stress. In JOURNAL OF BIOTECHNOLOGY Vol. 131 (pp. S14-S15). doi:10.1016/j.jbiotec.2007.07.028

DOI
10.1016/j.jbiotec.2007.07.028
Conference Paper

Metabolic footprinting as a tool for discriminating between brewing yeasts

Pope, G. A., MacKenzie, D. A., Defemez, M., Aroso, M. A. M. M., Fuller, L. J., Mellon, F. A., . . . Roberts, I. N. (2007). Metabolic footprinting as a tool for discriminating between brewing yeasts. YEAST, 24(8), 667-679. doi:10.1002/yea.1499

DOI
10.1002/yea.1499
Journal article

Closed-loop, multiobjective optimization of two-dimensional gas chromatography/mass spectrometry for serum metabolomics

Hagan, S. O., Dunn, W. B., Knowles, J. D., Broadhurst, D., Williams, R., Ashworth, J. J., . . . Kell, D. B. (2007). Closed-loop, multiobjective optimization of two-dimensional gas chromatography/mass spectrometry for serum metabolomics. ANALYTICAL CHEMISTRY, 79(2), 464-476. doi:10.1021/ac061443+

DOI
10.1021/ac061443+
Journal article

2006

MeMo: a hybrid SQL/XML approach to metabolomic data management for functional genomics

Spasic, I., Dunn, W. B., Velarde, G., Tseng, A., Jenkins, H., Hardy, N., . . . Kell, D. B. (2006). MeMo: a hybrid SQL/XML approach to metabolomic data management for functional genomics. BMC BIOINFORMATICS, 7. doi:10.1186/1471-2105-7-281

DOI
10.1186/1471-2105-7-281
Journal article

Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles

Underwood, B. R., Broadhurst, D., Dunn, W. B., Ellis, D. I., Michell, A. W., Vacher, C., . . . Rubinsztein, D. C. (2006). Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles. BRAIN, 129, 877-886. doi:10.1093/brain/awl027

DOI
10.1093/brain/awl027
Journal article

2005

A laser desorption ionisation mass spectrometry approach for high throughput metabolomics

Vaidyanathan, S., Jones, D., Broadhurst, D. I., Ellis, J., Jenkins, T., Dunn, W. B., . . . Goodacre, R. (2005). A laser desorption ionisation mass spectrometry approach for high throughput metabolomics. METABOLOMICS, 1(3), 243-250. doi:10.1007/s11306-005-0007-x

DOI
10.1007/s11306-005-0007-x
Journal article

Metabolic footprinting and systems biology: the medium is the message.

Kell, D. B., Brown, M., Davey, H. M., Dunn, W. B., Spasic, I., & Oliver, S. G. (2005). Metabolic footprinting and systems biology: the medium is the message.. Nature reviews. Microbiology, 3(7), 557-565. doi:10.1038/nrmicro1177

DOI
10.1038/nrmicro1177
Journal article

Novel biomarkers for pre-eclampsia detected using metabolomics and machine learning

Kenny, L. C., Dunn, W. B., Ellis, D. I., Myers, J., Baker, P. N., & Kell, D. B. (2005). Novel biomarkers for pre-eclampsia detected using metabolomics and machine learning. METABOLOMICS, 1(3), 227-234. doi:10.1007/s11306-005-0003-1

DOI
10.1007/s11306-005-0003-1
Journal article

Evaluation of automated electrospray-TOF mass spectrometryfor metabolic fingerprinting of the plant metabolome

Dunn, W. B., Overy, S., & Quick, W. P. (2005). Evaluation of automated electrospray-TOF mass spectrometryfor metabolic fingerprinting of the plant metabolome. METABOLOMICS, 1(2), 137-148. doi:10.1007/s11306-005-4433-6

DOI
10.1007/s11306-005-4433-6
Journal article

A metabolome pipeline: from concept to data to knowledge

Brown, M., Dunn, W. B., Ellis, D. I., Goodacre, R., Handl, J., Knowles, J. D., . . . Kell, D. B. (2005). A metabolome pipeline: from concept to data to knowledge. METABOLOMICS, 1(1), 39-51. doi:10.1007/s11306-005-1106-4

DOI
10.1007/s11306-005-1106-4
Journal article

Closed-loop, multiobjective optimization of analytical instrumentation: Gas chromatography/time-of-flight mass spectrometry of the metabolomes of human serum and of yeast fermentations

O'Hagan, S., Dunn, W. B., Brown, M., Knowles, J. D., & Kell, D. B. (2005). Closed-loop, multiobjective optimization of analytical instrumentation: Gas chromatography/time-of-flight mass spectrometry of the metabolomes of human serum and of yeast fermentations. ANALYTICAL CHEMISTRY, 77(1), 290-303. doi:10.1021/ac049146x

DOI
10.1021/ac049146x
Journal article

Measuring the metabolome: current analytical technologies

Dunn, W. B., Bailey, N. J. C., & Johnson, H. E. (2005). Measuring the metabolome: current analytical technologies. ANALYST, 130(5), 606-625. doi:10.1039/b418288j

DOI
10.1039/b418288j
Journal article

Metabolic footprinting and systems biology: The medium is the message

Kell, D. B., Brown, M., Davey, H. M., Dunn, W. B., Spasic, I., & Oliver, S. G. (2005). Metabolic footprinting and systems biology: The medium is the message. NATURE REVIEWS MICROBIOLOGY, 3(7), 557-565. doi:10.1038/nrmicro1177

DOI
10.1038/nrmicro1177
Journal article

Metabolomics: Current analytical platforms and methodologies

Dunn, W. B., & Ellis, D. I. (2005). Metabolomics: Current analytical platforms and methodologies. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 24(4), 285-294. doi:10.1016/j.trac.2004.11.021

DOI
10.1016/j.trac.2004.11.021
Journal article

2004

Metabolomics by numbers: acquiring and understanding global metabolite data

Goodacre, R., Vaidyanathan, S., Dunn, W. B., Harrigan, G. G., & Kell, D. B. (2004). Metabolomics by numbers: acquiring and understanding global metabolite data. TRENDS IN BIOTECHNOLOGY, 22(5), 245-252. doi:10.1016/j.tibtech.2004.03.007

DOI
10.1016/j.tibtech.2004.03.007
Journal article

1996

Novel techniques for the off-line analysis of liquid process streams by mass spectrometry

Townshend, A., Green, J. D., & Dunn, W. B. (1996). Novel techniques for the off-line analysis of liquid process streams by mass spectrometry. ANALYST, 121(10), 1435-1441. doi:10.1039/an9962101435

DOI
10.1039/an9962101435
Journal article

1995

THE POTENTIAL OF ONLINE HEADSPACE ANALYSIS OF LIQUID STREAMS USING DIRECT MASS-SPECTROMETRY DETECTION

TOWNSHEND, A., GREEN, J. D., & DUNN, W. B. (1995). THE POTENTIAL OF ONLINE HEADSPACE ANALYSIS OF LIQUID STREAMS USING DIRECT MASS-SPECTROMETRY DETECTION. ANALYTICAL PROCEEDINGS, 32(9), 361-363. doi:10.1039/ai9953200361

DOI
10.1039/ai9953200361
Journal article